==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=25-NOV-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER PROTEINASE INHIBITOR 28-AUG-98 1BR9 . COMPND 2 MOLECULE: METALLOPROTEINASE-2 INHIBITOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR A.TUUTTILA,E.MORGUNOVA,U.BERGMANN,Y.LINDQVIST,K.TRYGGVASON, . 182 1 6 6 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 10201.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 112 61.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 9 4.9 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 44 24.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 3 1.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 18 9.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 16 8.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 16 8.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 3 1.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 2 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 2 2 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A a 0 0 74 0, 0.0 2,-0.4 0, 0.0 70,-0.1 0.000 360.0 360.0 360.0 121.4 36.8 31.3 18.6 2 2 A S - 0 0 120 99,-0.0 2,-0.3 2,-0.0 99,-0.1 -0.987 360.0-177.8-126.5 134.7 35.7 28.9 21.4 3 3 A b - 0 0 56 -2,-0.4 3,-0.0 97,-0.1 99,-0.0 -0.897 26.3-118.2-126.2 142.2 32.5 27.0 21.5 4 4 A S - 0 0 97 -2,-0.3 2,-0.1 1,-0.1 -2,-0.0 -0.576 43.1 -99.5 -77.2 147.9 30.8 24.6 23.9 5 5 A P - 0 0 60 0, 0.0 2,-0.4 0, 0.0 127,-0.1 -0.442 41.9-168.7 -61.7 135.5 30.1 21.1 22.7 6 6 A V - 0 0 57 -2,-0.1 125,-0.1 151,-0.1 -3,-0.0 -0.997 24.5-120.6-129.2 125.4 26.5 20.6 21.6 7 7 A H > - 0 0 2 -2,-0.4 4,-2.3 123,-0.2 3,-0.3 -0.428 33.9-115.5 -59.2 143.9 24.8 17.3 20.8 8 8 A P H > S+ 0 0 10 0, 0.0 4,-2.3 0, 0.0 5,-0.1 0.840 115.3 51.8 -55.0 -37.9 23.6 17.4 17.1 9 9 A Q H > S+ 0 0 0 156,-0.2 4,-2.9 2,-0.2 5,-0.2 0.908 108.9 50.7 -60.7 -46.1 20.0 17.2 18.1 10 10 A Q H > S+ 0 0 28 -3,-0.3 4,-2.3 1,-0.2 -1,-0.2 0.866 110.8 48.5 -67.3 -35.6 20.3 20.1 20.6 11 11 A A H X S+ 0 0 13 -4,-2.3 4,-2.0 2,-0.2 -1,-0.2 0.925 111.7 50.9 -62.8 -45.3 22.0 22.2 17.9 12 12 A F H < S+ 0 0 3 -4,-2.3 -2,-0.2 -5,-0.2 3,-0.2 0.969 114.1 43.7 -53.7 -50.3 19.1 21.2 15.5 13 13 A c H < S+ 0 0 19 -4,-2.9 -2,-0.2 1,-0.2 -1,-0.2 0.895 115.0 47.5 -70.0 -37.5 16.5 22.2 18.0 14 14 A N H < S+ 0 0 108 -4,-2.3 -1,-0.2 -5,-0.2 -2,-0.2 0.774 94.7 90.7 -72.8 -29.1 18.2 25.5 19.1 15 15 A A S < S- 0 0 16 -4,-2.0 74,-0.2 -3,-0.2 3,-0.1 -0.346 71.2-140.7 -69.4 149.2 18.8 26.7 15.6 16 16 A D S S+ 0 0 83 72,-1.2 2,-0.3 1,-0.2 73,-0.2 0.877 87.1 14.3 -67.1 -42.0 16.3 28.9 13.8 17 17 A V E -A 88 0A 0 71,-2.0 71,-2.1 38,-0.2 2,-0.4 -0.997 60.3-168.2-145.5 141.5 16.9 27.2 10.5 18 18 A V E +AB 87 54A 0 36,-2.1 35,-2.7 -2,-0.3 36,-1.3 -0.998 21.2 160.5-136.1 121.8 18.6 24.0 9.3 19 19 A I E -AB 86 52A 0 67,-2.0 67,-2.9 -2,-0.4 2,-0.5 -0.945 40.6-124.6-138.5 156.7 19.3 23.2 5.7 20 20 A R E +AB 85 51A 64 31,-2.7 30,-2.8 -2,-0.3 31,-1.6 -0.953 52.7 159.5 -98.8 131.0 21.4 21.1 3.4 21 21 A A E -AB 84 49A 1 63,-2.4 63,-2.5 -2,-0.5 2,-0.4 -0.969 39.3-145.4-153.5 155.2 23.3 23.4 1.1 22 22 A K E -AB 83 48A 68 26,-1.8 26,-2.7 -2,-0.3 2,-0.5 -0.971 27.6-124.3-128.1 149.3 26.2 24.2 -1.2 23 23 A A E + B 0 47A 1 59,-0.6 56,-1.8 54,-0.4 57,-1.7 -0.811 25.3 178.1 -95.7 130.9 27.9 27.6 -1.6 24 24 A V E - 0 0 68 22,-3.4 2,-0.3 -2,-0.5 23,-0.2 0.730 63.5 -2.3-105.1 -41.4 27.9 28.9 -5.2 25 25 A S E - B 0 46A 39 21,-1.3 21,-3.2 54,-0.1 2,-0.4 -0.993 57.9-146.6-152.1 167.8 29.7 32.3 -4.7 26 26 A E E + B 0 45A 101 -2,-0.3 2,-0.3 19,-0.2 19,-0.2 -0.991 18.7 159.6-136.2 130.2 31.2 34.6 -2.2 27 27 A K E - B 0 44A 124 17,-1.9 17,-3.5 -2,-0.4 2,-0.4 -0.982 38.1-113.7-144.1 161.1 31.5 38.3 -1.6 28 28 A E E - B 0 43A 113 -2,-0.3 2,-0.3 15,-0.2 15,-0.2 -0.750 41.4-176.0 -86.3 131.1 32.2 40.7 1.2 29 29 A V E - B 0 42A 30 13,-3.1 13,-2.4 -2,-0.4 2,-0.5 -0.875 32.3-115.7-126.9 161.8 29.3 43.0 2.0 30 30 A D E - B 0 41A 97 -2,-0.3 11,-0.2 11,-0.2 3,-0.1 -0.890 26.9-171.8 -88.2 121.6 28.3 45.9 4.3 31 31 A S E - 0 0 40 9,-3.1 2,-0.2 -2,-0.5 10,-0.1 0.209 49.8 -80.9-106.4 17.2 25.6 44.6 6.6 32 32 A G E - 0 0 28 8,-0.1 8,-2.7 5,-0.0 -1,-0.4 -0.612 59.9 -60.0 115.2-175.3 24.6 47.9 8.3 33 33 A N E - B 0 39A 107 6,-0.3 2,-0.0 -2,-0.2 -3,-0.0 -0.821 45.9-128.5-105.4 147.4 26.1 49.9 11.1 34 34 A D > - 0 0 59 4,-3.1 3,-2.2 -2,-0.3 -1,-0.1 -0.109 47.5 -76.4 -75.2-169.6 26.6 48.6 14.7 35 35 A I T 3 S+ 0 0 155 1,-0.3 -1,-0.1 2,-0.1 -2,-0.0 0.775 133.7 52.0 -65.1 -27.8 25.3 50.4 17.8 36 36 A Y T 3 S- 0 0 189 2,-0.1 -1,-0.3 3,-0.0 -2,-0.0 0.315 122.8-102.7 -88.4 4.9 28.3 52.8 17.5 37 37 A G S < S+ 0 0 44 -3,-2.2 -2,-0.1 1,-0.3 -5,-0.0 0.637 77.4 138.6 83.1 15.6 27.6 53.7 13.9 38 38 A N - 0 0 92 1,-0.1 -4,-3.1 0, 0.0 -1,-0.3 -0.812 58.6-107.3 -99.7 130.3 30.4 51.5 12.6 39 39 A P E -B 33 0A 72 0, 0.0 2,-0.7 0, 0.0 -6,-0.3 -0.091 25.3-134.2 -48.5 145.4 29.8 49.4 9.5 40 40 A I E - 0 0 69 -8,-2.7 -9,-3.1 -6,-0.0 2,-0.3 -0.912 17.7-153.2-109.5 108.9 29.4 45.6 9.9 41 41 A K E +B 30 0A 88 -2,-0.7 2,-0.3 -11,-0.2 -11,-0.2 -0.647 21.4 170.1 -82.8 128.8 31.5 43.7 7.4 42 42 A R E -B 29 0A 29 -13,-2.4 -13,-3.1 -2,-0.3 2,-0.5 -0.984 36.3-119.7-132.1 154.9 30.3 40.2 6.5 43 43 A I E -BC 28 65A 12 22,-3.4 22,-1.7 -2,-0.3 2,-0.6 -0.794 28.3-153.3 -81.0 132.3 31.0 37.4 4.0 44 44 A Q E -BC 27 64A 24 -17,-3.5 -17,-1.9 -2,-0.5 2,-0.6 -0.926 6.4-162.9-106.3 108.8 27.9 36.7 2.0 45 45 A Y E -BC 26 63A 11 18,-3.8 18,-2.7 -2,-0.6 2,-0.4 -0.871 10.2-146.6 -89.8 124.3 27.8 33.1 0.6 46 46 A E E -BC 25 62A 84 -21,-3.2 -22,-3.4 -2,-0.6 -21,-1.3 -0.761 31.2-172.6 -79.1 129.1 25.3 32.7 -2.2 47 47 A I E -B 23 0A 15 14,-2.1 2,-0.6 -2,-0.4 -24,-0.2 -0.842 34.1-131.9-124.2 162.3 23.9 29.1 -1.9 48 48 A K E -B 22 0A 117 -26,-2.7 -26,-1.8 -2,-0.3 2,-0.6 -0.979 30.1-141.4-100.8 111.2 21.8 26.5 -3.5 49 49 A Q E -B 21 0A 28 -2,-0.6 -28,-0.2 11,-0.4 3,-0.1 -0.728 20.2-177.7 -68.5 117.1 19.4 25.2 -0.8 50 50 A I E - 0 0 61 -30,-2.8 2,-0.3 -2,-0.6 -29,-0.2 0.857 68.7 -12.5 -80.8 -39.5 19.2 21.4 -1.4 51 51 A K E -B 20 0A 93 -31,-1.6 -31,-2.7 0, 0.0 2,-0.5 -0.975 56.0-140.7-162.2 138.6 16.6 20.9 1.4 52 52 A M E +B 19 0A 42 -2,-0.3 -33,-0.2 -33,-0.2 3,-0.1 -0.946 14.4 180.0-101.8 128.4 15.2 22.7 4.3 53 53 A F E S- 0 0 29 -35,-2.7 2,-0.3 -2,-0.5 -34,-0.2 0.699 70.7 -12.8 -97.0 -24.3 14.6 20.6 7.5 54 54 A K E S+B 18 0A 40 -36,-1.3 -36,-2.1 2,-0.1 -1,-0.4 -0.938 88.7 77.7-170.6 159.8 13.2 23.4 9.6 55 55 A G S S- 0 0 36 -2,-0.3 -38,-0.2 -38,-0.2 -3,-0.0 -0.610 83.9 -23.6 124.5 175.7 12.9 27.2 9.7 56 56 A P - 0 0 62 0, 0.0 -2,-0.1 0, 0.0 36,-0.0 -0.166 67.0-114.8 -51.6 155.2 10.7 29.8 8.0 57 57 A E S S+ 0 0 184 2,-0.1 2,-0.4 -5,-0.0 3,-0.1 0.716 88.0 98.0 -82.8 -17.6 9.2 28.6 4.7 58 58 A K S S- 0 0 96 1,-0.1 36,-0.2 0, 0.0 34,-0.1 -0.566 84.9-110.7 -65.5 120.0 11.0 31.0 2.4 59 59 A D - 0 0 100 -2,-0.4 2,-0.4 1,-0.1 -1,-0.1 -0.134 27.5-111.4 -51.0 144.1 14.0 29.2 1.0 60 60 A I + 0 0 7 1,-0.2 -11,-0.4 -3,-0.1 35,-0.2 -0.664 42.4 162.7 -77.1 127.6 17.5 30.3 2.1 61 61 A E + 0 0 96 33,-3.0 -14,-2.1 -2,-0.4 2,-0.4 0.530 63.2 39.4-112.7 -23.7 19.5 32.0 -0.7 62 62 A F E -Cd 46 95A 47 32,-2.0 34,-1.9 -16,-0.2 2,-0.4 -0.997 57.0-165.6-132.0 139.1 22.2 33.7 1.3 63 63 A I E -Cd 45 96A 0 -18,-2.7 -18,-3.8 -2,-0.4 2,-0.3 -0.973 14.8-159.6-120.5 128.0 24.3 32.7 4.3 64 64 A Y E +Cd 44 97A 20 32,-3.3 34,-2.4 -2,-0.4 2,-0.3 -0.804 17.1 160.2-110.2 155.4 26.3 35.4 6.1 65 65 A T E -C 43 0A 0 -22,-1.7 -22,-3.4 -2,-0.3 8,-0.1 -0.978 43.8 -78.2-167.0 157.6 29.3 35.0 8.4 66 66 A A - 0 0 22 32,-0.5 8,-0.2 -2,-0.3 -24,-0.1 -0.269 40.3-120.2 -62.8 148.0 32.3 37.0 9.9 67 67 A P S S+ 0 0 66 0, 0.0 2,-0.4 0, 0.0 -1,-0.1 0.844 92.5 43.5 -51.3 -35.7 35.3 37.6 7.6 68 68 A S > > - 0 0 55 1,-0.1 5,-2.9 3,-0.0 3,-1.4 -0.915 66.0-140.2-126.9 143.3 37.6 35.7 10.0 69 69 A S G > 5S+ 0 0 75 -2,-0.4 3,-2.0 3,-0.3 -1,-0.1 0.741 98.9 79.9 -59.8 -21.4 37.7 32.5 12.1 70 70 A A G 3 5S+ 0 0 75 1,-0.3 -1,-0.3 2,-0.1 0, 0.0 0.830 105.3 30.8 -58.1 -32.3 39.4 34.7 14.7 71 71 A V G < 5S- 0 0 104 -3,-1.4 -1,-0.3 -70,-0.1 -2,-0.2 -0.108 135.0 -86.3-114.1 34.2 36.0 36.0 15.6 72 72 A a T < 5S+ 0 0 29 -3,-2.0 28,-2.1 1,-0.2 -3,-0.3 0.632 71.0 160.6 76.4 19.8 34.2 32.7 14.7 73 73 A G < - 0 0 2 -5,-2.9 2,-0.4 26,-0.2 -1,-0.2 -0.329 33.6-129.0 -62.7 152.7 33.6 33.3 10.9 74 74 A V - 0 0 8 24,-0.3 2,-0.5 -8,-0.2 24,-0.1 -0.856 7.7-142.7-108.4 136.3 32.9 30.1 8.9 75 75 A S - 0 0 103 -2,-0.4 2,-0.4 -6,-0.0 -7,-0.0 -0.910 15.4-172.2 -96.4 125.4 34.6 28.9 5.7 76 76 A L - 0 0 10 -2,-0.5 2,-1.1 -54,-0.0 -54,-0.0 -0.943 31.0-119.7-112.0 138.2 32.5 27.2 3.1 77 77 A D - 0 0 67 -2,-0.4 -54,-0.4 5,-0.0 5,-0.3 -0.708 38.8-155.2 -79.0 101.2 34.2 25.6 0.1 78 78 A V + 0 0 40 -2,-1.1 -54,-0.2 1,-0.1 4,-0.1 -0.442 58.5 81.2 -77.6 155.5 32.6 27.6 -2.7 79 79 A G S S- 0 0 53 -56,-1.8 -55,-0.2 -2,-0.1 -1,-0.1 0.607 112.0 -76.6 123.3 31.8 32.3 26.4 -6.3 80 80 A G S S+ 0 0 30 -57,-1.7 -56,-0.1 1,-0.1 -2,-0.1 0.467 108.1 105.3 67.9 6.1 29.2 24.2 -6.1 81 81 A K + 0 0 122 -4,-0.3 -3,-0.1 -58,-0.3 -1,-0.1 0.894 55.6 49.2 -88.7 -96.5 31.3 21.5 -4.5 82 82 A K - 0 0 109 -5,-0.3 -59,-0.6 1,-0.1 2,-0.4 -0.135 65.4-149.7 -61.1 132.2 31.1 20.6 -0.8 83 83 A E E -A 22 0A 55 -61,-0.1 24,-3.2 -7,-0.0 25,-0.4 -0.821 17.2-167.1 -94.1 142.2 27.6 20.1 0.6 84 84 A Y E -AE 21 106A 22 -63,-2.5 -63,-2.4 -2,-0.4 2,-0.6 -0.946 28.4-132.8-128.5 142.7 27.0 21.0 4.2 85 85 A L E -AE 20 105A 0 20,-3.0 20,-1.8 -2,-0.4 2,-0.5 -0.873 40.7-169.5 -82.7 123.9 24.3 20.4 6.9 86 86 A I E -AE 19 104A 1 -67,-2.9 -67,-2.0 -2,-0.6 2,-0.4 -0.962 16.8-177.6-129.4 118.7 24.1 24.0 8.2 87 87 A A E +A 18 0A 1 16,-2.8 2,-0.3 -2,-0.5 -69,-0.2 -0.906 29.8 116.5-112.6 138.1 22.2 25.1 11.3 88 88 A G E -A 17 0A 2 -71,-2.1 -71,-2.0 -2,-0.4 -72,-1.2 -0.950 57.6 -39.7-173.8-170.2 22.0 28.8 12.2 89 89 A K E -F 97 0A 116 8,-2.1 8,-2.1 -2,-0.3 2,-0.5 -0.655 45.3-138.5 -82.5 130.3 20.2 32.0 12.8 90 90 A A E -F 96 0A 21 -2,-0.4 6,-0.2 6,-0.2 3,-0.1 -0.775 18.2-178.1 -89.3 127.2 17.3 33.0 10.5 91 91 A E E - 0 0 58 4,-2.2 5,-0.1 -2,-0.5 -1,-0.1 0.395 45.9-117.2 -96.2 -1.5 17.3 36.7 9.6 92 92 A G E > S+F 95 0A 34 3,-0.6 3,-1.4 -34,-0.1 -1,-0.3 -0.101 90.0 72.8 82.1 165.3 14.1 36.3 7.5 93 93 A D T 3 S- 0 0 110 1,-0.3 -32,-0.1 -3,-0.1 3,-0.1 0.757 128.0 -61.4 71.8 28.4 14.0 37.0 3.8 94 94 A G T 3 S+ 0 0 3 -36,-0.2 -33,-3.0 1,-0.2 -32,-2.0 0.757 107.6 123.1 64.3 24.9 15.9 33.9 2.8 95 95 A K E < -dF 62 92A 57 -3,-1.4 -4,-2.2 -35,-0.2 -3,-0.6 -0.913 36.3-178.3-116.5 143.7 19.0 34.9 4.8 96 96 A M E -dF 63 90A 0 -34,-1.9 -32,-3.3 -2,-0.4 2,-0.4 -0.945 15.1-145.9-133.3 161.2 20.9 33.2 7.5 97 97 A H E -dF 64 89A 46 -8,-2.1 -8,-2.1 -2,-0.3 2,-0.3 -0.998 18.0-171.6-126.9 130.6 23.9 34.0 9.7 98 98 A I - 0 0 0 -34,-2.4 -32,-0.5 -2,-0.4 -24,-0.3 -0.882 10.1-174.5-124.8 149.7 26.4 31.4 11.0 99 99 A T > - 0 0 42 -2,-0.3 3,-2.3 -34,-0.1 -26,-0.2 -0.899 45.8 -99.5-127.9 163.8 29.3 31.3 13.4 100 100 A L T 3 S+ 0 0 83 -28,-2.1 4,-0.2 -2,-0.3 -97,-0.1 0.649 120.3 63.1 -61.7 -16.7 31.7 28.4 14.1 101 101 A b T 3 S+ 0 0 51 -29,-0.2 -1,-0.3 -99,-0.1 2,-0.1 0.430 87.7 90.7 -84.3 -5.4 29.7 27.5 17.3 102 102 A D S < S- 0 0 53 -3,-2.3 2,-0.9 1,-0.1 -14,-0.1 -0.405 98.4 -91.6 -75.1 168.0 26.7 26.7 15.1 103 103 A F + 0 0 30 -16,-0.2 -16,-2.8 -92,-0.1 2,-0.4 -0.751 61.6 154.7 -88.2 106.0 26.3 23.1 13.7 104 104 A I E +E 86 0A 38 -2,-0.9 -18,-0.2 -18,-0.2 -20,-0.0 -0.935 7.6 150.9-137.6 105.7 28.1 23.1 10.4 105 105 A V E -E 85 0A 38 -20,-1.8 -20,-3.0 -2,-0.4 5,-0.1 -0.989 52.3 -91.2-135.7 144.0 29.4 19.8 9.0 106 106 A P E > -E 84 0A 38 0, 0.0 3,-1.9 0, 0.0 4,-0.4 -0.309 38.2-124.8 -49.9 133.7 30.0 18.4 5.5 107 107 A W G > S+ 0 0 24 -24,-3.2 3,-1.4 1,-0.3 -23,-0.2 0.890 106.9 55.1 -52.0 -42.6 26.9 16.5 4.4 108 108 A D G 3 S+ 0 0 125 -25,-0.4 -1,-0.3 1,-0.3 -24,-0.1 0.467 97.4 63.6 -77.8 -3.1 28.8 13.2 3.7 109 109 A T G < S+ 0 0 94 -3,-1.9 -1,-0.3 2,-0.1 -2,-0.2 0.465 80.0 104.4 -96.3 -5.8 30.3 13.0 7.2 110 110 A L S < S- 0 0 10 -3,-1.4 2,-0.1 -4,-0.4 53,-0.1 -0.482 76.7-114.7 -70.8 144.2 26.8 12.6 8.9 111 111 A S > - 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