BMRB Entry 20024
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR20024
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Title: NMR solution structure of mu-conotoxin TIIIA PubMed: 17142296
Deposition date: 2008-06-19 Original release date: 2008-07-15
Authors: Lewis, Richard; Schroeder, Christina
Citation: Lewis, Richard; Schroeder, Christina; Ekberg, Jenny; Nielsen, Katherine; Loughnan, Marion; Thomas, Linda; Adams, Denise; Drinkwater, Roger; Adams, David; Alewood, Paul. "Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels" Mol. Pharmacol. 71, 676-685 (2007).
Assembly members:
TIIIA, polymer, 22 residues, 2471.881 Da.
Natural source: Common Name: not available Taxonomy ID: not available Superkingdom: not available Kingdom: not available Genus/species: not available not available
Experimental source: Production method: recombinant technology
Entity Sequences (FASTA):
TIIIA: RHGCCKGXKGCSSRECRXQH
CC
- assigned_chemical_shifts
- conformer_family_coord_set
| Data type | Count |
| conformer coordinate sets | 1 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | TIIIA | 1 |
Entities:
Entity 1, TIIIA 22 residues - 2471.881 Da.
| 1 | ARG | HIS | GLY | CYS | CYS | LYS | GLY | HYP | LYS | GLY | ||||
| 2 | CYS | SER | SER | ARG | GLU | CYS | ARG | HYP | GLN | HIS | ||||
| 3 | CYS | CYS |
Samples:
sample_1: TIIIA 2 mM
sample_2: TIIIA 2 mM
sample_conditions_1: pH: 3; temperature: 286.5 K
sample_conditions_2: pH: 3; temperature: 286.5 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 2D DQF-COSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H TOCSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H NOESY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H TOCSY | sample_2 | isotropic | sample_conditions_2 |
| 2D 1H-1H NOESY | sample_2 | isotropic | sample_conditions_2 |
| 2D 1H-1H COSY | sample_2 | isotropic | sample_conditions_2 |
Software:
UXNMR, Bruker Biospin - collection