==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=1-MAR-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER TRANSFERASE/TRANSFERASE INHIBITOR 04-JUN-12 4FGT . COMPND 2 MOLECULE: THYMIDYLATE SYNTHASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR A.TOCHOWICZ,J.FINER-MOORE,R.M.STROUD,M.P.COSTI . 271 3 1 0 1 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 13859.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 179 66.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 13 4.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 41 15.1 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 24 8.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 26 9.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 65 24.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 4 1.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 2 0 0 0 1 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 2 0 0 3 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 29 A G >> 0 0 57 0, 0.0 3,-2.2 0, 0.0 4,-0.5 0.000 360.0 360.0 360.0-146.7 19.0 -24.4 2.3 2 30 A E H 3> + 0 0 7 1,-0.3 4,-2.3 2,-0.2 3,-0.3 0.750 360.0 78.7 -63.8 -20.9 22.5 -22.9 2.8 3 31 A L H 3> S+ 0 0 127 1,-0.2 4,-2.5 2,-0.2 -1,-0.3 0.798 87.9 59.2 -60.0 -23.2 21.0 -20.6 5.6 4 32 A Q H <> S+ 0 0 63 -3,-2.2 4,-2.5 2,-0.2 -1,-0.2 0.950 104.7 46.8 -66.1 -50.7 21.2 -23.6 7.9 5 33 A Y H X S+ 0 0 0 -4,-0.5 4,-2.6 -3,-0.3 5,-0.2 0.935 115.0 47.7 -56.2 -46.9 24.9 -24.0 7.5 6 34 A L H X S+ 0 0 14 -4,-2.3 4,-2.6 1,-0.2 -2,-0.2 0.931 111.2 50.5 -63.0 -38.5 25.3 -20.2 8.0 7 35 A G H X S+ 0 0 36 -4,-2.5 4,-2.2 -5,-0.2 -1,-0.2 0.891 110.5 50.2 -64.2 -38.7 23.1 -20.3 11.1 8 36 A Q H X S+ 0 0 29 -4,-2.5 4,-2.2 2,-0.2 -1,-0.2 0.892 110.5 48.7 -63.3 -48.1 25.1 -23.2 12.5 9 37 A I H X S+ 0 0 2 -4,-2.6 4,-2.4 1,-0.2 -2,-0.2 0.956 112.2 49.1 -57.9 -46.8 28.4 -21.4 12.0 10 38 A Q H X S+ 0 0 80 -4,-2.6 4,-2.6 -5,-0.2 -2,-0.2 0.922 109.6 53.3 -57.7 -40.0 27.0 -18.4 13.6 11 39 A H H X S+ 0 0 92 -4,-2.2 4,-2.8 1,-0.2 5,-0.4 0.872 109.1 47.3 -65.6 -38.8 25.7 -20.5 16.6 12 40 A I H X S+ 0 0 0 -4,-2.2 4,-2.4 2,-0.2 -1,-0.2 0.909 110.5 52.5 -70.5 -37.6 29.1 -22.0 17.2 13 41 A L H < S+ 0 0 36 -4,-2.4 -2,-0.2 -5,-0.2 -1,-0.2 0.947 118.1 38.7 -60.1 -44.7 30.8 -18.5 17.1 14 42 A R H < S+ 0 0 188 -4,-2.6 -2,-0.2 -5,-0.2 -1,-0.2 0.822 136.2 13.5 -73.7 -38.5 28.3 -17.3 19.6 15 43 A C H < S+ 0 0 72 -4,-2.8 -3,-0.2 -5,-0.2 -2,-0.2 0.468 86.6 122.3-123.2 -12.7 28.0 -20.4 21.9 16 44 A G < - 0 0 17 -4,-2.4 2,-0.4 -5,-0.4 14,-0.2 -0.235 55.0-131.3 -51.6 145.4 30.8 -22.8 21.2 17 45 A V E -A 29 0A 105 12,-2.8 12,-2.2 1,-0.0 -1,-0.1 -0.831 25.2-105.3-103.6 140.4 33.1 -23.7 24.0 18 46 A R E +A 28 0A 147 -2,-0.4 2,-0.3 10,-0.2 10,-0.2 -0.379 53.5 159.2 -59.7 135.6 36.8 -23.6 23.6 19 47 A A E -A 27 0A 40 8,-2.1 8,-1.5 6,-0.1 2,-0.4 -0.917 33.9-127.8-161.2 139.3 38.2 -27.2 23.3 20 48 A D E -A 26 0A 92 -2,-0.3 6,-0.2 6,-0.2 5,-0.1 -0.765 18.4-133.5 -98.9 138.3 41.4 -28.6 21.9 21 49 A D > - 0 0 37 4,-2.0 3,-1.9 -2,-0.4 -1,-0.1 -0.193 45.5 -81.3 -73.4 179.5 41.5 -31.4 19.3 22 50 A R T 3 S+ 0 0 172 1,-0.3 -1,-0.1 2,-0.1 -2,-0.0 0.617 132.4 51.0 -62.9 -13.0 43.9 -34.4 19.7 23 51 A T T 3 S- 0 0 95 2,-0.1 -1,-0.3 3,-0.0 3,-0.1 0.538 118.5-109.6-100.3 -9.8 46.9 -32.3 18.3 24 52 A G < + 0 0 45 -3,-1.9 2,-0.2 1,-0.3 -2,-0.1 0.317 68.2 145.4 104.2 -5.3 46.2 -29.4 20.7 25 53 A T - 0 0 60 1,-0.1 -4,-2.0 -5,-0.1 -1,-0.3 -0.451 53.5-111.1 -73.1 131.9 44.9 -26.9 18.1 26 54 A G E +A 20 0A 13 -2,-0.2 190,-2.0 -6,-0.2 191,-0.3 -0.276 43.1 168.1 -69.8 145.6 42.2 -24.7 19.5 27 55 A T E -AB 19 215A 5 -8,-1.5 -8,-2.1 188,-0.3 2,-0.4 -0.946 35.7-126.7-140.5 166.3 38.6 -25.0 18.4 28 56 A L E -AB 18 214A 22 186,-2.7 186,-2.7 -2,-0.3 2,-0.3 -0.976 40.5-172.8-104.3 139.7 35.2 -23.8 19.3 29 57 A S E +AB 17 213A 22 -12,-2.2 -12,-2.8 -2,-0.4 2,-0.3 -0.942 21.6 176.4-140.1 142.3 32.8 -26.8 19.7 30 58 A V E - B 0 212A 23 182,-2.2 182,-3.3 -2,-0.3 2,-0.5 -0.890 28.3-123.2-127.1 170.7 29.1 -27.7 20.3 31 59 A F E S+ B 0 211A 169 -2,-0.3 180,-0.2 180,-0.2 179,-0.1 -0.967 70.8 19.7-122.6 126.1 27.4 -31.1 20.4 32 60 A G E + 0 0 48 178,-2.7 2,-0.3 -2,-0.5 178,-0.2 0.745 60.8 162.0 96.2 104.5 24.5 -32.3 18.2 33 61 A M E - B 0 209A 21 176,-1.7 176,-2.3 -3,-0.1 2,-0.3 -0.980 10.9-177.4-143.7 163.2 23.5 -30.6 14.9 34 62 A Q E + B 0 208A 109 -2,-0.3 2,-0.3 174,-0.2 174,-0.2 -0.949 2.6 179.2-158.6 143.0 21.5 -31.5 11.9 35 63 A A E - B 0 207A 5 172,-1.9 172,-2.9 -2,-0.3 2,-0.4 -0.979 16.1-144.9-140.4 158.8 20.6 -29.9 8.6 36 64 A R E - B 0 206A 123 -2,-0.3 2,-0.5 170,-0.2 170,-0.2 -0.976 10.8-168.2-129.3 128.1 18.5 -31.0 5.6 37 65 A Y E - B 0 205A 0 168,-2.9 168,-2.6 -2,-0.4 2,-0.2 -0.970 22.5-127.9-116.9 126.9 19.4 -30.1 1.9 38 66 A S E - B 0 204A 34 -2,-0.5 166,-0.2 166,-0.2 165,-0.1 -0.466 19.1-173.4 -70.5 140.8 16.9 -30.7 -0.8 39 67 A L + 0 0 0 164,-3.0 2,-1.0 -2,-0.2 3,-0.4 0.207 48.1 119.3-108.3 9.3 18.3 -32.8 -3.8 40 68 A R S S- 0 0 88 163,-0.4 3,-0.1 1,-0.3 163,-0.1 -0.711 99.7 -27.1 -91.7 102.3 15.1 -32.3 -5.9 41 69 A D S S+ 0 0 139 -2,-1.0 2,-0.3 1,-0.1 -1,-0.3 0.737 132.6 70.3 64.8 23.5 16.0 -30.4 -9.1 42 70 A E - 0 0 61 -3,-0.4 193,-0.3 193,-0.1 -1,-0.1 -0.974 68.6-140.3-161.4 164.2 18.9 -28.8 -7.3 43 71 A F - 0 0 0 191,-2.6 2,-2.1 -2,-0.3 -4,-0.1 -0.996 20.7-128.9-135.7 126.8 22.3 -29.8 -5.9 44 72 A P + 0 0 0 0, 0.0 2,-0.7 0, 0.0 144,-0.1 -0.393 47.9 147.0 -86.5 69.3 23.7 -28.4 -2.6 45 73 A L - 0 0 0 -2,-2.1 -2,-0.1 189,-0.1 137,-0.1 -0.909 57.7-114.6 -96.1 115.9 27.2 -27.2 -3.6 46 74 A L > - 0 0 0 -2,-0.7 5,-0.5 135,-0.3 3,-0.1 -0.165 26.9-163.8 -66.5 149.4 27.5 -24.2 -1.2 47 75 A T T 5S+ 0 0 0 184,-0.2 214,-3.2 1,-0.1 -1,-0.1 0.564 72.8 81.9-112.3 -10.6 27.6 -20.6 -2.8 48 76 A T T 5S+ 0 0 0 212,-0.2 2,-0.3 1,-0.1 -1,-0.1 0.537 113.3 11.0 -75.7 -3.7 28.9 -18.4 -0.0 49 77 A K T 5S- 0 0 14 212,-0.1 2,-0.5 -3,-0.1 214,-0.3 -0.911 96.7 -95.8-157.5 157.0 32.4 -19.6 -1.0 50 78 A R T 5 - 0 0 128 -2,-0.3 214,-0.4 211,-0.2 2,-0.3 -0.663 40.2-148.1 -78.2 122.0 33.5 -21.6 -4.1 51 79 A V < - 0 0 8 -2,-0.5 2,-2.0 -5,-0.5 3,-0.2 -0.744 24.6-110.1 -92.4 146.3 33.6 -25.3 -3.1 52 80 A F > + 0 0 101 -2,-0.3 4,-2.2 1,-0.2 3,-0.5 -0.427 44.4 173.1 -78.5 79.2 36.3 -27.4 -4.8 53 81 A W H > S+ 0 0 34 -2,-2.0 4,-2.8 1,-0.3 5,-0.3 0.865 74.2 56.3 -65.0 -34.8 33.7 -29.4 -6.9 54 82 A K H > S+ 0 0 89 1,-0.2 4,-2.4 2,-0.2 -1,-0.3 0.912 108.4 46.6 -64.8 -40.8 36.5 -31.2 -8.9 55 83 A G H > S+ 0 0 0 -3,-0.5 4,-2.9 2,-0.2 5,-0.3 0.920 113.0 51.6 -58.5 -45.1 38.2 -32.4 -5.7 56 84 A V H X S+ 0 0 0 -4,-2.2 4,-2.2 1,-0.2 5,-0.2 0.962 114.9 40.9 -58.5 -54.5 34.6 -33.6 -4.5 57 85 A L H X S+ 0 0 1 -4,-2.8 4,-2.2 1,-0.2 -1,-0.2 0.917 118.3 44.6 -63.9 -50.3 33.9 -35.5 -7.6 58 86 A E H X S+ 0 0 15 -4,-2.4 4,-1.9 -5,-0.3 -1,-0.2 0.883 113.7 50.0 -64.5 -39.0 37.4 -37.1 -8.1 59 87 A E H X S+ 0 0 12 -4,-2.9 4,-2.5 -5,-0.2 -1,-0.2 0.926 111.0 49.2 -68.6 -37.0 37.8 -38.0 -4.5 60 88 A L H X S+ 0 0 4 -4,-2.2 4,-2.6 -5,-0.3 -2,-0.2 0.931 110.6 49.9 -67.3 -42.4 34.3 -39.8 -4.4 61 89 A L H X S+ 0 0 19 -4,-2.2 4,-2.1 -5,-0.2 -1,-0.2 0.916 110.4 51.6 -60.8 -38.9 35.1 -41.7 -7.6 62 90 A W H X>S+ 0 0 4 -4,-1.9 5,-1.5 2,-0.2 4,-0.5 0.900 108.6 49.7 -63.7 -43.2 38.4 -42.7 -6.0 63 91 A F H ><5S+ 0 0 14 -4,-2.5 3,-1.5 1,-0.2 -2,-0.2 0.918 109.4 53.6 -54.0 -48.3 36.5 -44.0 -2.8 64 92 A I H 3<5S+ 0 0 4 -4,-2.6 -2,-0.2 1,-0.3 -1,-0.2 0.886 102.2 56.8 -59.9 -41.7 34.2 -45.9 -5.1 65 93 A K H 3<5S- 0 0 114 -4,-2.1 -1,-0.3 -5,-0.2 -2,-0.2 0.676 107.8-129.1 -53.4 -23.5 37.2 -47.6 -6.8 66 94 A G T <<5 + 0 0 9 -3,-1.5 -3,-0.2 -4,-0.5 -2,-0.1 0.690 49.0 168.2 74.9 17.5 38.2 -48.8 -3.3 67 95 A S < - 0 0 10 -5,-1.5 27,-0.3 1,-0.1 26,-0.2 -0.294 33.0-174.9 -69.9 144.8 41.7 -47.4 -4.0 68 96 A T + 0 0 6 38,-0.3 20,-3.0 25,-0.1 2,-0.7 0.161 56.9 106.5-119.1 15.0 44.3 -47.1 -1.2 69 97 A N B > -F 87 0B 12 18,-0.2 3,-1.0 1,-0.2 4,-0.4 -0.827 52.6-164.8-102.3 106.5 46.8 -45.3 -3.6 70 98 A A T >> S+ 0 0 23 16,-2.9 4,-2.5 -2,-0.7 3,-1.4 0.827 89.7 63.9 -55.1 -31.6 47.2 -41.6 -3.0 71 99 A K H 3> S+ 0 0 124 1,-0.3 4,-2.1 2,-0.2 -1,-0.3 0.884 92.8 61.7 -62.4 -38.5 48.9 -41.4 -6.4 72 100 A E H <4 S+ 0 0 73 -3,-1.0 -1,-0.3 1,-0.2 -2,-0.2 0.576 113.5 35.9 -64.2 -16.4 45.7 -42.5 -8.2 73 101 A L H X4 S+ 0 0 4 -3,-1.4 3,-2.4 -4,-0.4 5,-0.5 0.794 113.1 52.8-100.5 -50.1 43.9 -39.4 -6.8 74 102 A S H >X S+ 0 0 49 -4,-2.5 3,-2.1 1,-0.3 4,-1.0 0.863 100.9 63.5 -56.3 -38.0 46.6 -36.6 -6.9 75 103 A S T 3< S+ 0 0 91 -4,-2.1 -1,-0.3 1,-0.3 -3,-0.1 0.496 89.6 69.8 -65.8 -4.9 47.3 -37.3 -10.5 76 104 A K T <4 S- 0 0 92 -3,-2.4 -1,-0.3 2,-0.3 -2,-0.2 0.393 127.0 -96.8 -92.3 4.2 43.7 -36.2 -11.2 77 105 A G T <4 S+ 0 0 64 -3,-2.1 2,-0.4 1,-0.3 -2,-0.2 0.838 90.7 118.3 79.5 39.3 44.8 -32.6 -10.4 78 106 A V < - 0 0 4 -4,-1.0 -2,-0.3 -5,-0.5 -1,-0.3 -0.993 39.5-178.0-140.6 128.3 43.5 -32.9 -6.8 79 107 A K + 0 0 159 -2,-0.4 -1,-0.1 1,-0.1 -5,-0.1 0.952 45.0 114.3 -86.6 -56.9 45.4 -32.7 -3.4 80 108 A I 0 0 98 1,-0.3 -1,-0.1 -7,-0.1 -25,-0.0 0.122 360.0 360.0 10.9 -83.8 42.9 -33.3 -0.6 81 109 A W 0 0 134 -11,-0.1 -1,-0.3 -3,-0.1 -2,-0.1 0.431 360.0 360.0 -67.4 360.0 44.4 -36.6 0.8 82 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 83 126 A R 0 0 227 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 73.3 55.5 -48.7 4.6 84 127 A E > - 0 0 99 1,-0.2 3,-0.9 2,-0.0 2,-0.1 -0.047 360.0 -73.7 -78.7 172.1 55.8 -47.5 1.0 85 128 A E T 3 S+ 0 0 165 1,-0.2 -1,-0.2 -16,-0.0 -14,-0.1 -0.373 110.3 2.8 -69.1 135.4 55.0 -44.3 -0.9 86 129 A G T 3 S+ 0 0 12 1,-0.2 -16,-2.9 -2,-0.1 2,-0.7 0.263 89.6 131.7 74.9 -12.7 51.3 -43.4 -1.6 87 130 A D B < +F 69 0B 15 -3,-0.9 -1,-0.2 -18,-0.2 -18,-0.2 -0.639 30.7 179.6 -75.5 112.3 50.0 -46.4 0.3 88 131 A L - 0 0 49 -20,-3.0 -1,-0.2 -2,-0.7 -19,-0.1 0.465 31.9-131.0 -95.0 -0.8 47.3 -45.0 2.6 89 132 A G - 0 0 13 -21,-0.4 2,-3.0 1,-0.1 -1,-0.3 -0.292 65.0 -17.1 75.5-169.6 46.3 -48.2 4.3 90 133 A P S S+ 0 0 29 0, 0.0 -1,-0.1 0, 0.0 5,-0.1 -0.310 83.1 175.3 -73.6 70.9 42.6 -49.3 4.6 91 134 A V >> - 0 0 2 -2,-3.0 4,-1.8 -25,-0.1 3,-0.6 0.016 48.3 -78.4 -70.6-177.0 41.1 -45.8 4.0 92 135 A Y H 3> S+ 0 0 31 1,-0.3 4,-1.8 2,-0.2 5,-0.1 0.840 128.4 50.5 -61.8 -39.1 37.3 -45.1 3.7 93 136 A G H 3> S+ 0 0 1 -26,-0.2 4,-1.5 1,-0.2 -1,-0.3 0.858 106.9 52.4 -68.1 -39.0 36.9 -46.4 0.2 94 137 A F H <> S+ 0 0 6 -3,-0.6 4,-2.6 -27,-0.3 -1,-0.2 0.877 111.7 49.5 -60.7 -40.2 38.6 -49.7 0.9 95 138 A Q H X S+ 0 0 12 -4,-1.8 4,-0.5 1,-0.2 22,-0.4 0.833 106.6 55.1 -67.0 -32.1 36.2 -50.1 3.8 96 139 A W H < S+ 0 0 0 -4,-1.8 22,-1.7 -5,-0.2 21,-1.2 0.851 122.6 26.5 -68.1 -36.9 33.2 -49.3 1.6 97 140 A R H < S+ 0 0 18 -4,-1.5 -2,-0.2 19,-0.2 -1,-0.2 0.683 135.0 28.1-102.0 -20.4 34.1 -52.1 -0.9 98 141 A H H >< S- 0 0 36 -4,-2.6 3,-2.2 -5,-0.2 18,-0.2 -0.225 75.7-179.4-138.2 46.9 36.0 -54.6 1.3 99 142 A F B 3< S+G 115 0C 30 16,-2.5 16,-2.6 -4,-0.5 3,-0.1 -0.262 73.3 8.1 -60.2 121.1 34.6 -54.2 4.8 100 143 A G T 3 S+ 0 0 76 1,-0.3 -1,-0.3 14,-0.2 14,-0.2 0.330 91.8 132.6 92.6 -7.3 36.4 -56.5 7.2 101 144 A A < - 0 0 20 -3,-2.2 2,-0.4 12,-0.2 -1,-0.3 -0.474 65.8-107.1 -72.3 146.4 39.1 -57.8 4.8 102 145 A E - 0 0 168 -2,-0.1 2,-0.4 -3,-0.1 -1,-0.1 -0.654 34.9-129.6 -77.1 128.7 42.6 -57.9 6.2 103 146 A Y + 0 0 46 -2,-0.4 3,-0.1 1,-0.2 -1,-0.0 -0.642 43.2 149.7 -79.5 130.5 44.6 -55.1 4.6 104 147 A R - 0 0 130 -2,-0.4 2,-0.3 1,-0.3 -1,-0.2 0.621 57.5 -0.8-116.1 -72.9 48.0 -56.1 3.2 105 148 A D > - 0 0 57 1,-0.1 3,-1.2 -16,-0.0 -1,-0.3 -0.867 50.4-127.6-130.3 150.6 49.2 -54.0 0.2 106 149 A M T 3 S+ 0 0 34 -2,-0.3 -38,-0.3 1,-0.2 -37,-0.1 0.779 115.2 44.7 -65.8 -23.6 48.0 -51.1 -2.1 107 150 A E T 3 S+ 0 0 154 -39,-0.1 -1,-0.2 2,-0.1 2,-0.1 0.064 90.7 116.7-108.3 20.6 48.7 -53.3 -5.2 108 151 A S S < S- 0 0 36 -3,-1.2 2,-0.7 1,-0.0 -5,-0.0 -0.348 71.6-111.5 -82.3 169.7 47.1 -56.5 -3.8 109 152 A D + 0 0 118 1,-0.1 -2,-0.1 -2,-0.1 -3,-0.0 -0.877 34.3 173.3-108.3 102.9 44.0 -58.2 -5.3 110 153 A Y > + 0 0 17 -2,-0.7 3,-3.1 2,-0.1 -1,-0.1 0.371 22.1 154.0 -95.7 6.4 41.1 -57.8 -2.8 111 154 A S T 3 S- 0 0 94 1,-0.3 3,-0.1 -13,-0.0 -2,-0.1 0.010 74.4 -4.4 -34.5 123.1 38.6 -59.4 -5.3 112 155 A G T 3 S+ 0 0 87 1,-0.2 2,-0.4 0, 0.0 -1,-0.3 0.561 102.4 128.9 62.1 10.1 35.7 -60.9 -3.4 113 156 A Q < - 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