==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=17-APR-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER CYTOKINE/INHIBITOR 19-OCT-09 3KAN . COMPND 2 MOLECULE: D-DOPACHROME TAUTOMERASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR S.ZIEROW,E.LOLIS . 351 3 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 19092.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 233 66.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 45 12.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 36 10.3 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 6 1.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 17 4.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 39 11.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 84 23.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 6 1.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 3 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 3 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 3 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A P 0 0 18 0, 0.0 37,-2.5 0, 0.0 2,-0.6 0.000 360.0 360.0 360.0 163.0 33.3 -13.2 3.7 2 2 A F E -aB 38 62A 76 60,-2.8 60,-2.4 35,-0.2 2,-0.5 -0.951 360.0-174.1-113.8 116.0 35.3 -15.4 1.4 3 3 A L E -aB 39 61A 1 35,-2.6 37,-2.2 -2,-0.6 2,-0.4 -0.940 0.8-174.6-112.7 130.5 33.3 -17.9 -0.8 4 4 A E E -aB 40 60A 62 56,-2.4 56,-2.5 -2,-0.5 2,-0.5 -0.996 2.5-169.4-128.1 127.6 35.1 -20.4 -2.9 5 5 A L E -aB 41 59A 0 35,-3.1 37,-3.0 -2,-0.4 2,-0.4 -0.959 1.9-171.2-125.0 111.4 33.2 -22.7 -5.3 6 6 A D E +aB 42 58A 39 52,-2.5 52,-2.5 -2,-0.5 2,-0.3 -0.844 16.8 170.4 -95.4 135.7 34.8 -25.6 -7.1 7 7 A T E - B 0 57A 0 35,-2.4 38,-2.3 -2,-0.4 50,-0.2 -0.999 42.2-147.4-146.5 149.2 32.8 -27.4 -9.8 8 8 A N S S+ 0 0 29 48,-1.1 49,-0.1 -2,-0.3 -1,-0.1 0.378 72.6 110.2 -90.0 1.2 33.3 -30.0 -12.5 9 9 A L S S- 0 0 2 47,-0.5 35,-2.7 1,-0.1 36,-0.3 -0.616 80.0-115.7 -64.4 132.3 30.7 -28.1 -14.5 10 10 A P > - 0 0 57 0, 0.0 3,-2.6 0, 0.0 4,-0.2 -0.312 28.9-102.5 -62.6 158.7 32.6 -26.6 -17.4 11 11 A A G > S+ 0 0 66 1,-0.3 3,-1.6 2,-0.2 -2,-0.1 0.844 122.3 61.1 -53.1 -34.9 32.7 -22.8 -17.5 12 12 A N G 3 S+ 0 0 146 1,-0.3 -1,-0.3 3,-0.0 4,-0.1 0.445 102.5 51.7 -78.4 4.6 30.1 -22.8 -20.2 13 13 A R G < S+ 0 0 148 -3,-2.6 -1,-0.3 2,-0.1 -2,-0.2 0.180 90.0 87.6-116.9 11.7 27.6 -24.6 -17.9 14 14 A V S < S- 0 0 24 -3,-1.6 3,-0.1 -4,-0.2 74,-0.1 -0.960 92.5-110.9-106.3 120.1 28.1 -22.1 -15.0 15 15 A P > - 0 0 42 0, 0.0 3,-1.7 0, 0.0 -2,-0.1 -0.218 33.8-101.5 -59.9 137.5 25.6 -19.2 -15.6 16 16 A A T 3 S+ 0 0 94 1,-0.3 -4,-0.0 2,-0.1 -5,-0.0 -0.257 107.2 22.5 -52.6 136.8 27.0 -15.9 -16.6 17 17 A G T 3> S+ 0 0 29 -3,-0.1 4,-2.1 3,-0.0 -1,-0.3 0.508 79.1 132.6 84.0 5.2 27.1 -13.5 -13.7 18 18 A L H <> + 0 0 0 -3,-1.7 4,-2.8 1,-0.2 5,-0.2 0.892 66.7 57.8 -55.6 -44.9 27.0 -16.2 -11.0 19 19 A E H > S+ 0 0 98 1,-0.2 4,-1.6 2,-0.2 -1,-0.2 0.926 109.7 43.9 -60.5 -39.0 29.8 -14.7 -9.0 20 20 A K H > S+ 0 0 172 -3,-0.2 4,-1.9 2,-0.2 -1,-0.2 0.900 113.3 50.8 -71.6 -37.9 28.0 -11.3 -8.6 21 21 A R H X S+ 0 0 92 -4,-2.1 4,-2.4 1,-0.2 -1,-0.2 0.874 107.9 53.8 -66.8 -32.3 24.7 -13.0 -7.8 22 22 A L H X S+ 0 0 0 -4,-2.8 4,-2.8 -5,-0.2 -1,-0.2 0.856 104.6 55.3 -70.9 -31.2 26.5 -15.1 -5.2 23 23 A C H X S+ 0 0 27 -4,-1.6 4,-2.0 -5,-0.2 -2,-0.2 0.939 110.8 44.8 -60.2 -47.7 27.8 -11.9 -3.6 24 24 A A H X S+ 0 0 41 -4,-1.9 4,-1.8 2,-0.2 -2,-0.2 0.908 115.0 47.9 -63.7 -42.5 24.2 -10.6 -3.3 25 25 A A H X S+ 0 0 1 -4,-2.4 4,-2.5 1,-0.2 5,-0.2 0.931 112.0 48.4 -64.5 -47.5 23.0 -13.9 -1.9 26 26 A A H X S+ 0 0 0 -4,-2.8 4,-2.8 1,-0.2 5,-0.3 0.865 106.9 57.3 -62.2 -37.3 25.8 -14.3 0.6 27 27 A A H X>S+ 0 0 11 -4,-2.0 5,-1.7 -5,-0.2 4,-1.3 0.945 112.2 41.3 -57.2 -49.0 25.2 -10.7 1.8 28 28 A S H <5S+ 0 0 86 -4,-1.8 -2,-0.2 3,-0.2 -1,-0.2 0.891 118.8 44.7 -66.4 -43.1 21.6 -11.5 2.6 29 29 A I H <5S+ 0 0 27 -4,-2.5 -2,-0.2 1,-0.2 -1,-0.2 0.918 122.6 34.0 -68.2 -47.0 22.3 -15.0 4.1 30 30 A L H <5S- 0 0 7 -4,-2.8 -1,-0.2 -5,-0.2 -2,-0.2 0.514 104.7-118.1 -92.7 -8.3 25.3 -14.0 6.3 31 31 A G T <5 + 0 0 67 -4,-1.3 -3,-0.2 -5,-0.3 -4,-0.1 0.944 69.9 130.4 68.9 48.2 24.3 -10.5 7.2 32 32 A K < - 0 0 52 -5,-1.7 -1,-0.3 -6,-0.3 2,-0.2 -0.916 67.3 -90.7-129.8 155.3 27.3 -8.9 5.5 33 33 A P > - 0 0 74 0, 0.0 3,-2.3 0, 0.0 4,-0.4 -0.501 29.2-135.5 -69.5 133.2 27.5 -6.0 3.1 34 34 A A G > S+ 0 0 51 1,-0.3 3,-1.3 -2,-0.2 -8,-0.1 0.837 104.6 61.1 -56.5 -33.2 27.4 -7.1 -0.5 35 35 A D G 3 S+ 0 0 111 1,-0.3 -1,-0.3 -11,-0.0 -11,-0.0 0.471 103.6 50.4 -76.6 -0.2 30.3 -4.8 -1.3 36 36 A R G < S+ 0 0 141 -3,-2.3 -1,-0.3 -13,-0.1 2,-0.2 0.419 85.8 109.5-108.2 -2.2 32.5 -6.8 1.1 37 37 A V < - 0 0 12 -3,-1.3 2,-0.4 -4,-0.4 -35,-0.2 -0.534 51.6-157.9 -81.2 140.7 31.7 -10.3 -0.2 38 38 A N E -a 2 0A 75 -37,-2.5 -35,-2.6 -2,-0.2 2,-0.4 -0.953 9.7-175.7-117.0 133.5 34.4 -12.2 -2.1 39 39 A V E -a 3 0A 28 -2,-0.4 2,-0.4 -37,-0.2 -35,-0.2 -0.999 7.8-175.6-132.2 133.6 33.6 -15.0 -4.5 40 40 A T E -a 4 0A 63 -37,-2.2 -35,-3.1 -2,-0.4 2,-0.5 -0.995 6.4-168.6-126.4 124.0 35.9 -17.3 -6.4 41 41 A V E -a 5 0A 37 -2,-0.4 -35,-0.2 -37,-0.2 -2,-0.0 -0.963 4.4-172.4-114.9 128.6 34.6 -19.9 -8.9 42 42 A R E +a 6 0A 96 -37,-3.0 -35,-2.4 -2,-0.5 3,-0.4 -0.898 17.9 178.2-120.7 93.4 36.8 -22.6 -10.2 43 43 A P + 0 0 47 0, 0.0 -35,-0.2 0, 0.0 -32,-0.1 -0.354 51.5 44.1 -92.5 174.6 35.0 -24.5 -13.0 44 44 A G S S+ 0 0 51 -35,-2.7 -36,-0.2 1,-0.2 2,-0.0 0.650 77.6 146.1 70.1 18.7 36.0 -27.3 -15.3 45 45 A L - 0 0 67 -38,-2.3 2,-0.7 -3,-0.4 -1,-0.2 -0.259 56.2-110.9 -80.8 168.2 37.7 -29.3 -12.5 46 46 A A + 0 0 106 -2,-0.0 2,-0.4 2,-0.0 -1,-0.1 -0.922 53.1 168.1-100.5 114.0 37.8 -33.1 -12.2 47 47 A M - 0 0 31 -2,-0.7 2,-0.4 6,-0.2 -39,-0.0 -0.966 34.3-168.4-134.4 146.8 35.6 -34.0 -9.2 48 48 A A - 0 0 59 -2,-0.4 2,-0.5 5,-0.1 5,-0.2 -0.991 13.2-169.7-120.7 135.8 34.0 -36.8 -7.4 49 49 A L B > S-D 52 0B 2 3,-2.5 3,-1.9 -2,-0.4 5,-0.2 -0.999 79.4 -8.5-125.9 125.9 31.4 -35.9 -4.7 50 50 A S T 3 S- 0 0 106 -2,-0.5 -1,-0.2 1,-0.3 3,-0.1 0.925 133.7 -54.7 48.1 49.1 30.2 -38.8 -2.5 51 51 A G T 3 S+ 0 0 79 1,-0.1 2,-0.4 -3,-0.1 -1,-0.3 0.363 116.5 108.5 76.2 -3.8 32.1 -41.1 -4.9 52 52 A S B < -D 49 0B 38 -3,-1.9 -3,-2.5 1,-0.1 -1,-0.1 -0.896 55.6-156.0-114.9 138.1 30.4 -39.9 -8.1 53 53 A T + 0 0 103 -2,-0.4 -6,-0.2 -5,-0.2 3,-0.1 0.297 56.8 121.0 -93.8 9.5 31.8 -37.9 -11.0 54 54 A E S S- 0 0 121 -5,-0.2 -5,-0.1 1,-0.2 -46,-0.1 -0.232 85.4 -60.4 -59.3 161.6 28.4 -36.6 -12.1 55 55 A P S S+ 0 0 36 0, 0.0 2,-0.3 0, 0.0 -1,-0.2 -0.167 77.8 149.2 -50.2 137.8 28.1 -32.7 -12.0 56 56 A C - 0 0 0 -3,-0.1 -48,-1.1 34,-0.1 -47,-0.5 -0.942 31.6-142.6-158.5 172.5 28.7 -31.4 -8.5 57 57 A A E -Bc 7 95A 0 37,-2.3 39,-1.4 -2,-0.3 2,-0.5 -0.994 2.4-153.3-150.7 148.0 30.0 -28.4 -6.6 58 58 A Q E -Bc 6 96A 37 -52,-2.5 -52,-2.5 -2,-0.3 2,-0.4 -0.984 15.6-165.9-122.0 118.8 31.9 -27.7 -3.4 59 59 A L E -Bc 5 97A 0 37,-2.7 39,-2.2 -2,-0.5 2,-0.4 -0.890 3.7-167.9-106.4 136.4 31.4 -24.4 -1.6 60 60 A S E -Bc 4 98A 12 -56,-2.5 -56,-2.4 -2,-0.4 2,-0.4 -0.979 3.0-167.5-118.8 137.7 33.6 -23.1 1.2 61 61 A I E -Bc 3 99A 0 37,-2.7 39,-2.9 -2,-0.4 2,-0.4 -0.986 5.4-178.6-128.6 119.3 32.6 -20.1 3.3 62 62 A S E +Bc 2 100A 14 -60,-2.4 -60,-2.8 -2,-0.4 2,-0.3 -0.974 19.3 149.0-121.8 128.8 35.1 -18.3 5.5 63 63 A S E - c 0 101A 2 37,-1.5 39,-1.9 -2,-0.4 2,-0.4 -0.998 45.7-103.6-159.3 151.9 33.9 -15.4 7.6 64 64 A I E S- c 0 102A 53 -2,-0.3 2,-1.3 37,-0.2 39,-0.1 -0.650 92.4 -17.6 -77.3 130.0 34.3 -13.5 10.9 65 65 A G S S+ 0 0 67 37,-0.6 3,-0.3 -2,-0.4 -1,-0.1 -0.074 120.7 69.2 83.9 -37.8 31.8 -14.1 13.6 66 66 A V S S+ 0 0 38 -2,-1.3 3,-0.2 1,-0.2 -1,-0.2 0.459 87.9 55.0-109.6 -3.9 28.9 -15.7 11.7 67 67 A V S S+ 0 0 1 -4,-0.4 -1,-0.2 1,-0.1 -6,-0.1 0.004 79.9 93.4-119.3 31.0 29.9 -19.2 10.6 68 68 A G S S+ 0 0 51 -3,-0.3 2,-0.3 32,-0.1 -1,-0.1 0.456 71.4 66.3-103.7 -4.3 31.0 -20.7 14.0 69 69 A T S > S- 0 0 55 -3,-0.2 4,-2.2 1,-0.1 5,-0.2 -0.905 70.1-133.5-121.6 152.7 27.9 -22.4 15.3 70 70 A A H > S+ 0 0 70 -2,-0.3 4,-2.3 1,-0.2 5,-0.2 0.895 107.5 52.2 -64.2 -42.3 25.8 -25.4 14.2 71 71 A E H > S+ 0 0 114 2,-0.2 4,-1.3 1,-0.2 -1,-0.2 0.915 114.5 41.4 -66.7 -43.4 22.5 -23.6 14.6 72 72 A D H > S+ 0 0 67 2,-0.2 4,-2.6 1,-0.2 -1,-0.2 0.890 114.6 51.7 -63.0 -49.1 23.6 -20.6 12.4 73 73 A N H X S+ 0 0 26 -4,-2.2 4,-2.9 1,-0.2 -2,-0.2 0.854 102.9 59.1 -66.7 -31.6 25.4 -22.8 9.9 74 74 A R H X S+ 0 0 165 -4,-2.3 4,-2.2 2,-0.2 -1,-0.2 0.935 110.0 44.2 -55.3 -49.1 22.2 -24.9 9.5 75 75 A S H X S+ 0 0 58 -4,-1.3 4,-1.9 2,-0.2 -2,-0.2 0.933 113.7 49.0 -63.1 -47.0 20.4 -21.8 8.5 76 76 A H H X S+ 0 0 17 -4,-2.6 4,-2.7 1,-0.2 5,-0.2 0.925 110.0 53.0 -58.9 -44.4 23.1 -20.6 6.2 77 77 A S H X S+ 0 0 32 -4,-2.9 4,-2.8 1,-0.2 5,-0.3 0.934 105.8 52.7 -57.2 -48.2 23.3 -24.1 4.6 78 78 A A H X S+ 0 0 63 -4,-2.2 4,-2.0 1,-0.2 -1,-0.2 0.927 113.4 44.1 -54.5 -46.9 19.6 -24.1 3.8 79 79 A H H X S+ 0 0 92 -4,-1.9 4,-2.1 2,-0.2 -1,-0.2 0.890 113.7 48.5 -70.2 -40.1 19.8 -20.8 2.0 80 80 A F H X S+ 0 0 0 -4,-2.7 4,-2.8 2,-0.2 5,-0.2 0.869 110.0 52.7 -69.2 -35.1 23.0 -21.5 0.1 81 81 A F H X S+ 0 0 44 -4,-2.8 4,-2.6 -5,-0.2 5,-0.3 0.914 108.6 50.7 -62.8 -42.8 21.6 -24.9 -1.1 82 82 A E H X S+ 0 0 39 -4,-2.0 4,-1.4 -5,-0.3 5,-0.2 0.941 114.3 44.8 -57.1 -47.3 18.5 -23.1 -2.3 83 83 A F H X S+ 0 0 19 -4,-2.1 4,-2.4 1,-0.2 -2,-0.2 0.947 118.7 39.7 -61.8 -52.8 20.6 -20.6 -4.2 84 84 A L H X S+ 0 0 0 -4,-2.8 4,-2.6 2,-0.2 6,-0.4 0.845 108.9 57.5 -75.1 -36.8 23.1 -23.1 -5.7 85 85 A T H X>S+ 0 0 26 -4,-2.6 5,-1.4 -5,-0.2 4,-0.8 0.937 115.7 38.7 -57.1 -45.2 20.7 -25.9 -6.6 86 86 A K H <5S+ 0 0 116 -4,-1.4 3,-0.2 -5,-0.3 -2,-0.2 0.927 118.0 47.2 -72.8 -44.6 18.7 -23.5 -8.8 87 87 A E H <5S+ 0 0 44 -4,-2.4 -2,-0.2 -5,-0.2 -3,-0.2 0.903 123.3 32.5 -63.2 -41.7 21.7 -21.6 -10.2 88 88 A L H <5S- 0 0 9 -4,-2.6 -1,-0.2 -5,-0.2 -2,-0.2 0.464 102.4-124.7 -96.4 -3.8 23.7 -24.6 -11.2 89 89 A A T <5 + 0 0 89 -4,-0.8 2,-0.4 -3,-0.2 -3,-0.2 0.919 63.6 142.5 56.4 46.4 20.8 -26.9 -12.0 90 90 A L < - 0 0 17 -5,-1.4 -1,-0.2 -6,-0.4 -2,-0.1 -0.913 52.2-117.5-116.5 144.4 22.2 -29.4 -9.4 91 91 A G > - 0 0 36 -2,-0.4 3,-2.2 -3,-0.1 4,-0.1 -0.366 32.6-108.1 -69.4 158.7 20.4 -31.7 -7.0 92 92 A Q G > S+ 0 0 83 1,-0.3 3,-0.8 2,-0.2 -1,-0.1 0.711 118.9 63.8 -62.2 -22.3 20.9 -31.3 -3.3 93 93 A D G 3 S+ 0 0 88 1,-0.2 -1,-0.3 3,-0.0 -2,-0.0 0.517 96.8 59.0 -75.3 -6.3 22.9 -34.5 -3.3 94 94 A R G < S+ 0 0 26 -3,-2.2 -37,-2.3 -38,-0.1 2,-0.4 0.200 95.6 69.0-113.1 14.1 25.5 -32.9 -5.6 95 95 A I E < +c 57 0A 2 -3,-0.8 2,-0.3 -39,-0.2 -37,-0.2 -0.993 51.1 178.6-133.5 138.9 26.6 -30.0 -3.3 96 96 A L E -c 58 0A 78 -39,-1.4 -37,-2.7 -2,-0.4 2,-0.4 -0.968 11.3-154.8-132.2 154.9 28.5 -29.8 -0.1 97 97 A I E -c 59 0A 28 -2,-0.3 2,-0.4 -39,-0.2 -37,-0.2 -0.962 3.6-161.0-125.6 143.6 29.6 -26.8 2.0 98 98 A R E -c 60 0A 120 -39,-2.2 -37,-2.7 -2,-0.4 2,-0.4 -0.992 11.0-151.7-121.6 138.3 32.4 -26.2 4.5 99 99 A F E -c 61 0A 45 -2,-0.4 -37,-0.2 -39,-0.2 -39,-0.0 -0.925 11.6-175.0-111.1 130.6 32.3 -23.4 7.0 100 100 A F E -c 62 0A 87 -39,-2.9 -37,-1.5 -2,-0.4 -32,-0.1 -0.914 16.1-144.1-131.1 105.4 35.5 -21.8 8.3 101 101 A P E -c 63 0A 79 0, 0.0 2,-0.3 0, 0.0 -37,-0.2 -0.415 20.4-162.9 -62.7 141.7 35.5 -19.1 11.0 102 102 A L E -c 64 0A 32 -39,-1.9 -37,-0.6 -2,-0.1 2,-0.3 -0.902 8.7-142.9-120.0 154.8 38.2 -16.5 10.6 103 103 A E > - 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