==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=4-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER GROWTH FACTOR/GROWTH FACTOR RECEPTOR 23-APR-01 1IIL . COMPND 2 MOLECULE: HEPARIN-BINDING GROWTH FACTOR 2; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,D.M.ORNITZ, . 1361 10 8 6 2 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 59507.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 845 62.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 44 3.2 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 456 33.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 12 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 20 1.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 24 1.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 4 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 133 9.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 146 10.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 16 1.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 12 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 20 20 8 16 12 12 0 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 12 4 0 8 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 22 A P 0 0 75 0, 0.0 637,-0.1 0, 0.0 634,-0.0 0.000 360.0 360.0 360.0 150.1 0.7 -10.4 -8.1 2 23 A P + 0 0 116 0, 0.0 2,-0.2 0, 0.0 634,-0.1 -0.091 360.0 47.4 -47.1 124.9 -2.7 -10.4 -6.2 3 24 A G - 0 0 62 127,-0.0 2,-0.3 128,-0.0 127,-0.0 -0.686 64.3-108.9 133.3 172.7 -4.9 -7.3 -6.4 4 25 A H > - 0 0 38 -2,-0.2 3,-1.4 4,-0.1 663,-0.1 -0.969 15.9-133.4-148.2 132.7 -6.5 -4.6 -8.6 5 26 A F T 3 S+ 0 0 4 -2,-0.3 38,-0.2 663,-0.3 -1,-0.1 0.725 103.1 52.5 -54.3 -32.3 -5.8 -0.9 -9.0 6 27 A K T 3 S+ 0 0 56 690,-0.1 -1,-0.3 36,-0.1 691,-0.1 0.694 87.6 100.8 -82.9 -13.5 -9.4 0.4 -8.8 7 28 A D S < S- 0 0 63 -3,-1.4 36,-0.3 1,-0.1 34,-0.0 -0.357 84.4-104.4 -67.9 144.2 -10.1 -1.4 -5.6 8 29 A P - 0 0 29 0, 0.0 124,-0.9 0, 0.0 2,-0.3 -0.305 45.7-163.9 -65.4 157.8 -10.0 0.6 -2.4 9 30 A K E -AB 41 131A 31 32,-2.9 32,-3.2 122,-0.2 2,-0.4 -0.913 23.7-123.5-141.6 167.2 -6.9 0.2 -0.2 10 31 A R E - B 0 130A 26 120,-3.0 120,-2.9 -2,-0.3 2,-0.7 -0.861 25.9-140.7-106.2 144.8 -5.4 0.7 3.2 11 32 A L E - B 0 129A 1 28,-0.4 9,-2.7 -2,-0.4 2,-0.4 -0.917 16.6-159.0-111.2 106.1 -2.2 2.7 3.2 12 33 A Y E -CB 19 128A 0 116,-2.7 116,-2.7 -2,-0.7 2,-0.5 -0.713 5.9-145.9 -86.9 127.4 0.2 1.2 5.8 13 34 A C E >> -CB 18 127A 0 5,-3.4 4,-0.9 -2,-0.4 5,-0.6 -0.814 5.9-147.8 -95.8 126.6 3.0 3.4 7.0 14 35 A K T 45S+ 0 0 59 112,-2.7 2,-1.0 -2,-0.5 110,-0.1 0.809 81.2 87.9 -60.2 -29.8 6.3 1.7 7.8 15 36 A N T >45S- 0 0 30 108,-0.6 3,-0.7 111,-0.4 -2,-0.1 -0.601 122.0 -21.6 -75.0 103.8 6.9 4.2 10.6 16 37 A G T 345S- 0 0 10 -2,-1.0 535,-0.3 1,-0.2 -1,-0.2 0.275 102.4 -96.0 81.4 -15.4 5.2 2.6 13.6 17 38 A G T 3<5S+ 0 0 2 -4,-0.9 2,-0.3 1,-0.2 535,-0.2 0.916 70.8 157.6 71.6 42.7 3.0 0.5 11.4 18 39 A F E < < -C 13 0A 15 -3,-0.7 -5,-3.4 -5,-0.6 2,-0.4 -0.755 40.2-128.4-100.8 149.3 -0.1 2.8 11.3 19 40 A F E -CD 12 31A 4 12,-3.4 12,-1.7 -2,-0.3 -7,-0.2 -0.775 34.7-106.7 -92.6 136.6 -2.8 2.8 8.6 20 41 A L E - D 0 30A 0 -9,-2.7 2,-0.4 -2,-0.4 -9,-0.3 -0.461 41.9-160.4 -63.7 129.5 -3.5 6.2 7.2 21 42 A R E - D 0 29A 40 8,-3.3 8,-1.9 -2,-0.2 2,-0.7 -0.956 16.3-163.9-122.8 131.1 -6.9 7.3 8.6 22 43 A I E - D 0 28A 0 16,-2.7 36,-0.4 -2,-0.4 6,-0.2 -0.905 19.4-147.5-113.8 105.3 -9.2 10.0 7.2 23 44 A H > - 0 0 14 4,-3.0 3,-2.6 -2,-0.7 49,-0.1 -0.357 22.2-117.6 -70.7 147.5 -11.8 11.1 9.8 24 45 A P T 3 S+ 0 0 61 0, 0.0 -1,-0.1 0, 0.0 -2,-0.0 0.774 116.3 55.5 -54.2 -28.4 -15.4 12.2 8.8 25 46 A D T 3 S- 0 0 86 2,-0.1 -2,-0.1 35,-0.0 47,-0.0 0.303 125.9 -99.0 -90.4 9.3 -14.6 15.6 10.3 26 47 A G S < S+ 0 0 9 -3,-2.6 46,-1.8 1,-0.3 2,-0.2 0.372 76.7 138.7 92.9 -7.1 -11.5 16.1 8.2 27 48 A R - 0 0 129 44,-0.2 -4,-3.0 -5,-0.1 2,-0.5 -0.510 37.5-154.4 -74.3 141.0 -8.8 15.1 10.7 28 49 A V E +D 22 0A 7 42,-0.5 84,-0.6 -6,-0.2 2,-0.2 -0.968 33.5 123.6-121.1 125.1 -5.9 12.9 9.4 29 50 A D E -DE 21 111A 29 -8,-1.9 -8,-3.3 -2,-0.5 2,-0.3 -0.731 48.8 -95.5-151.8-159.7 -4.0 10.6 11.6 30 51 A G E -D 20 0A 6 80,-2.4 2,-0.3 -10,-0.2 -10,-0.2 -0.986 27.2-178.5-138.0 147.2 -2.9 6.9 11.9 31 52 A V E -D 19 0A 22 -12,-1.7 -12,-3.4 -2,-0.3 79,-0.1 -0.952 27.7-141.7-139.6 160.8 -4.2 3.8 13.7 32 53 A R S S+ 0 0 92 -2,-0.3 2,-0.9 -14,-0.2 -1,-0.1 0.597 70.0 106.8 -97.6 -12.0 -3.2 0.2 14.1 33 54 A E > - 0 0 106 1,-0.2 3,-1.9 -14,-0.1 -2,-0.1 -0.556 51.8-164.4 -76.1 103.1 -6.7 -1.2 14.1 34 55 A K T 3 S+ 0 0 119 -2,-0.9 -1,-0.2 1,-0.3 5,-0.1 0.696 87.8 61.1 -56.3 -22.3 -7.3 -3.0 10.7 35 56 A S T 3 S+ 0 0 88 3,-0.0 -1,-0.3 -3,-0.0 -2,-0.1 0.643 73.1 118.6 -82.1 -17.2 -11.0 -2.9 11.5 36 57 A D X - 0 0 25 -3,-1.9 3,-0.9 1,-0.1 4,-0.1 -0.264 59.6-145.4 -53.9 131.1 -11.3 0.8 11.6 37 58 A P G > S+ 0 0 81 0, 0.0 3,-0.5 0, 0.0 20,-0.5 0.612 89.8 65.4 -76.0 -12.9 -13.7 2.0 8.9 38 59 A H G 3 S+ 0 0 40 1,-0.2 -16,-2.7 19,-0.1 -2,-0.1 0.231 86.8 68.6 -97.2 16.9 -11.9 5.3 8.2 39 60 A I G < + 0 0 0 -3,-0.9 2,-0.7 -18,-0.2 -28,-0.4 0.422 70.0 105.6-108.0 -4.5 -8.7 3.7 6.8 40 61 A K < - 0 0 86 -3,-0.5 16,-1.9 -30,-0.1 17,-0.5 -0.691 55.6-178.0 -79.0 116.2 -10.4 2.4 3.7 41 62 A L E -AF 9 55A 0 -32,-3.2 -32,-2.9 -2,-0.7 2,-0.5 -0.782 27.2-141.0-119.4 161.0 -9.1 4.7 0.9 42 63 A Q E - F 0 54A 49 12,-2.1 12,-2.5 -2,-0.3 2,-0.3 -0.978 15.9-156.2-122.7 118.2 -9.7 5.1 -2.8 43 64 A L E + F 0 53A 4 -2,-0.5 2,-0.4 -36,-0.3 10,-0.2 -0.729 14.6 180.0 -91.4 141.3 -6.6 6.0 -4.9 44 65 A Q E - F 0 52A 9 8,-1.9 8,-2.2 -2,-0.3 2,-0.4 -0.959 23.0-135.1-146.6 124.1 -7.3 7.8 -8.2 45 66 A A E - F 0 51A 0 627,-0.5 6,-0.3 -2,-0.4 629,-0.2 -0.639 14.9-175.7 -79.6 133.0 -4.8 9.0 -10.8 46 67 A E E S- 0 0 56 4,-2.4 2,-0.3 1,-0.4 -1,-0.2 0.680 77.3 -18.8 -96.2 -25.8 -5.5 12.5 -12.1 47 68 A E E > S- F 0 50A 92 3,-1.2 3,-2.4 673,-0.0 -1,-0.4 -0.930 106.0 -40.5-164.8 176.3 -2.6 12.1 -14.6 48 69 A R T 3 S- 0 0 122 1,-0.3 673,-0.2 -2,-0.3 3,-0.1 -0.249 127.5 -4.2 -55.2 124.1 0.5 9.9 -15.0 49 70 A G T 3 S+ 0 0 9 622,-0.5 35,-2.7 671,-0.3 2,-0.4 0.483 112.9 105.9 73.4 2.3 2.2 9.3 -11.6 50 71 A V E < +FG 47 83A 2 -3,-2.4 -4,-2.4 33,-0.2 -3,-1.2 -0.956 43.5 172.0-121.9 130.9 -0.3 11.7 -9.8 51 72 A V E -FG 45 82A 0 31,-2.8 31,-2.7 -2,-0.4 2,-0.4 -0.858 27.4-140.0-133.0 166.6 -3.1 10.6 -7.5 52 73 A S E -F 44 0A 2 -8,-2.2 -8,-1.9 -2,-0.3 2,-0.5 -0.898 21.5-143.8-118.8 149.8 -5.7 11.9 -5.1 53 74 A I E -F 43 0A 0 27,-0.5 9,-3.7 -2,-0.4 2,-0.5 -0.960 16.3-168.4-122.5 114.6 -6.4 9.9 -2.0 54 75 A K E -FH 42 61A 47 -12,-2.5 -12,-2.1 -2,-0.5 2,-0.8 -0.885 22.6-136.2-112.2 126.0 -10.0 9.7 -0.8 55 76 A G E >> -FH 41 60A 1 5,-2.6 4,-1.9 -2,-0.5 5,-1.1 -0.661 21.3-154.8 -73.1 111.9 -11.2 8.5 2.6 56 77 A V T 45S+ 0 0 59 -16,-1.9 -1,-0.2 -2,-0.8 3,-0.1 0.956 88.9 39.3 -54.3 -58.9 -14.2 6.4 1.4 57 78 A S T 45S+ 0 0 66 -17,-0.5 -1,-0.2 -20,-0.5 -19,-0.1 0.943 120.5 44.6 -58.2 -51.5 -16.2 6.6 4.7 58 79 A A T 45S- 0 0 12 -36,-0.4 -1,-0.2 2,-0.1 -2,-0.2 0.728 96.2-145.3 -66.5 -21.8 -15.3 10.2 5.4 59 80 A N T <5 + 0 0 99 -4,-1.9 2,-0.3 1,-0.2 -3,-0.2 0.891 58.3 122.7 55.8 39.7 -16.0 11.0 1.7 60 81 A R E < -H 55 0A 65 -5,-1.1 -5,-2.6 -38,-0.1 2,-0.4 -0.944 61.6-122.0-130.5 151.9 -13.2 13.6 1.9 61 82 A Y E -HI 54 73A 33 12,-3.3 12,-1.9 -2,-0.3 -7,-0.2 -0.813 28.0-114.5-100.1 132.6 -9.9 14.0 -0.1 62 83 A L E + I 0 72A 0 -9,-3.7 -9,-0.3 -2,-0.4 2,-0.3 -0.298 44.4 173.8 -60.2 144.6 -6.5 13.9 1.6 63 84 A A E - I 0 71A 4 8,-2.5 8,-2.0 -11,-0.1 2,-0.5 -0.995 29.3-140.8-155.6 149.9 -4.8 17.3 1.2 64 85 A M E - I 0 70A 0 15,-2.1 6,-0.2 -2,-0.3 17,-0.1 -0.969 24.5-142.8-117.4 123.5 -1.7 19.1 2.4 65 86 A K > - 0 0 22 4,-2.9 3,-2.6 -2,-0.5 50,-0.1 -0.216 33.0 -92.1 -79.5 169.4 -1.9 22.7 3.4 66 87 A E T 3 S+ 0 0 67 1,-0.3 -1,-0.1 2,-0.1 -2,-0.0 0.747 126.1 50.5 -50.9 -30.6 0.6 25.6 2.8 67 88 A D T 3 S- 0 0 106 2,-0.1 49,-0.3 48,-0.0 -1,-0.3 0.272 123.4-100.6 -96.0 12.4 2.2 24.9 6.2 68 89 A G S < S+ 0 0 0 -3,-2.6 47,-2.6 1,-0.3 2,-0.2 0.542 74.8 145.1 84.2 5.6 2.6 21.2 5.7 69 90 A R - 0 0 13 45,-0.2 -4,-2.9 46,-0.1 2,-0.3 -0.528 40.9-138.0 -78.6 144.6 -0.5 20.3 7.7 70 91 A L E +I 64 0A 5 -6,-0.2 -42,-0.5 -2,-0.2 2,-0.3 -0.799 38.3 132.6-104.0 147.6 -2.5 17.3 6.6 71 92 A L E -I 63 0A 76 -8,-2.0 -8,-2.5 -2,-0.3 2,-0.4 -0.944 45.7-111.0-173.4 174.6 -6.3 17.1 6.5 72 93 A A E -I 62 0A 1 -46,-1.8 2,-0.3 -2,-0.3 -10,-0.2 -0.988 24.1-158.1-130.1 127.8 -9.1 16.0 4.2 73 94 A S E -I 61 0A 30 -12,-1.9 -12,-3.3 -2,-0.4 -47,-0.1 -0.706 24.3-130.7-104.0 154.4 -11.6 18.3 2.5 74 95 A K S S+ 0 0 71 -2,-0.3 2,-0.4 -14,-0.2 -1,-0.1 0.807 96.0 56.0 -69.7 -29.3 -15.0 17.5 1.0 75 96 A S S S- 0 0 84 -14,-0.1 2,-0.4 -15,-0.0 -2,-0.1 -0.862 89.6-116.5-111.1 141.8 -14.0 19.3 -2.2 76 97 A V + 0 0 43 -2,-0.4 2,-0.2 2,-0.1 -13,-0.1 -0.574 40.8 165.7 -76.1 125.6 -11.0 18.5 -4.4 77 98 A T > - 0 0 61 -2,-0.4 3,-1.9 -4,-0.1 -4,-0.0 -0.728 54.9 -88.1-128.4 179.6 -8.5 21.3 -4.7 78 99 A D T 3 S+ 0 0 107 1,-0.3 3,-0.5 -2,-0.2 20,-0.2 0.542 122.2 66.7 -69.9 -2.9 -4.9 21.5 -6.0 79 100 A E T 3 S+ 0 0 54 1,-0.2 -15,-2.1 19,-0.1 -1,-0.3 0.328 87.0 71.6 -96.8 8.0 -3.7 20.6 -2.6 80 101 A C S < S+ 0 0 0 -3,-1.9 -27,-0.5 -17,-0.2 2,-0.4 0.244 79.1 94.2-104.8 10.7 -5.2 17.1 -3.0 81 102 A F - 0 0 13 -3,-0.5 16,-2.7 -29,-0.1 17,-0.5 -0.885 47.8-180.0-113.4 136.0 -2.7 15.8 -5.6 82 103 A F E -GJ 51 96A 0 -31,-2.7 -31,-2.8 -2,-0.4 2,-0.5 -0.989 31.4-121.9-137.2 139.5 0.4 13.7 -5.0 83 104 A F E -GJ 50 95A 36 12,-3.3 12,-2.1 -2,-0.4 2,-0.6 -0.645 32.0-147.5 -73.8 123.7 3.2 12.2 -7.1 84 105 A E E - J 0 94A 10 -35,-2.7 2,-0.4 -2,-0.5 10,-0.2 -0.862 19.9-176.0 -96.0 127.3 3.1 8.5 -6.2 85 106 A R E - J 0 93A 99 8,-2.3 8,-2.0 -2,-0.6 2,-0.8 -0.980 24.3-145.2-128.7 138.3 6.5 6.9 -6.4 86 107 A L E - J 0 92A 10 -2,-0.4 6,-0.2 6,-0.2 -2,-0.0 -0.880 29.5-150.3 -99.6 103.6 7.6 3.3 -6.0 87 108 A E > - 0 0 39 4,-2.2 3,-1.7 -2,-0.8 39,-0.0 -0.162 26.6-103.1 -70.6 169.2 11.0 3.5 -4.3 88 109 A S T 3 S+ 0 0 57 1,-0.3 1173,-0.3 2,-0.1 -1,-0.1 0.795 121.6 60.7 -63.7 -29.8 13.8 0.9 -4.7 89 110 A N T 3 S- 0 0 43 2,-0.1 -1,-0.3 1,-0.0 3,-0.1 0.439 118.9-113.7 -77.4 1.0 12.9 -0.6 -1.3 90 111 A N S < S+ 0 0 2 -3,-1.7 2,-0.3 1,-0.3 -2,-0.1 0.687 78.4 117.0 72.7 23.9 9.5 -1.3 -2.7 91 112 A Y - 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