==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=26-NOV-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER IMMUNE SYSTEM 01-SEP-99 1CZ8 . COMPND 2 MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR Y.CHEN,C.WIESMANN,G.FUH,B.LI,H.W.CHRISTINGER,P.MCKAY,A.M.DE . 1050 8 16 14 2 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 46255.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 712 67.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 38 3.6 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 405 38.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 9 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 6 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 4 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 2 0.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 122 11.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 83 7.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 40 3.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 8 0.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 5 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 6 2 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 8 9 13 4 10 17 1 3 2 1 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 2 1 9 4 1 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 14 V V 0 0 104 0, 0.0 2,-0.4 0, 0.0 159,-0.2 0.000 360.0 360.0 360.0 140.8 6.3 -21.2 13.6 2 15 V V B -a 160 0A 19 157,-2.7 159,-2.7 1,-0.1 2,-0.1 -0.604 360.0-123.2 -78.7 125.5 10.0 -22.1 14.0 3 16 V K >> - 0 0 123 -2,-0.4 4,-2.4 157,-0.2 3,-0.6 -0.393 18.5-119.7 -66.3 141.0 11.3 -22.1 17.5 4 17 V F H 3> S+ 0 0 13 1,-0.2 4,-2.9 2,-0.2 5,-0.2 0.883 112.8 55.6 -45.7 -49.5 14.3 -19.8 18.2 5 18 V M H 3> S+ 0 0 117 2,-0.2 4,-2.7 1,-0.2 -1,-0.2 0.906 111.6 44.2 -54.1 -44.6 16.4 -22.7 19.3 6 19 V D H <> S+ 0 0 72 -3,-0.6 4,-3.1 2,-0.2 5,-0.4 0.986 111.6 49.8 -63.8 -61.7 15.8 -24.5 16.0 7 20 V V H X S+ 0 0 0 -4,-2.4 4,-1.6 1,-0.2 -2,-0.2 0.903 115.8 47.9 -42.2 -46.7 16.3 -21.5 13.8 8 21 V Y H X S+ 0 0 52 -4,-2.9 4,-0.8 -5,-0.3 -1,-0.2 0.898 114.0 42.1 -63.7 -49.0 19.5 -21.0 15.7 9 22 V Q H >< S+ 0 0 122 -4,-2.7 3,-0.6 -5,-0.2 -2,-0.2 0.930 116.0 50.3 -66.5 -43.8 20.9 -24.5 15.6 10 23 V R H 3< S+ 0 0 93 -4,-3.1 -2,-0.2 1,-0.2 -1,-0.2 0.755 115.3 40.9 -67.4 -26.4 19.9 -25.0 12.0 11 24 V S H 3< S+ 0 0 0 -4,-1.6 36,-2.1 -5,-0.4 2,-0.3 0.499 87.1 114.1-102.9 -0.3 21.5 -21.8 10.7 12 25 V Y B << S-d 47 0B 86 -4,-0.8 36,-0.2 -3,-0.6 33,-0.1 -0.558 86.0 -71.4 -79.0 133.3 24.7 -21.8 12.7 13 26 V a S S+ 0 0 9 34,-2.8 33,-0.2 -2,-0.3 -1,-0.2 0.302 81.4 122.2 -18.3 119.1 28.1 -22.2 10.9 14 27 V H E -E 45 0C 52 31,-2.0 31,-2.7 29,-0.1 2,-0.5 -0.964 68.2 -68.9-178.1 162.9 28.4 -25.8 9.6 15 28 V P E +E 44 0C 39 0, 0.0 2,-0.4 0, 0.0 29,-0.3 -0.576 55.4 176.2 -69.6 117.7 28.9 -28.0 6.4 16 29 V I E -E 43 0C 29 27,-3.2 27,-1.0 -2,-0.5 25,-0.1 -0.985 41.0 -93.4-128.4 134.5 25.7 -27.7 4.3 17 30 V E E -E 42 0C 60 -2,-0.4 2,-0.4 25,-0.2 25,-0.2 -0.194 49.3-174.7 -45.9 122.4 25.0 -29.2 0.8 18 31 V T E -E 41 0C 56 23,-2.2 23,-3.0 21,-0.1 2,-1.1 -0.992 26.2-131.2-127.8 130.1 25.9 -26.5 -1.7 19 32 V L E -E 40 0C 35 -2,-0.4 2,-0.4 21,-0.2 122,-0.2 -0.703 32.9-162.4 -85.6 100.5 25.4 -26.7 -5.5 20 33 V V E -E 39 0C 10 19,-3.1 19,-2.5 -2,-1.1 2,-0.7 -0.703 20.6-122.6 -93.3 133.7 28.7 -25.7 -6.9 21 34 V D E >> -E 38 0C 68 -2,-0.4 4,-1.6 17,-0.2 3,-1.3 -0.599 19.6-149.2 -72.9 109.8 29.3 -24.6 -10.5 22 35 V I H 3> S+ 0 0 0 15,-2.1 4,-2.4 -2,-0.7 -1,-0.2 0.857 95.8 54.9 -48.2 -45.7 32.0 -27.0 -11.8 23 36 V F H 34 S+ 0 0 90 14,-0.6 -1,-0.3 1,-0.2 6,-0.2 0.845 105.3 56.2 -61.9 -28.6 33.5 -24.5 -14.2 24 37 V Q H <4 S+ 0 0 119 -3,-1.3 -2,-0.2 1,-0.2 -1,-0.2 0.984 108.0 45.8 -64.1 -56.6 33.9 -22.2 -11.2 25 38 V E H < S+ 0 0 56 -4,-1.6 -2,-0.2 1,-0.3 -1,-0.2 0.944 122.9 35.7 -49.4 -58.0 36.0 -24.9 -9.3 26 39 V Y S >< S+ 0 0 75 -4,-2.4 3,-1.4 1,-0.2 -1,-0.3 -0.712 71.0 174.7 -99.6 84.1 38.1 -25.7 -12.3 27 40 V P T 3 S+ 0 0 79 0, 0.0 3,-0.2 0, 0.0 -1,-0.2 0.634 74.7 66.2 -66.1 -9.0 38.5 -22.3 -13.9 28 41 V D T 3 S+ 0 0 133 1,-0.2 2,-2.0 -3,-0.1 3,-0.4 0.751 73.3 86.9 -82.6 -24.9 40.9 -23.8 -16.4 29 42 V E X + 0 0 30 -3,-1.4 3,-2.3 1,-0.2 -1,-0.2 0.047 52.6 145.8 -65.9 33.0 38.2 -26.0 -18.0 30 43 V I T 3 + 0 0 114 -2,-2.0 -1,-0.2 1,-0.3 -2,-0.1 0.865 65.7 43.4 -37.7 -60.5 37.4 -23.1 -20.3 31 44 V E T 3 S+ 0 0 103 -3,-0.4 2,-0.3 40,-0.0 -1,-0.3 0.258 98.2 90.2 -79.0 13.8 36.6 -25.2 -23.4 32 45 V Y < - 0 0 33 -3,-2.3 2,-0.4 39,-0.1 39,-0.2 -0.752 57.5-151.9-110.4 159.5 34.5 -27.9 -21.8 33 46 V I E -F 70 0D 76 37,-1.7 37,-1.7 -2,-0.3 2,-0.4 -0.935 19.5-150.2-120.6 144.3 30.8 -28.2 -21.1 34 47 V F E -F 69 0D 10 -2,-0.4 35,-0.2 35,-0.2 -11,-0.1 -0.923 9.6-130.2-123.8 149.5 29.7 -30.3 -18.2 35 48 V K E S+F 68 0D 31 33,-1.8 33,-2.3 -2,-0.4 2,-0.2 -0.950 107.6 25.0-133.5 108.2 26.6 -32.4 -17.5 36 49 V P S S- 0 0 0 0, 0.0 -1,-0.2 0, 0.0 67,-0.1 0.679 83.9-158.7 -72.6 167.5 25.7 -31.6 -14.7 37 50 V S S S+ 0 0 28 -2,-0.2 -15,-2.1 66,-0.1 -14,-0.6 0.619 78.2 37.4 -88.2 -13.2 27.2 -28.1 -14.8 38 51 V b E S-E 21 0C 5 -17,-0.3 -17,-0.2 -16,-0.1 68,-0.2 -0.938 71.6-148.9-137.2 156.5 27.0 -28.1 -11.0 39 52 V V E -E 20 0C 0 -19,-2.5 -19,-3.1 -2,-0.3 2,-0.9 -0.943 24.4-112.7-130.9 151.7 27.5 -30.6 -8.2 40 53 V P E +E 19 0C 1 0, 0.0 2,-0.4 0, 0.0 -21,-0.2 -0.709 46.3 175.3 -81.0 102.3 26.1 -31.1 -4.6 41 54 V L E -E 18 0C 0 -23,-3.0 -23,-2.2 -2,-0.9 2,-0.3 -0.941 36.4-118.3-117.7 133.6 29.1 -30.5 -2.3 42 55 V M E +E 17 0C 79 -2,-0.4 44,-1.6 -25,-0.2 2,-0.4 -0.490 50.9 172.4 -65.0 121.0 29.3 -30.4 1.5 43 56 V R E -E 16 0C 37 -27,-1.0 -27,-3.2 -2,-0.3 -29,-0.1 -0.990 41.2 -97.0-145.9 143.4 30.4 -26.9 2.3 44 57 V c E +E 15 0C 31 -2,-0.4 2,-0.3 -29,-0.3 -31,-0.1 -0.268 59.2 149.4 -53.4 119.5 30.9 -24.4 5.1 45 58 V G E +E 14 0C 18 -31,-2.7 -31,-2.0 -33,-0.1 2,-0.3 -0.988 18.8 64.5-153.6 149.7 27.7 -22.3 5.3 46 59 V G S S- 0 0 27 -2,-0.3 2,-0.3 -33,-0.2 -34,-0.2 -0.864 71.0 -69.7 132.7-168.2 25.8 -20.6 8.0 47 60 V d B -d 12 0B 12 -36,-2.1 -34,-2.8 -2,-0.3 7,-0.1 -0.832 10.8-157.2-126.0 163.5 26.4 -17.7 10.4 48 61 V e - 0 0 17 -2,-0.3 -1,-0.1 -36,-0.2 6,-0.1 0.391 36.2-133.1-112.9 -7.8 28.5 -16.9 13.4 49 62 V N S S+ 0 0 18 1,-0.1 2,-0.3 4,-0.1 3,-0.1 0.879 76.8 104.2 55.2 36.4 26.2 -14.1 14.7 50 63 V D > - 0 0 84 3,-0.1 3,-1.5 1,-0.1 -1,-0.1 -0.880 64.1-153.8-152.1 112.5 29.4 -12.2 15.2 51 64 V E T 3 S+ 0 0 170 -2,-0.3 -1,-0.1 1,-0.3 -2,-0.1 0.862 101.2 53.1 -53.9 -34.0 30.6 -9.4 12.9 52 65 V G T 3 S+ 0 0 39 -3,-0.1 42,-1.6 -4,-0.1 -1,-0.3 0.613 104.6 60.5 -79.5 -12.9 34.1 -10.3 14.1 53 66 V L E < - G 0 93D 47 -3,-1.5 2,-0.3 40,-0.2 -5,-0.1 -0.427 61.4-159.8-107.0-177.6 34.1 -14.0 13.3 54 67 V E E - G 0 92D 72 38,-0.6 38,-2.4 -2,-0.1 2,-0.5 -0.957 24.9-112.2-164.1 144.6 33.6 -16.1 10.2 55 68 V a E + G 0 91D 34 -2,-0.3 36,-0.2 -9,-0.2 -9,-0.1 -0.691 47.0 160.3 -81.5 122.9 32.6 -19.6 9.2 56 69 V V E - G 0 90D 40 34,-1.9 34,-2.3 -2,-0.5 2,-0.2 -0.952 40.7 -99.3-139.9 158.9 35.6 -21.5 7.7 57 70 V P E + G 0 89D 43 0, 0.0 32,-0.3 0, 0.0 3,-0.1 -0.586 29.4 174.8 -82.8 142.2 36.5 -25.2 7.2 58 71 V T E S+ 0 0 62 30,-3.1 2,-0.4 1,-0.3 31,-0.2 0.457 75.9 40.7-119.7 -12.5 38.8 -27.0 9.6 59 72 V E E S+ G 0 88D 99 29,-1.4 28,-3.9 2,-0.0 29,-1.8 -0.940 70.6 179.9-142.1 115.1 38.4 -30.4 8.1 60 73 V E E + G 0 86D 106 -2,-0.4 2,-0.3 26,-0.3 26,-0.2 -0.609 3.0 170.7-109.6 171.2 38.3 -31.0 4.3 61 74 V S E - 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