==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=4-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER GROWTH FACTOR/GROWTH FACTOR RECEPTOR 20-APR-01 1II4 . COMPND 2 MOLECULE: HEPARIN-BINDING GROWTH FACTOR 2; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,D.M.ORNITZ, . 1336 12 8 4 4 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 56691.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 876 65.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 44 3.3 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 462 34.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 12 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 20 1.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 24 1.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 8 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 158 11.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 136 10.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 24 1.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 12 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 23 20 8 16 12 12 0 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 12 4 0 8 0 0 0 0 0 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 21 A F 0 0 162 0, 0.0 642,-0.1 0, 0.0 640,-0.0 0.000 360.0 360.0 360.0 146.2 0.7 -11.3 -10.6 2 22 A P - 0 0 20 0, 0.0 638,-0.0 0, 0.0 641,-0.0 -0.228 360.0-113.0 -54.4 143.4 0.2 -10.1 -6.9 3 23 A P S S+ 0 0 120 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.922 77.7 93.5 -43.2 -83.4 -3.5 -10.3 -5.8 4 24 A G - 0 0 48 1,-0.1 2,-0.4 2,-0.1 128,-0.0 0.446 63.2-135.0 -17.5 145.8 -4.8 -6.8 -5.2 5 25 A H > - 0 0 42 4,-0.1 3,-1.8 1,-0.1 -1,-0.1 -0.950 14.9-126.9-115.5 134.0 -6.7 -4.8 -7.9 6 26 A F T 3 S+ 0 0 3 -2,-0.4 38,-0.2 1,-0.3 695,-0.1 0.656 104.9 52.1 -51.1 -26.0 -5.9 -1.1 -8.5 7 27 A K T 3 S+ 0 0 60 694,-0.1 -1,-0.3 36,-0.1 695,-0.1 0.684 86.7 101.8 -89.7 -13.1 -9.5 0.2 -8.2 8 28 A D S < S- 0 0 79 -3,-1.8 36,-0.3 1,-0.1 34,-0.0 -0.287 83.8-101.3 -67.3 148.9 -10.1 -1.4 -4.8 9 29 A P - 0 0 50 0, 0.0 124,-0.7 0, 0.0 2,-0.3 -0.351 47.6-162.8 -66.8 157.0 -10.0 0.7 -1.7 10 30 A K E -AB 42 132A 27 32,-3.2 32,-3.6 122,-0.2 2,-0.4 -0.876 21.9-124.7-139.2 170.3 -6.7 0.4 0.3 11 31 A R E - B 0 131A 38 120,-2.6 120,-2.6 -2,-0.3 2,-0.8 -0.910 23.2-140.2-113.5 140.2 -5.0 1.0 3.6 12 32 A L E - B 0 130A 1 -2,-0.4 9,-2.5 28,-0.4 2,-0.4 -0.854 18.3-162.8-108.0 100.8 -1.8 3.0 3.6 13 33 A Y E -CB 20 129A 0 116,-2.2 116,-3.2 -2,-0.8 2,-0.5 -0.667 8.1-144.5 -84.2 129.9 0.6 1.4 6.1 14 34 A C E >> -CB 19 128A 0 5,-3.0 4,-1.4 -2,-0.4 5,-0.6 -0.835 8.2-146.7-100.8 123.7 3.5 3.6 7.2 15 35 A K T 45S+ 0 0 7 112,-2.6 2,-1.2 -2,-0.5 3,-0.2 0.900 83.9 86.5 -50.2 -43.4 6.9 2.0 7.9 16 36 A N T >45S- 0 0 28 108,-0.9 3,-0.6 111,-0.4 -1,-0.1 -0.440 122.2 -24.4 -65.7 94.6 7.5 4.5 10.6 17 37 A G T 345S- 0 0 10 -2,-1.2 -1,-0.3 1,-0.2 -2,-0.2 0.248 100.2 -91.7 88.5 -14.5 5.9 3.0 13.6 18 38 A G T 3<5S+ 0 0 2 -4,-1.4 2,-0.3 1,-0.2 -1,-0.2 0.846 73.3 157.4 76.4 33.9 3.5 0.8 11.7 19 39 A F E < < -C 14 0A 18 -5,-0.6 -5,-3.0 -3,-0.6 2,-0.4 -0.723 38.5-134.0 -94.3 144.2 0.6 3.2 11.6 20 40 A F E -CD 13 32A 3 12,-4.2 12,-1.9 -2,-0.3 2,-0.3 -0.761 32.7-106.9 -92.2 138.8 -2.1 3.1 9.0 21 41 A L E - D 0 31A 1 -9,-2.5 2,-0.4 -2,-0.4 -9,-0.4 -0.512 41.8-162.5 -67.8 128.3 -3.0 6.5 7.5 22 42 A R E - D 0 30A 50 8,-4.0 8,-2.2 -2,-0.3 2,-0.6 -0.960 14.7-161.7-121.6 133.7 -6.3 7.7 8.9 23 43 A I E - D 0 29A 0 16,-2.8 36,-0.6 -2,-0.4 6,-0.2 -0.925 17.8-147.9-116.3 108.6 -8.7 10.3 7.7 24 44 A H > - 0 0 12 4,-2.9 3,-2.2 -2,-0.6 49,-0.1 -0.358 21.8-117.7 -74.1 151.1 -11.3 11.6 10.2 25 45 A P T 3 S+ 0 0 63 0, 0.0 -1,-0.1 0, 0.0 -2,-0.0 0.760 115.4 55.2 -58.2 -28.4 -14.8 12.8 9.4 26 46 A D T 3 S- 0 0 83 2,-0.1 -2,-0.1 35,-0.0 47,-0.0 0.262 127.4 -98.1 -90.6 12.8 -14.0 16.2 10.7 27 47 A G S < S+ 0 0 8 -3,-2.2 46,-2.7 1,-0.3 2,-0.1 0.402 76.2 145.3 89.2 -4.5 -11.0 16.5 8.4 28 48 A R - 0 0 131 44,-0.2 -4,-2.9 -5,-0.1 2,-0.4 -0.422 33.4-155.1 -67.8 143.3 -8.4 15.5 11.0 29 49 A V E +D 23 0A 6 42,-0.5 84,-0.5 -6,-0.2 2,-0.2 -0.980 33.4 113.0-126.6 131.0 -5.5 13.5 9.6 30 50 A D E -DE 22 112A 15 -8,-2.2 -8,-4.0 -2,-0.4 2,-0.3 -0.873 51.3 -91.8-165.9-163.0 -3.3 11.0 11.6 31 51 A G E -D 21 0A 7 80,-2.4 2,-0.3 -10,-0.3 -10,-0.2 -0.952 26.7-178.9-134.8 153.7 -2.3 7.4 11.9 32 52 A V E -D 20 0A 15 -12,-1.9 -12,-4.2 -2,-0.3 79,-0.1 -0.923 26.6-139.6-142.2 165.9 -3.5 4.4 14.0 33 53 A R S S+ 0 0 82 -2,-0.3 2,-1.0 -14,-0.2 -1,-0.1 0.630 71.2 103.2-104.8 -14.4 -2.5 0.7 14.3 34 54 A E > - 0 0 120 1,-0.2 3,-2.4 -14,-0.1 -1,-0.0 -0.553 54.9-161.5 -76.7 102.6 -5.9 -0.9 14.6 35 55 A K T 3 S+ 0 0 36 -2,-1.0 -1,-0.2 1,-0.3 5,-0.1 0.714 87.9 63.1 -53.4 -23.8 -6.6 -2.4 11.2 36 56 A S T 3 S+ 0 0 95 3,-0.0 -1,-0.3 -3,-0.0 4,-0.1 0.698 71.2 119.9 -78.2 -18.0 -10.3 -2.5 12.1 37 57 A D X - 0 0 20 -3,-2.4 3,-1.0 1,-0.2 4,-0.1 -0.226 59.3-147.2 -49.2 124.8 -10.5 1.3 12.3 38 58 A P G > S+ 0 0 79 0, 0.0 3,-0.7 0, 0.0 20,-0.5 0.643 88.6 67.9 -72.8 -13.8 -13.1 2.3 9.6 39 59 A H G 3 S+ 0 0 43 1,-0.2 -16,-2.8 19,-0.1 -2,-0.1 0.169 87.5 66.7 -94.0 19.3 -11.4 5.6 8.8 40 60 A I G < + 0 0 0 -3,-1.0 2,-0.8 -18,-0.2 -28,-0.4 0.366 67.6 106.3-114.9 -1.3 -8.3 4.1 7.2 41 61 A K < - 0 0 24 -3,-0.7 16,-2.2 -30,-0.1 17,-0.5 -0.736 56.6-175.5 -80.4 113.7 -10.0 2.6 4.2 42 62 A L E -AF 10 56A 0 -32,-3.6 -32,-3.2 -2,-0.8 2,-0.5 -0.783 25.4-142.9-114.8 158.2 -8.9 4.9 1.4 43 63 A Q E - F 0 55A 44 12,-2.5 12,-2.5 -2,-0.3 2,-0.3 -0.965 14.9-159.6-121.6 114.4 -9.6 5.3 -2.3 44 64 A L E - F 0 54A 1 -2,-0.5 2,-0.4 -36,-0.3 10,-0.2 -0.724 11.4-177.3 -92.3 142.3 -6.7 6.3 -4.5 45 65 A Q E - F 0 53A 8 8,-1.7 8,-2.0 -2,-0.3 2,-0.3 -0.986 24.1-130.6-143.1 127.9 -7.5 7.8 -7.9 46 66 A A E - F 0 52A 0 631,-0.5 6,-0.3 -2,-0.4 633,-0.2 -0.627 18.2-176.9 -77.7 132.2 -5.1 8.8 -10.6 47 67 A E E S- 0 0 57 4,-2.5 2,-0.3 1,-0.6 -1,-0.2 0.669 77.2 -21.6 -97.2 -25.2 -5.9 12.3 -11.8 48 68 A E E > S- F 0 51A 95 3,-1.3 3,-2.5 -3,-0.1 -1,-0.6 -0.930 106.8 -39.3-168.8 170.0 -3.1 12.0 -14.4 49 69 A R T 3 S- 0 0 114 1,-0.3 677,-0.2 -2,-0.3 3,-0.1 -0.100 126.5 -6.4 -46.1 129.3 -0.0 9.8 -14.8 50 70 A G T 3 S+ 0 0 7 626,-0.5 35,-2.8 675,-0.4 2,-0.4 0.450 113.7 104.6 65.4 -1.7 1.8 9.2 -11.6 51 71 A V E < +FG 48 84A 2 -3,-2.5 -4,-2.5 33,-0.2 -3,-1.3 -0.942 45.6 169.7-116.7 134.5 -0.5 11.7 -9.8 52 72 A V E -FG 46 83A 0 31,-2.5 31,-2.4 -2,-0.4 2,-0.3 -0.868 29.6-135.1-137.9 169.6 -3.3 10.7 -7.4 53 73 A S E -F 45 0A 2 -8,-2.0 -8,-1.7 -2,-0.3 2,-0.5 -0.873 20.2-144.8-119.0 153.3 -5.9 11.9 -4.9 54 74 A I E -F 44 0A 0 27,-0.4 9,-3.5 9,-0.4 2,-0.5 -0.940 16.1-170.0-126.4 109.5 -6.4 10.0 -1.6 55 75 A K E -FH 43 62A 50 -12,-2.5 -12,-2.5 -2,-0.5 2,-0.7 -0.876 22.2-136.4-107.1 125.7 -10.0 9.9 -0.3 56 76 A G E >> -FH 42 61A 0 5,-2.7 4,-1.5 -2,-0.5 5,-0.9 -0.683 20.4-149.5 -74.4 114.1 -10.9 8.6 3.1 57 77 A V T 45S+ 0 0 72 -16,-2.2 3,-0.3 -2,-0.7 -1,-0.2 0.949 91.0 36.1 -52.1 -58.2 -13.9 6.5 2.2 58 78 A S T 45S+ 0 0 66 -20,-0.5 -1,-0.2 -17,-0.5 -19,-0.1 0.986 119.1 47.1 -59.0 -63.2 -15.8 7.0 5.5 59 79 A A T 45S- 0 0 11 -36,-0.6 -1,-0.2 1,-0.1 -2,-0.2 0.684 96.3-146.3 -52.5 -17.4 -14.7 10.6 6.2 60 80 A N T <5 + 0 0 93 -4,-1.5 2,-0.3 -3,-0.3 -3,-0.2 0.871 58.5 121.2 47.4 39.9 -15.7 11.2 2.5 61 81 A R E < -H 56 0A 52 -5,-0.9 -5,-2.7 -38,-0.1 2,-0.4 -0.903 62.8-120.4-128.9 158.2 -12.8 13.7 2.5 62 82 A Y E -HI 55 74A 27 12,-3.2 12,-2.2 -2,-0.3 -7,-0.2 -0.840 28.1-113.3-104.2 135.8 -9.7 14.1 0.4 63 83 A L E + I 0 73A 0 -9,-3.5 -9,-0.4 -2,-0.4 2,-0.3 -0.377 45.2 175.2 -62.5 140.0 -6.2 14.1 1.9 64 84 A A E - I 0 72A 4 8,-2.4 8,-2.4 -11,-0.1 2,-0.6 -0.997 28.9-143.7-150.6 148.8 -4.6 17.5 1.4 65 85 A M E - I 0 71A 0 15,-1.9 6,-0.2 -2,-0.3 35,-0.1 -0.956 24.4-146.4-119.2 115.3 -1.4 19.3 2.4 66 86 A K > - 0 0 23 4,-2.2 3,-2.2 -2,-0.6 50,-0.1 -0.171 33.6 -89.8 -75.2 167.2 -1.8 23.0 3.2 67 87 A E T 3 S+ 0 0 65 1,-0.3 -1,-0.1 2,-0.1 -2,-0.0 0.825 125.9 51.3 -43.0 -44.4 0.7 25.9 2.5 68 88 A D T 3 S- 0 0 103 1,-0.1 49,-0.4 48,-0.0 -1,-0.3 0.643 121.5-103.5 -75.0 -12.7 2.4 25.4 5.9 69 89 A G S < S+ 0 0 0 -3,-2.2 47,-2.3 1,-0.3 -2,-0.1 0.389 74.5 141.8 105.2 -2.3 2.9 21.7 5.4 70 90 A R - 0 0 14 45,-0.2 -4,-2.2 46,-0.1 2,-0.4 -0.402 45.1-132.8 -71.8 149.1 0.0 20.6 7.7 71 91 A L E +I 65 0A 6 -6,-0.2 -42,-0.5 -42,-0.1 2,-0.3 -0.906 37.1 145.6-109.7 134.0 -2.1 17.6 6.6 72 92 A L E -I 64 0A 77 -8,-2.4 -8,-2.4 -2,-0.4 2,-0.5 -0.936 42.9-111.8-153.6 172.4 -5.9 17.6 6.7 73 93 A A E -I 63 0A 3 -46,-2.7 2,-0.3 -2,-0.3 -10,-0.2 -0.952 27.4-160.4-118.8 118.4 -8.9 16.2 4.8 74 94 A S E -I 62 0A 25 -12,-2.2 -12,-3.2 -2,-0.5 -47,-0.1 -0.720 21.6-138.1 -99.4 146.7 -11.2 18.5 2.8 75 95 A K S S+ 0 0 69 -2,-0.3 2,-0.5 -14,-0.2 -1,-0.1 0.820 93.1 54.4 -68.1 -28.9 -14.7 17.7 1.7 76 96 A S S S- 0 0 85 -14,-0.1 2,-0.2 -15,-0.0 -1,-0.1 -0.915 91.2-115.7-115.2 131.5 -14.0 19.3 -1.6 77 97 A V + 0 0 43 -2,-0.5 2,-0.2 2,-0.1 -2,-0.1 -0.378 41.7 168.9 -62.7 126.8 -11.1 18.4 -4.0 78 98 A T > - 0 0 54 -2,-0.2 3,-1.3 -4,-0.1 -4,-0.0 -0.628 53.4 -88.4-126.1-175.3 -8.7 21.3 -4.5 79 99 A D T 3 S+ 0 0 89 1,-0.3 3,-0.4 -2,-0.2 20,-0.2 0.474 122.5 65.0 -79.7 3.7 -5.2 21.5 -6.1 80 100 A E T 3 S+ 0 0 45 1,-0.2 -15,-1.9 19,-0.1 -1,-0.3 0.232 85.2 75.2-104.4 10.7 -3.7 20.6 -2.7 81 101 A C S < S+ 0 0 0 -3,-1.3 -27,-0.4 -17,-0.2 2,-0.4 0.151 77.3 93.1-106.4 16.0 -5.3 17.1 -2.8 82 102 A F + 0 0 17 -3,-0.4 16,-2.7 -29,-0.1 17,-0.5 -0.935 48.7 178.5-117.6 133.5 -2.9 15.7 -5.5 83 103 A F E -GJ 52 97A 0 -31,-2.4 -31,-2.5 -2,-0.4 2,-0.5 -0.984 33.4-116.8-134.2 141.6 0.3 13.8 -4.8 84 104 A F E -GJ 51 96A 53 12,-3.7 12,-2.0 -2,-0.4 2,-0.6 -0.656 32.7-147.8 -75.0 124.1 3.0 12.2 -7.0 85 105 A E E + J 0 95A 9 -35,-2.8 2,-0.4 -2,-0.5 10,-0.2 -0.848 21.3 179.4 -95.4 127.0 2.8 8.5 -6.2 86 106 A R E - J 0 94A 94 8,-2.0 8,-1.9 -2,-0.6 2,-0.9 -0.993 27.7-146.0-133.0 134.3 6.1 6.8 -6.5 87 107 A L E - J 0 93A 22 -2,-0.4 6,-0.2 6,-0.2 588,-0.0 -0.872 33.4-145.5 -96.5 102.4 7.1 3.2 -5.9 88 108 A E > - 0 0 42 4,-2.5 3,-2.2 -2,-0.9 4,-0.0 -0.131 25.0-102.4 -65.9 165.3 10.6 3.6 -4.5 89 109 A S T 3 S+ 0 0 71 1,-0.3 1163,-0.3 2,-0.1 -1,-0.1 0.697 123.2 61.0 -61.1 -21.7 13.5 1.2 -5.2 90 110 A N T 3 S- 0 0 52 2,-0.2 -1,-0.3 1245,-0.0 3,-0.1 0.374 119.1-111.8 -87.0 3.8 12.9 -0.2 -1.7 91 111 A N S < S+ 0 0 15 -3,-2.2 2,-0.3 1,-0.3 -2,-0.1 0.726 81.1 114.2 73.0 25.0 9.4 -1.2 -2.7 92 112 A Y - 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