==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=19-AUG-2012 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE/HYDROLASE INHIBITOR 28-JUN-12 4FUI . COMPND 2 MOLECULE: UROKINASE-TYPE PLASMINOGEN ACTIVATOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR Y.N.KANG,J.A.STUCKEY,V.NIENABER,V.GIRANDA . 246 1 5 5 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 11722.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 154 62.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 2 0.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 82 33.3 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 3 1.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 4 1.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 16 6.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 31 12.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 10 4.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 2 2 3 4 1 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A I 0 0 0 0, 0.0 2,-0.4 0, 0.0 192,-0.2 0.000 360.0 360.0 360.0 121.2 -13.1 -15.5 0.5 2 2 A I B -A 192 0A 12 190,-2.4 190,-1.4 143,-0.0 142,-0.1 -0.714 360.0 -21.6 -82.9 131.2 -12.6 -18.7 -1.5 3 3 A G S S+ 0 0 32 140,-0.6 188,-0.1 -2,-0.4 153,-0.1 -0.349 95.7 102.6 65.3-145.5 -15.7 -19.4 -3.7 4 4 A G S S- 0 0 41 154,-0.1 2,-0.3 151,-0.1 153,-0.2 -0.396 74.0 -75.3 68.5-144.7 -18.9 -17.7 -2.6 5 5 A E E -B 156 0B 121 151,-2.6 151,-2.1 -2,-0.1 2,-0.0 -0.992 33.9 -96.5-152.2 157.8 -20.0 -14.7 -4.5 6 6 A F E +B 155 0B 102 -2,-0.3 149,-0.3 149,-0.2 2,-0.2 -0.368 47.6 169.8 -71.3 152.3 -19.4 -10.9 -5.1 7 7 A T - 0 0 12 147,-2.5 2,-0.3 57,-0.2 147,-0.2 -0.796 26.4-119.3-147.4-174.5 -21.7 -8.6 -3.1 8 8 A T >> - 0 0 54 -2,-0.2 3,-1.5 145,-0.1 4,-0.5 -0.896 34.0-102.8-131.5 164.6 -22.1 -4.9 -2.2 9 9 A I G >4 S+ 0 0 2 -2,-0.3 3,-0.8 1,-0.3 6,-0.2 0.754 113.4 71.6 -62.6 -25.9 -22.1 -3.0 1.2 10 10 A E G 34 S+ 0 0 105 1,-0.2 -1,-0.3 2,-0.1 107,-0.0 0.820 99.7 49.2 -63.3 -22.1 -25.9 -2.7 1.2 11 11 A N G <4 S+ 0 0 93 -3,-1.5 -1,-0.2 1,-0.2 -2,-0.2 0.728 125.3 27.2 -82.8 -25.7 -26.0 -6.5 1.9 12 12 A Q S X< S+ 0 0 3 -3,-0.8 3,-1.9 -4,-0.5 -1,-0.2 -0.593 71.5 163.5-132.0 63.8 -23.4 -6.2 4.8 13 13 A P T 3 S+ 0 0 5 0, 0.0 105,-1.4 0, 0.0 49,-0.3 0.643 73.0 61.0 -70.4 -11.6 -23.9 -2.6 6.1 14 14 A W T 3 S+ 0 0 19 103,-0.2 21,-2.5 105,-0.1 2,-0.3 0.491 79.5 116.5 -82.2 -10.2 -22.0 -3.4 9.4 15 15 A F E < -J 34 0C 1 -3,-1.9 47,-0.5 -6,-0.2 2,-0.4 -0.473 49.9-160.4 -72.5 127.2 -18.8 -4.2 7.4 16 16 A A E -JK 33 61C 0 17,-2.7 17,-1.1 -2,-0.3 2,-0.6 -0.900 8.7-146.8-108.7 131.3 -15.8 -2.0 8.1 17 17 A A E -JK 32 60C 1 43,-2.2 43,-2.2 -2,-0.4 2,-0.5 -0.895 17.5-159.8 -98.0 114.1 -12.9 -1.7 5.6 18 18 A I E +JK 31 59C 0 13,-2.3 12,-3.2 -2,-0.6 13,-1.3 -0.880 13.6 175.6-106.8 123.7 -9.6 -1.1 7.6 19 19 A Y E -JK 29 58C 10 39,-2.9 39,-2.5 -2,-0.5 2,-0.4 -0.814 19.9-136.9-118.9 161.5 -6.5 0.4 5.8 20 20 A R E -JK 28 57C 35 8,-2.7 8,-2.1 -2,-0.3 2,-0.5 -0.975 9.7-139.2-125.8 135.5 -3.0 1.5 6.9 21 21 A R E -J 27 0C 86 35,-3.3 6,-0.2 -2,-0.4 2,-0.2 -0.802 24.0-155.7 -91.3 122.8 -1.1 4.6 5.8 22 22 A H > - 0 0 54 4,-3.5 3,-2.0 -2,-0.5 2,-0.1 -0.595 32.6 -82.3 -94.5 161.9 2.6 3.9 5.2 23 23 A R T 3 S+ 0 0 107 1,-0.3 3,-0.3 -2,-0.2 -1,-0.1 -0.415 121.0 35.1 -61.3 130.6 5.6 6.4 5.4 24 24 A G T 3 S- 0 0 93 1,-0.2 -1,-0.3 -2,-0.1 -3,-0.0 0.280 128.6 -81.6 102.3 -10.1 5.7 8.2 2.0 25 25 A G S < S+ 0 0 52 -3,-2.0 -1,-0.2 1,-0.3 -2,-0.1 0.220 81.4 139.6 103.4 -12.4 1.9 8.2 1.7 26 26 A S - 0 0 69 -3,-0.3 -4,-3.5 -5,-0.1 2,-0.4 -0.419 35.4-155.4 -69.9 142.0 0.9 4.8 0.3 27 27 A V E -J 21 0C 70 -6,-0.2 2,-0.3 -2,-0.1 -6,-0.2 -0.974 12.4-177.0-119.2 130.0 -2.3 3.2 1.8 28 28 A T E -J 20 0C 63 -8,-2.1 -8,-2.7 -2,-0.4 2,-0.1 -0.954 32.2-102.1-128.6 150.1 -2.9 -0.6 1.8 29 29 A Y E +J 19 0C 25 -2,-0.3 -10,-0.3 -10,-0.2 3,-0.1 -0.426 38.1 172.3 -68.3 139.0 -5.8 -2.8 2.9 30 30 A V E - 0 0 26 -12,-3.2 2,-0.3 1,-0.4 -11,-0.2 0.791 49.1 -36.5-111.0 -63.7 -5.3 -4.5 6.3 31 31 A a E -J 18 0C 7 -13,-1.3 -13,-2.3 166,-0.1 -1,-0.4 -0.950 51.6 -99.6-157.8 170.9 -8.4 -6.3 7.7 32 32 A G E +J 17 0C 1 166,-2.2 12,-0.4 -2,-0.3 2,-0.3 -0.419 35.4 179.8 -92.2 172.8 -12.2 -6.3 8.0 33 33 A G E -J 16 0C 0 -17,-1.1 -17,-2.7 -2,-0.1 2,-0.4 -0.945 21.5-121.1-163.2 171.8 -14.2 -5.2 11.0 34 34 A S E -JL 15 42C 0 8,-2.1 8,-2.6 -2,-0.3 2,-0.7 -0.995 18.1-128.4-131.6 135.6 -17.7 -4.8 12.2 35 35 A L E + L 0 41C 3 -21,-2.5 85,-1.9 -2,-0.4 6,-0.2 -0.705 30.7 169.2 -80.0 112.9 -19.6 -1.7 13.5 36 36 A I E S- 0 0 23 4,-2.1 -1,-0.2 -2,-0.7 5,-0.2 0.618 72.2 -1.7-100.3 -15.2 -21.1 -2.7 16.9 37 37 A S E > S- L 0 40C 39 3,-1.2 3,-1.5 81,-0.1 -1,-0.3 -0.928 89.0 -89.3-162.3 161.8 -22.2 1.0 17.8 38 38 A P T 3 S+ 0 0 59 0, 0.0 73,-2.4 0, 0.0 65,-0.0 0.793 127.2 34.3 -50.7 -36.8 -21.8 4.4 16.1 39 39 A b T 3 S+ 0 0 35 71,-0.2 64,-2.1 1,-0.1 2,-0.4 0.438 111.2 75.6 -97.0 -4.2 -18.3 5.1 17.7 40 40 A W E < -LM 37 102C 22 -3,-1.5 -4,-2.1 62,-0.2 -3,-1.2 -0.944 45.9-179.3-128.8 132.0 -17.0 1.4 17.8 41 41 A V E -LM 35 101C 0 60,-2.3 60,-3.1 -2,-0.4 2,-0.4 -0.945 17.6-151.8-115.6 132.1 -15.6 -1.1 15.3 42 42 A I E +LM 34 100C 0 -8,-2.6 -8,-2.1 -2,-0.4 58,-0.2 -0.902 30.5 142.4-108.2 137.2 -14.6 -4.6 16.5 43 43 A S E - M 0 99C 0 56,-2.9 56,-2.2 -2,-0.4 2,-0.4 -0.580 50.5 -65.0-147.4-156.3 -11.8 -6.6 14.7 44 44 A A > - 0 0 0 -12,-0.4 3,-1.3 54,-0.3 4,-0.3 -0.933 27.7-140.2-112.7 134.7 -8.9 -9.0 15.4 45 45 A T G >> S+ 0 0 0 -2,-0.4 3,-2.1 1,-0.2 4,-1.8 0.838 99.2 68.4 -59.4 -36.3 -5.7 -7.9 17.4 46 46 A H G 34 S+ 0 0 46 1,-0.3 4,-0.3 2,-0.2 -1,-0.2 0.739 91.1 64.3 -59.3 -20.7 -3.4 -9.9 15.0 47 47 A a G <4 S+ 0 0 17 -3,-1.3 -1,-0.3 1,-0.2 -2,-0.2 0.716 119.4 20.3 -68.2 -28.8 -4.3 -7.3 12.3 48 48 A F T X4 S+ 0 0 0 -3,-2.1 3,-1.3 -4,-0.3 -2,-0.2 0.503 91.4 99.9-122.0 -15.1 -2.6 -4.4 14.4 49 49 A I T 3< S+ 0 0 67 -4,-1.8 -3,-0.1 1,-0.3 -2,-0.1 0.767 89.1 45.9 -51.4 -35.1 -0.2 -6.1 16.9 50 50 A D T 3 S+ 0 0 134 -4,-0.3 -1,-0.3 1,-0.3 -2,-0.1 0.639 125.9 30.8 -84.4 -16.9 3.0 -5.4 14.7 51 51 A Y S < S+ 0 0 115 -3,-1.3 2,-0.8 3,-0.0 -1,-0.3 -0.626 72.0 167.4-135.1 68.6 1.9 -1.7 13.9 52 52 A P + 0 0 83 0, 0.0 2,-0.6 0, 0.0 29,-0.1 -0.087 34.3 120.2 -85.3 42.7 -0.0 -0.7 17.1 53 53 A K > - 0 0 131 -2,-0.8 3,-1.7 1,-0.1 4,-0.3 -0.921 52.5-155.5-108.6 108.4 -0.1 3.1 16.3 54 54 A K G > S+ 0 0 74 -2,-0.6 3,-1.3 1,-0.3 24,-0.5 0.783 89.8 65.2 -56.3 -31.6 -3.7 4.4 16.1 55 55 A E G 3 S+ 0 0 101 1,-0.2 -1,-0.3 22,-0.1 -34,-0.1 0.696 91.6 66.3 -66.6 -18.7 -2.7 7.4 13.8 56 56 A D G < S+ 0 0 26 -3,-1.7 -35,-3.3 -5,-0.1 2,-0.3 0.658 87.9 88.4 -74.1 -21.4 -1.6 4.8 11.0 57 57 A Y E < -K 20 0C 2 -3,-1.3 21,-0.6 -4,-0.3 2,-0.4 -0.636 50.8-168.1 -99.2 145.2 -5.2 3.6 10.4 58 58 A I E -KN 19 77C 9 -39,-2.5 -39,-2.9 -2,-0.3 2,-0.4 -0.989 11.9-162.9-121.0 128.1 -8.1 4.6 8.1 59 59 A V E -KN 18 76C 0 17,-2.1 17,-2.7 -2,-0.4 2,-0.4 -0.967 3.8-167.1-116.9 130.8 -11.6 3.1 8.6 60 60 A Y E -KN 17 75C 24 -43,-2.2 -43,-2.2 -2,-0.4 2,-0.3 -0.944 4.8-168.9-116.0 140.6 -14.4 3.2 6.0 61 61 A L E S+KN 16 74C 0 13,-2.1 13,-2.2 -2,-0.4 56,-0.1 -0.904 75.8 25.3-119.9 147.4 -18.0 2.4 6.4 62 62 A G S S+ 0 0 0 -47,-0.5 2,-0.5 54,-0.5 -1,-0.1 0.728 86.0 139.4 70.8 25.1 -20.4 2.0 3.4 63 63 A R + 0 0 14 -48,-0.4 -1,-0.2 -3,-0.2 6,-0.1 -0.910 26.9 174.8-105.6 126.0 -17.5 1.0 1.1 64 64 A S + 0 0 15 -2,-0.5 90,-2.0 4,-0.1 2,-0.3 0.551 63.6 51.8-104.1 -19.2 -18.1 -1.8 -1.5 65 65 A R B > S-P 153 0D 97 3,-0.5 3,-0.8 88,-0.2 88,-0.2 -0.942 74.5-128.6-127.5 150.1 -14.8 -1.7 -3.5 66 66 A L T 3 S+ 0 0 14 86,-2.5 87,-0.1 -2,-0.3 86,-0.1 0.800 109.2 19.7 -64.6 -32.5 -11.1 -1.8 -2.5 67 67 A N T 3 S+ 0 0 110 85,-0.3 2,-0.3 2,-0.0 -1,-0.2 -0.241 105.1 92.2-137.7 45.9 -10.3 1.3 -4.6 68 68 A S S < S- 0 0 50 -3,-0.8 2,-1.6 84,-0.1 -3,-0.5 -0.996 70.4-130.6-140.5 135.7 -13.6 3.2 -5.2 69 69 A N - 0 0 126 -2,-0.3 3,-0.1 -6,-0.1 4,-0.1 -0.620 37.2-146.6 -86.4 74.3 -15.2 6.0 -3.1 70 70 A T > - 0 0 31 -2,-1.6 3,-2.1 -5,-0.2 2,-0.0 -0.076 25.4 -96.8 -43.7 133.3 -18.6 4.3 -2.9 71 71 A Q T 3 S+ 0 0 191 1,-0.3 -1,-0.1 -8,-0.0 0, 0.0 -0.369 111.8 19.1 -56.1 129.0 -21.6 6.8 -2.9 72 72 A G T 3 S+ 0 0 50 1,-0.3 -1,-0.3 -3,-0.1 44,-0.1 0.452 91.0 143.4 86.1 3.6 -22.7 7.3 0.7 73 73 A E < - 0 0 39 -3,-2.1 2,-0.4 -4,-0.1 -1,-0.3 -0.407 38.2-146.8 -75.1 156.2 -19.4 6.0 2.3 74 74 A M E -N 61 0C 54 -13,-2.2 -13,-2.1 -2,-0.1 2,-0.4 -0.984 4.6-147.8-125.7 132.4 -17.9 7.7 5.4 75 75 A K E -N 60 0C 116 -2,-0.4 31,-0.3 -15,-0.2 2,-0.3 -0.862 20.8-178.1-104.1 136.3 -14.1 8.0 6.2 76 76 A F E -N 59 0C 4 -17,-2.7 -17,-2.1 -2,-0.4 2,-0.2 -0.916 22.2-141.9-134.2 157.2 -12.8 7.9 9.8 77 77 A E E -NO 58 104C 77 27,-3.0 27,-2.0 -2,-0.3 2,-0.7 -0.684 37.8-103.0-107.5 163.1 -9.6 8.1 11.9 78 78 A V E - O 0 103C 4 -21,-0.6 25,-0.2 -24,-0.5 3,-0.2 -0.842 32.2-179.8 -97.0 113.7 -8.9 5.9 14.9 79 79 A E E S+ 0 0 67 23,-2.5 2,-0.3 -2,-0.7 24,-0.2 0.771 78.1 12.4 -75.8 -31.3 -9.5 7.9 18.2 80 80 A N E - O 0 102C 72 22,-1.2 22,-2.8 -26,-0.1 2,-0.6 -0.942 62.4-159.8-153.6 124.4 -8.6 4.8 20.4 81 81 A L E - O 0 101C 26 -2,-0.3 2,-0.6 20,-0.2 20,-0.2 -0.950 15.5-170.0-107.4 113.0 -7.0 1.5 19.4 82 82 A I E - O 0 100C 22 18,-3.2 18,-2.7 -2,-0.6 2,-0.3 -0.922 3.1-174.5-112.8 113.6 -7.7 -1.2 22.0 83 83 A L E - O 0 99C 44 -2,-0.6 2,-0.4 16,-0.2 16,-0.2 -0.753 36.0-101.7-101.9 147.7 -5.9 -4.5 21.8 84 84 A H > - 0 0 23 14,-1.1 3,-1.6 -2,-0.3 14,-0.0 -0.584 27.4-140.1 -72.7 125.4 -6.6 -7.5 24.1 85 85 A K T 3 S+ 0 0 94 -2,-0.4 -1,-0.1 1,-0.3 -2,-0.0 0.752 98.1 48.8 -55.6 -33.4 -3.8 -7.7 26.8 86 86 A D T 3 S+ 0 0 117 10,-0.1 -1,-0.3 2,-0.0 2,-0.1 0.023 79.5 139.7-103.8 30.9 -3.5 -11.5 26.7 87 87 A Y < + 0 0 43 -3,-1.6 2,-0.3 9,-0.1 9,-0.2 -0.451 20.4 159.0 -69.1 143.0 -3.2 -11.9 22.9 88 88 A S E -Q 95 0E 58 7,-1.4 7,-3.1 -2,-0.1 2,-0.4 -0.966 29.7-139.3-160.9 155.5 -0.6 -14.5 21.5 89 89 A A E -Q 94 0E 55 -2,-0.3 5,-0.2 5,-0.2 2,-0.1 -0.987 13.7-171.7-127.3 122.2 -0.0 -16.4 18.3 90 90 A D - 0 0 101 3,-3.4 5,-0.0 -2,-0.4 -2,-0.0 -0.214 56.2 -73.9 -90.4-172.5 1.1 -20.1 18.2 91 91 A T S S- 0 0 145 -2,-0.1 3,-0.0 1,-0.1 -2,-0.0 0.925 125.0 -10.7 -52.8 -44.7 2.1 -21.9 14.9 92 92 A L S S+ 0 0 40 1,-0.1 127,-0.2 126,-0.1 2,-0.1 0.762 119.5 81.0-117.0 -57.2 -1.6 -22.0 13.9 93 93 A A - 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