==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=2-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER SIGNALING PROTEIN 18-SEP-08 2K8P . COMPND 2 MOLECULE: SCLEROSTIN; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR V.VEVERKA,A.J.HENRY,P.M.SLOCOMBE,A.VENTOM,B.MULLOY, . 189 1 4 4 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 22891.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 49 25.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 22 11.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 21 11.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 2 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A G 0 0 134 0, 0.0 2,-0.3 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 157.6 -68.7 48.4 122.7 2 2 A W - 0 0 203 2,-0.0 2,-0.4 0, 0.0 0, 0.0 -0.915 360.0-146.7-134.9 161.2 -67.6 45.9 120.2 3 3 A Q + 0 0 173 -2,-0.3 2,-0.2 2,-0.0 0, 0.0 -0.953 23.3 168.3-134.9 115.1 -67.0 45.7 116.4 4 4 A A - 0 0 65 -2,-0.4 2,-0.2 2,-0.0 -2,-0.0 -0.482 17.5-140.7-113.0-175.2 -67.7 42.6 114.3 5 5 A F - 0 0 190 -2,-0.2 2,-0.3 2,-0.0 -1,-0.0 -0.822 2.0-141.1-139.5 178.0 -67.9 41.7 110.6 6 6 A K + 0 0 207 -2,-0.2 2,-0.2 2,-0.0 -2,-0.0 -0.950 23.4 161.8-150.8 126.1 -69.9 39.6 108.2 7 7 A N - 0 0 145 -2,-0.3 2,-0.2 0, 0.0 -2,-0.0 -0.648 18.0-145.3-130.0-173.2 -68.8 37.7 105.1 8 8 A D - 0 0 140 1,-0.3 -2,-0.0 -2,-0.2 0, 0.0 -0.701 32.3 -69.1-140.9-168.0 -70.0 34.9 102.8 9 9 A A - 0 0 97 -2,-0.2 -1,-0.3 1,-0.0 2,-0.2 0.162 39.8-136.4 -74.2-162.7 -68.7 31.9 100.8 10 10 A T - 0 0 122 2,-0.0 2,-0.4 0, 0.0 -1,-0.0 -0.778 11.4-165.7-166.5 116.6 -66.6 32.0 97.6 11 11 A E - 0 0 166 -2,-0.2 2,-0.7 2,-0.0 -2,-0.0 -0.892 8.6-153.8-109.8 135.4 -66.9 30.1 94.3 12 12 A I + 0 0 143 -2,-0.4 -2,-0.0 1,-0.1 0, 0.0 -0.853 32.8 147.0-110.9 97.8 -64.2 30.0 91.7 13 13 A I - 0 0 134 -2,-0.7 -1,-0.1 0, 0.0 -2,-0.0 -0.592 22.4-179.0-130.8 71.5 -65.6 29.3 88.2 14 14 A P - 0 0 88 0, 0.0 -2,-0.0 0, 0.0 0, 0.0 -0.310 23.2-151.7 -69.8 152.9 -63.4 31.2 85.7 15 15 A E + 0 0 191 2,-0.0 0, 0.0 -2,-0.0 0, 0.0 0.750 30.1 179.4 -95.1 -30.4 -64.2 31.1 82.0 16 16 A L - 0 0 127 1,-0.1 -1,-0.0 2,-0.0 0, 0.0 0.102 18.7-149.2 52.9-174.2 -60.6 31.5 80.8 17 17 A G + 0 0 47 1,-0.0 2,-0.5 0, 0.0 -1,-0.1 0.085 37.5 140.9 171.1 61.0 -59.9 31.6 77.0 18 18 A E + 0 0 168 1,-0.1 -2,-0.0 2,-0.1 -1,-0.0 -0.689 17.2 139.0-116.9 77.2 -56.5 30.2 76.0 19 19 A Y - 0 0 183 -2,-0.5 2,-0.7 2,-0.0 -1,-0.1 -0.583 27.2-176.4-119.5 68.2 -57.1 28.3 72.7 20 20 A P + 0 0 110 0, 0.0 -2,-0.1 0, 0.0 0, 0.0 -0.537 13.8 159.9 -69.7 109.3 -54.1 29.3 70.5 21 21 A E + 0 0 181 -2,-0.7 -2,-0.0 0, 0.0 0, 0.0 -0.591 14.0 177.5-133.6 72.0 -54.7 27.6 67.1 22 22 A P - 0 0 109 0, 0.0 0, 0.0 0, 0.0 0, 0.0 -0.146 35.6 -85.2 -69.7 167.7 -52.5 29.5 64.5 23 23 A P - 0 0 111 0, 0.0 0, 0.0 0, 0.0 0, 0.0 -0.145 50.9 -89.2 -69.7 167.8 -52.2 28.5 60.8 24 24 A P - 0 0 112 0, 0.0 2,-0.1 0, 0.0 0, 0.0 -0.039 30.2-157.0 -69.8 177.3 -49.8 25.9 59.4 25 25 A E + 0 0 177 2,-0.0 2,-0.2 0, 0.0 0, 0.0 -0.574 38.1 110.7-163.4 91.4 -46.3 26.5 58.2 26 26 A L - 0 0 154 -2,-0.1 2,-0.3 2,-0.0 0, 0.0 -0.675 43.5-131.5-143.2-163.0 -44.6 24.2 55.7 27 27 A E - 0 0 172 -2,-0.2 2,-0.3 2,-0.0 -2,-0.0 -0.984 10.6-172.9-161.2 152.2 -43.3 24.0 52.1 28 28 A N + 0 0 141 -2,-0.3 2,-0.3 2,-0.0 -2,-0.0 -0.836 11.2 174.7-155.4 111.9 -43.5 21.7 49.1 29 29 A N - 0 0 122 -2,-0.3 2,-0.2 2,-0.0 -2,-0.0 -0.790 12.8-150.5-116.8 160.6 -41.5 22.1 45.8 30 30 A K - 0 0 182 -2,-0.3 2,-0.3 2,-0.0 -2,-0.0 -0.659 2.7-147.8-121.3 177.9 -41.2 20.0 42.7 31 31 A T + 0 0 120 -2,-0.2 2,-0.3 2,-0.0 -2,-0.0 -0.983 22.4 151.8-152.4 137.8 -38.6 19.3 40.0 32 32 A M + 0 0 190 -2,-0.3 2,-0.3 2,-0.0 -2,-0.0 -0.875 12.2 132.4-168.1 132.0 -38.7 18.4 36.3 33 33 A N - 0 0 150 -2,-0.3 2,-0.3 2,-0.0 -2,-0.0 -0.927 28.6-139.8-163.4-175.6 -36.4 18.9 33.4 34 34 A R - 0 0 201 -2,-0.3 2,-0.3 2,-0.0 -2,-0.0 -0.989 9.7-168.6-157.7 157.7 -34.7 17.3 30.3 35 35 A A - 0 0 93 -2,-0.3 2,-0.3 0, 0.0 -2,-0.0 -0.855 12.4-133.9-141.8 176.1 -31.4 17.3 28.4 36 36 A E - 0 0 159 -2,-0.3 2,-0.2 2,-0.0 -2,-0.0 -0.968 11.0-151.6-137.3 152.4 -29.9 16.0 25.2 37 37 A N - 0 0 162 -2,-0.3 2,-0.3 2,-0.0 0, 0.0 -0.601 5.6-157.1-115.1 177.2 -26.7 14.2 24.2 38 38 A G + 0 0 78 -2,-0.2 2,-0.1 0, 0.0 -2,-0.0 -0.939 23.2 144.6-160.6 134.8 -24.5 14.1 21.1 39 39 A G + 0 0 64 -2,-0.3 -2,-0.0 2,-0.0 0, 0.0 -0.512 6.0 148.9-174.7 99.7 -21.9 11.7 19.6 40 40 A R + 0 0 246 -2,-0.1 -1,-0.0 0, 0.0 0, 0.0 -0.566 23.5 177.2-137.2 71.2 -21.3 11.0 15.9 41 41 A P - 0 0 108 0, 0.0 -2,-0.0 0, 0.0 2,-0.0 -0.146 38.0 -81.9 -69.7 167.7 -17.7 10.2 15.3 42 42 A P - 0 0 120 0, 0.0 2,-0.3 0, 0.0 0, 0.0 -0.274 39.6-161.4 -69.8 156.6 -16.1 9.2 12.0 43 43 A H + 0 0 180 -2,-0.0 0, 0.0 2,-0.0 0, 0.0 -0.933 16.6 160.3-146.7 118.9 -16.3 5.6 10.6 44 44 A H - 0 0 144 -2,-0.3 0, 0.0 1,-0.0 0, 0.0 -0.947 37.3-100.8-137.3 157.3 -14.1 4.0 7.9 45 45 A P - 0 0 112 0, 0.0 2,-0.3 0, 0.0 -1,-0.0 -0.128 39.6-105.8 -69.7 169.9 -13.2 0.5 6.8 46 46 A F + 0 0 189 2,-0.0 2,-0.3 0, 0.0 0, 0.0 -0.693 36.9 178.1-100.4 153.5 -9.9 -1.3 7.6 47 47 A E - 0 0 177 -2,-0.3 2,-0.2 2,-0.0 0, 0.0 -0.874 10.7-171.5-143.9 175.4 -7.0 -1.9 5.2 48 48 A T - 0 0 116 -2,-0.3 2,-0.4 2,-0.0 -2,-0.0 -0.822 16.3-138.2-174.5 132.1 -3.5 -3.3 5.1 49 49 A K - 0 0 201 -2,-0.2 2,-0.4 2,-0.0 -2,-0.0 -0.797 19.4-171.0 -99.4 137.4 -0.6 -3.5 2.7 50 50 A D + 0 0 132 -2,-0.4 2,-0.3 2,-0.0 -2,-0.0 -0.992 8.5 169.4-131.1 134.5 1.4 -6.6 2.1 51 51 A V + 0 0 79 -2,-0.4 -2,-0.0 2,-0.0 0, 0.0 -0.996 13.9 149.7-146.3 137.7 4.6 -7.1 0.1 52 52 A S + 0 0 120 -2,-0.3 -1,-0.0 2,-0.0 -2,-0.0 -0.280 20.6 161.2-165.9 67.1 7.1 -10.0 -0.2 53 53 A E - 0 0 160 1,-0.2 4,-0.1 2,-0.0 2,-0.1 -0.061 43.4 -81.7 -80.8-173.4 8.9 -10.1 -3.6 54 54 A Y S S+ 0 0 208 2,-0.1 -1,-0.2 29,-0.1 31,-0.1 -0.440 88.3 13.5 -89.4 165.4 12.1 -12.0 -4.5 55 55 A S S S- 0 0 59 -2,-0.1 2,-0.6 29,-0.1 29,-0.5 -0.039 115.6 -27.1 63.2-172.1 15.6 -10.8 -3.9 56 56 A a S S- 0 0 3 27,-0.2 27,-0.3 55,-0.1 -2,-0.1 -0.642 71.5-130.3 -78.7 118.6 16.4 -7.8 -1.7 57 57 A R - 0 0 136 -2,-0.6 25,-1.6 25,-0.2 2,-0.6 -0.172 18.5-115.6 -63.6 160.3 13.5 -5.4 -1.5 58 58 A E E -A 81 0A 91 23,-0.2 2,-0.8 21,-0.0 23,-0.2 -0.893 19.8-150.7-105.8 115.9 14.1 -1.7 -2.1 59 59 A L E -A 80 0A 61 21,-2.2 21,-2.7 -2,-0.6 2,-0.7 -0.751 11.0-161.6 -88.4 108.7 13.3 0.6 0.9 60 60 A H E +A 79 0A 120 -2,-0.8 2,-0.3 19,-0.2 19,-0.2 -0.813 13.7 179.4 -94.7 115.8 12.2 4.0 -0.4 61 61 A F E -A 78 0A 108 17,-2.9 17,-3.0 -2,-0.7 2,-0.4 -0.832 13.9-152.5-115.8 154.2 12.5 6.8 2.2 62 62 A T E +A 77 0A 97 -2,-0.3 2,-0.3 15,-0.2 15,-0.2 -0.988 22.4 153.9-129.9 135.1 11.7 10.5 2.1 63 63 A R E -A 76 0A 198 13,-1.5 13,-2.7 -2,-0.4 2,-0.5 -0.991 41.8-107.4-155.6 155.5 13.3 13.3 4.1 64 64 A Y - 0 0 141 -2,-0.3 2,-0.3 11,-0.2 -2,-0.0 -0.763 32.6-150.6 -91.1 124.7 13.9 17.1 3.8 65 65 A V - 0 0 29 -2,-0.5 7,-2.1 9,-0.4 2,-0.3 -0.680 14.2-176.5 -94.9 147.9 17.5 18.1 3.2 66 66 A T + 0 0 85 -2,-0.3 2,-0.4 5,-0.2 5,-0.2 -0.987 11.1 177.6-147.3 133.7 19.0 21.4 4.5 67 67 A D - 0 0 88 3,-0.4 3,-0.5 -2,-0.3 55,-0.1 -0.850 60.4 -30.2-140.4 101.5 22.5 23.0 4.0 68 68 A G S S- 0 0 55 -2,-0.4 63,-0.0 1,-0.2 0, 0.0 -0.576 113.8 -25.3 94.8-158.6 23.2 26.4 5.5 69 69 A P S S+ 0 0 81 0, 0.0 -1,-0.2 0, 0.0 2,-0.2 0.550 124.2 74.6 -69.7 -6.7 20.7 29.3 6.0 70 70 A b - 0 0 6 -3,-0.5 -3,-0.4 54,-0.1 2,-0.3 -0.557 68.0-150.8-103.2 169.8 18.6 27.8 3.2 71 71 A R E -B 123 0B 155 52,-2.4 52,-3.0 -2,-0.2 -5,-0.2 -0.999 29.6 -93.4-144.0 143.7 16.3 24.8 3.1 72 72 A S E -B 122 0B 7 -7,-2.1 50,-0.3 -2,-0.3 60,-0.0 -0.273 25.1-145.6 -55.9 133.4 15.3 22.3 0.4 73 73 A A S S+ 0 0 57 48,-2.3 -1,-0.2 1,-0.1 49,-0.1 0.754 83.1 23.6 -72.5 -24.7 12.0 23.3 -1.3 74 74 A K S S- 0 0 155 47,-0.3 -9,-0.4 -9,-0.1 47,-0.1 -0.943 89.9 -94.8-139.8 160.6 11.0 19.7 -1.7 75 75 A P - 0 0 53 0, 0.0 2,-0.4 0, 0.0 -11,-0.2 -0.180 35.8-125.6 -69.8 165.4 11.8 16.3 -0.0 76 76 A V E -A 63 0A 15 -13,-2.7 -13,-1.5 -4,-0.0 2,-0.4 -0.923 12.2-130.1-118.9 142.3 14.4 13.9 -1.3 77 77 A T E -A 62 0A 69 -2,-0.4 2,-0.4 -15,-0.2 -15,-0.2 -0.762 23.2-169.4 -92.9 131.0 14.0 10.2 -2.2 78 78 A E E -A 61 0A 80 -17,-3.0 -17,-2.9 -2,-0.4 2,-0.6 -0.969 10.6-149.6-123.6 134.9 16.5 7.7 -0.7 79 79 A L E -A 60 0A 20 -2,-0.4 59,-0.5 59,-0.3 2,-0.3 -0.899 15.1-168.4-106.5 122.3 16.9 4.0 -1.7 80 80 A V E -A 59 0A 42 -21,-2.7 -21,-2.2 -2,-0.6 2,-0.6 -0.810 19.6-126.6-109.6 150.0 18.0 1.6 0.9 81 81 A c E +A 58 0A 47 -2,-0.3 2,-0.3 -23,-0.2 -23,-0.2 -0.848 48.8 133.1 -99.2 118.4 19.2 -2.0 0.5 82 82 A S + 0 0 52 -25,-1.6 2,-0.3 -2,-0.6 -25,-0.2 -0.985 14.6 96.3-160.8 151.6 17.3 -4.6 2.6 83 83 A G - 0 0 34 -2,-0.3 2,-0.3 -27,-0.3 -27,-0.2 -0.964 50.0 -98.5 156.7-171.2 15.7 -8.0 2.3 84 84 A Q + 0 0 160 -29,-0.5 2,-0.3 -2,-0.3 -29,-0.1 -0.997 27.8 177.4-148.4 141.9 16.1 -11.8 2.7 85 85 A d - 0 0 49 -2,-0.3 59,-0.0 -31,-0.1 -2,-0.0 -0.873 29.4 -99.2-137.8 170.0 16.8 -14.7 0.4 86 86 A G - 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