==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER TRANSFERASE 06-MAR-02 1L4G . COMPND 2 MOLECULE: NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE . SOURCE 2 ORGANISM_SCIENTIFIC: SALMONELLA ENTERICA; . AUTHOR C.-G.CHEONG,J.ESCALANTE-SEMERENA,I.RAYMENT . 346 1 1 1 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 12953.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 257 74.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 32 9.2 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 19 5.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 51 14.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 130 37.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 8 2.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 1 0 1 2 1 0 1 2 1 0 2 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 2 3 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 4 A L > 0 0 58 0, 0.0 4,-2.8 0, 0.0 5,-0.2 0.000 360.0 360.0 360.0 -47.7 48.3 11.7 14.1 2 5 A H H > + 0 0 78 1,-0.2 4,-1.4 2,-0.2 5,-0.1 0.859 360.0 51.0 -63.0 -32.9 46.1 9.7 11.7 3 6 A A H > S+ 0 0 47 2,-0.2 4,-1.8 1,-0.2 -1,-0.2 0.913 108.0 52.3 -67.2 -44.0 44.0 9.0 14.8 4 7 A L H 4 S+ 0 0 26 1,-0.2 3,-0.2 2,-0.2 -2,-0.2 0.929 111.9 44.2 -56.0 -50.5 44.0 12.7 15.5 5 8 A L H >< S+ 0 0 43 -4,-2.8 3,-0.5 1,-0.2 -1,-0.2 0.753 111.0 55.8 -68.2 -26.6 42.7 13.6 12.0 6 9 A R H 3< S+ 0 0 176 -4,-1.4 -1,-0.2 -5,-0.2 -2,-0.2 0.821 105.5 51.6 -76.1 -32.0 40.2 10.7 12.1 7 10 A D T 3< S+ 0 0 64 -4,-1.8 -1,-0.2 -3,-0.2 -2,-0.2 0.328 71.1 126.9 -90.4 7.7 38.6 12.0 15.3 8 11 A I < - 0 0 15 -3,-0.5 244,-0.2 -4,-0.2 245,-0.1 -0.531 63.2-124.3 -66.2 117.9 37.9 15.6 14.2 9 12 A P - 0 0 37 0, 0.0 245,-0.1 0, 0.0 -1,-0.1 -0.292 13.9-125.0 -67.6 146.2 34.2 16.0 15.0 10 13 A A - 0 0 76 1,-0.1 2,-0.0 36,-0.0 267,-0.0 -0.489 42.9 -84.2 -82.5 161.5 31.7 17.1 12.3 11 14 A P - 0 0 55 0, 0.0 2,-1.2 0, 0.0 35,-0.2 -0.351 40.5-112.4 -67.8 147.1 29.5 20.2 13.0 12 15 A D > - 0 0 61 33,-3.2 4,-2.0 1,-0.2 3,-0.3 -0.667 31.4-177.1 -85.0 93.2 26.3 19.8 15.0 13 16 A A H > S+ 0 0 71 -2,-1.2 4,-2.4 1,-0.2 -1,-0.2 0.802 80.3 59.9 -59.1 -31.8 23.5 20.5 12.5 14 17 A E H > S+ 0 0 107 2,-0.2 4,-1.7 1,-0.2 -1,-0.2 0.920 108.0 42.8 -65.3 -44.3 20.9 20.0 15.2 15 18 A A H > S+ 0 0 0 -3,-0.3 4,-2.0 2,-0.2 -1,-0.2 0.866 112.4 55.0 -69.3 -36.3 22.3 22.8 17.4 16 19 A M H X S+ 0 0 53 -4,-2.0 4,-2.6 1,-0.2 -2,-0.2 0.920 106.7 49.9 -63.5 -42.9 22.8 25.0 14.3 17 20 A A H X S+ 0 0 66 -4,-2.4 4,-2.0 1,-0.2 -1,-0.2 0.892 111.1 48.7 -63.0 -40.8 19.1 24.6 13.3 18 21 A R H X S+ 0 0 131 -4,-1.7 4,-1.9 2,-0.2 -1,-0.2 0.859 110.4 53.9 -66.5 -33.2 18.0 25.6 16.9 19 22 A T H X S+ 0 0 4 -4,-2.0 4,-2.7 2,-0.2 -2,-0.2 0.963 107.4 48.1 -64.6 -51.9 20.4 28.6 16.6 20 23 A Q H X S+ 0 0 72 -4,-2.6 4,-2.5 1,-0.2 -2,-0.2 0.906 110.4 52.0 -55.9 -46.0 18.9 29.9 13.4 21 24 A Q H X S+ 0 0 67 -4,-2.0 4,-1.0 1,-0.2 -1,-0.2 0.915 111.7 46.6 -57.5 -46.1 15.3 29.6 14.7 22 25 A H H >< S+ 0 0 66 -4,-1.9 3,-0.5 1,-0.2 4,-0.4 0.917 112.0 50.0 -63.8 -44.3 16.2 31.6 17.8 23 26 A I H >< S+ 0 0 0 -4,-2.7 3,-1.4 1,-0.2 -2,-0.2 0.891 106.1 56.3 -62.3 -40.4 18.1 34.3 15.9 24 27 A D H 3< S+ 0 0 65 -4,-2.5 -1,-0.2 1,-0.3 4,-0.2 0.776 105.3 53.3 -63.3 -27.1 15.2 34.7 13.5 25 28 A G T << S+ 0 0 28 -4,-1.0 313,-2.2 -3,-0.5 314,-0.4 0.480 85.2 114.0 -88.3 -1.4 12.9 35.4 16.4 26 29 A L B < S-A 337 0A 0 -3,-1.4 2,-2.8 -4,-0.4 311,-0.3 -0.252 88.7 -83.3 -69.8 158.4 15.0 38.2 17.9 27 30 A L S S+ 0 0 76 309,-2.7 -1,-0.1 311,-0.0 309,-0.1 -0.293 100.8 72.9 -62.5 71.5 13.9 41.8 18.1 28 31 A K S S- 0 0 14 -2,-2.8 310,-0.1 -4,-0.2 317,-0.1 -0.970 94.3 -73.7-174.4 160.4 14.9 42.7 14.5 29 32 A P S > S- 0 0 78 0, 0.0 3,-2.5 0, 0.0 4,-0.3 -0.440 71.0 -89.7 -63.7 136.5 14.0 42.2 10.8 30 33 A P T 3 S+ 0 0 73 0, 0.0 -6,-0.1 0, 0.0 -5,-0.0 -0.230 110.2 4.2 -50.3 133.4 15.0 38.7 9.9 31 34 A G T > S+ 0 0 41 -3,-0.1 3,-1.9 1,-0.1 6,-0.1 0.405 90.1 126.9 71.4 -0.5 18.6 38.5 8.7 32 35 A S T < + 0 0 61 -3,-2.5 -1,-0.1 1,-0.3 0, 0.0 0.732 68.0 58.0 -61.5 -24.0 19.2 42.2 9.4 33 36 A L T > S- 0 0 59 -4,-0.3 3,-2.1 1,-0.2 4,-0.5 0.284 87.9-175.4 -90.9 12.7 22.3 41.5 11.5 34 37 A G T X> + 0 0 36 -3,-1.9 4,-1.6 1,-0.3 3,-1.3 0.070 62.7 11.0 37.0-120.5 23.9 39.7 8.5 35 38 A R H 3> S+ 0 0 110 1,-0.3 4,-2.1 2,-0.2 -1,-0.3 0.657 121.1 67.6 -63.9 -16.3 27.2 38.0 9.0 36 39 A L H <> S+ 0 0 50 -3,-2.1 4,-1.4 2,-0.2 -1,-0.3 0.846 104.6 44.0 -71.8 -30.7 26.9 38.4 12.8 37 40 A E H <> S+ 0 0 8 -3,-1.3 4,-1.8 -4,-0.5 -2,-0.2 0.897 111.8 51.7 -76.9 -43.9 24.0 35.9 12.6 38 41 A T H X S+ 0 0 90 -4,-1.6 4,-2.0 1,-0.2 -2,-0.2 0.894 109.6 51.6 -59.3 -40.7 25.9 33.6 10.3 39 42 A L H X S+ 0 0 1 -4,-2.1 4,-2.3 1,-0.2 -1,-0.2 0.914 106.1 53.2 -63.3 -44.6 28.8 33.7 12.7 40 43 A A H X S+ 0 0 0 -4,-1.4 4,-1.8 1,-0.2 -1,-0.2 0.863 109.7 49.1 -59.5 -37.2 26.5 32.8 15.7 41 44 A V H X S+ 0 0 17 -4,-1.8 4,-1.0 2,-0.2 -1,-0.2 0.913 108.0 53.3 -70.0 -41.3 25.2 29.8 13.8 42 45 A Q H >X S+ 0 0 42 -4,-2.0 3,-0.8 1,-0.2 4,-0.5 0.932 109.7 48.8 -57.6 -47.6 28.7 28.6 12.9 43 46 A L H >< S+ 0 0 1 -4,-2.3 3,-1.5 1,-0.3 6,-0.3 0.902 105.6 56.9 -59.3 -45.0 29.8 28.7 16.6 44 47 A A H 3< S+ 0 0 0 -4,-1.8 -1,-0.3 1,-0.3 -2,-0.2 0.733 100.9 59.6 -62.0 -21.2 26.7 26.8 17.7 45 48 A G H << S+ 0 0 1 -4,-1.0 -33,-3.2 -3,-0.8 -1,-0.3 0.684 81.6 97.8 -80.6 -16.8 27.7 24.0 15.4 46 49 A M X< - 0 0 2 -3,-1.5 3,-2.9 -4,-0.5 6,-0.2 -0.643 68.7-146.9 -79.1 108.6 31.1 23.5 17.1 47 50 A P G > S+ 0 0 53 0, 0.0 3,-1.3 0, 0.0 -1,-0.1 0.738 94.9 62.9 -43.6 -36.2 30.8 20.5 19.6 48 51 A G G 3 S+ 0 0 26 206,-1.9 207,-0.2 1,-0.2 206,-0.1 0.704 94.2 62.3 -67.9 -17.7 33.3 22.1 22.0 49 52 A L G X S- 0 0 2 -3,-2.9 3,-0.8 205,-0.4 -1,-0.2 0.273 110.5-116.2 -92.5 11.7 30.9 25.1 22.6 50 53 A N T < - 0 0 122 -3,-1.3 -2,-0.1 1,-0.2 -6,-0.1 0.942 64.7 -57.5 55.3 59.0 28.2 23.0 24.1 51 54 A G T 3 S+ 0 0 23 -5,-0.2 -1,-0.2 -7,-0.1 -7,-0.1 0.640 120.2 78.4 50.8 21.8 25.4 23.5 21.5 52 55 A T S < S- 0 0 31 -3,-0.8 2,-0.7 -6,-0.2 -1,-0.1 -0.994 88.4-100.0-156.1 148.5 25.4 27.3 21.9 53 56 A P + 0 0 0 0, 0.0 2,-0.3 0, 0.0 280,-0.1 -0.583 63.9 142.8 -72.5 113.9 27.4 30.3 20.7 54 57 A Q - 0 0 64 -2,-0.7 2,-0.4 111,-0.1 -2,-0.1 -0.971 39.4-149.8-149.1 161.2 29.6 31.2 23.7 55 58 A V + 0 0 32 -2,-0.3 3,-0.1 271,-0.1 109,-0.1 -0.959 19.9 164.2-139.1 117.5 33.1 32.4 24.6 56 59 A G - 0 0 33 1,-0.4 108,-0.2 -2,-0.4 2,-0.2 0.574 63.8 -5.8 -96.7-111.0 34.9 31.5 27.8 57 60 A E E -b 164 0B 120 106,-2.3 108,-2.3 103,-0.1 109,-1.4 -0.515 67.9-146.7 -84.4 156.6 38.6 32.1 28.0 58 61 A K E -b 166 0B 24 46,-0.4 48,-2.5 106,-0.2 2,-0.3 -0.970 15.0-177.3-127.0 139.5 40.6 33.4 25.0 59 62 A A E -bc 167 106B 0 107,-2.0 109,-1.8 -2,-0.4 2,-0.5 -0.992 16.0-154.5-138.2 144.6 44.2 32.6 24.0 60 63 A V E -bc 168 107B 0 46,-2.8 48,-3.4 -2,-0.3 2,-0.6 -0.965 14.1-156.1-119.0 113.1 46.4 33.7 21.2 61 64 A L E -bc 169 108B 0 107,-2.3 109,-1.9 -2,-0.5 2,-0.7 -0.807 6.3-164.2 -93.3 119.8 49.2 31.2 20.3 62 65 A V E -bc 170 109B 0 46,-3.5 48,-3.1 -2,-0.6 2,-0.6 -0.897 4.3-156.4-109.1 111.2 52.2 32.8 18.6 63 66 A M E -bc 171 110B 0 107,-2.7 109,-1.7 -2,-0.7 2,-0.4 -0.741 13.9-166.9 -87.0 120.7 54.6 30.5 16.8 64 67 A C E +bc 172 111B 0 46,-3.1 48,-2.6 -2,-0.6 49,-0.9 -0.905 20.1 136.7-114.9 137.9 58.1 31.9 16.5 65 68 A A E - c 0 113B 0 107,-2.2 49,-0.3 -2,-0.4 2,-0.2 -0.979 40.3-118.2-168.7 159.5 60.9 30.6 14.3 66 69 A D - 0 0 2 47,-2.4 65,-1.7 -2,-0.3 2,-0.4 -0.671 23.3-139.1-104.4 161.1 63.7 31.6 12.0 67 70 A H B > -g 131 0C 2 107,-0.5 3,-1.6 63,-0.3 4,-0.2 -0.971 11.7-144.3-126.5 135.1 64.1 30.6 8.3 68 71 A G G > S+ 0 0 12 63,-1.2 3,-2.1 -2,-0.4 65,-0.3 0.839 97.2 71.8 -62.8 -32.5 67.2 29.7 6.4 69 72 A V G > >S+ 0 0 2 63,-0.4 3,-2.2 1,-0.3 5,-0.6 0.584 72.6 87.7 -61.5 -9.5 66.0 31.4 3.3 70 73 A W G X 5S+ 0 0 64 -3,-1.6 3,-1.5 1,-0.3 5,-0.4 0.850 78.1 66.1 -57.4 -31.5 66.7 34.7 5.1 71 74 A D G < 5S+ 0 0 118 -3,-2.1 -1,-0.3 1,-0.3 -2,-0.2 0.564 83.8 73.1 -68.1 -8.7 70.2 34.3 3.6 72 75 A E G < 5S- 0 0 47 -3,-2.2 -1,-0.3 -4,-0.1 -2,-0.2 0.340 114.4-110.5 -87.6 7.9 68.7 34.8 0.1 73 76 A G T < 5S+ 0 0 46 -3,-1.5 -2,-0.1 2,-0.1 137,-0.1 0.794 78.8 131.3 70.9 29.2 68.2 38.5 0.8 74 77 A V < + 0 0 3 -5,-0.6 2,-0.4 -4,-0.3 101,-0.1 0.458 63.2 50.3 -92.4 -0.9 64.4 38.2 0.8 75 78 A A - 0 0 21 -5,-0.4 -1,-0.1 99,-0.1 -2,-0.1 -0.995 57.0-161.1-140.8 134.0 63.9 40.2 4.1 76 79 A V + 0 0 81 -2,-0.4 -1,-0.1 124,-0.3 125,-0.0 0.473 66.1 97.5 -91.3 -3.1 65.3 43.5 5.2 77 80 A S S S- 0 0 29 1,-0.1 -2,-0.1 2,-0.0 123,-0.0 -0.716 87.8-104.2 -86.5 136.8 64.8 43.0 9.0 78 81 A P > - 0 0 71 0, 0.0 3,-1.7 0, 0.0 4,-0.3 -0.290 29.1-122.0 -56.1 143.0 67.9 41.8 10.9 79 82 A K T > S+ 0 0 40 1,-0.3 3,-1.4 2,-0.2 4,-0.4 0.822 108.0 64.7 -59.4 -33.6 67.5 38.1 11.6 80 83 A I T 3> S+ 0 0 100 1,-0.3 4,-2.3 2,-0.2 -1,-0.3 0.640 78.2 85.0 -66.7 -13.3 67.9 38.7 15.4 81 84 A V H <> S+ 0 0 41 -3,-1.7 4,-2.9 1,-0.2 5,-0.3 0.850 83.1 60.9 -58.8 -31.0 64.6 40.6 15.4 82 85 A T H <> S+ 0 0 0 -3,-1.4 4,-2.1 -4,-0.3 -1,-0.2 0.968 109.4 39.4 -59.1 -54.1 62.8 37.3 15.7 83 86 A A H > S+ 0 0 17 -4,-0.4 4,-1.8 2,-0.2 -2,-0.2 0.883 117.4 49.5 -62.2 -42.5 64.5 36.5 19.1 84 87 A I H X S+ 0 0 89 -4,-2.3 4,-2.3 2,-0.2 -2,-0.2 0.940 113.6 45.3 -63.3 -48.3 64.3 40.1 20.4 85 88 A Q H X S+ 0 0 43 -4,-2.9 4,-1.4 1,-0.2 -2,-0.2 0.843 108.5 56.7 -65.2 -35.5 60.6 40.4 19.5 86 89 A A H X S+ 0 0 0 -4,-2.1 4,-0.7 -5,-0.3 -1,-0.2 0.914 107.6 49.6 -62.9 -39.5 59.8 37.0 21.0 87 90 A A H >< S+ 0 0 14 -4,-1.8 3,-1.8 1,-0.2 4,-0.4 0.955 106.8 54.0 -63.1 -48.8 61.4 38.3 24.2 88 91 A N H ><>S+ 0 0 38 -4,-2.3 3,-1.5 1,-0.3 5,-1.4 0.779 96.3 68.7 -56.1 -27.3 59.2 41.4 24.1 89 92 A M H ><5S+ 0 0 8 -4,-1.4 3,-0.9 1,-0.3 -1,-0.3 0.856 96.1 53.6 -59.3 -34.7 56.2 39.2 23.8 90 93 A T T <<5S+ 0 0 65 -3,-1.8 -1,-0.3 -4,-0.7 -2,-0.2 0.550 106.6 53.4 -77.7 -8.0 56.9 38.1 27.4 91 94 A R T < 5S- 0 0 155 -3,-1.5 -1,-0.2 -4,-0.4 -2,-0.2 0.400 107.4-122.9-105.1 -1.5 56.9 41.8 28.5 92 95 A G T < 5S+ 0 0 42 -3,-0.9 -3,-0.2 -4,-0.4 -2,-0.1 0.796 79.2 115.1 64.6 31.9 53.5 42.6 27.0 93 96 A T < + 0 0 93 -5,-1.4 -4,-0.1 4,-0.1 2,-0.1 0.471 47.6 94.7-109.0 -6.0 54.9 45.4 24.8 94 97 A T S > S- 0 0 7 -6,-0.4 4,-2.1 -9,-0.1 5,-0.2 -0.342 87.0-102.8 -83.3 167.9 54.2 44.0 21.3 95 98 A G H > S+ 0 0 27 1,-0.2 4,-2.5 2,-0.2 5,-0.2 0.921 121.1 45.8 -55.9 -51.0 51.3 44.7 19.1 96 99 A V H > S+ 0 0 0 1,-0.2 4,-2.7 2,-0.2 5,-0.3 0.871 110.1 56.6 -63.8 -33.7 49.5 41.4 19.7 97 100 A C H > S+ 0 0 13 2,-0.2 4,-2.0 1,-0.2 -1,-0.2 0.922 111.2 42.4 -61.3 -45.0 50.1 41.8 23.5 98 101 A V H X S+ 0 0 79 -4,-2.1 4,-1.6 2,-0.2 -2,-0.2 0.901 117.5 45.0 -69.6 -43.4 48.4 45.2 23.5 99 102 A L H X S+ 0 0 51 -4,-2.5 4,-1.1 -5,-0.2 -2,-0.2 0.859 113.1 51.5 -71.0 -33.4 45.5 44.1 21.3 100 103 A A H ><>S+ 0 0 1 -4,-2.7 5,-2.7 -5,-0.2 3,-0.5 0.933 107.7 52.3 -67.0 -44.7 45.0 40.8 23.2 101 104 A A H ><5S+ 0 0 70 -4,-2.0 3,-1.0 1,-0.3 -1,-0.2 0.876 106.1 53.8 -58.0 -39.2 44.9 42.7 26.5 102 105 A Q H 3<5S+ 0 0 169 -4,-1.6 -1,-0.3 1,-0.3 -2,-0.2 0.819 112.9 44.5 -65.4 -30.0 42.2 44.9 25.1 103 106 A A T <<5S- 0 0 9 -4,-1.1 -1,-0.3 -3,-0.5 -2,-0.2 0.374 114.7-115.8 -94.4 2.0 40.2 41.8 24.2 104 107 A G T < 5 + 0 0 49 -3,-1.0 -46,-0.4 -4,-0.4 2,-0.3 0.845 69.6 139.0 66.8 32.6 40.9 40.1 27.6 105 108 A A < - 0 0 13 -5,-2.7 2,-0.5 -6,-0.1 -1,-0.2 -0.776 50.8-126.4-109.4 156.1 42.9 37.3 25.9 106 109 A K E -c 59 0B 51 -48,-2.5 -46,-2.8 -2,-0.3 2,-0.4 -0.856 19.1-137.9-104.1 135.5 46.1 35.7 27.0 107 110 A V E -c 60 0B 39 -2,-0.5 2,-0.6 -48,-0.2 -46,-0.2 -0.763 11.0-160.9 -94.2 132.6 49.1 35.5 24.7 108 111 A H E -c 61 0B 42 -48,-3.4 -46,-3.5 -2,-0.4 2,-0.7 -0.949 5.4-156.2-115.4 112.3 51.1 32.3 24.4 109 112 A V E -c 62 0B 11 -2,-0.6 14,-2.5 12,-0.2 2,-0.5 -0.787 14.3-173.0 -90.8 115.5 54.6 32.7 23.0 110 113 A I E -cd 63 123B 0 -48,-3.1 -46,-3.1 -2,-0.7 2,-0.7 -0.939 15.0-151.6-116.5 120.9 55.8 29.4 21.5 111 114 A D E +cd 64 124B 3 12,-3.2 14,-2.7 -2,-0.5 -46,-0.2 -0.806 25.7 162.0 -90.6 114.9 59.3 28.9 20.2 112 115 A V E S- 0 0 0 -48,-2.6 15,-2.2 -2,-0.7 16,-0.4 0.369 79.5 -16.0-112.0 1.7 59.3 26.3 17.5 113 116 A G E S+c 65 0B 0 -49,-0.9 -47,-2.4 13,-0.3 17,-0.9 0.382 71.0 165.8 163.3 41.1 62.7 27.2 15.9 114 117 A I - 0 0 0 -49,-0.3 2,-1.7 -50,-0.3 16,-0.0 -0.542 39.5-128.4 -74.1 136.8 64.2 30.5 16.8 115 118 A D S S+ 0 0 65 14,-0.2 2,-0.3 -2,-0.2 -32,-0.1 -0.588 80.9 64.8 -87.8 74.7 67.9 30.7 15.8 116 119 A A S S- 0 0 22 -2,-1.7 3,-0.1 -33,-0.1 14,-0.1 -0.948 96.7 -57.0-173.2 178.0 69.2 31.9 19.1 117 120 A E S S- 0 0 148 -2,-0.3 -3,-0.0 1,-0.1 -2,-0.0 -0.351 73.2 -78.4 -70.3 156.5 69.5 30.7 22.7 118 121 A P - 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0 0 12 -4,-2.6 -1,-0.2 1,-0.1 5,-0.1 -0.638 35.3-107.3 -77.1 128.6 60.8 45.0 1.4 203 206 A P > - 0 0 63 0, 0.0 3,-2.0 0, 0.0 4,-0.4 -0.249 21.3-121.6 -56.7 141.4 62.0 47.6 -1.2 204 207 A P G > S+ 0 0 87 0, 0.0 3,-1.1 0, 0.0 4,-0.4 0.808 111.3 62.9 -54.0 -31.6 60.3 47.4 -4.6 205 208 A S G 3 S+ 0 0 105 1,-0.2 4,-0.3 2,-0.1 3,-0.2 0.725 101.0 51.8 -68.0 -21.8 63.7 46.9 -6.2 206 209 A R G <> S+ 0 0 28 -3,-2.0 4,-1.4 1,-0.2 -1,-0.2 0.417 82.7 90.3 -96.5 1.7 64.2 43.6 -4.3 207 210 A I H <> S+ 0 0 42 -3,-1.1 4,-2.3 -4,-0.4 5,-0.2 0.916 79.6 59.8 -63.1 -45.9 60.9 41.9 -5.2 208 211 A D H > S+ 0 0 130 -4,-0.4 4,-2.3 1,-0.2 -1,-0.2 0.913 104.8 49.3 -49.1 -49.6 62.3 40.3 -8.4 209 212 A N H > S+ 0 0 66 -4,-0.3 4,-2.5 1,-0.2 -1,-0.2 0.908 108.4 53.6 -58.7 -42.3 64.8 38.3 -6.4 210 213 A K H X S+ 0 0 2 -4,-1.4 4,-2.3 1,-0.2 -1,-0.2 0.919 108.7 49.6 -59.0 -43.8 62.1 37.2 -3.9 211 214 A V H X S+ 0 0 11 -4,-2.3 4,-2.2 1,-0.2 -1,-0.2 0.918 110.1 49.9 -62.5 -43.9 60.0 35.8 -6.8 212 215 A D H X S+ 0 0 42 -4,-2.3 4,-2.5 1,-0.2 -1,-0.2 0.908 109.8 51.7 -61.8 -41.4 63.0 34.0 -8.3 213 216 A V H X S+ 0 0 0 -4,-2.5 4,-2.5 2,-0.2 -2,-0.2 0.927 108.8 50.3 -60.3 -46.5 63.7 32.4 -4.8 214 217 A V H X S+ 0 0 0 -4,-2.3 4,-1.8 1,-0.2 -1,-0.2 0.918 111.8 47.8 -58.1 -45.3 60.1 31.2 -4.5 215 218 A R H X S+ 0 0 114 -4,-2.2 4,-2.9 1,-0.2 -1,-0.2 0.909 111.1 51.2 -62.1 -43.5 60.2 29.6 -7.9 216 219 A R H X S+ 0 0 92 -4,-2.5 4,-2.6 1,-0.2 5,-0.3 0.887 106.7 54.0 -60.9 -42.3 63.6 28.0 -7.1 217 220 A A H X S+ 0 0 0 -4,-2.5 4,-1.8 2,-0.2 -1,-0.2 0.909 113.5 43.1 -59.6 -42.2 62.2 26.6 -3.9 218 221 A I H X S+ 0 0 37 -4,-1.8 4,-2.9 2,-0.2 -2,-0.2 0.957 114.6 47.7 -69.4 -51.6 59.3 25.0 -5.8 219 222 A A H < S+ 0 0 63 -4,-2.9 -2,-0.2 1,-0.2 -3,-0.2 0.894 117.7 42.1 -56.7 -44.8 61.4 23.7 -8.7 220 223 A I H < S+ 0 0 97 -4,-2.6 -1,-0.2 -5,-0.2 -2,-0.2 0.854 122.5 37.0 -74.2 -36.4 64.0 22.1 -6.5 221 224 A N H < S- 0 0 16 -4,-1.8 -2,-0.2 -5,-0.3 -3,-0.2 0.742 83.3-155.2 -89.5 -25.2 61.7 20.7 -3.9 222 225 A Q < - 0 0 129 -4,-2.9 -3,-0.1 -5,-0.2 -4,-0.1 0.935 17.2-158.6 49.8 56.5 58.9 19.6 -6.1 223 226 A P - 0 0 11 0, 0.0 -1,-0.1 0, 0.0 8,-0.1 -0.395 16.6-120.9 -68.2 141.9 56.2 19.7 -3.3 224 227 A N > - 0 0 80 3,-0.2 3,-2.0 1,-0.1 7,-0.4 -0.764 15.7-155.0 -86.6 113.5 53.1 17.6 -3.9 225 228 A P T 3 S+ 0 0 63 0, 0.0 -1,-0.1 0, 0.0 3,-0.1 0.656 92.9 58.8 -60.2 -19.9 50.1 20.0 -3.8 226 229 A R T 3 S+ 0 0 70 1,-0.2 2,-0.4 2,-0.0 -2,-0.0 0.329 98.8 65.4 -94.6 8.5 47.8 17.1 -2.8 227 230 A D X> - 0 0 41 -3,-2.0 4,-2.0 1,-0.1 3,-0.6 -0.794 61.4-173.4-132.8 90.0 49.8 16.5 0.3 228 231 A G H 3> S+ 0 0 1 -2,-0.4 4,-2.7 1,-0.3 5,-0.2 0.874 88.7 51.2 -49.4 -45.5 49.7 19.4 2.8 229 232 A I H 3> S+ 0 0 10 1,-0.2 4,-2.3 2,-0.2 -1,-0.3 0.877 108.1 53.0 -62.8 -36.2 52.3 17.9 5.0 230 233 A D H <> S+ 0 0 24 -3,-0.6 4,-1.5 2,-0.2 -1,-0.2 0.890 111.3 46.7 -66.0 -37.7 54.6 17.4 2.1 231 234 A V H X S+ 0 0 0 -4,-2.0 4,-2.1 -7,-0.4 5,-0.5 0.944 112.1 49.3 -68.2 -49.1 54.3 21.0 1.2 232 235 A L H X S+ 0 0 0 -4,-2.7 4,-1.0 1,-0.2 -2,-0.2 0.907 112.9 46.6 -56.9 -46.7 54.8 22.3 4.7 233 236 A S H < S+ 0 0 5 -4,-2.3 -93,-2.0 -5,-0.2 -94,-0.8 0.835 120.2 38.8 -68.7 -31.6 58.0 20.2 5.2 234 237 A K H < S+ 0 0 49 -4,-1.5 -95,-1.1 -96,-0.2 -2,-0.2 0.970 136.2 7.3 -84.5 -61.1 59.5 21.2 1.9 235 238 A V H < S+ 0 0 0 -4,-2.1 -52,-0.3 -5,-0.2 -53,-0.2 0.158 116.0 80.6-110.6 17.7 58.8 24.8 1.2 236 239 A G < - 0 0 0 -4,-1.0 2,-0.3 -5,-0.5 -102,-0.2 0.125 67.7-127.5 -98.1-145.7 57.2 25.7 4.6 237 240 A G > - 0 0 0 1,-0.1 4,-2.4 -58,-0.1 5,-0.2 -0.973 27.6 -99.3-162.7 166.1 58.7 26.6 8.0 238 241 A F H > S+ 0 0 3 -172,-0.3 4,-2.6 -2,-0.3 5,-0.1 0.885 122.0 48.9 -60.3 -42.3 58.5 25.7 11.7 239 242 A D H > S+ 0 0 0 2,-0.2 4,-2.3 1,-0.2 -1,-0.2 0.898 111.6 48.7 -65.5 -42.2 56.2 28.6 12.4 240 243 A L H > S+ 0 0 0 2,-0.2 4,-1.8 1,-0.2 -2,-0.2 0.890 111.7 49.9 -65.6 -39.0 53.9 27.8 9.5 241 244 A V H X S+ 0 0 0 -4,-2.4 4,-2.0 1,-0.2 -2,-0.2 0.946 109.4 52.5 -62.8 -46.8 53.8 24.2 10.6 242 245 A G H X S+ 0 0 0 -4,-2.6 4,-1.7 1,-0.2 -2,-0.2 0.894 107.1 50.2 -56.5 -45.7 52.9 25.3 14.2 243 246 A M H X S+ 0 0 0 -4,-2.3 4,-1.8 1,-0.2 -1,-0.2 0.885 109.3 52.9 -60.7 -38.0 50.0 27.4 13.1 244 247 A T H X S+ 0 0 0 -4,-1.8 4,-1.8 1,-0.2 -1,-0.2 0.885 107.3 53.4 -64.1 -36.6 48.7 24.5 11.1 245 248 A G H X S+ 0 0 0 -4,-2.0 4,-2.3 2,-0.2 -1,-0.2 0.829 104.2 53.3 -68.2 -33.5 49.0 22.4 14.3 246 249 A V H X S+ 0 0 0 -4,-1.7 4,-2.8 1,-0.2 5,-0.2 0.925 108.9 51.1 -66.8 -40.4 46.9 24.9 16.3 247 250 A M H X S+ 0 0 0 -4,-1.8 4,-1.7 1,-0.2 -2,-0.2 0.879 112.5 44.5 -63.4 -39.7 44.2 24.6 13.7 248 251 A L H X S+ 0 0 0 -4,-1.8 4,-2.6 2,-0.2 -1,-0.2 0.888 113.6 51.4 -72.9 -38.8 44.1 20.8 13.8 249 252 A G H X S+ 0 0 1 -4,-2.3 4,-1.9 2,-0.2 -2,-0.2 0.941 111.5 45.5 -63.3 -47.8 44.2 20.8 17.5 250 253 A A H <>S+ 0 0 0 -4,-2.8 5,-3.3 2,-0.2 -1,-0.2 0.895 112.8 51.4 -64.8 -38.2 41.3 23.2 17.9 251 254 A A H ><5S+ 0 0 0 -4,-1.7 3,-1.9 -5,-0.2 -2,-0.2 0.953 109.7 48.6 -62.6 -49.1 39.3 21.3 15.3 252 255 A R H 3<5S+ 0 0 91 -4,-2.6 -1,-0.2 1,-0.3 -2,-0.2 0.859 112.7 50.2 -56.4 -36.1 39.9 18.0 17.1 253 256 A a T 3<5S- 0 0 28 -4,-1.9 -1,-0.3 -5,-0.2 -2,-0.2 0.439 115.5-122.1 -80.2 -4.2 38.8 19.8 20.2 254 257 A G T < 5 + 0 0 1 -3,-1.9 -206,-1.9 1,-0.2 -205,-0.4 0.839 67.4 132.3 64.6 35.3 35.7 21.1 18.4 255 258 A L < - 0 0 7 -5,-3.3 -1,-0.2 -207,-0.2 -2,-0.1 -0.868 58.3-102.5-122.1 154.9 36.6 24.7 19.0 256 259 A P - 0 0 2 0, 0.0 -89,-1.9 0, 0.0 2,-0.4 -0.401 27.8-161.0 -74.1 144.9 36.8 27.9 16.9 257 260 A V E -ef 167 282B 0 24,-2.5 26,-2.3 -91,-0.2 2,-0.5 -0.995 9.3-144.9-129.8 128.3 40.0 29.3 15.6 258 261 A L E -ef 168 283B 0 -91,-2.8 -89,-1.8 -2,-0.4 60,-0.1 -0.803 17.4-143.8 -92.2 126.6 40.5 32.9 14.4 259 262 A L - 0 0 1 24,-2.7 27,-0.1 -2,-0.5 -89,-0.0 -0.289 11.4-161.1 -78.1 172.4 43.0 33.3 11.6 260 263 A D - 0 0 1 1,-0.4 26,-0.5 25,-0.1 25,-0.4 0.253 41.5 -37.0-120.7-109.9 45.3 36.3 11.4 261 264 A G S > S- 0 0 8 26,-0.1 4,-1.9 24,-0.1 3,-0.4 -0.001 83.2 -48.8-104.8-151.9 47.0 37.5 8.2 262 265 A F H > S+ 0 0 5 1,-0.2 4,-1.7 2,-0.2 5,-0.2 0.861 130.1 51.7 -50.8 -47.5 48.8 36.2 5.1 263 266 A L H > S+ 0 0 13 1,-0.2 4,-1.5 2,-0.2 -1,-0.2 0.885 110.4 50.0 -60.6 -38.6 51.0 33.7 7.0 264 267 A S H > S+ 0 0 0 -3,-0.4 4,-2.1 1,-0.2 -1,-0.2 0.849 104.7 58.8 -68.8 -34.5 48.0 32.3 8.7 265 268 A Y H X S+ 0 0 1 -4,-1.9 4,-1.9 1,-0.2 -1,-0.2 0.899 105.7 48.1 -61.5 -42.8 46.2 31.9 5.3 266 269 A S H X S+ 0 0 0 -4,-1.7 4,-2.0 2,-0.2 -1,-0.2 0.891 111.6 49.6 -66.4 -37.8 48.9 29.6 4.0 267 270 A A H X S+ 0 0 0 -4,-1.5 4,-2.6 1,-0.2 -1,-0.2 0.849 110.2 52.1 -67.6 -33.1 48.8 27.5 7.1 268 271 A A H X S+ 0 0 0 -4,-2.1 4,-2.5 2,-0.2 -2,-0.2 0.849 106.4 53.2 -70.2 -36.0 45.1 27.3 6.8 269 272 A L H X S+ 0 0 16 -4,-1.9 4,-1.5 2,-0.2 -2,-0.2 0.931 111.6 46.1 -63.6 -43.9 45.5 26.1 3.2 270 273 A A H X S+ 0 0 0 -4,-2.0 4,-2.5 2,-0.2 3,-0.4 0.956 112.3 50.7 -62.6 -51.0 47.8 23.4 4.4 271 274 A A H X S+ 0 0 0 -4,-2.6 4,-2.8 1,-0.2 7,-0.2 0.891 110.9 47.3 -55.0 -45.6 45.4 22.4 7.2 272 275 A C H < S+ 0 0 25 -4,-2.5 -1,-0.2 1,-0.2 -2,-0.2 0.791 111.7 52.0 -68.9 -26.3 42.4 22.2 5.0 273 276 A Q H < S+ 0 0 88 -4,-1.5 -2,-0.2 -3,-0.4 -1,-0.2 0.889 113.3 44.0 -74.7 -38.9 44.4 20.1 2.5 274 277 A I H < S+ 0 0 32 -4,-2.5 -2,-0.2 1,-0.3 -3,-0.2 0.903 137.4 6.1 -71.1 -43.7 45.5 17.7 5.3 275 278 A A >< - 0 0 7 -4,-2.8 3,-2.0 -5,-0.2 -1,-0.3 -0.810 59.0-167.9-147.1 99.6 42.0 17.5 6.8 276 279 A P G > S+ 0 0 95 0, 0.0 3,-1.7 0, 0.0 -1,-0.1 0.799 84.4 76.7 -55.5 -30.4 39.0 19.2 5.1 277 280 A A G 3 S+ 0 0 49 1,-0.3 4,-0.1 2,-0.1 -5,-0.1 0.542 82.7 69.5 -60.1 -5.6 37.0 18.6 8.3 278 281 A V G X S+ 0 0 0 -3,-2.0 3,-2.0 -7,-0.2 4,-0.5 0.802 75.4 82.3 -83.7 -29.4 38.9 21.5 9.8 279 282 A R G X S+ 0 0 75 -3,-1.7 3,-1.5 -4,-0.3 -1,-0.2 0.800 82.2 60.0 -42.9 -47.3 37.3 24.2 7.6 280 283 A P G 3 S+ 0 0 47 0, 0.0 -1,-0.3 0, 0.0 -2,-0.1 0.694 103.5 53.4 -59.5 -20.6 34.1 24.6 9.7 281 284 A Y G < S+ 0 0 1 -3,-2.0 -24,-2.5 -4,-0.1 2,-0.3 0.553 88.3 99.5 -92.4 -9.8 36.2 25.6 12.7 282 285 A L E < -f 257 0B 0 -3,-1.5 -24,-0.2 -4,-0.5 -35,-0.0 -0.593 48.7-174.0 -84.2 137.0 38.0 28.4 10.9 283 286 A I E -f 258 0B 0 -26,-2.3 -24,-2.7 -2,-0.3 19,-0.0 -0.992 18.8-134.7-130.7 124.2 37.0 32.0 11.3 284 287 A P - 0 0 9 0, 0.0 3,-0.1 0, 0.0 21,-0.1 -0.361 20.6-179.1 -73.8 157.3 38.6 34.9 9.3 285 288 A S - 0 0 1 1,-0.5 21,-2.6 -25,-0.4 20,-1.2 0.573 54.8 -4.3-117.8 -79.1 39.6 38.1 11.0 286 289 A H B -h 306 0D 4 -26,-0.5 2,-0.8 19,-0.2 -1,-0.5 -0.702 63.5-110.3-118.7 169.2 41.1 40.8 8.8 287 290 A F - 0 0 66 19,-2.1 22,-0.5 -2,-0.2 21,-0.3 -0.860 39.6-136.2-101.7 101.1 42.2 41.2 5.2 288 291 A S - 0 0 6 -2,-0.8 23,-0.2 -28,-0.2 5,-0.1 -0.219 7.2-132.5 -57.1 144.8 46.0 41.3 5.1 289 292 A A + 0 0 50 21,-1.9 -1,-0.1 4,-0.1 22,-0.1 0.426 69.2 122.1 -79.7 0.1 47.6 44.0 2.9 290 293 A E S > S- 0 0 13 20,-0.3 3,-2.1 1,-0.1 4,-0.3 -0.441 72.9-121.9 -65.6 137.4 50.0 41.3 1.5 291 294 A K T > S+ 0 0 134 1,-0.3 3,-0.5 2,-0.1 4,-0.3 0.832 108.7 48.7 -47.8 -46.0 49.7 41.0 -2.3 292 295 A G T 3> S+ 0 0 0 -97,-0.6 4,-2.2 1,-0.2 -1,-0.3 0.401 83.2 98.6 -81.0 5.4 48.8 37.3 -2.3 293 296 A A H <> S+ 0 0 0 -3,-2.1 4,-2.7 1,-0.2 5,-0.2 0.902 78.9 51.7 -58.5 -46.8 46.0 37.7 0.3 294 297 A R H <> S+ 0 0 56 -3,-0.5 4,-2.0 -4,-0.3 -1,-0.2 0.921 112.1 45.9 -57.6 -48.5 43.1 37.9 -2.1 295 298 A I H > S+ 0 0 43 -4,-0.3 4,-1.8 2,-0.2 -1,-0.2 0.929 113.4 48.7 -61.5 -48.4 44.1 34.7 -3.9 296 299 A A H X S+ 0 0 0 -4,-2.2 4,-1.0 1,-0.2 -2,-0.2 0.936 112.7 48.3 -58.6 -47.8 44.7 32.8 -0.7 297 300 A L H <>S+ 0 0 5 -4,-2.7 5,-2.7 1,-0.2 4,-0.5 0.839 107.6 55.5 -62.4 -36.0 41.4 33.9 0.8 298 301 A A H ><5S+ 0 0 68 -4,-2.0 3,-0.6 1,-0.2 -1,-0.2 0.906 107.3 48.2 -65.6 -41.0 39.5 33.0 -2.4 299 302 A H H 3<5S+ 0 0 108 -4,-1.8 -1,-0.2 1,-0.3 -2,-0.2 0.723 113.1 48.4 -72.0 -19.4 40.7 29.4 -2.4 300 303 A L T 3<5S- 0 0 9 -4,-1.0 -1,-0.3 -5,-0.2 -2,-0.2 0.517 109.3-133.0 -91.4 -10.4 39.8 29.2 1.3 301 304 A S T < 5 + 0 0 102 -3,-0.6 2,-0.3 -4,-0.5 -3,-0.2 0.899 56.7 143.6 58.1 43.3 36.5 30.7 0.2 302 305 A M < - 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0 0 66 -4,-1.5 2,-0.1 -5,-0.4 -4,-0.0 -0.367 68.0-120.7 -73.2 153.1 18.5 40.4 22.7 336 339 A G - 0 0 38 -309,-0.1 -309,-2.7 1,-0.1 2,-0.4 -0.248 28.7-109.4 -80.6 175.8 14.8 40.4 23.2 337 340 A E B >> -A 26 0A 94 -311,-0.3 4,-1.0 1,-0.1 3,-0.8 -0.898 6.8-132.8-117.1 142.4 12.2 38.6 21.1 338 341 A L G >4>S+ 0 0 21 -313,-2.2 5,-2.3 -2,-0.4 3,-0.9 0.895 106.0 56.7 -50.7 -50.4 9.6 39.9 18.6 339 342 A A G >45S+ 0 0 82 -314,-0.4 3,-0.9 1,-0.3 -1,-0.2 0.820 102.1 57.7 -54.8 -33.9 6.8 37.7 20.0 340 343 A A G <45S+ 0 0 76 -3,-0.8 -1,-0.3 1,-0.2 -2,-0.2 0.839 109.6 42.6 -68.4 -33.5 7.3 39.2 23.4 341 344 A S G <<5S- 0 0 68 -4,-1.0 -1,-0.2 -3,-0.9 -2,-0.2 0.320 114.3-117.1 -93.7 7.6 6.7 42.8 22.1 342 345 A N T < 5 + 0 0 140 -3,-0.9 2,-0.5 -4,-0.4 -3,-0.2 0.873 62.4 153.8 60.5 36.7 3.8 41.6 20.0 343 346 A I < - 0 0 71 -5,-2.3 2,-0.5 -6,-0.1 -1,-0.2 -0.867 25.6-168.8-101.1 129.9 5.7 42.6 16.9 344 347 A V + 0 0 138 -2,-0.5 -5,-0.0 -3,-0.1 0, 0.0 -0.944 9.0 175.3-122.6 111.8 4.8 40.7 13.6 345 348 A L 0 0 80 -2,-0.5 -2,-0.0 -317,-0.1 -317,-0.0 -0.884 360.0 360.0-115.1 145.6 7.0 41.2 10.6 346 349 A P 0 0 167 0, 0.0 -1,-0.0 0, 0.0 -2,-0.0 -0.243 360.0 360.0 -56.8 360.0 6.8 39.4 7.2