BMRB Entry 18344
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR18344
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Title: Gal-GalNac-Interferon Alpha-2a PubMed: 23184955
Deposition date: 2012-03-21 Original release date: 2013-01-03
Authors: Ghasriani, Houman; Belcourt, Pascal; Sauve, Simon; Hodgson, Derek; Gingras, Genevieve; Brochu, Denis; Gilbert, Michel; Aubin, Yves
Citation: Ghasriani, Houman; Belcourt, Pascal; Sauve, Simon; Hodgson, Derek; Brochu, Denis; Gilbert, Michel; Aubin, Yves. "A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon 2a around the glycosylation site." J. Biol. Chem. 288, 247-254 (2013).
Assembly members:
ggIFN_alpha-2a, polymer, 165 residues, Formula weight is not available
D-Gal-beta(1-3)GalNAc-alpha-Thr, non-polymer, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
ggIFN_alpha-2a: CDLPQTHSLGSRRTLMLLAQ
MRKISLFSCLKDRHDFGFPQ
EEFGNQFQKAETIPVLHEMI
QQIFNLFSTKDSSAAWDETL
LDKFYTELYQQLNDLEACVI
QGVGVTETPLMKEDSILAVR
KYFQRITLYLKEKKYSPCAW
EVVRAEIMRSFSLSTNLQES
LRSKE
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 487 |
| 15N chemical shifts | 177 |
| 1H chemical shifts | 192 |