==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=7-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER SIGNALING PROTEIN 19-JUL-02 1M7E . COMPND 2 MOLECULE: DISABLED HOMOLOG 2; . SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; . AUTHOR M.YUN,L.KESHVARA,C.-G.PARK,Y.-M.ZHANG,J.B.DICKERSON,J.ZHENG, . 477 6 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 24557.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 378 79.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 144 30.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 3 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 3 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 44 9.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 36 7.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 142 29.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 3 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 2 1 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 3 0 3 3 6 3 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 32 A M 0 0 252 0, 0.0 2,-0.4 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 -95.9 -3.0 72.3 -10.0 2 33 A E - 0 0 151 2,-0.0 2,-1.6 0, 0.0 5,-0.1 -0.965 360.0-137.6-138.0 120.2 -2.9 68.5 -10.3 3 34 A K - 0 0 101 -2,-0.4 2,-0.0 4,-0.1 0, 0.0 -0.594 33.8-168.6 -79.2 89.5 0.2 66.5 -10.9 4 35 A T > - 0 0 47 -2,-1.6 4,-3.0 1,-0.1 5,-0.3 -0.290 37.2-104.2 -75.3 160.3 -1.2 64.0 -13.5 5 36 A D H > S+ 0 0 31 1,-0.2 4,-3.0 2,-0.2 5,-0.2 0.906 124.1 52.7 -52.6 -42.1 0.6 60.9 -14.6 6 37 A E H > S+ 0 0 126 2,-0.2 4,-2.5 1,-0.2 -1,-0.2 0.925 109.6 46.4 -60.5 -47.4 1.4 62.7 -17.8 7 38 A Y H > S+ 0 0 108 1,-0.2 4,-1.7 2,-0.2 -2,-0.2 0.958 115.0 47.8 -59.6 -49.4 2.9 65.7 -16.1 8 39 A L H X S+ 0 0 6 -4,-3.0 4,-2.3 1,-0.2 -2,-0.2 0.880 110.4 51.9 -59.6 -40.5 4.9 63.4 -13.8 9 40 A L H X S+ 0 0 55 -4,-3.0 4,-1.1 -5,-0.3 -1,-0.2 0.948 110.2 47.9 -62.0 -47.9 6.1 61.4 -16.8 10 41 A A H < S+ 0 0 79 -4,-2.5 -1,-0.2 1,-0.2 -2,-0.2 0.799 112.2 52.2 -63.1 -28.0 7.3 64.5 -18.6 11 42 A R H < S+ 0 0 73 -4,-1.7 -1,-0.2 -5,-0.2 -2,-0.2 0.901 117.7 33.0 -76.1 -43.4 9.0 65.6 -15.4 12 43 A F H < S+ 0 0 0 -4,-2.3 56,-2.5 4,-0.2 57,-0.3 0.379 92.1 115.9 -95.9 3.8 11.0 62.5 -14.7 13 44 A K S >< S- 0 0 146 -4,-1.1 3,-1.8 54,-0.2 2,-0.3 -0.488 84.7 -21.3 -73.9 140.7 11.6 61.5 -18.3 14 45 A G T 3 S+ 0 0 39 1,-0.3 55,-0.3 -2,-0.2 54,-0.2 -0.429 141.5 2.7 66.9-121.7 15.2 61.6 -19.5 15 46 A D T 3 S- 0 0 135 -2,-0.3 -1,-0.3 1,-0.2 51,-0.1 0.687 93.6-174.8 -72.9 -17.8 17.4 63.7 -17.4 16 47 A G < - 0 0 27 -3,-1.8 2,-0.2 -6,-0.1 51,-0.2 -0.211 40.7 -23.9 59.5-146.5 14.5 64.4 -15.1 17 48 A V E -A 66 0A 27 49,-2.2 49,-2.7 -5,-0.0 2,-0.4 -0.662 59.3-154.0-100.5 157.2 15.0 66.9 -12.2 18 49 A K E -A 65 0A 114 -2,-0.2 2,-0.4 47,-0.2 47,-0.2 -0.993 6.9-168.5-138.2 136.2 18.2 67.8 -10.6 19 50 A Y E -A 64 0A 45 45,-2.6 45,-3.3 -2,-0.4 2,-0.3 -0.966 21.4-127.8-127.9 142.2 19.1 69.2 -7.1 20 51 A K E +A 63 0A 102 -2,-0.4 101,-2.7 43,-0.2 102,-0.5 -0.652 51.1 129.9 -83.6 135.7 22.3 70.6 -5.6 21 52 A A E -AB 62 120A 1 41,-2.5 41,-3.2 -2,-0.3 2,-0.3 -0.928 48.3-106.5-164.9-171.9 23.4 68.9 -2.4 22 53 A K E -AB 61 119A 54 97,-2.6 97,-2.8 -2,-0.3 2,-0.9 -0.977 27.9-118.3-134.3 147.3 26.1 67.2 -0.3 23 54 A L E -AB 60 118A 19 37,-2.3 37,-0.6 -2,-0.3 95,-0.2 -0.757 24.1-175.4 -88.7 106.9 26.7 63.6 0.5 24 55 A I E - 0 0 13 93,-1.6 2,-0.3 -2,-0.9 -1,-0.2 0.905 56.4 -75.2 -67.2 -40.1 26.6 63.3 4.3 25 56 A G E - B 0 117A 15 92,-1.3 92,-2.5 -3,-0.1 2,-0.4 -0.943 34.2 -99.9 163.0 175.5 27.5 59.6 4.2 26 57 A I E - B 0 116A 62 -2,-0.3 2,-0.4 90,-0.2 90,-0.2 -0.980 31.0-177.7-128.0 139.2 26.7 56.0 3.5 27 58 A D E - B 0 115A 22 88,-1.7 88,-3.2 -2,-0.4 2,-0.3 -0.999 29.0-119.8-141.7 136.9 25.9 53.4 6.1 28 59 A D E - B 0 114A 124 -2,-0.4 86,-0.2 86,-0.2 84,-0.0 -0.577 37.1-163.2 -74.0 134.7 25.2 49.7 5.9 29 60 A V E - B 0 113A 14 84,-2.8 84,-0.6 -2,-0.3 82,-0.0 -0.942 24.5-136.6-125.8 145.8 21.7 49.0 7.3 30 61 A P S S+ 0 0 100 0, 0.0 2,-0.3 0, 0.0 81,-0.1 0.711 82.2 30.4 -71.6 -24.6 19.9 45.8 8.5 31 62 A D S S- 0 0 95 2,-0.1 -2,-0.0 1,-0.1 3,-0.0 -0.873 70.5-121.0-136.4 170.3 16.5 46.4 6.8 32 63 A A S S+ 0 0 4 -2,-0.3 2,-0.3 59,-0.1 74,-0.2 0.697 93.9 23.9 -80.1 -21.2 14.8 47.9 3.8 33 64 A R + 0 0 98 424,-0.1 4,-0.1 59,-0.0 59,-0.1 -0.859 64.0 118.3-139.3 171.4 12.5 50.2 5.8 34 65 A G > - 0 0 24 -2,-0.3 4,-2.3 3,-0.1 5,-0.2 0.130 39.8-145.1 131.3 117.3 12.2 52.0 9.1 35 66 A D H > S+ 0 0 28 2,-0.2 4,-2.5 1,-0.2 5,-0.2 0.951 107.6 43.3 -65.4 -50.4 12.0 55.5 10.5 36 67 A K H > S+ 0 0 32 2,-0.2 4,-2.8 1,-0.2 5,-0.2 0.929 114.7 49.8 -61.9 -47.3 14.0 54.6 13.7 37 68 A M H > S+ 0 0 28 1,-0.2 4,-1.8 2,-0.2 -1,-0.2 0.920 113.4 47.1 -58.4 -43.9 16.6 52.6 11.7 38 69 A S H X S+ 0 0 3 -4,-2.3 4,-2.5 2,-0.2 -1,-0.2 0.881 110.5 52.0 -66.3 -38.3 16.9 55.5 9.3 39 70 A Q H X S+ 0 0 20 -4,-2.5 4,-3.1 1,-0.2 5,-0.2 0.943 106.4 53.3 -64.2 -47.1 17.2 58.1 12.1 40 71 A D H X S+ 0 0 38 -4,-2.8 4,-2.4 1,-0.2 -1,-0.2 0.908 112.1 45.6 -54.4 -45.1 20.0 56.1 13.8 41 72 A S H X S+ 0 0 5 -4,-1.8 4,-3.2 2,-0.2 5,-0.3 0.955 112.3 49.4 -63.7 -51.0 22.0 56.1 10.6 42 73 A M H X S+ 0 0 4 -4,-2.5 4,-3.0 1,-0.2 5,-0.3 0.940 113.1 48.7 -53.2 -48.9 21.4 59.7 9.8 43 74 A M H X S+ 0 0 1 -4,-3.1 4,-1.9 2,-0.2 -1,-0.2 0.919 112.7 46.4 -59.1 -46.5 22.5 60.6 13.3 44 75 A K H X S+ 0 0 32 -4,-2.4 4,-2.4 -5,-0.2 -1,-0.2 0.932 115.1 47.5 -62.4 -45.3 25.6 58.4 13.2 45 76 A L H X S+ 0 0 6 -4,-3.2 4,-3.0 1,-0.2 -2,-0.2 0.892 111.7 48.8 -64.4 -40.4 26.6 59.8 9.8 46 77 A K H X S+ 0 0 44 -4,-3.0 4,-1.8 -5,-0.3 -1,-0.2 0.847 109.6 54.3 -69.3 -29.7 26.0 63.4 10.9 47 78 A G H X S+ 0 0 3 -4,-1.9 4,-2.0 -5,-0.3 -2,-0.2 0.946 111.6 44.1 -65.5 -45.9 28.1 62.7 13.9 48 79 A M H X S+ 0 0 81 -4,-2.4 4,-2.2 1,-0.2 -2,-0.2 0.927 111.1 52.3 -64.2 -46.2 30.9 61.5 11.7 49 80 A A H X S+ 0 0 24 -4,-3.0 4,-2.5 1,-0.2 -1,-0.2 0.860 108.7 53.3 -59.3 -34.4 30.6 64.4 9.2 50 81 A A H X S+ 0 0 56 -4,-1.8 4,-2.1 2,-0.2 -1,-0.2 0.928 106.0 50.5 -66.3 -46.8 30.8 66.8 12.1 51 82 A A H < S+ 0 0 22 -4,-2.0 -1,-0.2 1,-0.2 -2,-0.2 0.896 112.5 49.7 -58.2 -39.0 34.0 65.2 13.4 52 83 A G H ><>S+ 0 0 12 -4,-2.2 5,-2.3 1,-0.2 3,-2.0 0.930 106.9 53.4 -66.3 -44.0 35.4 65.6 9.9 53 84 A R H ><5S+ 0 0 142 -4,-2.5 3,-1.9 1,-0.3 -1,-0.2 0.856 99.3 62.0 -60.6 -34.5 34.3 69.2 9.7 54 85 A S T 3<5S+ 0 0 83 -4,-2.1 -1,-0.3 1,-0.3 -2,-0.2 0.549 107.5 47.7 -70.5 -1.8 36.2 70.1 12.9 55 86 A Q T < 5S- 0 0 147 -3,-2.0 -1,-0.3 2,-0.2 -2,-0.2 0.007 128.0 -94.1-123.8 24.5 39.3 69.0 11.0 56 87 A G T < 5S+ 0 0 54 -3,-1.9 2,-0.6 1,-0.2 -3,-0.2 0.672 83.2 133.6 73.4 16.6 38.7 70.9 7.8 57 88 A Q < - 0 0 130 -5,-2.3 2,-0.2 -6,-0.1 -1,-0.2 -0.897 35.5-166.5-105.1 122.0 37.0 68.0 6.0 58 89 A H - 0 0 126 -2,-0.6 3,-0.1 -3,-0.1 2,-0.1 -0.677 27.8 -95.8-106.8 158.4 33.8 68.8 4.1 59 90 A K - 0 0 52 -2,-0.2 2,-0.2 1,-0.1 -35,-0.1 -0.374 53.2 -91.9 -67.5 149.3 31.0 66.6 2.6 60 91 A Q E -A 23 0A 61 -37,-0.6 -37,-2.3 1,-0.1 2,-0.4 -0.440 39.5-125.0 -64.5 127.5 31.4 65.9 -1.1 61 92 A R E +A 22 0A 136 -39,-0.2 15,-2.2 -2,-0.2 16,-0.4 -0.615 46.3 166.0 -75.4 128.9 29.5 68.5 -3.1 62 93 A I E -AC 21 75A 0 -41,-3.2 -41,-2.5 -2,-0.4 2,-0.4 -0.814 40.7-122.0-139.6 178.5 27.0 66.6 -5.4 63 94 A W E -AC 20 74A 61 11,-2.4 11,-2.5 -2,-0.2 2,-0.8 -0.992 19.6-151.6-121.8 125.7 24.0 66.7 -7.7 64 95 A V E -AC 19 73A 0 -45,-3.3 -45,-2.6 -2,-0.4 2,-0.5 -0.913 18.0-165.6-101.3 110.6 21.1 64.5 -6.8 65 96 A N E -AC 18 72A 14 7,-2.7 7,-2.5 -2,-0.8 2,-0.5 -0.882 2.5-164.7-102.0 123.1 19.5 63.7 -10.1 66 97 A I E +AC 17 71A 0 -49,-2.7 -49,-2.2 -2,-0.5 2,-0.3 -0.932 27.6 127.3-113.5 121.2 16.0 62.2 -10.0 67 98 A S E > S- C 0 70A 0 3,-2.4 3,-2.7 -2,-0.5 -54,-0.2 -0.876 75.0 -74.5-153.7-176.3 14.4 60.5 -13.1 68 99 A L T 3 S+ 0 0 58 -56,-2.5 19,-0.4 1,-0.3 -55,-0.1 0.745 126.7 65.6 -60.0 -21.9 12.7 57.3 -14.3 69 100 A S T 3 S- 0 0 55 -55,-0.3 2,-0.4 -57,-0.3 -1,-0.3 0.554 113.0-123.9 -76.4 -8.3 16.2 55.9 -14.1 70 101 A G E < -C 67 0A 0 -3,-2.7 -3,-2.4 16,-0.2 2,-0.4 -0.849 57.2 -14.7 104.0-137.8 16.0 56.3 -10.4 71 102 A I E -CD 66 85A 0 14,-2.4 14,-2.7 -2,-0.4 2,-0.5 -0.897 51.7-168.8-112.4 134.2 18.6 58.3 -8.4 72 103 A K E -CD 65 84A 39 -7,-2.5 -7,-2.7 -2,-0.4 2,-0.7 -0.979 9.3-155.7-119.7 127.2 22.0 59.4 -9.7 73 104 A I E -CD 64 83A 0 10,-2.5 10,-1.6 -2,-0.5 9,-1.6 -0.923 22.3-174.4-100.4 117.5 24.5 60.9 -7.3 74 105 A I E -CD 63 81A 27 -11,-2.5 -11,-2.4 -2,-0.7 2,-0.3 -0.933 27.9-118.0-118.9 138.9 26.9 63.0 -9.3 75 106 A D E > -C 62 0A 22 5,-2.5 4,-1.8 -2,-0.4 -13,-0.3 -0.578 19.2-145.5 -72.9 129.0 30.1 64.8 -8.2 76 107 A E T 4 S+ 0 0 68 -15,-2.2 -1,-0.2 -2,-0.3 -14,-0.1 0.848 94.0 45.2 -64.5 -35.3 29.6 68.5 -8.7 77 108 A K T 4 S+ 0 0 192 -16,-0.4 -1,-0.2 1,-0.1 -15,-0.1 0.967 126.8 21.7 -73.9 -55.9 33.2 69.1 -9.7 78 109 A T T 4 S- 0 0 93 2,-0.1 -2,-0.2 1,-0.0 -1,-0.1 0.746 89.7-130.5 -87.3 -27.5 34.0 66.3 -12.1 79 110 A G < + 0 0 47 -4,-1.8 2,-0.3 1,-0.3 -3,-0.1 0.620 54.2 153.2 84.0 10.6 30.5 65.3 -13.3 80 111 A V - 0 0 75 -5,-0.1 -5,-2.5 1,-0.1 2,-1.1 -0.564 50.9-122.8 -76.1 135.1 31.4 61.7 -12.6 81 112 A I E +D 74 0A 89 -2,-0.3 -7,-0.2 -7,-0.2 3,-0.1 -0.702 32.4 179.2 -83.2 102.5 28.4 59.5 -11.8 82 113 A E E + 0 0 76 -9,-1.6 2,-0.3 -2,-1.1 -1,-0.2 0.893 63.9 5.2 -69.6 -46.2 29.3 58.2 -8.3 83 114 A H E -D 73 0A 53 -10,-1.6 -10,-2.5 2,-0.0 2,-0.4 -0.987 54.6-169.9-142.8 152.6 26.1 56.1 -7.8 84 115 A E E -D 72 0A 101 -2,-0.3 -12,-0.2 -12,-0.2 -14,-0.1 -0.970 6.2-174.1-143.7 125.6 23.0 55.1 -9.6 85 116 A H E -D 71 0A 23 -14,-2.7 -14,-2.4 -2,-0.4 5,-0.1 -0.950 20.5-135.8-126.6 112.6 20.1 53.4 -8.0 86 117 A P >> - 0 0 49 0, 0.0 3,-2.6 0, 0.0 4,-0.5 -0.290 28.3-111.2 -61.9 147.8 17.2 52.2 -10.1 87 118 A V G >4 S+ 0 0 7 -19,-0.4 3,-1.4 1,-0.3 -17,-0.1 0.864 117.9 59.8 -48.7 -41.7 13.7 52.9 -8.8 88 119 A N G 34 S+ 0 0 76 1,-0.3 374,-2.1 373,-0.1 -1,-0.3 0.349 103.8 52.3 -73.1 9.5 13.1 49.2 -8.1 89 120 A K G <4 S+ 0 0 74 -3,-2.6 19,-2.1 372,-0.2 2,-0.8 0.440 87.1 86.7-119.6 -7.8 16.2 49.2 -5.8 90 121 A I E << +E 107 0A 0 -3,-1.4 17,-0.3 -4,-0.5 370,-0.1 -0.868 49.8 171.1 -96.6 110.2 15.2 52.1 -3.5 91 122 A S E + 0 0 0 15,-1.4 367,-2.4 -2,-0.8 2,-0.4 0.785 58.7 22.0 -92.3 -30.5 13.0 50.6 -0.8 92 123 A F E -EF 106 457A 8 14,-1.2 14,-2.9 365,-0.3 2,-0.6 -0.998 54.1-154.1-145.4 139.6 12.5 53.5 1.6 93 124 A I E -EF 105 456A 1 363,-2.8 363,-2.1 -2,-0.4 2,-0.5 -0.964 23.0-152.2-112.0 121.5 12.7 57.2 1.6 94 125 A A E -E 104 0A 3 10,-3.2 10,-2.5 -2,-0.6 2,-0.3 -0.847 3.3-150.9-102.0 130.4 13.5 58.6 5.0 95 126 A R E -E 103 0A 69 -2,-0.5 2,-0.8 8,-0.2 8,-0.2 -0.732 14.3-139.1 -92.2 140.7 12.5 62.1 6.1 96 127 A D > - 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