BMRB Entry 7110
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR7110
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Title: 1H, 13C, 15N CHEMICAL SHIFT FOR CBP BROMODOMIAN PubMed: 16426974
Deposition date: 2006-05-12 Original release date: 2006-06-28
Authors: ZHOU, MING-MING
Citation: Sachchidanand, .; Resnick-Silverman, Lois; Yan, Sherry; Mutjaba, Shiraz; Liu, Wen-jun; Zeng, Lei; Manfredi, James; Zhou, Ming-Ming. "Target structure-based discovery of small molecules that block human p53 and CREB binding protein association" Chem. Biol. 13, 81-90 (2006).
Assembly members:
CBP, polymer, 121 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: Purified from the natural source
Entity Sequences (FASTA):
CBP: GSHMRKKIFKPEELRQALMP
TLEALYRQDPESLPFRQPVD
PQLLGIPDYFDIVKNPMDLS
TIKRKLDTGQYQEPWQYVDD
VWLMFNNAWLYNRKTSRVYK
FCSKLAEVFEQEIDPVMQSL
G
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 400 |
| 15N chemical shifts | 103 |
| 1H chemical shifts | 544 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | CBP BROMODOMAIN | 1 |
Entities:
Entity 1, CBP BROMODOMAIN 121 residues - Formula weight is not available
| 1 | GLY | SER | HIS | MET | ARG | LYS | LYS | ILE | PHE | LYS | ||||
| 2 | PRO | GLU | GLU | LEU | ARG | GLN | ALA | LEU | MET | PRO | ||||
| 3 | THR | LEU | GLU | ALA | LEU | TYR | ARG | GLN | ASP | PRO | ||||
| 4 | GLU | SER | LEU | PRO | PHE | ARG | GLN | PRO | VAL | ASP | ||||
| 5 | PRO | GLN | LEU | LEU | GLY | ILE | PRO | ASP | TYR | PHE | ||||
| 6 | ASP | ILE | VAL | LYS | ASN | PRO | MET | ASP | LEU | SER | ||||
| 7 | THR | ILE | LYS | ARG | LYS | LEU | ASP | THR | GLY | GLN | ||||
| 8 | TYR | GLN | GLU | PRO | TRP | GLN | TYR | VAL | ASP | ASP | ||||
| 9 | VAL | TRP | LEU | MET | PHE | ASN | ASN | ALA | TRP | LEU | ||||
| 10 | TYR | ASN | ARG | LYS | THR | SER | ARG | VAL | TYR | LYS | ||||
| 11 | PHE | CYS | SER | LYS | LEU | ALA | GLU | VAL | PHE | GLU | ||||
| 12 | GLN | GLU | ILE | ASP | PRO | VAL | MET | GLN | SER | LEU | ||||
| 13 | GLY |
Samples:
sample_1: CBP
conditions_1: pH: 6.5
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| HNCACB | sample_1 | not available | conditions_1 |
| HN(CO)CACB | sample_1 | not available | conditions_1 |
| HCCH-TOCSY | sample_1 | 100% D2O | conditions_1 |
| (H)C(CO)NH-TOCSY | sample_1 | not available | conditions_1 |
| 15N-ed-NOESY | sample_1 | 10% D2O | conditions_1 |
| 13C-ed_NOESY | sample_1 | 100% D2O | conditions_1 |
| 13C15N-filt-NOESY | sample_1 | 100% D2O | conditions_1 |
Software:
No software information available
NMR spectrometers:
- Bruker avance 800 MHz
- Bruker DRX 500 MHz
Related Database Links:
| BMRB | 17392 17393 6960 |
| PDB | |
| DBJ | BAE06125 BAG65526 BAI45616 |
| GB | AAB28651 AAC51331 AAC51770 AAH72594 AAI72737 |
| PRF | 1923401A |
| REF | NP_001020603 NP_001073315 NP_001157494 NP_001247644 NP_004371 |
| SP | P45481 Q6JHU9 Q92793 |
| TPG | DAA15549 |
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