BMRB Entry 15775

Name: Backbone chemical shift assignment for the transmembrane and C-terminal domains of amyloid precursor protein (APP C99)
Published: 2008-08-19

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PDB ID: 2lp1
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR15775
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: Backbone chemical shift assignment for the transmembrane and C-terminal domains of amyloid precursor protein (APP C99) PubMed: 18702528

Deposition date: 2008-05-15 Original release date: 2008-08-19

Authors: Sanders, Charles

Citation: Beel, Andrew; Mobley, Charles; Kim, Hak; Tian, Fang; Hadziselimovic, Arina; Jap, Bing; Prestegard, James; Sanders, Charles. "Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?" Biochemistry 47, 9428-9446 (2008).

Assembly members:
APP_C99, polymer, 122 residues, Formula weight is not available

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
APP_C99: MDAEFRHDSGYEVHHQKLVF FAEDVGSNKGAIIGLMVGGV VIATVIVITLVMLKKKQYTS IHHGVVEVDAAVTPEERHLS KMQQNGYENPTYKFFEQMQN QGRILQISITLAAALEHHHH HH

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	284
15N chemical shifts	99
1H chemical shifts	99

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HN(COCA)CB	sample_1	isotropic	sample_conditions_1

PDB	2LP1
DBJ	BAA22264 BAA84580 BAC34997 BAC36369 BAE01907
EMBL	CAA30050 CAA30488 CAA31830 CAA66230 CAA68374
GB	AAA35540 AAA36829 AAA37139 AAA51722 AAA51726
PIR	PQ0438
PRF	1303338A 1403400A 1507304A 1507304B 1507304C
REF	NP_000475 NP_001006601 NP_001013036 NP_001070264 NP_001127014
SP	P05067 P08592 P12023 P53601 P79307
TPG	DAA33655

Biological Magnetic Resonance Data Bank

BMRB Entry 15775

Title: Backbone chemical shift assignment for the transmembrane and C-terminal domains of amyloid precursor protein (APP C99) PubMed: 18702528

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