==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=21-JUN-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 07-NOV-05 2EX2 . COMPND 2 MOLECULE: PENICILLIN-BINDING PROTEIN 4; . SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; . AUTHOR H.KISHIDA,S.UNZAI,D.I.ROPER,A.LLOYD,S.-Y.PARK,J.R.H.TAME . 456 1 2 2 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 20166.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 325 71.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 29 6.4 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 73 16.0 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 41 9.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 52 11.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 107 23.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 7 1.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 2 0 0 0 0 0 1 1 2 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 1 1 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 4 0 2 0 0 4 0 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 1 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 22 A N > 0 0 122 0, 0.0 4,-2.1 0, 0.0 3,-0.3 0.000 360.0 360.0 360.0 47.0 69.9 -25.7 44.2 2 23 A V H > + 0 0 21 1,-0.2 4,-2.2 2,-0.2 3,-0.1 0.910 360.0 52.2 -57.3 -50.8 72.0 -23.3 46.3 3 24 A D H > S+ 0 0 106 1,-0.2 4,-0.8 2,-0.2 -1,-0.2 0.874 110.4 49.0 -55.4 -40.0 73.6 -25.9 48.5 4 25 A E H >4 S+ 0 0 104 -3,-0.3 3,-0.8 1,-0.2 4,-0.3 0.896 108.8 52.0 -68.5 -37.2 74.7 -27.9 45.5 5 26 A Y H >< S+ 0 0 16 -4,-2.1 3,-2.0 1,-0.2 4,-0.4 0.863 99.7 65.1 -66.3 -33.9 76.2 -24.9 43.8 6 27 A I H >< S+ 0 0 34 -4,-2.2 3,-1.6 1,-0.3 -1,-0.2 0.812 87.8 68.5 -57.2 -30.4 78.1 -24.1 47.0 7 28 A T T << S+ 0 0 105 -4,-0.8 -1,-0.3 -3,-0.8 -2,-0.2 0.719 92.0 61.2 -63.5 -19.6 80.1 -27.4 46.4 8 29 A Q T < S+ 0 0 61 -3,-2.0 -1,-0.3 -4,-0.3 -2,-0.2 0.741 94.1 82.6 -71.4 -25.2 81.6 -25.6 43.4 9 30 A L S < S- 0 0 13 -3,-1.6 3,-0.2 -4,-0.4 4,-0.1 -0.398 95.6 -86.1 -84.4 157.3 83.1 -23.0 45.8 10 31 A P > - 0 0 18 0, 0.0 3,-1.8 0, 0.0 -1,-0.2 -0.104 65.9 -67.7 -58.8 161.5 86.3 -23.5 47.8 11 32 A A T 3 S+ 0 0 103 1,-0.3 417,-0.2 417,-0.1 -4,-0.0 -0.248 118.7 3.9 -52.9 126.2 86.2 -25.3 51.1 12 33 A G T 3 S+ 0 0 63 1,-0.2 -1,-0.3 -3,-0.2 2,-0.0 0.582 82.3 161.9 80.1 12.4 84.4 -23.2 53.7 13 34 A A < - 0 0 14 -3,-1.8 2,-0.6 -7,-0.2 413,-0.2 -0.346 33.4-132.8 -68.8 148.2 83.2 -20.3 51.6 14 35 A N E -A 425 0A 100 411,-3.3 411,-2.6 2,-0.0 2,-0.4 -0.918 22.2-172.3-113.5 117.7 80.3 -18.4 53.1 15 36 A L E +A 424 0A 11 -2,-0.6 2,-0.4 409,-0.2 409,-0.2 -0.902 13.0 177.4-110.0 132.2 77.3 -17.4 51.0 16 37 A A E +A 423 0A 7 407,-2.5 407,-3.1 -2,-0.4 2,-0.4 -0.990 22.7 174.7-127.0 119.3 74.4 -15.1 52.0 17 38 A L E +AB 422 31A 0 14,-3.3 14,-3.0 -2,-0.4 2,-0.3 -0.984 17.7 176.6-136.5 137.5 71.9 -14.8 49.1 18 39 A M E -AB 421 30A 14 403,-2.2 403,-2.6 -2,-0.4 2,-0.4 -0.987 1.7-179.1-141.5 132.9 68.5 -13.2 48.5 19 40 A V E +AB 420 29A 0 10,-2.4 10,-2.1 -2,-0.3 9,-2.0 -1.000 13.7 167.7-131.5 132.7 66.5 -12.9 45.3 20 41 A Q E -A 419 0A 15 399,-2.5 399,-2.9 -2,-0.4 3,-0.1 -0.972 37.6-109.2-154.5 125.8 63.1 -11.1 45.2 21 42 A K E > -A 418 0A 111 5,-0.4 3,-1.7 -2,-0.3 397,-0.3 -0.202 51.2 -94.9 -50.1 139.2 60.7 -9.9 42.6 22 43 A V T 3 S+ 0 0 44 395,-2.7 -1,-0.1 1,-0.3 395,-0.1 -0.485 111.9 11.9 -60.7 126.9 60.6 -6.1 42.3 23 44 A G T 3 S+ 0 0 60 1,-0.3 -1,-0.3 -2,-0.2 2,-0.1 0.259 99.8 122.7 87.6 -10.3 57.8 -4.8 44.4 24 45 A A < - 0 0 35 -3,-1.7 -1,-0.3 1,-0.1 330,-0.0 -0.460 54.5-149.9 -79.0 156.1 57.2 -8.2 46.2 25 46 A S S S+ 0 0 123 -2,-0.1 -1,-0.1 -3,-0.1 -2,-0.0 0.716 79.6 59.2 -97.3 -26.1 57.4 -8.5 50.0 26 47 A A S S- 0 0 67 -5,-0.0 -5,-0.4 2,-0.0 2,-0.1 -0.868 83.4-121.6-107.3 138.8 58.6 -12.1 50.1 27 48 A P - 0 0 45 0, 0.0 -7,-0.3 0, 0.0 3,-0.1 -0.456 2.4-150.2 -74.7 148.3 61.8 -13.4 48.5 28 49 A A S S+ 0 0 58 -9,-2.0 2,-0.4 1,-0.3 -8,-0.2 0.803 93.1 29.0 -80.4 -38.2 62.0 -16.2 45.9 29 50 A I E +B 19 0A 31 -10,-2.1 -10,-2.4 2,-0.0 2,-0.3 -0.997 67.2 171.9-125.2 130.6 65.4 -17.3 47.2 30 51 A D E +B 18 0A 94 -2,-0.4 2,-0.5 -12,-0.2 -12,-0.2 -0.870 7.2 160.3-140.2 102.5 66.5 -16.8 50.8 31 52 A Y E S-B 17 0A 51 -14,-3.0 -14,-3.3 -2,-0.3 -2,-0.0 -0.922 85.2 -34.4-124.0 101.0 69.8 -18.4 51.9 32 53 A H S > S+ 0 0 96 -2,-0.5 3,-1.7 -16,-0.2 -14,-0.1 0.848 84.0 160.3 57.1 39.5 71.0 -16.7 55.1 33 54 A S T 3 + 0 0 4 1,-0.3 314,-2.8 -16,-0.2 315,-0.3 0.694 68.5 53.6 -70.7 -17.3 69.6 -13.4 53.8 34 55 A Q T 3 S+ 0 0 139 312,-0.2 -1,-0.3 311,-0.1 2,-0.2 0.499 84.7 109.9 -89.5 -8.2 69.6 -11.9 57.3 35 56 A Q S < S- 0 0 108 -3,-1.7 312,-0.1 1,-0.1 309,-0.1 -0.535 71.8-116.8 -78.2 136.0 73.3 -12.7 58.0 36 57 A M + 0 0 56 -2,-0.2 2,-0.3 309,-0.2 309,-0.2 -0.376 41.0 172.0 -69.0 144.9 75.8 -9.8 58.1 37 58 A A B -F 344 0B 9 307,-1.4 307,-2.3 -2,-0.1 387,-0.0 -0.978 42.5 -94.5-148.4 162.7 78.5 -9.6 55.5 38 59 A L - 0 0 27 -2,-0.3 305,-0.2 305,-0.2 386,-0.1 -0.687 33.8-162.3 -71.0 120.4 81.3 -7.5 54.1 39 60 A P > - 0 0 0 0, 0.0 3,-1.8 0, 0.0 -1,-0.1 0.717 15.1-175.8 -79.9 -21.3 79.7 -5.6 51.2 40 61 A A G > S- 0 0 1 1,-0.3 3,-2.2 299,-0.3 4,-0.2 -0.259 70.5 -10.7 52.8-144.9 82.9 -4.6 49.4 41 62 A S G > S+ 0 0 15 1,-0.3 3,-1.8 2,-0.2 4,-0.3 0.610 120.9 82.4 -65.7 -6.6 82.2 -2.4 46.4 42 63 A T G X> S+ 0 0 0 -3,-1.8 3,-1.8 1,-0.3 4,-0.7 0.775 75.3 76.2 -64.9 -17.8 78.5 -3.1 46.6 43 64 A Q H <> S+ 0 0 0 -3,-2.2 4,-2.0 1,-0.3 3,-0.3 0.800 79.2 72.1 -55.3 -26.3 78.6 -0.4 49.2 44 65 A K H <> S+ 0 0 0 -3,-1.8 4,-2.9 292,-0.4 -1,-0.3 0.762 86.0 64.0 -67.3 -22.8 78.8 2.0 46.2 45 66 A V H <> S+ 0 0 1 -3,-1.8 4,-2.1 -4,-0.3 -1,-0.2 0.945 106.4 42.9 -62.8 -49.2 75.1 1.3 45.5 46 67 A I H X S+ 0 0 0 -4,-0.7 4,-2.9 -3,-0.3 5,-0.3 0.914 113.5 51.9 -58.4 -43.7 74.2 2.9 48.8 47 68 A T H X S+ 0 0 0 -4,-2.0 4,-2.4 288,-0.3 -2,-0.2 0.930 109.8 49.1 -60.4 -47.0 76.6 5.7 48.3 48 69 A A H X S+ 0 0 0 -4,-2.9 4,-2.2 2,-0.2 -1,-0.2 0.886 113.7 46.4 -61.5 -42.4 75.2 6.5 44.8 49 70 A L H X S+ 0 0 0 -4,-2.1 4,-2.2 2,-0.2 -2,-0.2 0.968 114.5 45.5 -67.5 -48.5 71.6 6.5 46.2 50 71 A A H X S+ 0 0 0 -4,-2.9 4,-2.6 1,-0.2 5,-0.3 0.882 112.5 53.1 -62.9 -35.7 72.3 8.6 49.2 51 72 A A H X>S+ 0 0 0 -4,-2.4 4,-3.0 -5,-0.3 5,-1.3 0.926 108.8 48.4 -63.6 -46.6 74.3 11.1 47.0 52 73 A L H <5S+ 0 0 14 -4,-2.2 4,-0.3 3,-0.2 -1,-0.2 0.877 115.0 46.0 -63.4 -38.3 71.5 11.5 44.5 53 74 A I H <5S+ 0 0 47 -4,-2.2 -2,-0.2 -5,-0.2 -1,-0.2 0.913 123.7 31.9 -67.9 -44.9 69.0 12.1 47.4 54 75 A Q H <5S+ 0 0 49 -4,-2.6 -2,-0.2 -5,-0.2 -3,-0.2 0.916 136.4 19.2 -80.1 -46.7 71.3 14.6 49.3 55 76 A L T <5S- 0 0 29 -4,-3.0 -3,-0.2 -5,-0.3 3,-0.2 0.715 98.5-136.3 -99.1 -29.4 73.2 16.3 46.5 56 77 A G > < - 0 0 16 -5,-1.3 3,-1.4 -4,-0.3 218,-0.2 0.153 31.1 -76.7 80.3 160.6 71.1 15.7 43.4 57 78 A P T 3 S+ 0 0 60 0, 0.0 218,-2.4 0, 0.0 219,-0.4 0.674 127.0 53.7 -67.5 -17.5 72.2 14.6 39.9 58 79 A D T 3 S+ 0 0 129 215,-0.2 -2,-0.1 216,-0.2 -6,-0.0 0.414 75.8 124.5-101.0 0.8 73.4 18.1 38.9 59 80 A F < - 0 0 52 -3,-1.4 215,-2.2 214,-0.1 2,-0.4 -0.278 42.2-164.0 -58.5 142.2 75.7 18.7 41.9 60 81 A R - 0 0 103 213,-0.2 2,-0.2 214,-0.1 212,-0.1 -0.995 20.0-122.9-130.6 140.5 79.3 19.6 40.8 61 82 A F - 0 0 1 211,-0.4 210,-2.3 -2,-0.4 2,-0.4 -0.542 35.0-151.7 -71.4 150.9 82.5 19.5 42.7 62 83 A T E -G 270 0C 52 23,-0.3 2,-0.4 208,-0.2 208,-0.2 -0.981 21.1-176.9-134.0 139.0 84.2 23.0 42.7 63 84 A T E -G 269 0C 2 206,-2.3 206,-2.2 -2,-0.4 2,-0.3 -0.985 19.3-179.1-127.6 140.3 87.8 24.3 43.0 64 85 A T E -GH 268 83C 12 19,-1.9 19,-2.2 -2,-0.4 2,-0.5 -0.944 30.8-139.5-136.6 158.5 88.5 28.0 43.0 65 86 A L E -GH 267 82C 2 202,-2.5 201,-2.8 -2,-0.3 202,-1.4 -0.980 34.3-173.6-108.1 131.4 91.3 30.6 43.2 66 87 A E E -GH 265 81C 4 15,-2.8 15,-2.7 -2,-0.5 2,-0.5 -0.970 15.7-144.6-129.0 141.1 90.2 33.5 45.5 67 88 A T E -GH 264 80C 16 197,-2.2 197,-2.3 -2,-0.4 2,-0.5 -0.914 8.1-170.5-109.6 137.2 91.8 36.8 46.3 68 89 A K E + H 0 79C 64 11,-1.6 11,-0.9 -2,-0.5 2,-0.2 -0.964 63.3 30.3-118.3 101.6 91.6 38.4 49.7 69 90 A G E S- H 0 78C 42 -2,-0.5 2,-0.2 9,-0.2 9,-0.2 -0.605 90.9 -63.6 135.3 168.2 93.0 42.0 49.2 70 91 A N E - H 0 77C 120 7,-0.6 7,-3.4 -2,-0.2 2,-0.6 -0.623 38.3-133.9 -86.3 147.3 93.3 44.8 46.7 71 92 A V E - H 0 76C 69 5,-0.2 2,-0.5 -2,-0.2 5,-0.3 -0.911 26.2-177.2-102.6 113.4 95.3 44.5 43.4 72 93 A E E > - H 0 75C 109 3,-2.9 3,-1.4 -2,-0.6 -2,-0.0 -0.953 69.2 -20.4-120.2 116.5 97.6 47.5 42.9 73 94 A N T 3 S- 0 0 170 -2,-0.5 -1,-0.2 1,-0.3 3,-0.1 0.880 130.7 -48.1 51.9 42.8 99.7 47.8 39.7 74 95 A G T 3 S+ 0 0 11 1,-0.2 34,-3.0 -3,-0.1 35,-1.6 0.447 115.5 119.0 81.6 2.2 99.4 44.0 39.2 75 96 A V E < -Hi 72 109C 24 -3,-1.4 -3,-2.9 33,-0.2 2,-0.6 -0.893 59.2-142.0-106.2 118.6 100.3 43.3 42.8 76 97 A L E -Hi 71 110C 0 33,-3.0 35,-3.3 -2,-0.6 2,-1.4 -0.713 11.0-150.0 -75.6 118.9 97.8 41.5 45.0 77 98 A K E S+Hi 70 111C 86 -7,-3.4 -7,-0.6 -2,-0.6 2,-0.3 -0.678 72.6 17.1 -91.4 81.8 98.1 43.1 48.5 78 99 A G E S-H 69 0C 18 -2,-1.4 2,-0.3 33,-0.8 -9,-0.2 -0.981 102.0 -30.7 147.6-161.7 97.2 40.0 50.4 79 100 A D E -H 68 0C 49 -11,-0.9 -11,-1.6 -2,-0.3 2,-0.5 -0.640 35.7-138.2 -99.7 147.8 96.9 36.2 50.0 80 101 A L E -Hj 67 114C 0 33,-2.3 35,-3.2 -2,-0.3 2,-0.5 -0.912 25.3-158.8 -92.9 129.9 96.0 34.0 47.1 81 102 A V E -Hj 66 115C 0 -15,-2.7 -15,-2.8 -2,-0.5 2,-0.7 -0.950 11.8-163.7-111.7 124.0 93.7 31.2 48.3 82 103 A A E -Hj 65 116C 1 33,-3.3 35,-2.9 -2,-0.5 2,-0.9 -0.925 15.3-160.7-103.4 107.1 93.3 27.9 46.4 83 104 A R E -Hj 64 117C 48 -19,-2.2 -19,-1.9 -2,-0.7 2,-0.2 -0.797 4.2-158.4 -97.8 105.4 90.1 26.4 47.7 84 105 A F - 0 0 4 33,-2.7 36,-0.4 -2,-0.9 62,-0.2 -0.526 11.1-170.6 -82.0 152.1 90.0 22.7 47.0 85 106 A G - 0 0 4 60,-0.3 -23,-0.3 -2,-0.2 61,-0.1 0.105 50.3 -97.8-136.0 24.4 86.7 20.9 47.0 86 107 A A + 0 0 0 59,-2.3 60,-0.1 1,-0.2 210,-0.1 0.717 57.8 171.2 66.8 24.3 87.4 17.2 46.8 87 108 A D > - 0 0 3 58,-0.4 3,-1.2 1,-0.2 -1,-0.2 -0.535 21.8-159.6 -67.5 114.8 86.9 17.0 43.1 88 109 A P T 3 S+ 0 0 0 0, 0.0 62,-0.3 0, 0.0 -1,-0.2 0.596 86.6 52.6 -73.4 -8.1 88.1 13.5 42.2 89 110 A T T 3 S+ 0 0 37 60,-0.1 -2,-0.1 183,-0.1 59,-0.1 0.377 73.6 130.0-108.0 2.8 88.6 14.6 38.5 90 111 A L < - 0 0 2 -3,-1.2 59,-2.7 57,-0.1 60,-0.5 -0.315 40.3-160.6 -62.4 140.7 90.7 17.7 38.9 91 112 A K >> - 0 0 106 57,-0.2 4,-1.4 58,-0.1 3,-0.9 -0.796 34.0-108.0-122.8 162.5 93.8 17.6 36.6 92 113 A R H 3> S+ 0 0 70 -2,-0.3 4,-2.4 1,-0.3 3,-0.3 0.890 120.4 58.6 -51.4 -42.6 97.2 19.4 36.5 93 114 A Q H 3> S+ 0 0 112 1,-0.2 4,-2.6 2,-0.2 -1,-0.3 0.810 98.4 56.3 -60.8 -33.4 95.8 21.3 33.5 94 115 A D H <> S+ 0 0 16 -3,-0.9 4,-2.4 2,-0.2 -1,-0.2 0.895 108.6 47.0 -66.2 -41.7 92.9 22.7 35.5 95 116 A I H X S+ 0 0 3 -4,-1.4 4,-2.2 -3,-0.3 -2,-0.2 0.941 112.5 50.5 -60.3 -47.3 95.4 24.2 37.9 96 117 A R H X S+ 0 0 130 -4,-2.4 4,-2.3 1,-0.2 -2,-0.2 0.911 112.0 48.3 -56.0 -46.1 97.4 25.6 34.9 97 118 A N H X S+ 0 0 78 -4,-2.6 4,-2.1 2,-0.2 -1,-0.2 0.894 109.8 49.9 -64.6 -41.5 94.2 27.0 33.5 98 119 A M H X S+ 0 0 5 -4,-2.4 4,-2.0 1,-0.2 -1,-0.2 0.868 111.3 50.1 -66.8 -35.4 93.1 28.7 36.7 99 120 A V H X S+ 0 0 2 -4,-2.2 4,-2.8 2,-0.2 -2,-0.2 0.902 108.0 53.1 -65.7 -43.7 96.5 30.3 37.1 100 121 A A H X S+ 0 0 50 -4,-2.3 4,-2.5 1,-0.2 -2,-0.2 0.898 110.8 48.4 -55.3 -41.1 96.3 31.5 33.4 101 122 A T H X S+ 0 0 67 -4,-2.1 4,-1.7 2,-0.2 -1,-0.2 0.882 108.8 51.9 -67.1 -41.6 93.0 33.1 34.4 102 123 A L H <>S+ 0 0 0 -4,-2.0 5,-1.6 2,-0.2 4,-0.2 0.925 111.9 47.4 -59.9 -46.8 94.5 34.7 37.5 103 124 A K H ><5S+ 0 0 71 -4,-2.8 3,-2.2 1,-0.2 -2,-0.2 0.945 111.1 50.6 -56.3 -51.1 97.3 36.2 35.4 104 125 A K H 3<5S+ 0 0 192 -4,-2.5 -1,-0.2 1,-0.3 -2,-0.2 0.758 99.9 65.5 -64.1 -26.4 94.8 37.4 32.8 105 126 A S T 3<5S- 0 0 68 -4,-1.7 -1,-0.3 -3,-0.1 -2,-0.2 0.548 128.1 -94.3 -69.5 -11.4 92.8 39.0 35.5 106 127 A G T < 5S+ 0 0 33 -3,-2.2 2,-0.7 1,-0.3 -3,-0.2 0.467 81.7 133.2 110.4 6.2 95.7 41.4 36.2 107 128 A V < + 0 0 2 -5,-1.6 -1,-0.3 1,-0.2 -32,-0.2 -0.823 9.7 152.7 -96.1 115.8 97.7 39.6 38.9 108 129 A N + 0 0 73 -34,-3.0 140,-1.6 -2,-0.7 2,-0.3 0.491 68.5 25.0-108.5 -16.3 101.4 39.4 38.3 109 130 A Q E -ik 75 248C 82 -35,-1.6 -33,-3.0 138,-0.3 2,-0.6 -0.992 63.2-143.1-155.8 139.6 102.7 39.3 41.9 110 131 A I E -ik 76 249C 0 138,-3.0 140,-1.7 -2,-0.3 2,-1.4 -0.956 3.9-162.6-113.8 117.1 101.3 38.3 45.3 111 132 A D E S+i 77 0C 68 -35,-3.3 -33,-0.8 -2,-0.6 2,-0.3 -0.663 75.5 28.1 -94.0 76.4 102.4 40.4 48.3 112 133 A G S S- 0 0 13 -2,-1.4 139,-2.2 -35,-0.1 138,-0.3 -0.971 99.6 -43.7 161.9-163.3 101.4 37.7 50.7 113 134 A N - 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