BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 26536

Title: Short hydrophobic peptides with cyclic constraints are po-tent GLP-1R agonists.   PubMed: 25839426

Deposition date: 2015-03-10 Original release date: 2015-04-13

Authors: Hoang, Huy

Citation: Hoang, Huy; Song, Kun; Hill, Timothy; Derksen, David; Edmonds, David; Kok, W. Mei; Limberakis, Chris; Liras, Spiros; Loria, Paula; Mascitti, Vincent; Mathiowetz, Alan; Mitchell, Justin; Piotrowski, David; Price, David; Stanton, Robert; Suen, Jacky; Withka, Jane; Griffith, David; Fairlie, David. "Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists"  J. Med. Chem. 58, 4080-4085 (2015).

Assembly members:
entity, polymer, 12 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
entity: HXEGTFTSDFFX

Data sets:
Data typeCount
1H chemical shifts20

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 12 residues - Formula weight is not available

1   HISAIBGLUGLYTHRPHETHRSERASPPHE
2   PHENH2

Samples:

sample_1: entity 1 mM

sample_conditions_1: ionic strength: 0.01 M; pH: 7; pressure: 1 atm; temperature: 298 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

X-PLOR_NIH, Schwieters, Kuszewski, Tjandra and Clore - structure solution

NMR spectrometers:

  • Bruker Avance 600 MHz