==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=27-NOV-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER CYTOKINE 11-JAN-99 1ERN . COMPND 2 MOLECULE: PROTEIN (ERYTHROPOIETIN RECEPTOR); . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR O.LIVNAH,E.A.STURA,I.A.WILSON . 416 7 4 4 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 21170.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 238 57.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 8 1.9 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 138 33.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 4 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 38 9.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 30 7.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 13 3.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 1 5 4 3 5 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 4 5 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 10 A K 0 0 237 0, 0.0 3,-0.5 0, 0.0 4,-0.3 0.000 360.0 360.0 360.0 -73.5 8.9 1.8 -25.4 2 11 A F > + 0 0 30 1,-0.2 4,-2.5 2,-0.2 5,-0.3 0.298 360.0 99.1 -96.6 6.4 5.7 0.5 -23.8 3 12 A E H > S+ 0 0 82 1,-0.2 4,-0.9 2,-0.2 -1,-0.2 0.791 86.1 46.5 -62.5 -27.1 5.0 -1.4 -27.0 4 13 A S H > S+ 0 0 64 -3,-0.5 4,-2.7 2,-0.2 -1,-0.2 0.852 109.1 51.8 -83.6 -39.7 6.5 -4.4 -25.2 5 14 A K H > S+ 0 0 10 -4,-0.3 4,-4.5 2,-0.2 5,-0.3 0.960 112.2 45.8 -61.6 -50.7 4.6 -4.0 -22.0 6 15 A A H X S+ 0 0 0 -4,-2.5 4,-1.1 1,-0.2 -1,-0.2 0.881 111.1 53.8 -59.8 -40.0 1.2 -3.7 -23.8 7 16 A A H >< S+ 0 0 52 -4,-0.9 3,-0.6 -5,-0.3 -1,-0.2 0.965 115.8 39.0 -59.7 -49.5 2.2 -6.7 -25.9 8 17 A L H 3< S+ 0 0 93 -4,-2.7 3,-0.4 1,-0.2 -2,-0.2 0.955 114.0 53.2 -65.0 -49.7 2.9 -8.7 -22.7 9 18 A L H 3< S+ 0 0 14 -4,-4.5 2,-0.7 1,-0.3 -1,-0.2 0.638 78.3 99.3 -61.7 -12.5 -0.1 -7.3 -20.8 10 19 A A << 0 0 26 -4,-1.1 -1,-0.3 -3,-0.6 -2,-0.1 0.233 360.0 360.0 -62.0 21.8 -2.3 -8.3 -23.7 11 20 A A 0 0 102 -2,-0.7 -2,-0.1 -3,-0.4 -3,-0.0 0.066 360.0 360.0 -97.6 360.0 -3.1 -11.3 -21.5 12 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 13 24 A E 0 0 125 0, 0.0 17,-0.4 0, 0.0 3,-0.1 0.000 360.0 360.0 360.0 -59.0 -8.8 -7.6 -25.8 14 25 A E - 0 0 118 1,-0.1 2,-0.6 15,-0.1 16,-0.3 0.010 360.0 -78.8 -72.4-176.1 -10.3 -6.0 -22.8 15 26 A L - 0 0 3 14,-0.1 2,-0.4 12,-0.1 14,-0.2 -0.825 57.5-164.3 -90.1 122.5 -9.3 -2.5 -21.5 16 27 A L E -A 28 0A 14 12,-2.9 12,-1.9 -2,-0.6 2,-0.3 -0.940 11.4-176.4-119.3 134.1 -6.0 -2.9 -19.8 17 28 A a E +A 27 0A 4 -2,-0.4 2,-0.3 10,-0.2 10,-0.2 -0.876 6.7 165.3-125.5 157.2 -4.2 -0.6 -17.4 18 29 A F E -A 26 0A 1 8,-1.5 8,-2.3 -2,-0.3 2,-0.4 -0.969 24.9-136.8-165.3 154.0 -0.9 -0.6 -15.5 19 30 A T B -d 108 0B 0 88,-2.0 90,-2.2 -2,-0.3 6,-0.1 -0.936 4.2-160.6-118.2 142.9 1.4 1.8 -13.6 20 31 A E S S+ 0 0 47 -2,-0.4 91,-0.3 88,-0.2 -1,-0.1 0.847 90.2 3.5 -91.2 -40.6 5.1 1.8 -14.1 21 32 A R S S- 0 0 51 89,-0.1 329,-0.1 116,-0.1 -1,-0.1 -0.012 102.8 -99.2-140.5 37.2 6.2 3.6 -10.9 22 33 A L S S+ 0 0 2 82,-0.2 83,-0.1 2,-0.2 3,-0.1 0.644 112.1 77.8 56.0 23.3 3.0 4.1 -8.9 23 34 A E S S+ 0 0 54 81,-0.1 2,-0.3 57,-0.1 56,-0.2 -0.116 93.0 45.7-146.1 35.9 2.6 7.8 -10.0 24 35 A D - 0 0 32 54,-0.1 2,-0.3 80,-0.1 -2,-0.2 -0.968 59.9-152.9-168.2 167.4 1.2 7.1 -13.5 25 36 A L - 0 0 1 49,-0.3 49,-1.6 -2,-0.3 2,-0.4 -0.919 3.4-169.7-160.5 131.8 -1.4 5.0 -15.4 26 37 A V E -AB 18 73A 20 -8,-2.3 -8,-1.5 -2,-0.3 2,-0.4 -0.991 8.2-177.3-126.0 128.0 -1.6 3.7 -18.9 27 38 A a E +AB 17 72A 0 45,-1.9 45,-2.1 -2,-0.4 2,-0.3 -0.947 11.6 157.3-124.1 143.5 -4.8 2.2 -20.3 28 39 A F E -AB 16 71A 1 -12,-1.9 -12,-2.9 -2,-0.4 2,-0.3 -0.973 18.7-163.6-158.1 166.9 -5.2 0.7 -23.8 29 40 A W E - B 0 70A 1 41,-1.4 41,-2.2 -2,-0.3 2,-0.4 -0.949 14.2-136.0-151.5 163.0 -7.3 -1.7 -25.8 30 41 A E E + B 0 69A 33 -17,-0.4 2,-0.3 -16,-0.3 39,-0.2 -0.959 25.2 157.3-130.7 145.8 -6.9 -3.5 -29.1 31 42 A E E - B 0 68A 37 37,-1.7 37,-3.2 -2,-0.4 3,-0.1 -0.974 49.9 -68.8-158.4 160.9 -9.3 -4.1 -32.0 32 43 A A E - B 0 67A 80 -2,-0.3 35,-0.2 35,-0.2 2,-0.2 -0.223 58.3-104.4 -55.2 140.7 -9.1 -4.9 -35.7 33 44 A A - 0 0 67 33,-0.7 2,-0.4 1,-0.0 -1,-0.1 -0.472 43.2-166.6 -66.9 136.3 -7.9 -2.0 -37.8 34 45 A S > - 0 0 76 3,-0.3 3,-2.5 -2,-0.2 -1,-0.0 -0.988 26.8 -98.9-136.2 131.0 -10.8 -0.4 -39.6 35 46 A A T 3 S+ 0 0 101 -2,-0.4 3,-0.1 1,-0.3 0, 0.0 -0.069 105.3 3.4 -43.4 128.1 -10.8 2.1 -42.5 36 47 A G T 3 S+ 0 0 79 1,-0.2 2,-0.6 0, 0.0 -1,-0.3 0.349 98.1 124.2 76.0 -7.2 -11.3 5.6 -41.4 37 48 A V < + 0 0 43 -3,-2.5 -3,-0.3 2,-0.0 -1,-0.2 -0.785 29.1 145.1 -94.9 118.5 -11.3 4.8 -37.7 38 49 A G > - 0 0 13 -2,-0.6 3,-2.8 -3,-0.1 4,-0.1 -0.746 67.1 -71.0-135.0-176.0 -8.8 6.6 -35.6 39 50 A P G > S+ 0 0 51 0, 0.0 3,-0.6 0, 0.0 19,-0.3 0.558 124.1 68.4 -57.7 -9.2 -8.4 8.1 -32.1 40 51 A G G 3 S+ 0 0 68 1,-0.2 -3,-0.0 3,-0.1 19,-0.0 0.567 89.5 63.4 -86.8 -10.2 -10.9 10.8 -33.1 41 52 A N G < S+ 0 0 66 -3,-2.8 51,-3.2 50,-0.0 2,-0.4 0.300 99.8 63.1 -95.3 8.2 -13.6 8.2 -33.2 42 53 A Y E < -F 91 0C 29 -3,-0.6 2,-0.5 49,-0.3 16,-0.2 -0.994 62.6-150.6-138.7 141.9 -13.4 7.4 -29.5 43 54 A S E -F 90 0C 47 47,-2.5 47,-1.8 -2,-0.4 2,-0.6 -0.938 9.2-168.3-110.5 125.7 -14.0 9.2 -26.2 44 55 A F E +F 89 0C 2 -2,-0.5 12,-3.3 12,-0.5 2,-0.3 -0.967 17.7 174.8-112.2 112.1 -11.9 8.1 -23.2 45 56 A S E +FG 88 55C 7 43,-1.9 43,-2.3 -2,-0.6 2,-0.3 -0.818 6.2 169.1-117.8 160.9 -13.3 9.6 -20.0 46 57 A Y E -FG 87 54C 7 8,-2.2 8,-2.6 -2,-0.3 2,-0.3 -0.978 12.9-154.0-161.9 160.7 -12.5 9.2 -16.3 47 58 A Q E -F 86 0C 46 39,-1.2 39,-1.5 -2,-0.3 2,-0.2 -0.994 7.5-146.1-151.4 145.0 -13.1 10.7 -13.0 48 59 A L > - 0 0 28 -2,-0.3 3,-0.7 1,-0.2 37,-0.1 -0.619 62.8 -52.4 -99.2 162.3 -11.6 11.1 -9.5 49 60 A E T 3 S- 0 0 157 35,-0.3 -1,-0.2 1,-0.2 34,-0.0 -0.051 122.3 -18.3 -39.3 118.0 -13.7 11.2 -6.3 50 61 A D T 3 S+ 0 0 149 1,-0.2 -1,-0.2 -3,-0.1 -3,-0.0 0.927 105.2 125.8 38.5 73.7 -16.3 14.0 -6.8 51 62 A E S < S- 0 0 98 -3,-0.7 -1,-0.2 3,-0.0 3,-0.1 -0.946 70.4 -95.7-152.8 134.1 -14.5 15.6 -9.7 52 63 A P - 0 0 92 0, 0.0 -4,-0.2 0, 0.0 -6,-0.1 -0.328 50.9 -94.5 -60.1 134.6 -16.2 16.2 -13.1 53 64 A W - 0 0 87 -6,-0.1 2,-0.3 -8,-0.1 -6,-0.2 -0.095 47.2-163.0 -44.7 145.1 -15.5 13.5 -15.7 54 65 A K E -G 46 0C 110 -8,-2.6 -8,-2.2 -3,-0.1 2,-0.3 -0.903 13.3-121.8-132.2 158.5 -12.6 14.5 -17.9 55 66 A L E -G 45 0C 112 -2,-0.3 2,-0.4 -10,-0.2 -10,-0.3 -0.783 17.6-137.8-104.7 147.7 -11.4 13.1 -21.2 56 67 A b - 0 0 11 -12,-3.3 2,-0.9 -2,-0.3 -12,-0.5 -0.906 26.0-110.1-108.5 135.3 -8.1 11.6 -22.0 57 68 A R - 0 0 202 -2,-0.4 16,-0.4 16,-0.2 -14,-0.1 -0.442 42.6-143.7 -60.2 96.1 -6.1 12.4 -25.2 58 69 A L - 0 0 18 -2,-0.9 2,-0.3 -19,-0.3 14,-0.2 -0.147 15.7-164.4 -66.4 158.7 -6.3 9.1 -27.1 59 70 A H E -C 71 0A 48 12,-1.2 12,-1.9 -21,-0.0 2,-0.4 -0.985 6.9-150.2-141.7 147.8 -3.5 7.6 -29.3 60 71 A Q E +C 70 0A 78 -2,-0.3 10,-0.2 10,-0.2 8,-0.0 -0.947 18.6 171.3-122.5 142.9 -3.5 4.9 -31.9 61 72 A A E -C 69 0A 15 8,-1.9 8,-2.7 -2,-0.4 -2,-0.0 -0.997 31.2-109.0-149.9 148.8 -0.5 2.6 -32.7 62 73 A P - 0 0 102 0, 0.0 2,-0.3 0, 0.0 6,-0.1 -0.137 31.0-143.1 -69.3 173.7 0.1 -0.4 -34.9 63 74 A T > - 0 0 23 4,-0.3 3,-1.8 1,-0.0 -60,-0.0 -0.986 25.2-116.9-141.9 149.3 0.8 -3.9 -33.4 64 75 A A T 3 S+ 0 0 109 -2,-0.3 -1,-0.0 1,-0.3 -57,-0.0 0.679 116.0 51.6 -57.7 -15.9 3.0 -6.8 -34.3 65 76 A R T 3 S- 0 0 224 2,-0.2 -1,-0.3 0, 0.0 3,-0.1 0.454 115.4-104.8-104.3 -2.4 -0.3 -8.7 -34.8 66 77 A G S < S+ 0 0 60 -3,-1.8 -33,-0.7 1,-0.4 2,-0.2 0.291 85.9 105.5 100.6 -14.7 -2.4 -6.5 -37.1 67 78 A A E -B 32 0A 26 -35,-0.2 -1,-0.4 -5,-0.0 2,-0.3 -0.538 68.5-117.8 -93.4 166.3 -4.9 -5.1 -34.7 68 79 A V E -B 31 0A 18 -37,-3.2 -37,-1.7 -2,-0.2 2,-0.5 -0.798 16.0-141.0-108.9 153.7 -4.6 -1.5 -33.5 69 80 A R E -BC 30 61A 4 -8,-2.7 -8,-1.9 -2,-0.3 2,-0.5 -0.937 8.1-165.0-117.1 129.2 -4.0 -0.1 -30.0 70 81 A F E +BC 29 60A 1 -41,-2.2 -41,-1.4 -2,-0.5 2,-0.3 -0.950 20.0 178.6-110.0 127.3 -5.6 2.9 -28.6 71 82 A W E -BC 28 59A 67 -12,-1.9 -12,-1.2 -2,-0.5 2,-0.4 -0.930 20.5-162.3-132.9 158.4 -4.0 4.3 -25.4 72 83 A b E -B 27 0A 0 -45,-2.1 -45,-1.9 -2,-0.3 2,-0.6 -0.998 7.6-156.7-137.7 134.7 -4.3 7.1 -23.0 73 84 A S E -B 26 0A 65 -16,-0.4 -16,-0.2 -2,-0.4 -47,-0.2 -0.954 28.7-128.0-114.9 106.3 -1.7 8.3 -20.6 74 85 A L - 0 0 7 -49,-1.6 -49,-0.3 -2,-0.6 5,-0.1 -0.212 31.5 -97.0 -55.6 139.8 -3.5 10.0 -17.7 75 86 A P > - 0 0 61 0, 0.0 3,-2.2 0, 0.0 4,-0.2 -0.370 37.7-112.0 -59.5 139.8 -2.2 13.5 -16.9 76 87 A T G > S+ 0 0 106 1,-0.3 3,-0.8 2,-0.2 -2,-0.1 0.666 111.7 66.6 -47.7 -22.2 0.3 13.3 -14.0 77 88 A A G 3 S+ 0 0 55 1,-0.2 3,-0.5 2,-0.1 -1,-0.3 0.746 98.3 49.0 -75.4 -25.5 -2.1 15.2 -11.7 78 89 A D G < S+ 0 0 31 -3,-2.2 -1,-0.2 1,-0.2 -2,-0.2 0.192 109.4 53.9 -99.3 16.8 -4.8 12.5 -11.6 79 90 A T S < S+ 0 0 1 -3,-0.8 -1,-0.2 -4,-0.2 -2,-0.1 -0.041 75.3 97.2-137.5 30.6 -2.4 9.7 -10.8 80 91 A S S S+ 0 0 10 -3,-0.5 2,-0.3 272,-0.1 321,-0.1 0.148 86.8 34.3-107.5 18.8 -0.6 11.0 -7.8 81 92 A S S S- 0 0 28 2,-0.1 23,-0.2 322,-0.1 272,-0.0 -0.942 85.5-108.4-157.7 169.7 -2.7 9.2 -5.2 82 93 A F + 0 0 5 -2,-0.3 23,-0.1 21,-0.1 3,-0.1 0.061 62.9 139.1 -99.0 27.5 -4.4 5.8 -4.9 83 94 A V - 0 0 47 1,-0.1 21,-0.4 20,-0.1 -2,-0.1 -0.427 65.9 -92.6 -67.3 142.9 -8.0 7.0 -5.2 84 95 A P - 0 0 62 0, 0.0 2,-0.5 0, 0.0 -35,-0.3 -0.278 37.3-144.6 -59.6 140.7 -10.1 4.8 -7.4 85 96 A L E - 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