==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=28-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 02-SEP-05 2C0H . COMPND 2 MOLECULE: MANNAN ENDO-1,4-BETA-MANNOSIDASE; . SOURCE 2 ORGANISM_SCIENTIFIC: MYTILUS EDULIS; . AUTHOR A.M.LARSSON,L.ANDERSON,B.XU,I.G.MUNOZ,I.USON,J.-C.JANSON, . 353 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 13341.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 240 68.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 47 13.3 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 17 4.8 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 3 0.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 19 5.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 48 13.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 84 23.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 5 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 2 1 3 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 2 2 2 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 2 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 15 A A 0 0 158 0, 0.0 2,-0.1 0, 0.0 3,-0.0 0.000 360.0 360.0 360.0 8.1 46.2 45.1 -12.7 2 16 A A - 0 0 80 1,-0.1 2,-0.4 13,-0.0 13,-0.0 -0.410 360.0-113.7 -63.1 139.1 43.5 47.6 -11.6 3 17 A V + 0 0 99 1,-0.1 12,-0.2 -2,-0.1 3,-0.1 -0.627 40.3 174.1 -75.9 129.6 42.5 47.2 -7.9 4 18 A R + 0 0 60 1,-0.4 11,-1.8 -2,-0.4 12,-0.5 0.701 58.6 19.0-102.9 -97.2 38.9 46.0 -7.6 5 19 A L E S+A 14 0A 15 9,-0.2 -1,-0.4 10,-0.1 2,-0.3 -0.625 77.2 156.6 -81.0 131.4 37.5 45.1 -4.1 6 20 A S E -A 13 0A 34 7,-2.7 7,-3.0 -2,-0.3 2,-0.4 -0.941 35.8-119.2-146.6 168.9 39.6 46.5 -1.2 7 21 A V E -A 12 0A 50 -2,-0.3 2,-0.4 5,-0.2 5,-0.2 -0.943 17.2-177.2-114.1 136.2 39.4 47.5 2.5 8 22 A S E > -A 11 0A 73 3,-2.7 3,-2.2 -2,-0.4 2,-0.4 -0.917 66.7 -59.0-129.1 105.2 40.0 51.0 4.0 9 23 A G T 3 S- 0 0 52 -2,-0.4 278,-0.0 1,-0.3 0, 0.0 -0.479 121.2 -17.1 62.4-116.3 39.7 51.0 7.8 10 24 A T T 3 S+ 0 0 48 -2,-0.4 280,-0.3 278,-0.2 2,-0.3 0.200 123.6 87.3-106.2 15.3 36.2 49.7 8.6 11 25 A N E < -A 8 0A 65 -3,-2.2 -3,-2.7 278,-0.1 2,-0.4 -0.846 67.2-137.1-111.2 149.2 34.8 50.4 5.0 12 26 A L E -AB 7 19A 0 7,-0.5 7,-2.4 -2,-0.3 2,-0.3 -0.849 24.4-167.8 -98.9 139.5 34.8 48.2 1.8 13 27 A N E -AB 6 18A 24 -7,-3.0 -7,-2.7 -2,-0.4 2,-0.4 -0.922 15.7-158.6-125.5 153.0 35.7 49.9 -1.5 14 28 A Y E > S-AB 5 17A 12 3,-2.7 3,-1.8 -2,-0.3 -9,-0.2 -0.991 86.6 -13.5-129.7 124.4 35.4 49.0 -5.2 15 29 A N T 3 S- 0 0 105 -11,-1.8 -11,-0.1 -2,-0.4 -10,-0.1 0.854 132.7 -54.6 48.4 36.1 37.6 50.8 -7.7 16 30 A G T 3 S+ 0 0 61 -12,-0.5 2,-0.4 1,-0.2 -1,-0.3 0.504 115.2 114.1 80.7 8.5 38.2 53.3 -4.9 17 31 A H E < S-B 14 0A 102 -3,-1.8 -3,-2.7 331,-0.0 -1,-0.2 -0.909 74.9-102.8-112.8 141.8 34.5 54.0 -4.1 18 32 A H E +B 13 0A 64 -2,-0.4 330,-2.8 -5,-0.2 2,-0.3 -0.368 49.2 176.3 -61.1 126.9 32.7 53.1 -0.9 19 33 A I E -Bc 12 348A 2 -7,-2.4 -7,-0.5 328,-0.3 2,-0.4 -0.861 25.0-144.0-128.6 166.3 30.4 50.0 -1.5 20 34 A F - 0 0 1 328,-1.8 2,-0.6 -2,-0.3 299,-0.2 -0.999 20.3-130.1-130.9 132.2 28.1 47.8 0.5 21 35 A L E +d 319 0B 0 297,-2.5 299,-2.4 -2,-0.4 2,-0.4 -0.753 32.0 175.6 -85.0 117.1 27.8 44.0 -0.1 22 36 A S E +d 320 0B 0 -2,-0.6 38,-2.9 297,-0.2 39,-1.0 -0.981 28.6 74.4-125.1 127.6 24.1 43.0 -0.4 23 37 A G E -de 321 61B 0 297,-2.2 299,-2.0 -2,-0.4 2,-0.3 -0.892 60.4 -72.6 173.6-142.3 22.9 39.5 -1.3 24 38 A A E -de 322 62B 2 37,-1.4 39,-1.7 297,-0.3 2,-0.4 -0.965 27.9-107.2-150.1 157.4 22.4 36.0 -0.2 25 39 A N E - e 0 63B 1 297,-2.6 300,-2.6 -2,-0.3 299,-0.4 -0.750 25.2-179.5 -78.8 135.2 23.9 32.6 0.6 26 40 A Q - 0 0 1 37,-3.2 300,-1.1 -2,-0.4 -1,-0.2 0.973 16.3-178.0 -63.2 -52.3 23.3 30.0 -2.1 27 41 A A - 0 0 0 36,-0.4 38,-3.0 298,-0.2 2,-0.3 -0.898 45.2 -28.8 -86.5 -5.9 24.8 28.2 -0.1 28 42 A W - 0 0 49 36,-0.2 3,-0.1 -2,-0.2 298,-0.1 -0.961 30.1-157.2-154.9 169.3 24.7 25.1 -2.4 29 43 A V S S+ 0 0 48 -2,-0.3 2,-0.7 1,-0.2 -1,-0.1 0.585 102.6 17.0-112.4 -64.2 22.7 23.3 -5.1 30 44 A N S > S- 0 0 97 9,-0.1 3,-2.6 3,-0.0 -1,-0.2 -0.923 104.9-113.4-107.2 105.5 24.0 19.8 -4.5 31 45 A Y T 3 S- 0 0 59 -2,-0.7 -3,-0.1 1,-0.3 35,-0.1 -0.081 89.4 -12.4 -48.1 118.2 25.6 20.0 -1.0 32 46 A A T 3 S+ 0 0 2 33,-0.2 40,-0.5 1,-0.1 -1,-0.3 0.442 126.9 78.4 70.8 5.4 29.4 19.5 -1.2 33 47 A R < + 0 0 111 -3,-2.6 -2,-0.1 39,-0.1 -1,-0.1 -0.267 55.7 103.8-138.5 45.8 29.1 18.3 -4.9 34 48 A D S S+ 0 0 7 32,-0.3 2,-0.3 31,-0.2 9,-0.2 0.664 77.8 39.1-103.3 -22.6 28.7 21.5 -6.9 35 49 A F S S+ 0 0 6 31,-0.2 54,-0.2 4,-0.1 -1,-0.2 -0.982 96.7 28.3-135.7 145.6 32.2 22.0 -8.5 36 50 A G S > S+ 0 0 0 52,-0.6 3,-1.6 -2,-0.3 51,-0.1 0.032 92.0 59.5 85.2 159.5 34.7 19.6 -9.9 37 51 A H T 3 S- 0 0 81 1,-0.3 52,-0.0 2,-0.1 36,-0.0 0.845 131.9 -67.6 53.5 36.9 34.0 16.2 -11.6 38 52 A N T 3 S+ 0 0 92 1,-0.1 4,-0.4 3,-0.0 -1,-0.3 0.781 102.0 134.6 56.2 31.8 31.9 18.0 -14.2 39 53 A Q <> + 0 0 29 -3,-1.6 4,-1.1 1,-0.2 3,-0.4 0.725 53.9 67.6 -85.0 -23.6 29.4 18.8 -11.4 40 54 A Y H >> S+ 0 0 11 1,-0.2 4,-1.7 2,-0.2 3,-0.8 0.929 94.0 58.1 -63.7 -42.2 28.8 22.5 -12.3 41 55 A S H 34 S+ 0 0 73 1,-0.3 4,-0.3 2,-0.2 -1,-0.2 0.822 103.1 56.0 -56.2 -32.3 27.1 21.6 -15.6 42 56 A K H 34 S+ 0 0 153 -4,-0.4 -1,-0.3 -3,-0.4 -2,-0.2 0.851 119.1 29.0 -68.6 -35.5 24.6 19.6 -13.5 43 57 A G H XX S+ 0 0 6 -4,-1.1 4,-2.3 -3,-0.8 3,-0.9 0.431 89.0 106.9-105.0 -2.2 23.6 22.6 -11.3 44 58 A K H 3X S+ 0 0 108 -4,-1.7 4,-2.7 1,-0.3 5,-0.2 0.822 74.8 56.0 -48.9 -43.2 24.2 25.4 -13.8 45 59 A S H 3> S+ 0 0 89 -4,-0.3 4,-2.1 2,-0.2 -1,-0.3 0.895 111.8 42.8 -62.6 -37.3 20.6 26.2 -14.4 46 60 A T H <> S+ 0 0 55 -3,-0.9 4,-2.1 2,-0.2 -2,-0.2 0.906 114.4 49.9 -72.3 -45.5 19.9 26.8 -10.7 47 61 A F H X S+ 0 0 0 -4,-2.3 4,-1.9 1,-0.2 -2,-0.2 0.936 114.6 45.8 -57.4 -43.7 23.0 28.8 -10.2 48 62 A E H X S+ 0 0 61 -4,-2.7 4,-2.2 -5,-0.2 -2,-0.2 0.881 110.7 50.6 -71.1 -39.2 22.2 30.9 -13.3 49 63 A S H X S+ 0 0 50 -4,-2.1 4,-2.5 -5,-0.2 -1,-0.2 0.877 109.2 52.9 -67.2 -34.8 18.5 31.5 -12.3 50 64 A T H X S+ 0 0 1 -4,-2.1 4,-2.3 2,-0.2 -2,-0.2 0.916 109.6 48.6 -63.8 -44.7 19.6 32.6 -8.8 51 65 A L H X S+ 0 0 0 -4,-1.9 4,-2.5 2,-0.2 -2,-0.2 0.890 111.4 49.7 -59.9 -42.7 22.0 35.2 -10.4 52 66 A S H X S+ 0 0 55 -4,-2.2 4,-2.1 2,-0.2 -2,-0.2 0.933 111.3 48.7 -62.4 -49.4 19.3 36.5 -12.7 53 67 A D H X S+ 0 0 49 -4,-2.5 4,-1.1 1,-0.2 -2,-0.2 0.908 113.6 47.6 -54.1 -48.2 16.8 36.9 -9.8 54 68 A M H ><>S+ 0 0 0 -4,-2.3 5,-2.3 2,-0.2 3,-0.6 0.927 108.8 51.8 -66.8 -45.1 19.4 38.7 -7.8 55 69 A Q H ><5S+ 0 0 80 -4,-2.5 3,-1.3 1,-0.3 -1,-0.2 0.921 109.4 50.8 -57.0 -44.9 20.6 41.1 -10.5 56 70 A S H 3<5S+ 0 0 65 -4,-2.1 -1,-0.3 1,-0.2 -2,-0.2 0.761 113.3 46.1 -67.4 -23.9 17.0 42.1 -11.1 57 71 A H T <<5S- 0 0 46 -4,-1.1 -1,-0.2 -3,-0.6 284,-0.2 0.205 121.0-102.1-101.5 12.3 16.4 42.8 -7.4 58 72 A G T < 5 + 0 0 1 -3,-1.3 -3,-0.2 -4,-0.3 2,-0.2 0.596 69.2 146.5 83.3 12.0 19.6 44.8 -6.8 59 73 A G < - 0 0 3 -5,-2.3 -1,-0.3 -6,-0.2 -36,-0.2 -0.527 24.7-175.2 -77.2 150.9 21.8 42.1 -5.1 60 74 A N + 0 0 4 -38,-2.9 46,-2.7 1,-0.2 2,-0.3 0.321 57.5 42.8-130.0 3.7 25.5 42.2 -5.9 61 75 A S E -ef 23 106B 0 -39,-1.0 -37,-1.4 44,-0.3 2,-0.4 -0.995 50.1-163.7-158.1 150.1 27.0 39.2 -4.1 62 76 A V E -ef 24 107B 0 44,-2.3 46,-2.7 -2,-0.3 2,-0.5 -0.995 12.7-147.6-134.1 135.6 26.6 35.5 -3.4 63 77 A R E -ef 25 108B 0 -39,-1.7 -37,-3.2 -2,-0.4 -36,-0.4 -0.915 23.4-178.8-100.5 128.2 28.2 33.2 -0.8 64 78 A V E - f 0 109B 0 44,-2.7 46,-3.0 -2,-0.5 2,-0.4 -0.979 23.5-127.3-131.6 140.3 28.7 29.6 -2.0 65 79 A W E + f 0 110B 13 -38,-3.0 -33,-0.2 -2,-0.4 -31,-0.2 -0.727 26.6 176.9 -92.3 137.0 30.2 26.6 -0.1 66 80 A L E + 0 0 5 44,-3.1 -32,-0.3 -2,-0.4 -31,-0.2 0.823 67.7 4.1-106.0 -85.2 32.9 24.6 -1.8 67 81 A H E >> + 0 0 0 44,-0.8 3,-1.3 43,-0.2 2,-1.3 0.886 69.7 175.3 -77.4 -40.6 34.7 21.6 -0.0 68 82 A I E 34 S- f 0 112B 1 43,-1.8 45,-2.2 42,-0.3 -1,-0.2 -0.535 80.6 -13.9 71.0 -87.3 32.6 21.5 3.2 69 83 A E T 34 S- 0 0 0 -2,-1.3 55,-0.5 43,-0.2 54,-0.3 0.085 106.4 -90.8-128.0 19.5 34.1 18.4 4.8 70 84 A G T <4 S+ 0 0 1 -3,-1.3 -2,-0.2 3,-0.2 6,-0.1 0.722 74.7 147.1 80.1 26.3 35.9 17.0 1.8 71 85 A E S < S- 0 0 28 -4,-0.8 -3,-0.1 1,-0.1 -38,-0.1 0.872 86.6 -5.2 -57.4 -45.1 33.2 14.8 0.4 72 86 A S S S+ 0 0 14 -40,-0.5 -1,-0.1 1,-0.4 -39,-0.1 0.600 118.7 78.5-125.9 -26.3 34.1 15.3 -3.4 73 87 A T S S+ 0 0 1 -6,-0.3 -1,-0.4 -41,-0.3 -3,-0.2 -0.976 75.9 26.1-142.2 150.3 37.0 17.9 -3.4 74 88 A P S S- 0 0 3 0, 0.0 2,-0.5 0, 0.0 11,-0.2 0.682 86.4-107.9 -74.6-167.9 39.9 18.2 -2.9 75 89 A E E -L 84 0C 64 9,-2.4 8,-2.3 -2,-0.1 9,-0.9 -0.759 36.7-164.5 -89.2 127.9 41.6 14.8 -3.5 76 90 A F E -L 82 0C 39 -2,-0.5 6,-0.2 6,-0.3 2,-0.1 -0.860 12.0-135.8-110.6 144.7 42.8 13.0 -0.4 77 91 A D > - 0 0 59 4,-3.1 3,-1.7 -2,-0.3 -1,-0.0 -0.330 43.2 -89.2 -84.2 177.5 45.2 10.0 -0.0 78 92 A N T 3 S+ 0 0 174 1,-0.3 -1,-0.1 2,-0.1 -2,-0.0 0.708 126.3 50.9 -63.9 -19.8 44.5 7.1 2.3 79 93 A N T 3 S- 0 0 117 2,-0.1 -1,-0.3 47,-0.0 -3,-0.0 0.384 122.8 -98.4 -98.1 1.7 46.2 8.8 5.3 80 94 A G S < S+ 0 0 10 -3,-1.7 2,-0.2 1,-0.3 -2,-0.1 0.523 78.8 134.2 93.7 5.9 44.3 12.1 5.0 81 95 A Y - 0 0 62 55,-0.1 -4,-3.1 54,-0.0 2,-0.5 -0.618 58.1-117.6 -80.8 151.9 46.9 14.1 3.1 82 96 A V E -L 76 0C 4 51,-0.4 -6,-0.3 -6,-0.2 58,-0.1 -0.782 28.9-179.2 -92.7 128.7 45.7 16.2 0.1 83 97 A T E - 0 0 83 -8,-2.3 2,-0.3 -2,-0.5 -7,-0.1 0.633 53.5 -67.0-100.6 -21.4 47.3 15.1 -3.3 84 98 A G E -L 75 0C 15 -9,-0.9 -9,-2.4 2,-0.0 2,-0.3 -0.984 52.8 -75.1 164.4-162.3 45.7 17.6 -5.7 85 99 A I - 0 0 42 -2,-0.3 -12,-0.1 -11,-0.2 -49,-0.0 -0.944 46.5 -97.6-131.1 152.8 42.5 18.7 -7.3 86 100 A D > - 0 0 17 -2,-0.3 3,-1.6 1,-0.1 4,-0.5 -0.305 39.3-107.6 -73.4 158.0 40.4 17.1 -10.1 87 101 A N T 3 S+ 0 0 153 1,-0.3 4,-0.2 2,-0.1 -1,-0.1 0.465 113.7 44.7 -75.0 -2.1 40.8 18.4 -13.6 88 102 A T T 3> S+ 0 0 17 2,-0.1 4,-2.4 3,-0.1 -52,-0.6 0.356 85.6 92.1-115.5 5.6 37.5 20.2 -13.9 89 103 A L H <> S+ 0 0 0 -3,-1.6 4,-2.3 2,-0.2 -53,-0.2 0.971 93.7 38.3 -60.8 -55.2 37.4 22.0 -10.5 90 104 A I H > S+ 0 0 40 -4,-0.5 4,-2.7 2,-0.2 -1,-0.2 0.926 117.5 49.7 -64.2 -43.3 39.1 25.2 -11.7 91 105 A S H > S+ 0 0 66 1,-0.2 4,-2.0 2,-0.2 -1,-0.2 0.870 111.4 50.2 -66.6 -35.1 37.2 25.2 -15.0 92 106 A D H X S+ 0 0 15 -4,-2.4 4,-1.9 2,-0.2 -1,-0.2 0.918 112.4 46.7 -62.8 -47.5 33.9 24.7 -13.2 93 107 A M H X S+ 0 0 0 -4,-2.3 4,-2.4 -5,-0.2 -2,-0.2 0.910 112.7 50.5 -62.6 -40.3 34.6 27.5 -10.8 94 108 A R H X S+ 0 0 79 -4,-2.7 4,-2.2 2,-0.2 -2,-0.2 0.876 107.0 53.4 -66.1 -38.0 35.7 29.8 -13.8 95 109 A A H X S+ 0 0 40 -4,-2.0 4,-1.9 2,-0.2 -1,-0.2 0.906 111.1 46.9 -63.9 -42.4 32.4 29.0 -15.7 96 110 A Y H X S+ 0 0 0 -4,-1.9 4,-2.5 2,-0.2 -2,-0.2 0.915 110.6 51.9 -63.4 -45.5 30.4 30.1 -12.7 97 111 A L H X S+ 0 0 0 -4,-2.4 4,-2.3 1,-0.2 -2,-0.2 0.875 108.1 51.9 -59.8 -36.8 32.5 33.2 -12.3 98 112 A H H X S+ 0 0 74 -4,-2.2 4,-1.6 2,-0.2 -1,-0.2 0.899 110.2 49.1 -67.1 -40.3 31.9 34.1 -16.0 99 113 A A H X S+ 0 0 3 -4,-1.9 4,-0.7 2,-0.2 -2,-0.2 0.912 111.4 49.2 -61.5 -43.5 28.1 33.7 -15.5 100 114 A A H ><>S+ 0 0 0 -4,-2.5 5,-2.0 1,-0.2 3,-1.2 0.916 107.6 55.1 -62.7 -41.6 28.3 35.9 -12.4 101 115 A Q H ><5S+ 0 0 63 -4,-2.3 3,-1.6 1,-0.3 -1,-0.2 0.883 100.8 58.2 -59.6 -39.9 30.3 38.6 -14.3 102 116 A R H 3<5S+ 0 0 172 -4,-1.6 -1,-0.3 1,-0.3 -2,-0.2 0.725 113.5 40.4 -63.4 -22.6 27.5 38.7 -17.0 103 117 A H T <<5S- 0 0 25 -3,-1.2 -1,-0.3 -4,-0.7 -2,-0.2 0.178 113.9-115.5-107.7 11.6 25.1 39.7 -14.1 104 118 A N T < 5 + 0 0 66 -3,-1.6 2,-0.4 1,-0.2 247,-0.2 0.869 67.3 141.7 51.6 45.8 27.5 42.0 -12.2 105 119 A I < - 0 0 0 -5,-2.0 2,-0.4 -8,-0.1 -44,-0.3 -0.944 45.0-139.6-119.5 135.4 27.6 39.8 -9.1 106 120 A L E -f 61 0B 1 -46,-2.7 -44,-2.3 -2,-0.4 2,-0.4 -0.793 17.4-144.2 -90.6 137.2 30.6 39.0 -6.9 107 121 A I E -fg 62 155B 0 47,-3.1 49,-2.6 -2,-0.4 50,-1.5 -0.838 9.8-164.7-106.0 135.2 31.2 35.5 -5.6 108 122 A F E -fg 63 157B 2 -46,-2.7 -44,-2.7 -2,-0.4 2,-0.5 -0.973 13.1-152.6-115.0 117.1 32.5 34.5 -2.2 109 123 A F E -fg 64 158B 0 48,-2.1 50,-2.7 -2,-0.5 2,-0.6 -0.773 1.9-151.7 -92.2 128.3 33.6 30.8 -1.9 110 124 A T E -fg 65 159B 1 -46,-3.0 -44,-3.1 -2,-0.5 -42,-0.3 -0.882 6.6-164.8-100.5 120.7 33.5 29.2 1.6 111 125 A L E + 0 0 0 48,-2.7 -43,-1.8 -2,-0.6 -44,-0.8 0.971 60.6 13.5 -72.8 -56.5 36.1 26.4 1.9 112 126 A W E -fg 68 161B 2 48,-1.3 50,-2.4 47,-0.3 2,-0.4 -0.714 59.7-138.3-122.7 165.7 35.1 24.4 5.0 113 127 A N E + g 0 162B 3 -45,-2.2 50,-0.2 48,-0.2 3,-0.1 -0.986 17.4 173.6-131.4 128.1 32.2 23.8 7.4 114 128 A G + 0 0 0 48,-3.2 78,-0.2 -2,-0.4 49,-0.1 0.286 65.0 86.2-107.6 7.4 32.3 23.4 11.2 115 129 A A S S+ 0 0 23 47,-0.3 2,-0.3 1,-0.1 -1,-0.1 0.626 94.3 29.6 -88.0 -15.2 28.6 23.5 11.9 116 130 A V - 0 0 51 -3,-0.1 2,-0.6 76,-0.0 -1,-0.1 -0.992 64.6-146.3-146.3 146.1 27.9 19.8 11.4 117 131 A K + 0 0 113 -2,-0.3 2,-0.1 49,-0.1 -3,-0.1 -0.962 33.3 161.2-117.6 108.6 30.0 16.6 11.8 118 132 A Q > - 0 0 101 -2,-0.6 3,-1.8 -49,-0.0 4,-0.2 -0.371 53.8 -65.5-118.1-164.1 29.1 13.9 9.2 119 133 A S T 3 S+ 0 0 112 1,-0.3 3,-0.3 -2,-0.1 -2,-0.0 0.643 127.6 45.4 -70.8 -19.0 30.7 10.7 7.8 120 134 A T T >> S+ 0 0 16 1,-0.2 3,-2.0 2,-0.1 4,-0.8 0.207 76.3 114.2-103.2 17.1 33.7 12.3 6.0 121 135 A H H <> + 0 0 7 -3,-1.8 4,-3.0 1,-0.3 5,-0.2 0.808 63.1 71.6 -56.5 -32.9 34.6 14.6 9.0 122 136 A Y H 3> S+ 0 0 140 -3,-0.3 4,-1.9 1,-0.2 -1,-0.3 0.793 91.8 59.0 -52.7 -30.8 37.9 12.7 9.5 123 137 A R H <> S+ 0 0 65 -3,-2.0 4,-1.1 -54,-0.3 -1,-0.2 0.960 112.2 37.1 -65.0 -52.3 39.2 14.3 6.3 124 138 A L H X S+ 0 0 0 -4,-0.8 4,-1.7 -55,-0.5 3,-0.4 0.899 111.6 62.1 -64.3 -40.1 38.7 17.8 7.7 125 139 A N H X S+ 0 0 56 -4,-3.0 4,-2.2 1,-0.2 5,-0.3 0.890 99.9 53.8 -52.4 -45.7 39.8 16.7 11.2 126 140 A G H X S+ 0 0 4 -4,-1.9 4,-2.1 1,-0.2 8,-0.4 0.878 107.7 49.6 -57.2 -42.2 43.2 15.7 9.9 127 141 A L H < S+ 0 0 1 -4,-1.1 -1,-0.2 -3,-0.4 -2,-0.2 0.814 112.4 49.8 -68.9 -30.3 43.8 19.2 8.4 128 142 A M H < S+ 0 0 3 -4,-1.7 -2,-0.2 1,-0.1 -1,-0.2 0.876 122.5 27.3 -74.6 -38.8 42.7 20.8 11.8 129 143 A V H < S+ 0 0 64 -4,-2.2 2,-0.6 1,-0.2 -2,-0.2 0.653 113.6 61.8-104.8 -15.9 44.9 18.7 14.1 130 144 A D >X - 0 0 29 -4,-2.1 4,-2.4 -5,-0.3 3,-0.6 -0.934 60.4-162.4-116.9 107.0 48.0 17.7 11.9 131 145 A T H 3> S+ 0 0 46 -2,-0.6 4,-2.3 1,-0.2 -1,-0.1 0.813 90.7 56.7 -62.0 -27.7 50.0 20.7 10.6 132 146 A R H 3> S+ 0 0 146 2,-0.2 4,-1.3 1,-0.2 -1,-0.2 0.861 108.0 47.6 -72.3 -32.2 51.7 18.5 7.9 133 147 A K H <> S+ 0 0 44 -3,-0.6 4,-1.7 -7,-0.3 -51,-0.4 0.932 110.4 52.4 -69.0 -45.8 48.3 17.5 6.5 134 148 A L H X S+ 0 0 1 -4,-2.4 4,-2.0 -8,-0.4 3,-0.2 0.924 107.0 53.4 -54.6 -44.7 47.2 21.2 6.6 135 149 A Q H X S+ 0 0 62 -4,-2.3 4,-2.7 1,-0.2 -1,-0.2 0.872 103.4 56.4 -61.2 -34.8 50.3 22.1 4.6 136 150 A S H X S+ 0 0 11 -4,-1.3 4,-2.3 -3,-0.3 5,-0.3 0.889 107.2 49.5 -64.2 -38.0 49.5 19.5 1.9 137 151 A Y H X>S+ 0 0 0 -4,-1.7 5,-2.5 -3,-0.2 4,-1.8 0.920 112.0 48.5 -63.0 -44.1 46.1 21.1 1.4 138 152 A I H <>S+ 0 0 6 -4,-2.0 5,-2.3 3,-0.2 -2,-0.2 0.936 118.0 39.1 -61.5 -47.2 47.8 24.5 1.1 139 153 A D H <5S+ 0 0 76 -4,-2.7 -2,-0.2 1,-0.2 -1,-0.2 0.872 125.2 33.2 -74.4 -39.2 50.4 23.4 -1.4 140 154 A H H <5S+ 0 0 95 -4,-2.3 -1,-0.2 -5,-0.2 -2,-0.2 0.596 134.8 7.9-100.0 -13.6 48.3 21.0 -3.6 141 155 A A T X5S+ 0 0 0 -4,-1.8 4,-2.0 -5,-0.3 -3,-0.2 0.624 120.4 48.5-132.4 -56.1 44.9 22.6 -3.6 142 156 A L H > S+ 0 0 49 0, 0.0 4,-2.0 0, 0.0 -1,-0.2 0.905 114.6 46.3 -52.6 -42.4 46.7 26.4 -7.2 145 159 A M H X S+ 0 0 0 -4,-2.0 4,-1.7 2,-0.2 -2,-0.2 0.942 114.3 44.9 -67.4 -49.5 43.0 27.4 -6.9 146 160 A A H X S+ 0 0 0 -4,-2.6 4,-0.8 1,-0.2 -1,-0.2 0.876 115.2 48.8 -66.4 -37.0 43.6 31.0 -5.6 147 161 A N H < S+ 0 0 78 -4,-2.7 3,-0.4 -5,-0.3 4,-0.2 0.915 111.0 49.5 -68.9 -40.3 46.4 31.6 -8.2 148 162 A A H < S+ 0 0 32 -4,-2.0 3,-0.3 -5,-0.3 -1,-0.2 0.825 117.9 38.3 -67.8 -34.7 44.3 30.4 -11.1 149 163 A L H >< S+ 0 0 0 -4,-1.7 3,-2.0 1,-0.2 -1,-0.2 0.470 83.5 100.6 -98.7 -3.1 41.2 32.5 -10.3 150 164 A K T 3< S+ 0 0 58 -4,-0.8 -1,-0.2 -3,-0.4 -2,-0.1 0.698 80.9 52.2 -63.5 -21.4 42.7 35.8 -9.0 151 165 A N T 3 S+ 0 0 134 -3,-0.3 2,-0.5 -4,-0.2 -1,-0.3 0.374 79.6 113.7 -96.2 5.7 42.1 37.7 -12.3 152 166 A E X - 0 0 20 -3,-2.0 3,-1.6 1,-0.1 -3,-0.0 -0.672 61.7-147.3 -78.6 123.5 38.4 36.8 -12.6 153 167 A K T 3 S+ 0 0 74 -2,-0.5 -1,-0.1 1,-0.3 -55,-0.1 0.767 94.6 55.9 -65.2 -26.5 36.5 40.0 -12.1 154 168 A A T 3 S+ 0 0 0 -48,-0.1 -47,-3.1 -57,-0.1 2,-0.8 0.477 78.1 108.8 -85.1 -1.1 33.6 38.2 -10.4 155 169 A L E < +g 107 0B 13 -3,-1.6 -47,-0.2 -49,-0.2 3,-0.1 -0.663 39.3 174.6 -79.3 108.9 35.7 36.7 -7.7 156 170 A G E - 0 0 6 -49,-2.6 64,-0.4 -2,-0.8 2,-0.3 0.903 48.4 -87.7 -75.5 -48.2 34.9 38.6 -4.4 157 171 A G E -g 108 0B 2 -50,-1.5 -48,-2.1 62,-0.1 2,-0.4 -0.994 39.8 -65.9 164.5-164.1 36.9 36.5 -2.0 158 172 A W E -gh 109 221B 1 62,-2.4 64,-2.3 -2,-0.3 2,-0.6 -0.976 17.8-160.6-130.1 131.3 37.4 33.5 0.3 159 173 A D E -gh 110 222B 2 -50,-2.7 -48,-2.7 -2,-0.4 -47,-0.3 -0.963 13.6-155.5-108.4 117.9 35.7 32.5 3.6 160 174 A I E - 0 0 0 62,-2.7 -48,-1.3 -2,-0.6 2,-0.3 0.879 68.2 -3.7 -64.4 -40.7 38.0 29.9 5.3 161 175 A M E -g 112 0B 1 61,-0.3 63,-1.7 -50,-0.2 2,-0.6 -0.972 59.2-126.6-157.8 138.1 35.3 28.2 7.4 162 176 A N E S-gh 113 224B 2 -50,-2.4 -48,-3.2 -2,-0.3 -47,-0.3 -0.791 88.3 -22.3 -81.6 122.6 31.7 28.4 8.3 163 177 A E > - 0 0 20 61,-3.1 3,-2.0 -2,-0.6 4,-0.2 0.878 60.6-177.5 46.7 64.5 31.1 28.5 12.1 164 178 A P G > S+ 0 0 3 0, 0.0 3,-1.9 0, 0.0 4,-0.2 0.787 76.4 75.0 -56.8 -25.0 34.3 27.0 13.6 165 179 A E G > S+ 0 0 0 1,-0.3 25,-2.5 2,-0.2 3,-0.6 0.612 74.2 81.1 -67.4 -11.2 32.7 27.4 17.0 166 180 A G G < S+ 0 0 0 -3,-2.0 26,-2.5 1,-0.2 27,-0.7 0.777 106.2 28.9 -56.3 -27.5 30.5 24.4 16.2 167 181 A E G < S+ 0 0 1 -3,-1.9 29,-2.7 -4,-0.2 28,-1.2 0.228 94.3 120.2-125.2 13.9 33.4 22.3 17.2 168 182 A I B < -m 196 0D 0 -3,-0.6 29,-0.2 27,-0.2 25,-0.2 -0.360 65.8-116.6 -79.5 155.6 35.3 24.4 19.8 169 183 A K - 0 0 75 27,-1.8 3,-0.5 25,-0.2 29,-0.2 -0.851 36.0-157.6 -90.2 105.7 35.9 23.4 23.4 170 184 A P + 0 0 29 0, 0.0 12,-0.2 0, 0.0 11,-0.0 -0.386 64.3 37.5 -79.6 163.1 34.0 25.8 25.7 171 185 A G S S+ 0 0 34 10,-2.4 2,-0.4 1,-0.2 11,-0.3 0.603 77.2 144.7 80.2 13.5 34.8 26.6 29.4 172 186 A E - 0 0 91 -3,-0.5 9,-2.7 7,-0.1 10,-0.6 -0.719 41.3-140.7 -93.3 130.8 38.5 26.4 29.1 173 187 A S - 0 0 94 -2,-0.4 2,-0.3 7,-0.2 3,-0.1 -0.553 23.8-179.4 -79.4 151.0 40.8 28.7 31.1 174 188 A S - 0 0 47 -2,-0.2 6,-0.1 1,-0.1 8,-0.1 -0.989 39.4-138.4-150.1 148.4 44.0 30.2 29.5 175 189 A S S S+ 0 0 133 -2,-0.3 -1,-0.1 1,-0.1 3,-0.1 0.709 100.9 69.5 -71.7 -24.9 46.9 32.4 30.5 176 190 A E S > S- 0 0 42 1,-0.1 3,-1.5 -3,-0.1 4,-0.5 -0.892 83.4-148.3 -91.7 113.4 46.4 34.0 27.0 177 191 A P G > S+ 0 0 73 0, 0.0 3,-1.3 0, 0.0 -1,-0.1 0.835 92.3 57.5 -52.2 -40.1 43.0 35.9 27.3 178 192 A C G 3 S+ 0 0 9 1,-0.3 60,-0.1 -3,-0.1 64,-0.1 0.685 106.5 49.8 -71.6 -16.6 42.0 35.4 23.6 179 193 A F G < S+ 0 0 32 -3,-1.5 19,-0.4 19,-0.0 2,-0.3 0.468 85.8 107.4 -93.1 -4.2 42.3 31.6 24.0 180 194 A D < - 0 0 9 -3,-1.3 -7,-0.2 -4,-0.5 3,-0.2 -0.606 43.9-178.9 -76.6 128.1 40.1 31.6 27.1 181 195 A T > + 0 0 1 -9,-2.7 -10,-2.4 -2,-0.3 3,-1.6 0.136 47.5 111.4-117.0 21.4 36.6 30.2 26.4 182 196 A R G > S+ 0 0 144 -10,-0.6 3,-1.3 1,-0.3 -1,-0.1 0.854 75.7 61.1 -62.0 -32.8 35.0 30.5 29.8 183 197 A H G 3 S+ 0 0 36 1,-0.3 -1,-0.3 -3,-0.2 -2,-0.1 0.623 96.7 59.9 -68.8 -15.3 32.7 33.1 28.4 184 198 A L G X S+ 0 0 2 -3,-1.6 3,-2.0 -12,-0.1 5,-0.5 0.502 76.1 115.3 -90.4 -8.4 31.3 30.6 25.9 185 199 A S T < S+ 0 0 74 -3,-1.3 -3,-0.0 -4,-0.4 -14,-0.0 -0.455 86.6 13.7 -58.5 129.2 30.1 28.3 28.7 186 200 A G T 3 S+ 0 0 90 -2,-0.2 -1,-0.3 3,-0.1 -2,-0.1 0.422 102.3 102.9 81.7 -1.0 26.3 28.2 28.4 187 201 A S S < S- 0 0 28 -3,-2.0 -2,-0.1 2,-0.1 3,-0.1 0.605 93.2-113.2 -87.3 -16.9 26.3 29.8 24.9 188 202 A G > + 0 0 48 -4,-0.4 3,-0.6 1,-0.3 -3,-0.1 0.200 65.7 147.1 96.6 -14.9 25.7 26.6 22.9 189 203 A A T 3 + 0 0 7 -5,-0.5 -1,-0.3 1,-0.2 -23,-0.2 -0.183 58.4 38.8 -51.8 148.2 29.2 26.6 21.4 190 204 A G T > + 0 0 5 -25,-2.5 3,-1.2 -21,-0.1 -1,-0.2 0.647 69.9 145.3 80.5 20.8 30.6 23.1 20.7 191 205 A W T < S+ 0 0 110 -3,-0.6 -24,-0.1 1,-0.3 3,-0.1 0.756 72.5 46.3 -61.3 -29.0 27.2 21.7 19.6 192 206 A A T 3 S- 0 0 23 -26,-2.5 -1,-0.3 1,-0.4 -25,-0.2 0.542 135.3 -49.6 -90.4 -8.5 28.8 19.4 16.9 193 207 A G < - 0 0 21 -3,-1.2 2,-1.5 -27,-0.7 -1,-0.4 -0.515 46.3-103.4 147.6 147.4 31.4 18.2 19.4 194 208 A H S S+ 0 0 120 1,-0.2 -25,-0.2 -2,-0.2 -26,-0.2 -0.611 73.8 132.3 -89.0 75.2 34.0 19.5 21.9 195 209 A L + 0 0 53 -2,-1.5 2,-0.4 -28,-1.2 -27,-0.2 0.862 48.6 39.9-100.0 -44.3 36.8 18.8 19.4 196 210 A Y B -m 168 0D 4 -29,-2.7 -27,-1.8 -3,-0.3 -1,-0.2 -0.887 66.7-127.1-124.1 140.9 39.2 21.7 19.0 197 211 A S > - 0 0 25 -2,-0.4 4,-2.0 -29,-0.2 5,-0.2 -0.405 33.9-109.2 -74.6 161.1 40.9 24.2 21.2 198 212 A A H > S+ 0 0 6 -19,-0.4 4,-2.3 -29,-0.2 5,-0.2 0.894 121.7 54.5 -55.0 -40.7 40.7 27.9 20.4 199 213 A Q H > S+ 0 0 65 2,-0.2 4,-2.3 1,-0.2 -1,-0.2 0.876 105.2 52.1 -63.3 -37.7 44.4 27.8 19.5 200 214 A E H > S+ 0 0 40 2,-0.2 4,-2.1 1,-0.2 -2,-0.2 0.929 111.2 46.5 -64.4 -43.5 43.8 25.0 17.0 201 215 A I H X S+ 0 0 2 -4,-2.0 4,-2.0 1,-0.2 5,-0.2 0.926 111.4 52.6 -63.3 -44.5 41.0 26.9 15.2 202 216 A G H X S+ 0 0 2 -4,-2.3 4,-2.8 1,-0.2 48,-0.2 0.898 109.1 49.0 -58.7 -43.3 43.2 30.0 15.2 203 217 A R H X S+ 0 0 41 -4,-2.3 4,-2.5 46,-0.3 5,-0.3 0.923 108.2 54.1 -61.4 -44.3 46.1 28.2 13.6 204 218 A F H X S+ 0 0 1 -4,-2.1 4,-1.4 1,-0.2 -2,-0.2 0.921 114.9 40.2 -55.9 -45.1 43.8 26.7 10.9 205 219 A V H X S+ 0 0 0 -4,-2.0 4,-2.5 2,-0.2 5,-0.3 0.943 113.2 53.8 -71.7 -48.6 42.6 30.1 9.9 206 220 A N H X S+ 0 0 0 -4,-2.8 4,-2.1 1,-0.2 -2,-0.2 0.902 110.3 46.9 -53.4 -46.6 46.0 31.9 10.2 207 221 A W H X S+ 0 0 41 -4,-2.5 4,-1.8 1,-0.2 -1,-0.2 0.892 114.4 44.9 -69.0 -38.1 47.7 29.4 7.9 208 222 A Q H X S+ 0 0 0 -4,-1.4 4,-2.1 -5,-0.3 5,-0.2 0.888 111.7 52.6 -75.0 -35.5 45.1 29.4 5.1 209 223 A A H X S+ 0 0 0 -4,-2.5 4,-1.9 1,-0.2 -2,-0.2 0.923 110.8 48.3 -61.6 -43.7 44.8 33.2 5.2 210 224 A A H X S+ 0 0 9 -4,-2.1 4,-1.2 -5,-0.3 -2,-0.2 0.902 109.8 52.8 -64.2 -39.5 48.5 33.5 4.8 211 225 A A H X S+ 0 0 3 -4,-1.8 4,-1.2 2,-0.2 3,-0.4 0.917 109.2 47.3 -62.5 -45.6 48.5 31.0 1.9 212 226 A I H X S+ 0 0 0 -4,-2.1 4,-2.3 1,-0.2 3,-0.5 0.927 112.7 49.6 -63.4 -42.4 45.8 32.8 -0.1 213 227 A K H < S+ 0 0 45 -4,-1.9 -1,-0.2 1,-0.2 -2,-0.2 0.667 102.0 63.5 -76.0 -15.6 47.6 36.2 0.4 214 228 A E H < S+ 0 0 132 -4,-1.2 -1,-0.2 -3,-0.4 -2,-0.2 0.876 117.8 25.8 -70.2 -39.0 50.9 34.7 -0.8 215 229 A V H < S+ 0 0 26 -4,-1.2 -2,-0.2 -3,-0.5 -3,-0.1 0.665 138.7 28.3 -98.6 -22.0 49.6 33.9 -4.3 216 230 A D >< + 0 0 25 -4,-2.3 3,-2.6 -5,-0.2 -1,-0.2 -0.659 68.3 178.6-137.4 75.9 46.9 36.6 -4.4 217 231 A P T 3 S+ 0 0 99 0, 0.0 -4,-0.1 0, 0.0 -1,-0.1 0.736 80.6 52.5 -55.7 -25.0 48.0 39.5 -2.1 218 232 A G T 3 S+ 0 0 53 2,-0.1 -5,-0.1 -212,-0.0 -214,-0.1 0.355 83.8 127.2 -92.1 5.5 45.0 41.6 -2.8 219 233 A A < - 0 0 8 -3,-2.6 2,-0.5 -7,-0.2 -62,-0.1 -0.283 59.9-127.0 -66.2 145.1 42.5 38.9 -2.0 220 234 A M - 0 0 18 -64,-0.4 -62,-2.4 38,-0.1 2,-0.4 -0.820 31.8-176.7 -89.0 127.5 39.7 39.4 0.5 221 235 A V E +h 158 0B 0 -2,-0.5 37,-2.9 -64,-0.2 38,-1.2 -0.991 9.7 153.7-128.6 137.0 39.7 36.7 3.2 222 236 A T E -h 159 0B 2 -64,-2.3 -62,-2.7 -2,-0.4 2,-0.3 -0.804 31.9-131.0-144.0-177.4 37.2 36.2 6.1 223 237 A V E - 0 0 1 36,-0.3 2,-1.2 -64,-0.2 38,-0.7 -0.971 23.3-127.2-140.2 134.1 35.7 33.5 8.5 224 238 A G E -hi 162 261B 0 -63,-1.7 -61,-3.1 -2,-0.3 38,-0.2 -0.671 29.9-159.0 -85.7 91.5 31.9 33.1 9.2 225 239 A S E - i 0 262B 0 36,-2.3 38,-2.0 -2,-1.2 68,-0.1 -0.441 14.5-139.4 -74.5 139.3 31.6 33.3 13.0 226 240 A W S S+ 0 0 37 36,-0.2 2,-0.3 1,-0.2 -1,-0.1 0.755 78.9 3.9 -70.3 -27.3 28.5 31.7 14.6 227 241 A N > - 0 0 23 37,-0.1 3,-1.9 1,-0.0 -1,-0.2 -0.986 69.1-113.5-161.4 145.5 27.9 34.4 17.2 228 242 A M G > S+ 0 0 1 -2,-0.3 3,-2.1 35,-0.3 4,-0.4 0.714 104.0 80.4 -57.1 -23.9 29.4 37.8 18.3 229 243 A K G 3 S+ 0 0 51 1,-0.3 9,-1.1 2,-0.2 -1,-0.3 0.696 100.3 40.0 -56.2 -19.5 30.6 36.2 21.6 230 244 A A G < S+ 0 0 0 -3,-1.9 10,-2.2 7,-0.1 11,-0.4 0.277 113.9 55.7-106.7 6.0 33.5 34.9 19.7 231 245 A D B < S+N 239 0E 1 -3,-2.1 2,-0.3 8,-0.3 8,-0.3 0.168 97.2 55.5-133.1 17.6 34.1 38.0 17.5 232 246 A T - 0 0 0 6,-0.5 53,-0.1 -4,-0.4 -1,-0.1 -0.991 52.0-153.3-151.3 145.6 34.6 41.0 19.9 233 247 A D S S+ 0 0 99 51,-0.5 3,-0.4 -2,-0.3 2,-0.1 0.395 78.6 88.4 -92.6 -1.2 36.8 42.0 22.8 234 248 A A S > S+ 0 0 20 50,-0.5 3,-1.9 1,-0.2 -2,-0.1 -0.372 76.5 32.7 -84.6 171.0 34.0 44.3 24.1 235 249 A M T 3 S- 0 0 66 1,-0.3 -1,-0.2 48,-0.1 3,-0.1 0.667 131.9 -61.3 60.0 22.4 31.1 43.4 26.5 236 250 A G T 3 S+ 0 0 64 -3,-0.4 -1,-0.3 1,-0.3 2,-0.1 0.619 110.8 111.5 80.6 13.7 33.2 40.8 28.4 237 251 A F < - 0 0 34 -3,-1.9 2,-0.4 -9,-0.1 -1,-0.3 -0.416 60.3-125.1-106.8-178.0 33.8 38.6 25.4 238 252 A H - 0 0 48 -9,-1.1 2,-0.8 -2,-0.1 -6,-0.5 -0.995 12.0-130.2-132.8 142.2 37.0 37.7 23.4 239 253 A N B > -N 231 0E 3 -2,-0.4 3,-0.9 -8,-0.3 -8,-0.3 -0.816 16.3-172.9 -92.3 107.0 37.7 38.0 19.6 240 254 A L T 3 S+ 0 0 4 -10,-2.2 -1,-0.1 -2,-0.8 -9,-0.1 0.630 82.8 52.1 -65.4 -18.7 39.1 34.7 18.3 241 255 A Y T 3 S+ 0 0 0 -11,-0.4 16,-0.4 4,-0.1 -1,-0.2 0.241 75.6 122.7-112.4 12.7 39.9 36.3 14.9 242 256 A S S <> S- 0 0 18 -3,-0.9 4,-2.5 1,-0.1 5,-0.3 -0.312 75.5-110.5 -69.1 158.5 41.8 39.4 15.7 243 257 A D H > S+ 0 0 70 1,-0.2 4,-2.4 2,-0.2 5,-0.3 0.918 119.3 52.6 -53.9 -47.5 45.3 39.8 14.2 244 258 A H H > S+ 0 0 120 1,-0.2 4,-2.0 2,-0.2 -1,-0.2 0.912 111.9 43.9 -56.4 -47.9 46.8 39.4 17.6 245 259 A C H > S+ 0 0 1 -6,-0.2 4,-2.3 2,-0.2 -1,-0.2 0.920 114.8 47.6 -65.5 -46.6 45.0 36.1 18.3 246 260 A L H X S+ 0 0 0 -4,-2.5 4,-2.4 2,-0.2 5,-0.4 0.886 114.1 46.3 -65.2 -39.8 45.5 34.5 14.9 247 261 A V H X S+ 0 0 24 -4,-2.4 4,-1.9 -5,-0.3 -1,-0.2 0.894 112.9 50.0 -72.7 -37.2 49.2 35.3 14.8 248 262 A K H < S+ 0 0 129 -4,-2.0 -2,-0.2 -5,-0.3 -1,-0.2 0.901 115.0 46.5 -62.5 -38.5 49.7 34.1 18.4 249 263 A A H < S+ 0 0 7 -4,-2.3 -46,-0.3 -5,-0.2 -2,-0.2 0.901 132.1 11.7 -70.6 -45.3 47.8 30.9 17.4 250 264 A G H < S- 0 0 17 -4,-2.4 -3,-0.2 -48,-0.2 -2,-0.2 0.560 87.1-130.1-115.4 -18.8 49.6 30.0 14.1 251 265 A G < + 0 0 52 -4,-1.9 2,-0.7 -5,-0.4 -4,-0.1 0.405 62.4 127.9 85.6 -3.8 52.7 32.3 13.8 252 266 A K > - 0 0 90 -6,-0.3 3,-1.6 1,-0.2 -1,-0.2 -0.782 44.6-159.8 -92.5 113.8 52.2 33.6 10.3 253 267 A Q T 3 S+ 0 0 153 -2,-0.7 -1,-0.2 1,-0.3 -6,-0.1 0.809 91.9 48.4 -63.7 -29.4 52.3 37.4 10.3 254 268 A S T 3 S+ 0 0 67 1,-0.2 2,-1.8 -7,-0.1 -1,-0.3 0.478 84.4 100.3 -85.3 -4.3 50.5 37.8 7.0 255 269 A G < + 0 0 0 -3,-1.6 2,-0.3 -12,-0.1 -45,-0.2 -0.391 53.5 123.0 -88.4 61.0 47.7 35.4 8.1 256 270 A T - 0 0 23 -2,-1.8 2,-0.1 -47,-0.2 -35,-0.1 -0.802 61.3-106.7-119.8 156.6 45.1 38.0 9.1 257 271 A L - 0 0 3 -16,-0.4 -35,-0.2 -2,-0.3 3,-0.1 -0.482 9.2-146.6 -82.8 156.4 41.5 38.5 7.9 258 272 A S S S- 0 0 13 -37,-2.9 2,-0.3 1,-0.3 -36,-0.2 0.840 82.2 -4.6 -83.5 -44.7 40.4 41.3 5.6 259 273 A F S S- 0 0 1 -38,-1.2 -36,-0.3 29,-0.2 -1,-0.3 -0.956 71.9-113.4-147.3 163.0 37.0 41.6 7.2 260 274 A Y E - j 0 290B 12 29,-2.8 31,-2.4 -2,-0.3 2,-0.4 -0.646 21.5-162.6 -97.2 154.7 34.9 40.0 9.8 261 275 A Q E -ij 224 291B 0 -38,-0.7 -36,-2.3 -2,-0.2 2,-0.4 -0.989 9.1-177.0-140.3 128.7 31.7 38.1 9.2 262 276 A V E -ij 225 292B 0 29,-2.2 31,-1.5 -2,-0.4 32,-0.7 -0.974 15.0-144.3-131.4 145.2 29.1 37.2 11.9 263 277 A H E - j 0 294B 1 -38,-2.0 2,-0.3 -2,-0.4 -35,-0.3 -0.760 17.0-171.5-104.1 150.7 25.9 35.3 11.9 264 278 A T + 0 0 5 30,-2.0 2,-0.3 -2,-0.3 32,-0.3 -0.947 11.9 165.0-152.3 127.7 22.8 36.2 14.0 265 279 A Y - 0 0 81 -2,-0.3 7,-0.3 30,-0.1 35,-0.2 -0.983 32.6-117.8-135.3 145.0 19.5 34.5 14.7 266 280 A D - 0 0 22 33,-2.0 2,-0.4 -2,-0.3 5,-0.2 -0.178 17.9-141.5 -74.0 172.7 16.9 35.2 17.4 267 281 A W B > S-O 270 0F 193 3,-2.6 3,-1.3 1,-0.1 32,-0.0 -0.972 80.8 -11.0-139.9 125.6 15.9 32.8 20.2 268 282 A Q T 3 S- 0 0 153 -2,-0.4 -1,-0.1 1,-0.2 3,-0.1 0.905 131.6 -54.5 46.5 47.6 12.2 32.5 21.3 269 283 A N T 3 S+ 0 0 99 1,-0.1 2,-0.4 0, 0.0 -1,-0.2 0.622 120.4 96.4 64.8 20.8 11.5 35.7 19.2 270 284 A H B < -O 267 0F 138 -3,-1.3 -3,-2.6 32,-0.0 2,-0.3 -0.999 67.5-131.0-136.2 141.2 14.2 37.9 20.9 271 285 A F - 0 0 27 -2,-0.4 -5,-0.1 -5,-0.2 2,-0.1 -0.691 31.1-118.2 -79.1 141.0 17.8 38.8 19.9 272 286 A G > - 0 0 33 -2,-0.3 3,-2.0 -7,-0.3 6,-0.1 -0.375 31.1-102.4 -70.0 161.2 20.4 38.4 22.7 273 287 A N T 3 S+ 0 0 110 1,-0.3 -1,-0.1 -2,-0.1 5,-0.1 0.692 119.4 63.0 -61.9 -20.5 22.3 41.5 23.8 274 288 A E T 3 S+ 0 0 31 3,-0.0 -1,-0.3 2,-0.0 5,-0.1 0.633 78.1 116.0 -76.7 -14.2 25.3 40.4 21.7 275 289 A S X - 0 0 1 -3,-2.0 3,-2.1 1,-0.1 4,-0.3 -0.291 68.4-135.3 -64.7 137.4 23.5 40.6 18.4 276 290 A P T 3 S+ 0 0 1 0, 0.0 3,-0.5 0, 0.0 -1,-0.1 0.656 105.7 66.4 -61.2 -16.1 24.6 43.1 15.7 277 291 A F T 3 S+ 0 0 8 1,-0.2 -2,-0.1 3,-0.0 3,-0.1 0.479 99.0 51.5 -82.2 0.1 20.9 43.9 15.3 278 292 A K S < S+ 0 0 120 -3,-2.1 2,-0.3 -6,-0.1 -1,-0.2 0.409 116.1 33.0-108.3 -1.8 20.8 45.4 18.8 279 293 A H S S- 0 0 33 -3,-0.5 2,-0.2 -4,-0.3 -1,-0.1 -0.968 81.3-102.1-148.4 159.7 23.8 47.7 18.4 280 294 A S > - 0 0 45 -2,-0.3 3,-1.7 1,-0.1 4,-0.4 -0.513 43.5-106.8 -77.5 154.7 25.7 49.9 16.0 281 295 A F G > S+ 0 0 16 34,-2.6 3,-1.7 1,-0.3 5,-0.4 0.848 117.3 65.1 -48.0 -41.8 28.9 48.5 14.5 282 296 A S G > S+ 0 0 75 33,-0.4 3,-1.0 1,-0.3 -1,-0.3 0.716 85.6 72.2 -63.1 -21.3 30.9 50.9 16.7 283 297 A N G < S+ 0 0 58 -3,-1.7 -1,-0.3 1,-0.2 -2,-0.2 0.795 92.5 57.2 -57.7 -29.4 29.8 49.2 19.9 284 298 A F G < S- 0 0 1 -3,-1.7 -51,-0.5 -4,-0.4 -50,-0.5 0.486 99.0-133.9 -91.6 -5.3 32.0 46.2 19.1 285 299 A R < + 0 0 192 -3,-1.0 2,-0.3 -4,-0.3 -52,-0.1 0.856 45.6 161.3 58.0 43.7 35.3 48.1 19.0 286 300 A L - 0 0 20 -5,-0.4 -1,-0.2 1,-0.1 4,-0.1 -0.672 38.1-156.5 -97.2 152.4 36.5 46.5 15.7 287 301 A K S S+ 0 0 185 -2,-0.3 -1,-0.1 2,-0.1 -278,-0.1 0.176 76.1 56.2-113.9 13.4 39.2 47.7 13.4 288 302 A K S S- 0 0 25 -278,-0.1 -278,-0.2 -280,-0.0 -29,-0.2 -0.918 96.0 -86.0-132.9 163.3 38.0 45.9 10.2 289 303 A P - 0 0 0 0, 0.0 -29,-2.8 0, 0.0 2,-0.4 -0.236 39.5-144.5 -63.6 157.4 34.7 46.0 8.3 290 304 A M E -j 260 0B 0 -280,-0.3 28,-3.1 26,-0.3 29,-0.7 -0.998 9.0-162.9-129.5 130.9 32.0 43.6 9.4 291 305 A V E -jk 261 319B 0 -31,-2.4 -29,-2.2 -2,-0.4 2,-1.1 -0.879 22.9-133.2-103.9 136.4 29.5 41.8 7.2 292 306 A I E -jk 262 320B 0 27,-2.4 29,-2.4 -2,-0.4 -29,-0.2 -0.812 32.4-175.6 -87.6 100.5 26.4 40.3 8.7 293 307 A G E + 0 0 0 -31,-1.5 2,-0.3 -2,-1.1 -30,-0.2 0.531 57.5 23.6 -89.5 -11.2 26.8 37.0 6.8 294 308 A E E S+j 263 0B 7 -32,-0.7 -30,-2.0 -3,-0.1 2,-0.3 -0.927 71.3 119.3-152.6 132.6 23.7 35.0 7.8 295 309 A F - 0 0 0 -2,-0.3 28,-2.4 26,-0.3 2,-0.3 -0.917 26.3-168.3-170.6 166.3 20.3 36.2 9.0 296 310 A N > - 0 0 4 -32,-0.3 3,-0.9 -2,-0.3 28,-0.1 -0.983 36.2-112.9-161.3 163.5 16.6 36.0 8.0 297 311 A Q G > S+ 0 0 58 -2,-0.3 3,-1.7 1,-0.2 5,-0.4 0.827 111.8 66.3 -63.8 -32.7 13.2 37.4 8.8 298 312 A E G 3 S+ 0 0 73 1,-0.3 -1,-0.2 2,-0.1 3,-0.1 0.798 115.7 29.2 -61.3 -27.1 12.0 34.1 10.0 299 313 A H G < S+ 0 0 80 -3,-0.9 -33,-2.0 1,-0.1 -1,-0.3 -0.196 94.6 107.5-122.2 40.1 14.5 34.4 12.9 300 314 A G S X S- 0 0 0 -3,-1.7 3,-2.2 3,-0.2 -2,-0.1 0.124 86.1-115.1-111.3 19.2 14.5 38.2 13.1 301 315 A A T 3 S- 0 0 30 1,-0.3 -30,-0.1 -3,-0.1 3,-0.1 0.834 82.8 -45.9 55.2 38.0 12.6 39.0 16.3 302 316 A G T 3 S+ 0 0 70 -5,-0.4 -1,-0.3 1,-0.3 2,-0.2 0.338 104.1 134.5 87.0 -5.4 9.7 40.6 14.4 303 317 A M < - 0 0 45 -3,-2.2 -1,-0.3 -6,-0.1 -3,-0.2 -0.556 54.5-124.7 -73.9 138.6 12.0 42.7 12.1 304 318 A S > - 0 0 39 -2,-0.2 4,-2.0 1,-0.1 5,-0.2 -0.421 24.8-110.6 -70.9 157.9 11.0 42.8 8.4 305 319 A S H > S+ 0 0 2 1,-0.2 4,-2.4 2,-0.2 5,-0.2 0.895 122.3 54.1 -53.5 -43.5 13.7 41.8 5.7 306 320 A E H > S+ 0 0 52 1,-0.2 4,-2.6 2,-0.2 -1,-0.2 0.911 107.8 48.6 -57.3 -46.3 13.7 45.5 4.7 307 321 A S H > S+ 0 0 60 2,-0.2 4,-2.3 1,-0.2 -1,-0.2 0.844 110.5 51.2 -64.3 -35.4 14.4 46.6 8.3 308 322 A M H X S+ 0 0 0 -4,-2.0 4,-2.2 2,-0.2 -2,-0.2 0.934 112.5 44.5 -70.6 -46.5 17.2 44.1 8.7 309 323 A F H X S+ 0 0 0 -4,-2.4 4,-2.6 1,-0.2 -2,-0.2 0.921 114.5 52.1 -60.3 -41.4 18.9 45.2 5.4 310 324 A E H X S+ 0 0 54 -4,-2.6 4,-2.5 -5,-0.2 -2,-0.2 0.895 107.7 50.0 -61.6 -43.8 18.3 48.9 6.5 311 325 A W H X S+ 0 0 68 -4,-2.3 4,-2.1 2,-0.2 6,-0.3 0.955 113.3 46.1 -60.1 -49.9 19.9 48.3 10.0 312 326 A A H <>S+ 0 0 0 -4,-2.2 5,-1.2 1,-0.2 4,-0.2 0.922 115.7 46.5 -58.7 -44.5 23.0 46.7 8.4 313 327 A Y H <5S+ 0 0 2 -4,-2.6 3,-0.3 1,-0.2 -1,-0.2 0.881 121.6 33.4 -69.3 -39.5 23.3 49.5 5.8 314 328 A T H <5S+ 0 0 39 -4,-2.5 -1,-0.2 -5,-0.2 -2,-0.2 0.603 107.8 63.4 -96.5 -14.7 22.9 52.5 8.1 315 329 A K T <5S- 0 0 85 -4,-2.1 -34,-2.6 -5,-0.2 -33,-0.4 0.189 119.3 -86.0-104.5 19.0 24.5 51.4 11.4 316 330 A G T 5S+ 0 0 35 -3,-0.3 -26,-0.3 1,-0.3 -3,-0.1 0.448 82.9 131.1 103.4 2.2 28.1 50.9 10.2 317 331 A Y < - 0 0 8 -5,-1.2 -1,-0.3 -6,-0.3 -26,-0.2 -0.411 49.3-143.6 -81.3 163.5 28.2 47.4 8.8 318 332 A S S S+ 0 0 2 -28,-3.1 -297,-2.5 1,-0.2 2,-0.3 0.443 70.5 3.2-112.8 1.0 29.7 46.6 5.3 319 333 A G E -dk 21 291B 0 -29,-0.7 -27,-2.4 -299,-0.2 2,-0.3 -0.980 48.5-152.7-174.7 164.6 27.4 43.9 4.1 320 334 A A E -dk 22 292B 0 -299,-2.4 -297,-2.2 -2,-0.3 2,-0.5 -0.917 11.3-178.1-151.8 119.0 24.4 41.7 4.6 321 335 A W E -d 23 0B 0 -29,-2.4 -297,-0.3 -2,-0.3 -26,-0.3 -0.984 19.4-141.4-120.3 118.9 23.8 38.2 3.2 322 336 A T E -d 24 0B 1 -299,-2.0 -297,-2.6 -2,-0.5 2,-0.5 -0.401 27.9 -97.0 -75.1 158.2 20.5 36.4 4.0 323 337 A W S S- 0 0 28 -28,-2.4 -297,-0.1 1,-0.2 -29,-0.1 -0.976 77.2 -12.6-112.9 118.8 20.3 32.7 4.7 324 338 A S - 0 0 0 -2,-0.5 3,-0.4 -299,-0.4 -298,-0.2 0.781 12.7-158.3-153.2 178.7 19.5 31.3 2.0 325 339 A R S S+ 0 0 76 -300,-2.6 -298,-0.2 1,-0.2 -299,-0.1 0.864 116.0 42.1 -57.2 -37.7 18.4 30.4 -1.6 326 340 A T S S+ 0 0 63 -300,-1.1 -1,-0.2 -301,-0.2 2,-0.2 0.718 112.4 60.5 -79.3 -24.7 17.6 26.9 -0.4 327 341 A D S S- 0 0 64 -3,-0.4 0, 0.0 2,-0.1 0, 0.0 -0.681 99.3 -18.7-113.5 158.4 16.0 27.7 3.0 328 342 A V S S- 0 0 73 -2,-0.2 2,-0.6 1,-0.1 -4,-0.1 -0.009 109.9 -15.7 46.2-150.3 12.9 29.7 4.2 329 343 A S > - 0 0 35 1,-0.2 4,-1.1 2,-0.0 -32,-0.1 -0.798 47.8-169.9 -91.1 118.9 11.3 32.3 1.8 330 344 A W H > S+ 0 0 22 -2,-0.6 4,-2.4 1,-0.2 5,-0.2 0.874 89.7 57.9 -68.9 -40.2 13.3 33.4 -1.2 331 345 A N H > S+ 0 0 123 1,-0.2 4,-2.3 2,-0.2 -1,-0.2 0.880 102.6 53.8 -58.4 -38.0 10.8 36.2 -2.0 332 346 A N H > S+ 0 0 28 2,-0.2 4,-1.6 1,-0.2 -1,-0.2 0.874 110.4 48.2 -60.6 -40.7 11.4 37.7 1.5 333 347 A Q H X S+ 0 0 2 -4,-1.1 4,-2.3 2,-0.2 -2,-0.2 0.925 111.4 47.8 -67.5 -45.7 15.1 37.8 0.8 334 348 A L H X S+ 0 0 8 -4,-2.4 4,-2.4 2,-0.2 -2,-0.2 0.873 109.1 54.3 -62.6 -38.7 14.7 39.4 -2.6 335 349 A R H X S+ 0 0 80 -4,-2.3 4,-1.0 -5,-0.2 -1,-0.2 0.895 108.6 50.2 -64.0 -36.9 12.3 42.0 -1.1 336 350 A G H >X S+ 0 0 0 -4,-1.6 3,-0.7 2,-0.2 4,-0.6 0.948 111.5 46.8 -63.5 -50.1 15.0 42.9 1.4 337 351 A M H >< S+ 0 0 0 -4,-2.3 3,-1.3 1,-0.2 4,-0.5 0.896 106.7 58.8 -56.2 -44.6 17.8 43.2 -1.2 338 352 A Q H >< S+ 0 0 90 -4,-2.4 3,-0.9 1,-0.3 4,-0.4 0.783 92.6 68.5 -58.8 -30.0 15.5 45.4 -3.4 339 353 A H H << S+ 0 0 78 -4,-1.0 -1,-0.3 -3,-0.7 3,-0.2 0.821 106.9 38.8 -60.5 -32.0 15.1 47.9 -0.5 340 354 A L T X< S+ 0 0 0 -3,-1.3 3,-2.2 -4,-0.6 -1,-0.2 0.510 84.5 108.8 -94.6 -3.5 18.8 48.9 -1.0 341 355 A K T < S+ 0 0 72 -3,-0.9 9,-0.3 -4,-0.5 8,-0.2 0.822 88.6 28.6 -48.0 -49.8 18.9 48.7 -4.8 342 356 A S T 3 S+ 0 0 112 -4,-0.4 -1,-0.3 -3,-0.2 2,-0.2 0.316 94.2 126.6 -94.4 10.8 19.2 52.5 -5.5 343 357 A R < + 0 0 56 -3,-2.2 6,-1.0 1,-0.1 7,-0.3 -0.427 18.9 155.4 -85.5 140.1 20.9 53.5 -2.3 344 358 A T > + 0 0 102 4,-0.2 3,-1.4 -2,-0.2 -1,-0.1 0.371 48.5 99.2-132.5 -3.1 24.1 55.5 -2.1 345 359 A D T 3 S+ 0 0 84 1,-0.3 3,-0.1 2,-0.1 -2,-0.0 0.696 102.4 22.5 -62.7 -22.9 24.0 57.2 1.4 346 360 A H T 3 S- 0 0 74 1,-0.6 -1,-0.3 -328,-0.1 2,-0.1 -0.183 138.0 -47.4-135.0 41.9 26.3 54.5 3.0 347 361 A G S < S- 0 0 6 -3,-1.4 -1,-0.6 -329,-0.1 -328,-0.3 -0.052 73.7 -67.8 106.7 150.7 28.1 53.3 -0.1 348 362 A Q B -c 19 0A 72 -330,-2.8 -328,-1.8 1,-0.2 -4,-0.2 -0.496 35.5-179.9 -72.0 136.3 27.1 52.1 -3.6 349 363 A V S S+ 0 0 0 -6,-1.0 2,-0.8 1,-0.2 -327,-0.2 0.749 75.9 54.4-101.5 -39.4 25.1 48.9 -3.9 350 364 A Q S S+ 0 0 78 -7,-0.3 2,-0.3 -9,-0.3 -1,-0.2 -0.868 73.7 147.6 -97.8 106.1 24.8 48.9 -7.7 351 365 A F - 0 0 24 -2,-0.8 2,-0.2 -247,-0.2 -332,-0.0 -0.985 45.1-115.0-137.3 150.0 28.2 49.1 -9.2 352 366 A G 0 0 49 -2,-0.3 -2,-0.0 1,-0.1 -247,-0.0 -0.576 360.0 360.0 -83.5 146.3 29.8 47.8 -12.3 353 367 A L 0 0 43 -2,-0.2 -1,-0.1 -252,-0.2 -338,-0.1 0.794 360.0 360.0 -82.8 360.0 32.6 45.2 -12.2