REMARK SPARTA+ Protein Chemical Shift Prediction Table REMARK REMARK All chemical shifts are reported in ppm: REMARK REMARK SS_SHIFT is the predicted secondary chemical shift. REMARK SHIFT is the predicted chemical shift. REMARK RC_SHIFT is the random coil chemical shift. REMARK HM_SHIFT is the ring current shift; a correction REMARK of 0.6 times this value is applied. REMARK EF_SHIFT is the adjustment for electric field effect, REMARK applied to proton shifts only. REMARK SIGMA is the estimated prediction error. REMARK REMARK Reference: REMARK Y. Shen and A. Bax: SPARTA+: a modest improvement in empirical NMR REMARK chemical shift prediction by means of an artificial neural network. REMARK J. Biomol. NMR 48, 13-22 (2010). DATA SOURCE 2kqd_1_A DATA FIRST_RESID 363 DATA SEQUENCE GPLGSGSEGN KVKRTSCMYG ANCYRKNPVH FQHFSHPGDS DYGGVQIVGQ DATA SEQUENCE DETDD VARS RESID RESNAME ATOMNAME SS_SHIFT SHIFT RC_SHIFT HM_SHIFT EF_SHIFT SIGMA FORMAT %4d %4s %4s %9.3f %9.3f %9.3f %9.3f %9.3f %9.3f 363 G HA2 0.000 nan 3.960 nan 0.000 0.244 363 G HA3 0.000 3.955 3.960 -0.009 0.000 0.244 363 G C 0.000 174.895 174.900 -0.009 0.000 0.946 363 G CA 0.000 45.095 45.100 -0.009 0.000 0.502 364 P HA 0.286 4.702 4.420 -0.006 0.000 0.275 364 P C -0.881 176.411 177.300 -0.013 0.000 1.228 364 P CA -0.400 62.694 63.100 -0.009 0.000 0.786 364 P CB 1.260 32.956 31.700 -0.007 0.000 0.927 365 L N -0.334 120.881 121.223 -0.014 0.000 2.332 365 L HA 0.153 4.478 4.340 -0.026 0.000 0.242 365 L C -0.421 176.435 176.870 -0.022 0.000 1.127 365 L CA -0.008 54.819 54.840 -0.022 0.000 0.948 365 L CB 1.575 43.621 42.059 -0.022 0.000 1.553 365 L HN -0.159 8.066 8.230 -0.009 0.000 0.419 366 G N 0.341 109.120 108.800 -0.035 0.000 2.798 366 G HA2 -0.134 3.801 3.960 -0.042 0.000 0.167 366 G HA3 -0.134 3.814 3.960 -0.020 0.000 0.167 366 G C -0.862 174.006 174.900 -0.054 0.000 1.082 366 G CA 0.200 45.278 45.100 -0.037 0.000 0.905 366 G HN 0.629 8.892 8.290 -0.045 0.000 0.514 367 S N -0.369 115.282 115.700 -0.080 0.000 2.472 367 S HA 0.069 4.491 4.470 -0.081 0.000 0.191 367 S C 0.107 174.625 174.600 -0.137 0.000 1.244 367 S CA -0.568 57.578 58.200 -0.090 0.000 1.227 367 S CB 0.899 64.061 63.200 -0.064 0.000 1.381 367 S HN -0.123 8.135 8.310 -0.087 0.000 0.394 368 G N 1.501 110.174 108.800 -0.211 0.000 2.671 368 G HA2 0.216 4.042 3.960 -0.224 0.000 0.318 368 G HA3 0.216 3.976 3.960 -0.333 0.000 0.318 368 G C -1.697 172.941 174.900 -0.436 0.000 1.250 368 G CA 0.031 44.954 45.100 -0.294 0.000 1.028 368 G HN -0.216 7.944 8.290 -0.217 0.000 0.501 369 S N 3.066 118.592 115.700 -0.289 0.000 2.775 369 S HA 0.159 4.380 4.470 -0.416 0.000 0.277 369 S C -1.096 173.448 174.600 -0.093 0.000 1.156 369 S CA 0.056 58.115 58.200 -0.236 0.000 1.081 369 S CB 1.252 64.386 63.200 -0.111 0.000 1.054 369 S HN 0.195 8.385 8.310 -0.199 0.000 0.482 370 E N 8.775 128.947 120.200 -0.045 0.000 2.114 370 E HA 0.243 4.584 4.350 -0.015 0.000 0.266 370 E C -0.762 175.873 176.600 0.060 0.000 0.896 370 E CA -1.111 55.287 56.400 -0.002 0.000 0.750 370 E CB 1.297 30.983 29.700 -0.024 0.000 1.121 370 E HN -0.372 7.965 8.360 -0.038 0.000 0.413 371 G N 3.405 112.236 108.800 0.052 0.000 2.616 371 G HA2 -0.228 3.786 3.960 0.091 0.000 0.215 371 G HA3 -0.228 3.763 3.960 0.052 0.000 0.215 371 G C -0.594 174.346 174.900 0.065 0.000 1.284 371 G CA 1.357 46.498 45.100 0.067 0.000 0.823 371 G HN 0.336 8.645 8.290 0.032 0.000 0.569 372 N N -1.888 116.839 118.700 0.045 0.000 2.527 372 N HA 0.031 4.803 4.740 0.054 0.000 0.279 372 N C -1.556 173.972 175.510 0.029 0.000 1.571 372 N CA 0.335 53.410 53.050 0.042 0.000 0.858 372 N CB 0.713 39.221 38.487 0.034 0.000 1.422 372 N HN -0.136 8.265 8.380 0.035 0.000 0.491 373 K N 0.205 120.619 120.400 0.023 0.000 3.360 373 K HA 0.194 4.524 4.320 0.016 0.000 0.179 373 K C -2.193 174.411 176.600 0.006 0.000 1.034 373 K CA 0.335 56.631 56.287 0.014 0.000 0.938 373 K CB 0.370 32.876 32.500 0.010 0.000 0.696 373 K HN -0.249 8.016 8.250 0.024 0.000 0.437 374 V N -1.349 118.569 119.914 0.006 0.000 3.188 374 V HA 0.175 4.288 4.120 -0.011 0.000 0.305 374 V C -1.571 174.518 176.094 -0.009 0.000 1.232 374 V CA -1.431 60.864 62.300 -0.009 0.000 1.043 374 V CB 4.458 36.269 31.823 -0.020 0.000 1.068 374 V HN -0.525 7.675 8.190 0.016 0.000 0.439 375 K N 3.189 123.574 120.400 -0.024 0.000 2.167 375 K HA -0.023 4.291 4.320 -0.010 0.000 0.275 375 K C -0.539 176.032 176.600 -0.049 0.000 1.103 375 K CA -0.282 55.987 56.287 -0.029 0.000 0.963 375 K CB -1.035 31.441 32.500 -0.040 0.000 1.243 375 K HN 0.198 8.430 8.250 -0.030 0.000 0.407 376 R N 3.181 123.663 120.500 -0.031 0.000 2.734 376 R HA -0.039 4.479 4.340 -0.103 -0.240 0.266 376 R C 0.960 177.200 176.300 -0.098 0.000 1.044 376 R CA 0.622 56.683 56.100 -0.065 0.000 1.128 376 R CB 0.876 31.174 30.300 -0.003 0.000 1.010 376 R HN -0.383 7.889 8.270 0.002 0.000 0.461 377 T N 1.623 116.078 114.554 -0.166 0.000 2.884 377 T HA 0.006 4.272 4.350 -0.139 0.000 0.298 377 T C -0.026 174.618 174.700 -0.094 0.000 0.998 377 T CA -0.479 61.529 62.100 -0.154 0.000 1.124 377 T CB 0.750 69.490 68.868 -0.213 0.000 0.931 377 T HN 0.304 8.403 8.240 -0.234 0.000 0.531 378 S N 6.754 122.396 115.700 -0.096 0.000 2.559 378 S HA -0.260 4.363 4.470 0.076 -0.108 0.282 378 S C -0.089 174.559 174.600 0.081 0.000 1.336 378 S CA 1.508 59.702 58.200 -0.010 0.000 1.037 378 S CB 0.262 63.382 63.200 -0.132 0.000 0.853 378 S HN 0.275 8.497 8.310 -0.148 0.000 0.523 379 C N 4.537 123.879 119.300 0.069 0.000 2.595 379 C HA 0.106 4.777 4.460 0.351 0.000 0.384 379 C C 1.934 176.961 174.990 0.063 0.000 1.289 379 C CA 0.147 59.229 59.018 0.108 0.000 2.372 379 C CB 1.029 28.752 27.740 -0.029 0.000 2.593 379 C HN -0.122 8.136 8.230 0.047 0.000 0.639 380 M N 4.506 124.089 119.600 -0.028 0.000 2.192 380 M HA -0.230 4.073 4.480 -0.295 0.000 0.259 380 M C -0.280 175.640 176.300 -0.633 0.000 1.071 380 M CA 2.933 58.017 55.300 -0.359 0.000 1.082 380 M CB -0.005 32.343 32.600 -0.421 0.000 1.373 380 M HN 0.685 8.954 8.290 -0.036 0.000 0.408 381 Y N -5.604 114.734 120.300 0.064 0.000 2.734 381 Y HA 0.284 4.889 4.550 0.092 0.000 0.251 381 Y C 0.656 176.629 175.900 0.121 0.000 1.049 381 Y CA -1.568 56.584 58.100 0.086 0.000 1.103 381 Y CB -0.972 37.532 38.460 0.073 0.000 1.201 381 Y HN -0.746 7.640 8.280 0.227 0.030 0.618 382 G N 2.010 110.972 108.800 0.269 0.000 2.606 382 G HA2 -0.475 3.794 3.960 0.514 0.000 0.221 382 G HA3 -0.475 3.647 3.960 0.269 0.000 0.221 382 G C 0.905 175.923 174.900 0.197 0.000 1.152 382 G CA 2.714 47.998 45.100 0.307 0.000 0.765 382 G HN -0.210 8.093 8.290 0.204 0.110 0.595 383 A N 0.367 123.277 122.820 0.149 0.000 2.024 383 A HA -0.119 4.214 4.320 0.022 0.000 0.220 383 A C 0.629 178.277 177.584 0.105 0.000 1.164 383 A CA 2.227 54.318 52.037 0.089 0.000 0.643 383 A CB -0.314 18.748 19.000 0.104 0.000 0.806 383 A HN 0.473 8.728 8.150 0.185 0.006 0.451 384 N N -6.293 112.500 118.700 0.155 0.000 2.387 384 N HA 0.129 4.925 4.740 0.094 0.000 0.259 384 N C -1.938 173.649 175.510 0.128 0.000 1.369 384 N CA -0.386 52.741 53.050 0.129 0.000 0.867 384 N CB 1.771 40.339 38.487 0.134 0.000 1.341 384 N HN 0.318 8.677 8.380 0.211 0.148 0.495 385 C N 3.239 122.615 119.300 0.126 0.000 2.757 385 C HA -0.130 4.317 4.460 -0.021 0.000 0.394 385 C C 1.377 176.271 174.990 -0.160 0.000 1.311 385 C CA 1.747 60.760 59.018 -0.009 0.000 1.323 385 C CB -2.774 25.006 27.740 0.067 0.000 2.159 385 C HN -0.353 7.872 8.230 0.171 0.108 0.611 386 Y N 5.115 125.347 120.300 -0.114 0.000 2.224 386 Y HA -0.236 4.262 4.550 -0.087 0.000 0.289 386 Y C -0.868 174.936 175.900 -0.159 0.000 1.146 386 Y CA 1.336 59.362 58.100 -0.123 0.000 1.182 386 Y CB -0.815 37.562 38.460 -0.138 0.000 0.983 386 Y HN -0.105 8.188 8.280 0.022 0.000 0.524 387 R N 0.181 119.947 120.500 -1.223 0.000 2.637 387 R HA -0.009 4.078 4.340 -0.421 0.000 0.269 387 R C -1.388 174.544 176.300 -0.615 0.000 1.089 387 R CA -0.179 55.433 56.100 -0.813 0.000 1.177 387 R CB 1.131 30.801 30.300 -1.049 0.000 1.091 387 R HN -0.494 6.587 8.270 -1.961 0.012 0.540 388 K N -0.363 119.757 120.400 -0.466 0.000 2.635 388 K HA 0.169 4.049 4.320 -0.734 0.000 0.266 388 K C -2.030 174.429 176.600 -0.235 0.000 1.033 388 K CA -0.534 55.504 56.287 -0.414 0.000 0.919 388 K CB 0.262 32.691 32.500 -0.117 0.000 1.289 388 K HN 0.048 8.082 8.250 -0.360 0.000 0.463 389 N N 4.149 122.693 118.700 -0.261 0.000 2.457 389 N HA 0.539 5.265 4.740 -0.025 0.000 0.290 389 N C -0.780 174.811 175.510 0.135 0.000 1.232 389 N CA -3.219 49.803 53.050 -0.045 0.000 0.852 389 N CB 1.302 39.748 38.487 -0.069 0.000 1.313 389 N HN -0.113 7.980 8.380 -0.479 0.000 0.522 390 P HA 0.030 4.595 4.420 0.241 0.000 0.222 390 P C -0.121 177.281 177.300 0.170 0.000 1.153 390 P CA 2.069 65.272 63.100 0.171 0.000 0.798 390 P CB 0.456 32.210 31.700 0.090 0.000 0.796 391 V N -3.835 116.132 119.914 0.089 0.000 3.431 391 V HA 0.104 4.541 4.120 0.058 -0.283 0.253 391 V C 1.319 177.401 176.094 -0.019 0.000 1.184 391 V CA 0.859 63.166 62.300 0.011 0.000 1.104 391 V CB 0.179 31.945 31.823 -0.094 0.000 0.799 391 V HN -0.472 7.731 8.190 0.059 0.022 0.462 392 H N 1.786 120.809 119.070 -0.078 0.000 2.387 392 H HA -0.297 4.285 4.556 0.043 0.000 0.299 392 H C 1.313 176.722 175.328 0.136 0.000 1.090 392 H CA 3.976 60.005 56.048 -0.032 0.000 1.332 392 H CB -0.118 29.509 29.762 -0.225 0.000 1.386 392 H HN 0.057 8.407 8.280 0.116 0.000 0.516 393 F N -3.469 116.649 119.950 0.280 0.000 2.202 393 F HA -0.141 4.672 4.527 0.476 0.000 0.301 393 F C 1.605 177.530 175.800 0.209 0.000 1.082 393 F CA 3.628 61.800 58.000 0.287 0.000 1.313 393 F CB -0.328 38.776 39.000 0.173 0.000 1.024 393 F HN -0.648 7.807 8.300 0.258 0.000 0.495 394 Q N -3.538 116.460 119.800 0.329 0.000 2.187 394 Q HA -0.220 4.299 4.340 0.223 -0.045 0.199 394 Q C 2.193 178.346 176.000 0.255 0.000 0.957 394 Q CA 2.637 58.595 55.803 0.258 0.000 0.857 394 Q CB -0.023 28.857 28.738 0.236 0.000 0.929 394 Q HN -0.669 7.655 8.270 0.296 0.124 0.453 395 H N -1.615 117.452 119.070 -0.004 0.000 2.448 395 H HA -0.129 4.253 4.556 -0.290 0.000 0.292 395 H C 0.056 174.993 175.328 -0.652 0.000 1.035 395 H CA 1.516 57.391 56.048 -0.289 0.000 1.349 395 H CB 1.397 31.059 29.762 -0.166 0.000 1.425 395 H HN -0.792 7.566 8.280 0.292 0.097 0.539 396 F N -3.693 116.179 119.950 -0.130 0.000 2.532 396 F HA 0.470 5.018 4.527 -0.181 -0.129 0.321 396 F C -1.262 174.388 175.800 -0.251 0.000 1.089 396 F CA -1.382 56.465 58.000 -0.254 0.000 0.926 396 F CB 2.991 41.711 39.000 -0.467 0.000 1.168 396 F HN -0.226 8.213 8.300 0.232 0.000 0.459 397 S N -0.408 115.242 115.700 -0.085 0.000 2.707 397 S HA 0.144 4.737 4.470 0.205 0.000 0.276 397 S C -1.610 172.854 174.600 -0.227 0.000 1.179 397 S CA -0.809 57.408 58.200 0.030 0.000 0.992 397 S CB 1.431 64.710 63.200 0.131 0.000 1.030 397 S HN 0.854 8.988 8.310 -0.064 0.138 0.554 398 H N -1.661 117.630 119.070 0.369 0.000 2.961 398 H HA 0.313 4.961 4.556 0.153 0.000 0.371 398 H C -2.253 172.828 175.328 -0.412 0.000 1.190 398 H CA -2.434 53.683 56.048 0.114 0.000 1.138 398 H CB 2.762 32.634 29.762 0.184 0.000 1.816 398 H HN -0.085 8.439 8.280 0.407 0.000 0.551 399 P HA -0.218 3.101 4.420 -1.836 0.000 0.268 399 P C 0.339 177.443 177.300 -0.327 0.000 1.204 399 P CA 1.294 63.681 63.100 -1.188 0.000 0.768 399 P CB 0.475 31.646 31.700 -0.882 0.000 0.842 400 G N 2.356 111.065 108.800 -0.153 0.000 2.179 400 G HA2 -0.210 3.740 3.960 -0.017 0.000 0.220 400 G HA3 -0.210 3.726 3.960 -0.040 0.000 0.220 400 G C -1.024 173.889 174.900 0.021 0.000 0.990 400 G CA -0.177 44.903 45.100 -0.035 0.000 0.646 400 G HN 0.399 8.615 8.290 -0.123 0.000 0.517 401 D N -0.490 119.953 120.400 0.071 0.000 2.392 401 D HA 0.245 4.923 4.640 0.063 0.000 0.246 401 D C 0.228 176.599 176.300 0.119 0.000 1.013 401 D CA -1.205 52.855 54.000 0.100 0.000 0.993 401 D CB 2.426 43.317 40.800 0.153 0.000 1.219 401 D HN -0.625 7.744 8.370 0.077 0.047 0.538 402 S N -0.801 114.953 115.700 0.089 0.000 2.428 402 S HA -0.150 4.366 4.470 0.076 0.000 0.230 402 S C -0.089 174.566 174.600 0.091 0.000 1.014 402 S CA 2.058 60.306 58.200 0.078 0.000 0.957 402 S CB 0.110 63.340 63.200 0.051 0.000 0.784 402 S HN 0.526 8.880 8.310 0.072 0.000 0.499 403 D N -1.890 118.575 120.400 0.108 0.000 2.340 403 D HA 0.135 4.807 4.640 0.054 0.000 0.217 403 D C -0.078 176.294 176.300 0.121 0.000 1.081 403 D CA -0.253 53.800 54.000 0.087 0.000 0.842 403 D CB 0.152 40.995 40.800 0.071 0.000 0.934 403 D HN -0.023 8.396 8.370 0.118 0.022 0.511 404 Y N 3.362 123.685 120.300 0.037 0.000 2.702 404 Y HA -0.364 4.201 4.550 0.024 0.000 0.336 404 Y C -0.396 175.511 175.900 0.013 0.000 1.235 404 Y CA 1.441 59.560 58.100 0.032 0.000 1.492 404 Y CB 0.306 38.800 38.460 0.055 0.000 1.308 404 Y HN -0.868 7.532 8.280 0.288 0.052 0.589 405 G N 5.242 113.586 108.800 -0.759 0.000 5.414 405 G HA2 0.098 3.794 3.960 -0.440 0.000 0.202 405 G HA3 0.098 3.873 3.960 -0.307 0.000 0.202 405 G C -1.718 172.811 174.900 -0.618 0.000 0.727 405 G CA 0.044 44.821 45.100 -0.538 0.000 0.670 405 G HN 0.038 7.735 8.290 -0.989 0.000 0.442 406 G N -1.241 106.913 108.800 -1.077 0.000 2.570 406 G HA2 0.023 3.795 3.960 -0.314 0.000 0.209 406 G HA3 0.023 3.738 3.960 -0.408 0.000 0.209 406 G C -0.448 174.297 174.900 -0.257 0.000 1.168 406 G CA -0.279 44.520 45.100 -0.501 0.000 0.831 406 G HN -0.340 6.589 8.290 -2.269 0.000 0.564 407 V N 0.875 120.682 119.914 -0.179 0.000 5.889 407 V HA -0.393 3.811 4.120 0.140 0.000 0.209 407 V C -1.064 175.045 176.094 0.026 0.000 0.681 407 V CA 1.223 63.535 62.300 0.019 0.000 0.547 407 V CB -1.861 29.938 31.823 -0.040 0.000 0.309 407 V HN -0.161 7.828 8.190 -0.334 0.000 0.471 408 Q N 2.109 121.950 119.800 0.069 0.000 2.834 408 Q HA 0.162 4.512 4.340 0.018 0.000 0.271 408 Q C -0.610 175.422 176.000 0.053 0.000 1.196 408 Q CA -0.933 54.896 55.803 0.043 0.000 1.063 408 Q CB -0.852 27.911 28.738 0.042 0.000 1.265 408 Q HN 0.211 8.560 8.270 0.132 0.000 0.526 409 I N -0.560 120.037 120.570 0.046 0.000 7.474 409 I HA -0.401 3.792 4.170 0.039 0.000 0.126 409 I C -1.050 175.101 176.117 0.057 0.000 1.805 409 I CA 0.426 61.752 61.300 0.044 0.000 2.128 409 I CB -1.368 36.652 38.000 0.034 0.000 3.592 409 I HN 0.135 8.368 8.210 0.038 0.000 0.196 410 V N 4.188 124.143 119.914 0.068 0.000 2.220 410 V HA 0.069 4.229 4.120 0.067 0.000 0.265 410 V C -0.029 176.099 176.094 0.055 0.000 1.078 410 V CA -0.317 62.025 62.300 0.071 0.000 0.872 410 V CB -0.898 30.983 31.823 0.097 0.000 1.121 410 V HN 0.007 8.240 8.190 0.070 0.000 0.460 411 G N 5.937 114.763 108.800 0.044 0.000 2.401 411 G HA2 -0.226 3.753 3.960 0.032 0.000 0.283 411 G HA3 -0.226 3.755 3.960 0.035 0.000 0.283 411 G C 0.518 175.438 174.900 0.034 0.000 1.117 411 G CA -0.301 44.821 45.100 0.036 0.000 1.051 411 G HN 0.379 8.695 8.290 0.043 0.000 0.510 412 Q N -0.089 119.730 119.800 0.031 0.000 1.967 412 Q HA -0.234 4.124 4.340 0.030 0.000 0.210 412 Q C -0.230 175.784 176.000 0.023 0.000 1.005 412 Q CA 1.770 57.589 55.803 0.027 0.000 0.862 412 Q CB 0.226 28.978 28.738 0.023 0.000 0.939 412 Q HN 0.239 8.527 8.270 0.031 0.000 0.417 413 D N -3.860 116.552 120.400 0.020 0.000 3.120 413 D HA 0.164 4.815 4.640 0.018 0.000 0.331 413 D C -1.192 175.117 176.300 0.016 0.000 1.595 413 D CA 0.331 54.341 54.000 0.018 0.000 0.771 413 D CB 0.213 41.022 40.800 0.015 0.000 1.274 413 D HN -0.145 8.237 8.370 0.020 0.000 0.503 414 E N 0.357 120.567 120.200 0.017 0.000 2.939 414 E HA 0.152 4.510 4.350 0.014 0.000 0.215 414 E C -0.899 175.710 176.600 0.015 0.000 1.025 414 E CA -0.051 56.358 56.400 0.015 0.000 1.259 414 E CB 0.318 30.028 29.700 0.016 0.000 1.228 414 E HN -0.207 8.165 8.360 0.019 0.000 0.443 415 T N -2.661 111.902 114.554 0.015 0.000 3.427 415 T HA 0.228 4.586 4.350 0.014 0.000 0.306 415 T C -0.218 174.489 174.700 0.012 0.000 1.733 415 T CA 0.086 62.194 62.100 0.014 0.000 1.599 415 T CB -0.044 68.833 68.868 0.016 0.000 0.964 415 T HN -0.303 7.883 8.240 0.015 0.063 0.701 416 D N 1.327 121.734 120.400 0.011 0.000 2.892 416 D HA 0.217 4.863 4.640 0.010 0.000 0.291 416 D C -0.982 175.323 176.300 0.008 0.000 1.341 416 D CA 0.089 54.095 54.000 0.009 0.000 0.844 416 D CB 0.604 41.410 40.800 0.009 0.000 1.093 416 D HN 0.074 8.451 8.370 0.011 0.000 0.480 417 D N 0.000 120.405 120.400 0.009 0.000 6.856 417 D HA 0.000 4.644 4.640 0.007 0.000 0.175 417 D CA 0.000 54.005 54.000 0.007 0.000 0.868 417 D CB 0.000 40.805 40.800 0.008 0.000 0.688 417 D HN 0.000 8.317 8.370 0.009 0.059 0.683