==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 15-SEP-08 3EHX . COMPND 2 MOLECULE: MACROPHAGE METALLOELASTASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR V.CALDERONE . 158 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 8298.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 82 51.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 17 10.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 4 2.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 8 5.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 14 8.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 32 20.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 106 A G 0 0 104 0, 0.0 120,-0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 169.5 -8.2 12.9 -2.5 2 107 A P - 0 0 75 0, 0.0 2,-0.3 0, 0.0 81,-0.1 -0.227 360.0-174.6 -65.4 153.3 -6.9 14.4 -5.7 3 108 A V - 0 0 24 78,-0.1 2,-0.3 79,-0.0 117,-0.1 -0.912 38.5 -90.8-135.3 159.0 -8.5 13.7 -9.1 4 109 A W - 0 0 23 115,-0.3 5,-0.0 -2,-0.3 115,-0.0 -0.609 30.0-151.8 -69.5 133.3 -7.3 14.8 -12.5 5 110 A R S S+ 0 0 204 -2,-0.3 2,-0.3 2,-0.0 -1,-0.1 -0.071 71.5 62.5 -99.9 35.1 -8.9 18.2 -13.4 6 111 A K S S- 0 0 95 1,-0.1 -2,-0.1 0, 0.0 3,-0.0 -0.968 70.6-137.1-157.1 156.9 -8.9 17.6 -17.1 7 112 A H S S+ 0 0 111 -2,-0.3 36,-2.7 1,-0.1 2,-0.7 0.754 85.3 71.3 -98.2 -26.2 -10.5 15.2 -19.6 8 113 A Y E -a 43 0A 179 34,-0.2 2,-0.4 36,-0.1 36,-0.2 -0.832 64.6-179.7 -96.9 113.2 -7.6 14.4 -21.9 9 114 A I E -a 44 0A 1 34,-3.4 36,-2.3 -2,-0.7 2,-0.4 -0.878 10.4-153.7-114.7 137.6 -5.0 12.2 -20.1 10 115 A T E -a 45 0A 38 -2,-0.4 44,-2.4 34,-0.2 43,-0.7 -0.877 8.4-169.9-111.1 149.7 -1.8 10.9 -21.6 11 116 A Y E -ab 46 54A 7 34,-2.7 36,-3.2 -2,-0.4 2,-0.3 -0.912 4.8-164.7-131.1 165.3 0.2 7.9 -20.8 12 117 A R E - b 0 55A 70 42,-2.1 44,-3.2 -2,-0.3 2,-1.0 -0.983 19.9-136.0-147.0 131.2 3.6 6.6 -21.8 13 118 A I E - b 0 56A 14 34,-0.4 44,-0.2 -2,-0.3 3,-0.1 -0.783 17.3-166.5 -90.3 108.3 5.2 3.2 -21.4 14 119 A N - 0 0 86 42,-2.7 2,-0.3 -2,-1.0 43,-0.2 0.871 66.5 -14.8 -60.3 -43.0 8.7 3.9 -20.1 15 120 A N - 0 0 53 41,-0.7 2,-0.4 44,-0.0 -1,-0.2 -0.961 69.4-111.6-159.8 166.5 10.0 0.3 -20.8 16 121 A Y - 0 0 60 -2,-0.3 6,-0.1 -3,-0.1 41,-0.0 -0.895 23.1-119.4-116.4 136.2 8.8 -3.1 -21.6 17 122 A T > - 0 0 0 -2,-0.4 3,-1.0 1,-0.1 8,-0.1 -0.469 15.7-140.7 -62.3 137.5 8.8 -6.3 -19.6 18 123 A P T 3 S+ 0 0 101 0, 0.0 -1,-0.1 0, 0.0 4,-0.1 0.563 93.5 81.6 -72.8 -3.2 10.8 -9.1 -21.3 19 124 A D T 3 S+ 0 0 38 77,-0.1 2,-0.3 2,-0.1 -2,-0.0 0.667 96.2 35.7 -74.2 -23.5 8.0 -11.4 -20.0 20 125 A M S < S- 0 0 17 -3,-1.0 2,-0.2 79,-0.1 79,-0.1 -0.830 91.0 -90.1-128.7 162.8 5.6 -10.5 -22.9 21 126 A N > - 0 0 100 -2,-0.3 4,-2.0 1,-0.1 3,-0.4 -0.536 42.1-122.8 -62.4 142.6 5.4 -9.6 -26.5 22 127 A R H > S+ 0 0 145 1,-0.2 4,-2.3 2,-0.2 5,-0.2 0.903 111.5 50.9 -59.0 -43.8 5.7 -5.8 -27.0 23 128 A E H > S+ 0 0 142 1,-0.2 4,-2.1 2,-0.2 -1,-0.2 0.828 108.7 53.6 -68.0 -27.5 2.4 -5.5 -28.8 24 129 A D H > S+ 0 0 46 -3,-0.4 4,-2.5 2,-0.2 -1,-0.2 0.855 107.3 50.7 -73.5 -37.1 0.7 -7.5 -26.0 25 130 A V H X S+ 0 0 0 -4,-2.0 4,-2.2 2,-0.2 5,-0.3 0.965 111.8 48.4 -59.1 -49.7 2.1 -5.1 -23.4 26 131 A D H X S+ 0 0 49 -4,-2.3 4,-2.3 1,-0.2 -2,-0.2 0.920 114.8 45.7 -56.0 -44.6 0.7 -2.2 -25.5 27 132 A Y H X S+ 0 0 137 -4,-2.1 4,-3.0 1,-0.2 5,-0.3 0.906 109.0 52.5 -71.5 -43.6 -2.7 -3.9 -25.8 28 133 A A H X S+ 0 0 9 -4,-2.5 4,-1.7 2,-0.2 -1,-0.2 0.877 114.5 43.2 -56.5 -45.6 -3.0 -4.9 -22.1 29 134 A I H X S+ 0 0 1 -4,-2.2 4,-2.5 2,-0.2 5,-0.2 0.926 114.0 50.9 -71.1 -41.8 -2.4 -1.3 -20.9 30 135 A R H X S+ 0 0 139 -4,-2.3 4,-2.4 -5,-0.3 -2,-0.2 0.942 112.0 46.6 -56.8 -51.5 -4.6 0.2 -23.6 31 136 A K H X S+ 0 0 62 -4,-3.0 4,-1.8 1,-0.2 -1,-0.2 0.866 110.2 54.6 -59.9 -37.0 -7.5 -2.1 -22.7 32 137 A A H X S+ 0 0 0 -4,-1.7 4,-0.9 -5,-0.3 -1,-0.2 0.917 108.3 46.5 -66.9 -42.0 -6.9 -1.3 -19.0 33 138 A F H >X S+ 0 0 2 -4,-2.5 4,-2.3 1,-0.2 3,-0.8 0.936 108.2 59.4 -63.5 -39.9 -7.2 2.4 -19.6 34 139 A Q H 3X S+ 0 0 59 -4,-2.4 4,-2.0 1,-0.3 -2,-0.2 0.864 94.4 63.4 -56.5 -38.4 -10.3 1.7 -21.7 35 140 A V H 3< S+ 0 0 13 -4,-1.8 4,-0.3 1,-0.2 -1,-0.3 0.913 111.7 37.2 -51.2 -43.5 -12.1 0.0 -18.7 36 141 A W H X< S+ 0 0 0 -4,-0.9 3,-0.8 -3,-0.8 6,-0.3 0.809 112.9 53.6 -83.4 -34.2 -12.0 3.4 -16.9 37 142 A S H >< S+ 0 0 32 -4,-2.3 3,-0.8 1,-0.2 -1,-0.2 0.758 98.8 69.7 -69.7 -19.6 -12.7 5.6 -19.9 38 143 A N T 3< S+ 0 0 125 -4,-2.0 -1,-0.2 -5,-0.2 -2,-0.2 0.751 110.5 29.9 -63.9 -27.7 -15.8 3.4 -20.5 39 144 A V T < S+ 0 0 31 -3,-0.8 -1,-0.2 -4,-0.3 -2,-0.2 0.133 120.3 48.0-125.3 16.9 -17.5 4.8 -17.4 40 145 A T S < S- 0 0 21 -3,-0.8 114,-0.1 2,-0.2 118,-0.0 -0.886 85.5-105.7-141.7 176.8 -16.1 8.3 -17.1 41 146 A P S S+ 0 0 55 0, 0.0 -4,-0.1 0, 0.0 -3,-0.1 0.382 79.2 122.3 -83.4 5.2 -15.6 11.4 -19.4 42 147 A L - 0 0 2 -6,-0.3 2,-0.4 -34,-0.1 -2,-0.2 -0.350 46.7-160.3 -74.9 148.4 -11.8 10.7 -19.4 43 148 A K E -a 8 0A 128 -36,-2.7 -34,-3.4 2,-0.0 2,-0.4 -1.000 8.1-155.9-124.9 131.6 -9.9 10.1 -22.7 44 149 A F E -a 9 0A 31 -2,-0.4 2,-0.4 -36,-0.2 -34,-0.2 -0.907 10.5-176.4-115.1 133.8 -6.6 8.4 -22.6 45 150 A S E -a 10 0A 62 -36,-2.3 -34,-2.7 -2,-0.4 2,-0.4 -0.995 20.6-135.2-130.9 136.2 -3.8 8.7 -25.2 46 151 A K E -a 11 0A 77 -2,-0.4 2,-0.3 -36,-0.2 -34,-0.2 -0.670 22.9-172.7 -86.3 126.9 -0.5 7.0 -25.5 47 152 A I - 0 0 49 -36,-3.2 -34,-0.4 -2,-0.4 5,-0.1 -0.907 18.3-154.2-118.8 153.3 2.5 9.2 -26.4 48 153 A N S S+ 0 0 117 -2,-0.3 2,-0.3 -36,-0.1 -36,-0.1 0.375 74.5 31.9-109.2 0.8 6.0 7.9 -27.1 49 154 A T S S+ 0 0 109 2,-0.1 -1,-0.1 0, 0.0 2,-0.1 -0.992 94.6 24.1-155.3 156.8 7.9 10.9 -26.1 50 155 A G S S- 0 0 42 -2,-0.3 2,-0.5 -3,-0.1 -3,-0.1 -0.300 100.2 -31.9 82.8-169.2 8.0 13.8 -23.7 51 156 A M - 0 0 167 -2,-0.1 2,-0.2 4,-0.0 3,-0.1 -0.761 57.5-166.5 -95.6 124.8 6.2 13.8 -20.3 52 157 A A - 0 0 12 -2,-0.5 3,-0.2 1,-0.1 -41,-0.2 -0.578 29.1-123.5 -95.5 160.3 3.0 11.9 -20.0 53 158 A D S S+ 0 0 27 -43,-0.7 2,-0.7 1,-0.2 -42,-0.2 0.949 105.0 37.5 -63.9 -50.9 0.5 12.3 -17.1 54 159 A I E S-b 11 0A 0 -44,-2.4 -42,-2.1 35,-0.1 2,-0.5 -0.888 75.1-163.7-110.3 108.0 0.8 8.6 -16.3 55 160 A L E -b 12 0A 47 -2,-0.7 35,-2.5 -44,-0.2 2,-0.6 -0.814 9.5-150.4 -89.6 130.2 4.2 6.9 -16.7 56 161 A V E -bc 13 90A 1 -44,-3.2 -42,-2.7 -2,-0.5 -41,-0.7 -0.899 21.8-178.6-104.1 123.2 4.1 3.2 -16.9 57 162 A V E - c 0 91A 18 33,-2.7 35,-3.0 -2,-0.6 2,-0.5 -0.944 26.1-155.5-129.2 136.3 7.3 1.5 -15.6 58 163 A F E + c 0 92A 8 -2,-0.4 2,-0.3 33,-0.2 35,-0.2 -0.975 38.6 144.7-104.6 128.1 8.6 -2.0 -15.1 59 164 A A E - c 0 93A 19 33,-2.3 35,-2.7 -2,-0.5 36,-0.4 -0.955 33.6-142.4-156.4 159.6 11.2 -2.2 -12.3 60 165 A R - 0 0 136 -2,-0.3 33,-0.0 33,-0.2 -2,-0.0 -0.946 59.7 -16.1-129.8 158.4 12.4 -4.5 -9.6 61 166 A G S S+ 0 0 24 -2,-0.3 8,-2.4 7,-0.1 2,-0.3 -0.153 123.2 5.5 54.4-142.9 13.7 -4.0 -6.0 62 167 A A S S+ 0 0 93 6,-0.2 -2,-0.2 1,-0.1 4,-0.1 -0.553 70.1 169.8 -71.4 125.8 14.6 -0.4 -5.1 63 168 A H - 0 0 41 -2,-0.3 -1,-0.1 2,-0.2 3,-0.1 0.027 61.3 -77.5-137.8 32.5 13.7 1.7 -8.1 64 169 A G S S+ 0 0 84 1,-0.3 2,-0.2 2,-0.0 -2,-0.1 0.603 104.7 76.4 88.5 12.8 14.1 5.3 -7.1 65 170 A D S S- 0 0 35 0, 0.0 -1,-0.3 0, 0.0 -2,-0.2 -0.690 91.1 -96.8-132.7-163.7 10.9 5.9 -5.1 66 171 A D S S+ 0 0 154 -2,-0.2 -4,-0.0 1,-0.2 2,-0.0 0.084 103.8 76.8-105.7 28.2 9.8 4.9 -1.6 67 172 A H - 0 0 97 -6,-0.1 -1,-0.2 11,-0.0 -6,-0.0 -0.460 68.9-170.3-135.8 57.8 7.9 1.8 -2.6 68 173 A A - 0 0 60 -3,-0.2 -6,-0.2 1,-0.1 2,-0.1 -0.128 22.3-119.2 -49.5 143.6 10.6 -0.8 -3.2 69 174 A F - 0 0 12 -8,-2.4 -1,-0.1 1,-0.1 3,-0.1 -0.453 13.6-142.5 -84.0 167.6 9.5 -4.0 -4.7 70 175 A D - 0 0 84 1,-0.5 -1,-0.1 5,-0.3 -10,-0.0 -0.117 39.9-100.0-127.2 29.2 10.0 -7.3 -2.9 71 176 A G S S- 0 0 22 3,-0.1 -1,-0.5 25,-0.0 24,-0.1 -0.186 80.2 -9.5 75.3-172.5 11.0 -10.0 -5.5 72 177 A K S S+ 0 0 151 -3,-0.1 24,-0.2 23,-0.1 3,-0.1 -0.353 119.6 5.5 -63.4 135.7 8.6 -12.6 -6.9 73 178 A G S S+ 0 0 29 1,-0.2 2,-0.3 2,-0.1 -3,-0.3 -0.224 97.2 65.4 85.3-171.8 5.2 -12.6 -5.1 74 179 A G S S+ 0 0 69 -2,-0.1 2,-0.3 -5,-0.1 -1,-0.2 -0.467 105.2 29.0 62.4-122.0 3.9 -10.3 -2.4 75 180 A I + 0 0 86 -2,-0.3 -5,-0.3 1,-0.1 3,-0.1 -0.530 63.0 179.6 -73.6 130.6 3.6 -6.8 -4.0 76 181 A L - 0 0 31 1,-0.4 17,-2.5 -2,-0.3 2,-0.3 0.709 61.9 -24.1-101.5 -28.3 2.9 -7.0 -7.7 77 182 A A E -D 92 0A 9 15,-0.3 -1,-0.4 -19,-0.0 2,-0.3 -0.961 53.4-155.9-171.8 165.2 2.7 -3.3 -8.6 78 183 A H E -D 91 0A 24 13,-2.5 13,-3.1 -2,-0.3 2,-0.3 -0.966 6.6-161.8-156.1 162.9 1.9 0.1 -7.1 79 184 A A E -D 90 0A 21 -2,-0.3 2,-0.3 11,-0.2 11,-0.2 -0.990 16.6-123.4-148.7 152.9 0.7 3.5 -8.4 80 185 A F - 0 0 35 9,-2.7 8,-0.4 6,-0.3 3,-0.1 -0.723 31.9-110.5-101.0 145.2 0.7 7.1 -7.3 81 186 A G - 0 0 38 -2,-0.3 7,-1.2 1,-0.2 8,-0.2 -0.155 55.4 -62.3 -65.9 163.3 -2.4 9.2 -7.0 82 187 A P S S+ 0 0 11 0, 0.0 2,-0.3 0, 0.0 -1,-0.2 -0.094 86.2 89.0 -50.0 139.3 -3.2 12.1 -9.4 83 188 A G S S- 0 0 35 4,-0.2 -3,-0.0 35,-0.1 -79,-0.0 -0.885 72.0 -43.1 158.3 179.8 -0.8 15.0 -9.4 84 189 A S S > S- 0 0 116 -2,-0.3 3,-2.2 2,-0.1 2,-0.2 -0.191 99.2 -5.1 -67.3 160.1 2.4 16.5 -10.8 85 190 A G T 3 S+ 0 0 52 1,-0.3 -2,-0.1 3,-0.1 4,-0.1 -0.353 140.7 7.8 66.3-121.6 5.6 14.6 -11.5 86 191 A I T > S+ 0 0 98 -2,-0.2 3,-2.3 2,-0.1 -6,-0.3 0.627 102.5 119.7 -70.1 -11.8 5.5 11.0 -10.3 87 192 A G T < S+ 0 0 6 -3,-2.2 -4,-0.2 1,-0.3 -32,-0.2 -0.264 78.6 17.7 -51.0 136.2 1.8 11.6 -9.6 88 193 A G T 3 S+ 0 0 0 -7,-1.2 -1,-0.3 -8,-0.4 30,-0.1 0.168 93.4 140.2 89.4 -20.5 -0.3 9.2 -11.7 89 194 A D < - 0 0 11 -3,-2.3 -9,-2.7 -8,-0.2 2,-0.5 -0.280 38.3-154.8 -73.3 147.4 2.6 6.9 -12.3 90 195 A A E -cD 56 79A 1 -35,-2.5 -33,-2.7 -11,-0.2 2,-0.4 -0.982 7.0-166.3-128.0 120.5 2.2 3.2 -12.3 91 196 A H E -cD 57 78A 15 -13,-3.1 -13,-2.5 -2,-0.5 2,-0.4 -0.890 3.4-158.6-111.6 136.6 5.0 0.8 -11.5 92 197 A F E -cD 58 77A 1 -35,-3.0 -33,-2.3 -2,-0.4 2,-0.7 -0.958 25.5-115.7-119.7 132.4 5.0 -3.0 -12.1 93 198 A D E > -c 59 0A 0 -17,-2.5 3,-2.1 -2,-0.4 -33,-0.2 -0.525 17.0-158.5 -71.1 110.2 7.3 -5.4 -10.4 94 199 A E T 3 S+ 0 0 15 -35,-2.7 -34,-0.2 -2,-0.7 -1,-0.2 0.688 87.9 72.5 -61.6 -18.7 9.6 -7.1 -13.0 95 200 A D T 3 S+ 0 0 48 -36,-0.4 -1,-0.3 -24,-0.1 2,-0.2 0.570 86.8 79.8 -75.0 -7.3 10.2 -10.0 -10.5 96 201 A E S < S- 0 0 9 -3,-2.1 2,-0.7 -20,-0.2 -77,-0.1 -0.581 90.7-119.3 -85.5 163.4 6.7 -11.0 -11.3 97 202 A F - 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