==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=17-MAY-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE/HYDROLASE INHIBITOR 24-AUG-12 4GR8 . COMPND 2 MOLECULE: MACROPHAGE METALLOELASTASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR E.A.STURA,L.VERA,F.BEAU,L.DEVEL,E.CASSAR-LAJEUNESSE,V.DIVE . 152 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 7993.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 80 52.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 17 11.2 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 4 2.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 7 4.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 14 9.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 32 21.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 111 A K 0 0 200 0, 0.0 36,-0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 155.8 -3.6 4.7 12.5 2 112 A H + 0 0 87 35,-0.1 36,-3.1 34,-0.1 2,-0.6 0.548 360.0 86.9-103.2 -9.5 -1.9 4.0 9.2 3 113 A Y E +a 38 0A 107 34,-0.2 2,-0.4 36,-0.0 36,-0.2 -0.832 56.9 173.6 -94.4 116.9 -4.8 2.2 7.6 4 114 A I E -a 39 0A 21 34,-2.8 36,-1.7 -2,-0.6 2,-0.3 -0.986 16.1-152.3-132.2 130.3 -7.1 4.7 5.9 5 115 A T E -a 40 0A 15 -2,-0.4 44,-2.5 34,-0.2 2,-0.3 -0.689 10.4-171.5-102.0 153.8 -10.1 4.1 3.6 6 116 A Y E -ab 41 49A 8 34,-2.3 36,-2.8 -2,-0.3 2,-0.3 -0.957 7.4-165.1-138.2 155.3 -11.6 6.2 0.8 7 117 A R E - b 0 50A 48 42,-2.2 44,-2.6 -2,-0.3 2,-1.0 -0.983 22.5-134.0-138.7 135.5 -14.7 6.2 -1.3 8 118 A I E - b 0 51A 12 34,-0.4 44,-0.2 -2,-0.3 3,-0.1 -0.815 23.0-169.2 -87.3 103.4 -15.3 8.1 -4.5 9 119 A N - 0 0 78 42,-2.2 2,-0.3 -2,-1.0 43,-0.2 0.854 62.8 -8.9 -64.1 -39.1 -18.8 9.3 -3.7 10 120 A N - 0 0 50 41,-0.9 2,-0.5 -3,-0.1 -1,-0.2 -0.977 66.0-118.5-158.6 167.8 -19.5 10.6 -7.2 11 121 A Y - 0 0 42 -2,-0.3 6,-0.1 -3,-0.1 41,-0.0 -0.941 23.3-121.4-123.6 127.7 -17.9 11.2 -10.6 12 122 A T > - 0 0 2 -2,-0.5 3,-1.2 1,-0.2 8,-0.1 -0.418 16.6-139.6 -60.5 134.0 -17.5 14.5 -12.5 13 123 A P T 3 S+ 0 0 111 0, 0.0 -1,-0.2 0, 0.0 4,-0.1 0.642 95.0 79.6 -70.9 -9.7 -19.2 14.2 -15.9 14 124 A D T 3 S+ 0 0 45 77,-0.1 2,-0.3 75,-0.1 -2,-0.0 0.761 98.3 40.3 -62.1 -27.5 -16.2 16.2 -17.3 15 125 A M S < S- 0 0 21 -3,-1.2 2,-0.2 79,-0.1 79,-0.1 -0.782 93.9 -92.4-123.9 162.3 -14.1 13.0 -17.3 16 126 A N >> - 0 0 95 -2,-0.3 4,-1.7 1,-0.1 3,-0.7 -0.561 38.9-125.2 -68.2 140.0 -14.4 9.3 -18.1 17 127 A R H 3> S+ 0 0 149 1,-0.3 4,-2.3 -2,-0.2 3,-0.2 0.892 111.6 54.0 -54.4 -44.3 -15.4 7.4 -14.9 18 128 A E H 3> S+ 0 0 127 1,-0.2 4,-2.1 2,-0.2 -1,-0.3 0.817 106.0 53.1 -59.8 -33.3 -12.3 5.1 -15.3 19 129 A D H <> S+ 0 0 52 -3,-0.7 4,-2.7 2,-0.2 -1,-0.2 0.828 106.9 51.2 -74.7 -34.9 -10.1 8.2 -15.5 20 130 A V H X S+ 0 0 0 -4,-1.7 4,-2.6 -3,-0.2 5,-0.3 0.951 110.4 49.4 -64.2 -48.1 -11.4 9.6 -12.3 21 131 A D H X S+ 0 0 44 -4,-2.3 4,-2.5 1,-0.2 -2,-0.2 0.917 114.8 45.7 -55.4 -44.8 -10.8 6.2 -10.6 22 132 A Y H X S+ 0 0 136 -4,-2.1 4,-2.8 2,-0.2 5,-0.2 0.933 111.6 49.4 -67.5 -45.5 -7.2 6.2 -11.9 23 133 A A H X S+ 0 0 10 -4,-2.7 4,-2.1 1,-0.2 -1,-0.2 0.916 114.9 45.4 -60.6 -44.4 -6.4 9.8 -11.1 24 134 A I H X S+ 0 0 0 -4,-2.6 4,-2.3 2,-0.2 5,-0.2 0.925 112.0 51.1 -66.2 -45.4 -7.6 9.3 -7.5 25 135 A R H X S+ 0 0 135 -4,-2.5 4,-2.2 -5,-0.3 -2,-0.2 0.935 112.0 47.5 -57.1 -45.9 -5.8 6.0 -7.1 26 136 A K H X S+ 0 0 67 -4,-2.8 4,-1.9 2,-0.2 -1,-0.2 0.870 108.2 55.5 -65.6 -36.2 -2.6 7.6 -8.3 27 137 A A H X S+ 0 0 0 -4,-2.1 4,-1.1 -5,-0.2 -1,-0.2 0.920 110.3 44.7 -63.0 -43.3 -3.0 10.6 -6.0 28 138 A F H X S+ 0 0 4 -4,-2.3 4,-2.6 1,-0.2 3,-0.3 0.915 109.5 57.3 -63.5 -41.2 -3.3 8.3 -3.0 29 139 A Q H X S+ 0 0 78 -4,-2.2 4,-2.1 1,-0.2 -2,-0.2 0.856 98.4 61.5 -56.1 -37.8 -0.3 6.3 -4.2 30 140 A V H < S+ 0 0 24 -4,-1.9 4,-0.3 1,-0.2 -1,-0.2 0.926 112.4 35.9 -57.7 -45.2 1.8 9.5 -4.3 31 141 A W H >< S+ 0 0 0 -4,-1.1 3,-1.1 -3,-0.3 6,-0.3 0.841 113.2 57.7 -78.5 -34.3 1.4 9.8 -0.5 32 142 A S H >< S+ 0 0 35 -4,-2.6 3,-1.1 1,-0.2 -2,-0.2 0.835 98.8 63.1 -62.1 -30.9 1.4 6.1 0.2 33 143 A N T 3< S+ 0 0 115 -4,-2.1 -1,-0.2 1,-0.2 -2,-0.2 0.637 108.3 38.8 -73.4 -12.8 4.8 5.9 -1.4 34 144 A V T < S+ 0 0 35 -3,-1.1 -1,-0.2 -4,-0.3 -2,-0.2 0.198 118.0 42.2-123.1 15.1 6.5 8.2 1.2 35 145 A T S < S- 0 0 21 -3,-1.1 114,-0.1 2,-0.2 -33,-0.0 -0.902 86.1-105.7-145.6 172.2 4.8 7.0 4.3 36 146 A P S S+ 0 0 73 0, 0.0 -4,-0.1 0, 0.0 2,-0.1 0.336 76.0 132.0 -83.5 11.9 3.7 3.8 6.1 37 147 A L - 0 0 4 -6,-0.3 2,-0.5 -5,-0.1 -34,-0.2 -0.347 42.9-159.7 -68.2 138.5 0.1 4.7 5.1 38 148 A K E -a 3 0A 128 -36,-3.1 -34,-2.8 -2,-0.1 2,-0.3 -0.986 7.5-159.8-118.6 120.0 -2.1 2.0 3.5 39 149 A F E -a 4 0A 25 -2,-0.5 2,-0.4 -36,-0.2 -34,-0.2 -0.794 5.3-168.5-101.4 144.9 -5.1 3.2 1.6 40 150 A S E -a 5 0A 34 -36,-1.7 -34,-2.3 -2,-0.3 2,-0.3 -0.993 16.6-134.8-135.9 125.7 -8.1 1.0 0.7 41 151 A K E -a 6 0A 57 -2,-0.4 2,-0.4 -36,-0.2 -34,-0.2 -0.634 17.7-163.7 -82.9 133.5 -10.8 1.9 -1.7 42 152 A I - 0 0 40 -36,-2.8 -34,-0.4 -2,-0.3 3,-0.1 -0.950 12.3-169.0-116.9 135.5 -14.5 1.2 -0.7 43 153 A N S S+ 0 0 122 -2,-0.4 2,-0.4 1,-0.3 -1,-0.1 0.788 76.3 18.2 -92.3 -31.5 -17.3 1.2 -3.2 44 154 A T S S+ 0 0 129 2,-0.1 -1,-0.3 -37,-0.0 2,-0.2 -0.996 106.1 11.8-144.6 132.3 -20.2 1.2 -0.7 45 155 A G S S+ 0 0 40 -2,-0.4 2,-0.2 -3,-0.1 -3,-0.1 -0.592 95.9 3.2 106.2-164.0 -20.5 2.2 2.9 46 156 A M + 0 0 181 -2,-0.2 2,-0.3 2,-0.0 -2,-0.1 -0.374 59.2 165.3 -71.4 130.6 -18.4 3.9 5.5 47 157 A A - 0 0 20 -2,-0.2 -41,-0.1 1,-0.1 3,-0.1 -0.990 38.6-132.9-140.8 149.4 -15.0 5.3 4.4 48 158 A D S S+ 0 0 82 -2,-0.3 2,-0.6 1,-0.2 -42,-0.2 0.937 96.2 38.8 -64.6 -50.5 -12.6 7.8 6.1 49 159 A I E S-b 6 0A 4 -44,-2.5 -42,-2.2 35,-0.1 2,-0.5 -0.910 70.8-164.8-109.3 110.9 -12.0 10.0 3.1 50 160 A L E -b 7 0A 31 -2,-0.6 35,-2.7 -44,-0.2 2,-0.6 -0.839 9.8-149.8 -92.8 133.0 -14.9 10.8 0.7 51 161 A V E +bc 8 85A 1 -44,-2.6 -42,-2.2 -2,-0.5 -41,-0.9 -0.910 27.5 178.2 -99.2 117.6 -14.1 12.2 -2.7 52 162 A V E - c 0 86A 22 33,-2.5 35,-2.9 -2,-0.6 2,-0.5 -0.976 26.1-156.0-129.5 137.6 -16.9 14.4 -3.8 53 163 A F E + c 0 87A 7 -2,-0.4 2,-0.3 33,-0.2 35,-0.2 -0.958 35.6 143.8-108.8 129.4 -17.7 16.6 -6.7 54 164 A A E - c 0 88A 20 33,-2.3 35,-2.2 -2,-0.5 36,-0.4 -0.986 35.5-133.9-159.4 158.9 -20.2 19.4 -6.1 55 165 A R - 0 0 138 -2,-0.3 33,-0.0 33,-0.2 10,-0.0 -0.861 62.0 -18.8-119.9 158.4 -21.0 23.0 -6.9 56 166 A G S S+ 0 0 25 -2,-0.3 8,-2.4 7,-0.1 2,-0.3 -0.110 122.1 4.9 52.2-143.7 -22.0 26.1 -4.9 57 167 A A + 0 0 90 6,-0.3 -2,-0.2 1,-0.1 6,-0.1 -0.556 67.9 169.2 -72.4 130.0 -23.3 25.4 -1.4 58 168 A H - 0 0 44 -2,-0.3 -1,-0.1 -4,-0.1 -2,-0.1 0.009 59.7 -78.8-141.8 29.1 -23.0 21.6 -0.8 59 169 A G S S+ 0 0 80 1,-0.0 -2,-0.1 0, 0.0 4,-0.0 0.266 106.7 84.3 105.1 -9.4 -23.7 21.1 2.9 60 170 A D S S- 0 0 8 2,-0.1 -3,-0.0 21,-0.0 -1,-0.0 0.148 95.7-107.3-119.5 20.4 -20.6 22.0 4.8 61 171 A D S S+ 0 0 159 1,-0.1 2,-0.2 0, 0.0 -4,-0.1 0.596 99.9 93.4 65.3 11.0 -20.6 25.8 5.4 62 172 A H - 0 0 106 -6,-0.1 -1,-0.1 11,-0.0 -2,-0.1 -0.600 63.4-168.3-128.9 72.6 -17.9 26.2 2.8 63 173 A A - 0 0 64 -2,-0.2 -6,-0.3 1,-0.1 2,-0.1 -0.269 20.6-117.6 -63.6 144.5 -19.7 26.9 -0.4 64 174 A F - 0 0 13 -8,-2.4 3,-0.1 1,-0.1 -1,-0.1 -0.382 15.9-136.3 -78.2 167.5 -17.8 26.8 -3.7 65 175 A D - 0 0 85 5,-0.4 -1,-0.1 1,-0.4 2,-0.1 0.084 39.4-102.1-122.9 19.7 -17.6 29.9 -5.9 66 176 A G S S- 0 0 20 4,-0.1 -1,-0.4 3,-0.0 24,-0.1 -0.297 76.8 -9.2 83.6-173.0 -18.2 29.0 -9.5 67 177 A K S S+ 0 0 164 23,-0.1 24,-0.1 -3,-0.1 2,-0.1 -0.321 120.2 3.0 -65.0 134.1 -15.6 28.6 -12.2 68 178 A G S S+ 0 0 29 1,-0.2 -3,-0.2 2,-0.1 22,-0.1 -0.440 98.1 70.4 88.3-166.8 -12.2 29.7 -11.2 69 179 A G S S+ 0 0 68 -2,-0.1 2,-0.4 -5,-0.1 -1,-0.2 -0.337 105.2 21.9 57.9-128.4 -11.2 31.0 -7.7 70 180 A I - 0 0 94 1,-0.2 -5,-0.4 -3,-0.1 3,-0.1 -0.554 65.8-175.5 -73.6 124.9 -11.3 28.1 -5.3 71 181 A L - 0 0 35 -2,-0.4 17,-2.4 1,-0.3 2,-0.3 0.723 61.6 -23.0 -90.6 -26.3 -10.9 24.8 -7.1 72 182 A A E -D 87 0A 8 15,-0.3 -1,-0.3 -19,-0.0 2,-0.3 -0.954 55.1-157.9-173.6 164.6 -11.4 22.4 -4.3 73 183 A H E -D 86 0A 35 13,-2.2 13,-3.1 -2,-0.3 2,-0.3 -0.973 4.8-163.5-155.8 164.2 -11.0 22.0 -0.5 74 184 A A E -D 85 0A 20 -2,-0.3 2,-0.3 11,-0.2 11,-0.2 -0.994 14.9-128.8-152.6 155.4 -10.6 19.3 2.1 75 185 A F - 0 0 41 9,-2.0 8,-0.6 6,-0.4 3,-0.1 -0.817 29.6-109.9-108.7 143.0 -10.9 18.8 5.8 76 186 A G - 0 0 37 -2,-0.3 7,-1.4 1,-0.2 8,-0.2 -0.142 61.5 -58.4 -62.5 165.4 -8.3 17.3 8.2 77 187 A P S S+ 0 0 84 0, 0.0 2,-0.3 0, 0.0 -1,-0.2 -0.121 85.6 103.6 -53.4 136.2 -8.9 13.8 9.7 78 188 A G - 0 0 52 4,-0.2 2,-0.1 -30,-0.2 -3,-0.0 -0.971 69.1 -53.0 175.5-173.5 -12.1 13.4 11.7 79 189 A S S > S- 0 0 116 -2,-0.3 3,-2.5 2,-0.1 2,-0.1 -0.390 101.3 -7.0 -78.3 162.0 -15.6 12.0 11.7 80 190 A G T 3 S+ 0 0 65 1,-0.3 -2,-0.1 -2,-0.1 4,-0.1 -0.293 143.5 9.0 59.3-122.0 -18.1 12.8 9.0 81 191 A I T > S+ 0 0 80 2,-0.1 3,-2.3 -2,-0.1 -6,-0.4 0.650 102.5 118.0 -69.1 -10.8 -16.8 15.4 6.7 82 192 A G T < S+ 0 0 8 -3,-2.5 -4,-0.2 1,-0.3 -32,-0.2 -0.325 84.6 10.9 -51.7 132.8 -13.4 15.1 8.4 83 193 A G T 3 S+ 0 0 4 -7,-1.4 -1,-0.3 -8,-0.6 30,-0.1 0.257 96.7 138.0 80.2 -13.3 -10.9 13.9 5.8 84 194 A D < - 0 0 7 -3,-2.3 -9,-2.0 -8,-0.2 2,-0.5 -0.384 42.7-149.8 -76.7 146.8 -13.3 14.5 2.9 85 195 A A E -cD 51 74A 0 -35,-2.7 -33,-2.5 -11,-0.2 2,-0.4 -0.975 11.9-164.9-118.4 120.4 -12.0 16.1 -0.3 86 196 A H E -cD 52 73A 9 -13,-3.1 -13,-2.2 -2,-0.5 2,-0.4 -0.917 3.3-160.8-113.9 132.9 -14.4 18.2 -2.3 87 197 A F E -cD 53 72A 2 -35,-2.9 -33,-2.3 -2,-0.4 2,-0.5 -0.951 26.0-117.8-118.4 129.7 -13.9 19.3 -5.9 88 198 A D E > -c 54 0A 0 -17,-2.4 3,-2.0 -2,-0.4 -33,-0.2 -0.549 16.7-156.1 -70.3 114.1 -15.8 22.2 -7.4 89 199 A E T 3 S+ 0 0 18 -35,-2.2 -34,-0.2 -2,-0.5 -1,-0.2 0.707 88.3 74.7 -67.1 -18.0 -17.9 20.9 -10.3 90 200 A D T 3 S+ 0 0 49 -36,-0.4 -1,-0.3 -24,-0.1 2,-0.1 0.674 85.7 80.4 -70.0 -13.1 -17.9 24.4 -11.8 91 201 A E S < S- 0 0 7 -3,-2.0 2,-0.7 -20,-0.2 -77,-0.1 -0.477 90.4-118.2 -79.3 163.3 -14.3 23.7 -12.8 92 202 A F - 0 0 93 -2,-0.1 8,-3.0 -78,-0.0 2,-0.3 -0.910 31.6-152.3-105.4 104.9 -13.5 21.6 -15.8 93 203 A W E +e 100 0B 1 -2,-0.7 2,-0.3 6,-0.2 8,-0.2 -0.584 21.7 172.3 -84.7 135.3 -11.6 18.5 -14.6 94 204 A T E -e 101 0B 4 6,-2.2 8,-2.3 -2,-0.3 9,-0.4 -0.921 47.2-134.8-141.3 163.8 -9.2 16.8 -16.9 95 205 A T S S+ 0 0 77 -2,-0.3 2,-0.1 6,-0.2 6,-0.1 0.459 94.9 46.2 -88.0 -6.4 -6.5 14.2 -17.3 96 206 A H S S- 0 0 96 2,-0.2 -2,-0.2 4,-0.1 6,-0.1 -0.225 106.0 -75.0-120.8-163.8 -4.4 16.7 -19.2 97 207 A S S S+ 0 0 81 -2,-0.1 4,-0.2 3,-0.1 35,-0.1 0.705 97.4 92.6 -69.4 -30.2 -3.2 20.4 -19.2 98 208 A G S S- 0 0 26 2,-0.1 -2,-0.2 -5,-0.0 -4,-0.1 -0.301 95.8 -11.7 -68.2 156.9 -6.5 21.8 -20.2 99 209 A G S S- 0 0 47 -6,-0.1 2,-0.5 1,-0.1 -6,-0.2 -0.212 121.8 -29.0 52.2-136.2 -8.9 23.0 -17.5 100 210 A T E -e 93 0B 14 -8,-3.0 -6,-2.2 -29,-0.0 2,-0.4 -0.960 64.6-124.9-117.3 121.3 -7.8 21.8 -14.1 101 211 A N E > -e 94 0B 1 -2,-0.5 4,-1.9 -8,-0.2 5,-0.2 -0.491 15.4-156.1 -67.3 120.4 -5.9 18.6 -13.8 102 212 A L H > S+ 0 0 0 -8,-2.3 4,-3.0 -2,-0.4 5,-0.2 0.924 88.2 55.8 -66.4 -44.8 -7.7 16.3 -11.3 103 213 A F H > S+ 0 0 22 -9,-0.4 4,-2.2 1,-0.2 -1,-0.2 0.936 111.0 43.1 -52.0 -52.2 -4.6 14.2 -10.4 104 214 A L H > S+ 0 0 9 1,-0.2 4,-1.9 2,-0.2 -1,-0.2 0.917 115.4 48.4 -64.4 -43.6 -2.6 17.3 -9.2 105 215 A T H X S+ 0 0 7 -4,-1.9 4,-2.7 1,-0.2 -1,-0.2 0.909 110.9 52.1 -62.5 -42.4 -5.5 18.9 -7.4 106 216 A A H X S+ 0 0 0 -4,-3.0 4,-3.0 2,-0.2 5,-0.3 0.878 105.1 54.5 -63.4 -37.8 -6.3 15.6 -5.7 107 217 A V H X S+ 0 0 0 -4,-2.2 4,-1.8 -5,-0.2 -1,-0.2 0.953 111.9 45.3 -59.3 -46.6 -2.7 15.2 -4.5 108 218 A H H X S+ 0 0 28 -4,-1.9 4,-1.7 2,-0.2 -2,-0.2 0.940 115.7 45.9 -59.6 -48.8 -3.0 18.7 -2.9 109 219 A E H X S+ 0 0 12 -4,-2.7 4,-2.7 1,-0.2 -2,-0.2 0.901 109.1 52.7 -68.3 -40.9 -6.3 18.0 -1.4 110 220 A I H X S+ 0 0 1 -4,-3.0 4,-1.8 2,-0.2 -1,-0.2 0.877 103.9 60.4 -60.4 -35.5 -5.5 14.5 -0.0 111 221 A G H <>S+ 0 0 0 -4,-1.8 5,-2.6 -5,-0.3 4,-0.5 0.954 108.7 42.2 -52.0 -51.4 -2.5 16.3 1.6 112 222 A H H ><5S+ 0 0 35 -4,-1.7 3,-1.2 1,-0.2 -2,-0.2 0.893 109.2 58.7 -61.6 -42.6 -5.1 18.4 3.5 113 223 A S H 3<5S+ 0 0 2 -4,-2.7 -1,-0.2 1,-0.3 -2,-0.2 0.797 106.8 48.7 -54.8 -32.5 -7.2 15.3 4.1 114 224 A L T 3<5S- 0 0 3 -4,-1.8 -1,-0.3 -3,-0.5 -2,-0.2 0.513 131.5 -91.5 -89.2 -8.0 -4.3 13.8 6.0 115 225 A G T < 5S+ 0 0 39 -3,-1.2 -3,-0.2 -4,-0.5 2,-0.1 0.445 75.5 143.1 114.9 3.5 -3.6 16.9 8.0 116 226 A L < - 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