==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=24-APR-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HORMONE 20-SEP-01 1GMO . COMPND 2 MOLECULE: HEPATOCYTE GROWTH FACTOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR D.LIETHA,D.Y.CHIRGADZE,B.MULLOY,T.L.BLUNDELL,E.GHERARDI . 1369 9 40 40 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 65351.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 747 54.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 16 1.2 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 291 21.3 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 12 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 8 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 2 0.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 129 9.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 177 12.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 70 5.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 16 1.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 7 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 24 1 14 10 19 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 6 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 37 A N 0 0 102 0, 0.0 2,-4.5 0, 0.0 35,-0.2 0.000 360.0 360.0 360.0 174.5 15.1 11.2 8.3 2 38 A T > + 0 0 31 1,-0.2 3,-0.9 2,-0.1 4,-0.1 0.275 360.0 99.8 21.8 -0.2 16.1 14.5 9.9 3 39 A I G > S+ 0 0 22 -2,-4.5 3,-1.4 1,-0.2 -1,-0.2 0.867 76.2 61.5 -74.8 -29.4 18.1 13.0 12.7 4 40 A H G 3 S+ 0 0 149 1,-0.3 -1,-0.2 3,-0.1 -2,-0.1 0.482 88.9 69.0 -72.6 -5.3 21.3 13.8 10.7 5 41 A E G < S+ 0 0 41 -3,-0.9 81,-0.9 2,-0.1 -1,-0.3 0.434 91.6 79.1 -91.5 -1.0 20.6 17.6 10.8 6 42 A F E < S-A 85 0A 16 -3,-1.4 2,-0.7 79,-0.2 79,-0.2 -0.646 84.8-116.5-104.9 163.3 21.3 17.5 14.5 7 43 A K E -A 84 0A 5 77,-2.2 77,-1.6 -2,-0.2 2,-0.1 -0.888 33.5-143.0-102.9 108.7 24.6 17.5 16.4 8 44 A K E -A 83 0A 108 -2,-0.7 75,-0.2 75,-0.2 2,-0.2 -0.373 18.4-174.3 -73.3 145.7 24.9 14.3 18.4 9 45 A S E -A 82 0A 28 73,-2.0 73,-1.8 3,-0.1 3,-0.5 -0.661 24.0-139.9-142.2 83.0 26.5 14.1 21.8 10 46 A A S S+ 0 0 71 1,-0.2 71,-0.2 71,-0.2 3,-0.1 0.142 76.7 9.0 -41.7 151.6 26.7 10.5 23.0 11 47 A K S S+ 0 0 22 67,-0.3 66,-1.0 69,-0.2 2,-0.3 0.830 105.4 116.9 40.4 47.9 26.1 9.5 26.6 12 48 A T E +E 76 0B 28 68,-1.2 2,-0.3 -3,-0.5 64,-0.2 -0.928 32.0 161.8-139.5 164.0 24.8 13.0 27.5 13 49 A T E -E 75 0B 13 62,-1.1 62,-1.1 -2,-0.3 2,-0.2 -0.932 30.7-108.5-164.4 176.9 21.6 14.8 28.6 14 50 A L E -E 74 0B 19 -2,-0.3 2,-0.4 60,-0.2 60,-0.2 -0.676 12.1-147.2-119.6 172.5 20.7 18.1 30.2 15 51 A I E -E 73 0B 41 58,-1.4 2,-1.0 -2,-0.2 58,-0.9 -0.968 16.9-133.6-142.4 123.6 19.5 19.4 33.5 16 52 A K E +E 72 0B 44 -2,-0.4 56,-0.3 56,-0.2 55,-0.1 -0.656 21.0 178.5 -80.0 103.9 17.3 22.4 34.1 17 53 A I S S+ 0 0 65 54,-3.1 55,-0.2 -2,-1.0 -1,-0.2 0.739 76.2 65.7 -73.7 -23.0 18.9 24.5 36.8 18 54 A D S > S- 0 0 69 53,-1.7 3,-0.7 1,-0.1 -1,-0.1 -0.888 74.0-157.2-100.6 120.1 15.9 26.9 36.3 19 55 A P T 3 S+ 0 0 129 0, 0.0 -1,-0.1 0, 0.0 -3,-0.0 0.615 86.4 71.5 -71.7 -9.0 12.6 25.2 37.2 20 56 A A T 3 + 0 0 73 2,-0.1 2,-0.1 -3,-0.0 -3,-0.0 0.799 69.5 97.7 -77.3 -33.2 10.9 27.7 34.9 21 57 A L S < S- 0 0 59 -3,-0.7 -5,-0.1 50,-0.1 2,-0.1 -0.393 75.1-124.6 -62.4 131.9 12.0 26.3 31.5 22 58 A K - 0 0 131 -2,-0.1 2,-0.3 23,-0.1 -1,-0.1 -0.313 29.1-176.8 -76.6 156.8 9.3 24.1 30.0 23 59 A I - 0 0 80 40,-0.1 2,-0.3 41,-0.1 40,-0.2 -0.924 9.5-165.4-145.4 169.8 9.8 20.5 28.8 24 60 A K E -B 62 0A 91 38,-1.1 38,-2.0 -2,-0.3 2,-0.2 -0.898 10.1-179.2-163.6 135.4 7.8 17.7 27.2 25 61 A T E +B 61 0A 63 -2,-0.3 2,-0.3 36,-0.2 36,-0.2 -0.736 9.2 170.2-131.1 174.2 8.3 13.9 26.8 26 62 A K E -B 60 0A 42 34,-0.9 34,-2.9 -2,-0.2 2,-0.6 -0.909 34.7-108.6-177.3 156.6 6.9 10.7 25.3 27 63 A K E +B 59 0A 84 32,-0.3 32,-0.3 -2,-0.3 2,-0.1 -0.873 45.3 160.4-104.3 121.1 7.9 7.1 24.8 28 64 A V - 0 0 34 30,-2.1 3,-0.1 -2,-0.6 -2,-0.0 -0.430 45.9-109.0-122.0-165.2 8.6 6.0 21.2 29 65 A N S S+ 0 0 125 1,-0.2 2,-0.3 -2,-0.1 -1,-0.1 0.818 91.4 17.4 -98.0 -42.5 10.4 3.3 19.2 30 66 A T >> - 0 0 66 1,-0.1 4,-1.0 28,-0.1 3,-0.9 -0.928 68.4-120.4-133.2 158.5 13.5 5.1 17.7 31 67 A A H 3> S+ 0 0 12 -2,-0.3 4,-2.3 1,-0.3 5,-0.1 0.825 109.9 73.0 -63.6 -28.6 15.4 8.3 18.3 32 68 A D H 3> S+ 0 0 68 1,-0.2 4,-3.4 2,-0.2 -1,-0.3 0.876 91.7 55.4 -51.3 -42.6 14.4 9.2 14.7 33 69 A Q H <> S+ 0 0 33 -3,-0.9 4,-2.5 1,-0.2 5,-0.4 0.985 105.8 50.2 -54.9 -57.6 10.9 9.8 15.9 34 70 A a H X S+ 0 0 0 -4,-1.0 4,-1.1 1,-0.2 -2,-0.2 0.887 114.0 46.5 -46.1 -46.8 12.2 12.3 18.5 35 71 A A H >X S+ 0 0 0 -4,-2.3 4,-3.2 1,-0.2 3,-0.9 0.965 110.1 52.4 -59.3 -57.2 14.1 14.0 15.7 36 72 A D H 3X S+ 0 0 70 -4,-3.4 4,-2.0 1,-0.3 6,-0.2 0.869 112.0 43.9 -47.2 -51.0 11.2 14.0 13.3 37 73 A R H 3<>S+ 0 0 28 -4,-2.5 5,-0.8 2,-0.2 -1,-0.3 0.690 114.7 51.0 -73.1 -19.7 8.8 15.6 15.7 38 74 A b H X<5S+ 0 0 2 -4,-1.1 3,-0.6 -3,-0.9 10,-0.3 0.902 108.6 49.6 -82.2 -44.9 11.4 18.2 16.8 39 75 A T H 3<5S+ 0 0 45 -4,-3.2 -2,-0.2 1,-0.3 -3,-0.2 0.940 118.1 40.2 -57.0 -47.9 12.3 19.2 13.3 40 76 A R T 3<5S- 0 0 157 -4,-2.0 -1,-0.3 -5,-0.3 -2,-0.2 0.535 99.2-146.0 -76.2 -8.4 8.6 19.7 12.5 41 77 A N T X 5 + 0 0 4 -3,-0.6 3,-1.0 1,-0.2 2,-0.3 0.762 38.5 165.8 45.7 27.7 8.3 21.2 16.0 42 78 A K T 3 < + 0 0 51 -5,-0.8 -1,-0.2 1,-0.2 -2,-0.1 -0.566 58.5 6.4 -77.5 133.5 4.8 19.6 16.0 43 79 A G T 3 S+ 0 0 53 -2,-0.3 -1,-0.2 240,-0.2 -2,-0.1 0.639 95.7 123.1 74.6 16.6 3.0 19.3 19.4 44 80 A L < - 0 0 7 -3,-1.0 2,-1.9 239,-0.3 -1,-0.2 -0.924 57.7-147.1-118.6 114.3 5.6 21.3 21.3 45 81 A P S S+ 0 0 74 0, 0.0 2,-0.3 0, 0.0 238,-0.2 0.051 85.9 30.5 -64.1 30.9 4.5 24.5 23.2 46 82 A F S S- 0 0 6 -2,-1.9 2,-0.6 236,-0.2 236,-0.2 -0.959 104.4 -70.3-171.2 174.9 7.9 26.0 22.4 47 83 A T - 0 0 6 234,-0.4 2,-1.3 -2,-0.3 3,-0.2 -0.735 47.1-130.1 -83.2 121.3 10.7 25.9 19.8 48 84 A b + 0 0 2 -2,-0.6 3,-0.1 -10,-0.3 -7,-0.1 -0.590 39.1 164.1 -75.2 96.5 12.4 22.5 20.0 49 85 A K - 0 0 24 14,-1.5 36,-3.0 -2,-1.3 2,-0.3 0.700 65.8 -3.8 -85.1 -22.4 16.1 23.6 20.2 50 86 A A E -CD 63 84A 0 13,-1.4 13,-2.9 34,-0.3 2,-0.3 -0.982 59.5-160.4-165.4 158.4 17.3 20.2 21.3 51 87 A F E -CD 62 83A 0 32,-2.8 32,-2.1 -2,-0.3 2,-0.3 -0.997 7.5-148.7-149.0 147.7 16.2 16.7 22.3 52 88 A V E -CD 61 82A 0 9,-1.5 9,-1.3 -2,-0.3 2,-0.5 -0.887 9.3-148.3-115.3 146.3 17.5 13.8 24.2 53 89 A F E -CD 60 81A 21 28,-1.8 28,-1.2 -2,-0.3 2,-1.1 -0.974 2.8-155.0-118.2 122.8 16.7 10.1 23.6 54 90 A D E >>> -CD 59 80A 0 5,-2.8 4,-4.0 -2,-0.5 5,-0.9 -0.698 8.4-172.6 -97.6 80.4 16.7 7.7 26.6 55 91 A K T 345S+ 0 0 58 24,-1.1 -1,-0.2 -2,-1.1 25,-0.1 0.733 81.7 63.1 -41.5 -31.9 17.4 4.4 24.9 56 92 A A T 345S+ 0 0 71 23,-0.6 -1,-0.2 1,-0.2 24,-0.1 0.992 121.1 17.9 -58.9 -64.5 16.8 2.8 28.3 57 93 A R T <45S- 0 0 184 -3,-0.5 -2,-0.2 2,-0.1 -1,-0.2 0.841 102.0-124.8 -75.9 -35.4 13.1 3.8 28.5 58 94 A K T <5 + 0 0 101 -4,-4.0 -30,-2.1 1,-0.3 2,-0.4 0.825 63.3 142.6 84.4 45.3 12.8 4.6 24.8 59 95 A Q E < -BC 27 54A 37 -5,-0.9 -5,-2.8 -32,-0.3 -1,-0.3 -0.914 45.3-137.8-121.9 141.2 11.6 8.1 25.6 60 96 A a E -BC 26 53A 0 -34,-2.9 -34,-0.9 -2,-0.4 2,-0.2 -0.552 7.2-159.8 -92.2 161.4 12.2 11.5 24.0 61 97 A L E -BC 25 52A 28 -9,-1.3 -9,-1.5 -2,-0.2 2,-0.3 -0.714 8.4-167.2-145.2 88.9 13.0 14.7 25.9 62 98 A W E -BC 24 51A 16 -38,-2.0 -38,-1.1 -2,-0.2 -11,-0.2 -0.619 10.1-170.9 -80.0 130.4 12.3 17.9 23.9 63 99 A F E - C 0 50A 6 -13,-2.9 -14,-1.5 -2,-0.3 -13,-1.4 -0.941 33.7-137.7-126.6 148.6 13.7 21.1 25.3 64 100 A P S S+ 0 0 25 0, 0.0 2,-0.3 0, 0.0 -17,-0.1 -0.072 93.7 44.1 -89.3 31.5 13.3 24.8 24.5 65 101 A F - 0 0 4 -15,-0.2 2,-0.2 4,-0.1 -2,-0.2 -0.941 69.0-147.1-159.8 175.4 17.0 25.1 25.1 66 102 A N > - 0 0 6 -2,-0.3 3,-2.1 22,-0.1 -16,-0.1 -0.764 50.1 -67.4-140.1-172.7 20.4 23.3 24.4 67 103 A S T 3 S+ 0 0 14 1,-0.3 7,-0.1 -2,-0.2 5,-0.1 0.769 130.9 49.9 -56.1 -26.3 23.7 22.8 26.1 68 104 A M T 3 S+ 0 0 76 5,-0.1 2,-0.5 2,-0.1 -1,-0.3 0.564 83.4 114.1 -89.7 -4.5 24.7 26.5 25.8 69 105 A S S X S- 0 0 26 -3,-2.1 3,-1.0 1,-0.1 -4,-0.1 -0.516 71.2-124.5 -68.5 116.2 21.3 27.6 27.3 70 106 A S T 3 S+ 0 0 112 -2,-0.5 3,-0.1 1,-0.2 -52,-0.1 -0.229 97.1 39.8 -58.5 149.0 22.0 29.2 30.7 71 107 A G T 3 S+ 0 0 27 1,-0.4 -54,-3.1 -54,-0.1 -53,-1.7 0.523 107.2 89.9 85.6 4.7 20.0 27.7 33.6 72 108 A V E < -E 16 0B 11 -3,-1.0 -1,-0.4 -56,-0.3 2,-0.3 -0.856 57.0-168.7-127.9 164.0 20.8 24.4 32.0 73 109 A K E -E 15 0B 135 -58,-0.9 -58,-1.4 -2,-0.3 2,-0.1 -0.995 19.2-119.2-156.4 151.9 23.7 22.0 32.4 74 110 A K E +E 14 0B 108 -2,-0.3 2,-0.3 -60,-0.2 -60,-0.2 -0.435 31.0 172.6 -87.0 163.7 25.3 18.9 30.8 75 111 A E E -E 13 0B 130 -62,-1.1 -62,-1.1 -2,-0.1 2,-0.1 -0.927 29.2-108.1-170.0 146.1 25.7 15.5 32.5 76 112 A F E +E 12 0B 157 -2,-0.3 2,-0.2 -64,-0.2 -64,-0.2 -0.397 39.0 152.4 -79.7 156.4 26.8 12.0 31.7 77 113 A G > - 0 0 10 -66,-1.0 3,-1.0 3,-0.2 -2,-0.1 -0.711 39.4-139.6 179.2 126.4 24.6 9.0 31.5 78 114 A H T 3 S+ 0 0 83 1,-0.2 -67,-0.3 -2,-0.2 -66,-0.1 0.754 103.5 54.4 -69.4 -24.9 25.1 5.9 29.4 79 115 A E T 3 S+ 0 0 76 -68,-0.1 -24,-1.1 -25,-0.1 -23,-0.6 0.499 97.5 88.7 -86.1 -3.6 21.4 5.6 28.4 80 116 A F E < - D 0 54A 38 -3,-1.0 -68,-1.2 -26,-0.2 2,-0.4 -0.799 48.4-176.7-108.0 139.2 21.4 9.2 27.1 81 117 A D E - D 0 53A 40 -28,-1.2 -28,-1.8 -2,-0.4 2,-0.4 -0.991 18.0-144.6-130.3 122.6 22.1 10.8 23.7 82 118 A L E -AD 9 52A 2 -73,-1.8 -73,-2.0 -2,-0.4 2,-0.5 -0.749 14.4-175.1 -93.5 133.2 22.0 14.5 23.1 83 119 A Y E -AD 8 51A 10 -32,-2.1 -32,-2.8 -2,-0.4 2,-0.4 -0.971 5.7-167.8-127.1 112.2 20.8 16.0 19.9 84 120 A E E -AD 7 50A 2 -77,-1.6 -77,-2.2 -2,-0.5 2,-0.5 -0.848 25.5-118.5-105.6 140.7 21.0 19.7 19.4 85 121 A N E > -A 6 0A 24 -36,-3.0 3,-2.1 -2,-0.4 -79,-0.2 -0.641 19.5-140.5 -75.2 121.9 19.3 21.6 16.5 86 122 A K G > S+ 0 0 55 -81,-0.9 3,-1.6 -2,-0.5 -1,-0.1 0.732 95.4 70.3 -57.1 -26.7 21.9 23.3 14.4 87 123 A D G 3 S+ 0 0 26 1,-0.3 -1,-0.3 189,-0.0 4,-0.1 0.718 102.4 46.4 -65.1 -17.9 19.9 26.4 13.9 88 124 A Y G < S+ 0 0 24 -3,-2.1 2,-0.7 -39,-0.2 -1,-0.3 0.272 90.8 87.5-110.1 12.9 20.5 27.2 17.6 89 125 A I S < S- 0 0 8 -3,-1.6 14,-0.2 -4,-0.1 175,-0.1 -0.944 93.1-109.0-112.8 108.0 24.2 26.5 17.7 90 126 A R - 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