==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=7-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER BLOOD CLOTTING 16-JUN-02 1M10 . COMPND 2 MOLECULE: VON WILLEBRAND FACTOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR E.G.HUIZINGA,S.TSUJI,R.A.P.ROMIJN,M.E.SCHIPHORST,P.G.DE . 466 2 4 4 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 20591.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 316 67.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 69 14.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 26 5.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 1 0.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 44 9.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 60 12.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 65 13.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 4 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 2 2 0 1 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 3 0 10 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 2 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 505 A H 0 0 193 0, 0.0 3,-0.0 0, 0.0 34,-0.0 0.000 360.0 360.0 360.0 -23.0 -17.4 -38.9 6.5 2 506 A D - 0 0 129 1,-0.0 2,-0.2 0, 0.0 0, 0.0 0.866 360.0 -10.8 -40.5-107.3 -20.7 -37.7 5.1 3 507 A F S S- 0 0 76 2,-0.0 2,-0.3 36,-0.0 36,-0.0 -0.605 73.3-178.0 -94.1 163.4 -22.3 -35.0 7.2 4 508 A Y - 0 0 123 -2,-0.2 2,-0.2 2,-0.0 36,-0.1 -0.808 7.0-169.8-169.2 121.7 -20.8 -34.3 10.6 5 509 A a - 0 0 19 34,-0.3 2,-0.3 -2,-0.3 36,-0.2 -0.558 12.2-146.0-111.7 175.6 -21.6 -32.0 13.5 6 510 A S + 0 0 18 -2,-0.2 191,-1.0 34,-0.2 2,-0.2 -0.983 32.7 146.8-141.5 126.2 -20.0 -30.8 16.8 7 511 A R B -A 196 0A 61 -2,-0.3 2,-1.3 189,-0.2 189,-0.2 -0.792 57.0 -70.4-148.4-174.3 -22.0 -30.0 20.0 8 512 A L S S+ 0 0 13 187,-2.4 103,-1.7 -2,-0.2 2,-0.4 -0.756 74.2 154.6 -84.4 97.8 -22.4 -29.8 23.8 9 513 A L E -bc 47 111B 4 37,-2.3 39,-2.5 -2,-1.3 2,-0.5 -0.974 45.8-167.3-139.7 145.2 -22.7 -33.5 24.3 10 514 A D E -bc 48 112B 5 101,-1.1 103,-2.0 -2,-0.4 2,-0.5 -0.875 28.9-175.4-125.6 91.2 -22.1 -36.2 26.9 11 515 A L E -bc 49 113B 1 37,-2.1 39,-1.1 -2,-0.5 2,-0.5 -0.822 9.6-163.7 -99.5 123.5 -22.3 -39.4 24.9 12 516 A V E -bc 50 114B 0 101,-2.7 103,-2.0 -2,-0.5 2,-0.4 -0.878 6.5-152.0-106.9 131.7 -22.2 -42.8 26.5 13 517 A F E -bc 51 115B 0 37,-3.2 39,-1.9 -2,-0.5 2,-0.5 -0.864 10.0-174.2-103.0 133.0 -21.5 -45.9 24.5 14 518 A L E -bc 52 116B 0 101,-1.4 103,-2.4 -2,-0.4 2,-0.5 -0.916 9.5-166.0-128.8 103.2 -22.9 -49.2 25.8 15 519 A L E -bc 53 117B 1 37,-2.6 39,-2.2 -2,-0.5 2,-0.4 -0.795 23.4-121.9 -98.0 128.9 -21.8 -52.2 23.7 16 520 A D E -b 54 0B 1 101,-0.9 39,-0.1 -2,-0.5 67,-0.1 -0.496 24.7-171.5 -65.0 119.9 -23.4 -55.6 24.0 17 521 A G + 0 0 0 37,-1.5 68,-1.3 -2,-0.4 2,-0.2 -0.245 42.8 118.2-108.7 44.4 -20.7 -58.0 25.0 18 522 A S B > S-j 85 0C 1 66,-0.2 3,-0.6 65,-0.1 66,-0.4 -0.571 78.2-108.6-102.1 171.7 -22.7 -61.2 24.6 19 523 A S T 3 S+ 0 0 61 66,-2.5 67,-0.1 65,-0.4 66,-0.1 0.633 100.2 94.1 -74.5 -14.7 -22.0 -64.1 22.2 20 524 A R T 3 S+ 0 0 132 65,-0.3 2,-0.3 1,-0.1 -1,-0.3 0.402 88.7 56.0 -59.2 8.1 -25.0 -63.1 20.1 21 525 A L S < S- 0 0 7 -3,-0.6 5,-0.1 129,-0.0 -1,-0.1 -0.961 91.8-128.7-142.2 119.3 -22.2 -61.2 18.2 22 526 A S > - 0 0 46 -2,-0.3 4,-1.8 1,-0.1 5,-0.1 -0.178 26.9-111.9 -62.9 164.4 -19.2 -63.1 16.9 23 527 A E H >> S+ 0 0 121 1,-0.2 4,-1.9 2,-0.2 3,-0.6 0.956 125.7 52.7 -60.5 -46.5 -15.8 -61.7 17.8 24 528 A A H 3> S+ 0 0 70 1,-0.3 4,-0.8 2,-0.2 -1,-0.2 0.857 111.3 46.4 -54.2 -37.5 -15.5 -60.9 14.1 25 529 A E H 3> S+ 0 0 68 2,-0.2 4,-0.6 1,-0.2 -1,-0.3 0.696 103.5 62.3 -79.9 -21.0 -18.9 -59.1 14.5 26 530 A F H XX S+ 0 0 1 -4,-1.8 4,-2.7 -3,-0.6 3,-1.3 0.925 99.5 56.1 -67.7 -42.3 -17.8 -57.3 17.7 27 531 A E H 3X S+ 0 0 80 -4,-1.9 4,-3.1 1,-0.3 -1,-0.2 0.851 102.1 55.2 -54.6 -40.5 -15.1 -55.6 15.6 28 532 A V H 3X S+ 0 0 53 -4,-0.8 4,-1.3 2,-0.2 -1,-0.3 0.684 109.7 47.4 -69.2 -18.9 -17.7 -54.2 13.3 29 533 A L H < S+ 0 0 4 -4,-2.6 3,-1.5 1,-0.2 -1,-0.3 0.939 105.7 54.0 -69.1 -49.2 -16.3 -40.6 17.6 38 542 A E H 3< S+ 0 0 94 -4,-2.1 2,-0.9 1,-0.3 -2,-0.2 0.927 99.6 62.2 -52.4 -49.0 -14.4 -39.2 14.6 39 543 A Q T 3< S+ 0 0 8 -4,-2.5 -34,-0.3 -5,-0.1 -1,-0.3 0.147 104.1 67.1 -66.5 27.5 -17.5 -37.4 13.5 40 544 A L S < S- 0 0 8 -3,-1.5 2,-0.7 -2,-0.9 -34,-0.2 -0.920 90.3-110.4-157.0 126.9 -17.2 -35.5 16.8 41 545 A R - 0 0 78 -2,-0.3 6,-0.8 -36,-0.2 2,-0.6 -0.300 42.5-147.3 -51.0 98.5 -14.8 -33.0 18.5 42 546 A I B +d 47 0B 17 -2,-0.7 2,-0.3 -4,-0.1 6,-0.2 -0.601 45.8 105.6 -81.0 118.2 -13.4 -35.3 21.1 43 547 A S B >> S-E 47 0B 41 4,-2.1 3,-0.9 -2,-0.6 4,-0.6 -0.926 78.8-108.8-179.0 155.9 -12.5 -33.5 24.3 44 548 A Q T 34 S+ 0 0 44 -2,-0.3 4,-0.2 1,-0.2 -2,-0.1 0.359 117.6 63.8 -75.7 11.1 -13.6 -33.0 27.9 45 549 A K T 34 S+ 0 0 65 2,-0.2 -1,-0.2 -4,-0.1 3,-0.1 0.691 120.2 0.9-108.1 -23.9 -14.5 -29.6 26.5 46 550 A W T <4 S+ 0 0 34 -3,-0.9 -37,-2.3 1,-0.3 2,-0.5 0.653 132.7 16.6-127.7 -54.1 -17.2 -30.2 23.9 47 551 A V E < -bE 9 43B 0 -6,-0.8 -4,-2.1 -4,-0.6 -1,-0.3 -0.977 66.3-171.0-132.2 112.4 -18.1 -33.7 23.5 48 552 A R E -b 10 0B 15 -39,-2.5 -37,-2.1 -2,-0.5 2,-0.3 -0.674 11.7-174.4 -99.4 160.2 -17.2 -36.1 26.2 49 553 A V E -b 11 0B 7 14,-0.3 2,-0.3 -2,-0.3 17,-0.3 -0.946 17.5-162.6-149.8 170.2 -17.6 -39.8 25.8 50 554 A A E -b 12 0B 2 -39,-1.1 -37,-3.2 -2,-0.3 2,-0.5 -0.974 9.4-151.3-156.3 142.4 -17.4 -43.2 27.5 51 555 A V E +b 13 0B 0 11,-0.4 10,-2.9 -2,-0.3 11,-1.3 -0.980 18.5 173.3-123.5 122.7 -17.3 -46.7 26.3 52 556 A V E -bF 14 60B 1 -39,-1.9 -37,-2.6 -2,-0.5 2,-0.4 -0.994 14.4-161.9-131.3 124.4 -18.6 -49.5 28.4 53 557 A E E -bF 15 59B 4 6,-1.7 6,-1.2 -2,-0.4 2,-0.2 -0.882 25.0-168.4-104.5 137.2 -19.0 -53.1 27.2 54 558 A Y E +bF 16 58B 1 -39,-2.2 -37,-1.5 -2,-0.4 4,-0.2 -0.739 40.1 118.7-127.7 175.8 -21.3 -55.2 29.3 55 559 A H S S+ 0 0 18 2,-0.8 34,-1.8 -2,-0.2 2,-1.0 -0.649 94.0 19.4 171.0 -99.0 -22.7 -58.6 30.2 56 560 A D S S- 0 0 79 31,-0.2 32,-0.0 32,-0.2 29,-0.0 -0.826 137.7 -27.6 -91.9 106.3 -22.2 -59.5 33.9 57 561 A G S S- 0 0 2 -2,-1.0 -2,-0.8 383,-0.1 383,-0.3 0.137 94.7 -68.2 70.7 163.8 -21.5 -56.0 35.3 58 562 A S E -FG 54 439B 2 381,-1.5 381,-1.3 -4,-0.2 2,-0.4 -0.492 29.9-150.9 -92.3 159.7 -20.0 -53.2 33.3 59 563 A H E -FG 53 438B 36 -6,-1.2 -6,-1.7 379,-0.2 2,-0.4 -0.792 15.5-157.9-133.0 89.3 -16.6 -52.8 31.9 60 564 A A E +FG 52 437B 16 377,-1.9 377,-2.3 -2,-0.4 -8,-0.2 -0.527 24.0 163.0 -69.9 120.5 -15.6 -49.1 31.7 61 565 A Y S S+ 0 0 25 -10,-2.9 2,-0.3 1,-0.4 -1,-0.2 0.730 70.7 21.9-106.4 -36.1 -12.9 -48.4 29.2 62 566 A I - 0 0 6 -11,-1.3 -11,-0.4 375,-0.1 -1,-0.4 -0.949 67.6-158.4-131.8 152.3 -13.4 -44.7 28.9 63 567 A G > - 0 0 21 -2,-0.3 3,-1.7 -13,-0.2 -14,-0.3 -0.951 30.6-115.4-131.1 151.9 -15.0 -42.1 31.1 64 568 A L T 3 S+ 0 0 24 -2,-0.3 -15,-0.2 1,-0.3 -1,-0.1 0.881 118.7 42.3 -52.5 -41.0 -16.4 -38.7 30.5 65 569 A K T 3 S+ 0 0 120 -17,-0.1 2,-0.3 2,-0.1 -1,-0.3 0.514 83.7 123.9 -85.9 -3.5 -13.8 -37.1 32.7 66 570 A D < - 0 0 65 -3,-1.7 2,-0.9 -17,-0.3 -17,-0.1 -0.420 55.2-145.8 -61.6 118.0 -11.0 -39.2 31.3 67 571 A R + 0 0 111 -2,-0.3 2,-0.3 -24,-0.1 -1,-0.1 -0.775 44.8 126.8 -94.5 105.1 -8.3 -36.8 29.9 68 572 A K - 0 0 79 -2,-0.9 5,-0.1 3,-0.0 -24,-0.1 -0.974 63.1 -94.5-154.8 139.7 -6.7 -38.3 26.9 69 573 A R > - 0 0 166 -2,-0.3 4,-2.1 1,-0.1 3,-0.3 -0.220 39.1-111.0 -56.6 145.4 -6.2 -37.0 23.4 70 574 A P H > S+ 0 0 49 0, 0.0 4,-1.7 0, 0.0 5,-0.3 0.872 119.9 56.5 -44.0 -47.3 -8.8 -38.0 20.8 71 575 A S H > S+ 0 0 50 1,-0.2 4,-1.8 2,-0.2 -2,-0.0 0.964 108.0 48.6 -50.7 -53.4 -6.2 -40.1 19.0 72 576 A E H > S+ 0 0 41 -3,-0.3 4,-2.0 2,-0.2 -1,-0.2 0.907 111.7 48.6 -53.3 -51.0 -5.7 -42.0 22.3 73 577 A L H X S+ 0 0 8 -4,-2.1 4,-2.2 1,-0.2 5,-0.4 0.977 106.4 53.2 -53.1 -77.4 -9.4 -42.5 22.9 74 578 A R H X S+ 0 0 85 -4,-1.7 4,-1.7 1,-0.2 -1,-0.2 0.747 111.4 51.4 -27.1 -44.0 -10.4 -43.8 19.5 75 579 A R H >X S+ 0 0 78 -4,-1.8 3,-2.1 -5,-0.3 4,-1.3 0.993 110.6 43.2 -60.4 -75.1 -7.6 -46.3 19.9 76 580 A I H >< S+ 0 0 3 -4,-2.0 3,-1.1 1,-0.3 4,-0.3 0.847 111.1 57.2 -35.3 -51.5 -8.6 -47.7 23.4 77 581 A A H >< S+ 0 0 3 -4,-2.2 3,-1.0 1,-0.3 -1,-0.3 0.898 109.5 46.1 -50.8 -41.9 -12.2 -47.7 22.2 78 582 A S H << S+ 0 0 49 -3,-2.1 -1,-0.3 -4,-1.7 -2,-0.2 0.688 104.6 60.3 -76.3 -19.9 -11.1 -50.0 19.4 79 583 A Q T << S+ 0 0 104 -4,-1.3 2,-0.5 -3,-1.1 -1,-0.2 0.273 71.3 139.6 -91.7 13.8 -9.0 -52.2 21.6 80 584 A V < - 0 0 0 -3,-1.0 2,-0.1 -4,-0.3 -50,-0.1 -0.445 57.5-120.1 -61.8 112.6 -12.1 -53.2 23.7 81 585 A K - 0 0 154 -2,-0.5 -1,-0.1 1,-0.1 -2,-0.1 -0.332 23.6-111.5 -62.2 126.0 -11.7 -56.9 24.4 82 586 A Y - 0 0 64 1,-0.1 -1,-0.1 -2,-0.1 -65,-0.1 -0.240 31.8-176.8 -54.7 138.0 -14.4 -59.2 23.1 83 587 A A - 0 0 36 -65,-0.2 -1,-0.1 -67,-0.1 -65,-0.1 0.819 3.2-178.5-104.7 -53.2 -16.4 -60.7 25.9 84 588 A G + 0 0 16 -66,-0.4 -65,-0.4 1,-0.1 -66,-0.2 0.625 24.2 162.5 61.8 13.9 -18.8 -63.1 24.1 85 589 A S B -j 18 0C 27 -68,-1.3 -66,-2.5 -67,-0.2 -65,-0.3 0.034 48.5-118.3 -55.7 173.1 -20.4 -64.0 27.4 86 590 A Q S S+ 0 0 183 -68,-0.2 2,-0.3 -67,-0.1 -1,-0.1 0.793 93.6 45.0 -86.6 -29.2 -23.9 -65.7 27.5 87 591 A V + 0 0 40 -70,-0.1 -31,-0.2 35,-0.1 2,-0.2 -0.860 51.7 178.2-117.4 150.9 -25.6 -62.9 29.4 88 592 A A - 0 0 1 -2,-0.3 2,-0.6 -33,-0.2 -32,-0.2 -0.716 23.9-145.9-150.6 88.4 -25.6 -59.1 29.1 89 593 A S > - 0 0 1 -34,-1.8 4,-2.0 -2,-0.2 -34,-0.2 -0.446 14.7-174.2 -64.5 110.7 -27.9 -57.5 31.6 90 594 A T H > S+ 0 0 1 -2,-0.6 4,-1.6 1,-0.2 5,-0.2 0.893 89.9 56.4 -69.9 -36.3 -29.3 -54.4 30.0 91 595 A S H > S+ 0 0 3 1,-0.2 4,-1.5 2,-0.2 -1,-0.2 0.874 107.0 50.7 -61.5 -36.3 -30.9 -53.6 33.3 92 596 A E H > S+ 0 0 26 2,-0.2 4,-3.0 1,-0.2 3,-0.3 0.966 107.2 48.5 -66.1 -56.0 -27.4 -53.8 34.9 93 597 A V H X S+ 0 0 0 -4,-2.0 4,-2.4 1,-0.3 -1,-0.2 0.787 115.0 48.1 -58.1 -27.4 -25.6 -51.4 32.5 94 598 A L H X S+ 0 0 0 -4,-1.6 4,-2.6 2,-0.2 -1,-0.3 0.816 109.7 50.5 -82.2 -30.8 -28.4 -48.9 33.0 95 599 A K H X S+ 0 0 4 -4,-1.5 4,-1.8 -3,-0.3 5,-0.3 0.894 114.4 48.0 -67.5 -39.8 -28.4 -49.3 36.8 96 600 A Y H X>S+ 0 0 32 -4,-3.0 4,-4.0 2,-0.2 5,-0.6 0.949 112.9 44.7 -64.1 -53.2 -24.7 -48.7 36.4 97 601 A T H X>S+ 0 0 0 -4,-2.4 5,-2.6 3,-0.2 4,-1.4 0.898 109.7 56.6 -61.4 -42.3 -25.0 -45.6 34.2 98 602 A L H <5S+ 0 0 15 -4,-2.6 -1,-0.2 1,-0.2 -2,-0.2 0.921 125.3 19.2 -57.5 -43.7 -27.8 -44.1 36.3 99 603 A F H <5S+ 0 0 35 -4,-1.8 -2,-0.2 -5,-0.2 -1,-0.2 0.744 132.2 37.6-102.5 -23.8 -25.6 -44.2 39.4 100 604 A Q H <5S+ 0 0 56 -4,-4.0 -3,-0.2 -5,-0.3 -2,-0.1 0.591 126.9 28.1-106.3 -8.8 -22.0 -44.4 38.3 101 605 A I T < S+ 0 0 23 1,-0.2 3,-0.8 4,-0.1 -1,-0.3 -0.758 72.3 174.4 -95.0 87.0 -22.2 -29.9 32.6 108 612 A P T 3 S+ 0 0 76 0, 0.0 -1,-0.2 0, 0.0 -2,-0.1 0.766 73.2 55.5 -64.8 -29.4 -25.9 -29.1 33.2 109 613 A E T 3 S+ 0 0 69 -3,-0.1 2,-0.1 2,-0.1 -101,-0.1 0.636 93.4 86.7 -81.5 -14.4 -26.4 -27.2 30.0 110 614 A A S < S- 0 0 10 -3,-0.8 -101,-0.2 1,-0.1 2,-0.2 -0.397 78.7-116.9 -84.0 161.9 -25.3 -30.1 27.8 111 615 A S E -c 9 0B 20 -103,-1.7 -101,-1.1 84,-0.1 2,-0.4 -0.506 23.8-146.8 -91.0 167.2 -27.4 -33.0 26.5 112 616 A R E -ch 10 142B 11 29,-0.5 31,-2.3 -103,-0.2 2,-0.4 -0.997 15.2-179.5-138.1 141.5 -26.8 -36.6 27.5 113 617 A I E -ch 11 143B 0 -103,-2.0 -101,-2.7 -2,-0.4 2,-0.6 -0.999 18.4-156.9-143.5 141.0 -27.4 -39.7 25.6 114 618 A A E -ch 12 144B 0 29,-2.6 31,-0.8 -2,-0.4 2,-0.6 -0.846 15.2-156.1-119.1 89.0 -26.9 -43.3 26.4 115 619 A L E -ch 13 145B 0 -103,-2.0 -101,-1.4 -2,-0.6 2,-0.8 -0.577 13.1-159.7 -66.3 115.3 -26.5 -45.1 23.1 116 620 A L E -ch 14 146B 0 29,-1.1 31,-2.6 -2,-0.6 2,-1.2 -0.810 6.8-162.6-107.3 94.9 -27.5 -48.6 24.0 117 621 A L E -c 15 0B 0 -103,-2.4 -101,-0.9 -2,-0.8 2,-0.4 -0.606 16.1-177.8 -78.8 96.0 -26.2 -51.2 21.6 118 622 A M + 0 0 0 -2,-1.2 31,-1.0 29,-0.3 35,-0.1 -0.791 22.6 156.9 -97.8 136.3 -28.4 -54.3 22.3 119 623 A A + 0 0 2 -2,-0.4 33,-0.4 29,-0.2 2,-0.2 0.449 66.5 30.3-130.5 -12.0 -27.8 -57.5 20.4 120 624 A S S S- 0 0 5 -32,-0.1 34,-1.5 34,-0.1 2,-0.4 -0.596 78.4-102.5-133.0-167.2 -29.3 -60.0 22.9 121 625 A Q - 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