==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=19-APR-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE/HYDROLASE INHIBITOR 15-NOV-12 4HZT . COMPND 2 MOLECULE: BETA-SECRETASE 1; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR N.YAO,E.BRECHT . 393 2 3 2 1 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 17934.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 270 68.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 18 4.6 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 114 29.0 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 3 0.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 3 0.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 52 13.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 40 10.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 31 7.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 4 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 5 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 5 2 3 3 4 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 1 0 2 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 58 A G 0 0 36 0, 0.0 95,-0.1 0, 0.0 96,-0.0 0.000 360.0 360.0 360.0 55.1 13.9 -10.8 37.3 2 59 A S >> - 0 0 82 93,-0.1 3,-0.9 1,-0.1 4,-0.5 -0.030 360.0 -83.0 -63.1 179.9 16.0 -13.8 38.5 3 60 A F H >> S+ 0 0 69 1,-0.3 4,-1.3 2,-0.2 3,-0.8 0.797 130.2 63.9 -70.0 -29.9 15.9 -16.9 36.1 4 61 A V H 34 S+ 0 0 117 1,-0.2 -1,-0.3 2,-0.2 3,-0.2 0.866 99.6 55.4 -52.4 -37.5 12.6 -18.2 37.6 5 62 A E H <4 S+ 0 0 114 -3,-0.9 -1,-0.2 1,-0.2 -2,-0.2 0.781 109.4 46.7 -65.4 -24.4 11.1 -14.9 36.2 6 63 A M H X< S+ 0 0 4 -3,-0.8 3,-1.4 -4,-0.5 163,-0.6 0.591 83.0 107.8 -97.7 -16.7 12.4 -15.8 32.6 7 64 A V T 3< S+ 0 0 51 -4,-1.3 161,-0.1 1,-0.2 163,-0.0 -0.446 91.1 10.7 -59.9 136.1 11.3 -19.5 32.5 8 65 A D T 3 S+ 0 0 87 149,-0.1 -1,-0.2 -2,-0.1 160,-0.2 0.714 83.2 134.5 69.4 23.3 8.3 -19.9 30.1 9 66 A N < + 0 0 15 -3,-1.4 12,-0.6 84,-0.1 2,-0.4 0.416 50.1 85.8 -87.3 7.7 8.6 -16.3 28.6 10 67 A L E +AB 20 167A 0 157,-2.4 157,-1.2 10,-0.1 2,-0.3 -0.881 48.5 170.0-109.9 139.9 8.2 -17.6 25.0 11 68 A R E +AB 19 166A 104 8,-2.4 8,-3.6 -2,-0.4 2,-0.3 -0.935 10.9 135.1-134.3 159.8 5.1 -18.2 23.0 12 69 A G E - B 0 165A 3 153,-1.5 153,-2.3 -2,-0.3 2,-0.3 -0.983 45.8 -94.1-172.5-175.7 4.3 -19.0 19.3 13 70 A K E > - B 0 164A 45 4,-0.5 3,-2.7 -2,-0.3 151,-0.2 -0.924 54.2 -92.2-113.3 146.8 2.4 -21.0 16.7 14 71 A S T 3 S+ 0 0 32 149,-2.5 213,-0.0 -2,-0.3 4,-0.0 -0.335 115.0 15.7 -57.8 127.7 4.0 -24.1 15.1 15 72 A G T 3 S+ 0 0 45 211,-0.1 -1,-0.3 212,-0.1 212,-0.1 0.358 113.6 76.9 92.2 -3.8 5.8 -22.9 11.9 16 73 A Q S < S- 0 0 34 -3,-2.7 -2,-0.1 1,-0.4 -3,-0.1 -0.016 93.9-120.4-132.7 30.9 5.8 -19.2 12.8 17 74 A G - 0 0 15 -5,-0.1 -4,-0.5 -4,-0.1 2,-0.4 -0.004 32.2 -64.6 74.3-169.2 8.6 -19.0 15.4 18 75 A Y - 0 0 6 17,-0.4 17,-3.7 206,-0.3 2,-0.3 -0.970 42.3-162.8-124.4 136.1 8.8 -18.0 19.0 19 76 A Y E -AC 11 34A 29 -8,-3.6 -8,-2.4 -2,-0.4 2,-0.3 -0.893 5.7-157.6-122.7 155.1 8.2 -14.5 20.5 20 77 A V E -AC 10 33A 1 13,-2.4 13,-3.0 -2,-0.3 2,-0.3 -0.885 31.3-105.1-121.1 147.3 9.0 -12.8 23.8 21 78 A E E + C 0 32A 57 -12,-0.6 72,-0.4 -2,-0.3 2,-0.3 -0.601 43.2 173.6 -72.1 135.4 7.2 -9.8 25.2 22 79 A M E - C 0 31A 0 9,-2.6 9,-2.9 -2,-0.3 2,-0.4 -0.980 22.1-141.3-133.9 158.8 9.0 -6.5 25.0 23 80 A T E -DC 90 30A 18 67,-2.7 67,-1.6 -2,-0.3 2,-0.4 -0.903 14.5-167.5-115.9 146.8 8.2 -3.0 25.8 24 81 A V E > -DC 89 29A 0 5,-1.8 5,-2.8 -2,-0.4 65,-0.2 -0.995 46.3 -5.2-130.5 139.1 9.2 0.0 23.7 25 82 A G T 5S- 0 0 5 63,-2.5 36,-0.1 -2,-0.4 4,-0.1 0.062 88.1 -42.3 83.4-179.8 9.0 3.7 24.6 26 83 A S T 5S+ 0 0 26 1,-0.2 36,-2.8 2,-0.2 37,-0.4 -0.994 129.9 30.6-138.6 124.0 7.7 5.7 27.5 27 84 A P T 5S- 0 0 97 0, 0.0 -1,-0.2 0, 0.0 -3,-0.1 0.642 119.8-105.0 -63.5 155.5 5.1 5.1 28.6 28 85 A P T 5 - 0 0 87 0, 0.0 2,-0.6 0, 0.0 -3,-0.2 -0.247 27.3-156.1 -63.2 131.8 5.8 1.4 27.6 29 86 A Q E < -C 24 0A 29 -5,-2.8 -5,-1.8 -4,-0.1 2,-0.4 -0.928 18.4-140.0-101.9 120.8 4.1 -0.0 24.6 30 87 A T E +C 23 0A 52 -2,-0.6 2,-0.3 -7,-0.2 -7,-0.2 -0.654 28.9 169.4 -88.7 130.9 4.0 -3.9 25.0 31 88 A L E -C 22 0A 2 -9,-2.9 -9,-2.6 -2,-0.4 2,-0.6 -0.960 36.6-118.8-135.3 156.1 4.6 -5.9 21.8 32 89 A N E -C 21 0A 24 -2,-0.3 88,-3.4 -11,-0.2 89,-0.9 -0.867 35.6-164.2 -96.7 124.6 5.3 -9.6 21.0 33 90 A I E -Ce 20 121A 0 -13,-3.0 -13,-2.4 -2,-0.6 89,-0.2 -0.922 18.1-122.6-123.5 120.6 8.6 -9.9 19.3 34 91 A L E -Ce 19 122A 15 87,-2.7 89,-3.1 -2,-0.5 2,-0.7 -0.404 23.6-129.4 -58.8 130.2 10.0 -12.9 17.3 35 92 A V E + e 0 123A 2 -17,-3.7 2,-0.5 87,-0.2 -17,-0.4 -0.756 34.2 178.5 -84.8 112.6 13.2 -14.3 18.7 36 93 A D E > + e 0 124A 12 87,-2.4 89,-2.7 -2,-0.7 3,-1.0 -0.876 23.8 174.4-126.4 96.0 15.6 -14.5 15.7 37 94 A T T 3 S+ 0 0 0 -2,-0.5 157,-0.4 1,-0.2 185,-0.1 0.501 79.7 69.8 -77.9 2.9 19.2 -15.7 16.1 38 95 A G T 3 S+ 0 0 13 155,-0.1 2,-0.3 88,-0.1 -1,-0.2 0.390 100.9 36.7-104.9 9.5 19.5 -15.5 12.3 39 96 A S < - 0 0 17 -3,-1.0 87,-3.1 84,-0.2 92,-0.1 -0.904 63.5-140.2-148.8 179.2 19.4 -11.7 11.9 40 97 A S + 0 0 2 90,-0.4 2,-0.4 -2,-0.3 100,-0.2 0.314 62.8 94.8-134.7 9.6 20.7 -8.6 13.7 41 98 A N - 0 0 12 98,-0.1 83,-1.5 89,-0.1 2,-0.7 -0.871 58.8-142.6-103.7 144.0 18.1 -5.9 13.6 42 99 A F E +F 123 0A 7 -2,-0.4 62,-2.5 81,-0.2 2,-0.4 -0.890 37.5 167.7 -96.9 117.3 15.5 -5.0 16.1 43 100 A A E -Fg 122 104A 0 79,-2.4 79,-3.8 -2,-0.7 2,-0.4 -0.998 14.8-171.2-138.8 135.7 12.5 -4.0 14.0 44 101 A V E -Fg 121 105A 0 60,-2.9 62,-3.2 -2,-0.4 77,-0.3 -0.981 35.8-100.5-129.6 140.9 8.8 -3.5 15.0 45 102 A G E + g 0 106A 1 75,-3.8 11,-3.0 -2,-0.4 62,-0.1 -0.295 41.5 175.2 -50.7 133.2 5.6 -2.9 13.0 46 103 A A + 0 0 10 60,-2.2 12,-0.2 9,-0.3 -1,-0.1 0.142 55.6 42.2-139.1 17.6 5.1 0.9 13.3 47 104 A A S S- 0 0 30 59,-0.2 -1,-0.1 7,-0.1 9,-0.1 -0.963 97.6 -69.8-158.1 161.0 2.0 1.5 11.1 48 105 A P + 0 0 102 0, 0.0 -2,-0.1 0, 0.0 5,-0.1 -0.160 48.2 174.5 -60.6 149.0 -1.3 -0.2 10.5 49 106 A H > - 0 0 45 3,-0.5 3,-1.9 -4,-0.1 59,-0.0 -0.978 40.9-119.4-148.4 143.5 -1.4 -3.6 8.8 50 107 A P T 3 S+ 0 0 120 0, 0.0 -1,-0.1 0, 0.0 0, 0.0 0.780 114.9 46.0 -55.1 -29.2 -4.4 -5.9 8.2 51 108 A F T 3 S+ 0 0 94 62,-0.1 2,-0.4 64,-0.1 67,-0.3 0.199 105.7 70.4-100.3 12.1 -2.7 -8.7 10.2 52 109 A L < - 0 0 25 -3,-1.9 -3,-0.5 1,-0.1 3,-0.1 -0.972 46.5-179.4-123.4 145.6 -1.6 -6.5 13.2 53 110 A H S S+ 0 0 160 -2,-0.4 2,-0.3 1,-0.2 -1,-0.1 0.508 78.1 36.6-120.1 -11.4 -3.8 -4.9 15.8 54 111 A R + 0 0 79 -7,-0.1 2,-0.3 -5,-0.0 -1,-0.2 -0.950 64.3 161.2-129.5 166.0 -1.0 -3.3 17.7 55 112 A Y - 0 0 62 -2,-0.3 2,-0.5 -9,-0.1 -9,-0.3 -0.963 47.9 -75.0-169.9 154.2 2.2 -1.6 16.5 56 113 A Y - 0 0 2 -11,-3.0 2,-0.8 -2,-0.3 3,-0.1 -0.563 37.1-160.3 -65.2 122.4 4.8 0.8 17.8 57 114 A Q > - 0 0 59 -2,-0.5 3,-1.9 1,-0.2 4,-0.3 -0.826 5.8-171.7-105.9 99.4 3.5 4.4 17.8 58 115 A R G > S+ 0 0 44 -2,-0.8 3,-1.8 1,-0.3 6,-0.3 0.875 82.8 63.1 -61.2 -37.9 6.6 6.6 17.9 59 116 A Q G 3 S+ 0 0 135 1,-0.3 -1,-0.3 -3,-0.1 -2,-0.0 0.620 100.0 53.4 -59.2 -19.5 4.4 9.7 18.4 60 117 A L G < S+ 0 0 91 -3,-1.9 2,-0.7 -33,-0.0 -1,-0.3 0.369 91.3 89.6 -96.0 -0.1 3.2 8.3 21.8 61 118 A S X - 0 0 10 -3,-1.8 3,-0.9 -4,-0.3 -36,-0.1 -0.891 55.8-167.3-101.8 112.5 6.7 7.7 23.1 62 119 A S T 3 S+ 0 0 103 -36,-2.8 -1,-0.1 -2,-0.7 -3,-0.0 0.672 91.0 52.5 -65.0 -16.1 8.3 10.7 25.0 63 120 A T T 3 S+ 0 0 31 -37,-0.4 -1,-0.2 25,-0.1 2,-0.2 0.422 81.4 119.1-104.0 -0.7 11.7 9.0 24.8 64 121 A Y < - 0 0 56 -3,-0.9 2,-0.4 -6,-0.3 23,-0.2 -0.415 40.1-172.5 -70.0 135.6 11.7 8.3 21.1 65 122 A R E -H 86 0A 149 21,-2.5 21,-2.5 -2,-0.2 2,-0.4 -0.997 18.3-135.0-131.1 129.6 14.5 9.9 19.0 66 123 A D E -H 85 0A 48 -2,-0.4 19,-0.3 19,-0.2 18,-0.0 -0.643 7.3-162.0 -83.4 131.7 14.6 9.8 15.2 67 124 A L E - 0 0 75 17,-2.1 18,-0.2 -2,-0.4 -1,-0.1 0.461 32.2-133.4 -89.5 -1.4 17.9 8.9 13.6 68 125 A R E + 0 0 207 16,-0.5 2,-0.3 1,-0.2 17,-0.1 0.885 66.8 115.2 53.6 47.4 16.6 10.3 10.2 69 126 A K E -H 84 0A 96 15,-0.5 15,-3.2 2,-0.0 -2,-0.2 -0.982 55.0-142.7-151.4 132.1 17.9 7.3 8.2 70 127 A G E -H 83 0A 50 -2,-0.3 2,-0.3 13,-0.2 13,-0.2 -0.458 10.0-160.0 -91.3 166.5 15.8 4.7 6.3 71 128 A V E -H 82 0A 11 11,-2.2 11,-2.5 -2,-0.2 2,-0.4 -0.975 3.9-164.5-150.6 141.7 16.5 1.0 6.0 72 129 A Y E -H 81 0A 148 -2,-0.3 9,-0.2 9,-0.2 -2,-0.0 -0.989 7.1-171.9-130.9 121.9 15.3 -1.5 3.4 73 130 A V E -H 80 0A 10 7,-3.1 7,-2.0 -2,-0.4 2,-0.3 -0.874 4.8-168.2-125.7 100.7 15.6 -5.3 4.2 74 131 A P E -H 79 0A 56 0, 0.0 2,-0.3 0, 0.0 5,-0.3 -0.639 3.2-171.3 -92.8 149.4 14.8 -7.7 1.4 75 132 A Y E > -H 78 0A 82 3,-3.2 3,-0.7 -2,-0.3 -2,-0.0 -0.856 39.6-113.1-121.4 167.5 14.3 -11.4 1.8 76 133 A T T 3 S+ 0 0 140 -2,-0.3 -1,-0.1 1,-0.2 3,-0.1 0.895 122.2 43.6 -62.4 -30.3 13.9 -14.1 -0.9 77 134 A Q T 3 S- 0 0 145 -3,-0.0 2,-0.3 1,-0.0 -1,-0.2 0.393 131.7 -51.7 -98.8 -4.3 10.4 -14.4 0.5 78 135 A G E < -H 75 0A 17 -3,-0.7 -3,-3.2 2,-0.0 2,-0.3 -0.967 58.8-112.3 158.4-155.9 9.3 -10.7 0.9 79 136 A K E -HI 74 110A 37 31,-2.0 31,-2.7 -2,-0.3 2,-0.3 -0.986 6.9-150.6-163.6 162.1 10.7 -7.6 2.6 80 137 A W E -HI 73 109A 4 -7,-2.0 -7,-3.1 -2,-0.3 2,-0.3 -0.973 16.6-177.6-132.0 154.7 10.3 -5.0 5.4 81 138 A E E +HI 72 108A 47 27,-2.1 26,-2.0 -2,-0.3 27,-1.5 -0.969 15.0 137.1-144.2 163.7 11.4 -1.4 5.2 82 139 A G E -HI 71 106A 7 -11,-2.5 -11,-2.2 -2,-0.3 2,-0.4 -0.952 46.7 -70.6 179.8-167.9 11.4 1.5 7.8 83 140 A E E -HI 70 105A 87 22,-1.8 22,-2.6 -2,-0.3 -13,-0.2 -0.939 41.2-130.4-121.8 127.3 12.8 4.4 9.6 84 141 A L E +HI 69 104A 0 -15,-3.2 -17,-2.1 -2,-0.4 -15,-0.5 -0.577 41.7 137.1 -80.5 142.4 15.7 4.0 12.2 85 142 A G E -HI 66 103A 2 18,-1.6 18,-2.5 -19,-0.3 2,-0.3 -0.890 42.3-111.8-156.7-169.3 15.5 5.6 15.6 86 143 A T E +HI 65 102A 17 -21,-2.5 -21,-2.5 -2,-0.3 2,-0.3 -0.967 33.6 159.5-131.9 153.5 16.3 4.8 19.3 87 144 A D E - I 0 101A 0 14,-1.8 14,-2.7 -2,-0.3 2,-0.3 -0.954 46.7 -78.8-158.3 172.7 14.0 4.4 22.3 88 145 A L E - I 0 100A 53 -2,-0.3 -63,-2.5 12,-0.2 2,-0.4 -0.620 48.9-170.1 -77.5 139.5 13.9 2.8 25.7 89 146 A V E +DI 24 99A 1 10,-2.4 10,-2.8 -2,-0.3 2,-0.3 -0.994 10.8 173.6-141.0 138.4 13.4 -1.0 25.6 90 147 A S E -DI 23 98A 25 -67,-1.6 -67,-2.7 -2,-0.4 8,-0.1 -0.928 27.8-139.1-140.5 157.0 12.7 -3.5 28.3 91 148 A I > - 0 0 9 6,-0.5 3,-1.7 4,-0.5 6,-0.2 -0.952 16.3-159.5-119.8 100.4 11.8 -7.2 28.5 92 149 A P T 3 S+ 0 0 55 0, 0.0 -1,-0.1 0, 0.0 -70,-0.1 0.784 92.8 38.2 -60.2 -32.5 9.1 -7.6 31.2 93 150 A H T 3 S+ 0 0 94 -72,-0.4 -84,-0.1 -84,-0.1 3,-0.1 -0.318 116.4 60.6-104.7 45.5 9.8 -11.3 31.7 94 151 A G S < S- 0 0 4 -3,-1.7 76,-0.1 1,-0.2 -87,-0.0 -0.549 104.2 -20.2-142.9-150.7 13.6 -11.0 31.3 95 152 A P - 0 0 13 0, 0.0 2,-2.6 0, 0.0 -4,-0.5 -0.282 65.5-112.3 -70.6 151.2 16.3 -9.0 33.3 96 153 A N S S+ 0 0 150 -95,-0.1 2,-0.3 -6,-0.1 -6,-0.0 -0.356 80.9 105.4 -83.3 60.7 15.1 -6.1 35.4 97 154 A V - 0 0 43 -2,-2.6 -6,-0.5 -6,-0.2 2,-0.4 -0.899 55.3-148.2-138.7 158.0 16.9 -3.5 33.2 98 155 A T E - I 0 90A 84 -2,-0.3 2,-0.3 -8,-0.1 -8,-0.2 -0.990 20.9-173.9-127.8 139.2 15.9 -0.8 30.6 99 156 A V E - I 0 89A 3 -10,-2.8 -10,-2.4 -2,-0.4 2,-0.7 -0.967 30.2-119.1-135.8 157.2 18.2 0.1 27.7 100 157 A R E + I 0 88A 44 -2,-0.3 2,-0.3 -12,-0.2 -12,-0.2 -0.845 48.1 172.6 -93.5 117.8 18.4 2.6 24.9 101 158 A A E - I 0 87A 1 -14,-2.7 -14,-1.8 -2,-0.7 2,-0.2 -0.899 38.8 -99.7-125.3 155.6 18.4 0.6 21.7 102 159 A N E - I 0 86A 29 36,-0.5 2,-0.4 -2,-0.3 -16,-0.3 -0.507 41.2-171.8 -65.1 137.3 18.2 1.0 18.0 103 160 A I E - I 0 85A 3 -18,-2.5 -18,-1.6 -2,-0.2 2,-0.6 -0.992 17.2-151.5-135.2 124.0 14.7 0.4 16.7 104 161 A A E -gI 43 84A 1 -62,-2.5 -60,-2.9 -2,-0.4 2,-0.9 -0.869 15.9-147.3 -90.4 122.7 13.7 0.1 13.0 105 162 A A E -gI 44 83A 1 -22,-2.6 -22,-1.8 -2,-0.6 2,-0.5 -0.824 17.0-134.9 -93.0 115.2 10.1 1.2 12.8 106 163 A I E +gI 45 82A 5 -62,-3.2 -60,-2.2 -2,-0.9 -24,-0.3 -0.566 31.5 171.3 -77.8 117.2 8.6 -0.9 10.0 107 164 A T E + 0 0 42 -26,-2.0 2,-0.3 -2,-0.5 -25,-0.2 0.690 67.3 12.0 -98.1 -24.6 6.6 1.4 7.8 108 165 A E E + I 0 81A 115 -27,-1.5 -27,-2.1 2,-0.0 -1,-0.3 -0.988 66.3 167.7-150.4 144.9 5.9 -1.0 4.8 109 166 A S E - I 0 80A 18 -2,-0.3 2,-0.4 -29,-0.2 -29,-0.2 -0.981 21.0-146.5-156.6 164.5 6.4 -4.7 4.4 110 167 A D E S- I 0 79A 78 -31,-2.7 -31,-2.0 -2,-0.3 -2,-0.0 -0.987 80.7 -16.1-139.8 120.5 5.4 -7.6 2.1 111 168 A K S S+ 0 0 180 -2,-0.4 3,-0.1 -33,-0.2 -31,-0.1 0.705 106.4 103.9 60.0 26.7 4.8 -11.1 3.1 112 169 A F S S+ 0 0 23 1,-0.3 2,-0.7 -33,-0.2 -1,-0.1 0.862 70.8 51.1-102.6 -58.9 6.5 -10.5 6.5 113 170 A F S S- 0 0 10 7,-0.1 -1,-0.3 5,-0.0 2,-0.2 -0.760 82.9-156.0 -81.0 112.8 3.5 -10.2 8.9 114 171 A I > - 0 0 85 -2,-0.7 3,-1.3 -3,-0.1 4,-0.3 -0.600 30.6 -83.3 -95.7 148.7 1.2 -13.3 8.3 115 172 A N T 3 S- 0 0 118 1,-0.2 -1,-0.1 -2,-0.2 -64,-0.1 -0.272 107.9 -12.3 -49.5 113.2 -2.5 -13.7 9.1 116 173 A G T 3 S+ 0 0 33 -65,-0.2 -1,-0.2 1,-0.1 -64,-0.1 0.728 86.5 126.0 62.6 38.4 -2.7 -14.6 12.8 117 174 A S < - 0 0 4 -3,-1.3 -104,-0.2 -66,-0.2 -2,-0.1 0.700 63.0-137.7 -90.2 -25.1 0.9 -15.5 13.9 118 175 A N + 0 0 71 -4,-0.3 2,-0.3 -67,-0.3 -86,-0.1 0.404 60.3 115.1 81.6 13.0 0.7 -12.9 16.8 119 176 A W - 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