BMRB Entry 18412

Name: High Definition Solution Structure of PED/PEA-15 Death Effector Domain
Published: 2012-08-06

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PDB ID: 2ls7
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18412
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: High Definition Solution Structure of PED/PEA-15 Death Effector Domain PubMed: 22732408

Deposition date: 2012-04-20 Original release date: 2012-08-06

Authors: Twomey, Edward; Wei, Yufeng

Citation: Twomey, Edward; Wei, Yufeng. "High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions" Biochem. Biophys. Res. Commun. 424, 141-146 (2012).

Assembly members:
pea-15, polymer, 130 residues, 10450.842 Da.

Natural source: Common Name: Mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
pea-15: MAEYGTLLQDLTNNITLEDL EQLKSACKEDIPSEKSEEIT TGSAWFSFLESHNKLDKDNL SYIEHIFEISRRPDLLTMVV DYRTRVLKISEEDELDTKLT RIPSAKKYKDIIRQPSEEEI IKLAPPPKKA

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	472
15N chemical shifts	132
1H chemical shifts	858

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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1	MET	ALA	GLU	TYR	GLY	THR	LEU	LEU	GLN	ASP
2	LEU	THR	ASN	ASN	ILE	THR	LEU	GLU	ASP	LEU
3	GLU	GLN	LEU	LYS	SER	ALA	CYS	LYS	GLU	ASP
4	ILE	PRO	SER	GLU	LYS	SER	GLU	GLU	ILE	THR
5	THR	GLY	SER	ALA	TRP	PHE	SER	PHE	LEU	GLU
6	SER	HIS	ASN	LYS	LEU	ASP	LYS	ASP	ASN	LEU
7	SER	TYR	ILE	GLU	HIS	ILE	PHE	GLU	ILE	SER
8	ARG	ARG	PRO	ASP	LEU	LEU	THR	MET	VAL	VAL
9	ASP	TYR	ARG	THR	ARG	VAL	LEU	LYS	ILE	SER
10	GLU	GLU	ASP	GLU	LEU	ASP	THR	LYS	LEU	THR
11	ARG	ILE	PRO	SER	ALA	LYS	LYS	TYR	LYS	ASP
12	ILE	ILE	ARG	GLN	PRO	SER	GLU	GLU	GLU	ILE
13	ILE	LYS	LEU	ALA	PRO	PRO	PRO	LYS	LYS	ALA

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNHA	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1

PDB	1N3K 2LS7 4IZ5 4IZ7 4IZA
DBJ	BAC40734 BAE31752 BAE32041 BAE36504 BAE36662
EMBL	CAA60387 CAA60499 CAA74076 CAB51573 CAG46533
GB	AAC97496 AAD56775 AAH02426 AAH22554 AAH38282
REF	NP_001013249 NP_001068924 NP_001127112 NP_001185596 NP_001231780
SP	Q15121 Q5R529 Q5U318 Q62048 Q9Z297
TPG	DAA31971

Biological Magnetic Resonance Data Bank

BMRB Entry 18412

Title: High Definition Solution Structure of PED/PEA-15 Death Effector Domain PubMed: 22732408

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	MET	ALA	GLU	TYR	GLY	THR	LEU	LEU	GLN	ASP
2	LEU	THR	ASN	ASN	ILE	THR	LEU	GLU	ASP	LEU
3	GLU	GLN	LEU	LYS	SER	ALA	CYS	LYS	GLU	ASP
4	ILE	PRO	SER	GLU	LYS	SER	GLU	GLU	ILE	THR
5	THR	GLY	SER	ALA	TRP	PHE	SER	PHE	LEU	GLU
6	SER	HIS	ASN	LYS	LEU	ASP	LYS	ASP	ASN	LEU
7	SER	TYR	ILE	GLU	HIS	ILE	PHE	GLU	ILE	SER
8	ARG	ARG	PRO	ASP	LEU	LEU	THR	MET	VAL	VAL
9	ASP	TYR	ARG	THR	ARG	VAL	LEU	LYS	ILE	SER
10	GLU	GLU	ASP	GLU	LEU	ASP	THR	LYS	LEU	THR
11	ARG	ILE	PRO	SER	ALA	LYS	LYS	TYR	LYS	ASP
12	ILE	ILE	ARG	GLN	PRO	SER	GLU	GLU	GLU	ILE
13	ILE	LYS	LEU	ALA	PRO	PRO	PRO	LYS	LYS	ALA

1	MET	ALA	GLU	TYR	GLY	THR	LEU	LEU	GLN	ASP
2	LEU	THR	ASN	ASN	ILE	THR	LEU	GLU	ASP	LEU
3	GLU	GLN	LEU	LYS	SER	ALA	CYS	LYS	GLU	ASP
4	ILE	PRO	SER	GLU	LYS	SER	GLU	GLU	ILE	THR
5	THR	GLY	SER	ALA	TRP	PHE	SER	PHE	LEU	GLU
6	SER	HIS	ASN	LYS	LEU	ASP	LYS	ASP	ASN	LEU
7	SER	TYR	ILE	GLU	HIS	ILE	PHE	GLU	ILE	SER
8	ARG	ARG	PRO	ASP	LEU	LEU	THR	MET	VAL	VAL
9	ASP	TYR	ARG	THR	ARG	VAL	LEU	LYS	ILE	SER
10	GLU	GLU	ASP	GLU	LEU	ASP	THR	LYS	LEU	THR
11	ARG	ILE	PRO	SER	ALA	LYS	LYS	TYR	LYS	ASP
12	ILE	ILE	ARG	GLN	PRO	SER	GLU	GLU	GLU	ILE
13	ILE	LYS	LEU	ALA	PRO	PRO	PRO	LYS	LYS	ALA

1	MET	ALA	GLU	TYR	GLY	THR	LEU	LEU	GLN	ASP
2	LEU	THR	ASN	ASN	ILE	THR	LEU	GLU	ASP	LEU
3	GLU	GLN	LEU	LYS	SER	ALA	CYS	LYS	GLU	ASP
4	ILE	PRO	SER	GLU	LYS	SER	GLU	GLU	ILE	THR
5	THR	GLY	SER	ALA	TRP	PHE	SER	PHE	LEU	GLU
6	SER	HIS	ASN	LYS	LEU	ASP	LYS	ASP	ASN	LEU
7	SER	TYR	ILE	GLU	HIS	ILE	PHE	GLU	ILE	SER
8	ARG	ARG	PRO	ASP	LEU	LEU	THR	MET	VAL	VAL
9	ASP	TYR	ARG	THR	ARG	VAL	LEU	LYS	ILE	SER
10	GLU	GLU	ASP	GLU	LEU	ASP	THR	LYS	LEU	THR
11	ARG	ILE	PRO	SER	ALA	LYS	LYS	TYR	LYS	ASP
12	ILE	ILE	ARG	GLN	PRO	SER	GLU	GLU	GLU	ILE
13	ILE	LYS	LEU	ALA	PRO	PRO	PRO	LYS	LYS	ALA