==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER PROTEIN BINDING/TRANSFERASE 05-JUL-05 2A78 . COMPND 2 MOLECULE: RAS-RELATED PROTEIN RAL-A; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR A.PAUTSCH,M.VOGELSGESANG,J.TRANKLE,C.HERRMANN,K.AKTORIES . 377 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 17479.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 286 75.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 33 8.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 49 13.0 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 37 9.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 43 11.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 109 28.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 0 0 3 1 1 1 0 0 1 0 1 0 0 0 0 1 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 0 0 2 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 1 0 2 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 13 A A 0 0 90 0, 0.0 50,-3.2 0, 0.0 2,-0.5 0.000 360.0 360.0 360.0 142.0 18.9 -1.9 -10.8 2 14 A L E -a 51 0A 52 48,-0.2 2,-0.7 40,-0.0 50,-0.2 -0.976 360.0-160.0-124.4 115.4 18.5 0.8 -8.1 3 15 A H E -a 52 0A 2 48,-2.7 50,-2.8 -2,-0.5 2,-0.8 -0.866 10.4-148.8-101.4 114.2 16.3 -0.2 -5.1 4 16 A K E -a 53 0A 69 -2,-0.7 71,-2.4 48,-0.2 72,-1.9 -0.720 17.8-173.9 -92.6 107.4 15.0 2.9 -3.3 5 17 A V E -ab 54 76A 0 48,-3.9 50,-2.6 -2,-0.8 2,-0.5 -0.822 9.4-158.9-102.1 138.8 14.5 2.2 0.4 6 18 A I E -ab 55 77A 6 70,-2.7 72,-2.3 -2,-0.4 2,-0.5 -0.971 10.7-143.3-115.6 129.6 13.0 4.5 3.0 7 19 A M E +ab 56 78A 0 48,-2.8 50,-0.7 -2,-0.5 2,-0.3 -0.791 28.0 173.6 -84.8 125.9 13.6 4.2 6.7 8 20 A V E + b 0 79A 0 70,-2.7 72,-3.0 -2,-0.5 2,-0.2 -0.911 18.6 99.2-129.3 163.8 10.5 5.1 8.7 9 21 A G - 0 0 0 -2,-0.3 72,-0.2 70,-0.2 3,-0.1 -0.549 69.0 -56.4 136.0 154.1 9.7 4.9 12.4 10 22 A S S > S- 0 0 1 70,-0.4 3,-1.4 78,-0.3 5,-0.3 -0.053 70.0 -79.4 -56.3 157.7 9.6 7.0 15.5 11 23 A G T 3 S+ 0 0 8 209,-2.5 -1,-0.2 1,-0.2 211,-0.1 -0.333 115.6 21.6 -54.8 136.1 12.6 9.0 16.7 12 24 A G T 3 S+ 0 0 50 -3,-0.1 -1,-0.2 21,-0.1 -2,-0.1 0.498 83.1 114.8 88.0 5.0 15.1 6.8 18.6 13 25 A V S < S- 0 0 2 -3,-1.4 70,-0.1 67,-0.1 68,-0.1 0.744 92.8 -96.8 -82.3 -21.3 14.1 3.4 17.2 14 26 A G S > S+ 0 0 13 -4,-0.2 4,-2.7 66,-0.1 5,-0.3 0.609 75.5 139.8 117.3 23.4 17.4 2.8 15.5 15 27 A K H > S+ 0 0 13 -5,-0.3 4,-2.1 1,-0.2 5,-0.1 0.940 81.6 41.6 -58.2 -48.5 16.8 3.9 11.8 16 28 A S H > S+ 0 0 21 2,-0.2 4,-2.8 1,-0.2 5,-0.2 0.930 115.2 49.4 -65.0 -48.1 20.2 5.6 11.6 17 29 A A H > S+ 0 0 13 1,-0.2 4,-2.6 2,-0.2 11,-0.2 0.920 112.7 48.1 -59.0 -44.6 22.1 2.9 13.5 18 30 A L H X S+ 0 0 0 -4,-2.7 4,-2.5 2,-0.2 -1,-0.2 0.904 112.9 48.7 -61.5 -42.8 20.5 0.2 11.3 19 31 A T H X S+ 0 0 0 -4,-2.1 4,-2.8 -5,-0.3 -2,-0.2 0.922 114.8 43.9 -64.1 -44.0 21.4 2.2 8.1 20 32 A L H X S+ 0 0 10 -4,-2.8 4,-2.8 2,-0.2 6,-0.5 0.830 111.9 53.4 -74.7 -32.3 25.0 2.8 9.2 21 33 A Q H X S+ 0 0 8 -4,-2.6 4,-1.5 -5,-0.2 -2,-0.2 0.937 114.7 42.0 -62.9 -47.3 25.4 -0.8 10.3 22 34 A F H < S+ 0 0 1 -4,-2.5 -2,-0.2 -5,-0.2 -1,-0.2 0.938 121.4 41.3 -63.0 -46.9 24.2 -2.0 6.9 23 35 A M H < S+ 0 0 12 -4,-2.8 -2,-0.2 -5,-0.2 -3,-0.2 0.915 134.9 11.2 -69.6 -47.0 26.2 0.6 5.0 24 36 A Y H < S- 0 0 123 -4,-2.8 -3,-0.2 2,-0.2 -1,-0.2 0.255 92.5-118.4-126.1 8.6 29.5 0.6 6.9 25 37 A D S < S+ 0 0 104 -4,-1.5 2,-0.3 -5,-0.3 -4,-0.2 0.931 75.8 114.5 52.6 54.2 29.4 -2.4 9.2 26 38 A E - 0 0 85 -6,-0.5 2,-0.8 -9,-0.2 -2,-0.2 -0.987 68.8-122.5-150.9 148.8 29.7 -0.3 12.3 27 39 A F - 0 0 73 -2,-0.3 2,-0.6 -3,-0.1 120,-0.1 -0.887 28.7-168.5-100.5 109.6 27.5 0.5 15.3 28 40 A V - 0 0 38 -2,-0.8 3,-0.5 -11,-0.2 2,-0.3 -0.884 9.0-153.2-102.6 115.6 27.1 4.3 15.4 29 41 A E + 0 0 135 -2,-0.6 -2,-0.0 1,-0.2 118,-0.0 -0.655 66.9 0.8 -95.4 144.8 25.5 5.4 18.7 30 42 A D S S- 0 0 158 -2,-0.3 -1,-0.2 1,-0.2 2,-0.1 0.843 75.5-170.7 49.0 42.9 23.4 8.6 19.2 31 43 A Y - 0 0 48 -3,-0.5 -1,-0.2 1,-0.2 -15,-0.1 -0.445 51.7 -73.1 -57.3 135.6 23.6 9.7 15.5 32 44 A E > - 0 0 111 1,-0.1 3,-1.5 2,-0.1 -1,-0.2 -0.083 49.3-145.3 -40.4 112.7 22.2 13.2 15.4 33 45 A P T 3 S+ 0 0 95 0, 0.0 27,-0.2 0, 0.0 -1,-0.1 0.826 94.3 43.9 -55.3 -39.9 18.4 12.5 15.9 34 46 A T T 3 S+ 0 0 39 25,-0.1 2,-0.5 26,-0.1 24,-0.2 0.305 92.9 104.7 -91.8 7.1 17.2 15.3 13.6 35 47 A K < - 0 0 89 -3,-1.5 2,-0.3 23,-0.1 -4,-0.0 -0.803 50.4-167.5 -96.8 126.4 19.7 14.6 10.9 36 48 A A + 0 0 47 -2,-0.5 2,-0.3 21,-0.0 21,-0.2 -0.803 9.3 173.7-104.4 150.3 18.7 12.9 7.6 37 49 A D E -C 56 0A 68 19,-1.5 19,-2.7 -2,-0.3 2,-0.4 -0.986 24.1-134.4-151.8 155.1 21.0 11.4 5.0 38 50 A S E -C 55 0A 73 -2,-0.3 2,-0.3 17,-0.2 17,-0.2 -0.889 23.4-169.0-108.2 139.7 20.8 9.4 1.8 39 51 A Y E -C 54 0A 18 15,-2.9 15,-2.6 -2,-0.4 2,-0.3 -0.892 8.0-174.2-127.9 156.3 23.1 6.5 1.1 40 52 A R E +C 53 0A 136 -2,-0.3 2,-0.3 13,-0.2 13,-0.2 -0.972 10.2 162.5-150.5 132.4 23.9 4.3 -1.9 41 53 A K E -C 52 0A 54 11,-1.8 11,-2.7 -2,-0.3 2,-0.4 -0.991 36.6-113.9-149.4 153.9 26.0 1.2 -2.3 42 54 A K E +C 51 0A 147 -2,-0.3 2,-0.3 9,-0.2 9,-0.2 -0.703 39.6 174.3 -83.6 134.1 26.5 -1.6 -4.7 43 55 A V E -C 50 0A 14 7,-3.1 7,-2.8 -2,-0.4 2,-0.8 -0.947 35.5-119.1-134.9 158.5 25.5 -5.0 -3.4 44 56 A V E -C 49 0A 92 -2,-0.3 2,-0.7 5,-0.2 5,-0.2 -0.904 31.6-172.6 -98.4 110.7 25.3 -8.5 -4.9 45 57 A L E > S-C 48 0A 2 3,-2.8 3,-1.9 -2,-0.8 -2,-0.0 -0.925 70.5 -30.2-108.7 110.2 21.7 -9.6 -4.5 46 58 A D T 3 S- 0 0 91 -2,-0.7 -1,-0.2 1,-0.3 3,-0.1 0.911 127.5 -43.5 43.9 55.3 21.2 -13.2 -5.5 47 59 A G T 3 S+ 0 0 61 1,-0.1 2,-0.5 -3,-0.1 -1,-0.3 0.150 119.1 104.2 87.2 -18.7 24.0 -13.2 -8.1 48 60 A E E < S- C 0 45A 143 -3,-1.9 -3,-2.8 1,-0.0 2,-0.4 -0.856 70.5-126.0-107.2 129.1 23.1 -9.8 -9.6 49 61 A E E + C 0 44A 140 -2,-0.5 2,-0.3 -5,-0.2 -5,-0.2 -0.551 44.3 160.3 -64.2 121.2 25.0 -6.5 -9.0 50 62 A V E - C 0 43A 14 -7,-2.8 -7,-3.1 -2,-0.4 2,-0.4 -0.908 35.5-123.2-136.9 165.1 22.4 -3.9 -7.9 51 63 A Q E -aC 2 42A 64 -50,-3.2 -48,-2.7 -2,-0.3 2,-0.4 -0.937 17.6-154.1-110.5 138.0 22.5 -0.6 -6.1 52 64 A I E -aC 3 41A 0 -11,-2.7 -11,-1.8 -2,-0.4 2,-0.5 -0.885 4.3-161.4-103.7 140.8 20.6 0.1 -2.9 53 65 A D E -aC 4 40A 21 -50,-2.8 -48,-3.9 -2,-0.4 2,-0.5 -0.996 8.0-169.1-119.7 127.6 19.5 3.6 -2.0 54 66 A I E -aC 5 39A 0 -15,-2.6 -15,-2.9 -2,-0.5 2,-0.8 -0.972 12.0-161.4-121.2 122.8 18.6 4.3 1.6 55 67 A L E -aC 6 38A 29 -50,-2.6 -48,-2.8 -2,-0.5 2,-1.2 -0.908 8.3-160.2 -96.8 107.0 17.0 7.4 2.8 56 68 A D E -aC 7 37A 0 -19,-2.7 -19,-1.5 -2,-0.8 2,-0.1 -0.766 21.0-152.5 -82.9 94.1 17.5 7.5 6.5 57 69 A T - 0 0 2 -2,-1.2 -22,-0.1 -50,-0.7 -41,-0.1 -0.406 23.1-165.1 -72.1 144.0 14.7 10.0 7.4 58 70 A A - 0 0 7 -24,-0.2 -1,-0.2 -2,-0.1 -23,-0.1 0.889 21.3-174.9 -83.1 -66.3 14.9 12.3 10.4 59 71 A G > + 0 0 0 -25,-0.2 165,-2.8 164,-0.1 3,-0.8 0.166 48.7 106.8 101.6 -16.1 11.2 13.1 10.2 60 72 A Q T 3 S+ 0 0 5 163,-0.3 -26,-0.1 1,-0.2 162,-0.0 0.750 98.4 24.7 -67.7 -22.4 10.8 15.7 12.9 61 73 A E T 3 S+ 0 0 56 -27,-0.1 2,-1.7 2,-0.1 -1,-0.2 0.118 85.4 124.1-128.8 18.8 10.4 18.4 10.3 62 74 A D < - 0 0 24 -3,-0.8 5,-0.1 4,-0.1 -1,-0.0 -0.608 46.6-167.1 -89.4 81.0 9.2 16.4 7.3 63 75 A Y > - 0 0 16 -2,-1.7 4,-2.5 3,-0.1 3,-0.4 0.006 39.5 -79.9 -61.4 170.0 6.0 18.3 6.6 64 76 A A H > S+ 0 0 25 1,-0.2 4,-2.6 2,-0.2 5,-0.3 0.854 129.5 46.3 -40.0 -57.3 3.2 17.0 4.2 65 77 A A H > S+ 0 0 78 1,-0.2 4,-1.9 2,-0.2 -1,-0.2 0.888 116.3 45.6 -57.1 -44.8 5.0 18.0 1.0 66 78 A I H > S+ 0 0 79 -3,-0.4 4,-2.2 2,-0.2 5,-0.2 0.957 116.9 40.3 -64.6 -54.7 8.3 16.5 2.0 67 79 A R H X S+ 0 0 0 -4,-2.5 4,-2.5 1,-0.2 5,-0.2 0.884 114.5 53.4 -69.1 -36.1 7.2 13.2 3.4 68 80 A D H X S+ 0 0 30 -4,-2.6 4,-2.4 -5,-0.4 -1,-0.2 0.933 108.6 52.1 -61.8 -43.9 4.6 12.7 0.6 69 81 A N H X S+ 0 0 105 -4,-1.9 4,-2.2 -5,-0.3 -2,-0.2 0.936 114.4 39.5 -57.1 -52.0 7.4 13.3 -1.9 70 82 A Y H X S+ 0 0 17 -4,-2.2 4,-2.4 2,-0.2 -1,-0.2 0.811 112.6 55.6 -76.8 -25.5 9.8 10.7 -0.5 71 83 A F H < S+ 0 0 0 -4,-2.5 -1,-0.2 -5,-0.2 -2,-0.2 0.911 111.3 47.0 -63.0 -42.0 7.0 8.2 0.2 72 84 A R H < S+ 0 0 138 -4,-2.4 -2,-0.2 -5,-0.2 -1,-0.2 0.906 117.1 40.9 -65.8 -43.7 6.1 8.5 -3.5 73 85 A S H < S+ 0 0 44 -4,-2.2 -2,-0.2 -5,-0.2 -1,-0.2 0.846 96.3 94.2 -76.0 -33.9 9.7 8.1 -4.7 74 86 A G < - 0 0 1 -4,-2.4 -69,-0.2 -5,-0.2 3,-0.1 -0.322 54.8-167.4 -60.2 138.3 10.5 5.4 -2.2 75 87 A E + 0 0 57 -71,-2.4 2,-0.3 1,-0.3 -70,-0.2 0.700 70.0 19.5-101.6 -26.2 10.1 1.9 -3.5 76 88 A G E -b 5 0A 0 -72,-1.9 -70,-2.7 32,-0.1 2,-0.4 -0.989 68.2-143.2-146.6 154.6 10.3 -0.1 -0.3 77 89 A F E -bd 6 110A 0 32,-1.9 34,-2.6 -2,-0.3 2,-0.8 -0.964 9.7-159.6-128.9 128.0 10.0 0.7 3.4 78 90 A L E -bd 7 111A 0 -72,-2.3 -70,-2.7 -2,-0.4 2,-1.0 -0.931 19.5-161.9 -96.0 107.5 11.7 -0.5 6.5 79 91 A C E -bd 8 112A 0 32,-2.9 34,-3.1 -2,-0.8 2,-0.4 -0.806 16.1-167.0 -96.3 101.5 9.2 0.4 9.2 80 92 A V E + d 0 113A 0 -72,-3.0 -70,-0.4 -2,-1.0 2,-0.3 -0.732 18.3 165.8 -99.6 133.4 11.2 0.3 12.3 81 93 A F E - d 0 114A 0 32,-2.7 34,-3.1 -2,-0.4 2,-0.5 -0.882 36.9-112.8-125.2 170.6 10.1 0.3 15.9 82 94 A S E > - d 0 115A 1 3,-0.4 3,-2.0 -2,-0.3 7,-0.3 -0.907 12.6-142.0-102.2 132.8 12.1 -0.5 19.1 83 95 A I T 3 S+ 0 0 0 32,-2.7 41,-3.3 -2,-0.5 42,-2.3 0.678 103.5 57.7 -63.2 -15.0 11.1 -3.6 21.0 84 96 A T T 3 S+ 0 0 20 31,-0.3 2,-0.4 39,-0.3 -1,-0.3 0.400 100.7 62.5 -94.1 0.9 11.7 -1.6 24.2 85 97 A E X> - 0 0 61 -3,-2.0 4,-1.4 1,-0.1 3,-0.7 -0.839 55.3-173.9-134.7 98.3 9.2 1.1 23.3 86 98 A M H 3> S+ 0 0 65 -2,-0.4 4,-3.0 1,-0.2 5,-0.2 0.849 88.2 61.5 -54.9 -38.8 5.6 0.2 22.9 87 99 A E H 3> S+ 0 0 98 1,-0.2 4,-2.2 2,-0.2 -1,-0.2 0.891 103.0 50.7 -57.7 -38.7 4.8 3.8 21.8 88 100 A S H <> S+ 0 0 4 -3,-0.7 4,-0.6 2,-0.2 -78,-0.3 0.849 110.3 49.1 -69.0 -35.2 7.1 3.2 18.8 89 101 A F H >< S+ 0 0 0 -4,-1.4 3,-1.2 -7,-0.3 4,-0.5 0.933 109.9 51.5 -65.4 -47.1 5.3 -0.0 17.9 90 102 A A H >< S+ 0 0 39 -4,-3.0 3,-1.2 1,-0.2 4,-0.4 0.913 105.4 57.2 -53.6 -44.2 2.0 1.7 18.2 91 103 A A H >X S+ 0 0 0 -4,-2.2 4,-1.6 1,-0.2 3,-1.0 0.684 84.3 81.2 -63.7 -20.4 3.2 4.4 15.8 92 104 A T H S+ 0 0 37 -3,-1.2 4,-2.3 -4,-0.5 -1,-0.3 0.845 104.4 51.9 -60.0 -36.1 0.4 1.9 12.0 94 106 A D H <> S+ 0 0 33 -3,-1.0 4,-2.2 -4,-0.4 -2,-0.2 0.904 109.3 46.7 -68.5 -47.5 0.6 5.7 11.4 95 107 A F H X S+ 0 0 1 -4,-1.6 4,-2.5 1,-0.2 -2,-0.2 0.949 115.0 48.1 -61.2 -46.3 3.7 5.5 9.1 96 108 A R H X S+ 0 0 37 -4,-2.5 4,-3.2 1,-0.2 5,-0.2 0.907 109.7 52.2 -61.4 -43.3 2.1 2.7 7.2 97 109 A E H X S+ 0 0 73 -4,-2.3 4,-2.2 1,-0.2 -1,-0.2 0.928 112.7 44.7 -58.4 -46.7 -1.2 4.5 6.8 98 110 A Q H X S+ 0 0 3 -4,-2.2 4,-1.3 2,-0.2 -1,-0.2 0.847 113.8 50.1 -68.5 -35.4 0.6 7.6 5.5 99 111 A I H X S+ 0 0 0 -4,-2.5 4,-2.5 -5,-0.2 3,-0.4 0.954 112.6 47.1 -63.5 -49.9 2.7 5.5 3.2 100 112 A L H X S+ 0 0 25 -4,-3.2 4,-2.0 1,-0.2 5,-0.3 0.840 107.0 58.6 -61.8 -35.5 -0.4 3.7 1.9 101 113 A R H < S+ 0 0 152 -4,-2.2 -1,-0.2 -5,-0.2 -2,-0.2 0.876 114.7 34.5 -61.7 -40.3 -2.2 7.0 1.4 102 114 A V H < S+ 0 0 20 -4,-1.3 -2,-0.2 -3,-0.4 -1,-0.2 0.855 123.4 41.8 -84.3 -37.8 0.4 8.3 -1.0 103 115 A K H < S- 0 0 51 -4,-2.5 -3,-0.2 -5,-0.2 -2,-0.2 0.721 84.5-154.5 -85.6 -22.0 1.4 5.1 -2.8 104 116 A E < + 0 0 166 -4,-2.0 2,-0.3 -5,-0.3 -3,-0.1 0.871 59.4 109.5 48.1 44.0 -2.2 3.8 -3.1 105 117 A D > - 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