BMRB Entry 5047

Name: NMR structure of the LCCL Domain and its Implications for DFNA9 Deafness Disorder
Published: 2001-11-14

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5047

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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title: NMR structure of the LCCL Domain and its Implications for DFNA9 Deafness Disorder PubMed: 11574466

Deposition date: 2001-06-06 Original release date: 2001-11-14

Authors: Liepinsh, Edvards; Trexler, Maria; Kaikkonen, Andrei; Weigelt, Johan; Banyai, Laszlo; Patthy, Laszlo; Otting, Gottfried

Citation: Liepinsh, Edvards; Trexler, Maria; Kaikkonen, Andrei; Weigelt, Johan; Banyai, Laszlo; Patthy, Laszlo; Otting, Gottfried. "NMR structure of the LCCL Domain and its Implications for DFNA9 Deafness Disorder" EMBO J. 20, 5347-5353 (2001).

Assembly members:
Human coch-5h2 protein, polymer, 100 residues, 10467 Da.

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):
Human coch-5h2 protein: TAPIAITCFTRGLDIRKEKA DVLCPGGCPLEEFSVYGNIV YASVSSICGAAVHRGVISNS GGPVRVYSLPGRENYSSVDA NGIQSQMLSRWSASFTVTLE

Data sets:

assigned_chemical_shifts
- shift_set_1

Data type	Count
15N chemical shifts	108
1H chemical shifts	685

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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1	THR	ALA	PRO	ILE	ALA	ILE	THR	CYS	PHE	THR
2	ARG	GLY	LEU	ASP	ILE	ARG	LYS	GLU	LYS	ALA
3	ASP	VAL	LEU	CYS	PRO	GLY	GLY	CYS	PRO	LEU
4	GLU	GLU	PHE	SER	VAL	TYR	GLY	ASN	ILE	VAL
5	TYR	ALA	SER	VAL	SER	SER	ILE	CYS	GLY	ALA
6	ALA	VAL	HIS	ARG	GLY	VAL	ILE	SER	ASN	SER
7	GLY	GLY	PRO	VAL	ARG	VAL	TYR	SER	LEU	PRO
8	GLY	ARG	GLU	ASN	TYR	SER	SER	VAL	ASP	ALA
9	ASN	GLY	ILE	GLN	SER	GLN	MET	LEU	SER	ARG
10	TRP	SER	ALA	SER	PHE	THR	VAL	THR	LEU	GLU

Name	Sample	Sample state	Sample conditions
2D 1H-1H DQF-COSY	not available	not available	not available
2D 1H-1H HOHAHA	not available	not available	not available
2D 1H-1H NOESY	not available	not available	not available
2D 1H-1H ROESY	not available	not available	not available
2D 1H-15N HSQC	not available	not available	not available
3D 1H-1H-15N TOCSY	not available	not available	not available
3D 1H-1H-15N NOESY	not available	not available	not available

PDB	1JBI
DBJ	BAF85413
GenBank	AAC39545 AAH07230 AAQ89259 AAW82432 EAW65963
REF	NP_004077 XP_001114738 XP_001114756 XP_001114785 XP_001114797
SWISS-PROT	O43405

Biological Magnetic Resonance Data Bank

BMRB Entry 5047

Title: NMR structure of the LCCL Domain and its Implications for DFNA9 Deafness Disorder PubMed: 11574466

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	THR	ALA	PRO	ILE	ALA	ILE	THR	CYS	PHE	THR
2	ARG	GLY	LEU	ASP	ILE	ARG	LYS	GLU	LYS	ALA
3	ASP	VAL	LEU	CYS	PRO	GLY	GLY	CYS	PRO	LEU
4	GLU	GLU	PHE	SER	VAL	TYR	GLY	ASN	ILE	VAL
5	TYR	ALA	SER	VAL	SER	SER	ILE	CYS	GLY	ALA
6	ALA	VAL	HIS	ARG	GLY	VAL	ILE	SER	ASN	SER
7	GLY	GLY	PRO	VAL	ARG	VAL	TYR	SER	LEU	PRO
8	GLY	ARG	GLU	ASN	TYR	SER	SER	VAL	ASP	ALA
9	ASN	GLY	ILE	GLN	SER	GLN	MET	LEU	SER	ARG
10	TRP	SER	ALA	SER	PHE	THR	VAL	THR	LEU	GLU

1	THR	ALA	PRO	ILE	ALA	ILE	THR	CYS	PHE	THR
2	ARG	GLY	LEU	ASP	ILE	ARG	LYS	GLU	LYS	ALA
3	ASP	VAL	LEU	CYS	PRO	GLY	GLY	CYS	PRO	LEU
4	GLU	GLU	PHE	SER	VAL	TYR	GLY	ASN	ILE	VAL
5	TYR	ALA	SER	VAL	SER	SER	ILE	CYS	GLY	ALA
6	ALA	VAL	HIS	ARG	GLY	VAL	ILE	SER	ASN	SER
7	GLY	GLY	PRO	VAL	ARG	VAL	TYR	SER	LEU	PRO
8	GLY	ARG	GLU	ASN	TYR	SER	SER	VAL	ASP	ALA
9	ASN	GLY	ILE	GLN	SER	GLN	MET	LEU	SER	ARG
10	TRP	SER	ALA	SER	PHE	THR	VAL	THR	LEU	GLU

1	THR	ALA	PRO	ILE	ALA	ILE	THR	CYS	PHE	THR
2	ARG	GLY	LEU	ASP	ILE	ARG	LYS	GLU	LYS	ALA
3	ASP	VAL	LEU	CYS	PRO	GLY	GLY	CYS	PRO	LEU
4	GLU	GLU	PHE	SER	VAL	TYR	GLY	ASN	ILE	VAL
5	TYR	ALA	SER	VAL	SER	SER	ILE	CYS	GLY	ALA
6	ALA	VAL	HIS	ARG	GLY	VAL	ILE	SER	ASN	SER
7	GLY	GLY	PRO	VAL	ARG	VAL	TYR	SER	LEU	PRO
8	GLY	ARG	GLU	ASN	TYR	SER	SER	VAL	ASP	ALA
9	ASN	GLY	ILE	GLN	SER	GLN	MET	LEU	SER	ARG
10	TRP	SER	ALA	SER	PHE	THR	VAL	THR	LEU	GLU