==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER SIGNALING PROTEIN 11-MAY-01 1IMV . COMPND 2 MOLECULE: PIGMENT EPITHELIUM-DERIVED FACTOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR M.SIMONOVIC,P.G.W.GETTINS,K.VOLZ . 375 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 17130.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 264 70.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 23 6.1 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 73 19.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 32 8.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 30 8.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 91 24.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 5 1.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 3 1 0 0 0 0 2 2 1 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 2 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 0 1 0 1 3 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 16 A T 0 0 164 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 -58.7 28.3 12.7 1.4 2 17 A G + 0 0 59 1,-0.4 2,-0.1 75,-0.0 0, 0.0 0.353 360.0 121.3 115.9 -6.0 31.6 14.4 0.9 3 18 A A - 0 0 72 1,-0.1 2,-0.6 74,-0.0 -1,-0.4 -0.474 69.0 -98.4 -89.9 161.1 32.4 13.7 -2.8 4 19 A L + 0 0 117 -2,-0.1 2,-0.3 74,-0.0 -1,-0.1 -0.690 58.6 144.8 -83.6 117.6 32.9 16.2 -5.6 5 20 A V - 0 0 110 -2,-0.6 2,-0.3 72,-0.2 74,-0.2 -0.858 50.8 -81.1-141.5 173.9 29.8 16.8 -7.7 6 21 A E - 0 0 141 -2,-0.3 7,-0.1 1,-0.1 2,-0.0 -0.603 51.1-103.8 -84.2 142.8 28.0 19.6 -9.6 7 22 A E + 0 0 48 -2,-0.3 -1,-0.1 1,-0.1 6,-0.0 -0.276 33.3 179.2 -65.1 146.8 25.9 22.1 -7.7 8 23 A E + 0 0 149 1,-0.1 -1,-0.1 -2,-0.0 5,-0.1 0.771 60.3 79.1-114.2 -57.6 22.1 21.9 -7.8 9 24 A D S >> S- 0 0 46 1,-0.2 3,-1.1 3,-0.1 4,-0.9 -0.424 80.5-137.5 -57.4 119.4 20.5 24.7 -5.7 10 25 A P H 3> S+ 0 0 94 0, 0.0 4,-0.6 0, 0.0 -1,-0.2 0.708 98.1 67.7 -53.4 -21.7 21.0 27.5 -8.2 11 26 A F H 34 S+ 0 0 49 1,-0.2 3,-0.5 2,-0.2 6,-0.2 0.905 105.2 37.6 -68.2 -42.7 22.1 29.7 -5.3 12 27 A F H <4 S+ 0 0 13 -3,-1.1 -1,-0.2 1,-0.2 6,-0.1 0.535 98.4 78.6 -88.0 -6.3 25.3 27.8 -4.7 13 28 A K H < S+ 0 0 134 -4,-0.9 -1,-0.2 -5,-0.1 -2,-0.2 0.780 75.3 90.8 -71.9 -22.9 26.0 27.2 -8.4 14 29 A V S X S- 0 0 61 -4,-0.6 4,-2.4 -3,-0.5 3,-0.4 -0.578 82.5-134.4 -71.8 125.4 27.2 30.8 -8.5 15 30 A P H > S+ 0 0 74 0, 0.0 4,-2.4 0, 0.0 5,-0.2 0.896 101.2 47.6 -48.8 -52.9 31.0 30.9 -7.8 16 31 A V H > S+ 0 0 10 1,-0.2 4,-1.8 2,-0.2 5,-0.1 0.862 114.8 47.1 -59.5 -36.7 31.0 33.8 -5.3 17 32 A N H > S+ 0 0 12 -3,-0.4 4,-1.9 2,-0.2 -1,-0.2 0.865 110.0 53.8 -71.1 -36.8 28.1 32.3 -3.4 18 33 A K H X S+ 0 0 45 -4,-2.4 4,-1.4 2,-0.2 -2,-0.2 0.891 110.2 46.7 -62.6 -43.3 29.8 28.9 -3.4 19 34 A L H X S+ 0 0 2 -4,-2.4 4,-2.3 -5,-0.2 5,-0.3 0.883 109.8 54.2 -68.0 -38.0 32.9 30.4 -1.9 20 35 A A H X S+ 0 0 1 -4,-1.8 4,-2.3 -5,-0.2 344,-0.4 0.852 104.5 55.0 -65.2 -33.7 30.8 32.3 0.7 21 36 A A H X S+ 0 0 7 -4,-1.9 4,-2.0 2,-0.2 239,-0.3 0.884 110.1 46.5 -66.7 -37.3 29.2 29.0 1.8 22 37 A A H X S+ 0 0 6 -4,-1.4 4,-1.6 2,-0.2 -2,-0.2 0.984 115.3 43.2 -66.9 -60.2 32.6 27.5 2.4 23 38 A V H X S+ 0 0 3 -4,-2.3 4,-1.7 1,-0.2 -2,-0.2 0.883 115.6 51.3 -53.6 -40.7 34.1 30.4 4.3 24 39 A S H X S+ 0 0 5 -4,-2.3 4,-2.2 -5,-0.3 -1,-0.2 0.890 105.4 54.2 -66.8 -38.2 30.8 30.7 6.2 25 40 A N H X S+ 0 0 15 -4,-2.0 4,-1.7 1,-0.2 -1,-0.2 0.770 106.3 53.6 -65.5 -26.2 30.8 27.0 7.1 26 41 A F H X S+ 0 0 0 -4,-1.6 4,-2.3 47,-0.2 -1,-0.2 0.888 105.9 54.1 -71.6 -40.2 34.2 27.7 8.6 27 42 A G H X S+ 0 0 0 -4,-1.7 4,-2.7 1,-0.2 -2,-0.2 0.926 107.1 49.6 -57.9 -46.4 32.6 30.4 10.6 28 43 A Y H X S+ 0 0 2 -4,-2.2 4,-2.7 2,-0.2 -1,-0.2 0.889 108.7 52.3 -62.0 -40.5 30.0 28.1 12.0 29 44 A D H X S+ 0 0 37 -4,-1.7 4,-2.3 2,-0.2 -1,-0.2 0.943 110.9 48.0 -60.7 -46.1 32.6 25.5 13.0 30 45 A L H X S+ 0 0 0 -4,-2.3 4,-3.0 1,-0.2 5,-0.2 0.930 110.9 50.7 -59.8 -47.1 34.5 28.3 14.8 31 46 A Y H X S+ 0 0 0 -4,-2.7 4,-3.5 1,-0.2 5,-0.3 0.934 110.1 49.8 -56.4 -48.1 31.3 29.4 16.5 32 47 A R H X S+ 0 0 41 -4,-2.7 4,-1.4 2,-0.2 -1,-0.2 0.884 112.9 46.8 -59.8 -39.7 30.5 25.9 17.7 33 48 A V H X S+ 0 0 29 -4,-2.3 4,-0.8 -5,-0.2 -1,-0.2 0.929 117.3 43.2 -68.0 -43.7 34.0 25.4 19.0 34 49 A R H X S+ 0 0 45 -4,-3.0 4,-1.9 2,-0.2 3,-0.4 0.857 109.8 54.5 -71.0 -37.6 33.9 28.8 20.8 35 50 A S H < S+ 0 0 4 -4,-3.5 -1,-0.2 1,-0.2 -2,-0.2 0.877 106.1 55.2 -63.0 -35.8 30.4 28.5 22.1 36 51 A S H < S+ 0 0 96 -4,-1.4 -1,-0.2 -5,-0.3 -2,-0.2 0.781 109.7 46.3 -66.6 -28.0 31.5 25.2 23.7 37 52 A M H < S+ 0 0 72 -4,-0.8 -2,-0.2 -3,-0.4 -1,-0.2 0.778 114.0 48.1 -85.4 -28.2 34.3 27.1 25.4 38 53 A S >< + 0 0 25 -4,-1.9 3,-0.5 1,-0.1 -1,-0.2 -0.672 64.9 159.1-113.7 75.5 32.1 29.9 26.6 39 54 A P T 3 S+ 0 0 78 0, 0.0 -1,-0.1 0, 0.0 -2,-0.1 0.683 78.9 30.2 -69.2 -20.5 29.1 28.0 28.2 40 55 A T T 3 S+ 0 0 101 -3,-0.1 2,-0.3 2,-0.1 -2,-0.1 0.249 109.4 70.9-125.7 13.2 28.0 31.0 30.3 41 56 A T S < S- 0 0 69 -3,-0.5 -3,-0.1 -6,-0.2 328,-0.1 -0.923 85.2 -94.7-130.8 155.3 29.0 34.1 28.4 42 57 A N - 0 0 21 -2,-0.3 2,-0.5 330,-0.1 328,-0.2 -0.276 34.1-145.1 -62.3 152.5 27.8 35.8 25.2 43 58 A V E -A 369 0A 6 326,-1.6 326,-1.6 2,-0.0 2,-0.5 -0.958 16.5-177.1-124.6 112.5 29.7 34.9 22.1 44 59 A L E +A 368 0A 9 -2,-0.5 2,-0.3 324,-0.2 324,-0.2 -0.945 15.1 167.0-109.4 128.5 30.1 37.6 19.5 45 60 A L E -A 367 0A 0 322,-2.5 322,-2.9 -2,-0.5 3,-0.1 -0.997 32.5-175.5-147.4 138.9 31.9 36.5 16.3 46 61 A S >> - 0 0 0 -2,-0.3 3,-1.5 320,-0.2 4,-0.5 -0.612 16.7-179.9-130.9 69.3 32.5 37.8 12.8 47 62 A P H >> + 0 0 2 0, 0.0 4,-3.0 0, 0.0 3,-0.9 0.687 66.7 77.0 -39.0 -39.0 34.4 34.8 11.3 48 63 A L H 3> S+ 0 0 5 316,-0.4 4,-2.5 1,-0.3 5,-0.2 0.876 92.0 51.5 -47.5 -47.7 34.9 36.4 7.9 49 64 A S H <> S+ 0 0 0 -3,-1.5 4,-1.0 1,-0.2 -1,-0.3 0.836 115.7 42.8 -61.1 -32.6 37.8 38.6 9.1 50 65 A V H < S+ 0 0 3 -4,-2.1 3,-2.0 -5,-0.2 4,-0.4 0.969 110.3 48.9 -65.5 -52.1 45.5 35.1 2.6 57 72 A L H >< S+ 0 0 0 -4,-2.2 3,-1.8 1,-0.3 -2,-0.2 0.878 96.2 71.6 -54.3 -41.7 48.3 33.4 4.5 58 73 A S G >< S+ 0 0 0 -4,-2.2 3,-0.7 1,-0.3 -1,-0.3 0.536 83.7 74.3 -56.0 -4.2 47.7 30.1 2.5 59 74 A L G < S+ 0 0 35 -3,-2.0 -1,-0.3 1,-0.2 -2,-0.2 0.902 97.5 42.9 -76.1 -42.0 49.2 32.0 -0.5 60 75 A G G < S+ 0 0 1 -3,-1.8 250,-0.7 -4,-0.4 251,-0.6 -0.101 100.6 102.0 -95.0 37.3 52.8 31.7 0.9 61 76 A A < - 0 0 0 -3,-0.7 2,-0.3 249,-0.2 247,-0.2 -0.840 66.2-124.5-119.1 156.9 52.3 28.1 1.9 62 77 A D >> - 0 0 58 245,-1.9 4,-2.8 -2,-0.3 3,-1.2 -0.692 40.7 -82.8-102.9 155.9 53.4 24.9 0.3 63 78 A E H 3> S+ 0 0 133 -2,-0.3 4,-2.7 1,-0.3 5,-0.2 0.639 124.0 40.3 -10.7 -81.4 51.3 21.8 -0.7 64 79 A R H 3> S+ 0 0 78 1,-0.2 4,-1.6 2,-0.2 -1,-0.3 0.861 123.4 40.1 -48.8 -47.0 51.0 20.0 2.6 65 80 A T H <> S+ 0 0 6 -3,-1.2 4,-2.0 2,-0.2 -1,-0.2 0.917 113.1 54.5 -71.2 -44.5 50.4 23.2 4.7 66 81 A E H X S+ 0 0 45 -4,-2.8 4,-3.4 1,-0.2 -2,-0.2 0.917 107.9 50.5 -53.5 -48.5 48.2 24.8 2.1 67 82 A S H X S+ 0 0 64 -4,-2.7 4,-2.9 -5,-0.3 5,-0.3 0.921 103.9 57.5 -57.2 -49.5 45.9 21.8 2.0 68 83 A I H X S+ 0 0 58 -4,-1.6 4,-1.0 -5,-0.2 -1,-0.2 0.927 114.6 39.9 -47.4 -48.3 45.6 21.8 5.8 69 84 A I H >X S+ 0 0 1 -4,-2.0 4,-1.1 1,-0.2 3,-1.1 0.964 113.0 52.7 -67.6 -53.1 44.3 25.3 5.5 70 85 A H H 3<>S+ 0 0 39 -4,-3.4 5,-2.3 1,-0.3 6,-0.7 0.814 106.9 54.8 -53.5 -32.6 42.2 24.8 2.4 71 86 A R H ><5S+ 0 0 135 -4,-2.9 3,-0.6 1,-0.2 -1,-0.3 0.803 104.8 51.4 -73.8 -28.9 40.4 21.9 4.0 72 87 A A H <<5S+ 0 0 13 -3,-1.1 -1,-0.2 -4,-1.0 -2,-0.2 0.661 111.0 50.1 -79.9 -16.1 39.3 23.9 7.1 73 88 A L T 3<5S- 0 0 0 -4,-1.1 -1,-0.2 -3,-0.2 -47,-0.2 0.369 112.6-119.9-100.9 2.7 37.9 26.5 4.7 74 89 A Y T X 5S+ 0 0 68 -3,-0.6 3,-1.1 -5,-0.2 -3,-0.2 0.667 73.3 132.6 66.0 20.3 35.9 23.9 2.7 75 90 A Y G > < + 0 0 12 -5,-2.3 3,-2.3 1,-0.3 -4,-0.2 0.803 57.6 71.7 -69.6 -30.2 37.8 24.8 -0.4 76 91 A D G 3 S+ 0 0 77 -6,-0.7 -1,-0.3 1,-0.3 -5,-0.1 0.474 94.8 56.0 -66.9 2.0 38.5 21.2 -1.2 77 92 A L G < S+ 0 0 72 -3,-1.1 2,-0.6 -73,-0.1 -1,-0.3 0.142 89.0 87.8-116.9 15.5 34.8 20.9 -2.1 78 93 A I < - 0 0 25 -3,-2.3 2,-1.6 2,-0.1 5,-0.1 -0.950 61.0-161.2-118.0 108.6 34.9 23.7 -4.6 79 94 A S + 0 0 81 -2,-0.6 -3,-0.1 -74,-0.2 -4,-0.0 -0.398 58.9 99.6 -87.5 62.1 35.8 22.5 -8.1 80 95 A S - 0 0 58 -2,-1.6 3,-0.1 -65,-0.0 -2,-0.1 -0.988 60.4-138.7-150.7 136.8 36.8 25.9 -9.4 81 96 A P S S+ 0 0 108 0, 0.0 5,-0.2 0, 0.0 -1,-0.0 0.167 79.9 52.4 -75.2-162.1 40.1 27.8 -9.9 82 97 A D > + 0 0 118 1,-0.2 4,-1.9 3,-0.1 5,-0.1 0.854 60.7 163.0 31.4 54.8 41.0 31.4 -9.1 83 98 A I H > S+ 0 0 21 1,-0.2 4,-1.4 2,-0.2 -1,-0.2 0.805 76.9 47.3 -68.2 -26.9 39.7 30.8 -5.6 84 99 A H H > S+ 0 0 28 2,-0.2 4,-1.4 1,-0.2 -1,-0.2 0.745 106.0 57.0 -83.9 -26.7 41.5 34.0 -4.6 85 100 A G H > S+ 0 0 22 2,-0.2 4,-1.2 1,-0.2 -2,-0.2 0.892 109.8 46.1 -69.8 -38.4 40.2 35.9 -7.6 86 101 A T H X S+ 0 0 19 -4,-1.9 4,-2.7 1,-0.2 -2,-0.2 0.890 106.2 58.6 -68.8 -42.0 36.7 35.1 -6.4 87 102 A Y H X S+ 0 0 0 -4,-1.4 4,-2.4 1,-0.2 5,-0.2 0.857 100.5 57.2 -56.9 -36.7 37.6 36.1 -2.8 88 103 A K H X S+ 0 0 89 -4,-1.4 4,-2.2 2,-0.2 -1,-0.2 0.944 110.2 45.5 -58.9 -46.7 38.5 39.5 -4.0 89 104 A E H X S+ 0 0 101 -4,-1.2 4,-2.4 2,-0.2 -2,-0.2 0.971 108.7 53.3 -60.0 -59.7 35.0 39.8 -5.4 90 105 A L H X S+ 0 0 1 -4,-2.7 4,-2.3 1,-0.3 5,-0.2 0.885 111.7 47.5 -43.2 -50.1 33.2 38.4 -2.3 91 106 A L H X S+ 0 0 25 -4,-2.4 4,-1.9 1,-0.2 -1,-0.3 0.929 108.0 53.9 -60.5 -47.2 35.0 41.0 -0.2 92 107 A D H < S+ 0 0 92 -4,-2.2 4,-0.5 -5,-0.2 -1,-0.2 0.885 112.1 48.1 -54.2 -39.0 34.1 43.8 -2.6 93 108 A T H >< S+ 0 0 44 -4,-2.4 3,-0.5 1,-0.2 -2,-0.2 0.941 115.0 38.0 -69.2 -53.0 30.5 42.8 -2.3 94 109 A V H 3< S+ 0 0 0 -4,-2.3 7,-0.4 1,-0.2 -1,-0.2 0.646 115.9 51.3 -79.4 -14.3 30.0 42.5 1.5 95 110 A T T 3< S+ 0 0 51 -4,-1.9 -1,-0.2 -5,-0.2 -2,-0.2 0.519 79.9 126.6 -99.0 -3.5 32.1 45.5 2.5 96 111 A A S X S- 0 0 24 -3,-0.5 3,-1.5 -4,-0.5 5,-0.3 -0.112 74.9-109.6 -51.0 148.6 30.4 47.9 0.1 97 112 A P T 3 S+ 0 0 123 0, 0.0 -1,-0.1 0, 0.0 -3,-0.0 0.815 114.3 66.5 -50.6 -40.2 29.1 51.1 1.7 98 113 A Q T 3 S+ 0 0 106 2,-0.1 -2,-0.1 137,-0.0 138,-0.1 0.834 98.1 60.4 -54.5 -35.0 25.4 50.1 1.3 99 114 A K S < S- 0 0 1 -3,-1.5 136,-0.1 -6,-0.2 -4,-0.1 -0.106 87.1-137.8 -74.8-172.2 26.1 47.3 3.8 100 115 A N + 0 0 58 -6,-0.2 79,-0.9 135,-0.1 2,-0.4 0.176 62.0 118.4-135.7 18.3 27.2 48.6 7.2 101 116 A L E -K 178 0B 3 -7,-0.4 2,-0.5 -5,-0.3 77,-0.2 -0.700 41.7-169.1 -92.6 132.5 29.9 46.0 7.8 102 117 A K E +K 177 0B 70 75,-2.4 75,-2.6 -2,-0.4 2,-0.4 -0.986 15.8 171.1-121.5 117.7 33.6 46.9 8.2 103 118 A S E +K 176 0B 25 -2,-0.5 2,-0.3 73,-0.3 73,-0.3 -0.996 3.6 173.5-132.5 130.9 35.9 43.9 8.1 104 119 A A E -K 175 0B 11 71,-3.6 71,-2.7 -2,-0.4 2,-0.3 -0.989 11.2-165.0-139.3 147.7 39.7 43.8 7.9 105 120 A S E -K 174 0B 17 -2,-0.3 2,-0.3 69,-0.2 69,-0.2 -0.970 7.2-173.4-130.1 145.7 42.4 41.2 8.1 106 121 A R E -K 173 0B 16 67,-2.2 67,-2.5 -2,-0.3 2,-0.6 -0.996 17.1-148.7-144.9 135.4 46.1 41.6 8.7 107 122 A I E -K 172 0B 4 -2,-0.3 25,-1.9 65,-0.2 2,-0.5 -0.906 21.6-165.9-101.2 122.9 49.1 39.2 8.7 108 123 A V E -Kl 171 132B 0 63,-4.1 63,-4.0 -2,-0.6 2,-0.3 -0.952 1.7-159.8-117.3 128.7 51.8 40.2 11.1 109 124 A F E -Kl 170 133B 0 23,-2.7 25,-2.9 -2,-0.5 61,-0.2 -0.702 24.8 -93.7-107.7 157.3 55.4 38.9 11.1 110 125 A E > - 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