==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=27-NOV-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER IMMUNE SYSTEM 18-MAY-00 1E27 . COMPND 2 MOLECULE: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN HEAVY . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR K.MAENAKA,T.MAENAKA,H.TOMIYAMA,M.TAKIGUCHI,D.I.STUART, . 384 3 3 3 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 19362.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 250 65.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 135 35.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 4 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 6 1.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 21 5.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 30 7.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 58 15.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 4 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 2 6 3 2 0 4 0 3 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 2 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A G 0 0 65 0, 0.0 103,-0.1 0, 0.0 102,-0.0 0.000 360.0 360.0 360.0 42.3 23.2 15.4 30.1 2 2 A S + 0 0 66 1,-0.1 2,-0.3 100,-0.0 102,-0.2 0.846 360.0 175.4 64.8 111.8 19.5 16.1 30.0 3 3 A H E -A 103 0A 25 100,-2.0 100,-3.4 26,-0.1 2,-0.3 -0.898 11.5-159.6-139.0 166.1 18.4 19.5 28.7 4 4 A S E -A 102 0A 4 -2,-0.3 25,-2.7 98,-0.2 2,-0.4 -0.999 12.2-147.7-152.1 149.7 15.2 21.3 27.9 5 5 A M E -AB 101 28A 0 96,-1.8 96,-1.9 -2,-0.3 2,-0.3 -0.961 25.9-177.0-115.4 137.3 13.8 24.2 25.9 6 6 A R E -AB 100 27A 68 21,-2.6 21,-3.1 -2,-0.4 2,-0.4 -0.991 17.8-160.1-139.2 145.6 10.9 26.1 27.3 7 7 A Y E -AB 99 26A 2 92,-2.1 92,-2.1 -2,-0.3 2,-0.5 -0.988 9.4-162.8-124.1 133.4 8.7 28.9 26.2 8 8 A F E -AB 98 25A 26 17,-2.6 17,-1.6 -2,-0.4 2,-0.4 -0.975 5.7-169.2-121.3 119.2 6.6 30.9 28.7 9 9 A Y E -AB 97 24A 0 88,-2.8 88,-2.2 -2,-0.5 2,-0.4 -0.883 4.9-177.4-110.2 138.3 3.7 33.1 27.6 10 10 A T E -AB 96 23A 2 13,-2.4 13,-2.9 -2,-0.4 2,-0.4 -0.997 1.5-178.4-135.8 128.2 1.9 35.6 29.7 11 11 A A E -AB 95 22A 2 84,-2.4 84,-2.6 -2,-0.4 2,-0.4 -0.998 6.6-174.1-127.1 129.7 -1.2 37.7 28.5 12 12 A M E -AB 94 21A 18 9,-2.3 9,-2.0 -2,-0.4 82,-0.2 -0.978 15.3-143.3-132.5 124.3 -2.8 40.2 30.8 13 13 A S - 0 0 16 80,-2.4 6,-0.1 -2,-0.4 62,-0.0 -0.460 14.9-178.4 -79.8 156.3 -6.0 42.3 30.3 14 14 A R > - 0 0 40 4,-0.4 3,-2.6 78,-0.1 78,-0.1 -0.487 19.2-147.0-156.7 73.0 -6.1 45.9 31.6 15 15 A P T 3 S+ 0 0 61 0, 0.0 4,-0.1 0, 0.0 77,-0.1 -0.142 85.2 16.4 -47.5 129.0 -9.5 47.4 30.9 16 16 A G T 3 S+ 0 0 88 2,-0.1 3,-0.1 1,-0.0 74,-0.0 0.310 114.8 78.1 87.9 -9.4 -9.3 51.2 30.2 17 17 A R S < S- 0 0 147 -3,-2.6 2,-0.1 1,-0.5 -1,-0.0 -0.116 105.0 -85.8-124.6 37.8 -5.5 50.9 29.6 18 18 A G - 0 0 53 2,-0.0 -1,-0.5 3,-0.0 -4,-0.4 -0.321 69.9 -29.2 93.0-177.4 -5.3 49.5 26.1 19 19 A E S S- 0 0 107 1,-0.2 -7,-0.1 -6,-0.1 56,-0.0 -0.320 83.8 -74.7 -72.3 157.7 -5.4 46.0 24.6 20 20 A P - 0 0 15 0, 0.0 2,-0.3 0, 0.0 -7,-0.2 -0.248 49.5-122.0 -56.4 136.8 -4.1 43.0 26.6 21 21 A R E -B 12 0A 80 -9,-2.0 -9,-2.3 -3,-0.1 2,-0.4 -0.618 23.6-161.4 -81.7 138.9 -0.3 42.8 26.9 22 22 A F E -B 11 0A 2 -2,-0.3 16,-2.7 -11,-0.2 2,-0.4 -0.989 9.6-179.6-123.8 127.3 1.4 39.7 25.6 23 23 A I E -BC 10 37A 11 -13,-2.9 -13,-2.4 -2,-0.4 2,-0.4 -0.994 2.4-174.5-129.6 134.8 4.9 38.7 26.7 24 24 A A E +BC 9 36A 1 12,-2.8 12,-2.2 -2,-0.4 2,-0.3 -0.982 3.2 179.1-130.5 139.7 6.9 35.7 25.6 25 25 A V E -BC 8 35A 1 -17,-1.6 -17,-2.6 -2,-0.4 2,-0.4 -0.994 12.3-151.9-137.6 145.1 10.3 34.4 26.8 26 26 A G E -BC 7 34A 0 8,-1.9 7,-2.7 -2,-0.3 8,-1.2 -0.935 13.1-174.8-120.3 143.2 12.3 31.4 25.7 27 27 A Y E -BC 6 32A 28 -21,-3.1 -21,-2.6 -2,-0.4 2,-0.5 -0.926 23.5-154.8-132.6 156.6 14.8 29.4 27.7 28 28 A V E > S-BC 5 31A 0 3,-2.0 3,-2.2 -2,-0.3 -23,-0.2 -0.985 81.6 -47.1-126.5 113.4 17.2 26.5 27.3 29 29 A D T 3 S- 0 0 23 -25,-2.7 -23,-0.1 -2,-0.5 -26,-0.1 -0.346 125.6 -21.3 54.6-128.3 17.6 25.1 30.8 30 30 A D T 3 S+ 0 0 59 -3,-0.1 2,-0.5 149,-0.1 -1,-0.3 0.079 118.4 97.7 -99.4 27.8 18.2 28.1 33.0 31 31 A T E < -C 28 0A 24 -3,-2.2 -3,-2.0 148,-0.0 2,-0.2 -0.940 64.0-146.0-119.1 113.9 19.4 30.4 30.2 32 32 A Q E +C 27 0A 30 -2,-0.5 -5,-0.3 -5,-0.2 3,-0.1 -0.547 23.7 168.9 -74.7 138.1 17.0 32.9 28.7 33 33 A F E + 0 0 0 -7,-2.7 15,-2.9 1,-0.3 16,-0.8 0.599 55.5 26.9-125.6 -17.1 17.7 33.4 25.0 34 34 A V E -CD 26 47A 1 -8,-1.2 -8,-1.9 13,-0.3 2,-0.3 -0.973 52.5-174.8-145.6 161.1 14.7 35.3 23.5 35 35 A R E -CD 25 46A 61 11,-1.5 11,-2.7 -2,-0.3 2,-0.3 -0.987 4.6-172.2-152.9 153.2 11.9 37.7 24.4 36 36 A F E -C 24 0A 1 -12,-2.2 -12,-2.8 -2,-0.3 2,-0.4 -0.966 4.5-177.6-148.8 134.5 8.9 39.3 22.8 37 37 A D E > -C 23 0A 36 -2,-0.3 3,-1.7 7,-0.3 -14,-0.2 -0.973 21.0-155.0-138.6 118.2 6.7 42.1 24.3 38 38 A S T 3 S+ 0 0 21 -16,-2.7 -15,-0.1 -2,-0.4 -1,-0.1 0.686 96.4 63.1 -66.2 -15.3 3.6 43.5 22.6 39 39 A D T 3 S+ 0 0 68 -17,-0.3 -1,-0.3 3,-0.1 -16,-0.1 0.504 77.3 112.9 -86.6 -6.9 4.2 46.7 24.6 40 40 A A S < S- 0 0 39 -3,-1.7 -4,-0.0 1,-0.1 0, 0.0 -0.339 82.5-110.9 -66.4 148.9 7.6 47.5 23.0 41 41 A A S S+ 0 0 117 1,-0.3 -1,-0.1 2,-0.0 -3,-0.0 0.886 114.8 14.4 -45.1 -50.0 7.8 50.6 20.7 42 42 A S S S- 0 0 87 2,-0.1 -1,-0.3 0, 0.0 -3,-0.1 -0.753 95.3-134.8-130.8 84.0 8.3 48.3 17.7 43 43 A P + 0 0 35 0, 0.0 2,-0.3 0, 0.0 -5,-0.1 -0.121 46.3 139.8 -44.3 115.3 7.3 44.8 18.8 44 44 A R - 0 0 146 -7,-0.2 -7,-0.3 -9,-0.1 2,-0.2 -0.973 58.0 -95.2-157.4 148.9 9.8 42.3 17.5 45 45 A T - 0 0 5 15,-0.4 -9,-0.2 -2,-0.3 19,-0.1 -0.513 45.2-159.7 -69.8 134.3 11.5 39.2 19.0 46 46 A E E -D 35 0A 71 -11,-2.7 -11,-1.5 -2,-0.2 2,-0.1 -0.943 17.0-114.3-123.3 141.0 14.8 40.1 20.5 47 47 A P E +D 34 0A 55 0, 0.0 -13,-0.3 0, 0.0 -14,-0.1 -0.388 26.4 177.4 -68.3 143.3 17.9 38.0 21.4 48 48 A R + 0 0 97 -15,-2.9 -14,-0.2 1,-0.2 -16,-0.1 0.309 66.1 52.8-128.6 3.1 18.8 37.6 25.1 49 49 A A S >> S- 0 0 4 -16,-0.8 3,-0.8 1,-0.1 4,-0.7 -0.990 80.7-124.4-139.8 142.6 21.8 35.3 24.8 50 50 A P G >4 S+ 0 0 104 0, 0.0 3,-0.9 0, 0.0 4,-0.4 0.883 104.0 56.2 -53.3 -49.2 24.9 35.7 22.7 51 51 A W G >4 S+ 0 0 24 1,-0.2 3,-0.6 2,-0.2 4,-0.1 0.731 100.4 57.8 -61.4 -26.2 24.8 32.4 20.8 52 52 A I G X4 S+ 0 0 0 -3,-0.8 3,-2.4 1,-0.2 -1,-0.2 0.777 86.7 79.2 -76.3 -26.3 21.3 33.0 19.4 53 53 A E G << S+ 0 0 122 -3,-0.9 -1,-0.2 -4,-0.7 -2,-0.2 0.761 80.4 67.4 -52.2 -30.4 22.3 36.2 17.7 54 54 A Q G < S+ 0 0 109 -3,-0.6 -1,-0.3 -4,-0.4 -2,-0.1 0.576 75.2 111.3 -71.3 -7.1 23.9 34.3 14.8 55 55 A E S < S- 0 0 12 -3,-2.4 5,-0.1 1,-0.1 -3,-0.0 -0.385 74.6-107.5 -66.0 145.7 20.5 33.0 13.7 56 56 A G >> - 0 0 22 1,-0.1 4,-1.5 -2,-0.0 3,-0.7 -0.134 25.9-101.6 -72.0 168.3 19.4 34.5 10.3 57 57 A P H 3> S+ 0 0 81 0, 0.0 4,-2.5 0, 0.0 5,-0.3 0.755 119.3 65.7 -60.6 -23.7 16.6 37.1 9.7 58 58 A E H 3> S+ 0 0 139 2,-0.2 4,-2.0 1,-0.2 5,-0.2 0.928 101.7 48.3 -63.4 -44.2 14.3 34.3 8.6 59 59 A Y H <> S+ 0 0 11 -3,-0.7 4,-2.1 1,-0.2 -1,-0.2 0.932 113.4 46.8 -60.4 -48.3 14.4 32.9 12.1 60 60 A W H X S+ 0 0 33 -4,-1.5 4,-2.2 1,-0.2 -15,-0.4 0.881 113.6 45.5 -65.1 -41.5 13.6 36.3 13.7 61 61 A D H X S+ 0 0 112 -4,-2.5 4,-2.2 2,-0.2 -1,-0.2 0.845 112.0 52.5 -72.7 -31.6 10.8 37.3 11.4 62 62 A R H X S+ 0 0 96 -4,-2.0 4,-2.3 -5,-0.3 -2,-0.2 0.916 109.3 51.1 -67.1 -40.5 9.2 33.9 11.7 63 63 A N H X S+ 0 0 0 -4,-2.1 4,-2.7 1,-0.2 -2,-0.2 0.941 110.9 46.8 -59.8 -48.8 9.4 34.3 15.5 64 64 A T H X S+ 0 0 17 -4,-2.2 4,-2.2 1,-0.2 5,-0.2 0.864 110.3 53.4 -64.0 -35.7 7.7 37.7 15.3 65 65 A Q H X S+ 0 0 109 -4,-2.2 4,-1.8 2,-0.2 -1,-0.2 0.925 111.0 46.3 -64.2 -44.8 5.0 36.3 13.0 66 66 A I H X S+ 0 0 5 -4,-2.3 4,-2.7 1,-0.2 316,-0.3 0.939 114.2 47.7 -63.8 -46.7 4.3 33.6 15.5 67 67 A F H X S+ 0 0 1 -4,-2.7 4,-2.0 2,-0.2 -2,-0.2 0.826 109.1 51.8 -66.9 -32.8 4.2 35.9 18.5 68 68 A K H X S+ 0 0 95 -4,-2.2 4,-1.6 2,-0.2 -1,-0.2 0.900 112.6 47.2 -69.8 -37.8 2.0 38.5 16.8 69 69 A T H X S+ 0 0 61 -4,-1.8 4,-2.3 -5,-0.2 3,-0.2 0.944 111.9 49.9 -65.1 -47.4 -0.5 35.7 16.0 70 70 A N H X S+ 0 0 0 -4,-2.7 4,-2.3 1,-0.2 5,-0.2 0.853 104.3 60.3 -59.1 -35.3 -0.2 34.4 19.6 71 71 A T H X S+ 0 0 5 -4,-2.0 4,-1.2 1,-0.2 -1,-0.2 0.931 109.2 41.4 -59.6 -45.0 -0.8 38.0 20.8 72 72 A Q H X S+ 0 0 106 -4,-1.6 4,-1.7 -3,-0.2 -2,-0.2 0.888 111.8 55.4 -70.9 -38.2 -4.2 38.1 19.1 73 73 A T H X S+ 0 0 17 -4,-2.3 4,-2.1 1,-0.2 -2,-0.2 0.891 109.3 47.1 -61.9 -39.9 -5.1 34.5 20.1 74 74 A Y H X S+ 0 0 2 -4,-2.3 4,-2.0 2,-0.2 -1,-0.2 0.800 105.9 57.3 -73.8 -26.9 -4.6 35.2 23.7 75 75 A R H X S+ 0 0 36 -4,-1.2 4,-1.4 -5,-0.2 -1,-0.2 0.892 110.2 46.5 -68.2 -34.3 -6.6 38.4 23.6 76 76 A E H X S+ 0 0 45 -4,-1.7 4,-3.1 2,-0.2 -2,-0.2 0.900 108.4 54.8 -71.1 -42.3 -9.4 36.2 22.3 77 77 A N H X S+ 0 0 0 -4,-2.1 4,-2.3 1,-0.2 -2,-0.2 0.858 106.6 52.2 -59.4 -35.5 -8.7 33.7 25.1 78 78 A L H X S+ 0 0 8 -4,-2.0 4,-1.1 2,-0.2 -1,-0.2 0.889 112.1 45.0 -67.9 -38.6 -9.1 36.5 27.6 79 79 A R H X S+ 0 0 113 -4,-1.4 4,-1.1 2,-0.2 -2,-0.2 0.896 114.1 49.4 -70.2 -41.5 -12.5 37.4 26.1 80 80 A I H X S+ 0 0 0 -4,-3.1 4,-2.2 1,-0.2 3,-0.2 0.875 105.3 58.5 -65.7 -37.3 -13.6 33.8 26.0 81 81 A A H X S+ 0 0 0 -4,-2.3 4,-1.7 1,-0.2 -1,-0.2 0.845 98.0 59.0 -61.8 -36.2 -12.5 33.3 29.6 82 82 A L H <>S+ 0 0 29 -4,-1.1 5,-3.0 -3,-0.2 -1,-0.2 0.914 109.2 45.5 -59.4 -41.1 -14.9 36.0 30.8 83 83 A R H ><5S+ 0 0 148 -4,-1.1 3,-1.1 -3,-0.2 -2,-0.2 0.922 110.2 52.5 -67.3 -46.7 -17.8 34.0 29.3 84 84 A Y H 3<5S+ 0 0 51 -4,-2.2 -1,-0.2 1,-0.2 -2,-0.2 0.757 121.8 32.2 -61.6 -27.2 -16.6 30.6 30.7 85 85 A Y T 3<5S- 0 0 65 -4,-1.7 -1,-0.2 -5,-0.2 -2,-0.2 0.199 106.7-119.6-116.7 15.3 -16.4 32.1 34.2 86 86 A N T < 5 + 0 0 154 -3,-1.1 2,-0.2 1,-0.2 -3,-0.2 0.884 59.2 160.6 48.1 46.3 -19.3 34.6 33.9 87 87 A Q < - 0 0 63 -5,-3.0 -1,-0.2 -6,-0.2 2,-0.1 -0.668 40.0-107.0-101.8 157.0 -16.9 37.4 34.7 88 88 A S > - 0 0 78 -2,-0.2 3,-0.7 1,-0.1 -1,-0.1 -0.339 16.1-129.7 -75.5 156.6 -17.1 41.2 34.0 89 89 A E T 3 S+ 0 0 163 1,-0.2 -1,-0.1 -2,-0.1 -7,-0.0 0.423 100.3 74.8 -85.0 0.4 -15.2 43.1 31.4 90 90 A A T 3 S+ 0 0 80 2,-0.1 -1,-0.2 -76,-0.1 2,-0.2 0.641 82.2 80.7 -87.7 -16.7 -14.2 45.5 34.1 91 91 A G S < S- 0 0 30 -3,-0.7 2,-0.4 -77,-0.1 -77,-0.1 -0.550 77.1-119.5 -95.4 159.7 -11.6 43.3 35.7 92 92 A S - 0 0 63 -2,-0.2 2,-0.3 -78,-0.1 -78,-0.1 -0.786 35.8-179.4 -94.7 134.1 -8.0 42.5 34.9 93 93 A H - 0 0 24 -2,-0.4 -80,-2.4 2,-0.0 2,-0.4 -0.894 15.8-139.1-133.6 164.2 -7.1 38.8 34.2 94 94 A T E -A 12 0A 5 -2,-0.3 25,-3.3 -82,-0.2 2,-0.4 -0.966 7.2-168.0-130.5 139.6 -4.2 36.7 33.3 95 95 A W E -AE 11 118A 0 -84,-2.6 -84,-2.4 -2,-0.4 2,-0.4 -0.978 14.9-174.1-119.8 134.0 -3.5 33.7 31.0 96 96 A Q E -AE 10 117A 0 21,-2.5 21,-2.3 -2,-0.4 2,-0.3 -0.990 3.6-178.6-131.1 144.2 -0.2 31.8 31.4 97 97 A T E -AE 9 116A 0 -88,-2.2 -88,-2.8 -2,-0.4 2,-0.4 -1.000 9.4-165.5-144.4 139.8 1.2 29.0 29.2 98 98 A M E -AE 8 115A 23 17,-2.1 17,-2.0 -2,-0.3 2,-0.3 -0.972 7.2-179.1-124.9 136.9 4.3 26.9 29.3 99 99 A Y E +AE 7 114A 6 -92,-2.1 -92,-2.1 -2,-0.4 2,-0.3 -0.948 17.2 151.2-128.4 150.9 5.6 24.7 26.5 100 100 A G E -AE 6 113A 1 13,-1.8 13,-2.9 -2,-0.3 2,-0.4 -0.925 33.1-148.3-179.9 152.2 8.7 22.6 26.6 101 101 A a E -AE 5 112A 0 -96,-1.9 -96,-1.8 -2,-0.3 2,-0.4 -0.998 14.0-154.5-131.1 131.3 10.6 19.5 25.6 102 102 A D E -AE 4 111A 30 9,-3.0 8,-3.8 -2,-0.4 9,-1.5 -0.890 15.4-166.3-105.0 136.0 13.1 17.6 27.7 103 103 A V E -AE 3 109A 3 -100,-3.4 -100,-2.0 -2,-0.4 6,-0.2 -0.922 11.9-132.2-124.9 148.4 15.8 15.7 25.9 104 104 A G > - 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