==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=3-MAY-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 27-AUG-12 4GRY . COMPND 2 MOLECULE: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR N.L.ALICEA-VELAZQUEZ,J.JAKONCIC,T.J.BOGGON . 271 3 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 13902.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 185 68.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 15 5.5 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 33 12.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 0.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 21 7.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 31 11.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 79 29.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 0.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 0 1 2 0 0 0 0 1 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 1 0 2 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 243 A G > 0 0 66 0, 0.0 4,-2.3 0, 0.0 5,-0.2 0.000 360.0 360.0 360.0-141.9 -8.1 -16.3 -7.1 2 244 A F H > + 0 0 135 1,-0.2 4,-2.8 2,-0.2 5,-0.2 0.904 360.0 45.3 -55.7 -51.9 -9.9 -13.0 -7.1 3 245 A W H > S+ 0 0 179 1,-0.2 4,-2.4 2,-0.2 -1,-0.2 0.826 112.3 51.9 -67.7 -31.8 -12.8 -13.9 -4.9 4 246 A E H > S+ 0 0 132 -3,-0.2 4,-1.9 2,-0.2 -1,-0.2 0.931 113.5 44.1 -66.7 -44.9 -10.6 -15.6 -2.3 5 247 A E H X S+ 0 0 121 -4,-2.3 4,-2.1 2,-0.2 -2,-0.2 0.905 114.5 50.0 -65.5 -42.5 -8.4 -12.5 -2.1 6 248 A F H X S+ 0 0 79 -4,-2.8 4,-2.3 -5,-0.2 -2,-0.2 0.918 108.7 52.0 -60.6 -46.6 -11.4 -10.2 -2.0 7 249 A E H X S+ 0 0 105 -4,-2.4 4,-1.6 1,-0.2 -1,-0.2 0.891 109.2 51.5 -57.2 -41.5 -13.0 -12.3 0.8 8 250 A S H X S+ 0 0 53 -4,-1.9 4,-0.7 1,-0.2 -1,-0.2 0.910 108.9 49.0 -63.6 -44.5 -9.8 -12.0 2.7 9 251 A L H >< S+ 0 0 107 -4,-2.1 3,-0.9 1,-0.2 4,-0.4 0.874 107.6 55.2 -64.8 -37.8 -9.6 -8.2 2.4 10 252 A Q H >< S+ 0 0 97 -4,-2.3 3,-1.3 1,-0.3 -1,-0.2 0.881 101.5 58.6 -62.9 -36.6 -13.2 -7.9 3.5 11 253 A K H 3< S+ 0 0 139 -4,-1.6 -1,-0.3 1,-0.2 -2,-0.2 0.746 103.9 54.2 -59.9 -24.6 -12.3 -9.9 6.6 12 254 A Q T << S+ 0 0 88 -3,-0.9 -1,-0.2 -4,-0.7 -2,-0.2 0.485 77.8 119.7 -93.9 -4.8 -9.8 -7.1 7.4 13 255 A E < + 0 0 68 -3,-1.3 -3,-0.0 -4,-0.4 228,-0.0 -0.361 26.1 164.0 -59.5 138.0 -12.2 -4.2 7.2 14 256 A V >> + 0 0 26 2,-0.1 4,-2.9 3,-0.1 3,-1.6 0.578 61.9 74.2-125.6 -29.3 -12.3 -2.2 10.5 15 257 A K T 34 S+ 0 0 101 1,-0.3 5,-0.1 2,-0.2 -2,-0.1 0.712 97.5 53.9 -62.5 -21.8 -14.0 1.1 9.5 16 258 A N T 34 S+ 0 0 109 1,-0.1 -1,-0.3 3,-0.1 3,-0.1 0.664 116.8 37.2 -81.7 -18.7 -17.3 -0.8 9.3 17 259 A L T <4 S+ 0 0 145 -3,-1.6 2,-0.5 1,-0.2 -2,-0.2 0.690 114.6 53.8-106.7 -24.7 -16.8 -2.2 12.8 18 260 A H S < S- 0 0 60 -4,-2.9 -1,-0.2 23,-0.0 -4,-0.1 -0.962 78.1-138.6-116.3 123.4 -15.3 0.8 14.6 19 261 A Q - 0 0 125 -2,-0.5 22,-2.4 -3,-0.1 23,-0.4 -0.289 11.4-161.9 -73.9 161.2 -17.0 4.2 14.5 20 262 A R > + 0 0 59 20,-0.2 4,-1.1 21,-0.1 20,-0.1 -0.340 41.1 138.8-132.9 47.4 -15.2 7.6 14.0 21 263 A L H >> + 0 0 80 1,-0.2 4,-0.6 2,-0.2 3,-0.6 0.920 65.0 53.7 -61.5 -47.4 -18.0 9.8 15.3 22 264 A E H >4 S+ 0 0 31 1,-0.3 3,-1.2 2,-0.2 -1,-0.2 0.922 108.5 48.1 -61.2 -44.7 -16.0 12.2 17.3 23 265 A G H 34 S+ 0 0 1 16,-0.4 -1,-0.3 1,-0.3 -2,-0.2 0.746 110.0 53.3 -68.4 -24.3 -13.6 13.2 14.5 24 266 A Q H << S+ 0 0 109 -4,-1.1 -1,-0.3 -3,-0.6 -2,-0.2 0.483 77.9 120.4 -88.1 -5.6 -16.5 13.7 12.0 25 267 A R X< - 0 0 96 -3,-1.2 3,-2.2 -4,-0.6 4,-0.2 -0.403 69.2-130.7 -61.3 135.8 -18.4 16.1 14.3 26 268 A P G > S+ 0 0 105 0, 0.0 3,-1.9 0, 0.0 4,-0.3 0.880 108.2 62.3 -52.4 -39.5 -18.8 19.5 12.5 27 269 A E G 3 S+ 0 0 86 1,-0.3 3,-0.2 2,-0.1 -2,-0.1 0.701 104.9 47.8 -62.8 -16.5 -17.6 21.2 15.7 28 270 A N G X S+ 0 0 0 -3,-2.2 3,-2.1 -6,-0.2 4,-0.3 0.327 77.1 108.3-105.2 9.2 -14.2 19.3 15.2 29 271 A K G X S+ 0 0 145 -3,-1.9 3,-1.1 1,-0.3 -1,-0.1 0.849 77.7 51.8 -54.9 -40.4 -13.7 20.2 11.5 30 272 A G G 3 S+ 0 0 55 -4,-0.3 -1,-0.3 1,-0.2 55,-0.2 0.422 100.3 65.4 -79.0 2.8 -10.9 22.6 12.2 31 273 A K G < S+ 0 0 39 -3,-2.1 2,-0.4 -8,-0.1 30,-0.4 0.447 88.8 76.1-105.9 -4.0 -9.0 20.1 14.3 32 274 A N < - 0 0 18 -3,-1.1 3,-0.2 -4,-0.3 6,-0.1 -0.921 59.9-159.8-108.8 130.9 -8.4 17.6 11.4 33 275 A R S S+ 0 0 70 -2,-0.4 2,-0.5 1,-0.3 -1,-0.1 0.901 94.0 28.4 -72.4 -36.6 -5.7 18.3 8.8 34 276 A Y S > S- 0 0 98 3,-0.4 3,-2.5 1,-0.1 -1,-0.3 -0.968 74.7-148.4-127.3 116.0 -7.5 15.8 6.5 35 277 A K T 3 S+ 0 0 146 -2,-0.5 -1,-0.1 1,-0.3 -2,-0.0 0.726 99.5 50.1 -56.9 -20.5 -11.3 15.4 6.9 36 278 A N T 3 S+ 0 0 132 1,-0.1 2,-0.6 -3,-0.0 -1,-0.3 0.380 94.7 76.3-103.3 3.3 -11.0 11.8 5.8 37 279 A I < + 0 0 43 -3,-2.5 -3,-0.4 -14,-0.1 -4,-0.2 -0.914 66.8 152.6-116.6 104.2 -8.2 10.7 8.2 38 280 A L - 0 0 7 -2,-0.6 206,-0.4 -6,-0.1 2,-0.2 -0.886 44.1-103.2-137.6 155.6 -9.7 10.4 11.6 39 281 A P - 0 0 0 0, 0.0 -16,-0.4 0, 0.0 2,-0.2 -0.552 37.8-111.4 -78.9 142.0 -9.2 8.5 14.9 40 282 A F >> - 0 0 0 202,-0.4 3,-0.6 -2,-0.2 4,-0.6 -0.531 25.4-129.6 -63.1 138.7 -11.4 5.5 15.9 41 283 A D G >4 S+ 0 0 37 -22,-2.4 3,-0.9 1,-0.2 -1,-0.1 0.880 102.1 61.9 -55.3 -41.6 -13.6 6.5 18.8 42 284 A H G 34 S+ 0 0 109 -23,-0.4 -1,-0.2 1,-0.3 -22,-0.1 0.751 116.9 25.9 -65.0 -28.3 -12.6 3.4 20.8 43 285 A S G <4 S+ 0 0 10 -3,-0.6 21,-2.6 199,-0.2 -1,-0.3 0.242 90.7 130.1-118.0 8.6 -8.9 4.2 21.0 44 286 A R E << -A 63 0A 24 -3,-0.9 2,-0.6 -4,-0.6 19,-0.3 -0.260 63.8-112.1 -65.7 152.4 -8.9 8.0 20.7 45 287 A V E - 0 0 0 17,-2.2 2,-0.6 15,-0.3 15,-0.5 -0.755 30.7-150.6 -80.2 122.4 -7.1 10.2 23.1 46 288 A I E -A 59 0A 85 -2,-0.6 2,-0.2 13,-0.1 13,-0.2 -0.871 13.5-129.2 -99.1 120.2 -9.6 12.2 25.2 47 289 A L - 0 0 4 11,-2.6 3,-0.4 -2,-0.6 2,-0.1 -0.502 25.8-136.0 -71.2 132.2 -8.4 15.6 26.4 48 290 A Q S S+ 0 0 112 -2,-0.2 3,-0.1 1,-0.2 -1,-0.1 -0.449 73.7 28.3 -87.1 157.7 -8.9 16.1 30.1 49 291 A G S S+ 0 0 87 1,-0.2 2,-0.2 -2,-0.1 -1,-0.2 0.655 84.4 135.7 74.0 18.6 -10.2 19.1 32.0 50 292 A R - 0 0 84 -3,-0.4 2,-0.6 1,-0.0 -1,-0.2 -0.567 60.2-110.0 -98.2 161.6 -12.4 20.4 29.1 51 293 A D > - 0 0 87 -2,-0.2 3,-2.4 1,-0.1 6,-0.3 -0.820 15.3-153.8 -96.7 117.4 -16.0 21.7 29.4 52 294 A S T 3 S+ 0 0 109 -2,-0.6 4,-0.2 1,-0.3 -1,-0.1 0.707 93.6 69.1 -64.6 -18.3 -18.5 19.3 27.8 53 295 A N T 3 S+ 0 0 135 2,-0.1 -1,-0.3 1,-0.1 -2,-0.0 0.596 84.5 77.3 -74.5 -11.8 -20.8 22.2 27.1 54 296 A I S X S- 0 0 98 -3,-2.4 3,-2.2 0, 0.0 4,-0.2 -0.897 99.6-119.5 -93.0 106.1 -18.2 23.4 24.6 55 297 A P T 3 S+ 0 0 80 0, 0.0 -2,-0.1 0, 0.0 -3,-0.1 -0.234 90.0 2.2 -56.2 127.9 -19.0 21.1 21.6 56 298 A G T > S+ 0 0 11 -4,-0.2 3,-2.3 1,-0.1 -4,-0.1 0.472 85.2 138.8 82.7 5.2 -15.9 19.0 20.7 57 299 A S T < + 0 0 12 -3,-2.2 -5,-0.1 -6,-0.3 -1,-0.1 0.750 67.3 53.2 -61.0 -24.7 -13.8 20.3 23.5 58 300 A D T 3 S+ 0 0 41 -4,-0.2 -11,-2.6 -8,-0.1 2,-0.3 0.377 88.2 117.5 -88.3 7.2 -12.3 16.9 24.4 59 301 A Y E < +A 46 0A 0 -3,-2.3 2,-0.3 -13,-0.2 -13,-0.1 -0.588 26.1 155.2 -93.2 135.3 -11.1 16.1 20.8 60 302 A I E - 0 0 7 -15,-0.5 2,-1.7 -2,-0.3 -15,-0.3 -0.979 46.9-116.9-141.6 147.1 -7.7 15.5 19.4 61 303 A N E S+ 0 0 1 -30,-0.4 19,-2.3 -2,-0.3 2,-0.3 -0.624 77.3 102.9 -82.4 84.7 -6.8 13.6 16.3 62 304 A A E - B 0 79A 0 -2,-1.7 -17,-2.2 17,-0.2 2,-0.4 -0.969 49.3-156.8-162.8 148.3 -4.8 10.9 18.0 63 305 A N E -AB 44 78A 0 15,-2.4 15,-2.8 -2,-0.3 -19,-0.2 -0.986 25.0-113.8-133.2 143.3 -5.1 7.3 19.1 64 306 A Y E - B 0 77A 63 -21,-2.6 2,-0.4 -2,-0.4 13,-0.3 -0.554 33.4-161.9 -62.4 135.8 -3.5 5.0 21.7 65 307 A I E - B 0 76A 0 11,-2.7 11,-2.5 -2,-0.2 2,-0.3 -0.993 9.6-178.5-127.3 125.2 -1.5 2.3 19.9 66 308 A K - 0 0 81 -2,-0.4 2,-1.5 9,-0.2 9,-0.1 -0.884 39.2-113.9-119.7 150.1 -0.4 -0.9 21.8 67 309 A N > + 0 0 14 7,-0.5 3,-1.0 -2,-0.3 6,-0.1 -0.679 45.2 175.0 -79.3 89.3 1.6 -3.9 20.7 68 310 A Q T 3 + 0 0 113 -2,-1.5 -1,-0.2 1,-0.3 167,-0.0 0.285 59.3 83.5 -94.0 8.5 -1.5 -6.2 21.0 69 311 A L T 3 0 0 79 166,-0.0 -1,-0.3 -3,-0.0 -2,-0.1 0.597 360.0 360.0 -77.0 -11.5 -0.0 -9.4 19.7 70 312 A L < 0 0 107 -3,-1.0 -4,-0.0 0, 0.0 3,-0.0 -0.804 360.0 360.0 -99.8 360.0 1.2 -9.6 23.2 71 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 72 317 A N 0 0 206 0, 0.0 3,-0.1 0, 0.0 2,-0.0 0.000 360.0 360.0 360.0 77.7 5.7 -5.0 29.4 73 318 A A - 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0 0 23 -3,-0.1 3,-1.7 -52,-0.1 4,-0.7 -0.759 39.2-104.5 -99.2 161.7 -2.4 22.7 13.3 84 329 A E G >4 S+ 0 0 151 -2,-0.3 3,-0.8 1,-0.3 4,-0.3 0.907 125.5 52.4 -48.9 -41.3 -2.1 26.2 14.5 85 330 A A G 34 S+ 0 0 77 1,-0.2 -1,-0.3 -55,-0.2 4,-0.2 0.605 111.7 44.9 -75.3 -13.3 -5.4 25.6 16.2 86 331 A T G <> S+ 0 0 6 -3,-1.7 4,-2.4 2,-0.1 -1,-0.2 0.316 76.1 101.7-117.3 9.4 -4.4 22.4 17.9 87 332 A V H S+ 0 0 77 -4,-0.3 4,-2.3 1,-0.2 -1,-0.2 0.905 110.2 54.0 -63.4 -39.5 -2.4 23.7 22.9 89 334 A D H > S+ 0 0 17 2,-0.2 4,-2.4 1,-0.2 -1,-0.2 0.891 106.0 54.1 -58.3 -43.1 -4.4 20.5 22.5 90 335 A F H X S+ 0 0 1 -4,-2.4 4,-2.7 1,-0.2 -2,-0.2 0.933 109.2 46.3 -59.4 -47.4 -1.2 18.7 21.7 91 336 A W H X S+ 0 0 2 -4,-2.0 4,-2.8 2,-0.2 -1,-0.2 0.877 109.4 54.9 -64.3 -36.5 0.5 19.9 24.9 92 337 A Q H X S+ 0 0 19 -4,-2.3 4,-2.8 2,-0.2 5,-0.3 0.932 110.0 47.9 -58.4 -44.3 -2.5 19.0 26.9 93 338 A M H X S+ 0 0 0 -4,-2.4 4,-1.9 1,-0.2 6,-0.3 0.953 111.2 48.9 -61.4 -51.7 -2.2 15.5 25.5 94 339 A A H <>S+ 0 0 0 -4,-2.7 5,-1.7 1,-0.2 4,-0.5 0.920 115.7 44.6 -54.8 -45.8 1.5 15.3 26.2 95 340 A W H ><5S+ 0 0 31 -4,-2.8 3,-1.2 1,-0.2 -2,-0.2 0.948 113.6 46.4 -64.2 -50.5 1.0 16.5 29.8 96 341 A Q H 3<5S+ 0 0 27 -4,-2.8 -1,-0.2 1,-0.3 -2,-0.2 0.799 114.2 49.0 -68.5 -26.5 -2.0 14.4 30.8 97 342 A E T 3<5S- 0 0 29 -4,-1.9 -1,-0.3 -5,-0.3 -2,-0.2 0.494 104.5-127.5 -89.6 -4.5 -0.5 11.2 29.3 98 343 A N T < 5 + 0 0 39 -3,-1.2 97,-2.8 -4,-0.5 -3,-0.2 0.803 43.4 175.8 61.3 29.8 2.9 11.7 31.1 99 344 A S < + 0 0 0 -5,-1.7 -1,-0.2 -6,-0.3 98,-0.1 -0.464 17.5 176.2 -67.0 133.4 4.7 11.3 27.8 100 345 A R + 0 0 58 95,-0.4 58,-3.3 1,-0.2 2,-0.4 0.463 65.1 54.5-116.7 -8.0 8.4 11.9 28.1 101 346 A V E -d 158 0A 0 95,-0.3 97,-2.0 56,-0.2 2,-0.4 -0.995 60.8-172.8-130.2 126.0 9.4 11.1 24.6 102 347 A I E -de 159 198A 0 56,-2.5 58,-3.2 -2,-0.4 2,-0.6 -0.980 6.8-160.8-118.8 130.7 8.0 12.8 21.5 103 348 A V E -de 160 199A 2 95,-3.5 97,-2.5 -2,-0.4 2,-0.5 -0.934 6.6-173.9-116.6 112.7 8.9 11.5 18.0 104 349 A M E -de 161 200A 8 56,-3.2 58,-3.1 -2,-0.6 97,-0.2 -0.922 6.5-172.1-110.1 122.0 8.3 13.9 15.1 105 350 A T + 0 0 0 95,-2.2 2,-0.3 -2,-0.5 60,-0.2 0.320 59.3 74.3-100.0 6.7 8.9 12.4 11.7 106 351 A T S S- 0 0 29 94,-0.2 2,-0.2 58,-0.1 58,-0.1 -0.857 74.3-122.8-119.9 152.4 8.6 15.6 9.6 107 352 A R 0 0 109 -2,-0.3 56,-0.1 58,-0.2 -2,-0.1 -0.484 360.0 360.0 -77.7 164.2 10.7 18.7 8.9 108 353 A E 0 0 129 -2,-0.2 -1,-0.1 55,-0.0 55,-0.0 -0.422 360.0 360.0 -66.0 360.0 9.1 22.1 9.7 109 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 110 362 A V 0 0 73 0, 0.0 -28,-0.2 0, 0.0 -2,-0.0 0.000 360.0 360.0 360.0 103.9 3.9 24.2 12.7 111 363 A P - 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