==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE/HYDROLASE INHIBITOR 17-JAN-00 1DXW . COMPND 2 MOLECULE: SERINE PROTEASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HEPATITIS C VIRUS; . AUTHOR G.BARBATO,D.O.CICERO,F.CORDIER,F.NARJES,B.GERLACH,S.SAMBUCIN . 165 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 8702.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 105 63.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 4 2.4 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 50 30.3 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 1.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 6 3.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 20 12.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 13 7.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 10 6.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 2 2 2 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 22 A T 0 0 158 0, 0.0 64,-0.1 0, 0.0 2,-0.0 0.000 360.0 360.0 360.0 58.0 -23.3 -4.6 -6.5 2 23 A G - 0 0 34 48,-0.1 48,-0.2 1,-0.1 50,-0.0 -0.118 360.0 -79.3 88.9 167.5 -22.2 -1.2 -4.9 3 24 A R + 0 0 107 46,-0.4 -1,-0.1 45,-0.2 47,-0.1 0.994 56.1 166.5 -70.0 -61.3 -23.9 2.2 -5.5 4 25 A D + 0 0 43 44,-0.3 2,-0.2 1,-0.1 4,-0.1 0.910 27.1 141.5 48.4 50.0 -22.3 3.0 -8.9 5 26 A K + 0 0 107 64,-0.1 -1,-0.1 43,-0.1 43,-0.1 -0.670 32.7 43.7-115.3 172.5 -24.7 5.9 -9.6 6 27 A N S S- 0 0 129 -2,-0.2 2,-0.1 41,-0.1 41,-0.0 0.673 98.2 -80.8 63.8 123.9 -24.3 9.3 -11.3 7 28 A Q - 0 0 145 1,-0.2 62,-0.2 2,-0.1 -2,-0.1 -0.334 43.9-171.4 -58.1 127.4 -22.1 9.3 -14.5 8 29 A V + 0 0 41 60,-0.5 -1,-0.2 -2,-0.1 61,-0.1 0.928 9.5 174.0 -86.4 -53.3 -18.4 9.3 -13.5 9 30 A E + 0 0 132 1,-0.2 2,-0.4 59,-0.2 -2,-0.1 0.860 38.1 128.5 48.2 37.4 -16.8 9.9 -16.9 10 31 A G - 0 0 19 1,-0.1 61,-0.8 59,-0.0 62,-0.5 -0.977 55.8-153.1-126.0 134.1 -13.4 10.1 -15.1 11 32 A E S S+ 0 0 83 -2,-0.4 15,-2.2 1,-0.2 2,-0.4 0.905 90.9 29.4 -69.9 -40.1 -10.2 8.2 -16.0 12 33 A V E S-A 25 0A 42 13,-0.2 2,-0.5 60,-0.1 13,-0.2 -0.976 72.8-163.0-123.5 130.0 -8.9 8.4 -12.4 13 34 A Q E -A 24 0A 34 11,-2.5 11,-0.7 -2,-0.4 2,-0.3 -0.938 11.8-142.5-116.6 127.8 -11.2 8.6 -9.3 14 35 A V E +A 23 0A 78 -2,-0.5 2,-0.3 9,-0.2 9,-0.2 -0.664 32.1 166.4 -84.3 136.2 -10.0 9.7 -5.9 15 36 A V E -A 22 0A 8 7,-1.0 7,-1.7 -2,-0.3 2,-0.4 -0.889 28.0-134.7-142.9 174.7 -11.5 7.8 -3.0 16 37 A S E -A 21 0A 58 -2,-0.3 5,-0.3 5,-0.2 2,-0.2 -0.998 16.1-169.2-138.2 136.2 -11.1 7.2 0.8 17 38 A T - 0 0 11 3,-3.7 26,-0.1 -2,-0.4 25,-0.1 -0.554 48.7 -84.0-113.6 179.9 -11.3 4.0 2.7 18 39 A A S S+ 0 0 99 23,-0.5 20,-0.1 20,-0.3 3,-0.1 0.699 130.8 38.9 -60.9 -15.6 -11.4 3.2 6.4 19 40 A T S S- 0 0 92 18,-0.5 2,-0.3 1,-0.3 -1,-0.2 0.792 125.6 -47.5-104.8 -36.7 -7.6 3.5 6.4 20 41 A Q - 0 0 91 17,-0.6 -3,-3.7 18,-0.1 2,-0.4 -0.964 53.7 -86.0-173.6-169.1 -6.8 6.5 4.1 21 42 A S E +A 16 0A 43 -5,-0.3 -5,-0.2 -2,-0.3 2,-0.2 -0.943 50.8 128.8-123.7 143.8 -7.4 8.2 0.7 22 43 A F E -A 15 0A 1 -7,-1.7 -7,-1.0 -2,-0.4 2,-0.3 -0.573 48.3 -65.4-160.3-138.1 -5.5 7.6 -2.6 23 44 A L E -A 14 0A 1 95,-1.7 11,-0.8 -9,-0.2 2,-0.3 -0.899 22.3-164.3-135.4 166.6 -6.4 6.8 -6.3 24 45 A A E -AB 13 33A 2 -11,-0.7 -11,-2.5 -2,-0.3 2,-0.5 -0.946 12.8-150.7-150.0 122.8 -8.0 4.2 -8.6 25 46 A T E -AB 12 32A 0 7,-3.0 7,-2.7 94,-0.4 2,-0.4 -0.840 17.0-131.2-101.1 127.2 -7.7 4.1 -12.4 26 47 A C E + B 0 31A 0 -15,-2.2 47,-3.3 -2,-0.5 2,-0.4 -0.582 35.3 170.6 -74.1 123.1 -10.5 2.6 -14.5 27 48 A V E > -cB 73 30A 1 3,-3.0 3,-0.9 -2,-0.4 47,-0.1 -0.986 62.4 -11.6-139.0 130.0 -9.1 0.1 -17.0 28 49 A N T 3 S- 0 0 50 45,-1.2 -1,-0.1 -2,-0.4 3,-0.1 0.890 130.3 -52.2 52.7 40.0 -11.0 -2.4 -19.3 29 50 A G T 3 S+ 0 0 27 1,-0.2 2,-0.4 44,-0.2 -1,-0.3 0.825 122.7 109.0 68.2 28.0 -14.2 -1.6 -17.4 30 51 A V E < -B 27 0A 16 -3,-0.9 -3,-3.0 35,-0.2 2,-0.5 -0.942 65.2-139.3-140.0 117.0 -12.4 -2.4 -14.1 31 52 A C E -B 26 0A 6 -2,-0.4 33,-2.5 -5,-0.3 2,-0.5 -0.613 22.9-163.9 -76.3 123.0 -11.4 0.3 -11.5 32 53 A W E +BD 25 63A 0 -7,-2.7 -7,-3.0 -2,-0.5 2,-0.2 -0.924 16.8 160.1-113.5 130.0 -7.9 -0.5 -10.2 33 54 A T E -BD 24 62A 4 29,-1.8 29,-1.3 -2,-0.5 2,-0.5 -0.743 46.3 -77.9-133.1-179.7 -6.5 1.0 -7.0 34 55 A V E > - D 0 61A 0 -11,-0.8 4,-1.2 -2,-0.2 27,-0.2 -0.721 25.0-147.6 -90.7 131.0 -3.7 0.2 -4.6 35 56 A Y H > S+ 0 0 73 25,-0.9 2,-3.1 -2,-0.5 4,-0.9 0.901 91.9 74.1 -59.9 -40.0 -4.4 -2.6 -2.0 36 57 A H H 4 S+ 0 0 65 24,-0.3 -1,-0.2 1,-0.2 -2,-0.1 -0.351 108.6 30.2 -74.8 68.7 -2.1 -0.8 0.5 37 58 A G H 4 S+ 0 0 6 -2,-3.1 -17,-0.6 -4,-0.1 -18,-0.5 0.005 117.0 53.2 172.0 -38.4 -4.8 1.8 1.1 38 59 A A H < + 0 0 1 -4,-1.2 2,-1.2 -3,-0.4 -20,-0.3 0.971 62.6 151.3 -80.0 -66.8 -8.2 -0.0 0.5 39 60 A G S < S+ 0 0 30 -4,-0.9 2,-0.6 1,-0.2 -1,-0.2 -0.562 77.2 27.0 74.5 -98.8 -7.8 -3.1 2.8 40 61 A S S S- 0 0 97 -2,-1.2 -1,-0.2 1,-0.3 -22,-0.1 -0.208 102.0-134.5 -91.3 46.4 -11.4 -3.9 3.7 41 62 A K + 0 0 76 -2,-0.6 -23,-0.5 1,-0.1 -1,-0.3 -0.013 64.9 123.3 37.5-130.3 -12.8 -2.4 0.4 42 63 A T + 0 0 74 8,-0.4 9,-0.2 -25,-0.1 -24,-0.2 0.931 39.7 151.0 47.3 54.1 -15.8 -0.1 1.2 43 64 A L - 0 0 15 7,-1.1 2,-0.4 -26,-0.1 -26,-0.1 0.409 53.0 -78.2 -86.9-132.8 -14.3 3.0 -0.4 44 65 A A - 0 0 41 5,-0.2 -27,-0.0 -41,-0.0 -1,-0.0 -0.887 41.7-169.9-141.3 109.0 -16.4 5.8 -2.0 45 66 A G - 0 0 16 3,-3.7 -43,-0.0 -2,-0.4 5,-0.0 0.291 63.1 -53.4 -73.1-149.5 -18.0 5.4 -5.4 46 67 A P S S- 0 0 47 0, 0.0 -1,-0.1 0, 0.0 -40,-0.1 0.853 132.1 -18.2 -60.2 -32.2 -19.6 8.3 -7.3 47 68 A K S S+ 0 0 123 1,-0.3 -41,-0.1 -41,-0.0 -3,-0.0 0.397 130.2 41.1-153.3 -2.7 -21.8 8.8 -4.1 48 69 A G S S- 0 0 9 -43,-0.1 -3,-3.7 0, 0.0 -1,-0.3 -0.976 90.7 -77.2-148.9 162.4 -21.7 5.7 -1.9 49 70 A P - 0 0 85 0, 0.0 -46,-0.4 0, 0.0 2,-0.3 -0.410 48.6-157.3 -63.2 125.8 -19.4 3.0 -0.6 50 71 A I - 0 0 25 -2,-0.2 -7,-1.1 -48,-0.2 -8,-0.4 -0.755 11.3-124.5-104.9 152.6 -18.7 0.4 -3.3 51 72 A T - 0 0 70 -2,-0.3 14,-0.4 -9,-0.2 2,-0.1 -0.721 25.5-115.3 -96.2 144.8 -17.5 -3.2 -2.8 52 73 A Q - 0 0 48 -2,-0.3 12,-0.2 1,-0.1 3,-0.1 -0.435 15.9-159.2 -75.9 151.4 -14.3 -4.6 -4.4 53 74 A M S S+ 0 0 81 10,-0.6 2,-0.3 1,-0.3 11,-0.2 0.817 71.3 5.6 -98.8 -39.8 -14.7 -7.4 -7.0 54 75 A Y E -E 63 0A 24 9,-1.6 9,-0.8 108,-0.1 -1,-0.3 -0.917 56.9-160.8-140.0 166.7 -11.1 -8.9 -6.9 55 76 A T E -E 62 0A 31 -2,-0.3 2,-1.5 7,-0.2 7,-0.3 -0.807 8.5-162.5-154.7 111.1 -7.9 -8.5 -5.0 56 77 A N E >>> +E 61 0A 26 5,-2.4 5,-1.3 -2,-0.3 3,-1.1 -0.609 20.5 168.1 -91.9 78.6 -4.3 -9.5 -6.0 57 78 A V G >45S+ 0 0 84 -2,-1.5 3,-0.8 1,-0.3 -1,-0.2 0.925 75.9 61.1 -60.0 -40.0 -2.7 -9.4 -2.6 58 79 A D G 345S+ 0 0 138 1,-0.3 -1,-0.3 -3,-0.2 -2,-0.1 0.831 119.8 29.2 -55.7 -26.2 0.3 -11.2 -3.9 59 80 A Q G <45S- 0 0 71 -3,-1.1 -1,-0.3 2,-0.2 -2,-0.3 0.401 111.7-120.5-111.7 -0.7 0.6 -8.2 -6.3 60 81 A D T <<5S+ 0 0 27 -4,-1.0 -25,-0.9 -3,-0.8 2,-0.3 0.984 70.0 124.5 59.9 57.8 -1.0 -5.6 -3.9 61 82 A L E < -DE 34 56A 0 -5,-1.3 -5,-2.4 -27,-0.2 2,-0.4 -0.994 41.4-167.0-146.2 152.4 -3.8 -4.7 -6.3 62 83 A V E -DE 33 55A 0 -29,-1.3 -29,-1.8 -2,-0.3 2,-0.5 -0.982 5.9-163.9-143.1 127.6 -7.7 -4.6 -6.2 63 84 A G E -DE 32 54A 0 -9,-0.8 -9,-1.6 -2,-0.4 -10,-0.6 -0.942 3.8-162.5-120.3 124.0 -10.0 -4.3 -9.2 64 85 A W - 0 0 11 -33,-2.5 2,-0.7 -2,-0.5 -12,-0.1 -0.175 35.2 -99.7 -84.7-174.9 -13.7 -3.4 -8.9 65 86 A Q - 0 0 100 -14,-0.4 -35,-0.2 -35,-0.2 -36,-0.1 -0.613 45.3-175.6-110.1 73.7 -16.4 -3.9 -11.6 66 87 A A + 0 0 11 -2,-0.7 4,-0.1 -37,-0.2 -39,-0.0 -0.515 19.6 143.1 -70.3 130.9 -16.6 -0.4 -13.2 67 88 A P S > S+ 0 0 69 0, 0.0 3,-0.6 0, 0.0 -1,-0.1 0.338 73.2 3.7-134.1 -92.0 -19.3 -0.2 -15.9 68 89 A P T 3 S+ 0 0 102 0, 0.0 -60,-0.5 0, 0.0 -59,-0.2 0.443 126.0 64.7 -81.9 8.6 -21.6 2.9 -16.4 69 90 A G T 3 S+ 0 0 8 -62,-0.2 2,-0.2 -61,-0.1 -64,-0.1 -0.200 98.7 51.1-118.5 43.6 -19.6 4.8 -13.7 70 91 A A < - 0 0 15 -3,-0.6 -59,-0.1 1,-0.1 -1,-0.1 -0.831 61.7-144.2-175.4 134.7 -16.1 4.9 -15.3 71 92 A R - 0 0 163 -61,-0.8 -60,-0.2 -2,-0.2 -1,-0.1 0.813 42.0-149.6 -73.5 -28.5 -14.6 6.0 -18.7 72 93 A S - 0 0 28 -62,-0.5 -45,-0.3 -45,-0.1 2,-0.1 0.811 6.6-126.9 59.7 115.4 -12.1 3.2 -18.5 73 94 A L B -c 27 0A 22 -47,-3.3 -45,-1.2 -62,-0.2 -44,-0.2 -0.394 27.3 -97.9 -85.7 167.1 -8.7 4.0 -20.2 74 95 A T B -f 128 0B 75 53,-0.9 55,-0.5 1,-0.2 -1,-0.1 -0.722 24.6-150.6 -89.5 135.2 -7.1 1.7 -22.8 75 96 A P + 0 0 24 0, 0.0 -1,-0.2 0, 0.0 56,-0.0 0.964 32.6 154.8 -66.1 -85.3 -4.4 -0.7 -21.6 76 97 A C - 0 0 46 1,-0.1 48,-0.1 54,-0.0 52,-0.0 0.788 48.0-127.7 59.3 115.0 -2.0 -1.1 -24.7 77 98 A T - 0 0 110 74,-0.0 -1,-0.1 47,-0.0 74,-0.0 0.885 36.5-157.8 -61.1 -40.0 1.5 -2.2 -23.7 78 99 A C - 0 0 31 1,-0.1 -2,-0.0 46,-0.0 52,-0.0 0.807 20.3-134.9 61.8 117.3 3.1 0.7 -25.8 79 100 A G S S+ 0 0 79 2,-0.0 -1,-0.1 0, 0.0 2,-0.1 0.917 91.5 75.2 -67.0 -38.7 6.8 0.2 -26.8 80 101 A S - 0 0 74 1,-0.1 44,-0.0 2,-0.1 16,-0.0 -0.397 67.3-161.4 -70.5 148.9 7.4 3.8 -25.7 81 102 A S + 0 0 11 -2,-0.1 2,-2.8 43,-0.1 16,-1.8 0.236 47.2 126.6-117.5 14.6 7.6 4.3 -21.9 82 103 A D E +G 96 0C 60 14,-0.2 14,-0.2 12,-0.1 -2,-0.1 -0.404 41.9 167.5 -72.2 75.8 7.0 8.1 -21.7 83 104 A L E -G 95 0C 4 -2,-2.8 12,-2.4 12,-2.0 2,-0.4 -0.263 27.6-139.8 -84.3 176.2 4.1 7.7 -19.3 84 105 A Y E -GH 94 123C 78 39,-0.5 39,-2.6 10,-0.3 2,-0.3 -0.995 10.6-156.7-141.0 131.9 2.4 10.5 -17.2 85 106 A L E -G 93 0C 4 8,-2.4 8,-1.8 -2,-0.4 2,-0.4 -0.849 1.4-155.2-113.0 148.1 1.3 10.3 -13.6 86 107 A V - 0 0 40 35,-0.5 5,-0.3 -2,-0.3 6,-0.1 -0.956 13.8-136.6-120.0 135.9 -1.4 12.3 -11.7 87 108 A T - 0 0 2 3,-2.6 30,-0.1 -2,-0.4 27,-0.1 -0.197 51.9 -69.8 -81.1 179.9 -1.4 12.9 -7.9 88 109 A R S S+ 0 0 120 1,-0.2 -74,-0.1 27,-0.1 -1,-0.1 0.782 136.0 12.8 -41.9 -29.9 -4.6 12.7 -5.8 89 110 A H S S- 0 0 120 -75,-0.0 -1,-0.2 0, 0.0 -75,-0.1 0.753 131.6 -56.9-116.7 -50.0 -5.8 15.9 -7.5 90 111 A A + 0 0 42 1,-0.0 -3,-2.6 -5,-0.0 0, 0.0 -0.022 55.1 156.2-156.9 -93.6 -3.5 16.6 -10.6 91 112 A D - 0 0 23 -5,-0.3 2,-1.2 1,-0.2 -4,-0.1 0.962 33.5-155.8 47.1 73.7 0.3 17.0 -10.8 92 113 A V + 0 0 108 -6,-0.1 -1,-0.2 -8,-0.1 -6,-0.2 -0.660 27.6 160.6 -82.6 100.0 0.8 16.0 -14.4 93 114 A I E -G 85 0C 26 -8,-1.8 -8,-2.4 -2,-1.2 2,-0.4 -0.908 39.1-119.7-121.0 150.0 4.4 14.8 -14.6 94 115 A P E -G 84 0C 42 0, 0.0 12,-1.8 0, 0.0 2,-0.4 -0.732 28.9-174.5 -90.4 133.0 6.1 12.6 -17.1 95 116 A V E -GI 83 105C 0 -12,-2.4 -12,-2.0 -2,-0.4 2,-0.7 -0.984 19.0-141.8-127.6 130.0 7.6 9.3 -15.9 96 117 A R E -GI 82 104C 115 8,-1.9 8,-3.9 -2,-0.4 2,-0.2 -0.780 28.8-122.1 -90.3 118.2 9.7 6.9 -18.1 97 118 A R E - I 0 103C 68 -16,-1.8 6,-0.3 -2,-0.7 3,-0.1 -0.404 25.3-173.0 -62.1 125.8 8.8 3.3 -17.1 98 119 A R E S- 0 0 166 4,-2.2 2,-0.3 1,-0.3 5,-0.2 0.370 70.9 -23.7 -98.4 4.4 11.9 1.5 -16.0 99 120 A G E > S- I 0 102C 19 3,-1.4 3,-1.5 1,-0.1 -1,-0.3 -0.914 83.4 -74.3 167.0 170.7 10.0 -1.9 -15.8 100 121 A D T 3 S+ 0 0 104 1,-0.3 51,-0.1 -2,-0.3 52,-0.1 0.754 136.7 31.7 -60.8 -19.7 6.4 -3.2 -15.5 101 122 A S T 3 S+ 0 0 64 46,-0.1 47,-0.7 1,-0.1 2,-0.3 0.192 116.6 61.6-121.6 16.0 6.7 -2.2 -11.8 102 123 A R E < -IJ 99 147C 125 -3,-1.5 -4,-2.2 45,-0.3 -3,-1.4 -0.997 50.0-179.3-146.1 143.3 9.0 0.8 -11.9 103 124 A G E -IJ 97 146C 0 43,-3.0 43,-3.5 -2,-0.3 2,-0.8 -0.999 28.1-125.4-140.5 141.8 8.9 4.3 -13.5 104 125 A S E -I 96 0C 34 -8,-3.9 -8,-1.9 -2,-0.4 2,-0.8 -0.765 22.0-140.8 -90.3 111.6 11.5 7.1 -13.5 105 126 A L E -I 95 0C 18 -2,-0.8 -10,-0.2 -10,-0.2 -21,-0.0 -0.575 8.0-160.6 -73.6 109.9 9.9 10.4 -12.2 106 127 A L S S+ 0 0 102 -12,-1.8 -1,-0.2 -2,-0.8 -11,-0.1 0.831 85.1 50.7 -60.0 -30.0 11.4 13.1 -14.4 107 128 A S S S- 0 0 43 -13,-0.3 -1,-0.2 -3,-0.1 36,-0.1 -0.842 83.5-151.2-114.2 97.7 10.4 15.6 -11.7 108 129 A P + 0 0 72 0, 0.0 36,-0.1 0, 0.0 30,-0.0 -0.362 25.0 169.7 -64.9 142.2 11.6 14.6 -8.2 109 130 A R B -K 143 0C 105 34,-0.6 34,-2.5 -2,-0.0 2,-0.1 -0.976 45.1 -71.0-150.0 161.1 9.4 15.9 -5.4 110 131 A P >> - 0 0 58 0, 0.0 3,-2.3 0, 0.0 4,-0.9 -0.340 40.2-135.0 -57.8 122.8 8.9 15.4 -1.7 111 132 A V G >4 S+ 0 0 26 30,-0.4 3,-0.6 1,-0.3 4,-0.3 0.816 104.2 69.6 -50.0 -28.7 7.4 11.9 -1.2 112 133 A S G >4 S+ 0 0 85 29,-0.3 3,-1.2 1,-0.3 -1,-0.3 0.884 95.1 53.9 -59.0 -34.9 5.0 13.6 1.3 113 134 A Y G <4 S+ 0 0 66 -3,-2.3 -1,-0.3 1,-0.3 -2,-0.2 0.812 103.9 55.8 -70.0 -27.3 3.4 15.3 -1.7 114 135 A L G XX S+ 0 0 9 -4,-0.9 3,-2.4 -3,-0.6 2,-0.7 0.403 75.9 125.5 -85.5 5.6 3.0 11.8 -3.3 115 136 A K T <4 S+ 0 0 125 -3,-1.2 -27,-0.1 1,-0.3 -3,-0.1 -0.510 86.5 11.8 -68.1 110.2 1.0 10.6 -0.2 116 137 A G T 34 S+ 0 0 10 -2,-0.7 -1,-0.3 -29,-0.1 -2,-0.1 0.290 98.8 106.4 101.4 -7.0 -2.2 9.4 -1.8 117 138 A S T X4 + 0 0 1 -3,-2.4 3,-1.4 -30,-0.1 16,-0.2 0.730 56.2 99.2 -74.9 -17.9 -0.8 9.5 -5.3 118 139 A S T 3< S+ 0 0 16 -4,-0.6 -95,-1.7 1,-0.2 16,-0.2 -0.328 74.1 39.9 -66.1 149.5 -0.6 5.7 -5.2 119 140 A G T 3 S+ 0 0 0 14,-3.3 -94,-0.4 -97,-0.2 -1,-0.2 0.327 94.1 110.0 91.2 -9.5 -3.5 4.0 -7.0 120 141 A G < - 0 0 0 -3,-1.4 2,-0.3 13,-0.2 -95,-0.3 0.222 68.0-105.7 -77.2-151.5 -3.3 6.7 -9.8 121 142 A P - 0 0 0 0, 0.0 2,-0.9 0, 0.0 -35,-0.5 -0.997 3.7-137.9-147.5 148.3 -2.1 5.8 -13.3 122 143 A L E - L 0 131C 0 9,-3.7 8,-1.4 -2,-0.3 9,-0.5 -0.836 34.4-157.6 -99.9 98.4 0.9 6.2 -15.6 123 144 A L E -HL 84 129C 24 -39,-2.6 -39,-0.5 -2,-0.9 6,-0.2 -0.640 13.6-122.5 -83.4 135.6 -0.7 7.0 -19.0 124 145 A C > - 0 0 4 4,-2.7 3,-1.2 -2,-0.4 -41,-0.1 -0.050 41.4 -93.4 -58.8 175.6 1.2 6.4 -22.2 125 146 A P T 3 S+ 0 0 80 0, 0.0 -1,-0.1 0, 0.0 -42,-0.1 0.584 127.3 54.4 -72.1 -5.0 1.6 9.5 -24.5 126 147 A S T 3 S- 0 0 85 2,-0.1 -2,-0.1 0, 0.0 -3,-0.0 0.448 125.8 -92.8-106.1 -0.2 -1.7 8.4 -26.3 127 148 A G S < S+ 0 0 33 -3,-1.2 -53,-0.9 1,-0.3 2,-0.6 0.805 78.1 140.6 94.7 33.8 -4.0 8.2 -23.2 128 149 A H B -f 74 0B 40 -55,-0.2 -4,-2.7 -4,-0.1 2,-0.5 -0.931 46.8-138.5-114.0 118.5 -3.5 4.5 -22.5 129 150 A A E +L 123 0C 3 -2,-0.6 -6,-0.2 -55,-0.5 3,-0.1 -0.611 39.7 149.6 -77.3 121.9 -3.3 3.4 -18.8 130 151 A V E + 0 0 16 -8,-1.4 21,-1.1 -2,-0.5 2,-0.3 0.413 60.1 38.3-130.0 -4.1 -0.6 0.8 -18.3 131 152 A G E -LM 122 150C 2 -9,-0.5 -9,-3.7 19,-0.2 2,-0.6 -0.942 55.8-157.7-152.8 131.1 0.7 1.4 -14.7 132 153 A I E - M 0 149C 2 17,-1.7 17,-3.1 -2,-0.3 -14,-0.1 -0.918 37.5-110.9-109.9 119.1 -0.9 2.3 -11.3 133 154 A F E + M 0 148C 2 -2,-0.6 -14,-3.3 15,-0.3 15,-0.3 -0.183 42.9 167.2 -50.0 129.3 1.5 3.9 -8.8 134 155 A R E + 0 0 95 13,-3.6 2,-0.3 1,-0.4 14,-0.2 0.652 60.1 2.5-117.2 -30.1 2.1 1.5 -5.9 135 156 A A E - M 0 147C 38 12,-1.9 12,-3.4 -18,-0.1 2,-0.4 -0.979 60.7-128.5-162.1 146.6 5.1 3.0 -4.0 136 157 A A E - M 0 146C 31 -2,-0.3 2,-1.2 10,-0.2 10,-0.2 -0.797 14.7-140.2-100.0 138.3 7.5 6.0 -4.1 137 158 A V E - 0 0 54 8,-2.5 7,-3.9 -2,-0.4 2,-0.6 -0.739 28.0-174.6 -95.7 91.0 11.3 5.6 -4.0 138 159 A C E + M 0 143C 65 -2,-1.2 5,-0.3 5,-0.3 -2,-0.0 -0.765 10.0 176.0 -94.0 122.2 12.3 8.5 -1.7 139 160 A T S S- 0 0 96 3,-2.3 -1,-0.1 -2,-0.6 4,-0.1 0.768 76.7 -6.0 -87.1-102.1 16.0 9.1 -1.3 140 161 A R S S- 0 0 240 1,-0.1 -2,-0.1 2,-0.1 3,-0.1 0.970 136.0 -48.9 -60.0 -50.0 17.0 12.2 0.9 141 162 A G S S+ 0 0 36 1,-0.2 -30,-0.4 -32,-0.0 -29,-0.3 0.141 121.2 75.3-176.2 30.5 13.3 13.2 1.2 142 163 A V S S- 0 0 43 -32,-0.3 -3,-2.3 -31,-0.1 2,-0.4 -0.993 83.4-102.3-149.8 145.9 11.9 13.1 -2.4 143 164 A A E -KM 109 138C 0 -34,-2.5 -34,-0.6 -2,-0.3 -5,-0.3 -0.572 29.9-179.5 -75.9 125.3 10.9 10.2 -4.6 144 165 A K E S+ 0 0 98 -7,-3.9 2,-0.3 -2,-0.4 -1,-0.1 0.316 72.5 16.3-103.9 7.1 13.5 9.5 -7.3 145 166 A A E S- 0 0 17 -8,-0.5 -8,-2.5 -41,-0.2 2,-0.5 -0.864 70.8-133.8-175.3 137.9 11.5 6.7 -8.9 146 167 A V E -JM 103 136C 0 -43,-3.5 -43,-3.0 -2,-0.3 2,-0.3 -0.860 11.1-155.5-105.8 134.7 7.9 5.4 -8.9 147 168 A D E +JM 102 135C 47 -12,-3.4 -13,-3.6 -2,-0.5 -12,-1.9 -0.769 23.4 173.9-100.4 146.6 6.9 1.8 -8.4 148 169 A F E - M 0 133C 4 -47,-0.7 -15,-0.3 -15,-0.3 -30,-0.0 -0.987 33.8 -95.9-152.6 163.0 3.5 0.7 -9.8 149 170 A V E - M 0 132C 1 -17,-3.1 -17,-1.7 -2,-0.3 2,-0.3 -0.550 42.4-117.2 -79.8 143.8 1.2 -2.3 -10.4 150 171 A P E >> - M 0 131C 27 0, 0.0 3,-0.8 0, 0.0 4,-0.5 -0.597 6.0-141.4 -83.8 141.5 1.2 -3.9 -13.9 151 172 A V H >> S+ 0 0 8 -21,-1.1 4,-1.4 -2,-0.3 3,-1.2 0.823 100.6 70.3 -69.1 -27.7 -2.0 -3.8 -16.0 152 173 A E H 3> S+ 0 0 88 1,-0.3 4,-0.9 -22,-0.2 -1,-0.2 0.855 93.0 58.4 -59.1 -28.7 -1.2 -7.3 -17.2 153 174 A S H <> S+ 0 0 12 -3,-0.8 4,-0.9 1,-0.2 -1,-0.3 0.812 99.1 58.0 -70.7 -26.3 -2.1 -8.3 -13.7 154 175 A M H