==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 04-AUG-02 1MC0 . COMPND 2 MOLECULE: 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A; . SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; . AUTHOR S.MARTINEZ,A.WU,N.GLAVAS,X.TANG,S.TURLEY,W.HOL,J.BEAVO . 341 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 19473.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 255 74.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 68 19.9 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 3 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 23 6.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 29 8.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 129 37.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 1 0 1 0 1 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 4 1 1 0 1 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 215 A Y >> 0 0 174 0, 0.0 3,-2.5 0, 0.0 4,-2.1 0.000 360.0 360.0 360.0 148.4 91.3 35.6 52.9 2 216 A T H 3> + 0 0 116 1,-0.3 4,-1.4 2,-0.3 5,-0.2 0.676 360.0 66.6 -53.3 -13.2 95.0 35.2 52.3 3 217 A D H 3> S+ 0 0 77 2,-0.2 4,-1.1 1,-0.2 -1,-0.3 0.899 111.2 31.4 -71.4 -41.1 94.8 39.0 52.1 4 218 A H H <> S+ 0 0 18 -3,-2.5 4,-1.8 2,-0.2 -2,-0.3 0.615 111.4 67.2 -89.2 -16.8 93.9 38.8 55.8 5 219 A D H X S+ 0 0 66 -4,-2.1 4,-1.6 2,-0.2 -3,-0.2 0.849 106.9 40.5 -71.8 -33.8 96.1 35.7 56.4 6 220 A R H X S+ 0 0 172 -4,-1.4 4,-1.7 -5,-0.2 -2,-0.2 0.900 112.7 54.0 -79.6 -42.2 99.1 37.8 55.7 7 221 A K H X S+ 0 0 51 -4,-1.1 4,-1.6 1,-0.2 -2,-0.2 0.850 109.5 50.7 -58.5 -36.0 97.9 40.8 57.6 8 222 A I H X S+ 0 0 5 -4,-1.8 4,-3.3 2,-0.2 3,-0.3 0.966 104.1 54.3 -66.8 -55.3 97.3 38.6 60.6 9 223 A L H X S+ 0 0 125 -4,-1.6 4,-2.4 1,-0.3 -1,-0.2 0.853 109.4 50.9 -49.8 -35.0 100.8 37.0 60.6 10 224 A Q H X S+ 0 0 147 -4,-1.7 4,-1.0 2,-0.2 -1,-0.3 0.911 109.4 48.8 -69.8 -41.3 102.1 40.5 60.7 11 225 A L H >< S+ 0 0 14 -4,-1.6 3,-1.3 -3,-0.3 4,-0.3 0.970 110.5 53.3 -60.1 -50.4 99.9 41.4 63.7 12 226 A C H >< S+ 0 0 39 -4,-3.3 3,-2.5 1,-0.3 -2,-0.2 0.919 106.3 49.9 -47.6 -56.8 101.1 38.2 65.4 13 227 A G H 3< S+ 0 0 53 -4,-2.4 -1,-0.3 1,-0.3 -2,-0.2 0.721 109.4 55.8 -57.8 -19.7 104.7 39.0 65.0 14 228 A E T << S+ 0 0 97 -3,-1.3 2,-0.9 -4,-1.0 3,-0.3 0.383 84.0 85.2 -94.6 2.8 103.9 42.4 66.5 15 229 A L < + 0 0 16 -3,-2.5 -1,-0.2 -4,-0.3 8,-0.1 -0.556 50.5 119.9-102.5 65.6 102.3 41.0 69.6 16 230 A F + 0 0 137 -2,-0.9 -1,-0.2 -3,-0.1 -2,-0.1 0.530 36.9 118.5-105.4 -9.4 105.6 40.7 71.5 17 231 A D - 0 0 39 -3,-0.3 142,-0.1 1,-0.1 6,-0.0 -0.176 58.5-144.6 -59.8 149.3 104.7 43.0 74.5 18 232 A L S S+ 0 0 146 4,-0.0 2,-0.5 5,-0.0 -1,-0.1 0.485 79.5 81.8 -93.4 -4.9 104.7 41.6 78.0 19 233 A D S > S- 0 0 57 1,-0.1 4,-1.5 144,-0.0 3,-0.2 -0.892 71.8-145.5-105.9 129.0 101.8 43.8 79.0 20 234 A A H > S+ 0 0 2 -2,-0.5 4,-1.4 139,-0.4 -1,-0.1 0.848 98.7 58.8 -58.8 -38.7 98.2 42.7 78.1 21 235 A T H > S+ 0 0 28 1,-0.2 4,-2.4 2,-0.2 3,-0.3 0.922 106.1 47.3 -57.7 -46.8 97.1 46.3 77.6 22 236 A S H > S+ 0 0 36 1,-0.2 4,-1.3 -3,-0.2 -1,-0.2 0.834 109.2 54.1 -65.5 -33.5 99.7 46.9 74.9 23 237 A L H X S+ 0 0 0 -4,-1.5 4,-1.2 2,-0.2 -1,-0.2 0.761 110.2 49.2 -71.9 -25.0 98.7 43.6 73.2 24 238 A Q H X S+ 0 0 3 -4,-1.4 4,-4.0 -3,-0.3 5,-0.3 0.949 103.9 55.6 -78.2 -51.8 95.2 44.9 73.1 25 239 A L H X S+ 0 0 33 -4,-2.4 4,-2.0 1,-0.3 -2,-0.2 0.829 111.4 47.8 -48.4 -37.3 95.8 48.3 71.7 26 240 A K H X S+ 0 0 55 -4,-1.3 4,-1.0 2,-0.2 -1,-0.3 0.888 115.8 41.3 -74.2 -41.2 97.6 46.6 68.8 27 241 A V H X S+ 0 0 0 -4,-1.2 4,-2.0 -3,-0.2 -2,-0.2 0.897 115.5 51.9 -71.8 -41.0 94.8 44.1 68.1 28 242 A L H X S+ 0 0 1 -4,-4.0 4,-2.3 1,-0.2 -2,-0.2 0.941 109.8 48.3 -59.7 -48.7 92.1 46.7 68.6 29 243 A Q H < S+ 0 0 81 -4,-2.0 4,-0.4 -5,-0.3 -1,-0.2 0.769 106.8 57.5 -65.3 -25.7 93.8 49.1 66.2 30 244 A Y H >X S+ 0 0 18 -4,-1.0 4,-2.2 1,-0.2 3,-1.3 0.964 109.7 44.5 -66.5 -50.2 94.1 46.2 63.6 31 245 A L H 3X S+ 0 0 3 -4,-2.0 4,-1.6 1,-0.3 6,-0.5 0.861 102.6 64.8 -61.7 -38.9 90.3 45.7 63.8 32 246 A Q H 3< S+ 0 0 37 -4,-2.3 -1,-0.3 2,-0.2 -2,-0.2 0.673 111.4 39.0 -61.7 -13.2 89.5 49.4 63.6 33 247 A Q H <4 S+ 0 0 131 -3,-1.3 3,-0.3 -4,-0.4 -2,-0.2 0.860 114.0 48.6 -98.3 -57.7 91.1 49.3 60.1 34 248 A E H < S+ 0 0 42 -4,-2.2 -2,-0.2 1,-0.2 -3,-0.2 0.608 126.2 31.7 -59.2 -11.4 89.8 46.0 58.8 35 249 A T S < S- 0 0 2 -4,-1.6 -1,-0.2 -5,-0.2 -3,-0.2 0.539 99.0-130.3-119.7 -17.9 86.3 46.9 59.9 36 250 A Q + 0 0 88 -5,-0.4 96,-1.8 -3,-0.3 97,-0.4 0.776 52.3 157.2 71.1 26.0 86.4 50.7 59.5 37 251 A A E -A 131 0A 7 -6,-0.5 -1,-0.2 94,-0.2 94,-0.2 -0.605 45.3-140.1 -85.8 145.5 85.0 51.0 63.0 38 252 A T E S+ 0 0 63 92,-1.7 2,-0.4 91,-1.4 92,-0.2 0.919 86.0 11.4 -68.2 -46.3 85.5 54.3 65.0 39 253 A H E -A 129 0A 53 90,-1.5 90,-2.6 19,-0.1 2,-0.3 -0.999 65.6-173.9-138.3 139.1 86.2 52.5 68.3 40 254 A C E +A 128 0A 1 -2,-0.4 18,-2.0 88,-0.2 2,-0.3 -0.838 9.0 169.5-124.9 163.0 86.8 48.9 69.2 41 255 A C E -AB 127 57A 5 86,-1.6 86,-3.2 -2,-0.3 2,-0.5 -0.957 29.1-125.7-170.4 153.4 87.1 47.2 72.6 42 256 A L E -A 126 0A 7 14,-0.7 2,-0.8 -2,-0.3 13,-0.4 -0.916 13.7-156.6-107.5 129.5 87.3 43.9 74.3 43 257 A L E -A 125 0A 0 82,-2.5 82,-2.1 -2,-0.5 2,-0.3 -0.924 21.7-147.2-105.5 107.0 84.9 43.1 77.1 44 258 A L E -AC 124 53A 27 9,-2.9 9,-2.2 -2,-0.8 2,-0.4 -0.592 5.3-132.1 -81.1 133.7 86.6 40.4 79.1 45 259 A V E - C 0 52A 15 78,-2.6 7,-0.2 -2,-0.3 -1,-0.0 -0.720 26.1-131.9 -84.6 128.4 84.6 37.7 80.9 46 260 A S - 0 0 34 5,-2.2 3,-0.3 -2,-0.4 -1,-0.1 0.085 22.6-101.0 -68.3-175.8 85.7 37.2 84.5 47 261 A E S S+ 0 0 151 1,-0.2 -1,-0.1 2,-0.1 -2,-0.0 0.952 121.2 50.3 -73.4 -53.0 86.4 33.9 86.3 48 262 A D S S- 0 0 96 1,-0.1 -1,-0.2 0, 0.0 -2,-0.0 0.434 109.6-124.5 -66.0 2.7 83.1 33.5 88.1 49 263 A N S S+ 0 0 84 -3,-0.3 -1,-0.1 2,-0.1 -2,-0.1 0.728 84.4 111.4 58.9 21.5 81.5 34.2 84.7 50 264 A L + 0 0 104 19,-0.1 20,-2.2 20,-0.1 21,-0.4 0.624 66.4 37.7-102.4 -14.6 79.7 37.0 86.5 51 265 A Q E - D 0 69A 72 18,-0.2 -5,-2.2 19,-0.1 2,-0.4 -0.914 55.9-138.9-141.5 167.1 81.1 40.1 85.0 52 266 A L E -CD 45 68A 0 16,-2.2 16,-1.7 -2,-0.3 2,-0.3 -0.974 25.0-170.9-120.3 133.1 82.5 42.0 82.0 53 267 A S E -CD 44 67A 18 -9,-2.2 -9,-2.9 -2,-0.4 2,-0.3 -0.892 7.1-168.9-125.4 155.7 85.5 44.2 82.2 54 268 A C E + D 0 66A 0 12,-2.2 12,-2.6 -2,-0.3 -11,-0.1 -0.986 18.4 161.7-146.1 134.5 87.2 46.6 79.9 55 269 A K E + 0 0 51 -13,-0.4 7,-1.5 -2,-0.3 2,-0.5 0.616 69.7 47.2-120.4 -32.2 90.6 48.3 80.1 56 270 A V E - D 0 61A 0 -14,-0.3 -14,-0.7 5,-0.2 2,-0.5 -0.967 53.6-179.6-122.8 127.1 91.3 49.4 76.6 57 271 A I E > -BD 41 60A 14 3,-3.0 3,-1.7 -2,-0.5 2,-1.3 -0.910 69.3 -47.4-125.6 103.4 88.9 51.3 74.3 58 272 A G T 3 S- 0 0 0 -18,-2.0 -29,-0.2 -2,-0.5 -26,-0.1 -0.626 121.4 -29.2 80.4 -95.8 90.3 52.1 70.8 59 273 A D T 3 S+ 0 0 110 -2,-1.3 2,-0.5 -31,-0.1 -1,-0.3 0.074 118.4 104.2-138.9 11.7 93.7 53.6 71.6 60 274 A K E < -D 57 0A 121 -3,-1.7 -3,-3.0 -35,-0.0 2,-0.9 -0.894 59.3-153.2-105.8 121.1 92.6 54.9 74.9 61 275 A V E -D 56 0A 60 -2,-0.5 -5,-0.2 -5,-0.2 4,-0.0 -0.836 24.8-128.4 -96.2 102.9 93.7 53.1 78.1 62 276 A L E - 0 0 33 -7,-1.5 3,-0.0 -2,-0.9 39,-0.0 -0.245 9.6-133.5 -51.2 129.4 91.0 53.8 80.7 63 277 A G E S+ 0 0 66 1,-0.1 2,-0.4 2,-0.0 -1,-0.2 0.811 96.4 30.5 -56.6 -30.2 92.8 55.1 83.8 64 278 A E E S- 0 0 160 -9,-0.0 2,-0.2 0, 0.0 -1,-0.1 -0.995 94.0-114.2-131.3 135.9 90.6 52.7 85.8 65 279 A E E - 0 0 90 -2,-0.4 2,-0.4 1,-0.1 -10,-0.2 -0.488 31.1-137.6 -70.1 135.2 89.3 49.4 84.5 66 280 A V E +D 54 0A 44 -12,-2.6 -12,-2.2 -2,-0.2 2,-0.3 -0.790 26.1 173.1 -98.4 137.1 85.5 49.3 84.1 67 281 A S E +D 53 0A 52 -2,-0.4 -14,-0.2 -14,-0.2 -16,-0.0 -0.984 5.8 171.3-140.8 151.2 83.4 46.3 85.1 68 282 A F E -D 52 0A 15 -16,-1.7 -16,-2.2 -2,-0.3 -2,-0.0 -0.983 39.3 -86.9-156.3 153.3 79.7 45.5 85.4 69 283 A P E -D 51 0A 53 0, 0.0 -18,-0.2 0, 0.0 7,-0.2 -0.238 25.6-132.1 -61.0 148.2 77.4 42.4 86.0 70 284 A L S S+ 0 0 24 -20,-2.2 6,-0.7 1,-0.2 7,-0.2 0.757 107.7 67.1 -71.0 -23.7 76.4 40.2 83.1 71 285 A T S S+ 0 0 128 -21,-0.4 2,-4.6 1,-0.2 -1,-0.2 0.970 79.1 85.4 -52.2 -60.0 72.8 40.4 84.6 72 286 A M S S- 0 0 99 2,-0.1 2,-0.3 4,-0.1 -1,-0.2 -0.034 103.5 -37.1 -40.8 46.3 72.9 44.1 83.7 73 287 A G S S- 0 0 27 -2,-4.6 4,-0.3 1,-0.1 3,-0.2 -0.802 82.7 -48.0 134.3-174.0 71.7 43.6 80.1 74 288 A R S >> S+ 0 0 52 -2,-0.3 3,-1.2 1,-0.2 4,-0.8 0.741 110.3 73.9 -75.4 -29.6 71.6 41.7 76.8 75 289 A L H >> S+ 0 0 5 1,-0.3 3,-1.0 2,-0.2 4,-1.0 0.859 86.6 62.8 -55.3 -42.5 75.4 41.2 76.5 76 290 A G H 3> S+ 0 0 15 -6,-0.7 4,-0.8 1,-0.3 3,-0.3 0.797 98.2 57.6 -56.4 -28.1 75.6 38.6 79.3 77 291 A Q H <> S+ 0 0 100 -3,-1.2 4,-3.4 -4,-0.3 3,-0.4 0.832 95.0 63.6 -72.8 -30.9 73.4 36.4 77.1 78 292 A V H > -E 110 0A 52 -2,-0.3 3,-2.9 24,-0.2 4,-0.6 -0.851 39.2 -81.5-138.7 174.9 74.2 44.4 67.0 87 301 A L G >4 S+ 0 0 45 22,-1.3 3,-1.6 1,-0.3 8,-0.1 0.840 122.9 59.8 -41.8 -49.4 73.1 47.8 68.2 88 302 A K G 34 S+ 0 0 149 1,-0.3 -1,-0.3 21,-0.2 20,-0.0 0.687 103.5 55.6 -57.7 -19.0 69.4 47.1 67.5 89 303 A D G <4 S+ 0 0 55 -3,-2.9 -1,-0.3 2,-0.0 -2,-0.2 0.652 83.9 101.8 -90.3 -18.1 69.7 44.2 70.0 90 304 A L S << S- 0 0 18 -3,-1.6 -17,-0.0 -4,-0.6 -3,-0.0 -0.425 71.0-121.2 -75.2 143.4 71.0 46.1 73.0 91 305 A T > - 0 0 58 -2,-0.1 4,-1.7 1,-0.1 5,-0.2 -0.131 32.9-104.3 -66.8 171.6 68.8 47.0 75.9 92 306 A S H > S+ 0 0 99 1,-0.2 4,-2.5 2,-0.2 5,-0.1 0.914 125.2 53.0 -66.5 -38.7 68.5 50.7 76.8 93 307 A D H > S+ 0 0 78 2,-0.2 4,-3.2 1,-0.2 -1,-0.2 0.900 104.3 54.1 -61.6 -44.7 70.8 49.9 79.7 94 308 A D H > S+ 0 0 4 2,-0.2 4,-3.3 1,-0.2 5,-0.3 0.919 111.1 45.6 -55.7 -47.9 73.4 48.3 77.5 95 309 A V H X S+ 0 0 32 -4,-1.7 4,-2.3 2,-0.2 -1,-0.2 0.939 112.2 51.4 -62.4 -46.7 73.6 51.4 75.3 96 310 A Q H X S+ 0 0 109 -4,-2.5 4,-1.8 2,-0.2 -2,-0.2 0.943 114.7 44.1 -55.8 -48.8 73.7 53.6 78.4 97 311 A Q H >X S+ 0 0 46 -4,-3.2 4,-2.0 1,-0.2 3,-0.8 0.978 113.8 46.5 -61.8 -59.0 76.5 51.6 79.8 98 312 A L H 3X S+ 0 0 4 -4,-3.3 4,-2.7 1,-0.3 -1,-0.2 0.802 114.5 51.4 -56.0 -27.0 78.5 51.2 76.6 99 313 A Q H 3X S+ 0 0 45 -4,-2.3 4,-2.0 -5,-0.3 5,-0.5 0.801 103.6 55.0 -80.3 -29.5 78.0 54.9 76.1 100 314 A N H << S+ 0 0 97 -4,-1.8 -2,-0.2 -3,-0.8 -1,-0.2 0.896 116.9 40.4 -66.5 -37.7 79.2 55.9 79.6 101 315 A M H < S+ 0 0 29 -4,-2.0 -2,-0.2 -5,-0.2 -3,-0.1 0.946 119.3 41.7 -72.9 -55.0 82.4 54.0 78.7 102 316 A L H < S- 0 0 23 -4,-2.7 -3,-0.2 -5,-0.2 -2,-0.2 0.777 95.9-143.0 -64.6 -30.2 82.8 55.1 75.1 103 317 A G < + 0 0 64 -4,-2.0 2,-0.3 1,-0.2 -3,-0.1 0.792 65.3 77.5 70.3 29.7 81.9 58.6 76.0 104 318 A C S S- 0 0 45 -5,-0.5 -1,-0.2 0, 0.0 -2,-0.1 -0.978 92.5 -67.3-159.4 167.5 80.0 59.3 72.8 105 319 A E - 0 0 160 -2,-0.3 2,-1.0 1,-0.1 0, 0.0 -0.367 46.4-132.5 -60.2 133.5 76.7 58.7 70.9 106 320 A L + 0 0 15 1,-0.2 3,-0.1 -2,-0.1 -1,-0.1 -0.793 39.3 160.1 -95.5 100.4 76.4 55.0 70.0 107 321 A Q + 0 0 75 -2,-1.0 2,-0.3 1,-0.3 -1,-0.2 0.741 62.4 7.5 -92.2 -27.4 75.4 55.0 66.3 108 322 A A - 0 0 0 -21,-0.1 22,-2.5 28,-0.0 2,-0.3 -0.992 62.6-175.8-156.0 147.7 76.4 51.4 65.3 109 323 A M E - F 0 129A 3 -2,-0.3 -22,-1.3 26,-0.3 2,-0.4 -0.992 15.3-178.1-154.1 146.8 77.5 48.2 66.9 110 324 A L E -EF 86 128A 5 18,-1.9 18,-2.3 -2,-0.3 2,-0.4 -0.988 12.3-168.8-134.6 137.5 78.7 44.7 66.2 111 325 A C E -EF 85 127A 0 -26,-1.9 -26,-1.0 -2,-0.4 16,-0.2 -0.862 3.5-175.4-136.6 101.9 79.6 42.3 69.0 112 326 A V E - F 0 126A 3 14,-2.1 14,-2.7 -2,-0.4 2,-0.2 -0.812 22.3-132.1 -97.1 129.7 81.3 39.0 68.2 113 327 A P E - F 0 125A 12 0, 0.0 2,-0.6 0, 0.0 12,-0.2 -0.589 14.7-134.7 -80.7 146.8 81.9 36.6 71.0 114 328 A V E - F 0 124A 23 10,-3.4 9,-2.6 -2,-0.2 10,-1.0 -0.893 20.1-156.6-103.2 116.6 85.5 35.1 71.3 115 329 A I E - F 0 122A 66 -2,-0.6 7,-0.2 7,-0.2 2,-0.1 -0.822 14.8-125.2-103.0 123.5 85.4 31.4 71.9 116 330 A S > - 0 0 27 5,-2.9 4,-1.3 -2,-0.6 34,-0.1 -0.360 8.1-156.7 -61.6 131.7 88.3 29.5 73.5 117 331 A R T 4 S+ 0 0 194 2,-0.2 -1,-0.2 1,-0.1 33,-0.0 0.691 96.1 52.6 -79.1 -20.4 89.5 26.6 71.4 118 332 A A T 4 S+ 0 0 95 3,-0.1 -1,-0.1 1,-0.1 -2,-0.0 0.896 132.1 7.1 -81.9 -41.9 90.8 25.2 74.6 119 333 A T T 4 S- 0 0 88 2,-0.2 -2,-0.2 0, 0.0 3,-0.1 0.526 88.3-131.2-116.9 -14.7 87.7 25.3 76.8 120 334 A D < + 0 0 95 -4,-1.3 2,-0.3 1,-0.3 -3,-0.1 0.750 64.4 128.9 65.4 26.9 85.1 26.3 74.2 121 335 A Q S S- 0 0 103 -7,-0.0 -5,-2.9 1,-0.0 2,-0.8 -0.704 72.3 -97.4-106.8 159.4 83.8 29.0 76.6 122 336 A V E + F 0 115A 7 -43,-0.4 -7,-0.2 -2,-0.3 3,-0.1 -0.702 39.8 178.8 -81.3 114.2 83.3 32.7 75.7 123 337 A V E - 0 0 43 -9,-2.6 -78,-2.6 -2,-0.8 2,-0.3 0.836 62.0 -16.9 -83.2 -36.1 86.4 34.4 76.9 124 338 A A E -AF 44 114A 5 -10,-1.0 -10,-3.4 -80,-0.2 2,-0.5 -0.960 57.4-113.8-160.8 173.3 85.4 37.8 75.8 125 339 A L E -AF 43 113A 0 -82,-2.1 -82,-2.5 -2,-0.3 2,-0.6 -0.981 25.2-150.2-120.9 113.8 83.2 40.0 73.6 126 340 A A E -AF 42 112A 2 -14,-2.7 -14,-2.1 -2,-0.5 2,-0.4 -0.776 20.5-160.5 -85.7 120.9 85.0 41.8 70.8 127 341 A C E -AF 41 111A 2 -86,-3.2 -86,-1.6 -2,-0.6 2,-0.5 -0.903 16.7-168.9-115.5 132.4 83.1 45.1 70.0 128 342 A A 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462 A V H X S+ 0 0 0 -4,-1.9 4,-3.2 -3,-0.5 5,-0.3 0.868 109.2 57.2 -80.9 -39.4 136.9 48.3 121.0 249 463 A A H < S+ 0 0 13 -4,-2.3 -2,-0.2 -5,-0.2 -1,-0.2 0.720 113.8 42.9 -61.8 -19.6 135.7 45.8 118.4 250 464 A T H < S+ 0 0 96 -4,-1.0 -1,-0.2 -5,-0.2 -2,-0.2 0.770 124.3 30.3 -98.2 -31.9 139.4 45.3 117.6 251 465 A T H < S- 0 0 65 -4,-1.4 -2,-0.2 2,-0.1 -3,-0.2 0.593 89.3-140.5-102.0 -14.1 141.0 45.2 121.1 252 466 A G < + 0 0 7 -4,-3.2 2,-0.5 1,-0.2 -3,-0.1 0.719 62.7 125.2 61.4 18.8 138.0 43.6 122.8 253 467 A Q - 0 0 142 -6,-0.3 -1,-0.2 -5,-0.3 -2,-0.1 -0.946 68.6-105.9-121.5 127.3 138.8 45.9 125.7 254 468 A I - 0 0 47 -2,-0.5 2,-0.4 -3,-0.1 30,-0.2 0.038 34.3-159.2 -39.3 140.3 136.5 48.5 127.4 255 469 A L E -K 283 0B 43 28,-2.7 28,-2.2 2,-0.0 2,-0.6 -0.994 10.3-166.2-134.3 128.4 137.3 52.1 126.5 256 470 A N E -K 282 0B 32 -2,-0.4 26,-0.2 26,-0.2 57,-0.0 -0.883 9.4-174.3-117.3 99.6 136.3 55.1 128.6 257 471 A I E -K 281 0B 3 24,-3.1 24,-2.6 -2,-0.6 3,-0.3 -0.852 11.6-170.9-101.1 115.3 136.7 58.4 126.7 258 472 A P S S+ 0 0 60 0, 0.0 2,-0.3 0, 0.0 -1,-0.1 0.715 83.9 26.5 -72.3 -27.9 136.1 61.6 128.7 259 473 A D - 0 0 87 1,-0.1 21,-0.2 22,-0.1 20,-0.1 -0.816 64.1-173.2-142.6 98.8 136.2 63.9 125.7 260 474 A A S > S+ 0 0 0 19,-2.7 3,-2.6 -2,-0.3 6,-0.4 0.962 85.9 52.4 -54.3 -59.3 135.2 62.4 122.4 261 475 A Y T 3 S+ 0 0 159 17,-0.6 -1,-0.2 1,-0.3 7,-0.1 0.868 109.4 49.6 -45.1 -48.5 136.1 65.4 120.3 262 476 A A T 3 S+ 0 0 76 3,-0.0 -1,-0.3 2,-0.0 -2,-0.2 0.257 91.1 102.4 -79.4 12.4 139.6 65.7 121.8 263 477 A H X - 0 0 60 -3,-2.6 3,-1.3 1,-0.1 -6,-0.0 -0.860 69.6-139.1-105.4 131.7 140.4 62.0 121.2 264 478 A P T 3 S+ 0 0 122 0, 0.0 -1,-0.1 0, 0.0 -21,-0.1 0.826 103.4 44.3 -49.8 -38.4 142.6 60.8 118.3 265 479 A L T 3 S+ 0 0 70 -23,-0.1 -22,-0.2 2,-0.1 -18,-0.1 0.577 83.3 118.3 -88.6 -10.0 140.3 57.8 117.6 266 480 A F < - 0 0 31 -3,-1.3 2,-0.7 -6,-0.4 -23,-0.1 -0.337 53.1-148.5 -63.1 134.1 136.9 59.6 117.8 267 481 A Y - 0 0 93 1,-0.1 3,-0.5 -25,-0.1 4,-0.3 -0.879 11.8-173.7-106.5 103.9 134.8 59.5 114.6 268 482 A R >> + 0 0 132 -2,-0.7 4,-1.8 1,-0.2 3,-0.9 0.669 62.0 95.6 -70.6 -16.3 132.6 62.7 114.4 269 483 A G T 34 S+ 0 0 12 1,-0.3 4,-0.4 2,-0.2 -1,-0.2 0.864 80.3 50.3 -40.1 -59.6 130.8 61.5 111.3 270 484 A V T >> S+ 0 0 35 -3,-0.5 4,-2.5 1,-0.2 3,-0.5 0.852 112.2 50.8 -51.9 -39.1 127.8 60.0 113.1 271 485 A D H <>>S+ 0 0 10 -3,-0.9 4,-3.9 -4,-0.3 5,-1.1 0.987 108.3 45.7 -66.3 -61.5 127.3 63.2 115.0 272 486 A D H 3<5S+ 0 0 107 -4,-1.8 -1,-0.2 1,-0.2 -2,-0.2 0.429 116.4 52.9 -66.0 8.2 127.4 65.8 112.2 273 487 A S H <45S+ 0 0 95 -3,-0.5 -2,-0.2 -4,-0.4 -1,-0.2 0.808 119.1 28.9-101.4 -58.0 125.0 63.4 110.5 274 488 A T H <5S- 0 0 67 -4,-2.5 -2,-0.2 -5,-0.2 -3,-0.2 0.693 105.9-122.8 -74.7 -22.9 122.4 63.0 113.2 275 489 A G T <5 + 0 0 57 -4,-3.9 2,-0.3 1,-0.3 -3,-0.2 0.774 69.9 128.9 81.7 27.4 123.1 66.5 114.5 276 490 A F < - 0 0 59 -5,-1.1 2,-0.5 -6,-0.3 -1,-0.3 -0.863 52.3-136.1-113.5 148.3 123.9 65.1 118.0 277 491 A R - 0 0 152 -2,-0.3 2,-0.7 -3,-0.1 -9,-0.0 -0.923 7.8-147.3-114.6 123.9 127.1 65.9 119.9 278 492 A T + 0 0 24 -2,-0.5 -17,-0.6 1,-0.2 -18,-0.2 -0.753 23.5 166.5 -91.1 114.4 129.1 63.3 121.8 279 493 A R + 0 0 102 -2,-0.7 -19,-2.7 1,-0.3 2,-0.3 0.939 68.3 8.8 -87.2 -61.0 130.8 64.5 125.0 280 494 A N - 0 0 0 -21,-0.2 21,-1.6 -20,-0.1 2,-0.3 -0.843 62.2-161.8-120.8 159.7 131.8 61.2 126.7 281 495 A I E -KL 257 300B 4 -24,-2.6 -24,-3.1 -2,-0.3 2,-0.7 -0.947 9.6-173.8-146.6 120.6 131.8 57.6 125.5 282 496 A L E -KL 256 299B 0 17,-2.5 17,-1.9 -2,-0.3 2,-0.5 -0.862 21.5-176.1-115.8 93.5 132.0 54.4 127.6 283 497 A C E +KL 255 298B 0 -28,-2.2 -28,-2.7 -2,-0.7 15,-0.2 -0.800 6.2 178.8 -98.3 126.6 132.3 51.6 125.0 284 498 A F E - L 0 297B 0 13,-2.4 13,-2.8 -2,-0.5 2,-0.1 -0.942 24.5-117.3-126.1 147.8 132.4 47.9 126.0 285 499 A P E - L 0 296B 4 0, 0.0 2,-0.5 0, 0.0 11,-0.3 -0.386 8.9-145.5 -82.0 160.5 132.6 44.8 123.9 286 500 A I E - L 0 295B 2 9,-3.0 8,-2.5 -2,-0.1 9,-1.5 -0.921 27.3-172.8-124.6 102.1 130.0 41.9 123.5 287 501 A K E - L 0 293B 64 -2,-0.5 6,-0.2 33,-0.4 2,-0.1 -0.522 15.5-127.9 -96.2 163.6 131.8 38.6 123.0 288 502 A N > - 0 0 52 4,-1.9 3,-2.6 -2,-0.2 -1,-0.1 -0.309 45.0 -82.1 -96.0-176.1 130.6 35.1 122.1 289 503 A E T 3 S+ 0 0 150 1,-0.3 -1,-0.0 2,-0.2 -2,-0.0 0.574 131.0 63.1 -65.4 -7.8 131.2 31.8 123.8 290 504 A N T 3 S- 0 0 113 2,-0.2 -1,-0.3 0, 0.0 3,-0.1 0.327 117.2-117.4 -95.5 4.1 134.5 31.8 121.9 291 505 A Q S < S+ 0 0 153 -3,-2.6 2,-0.5 1,-0.2 -2,-0.2 0.757 72.8 138.6 64.1 24.6 135.4 34.9 123.8 292 506 A E - 0 0 121 -4,-0.0 -4,-1.9 1,-0.0 -1,-0.2 -0.880 63.7-105.7-107.7 132.0 135.5 36.6 120.4 293 507 A V E + L 0 287B 35 -2,-0.5 -6,-0.3 -6,-0.2 3,-0.1 -0.305 42.7 165.2 -55.8 117.4 134.0 40.1 119.8 294 508 A I E - 0 0 54 -8,-2.5 -80,-2.5 1,-0.3 2,-0.3 0.586 68.4 -15.3-106.9 -20.2 130.8 39.7 118.0 295 509 A G E -GL 213 286B 0 -9,-1.5 -9,-3.0 -82,-0.3 -1,-0.3 -0.962 61.1-130.2-168.1 177.4 129.6 43.3 118.6 296 510 A V E -GL 212 285B 0 -84,-3.9 -84,-4.3 -2,-0.3 2,-0.3 -0.951 14.3-159.7-141.1 159.7 130.2 46.4 120.7 297 511 A A E -GL 211 284B 0 -13,-2.8 -13,-2.4 -2,-0.3 2,-0.4 -0.965 3.7-157.4-140.6 156.0 128.1 48.7 122.8 298 512 A E E -GL 210 283B 22 -88,-3.1 -88,-2.2 -2,-0.3 2,-0.5 -0.994 17.2-152.1-146.9 146.2 128.2 52.2 124.2 299 513 A L E -GL 209 282B 0 -17,-1.9 -17,-2.5 -2,-0.4 2,-0.5 -0.887 31.6-154.2-101.1 131.6 126.9 54.5 126.9 300 514 A V E -GL 208 281B 7 -92,-2.9 -92,-1.7 -2,-0.5 -93,-1.5 -0.962 46.9 -3.5-125.6 128.4 127.0 58.1 125.7 301 515 A N E - 0 0 1 -21,-1.6 -94,-1.7 -2,-0.5 -1,-0.2 0.894 68.4-117.1 67.6 110.5 127.2 61.4 127.6 302 516 A K E > -G 206 0B 31 -96,-0.2 3,-0.5 -3,-0.1 2,-0.5 -0.522 24.8-133.6 -73.8 138.0 127.1 61.4 131.4 303 517 A I T 3 S+ 0 0 60 -98,-2.4 4,-0.1 1,-0.3 -1,-0.0 -0.823 87.2 1.3 -93.2 130.2 124.1 63.3 132.8 304 518 A N T 3 S+ 0 0 166 -2,-0.5 -1,-0.3 1,-0.2 3,-0.1 0.960 120.9 80.3 56.3 55.9 125.1 65.7 135.5 305 519 A G S < S- 0 0 29 -3,-0.5 -1,-0.2 1,-0.1 -3,-0.1 -0.925 80.6-122.4-178.7 157.2 128.8 64.9 135.3 306 520 A P S S- 0 0 80 0, 0.0 2,-0.3 0, 0.0 -4,-0.1 0.695 91.0 -22.0 -83.8 -21.4 131.9 65.8 133.2 307 521 A W S S- 0 0 145 -6,-0.1 2,-0.5 -4,-0.1 -27,-0.0 -0.968 85.3 -60.9-171.7 178.6 132.5 62.1 132.3 308 522 A F - 0 0 3 -2,-0.3 -27,-0.1 -51,-0.1 5,-0.1 -0.671 53.8-132.4 -83.8 122.5 131.8 58.5 133.3 309 523 A S > - 0 0 52 -2,-0.5 4,-1.8 -105,-0.2 -1,-0.1 0.199 25.5-100.8 -62.2-179.7 133.2 57.5 136.7 310 524 A K H > S+ 0 0 132 2,-0.2 4,-1.3 1,-0.2 5,-0.1 0.888 126.8 54.6 -69.6 -39.2 135.3 54.5 137.7 311 525 A F H >> S+ 0 0 121 1,-0.2 4,-1.6 2,-0.2 3,-0.6 0.918 107.4 48.7 -57.0 -47.8 132.1 53.0 139.0 312 526 A D H 3> S+ 0 0 1 1,-0.3 4,-1.8 2,-0.2 -1,-0.2 0.891 106.4 57.6 -60.2 -40.3 130.5 53.5 135.6 313 527 A E H 3X S+ 0 0 63 -4,-1.8 4,-0.9 1,-0.2 -1,-0.3 0.793 104.1 53.3 -60.3 -29.7 133.5 51.9 134.1 314 528 A D H X S+ 0 0 66 -4,-0.9 4,-1.8 -3,-0.3 3,-1.0 0.993 115.8 45.1 -66.6 -61.9 132.7 45.3 132.5 318 532 A A H 3X S+ 0 0 57 -4,-2.3 4,-2.7 1,-0.3 -2,-0.2 0.820 115.5 47.2 -49.9 -42.0 129.8 43.6 134.3 319 533 A F H 3X S+ 0 0 9 -4,-3.6 4,-1.6 -5,-0.2 -1,-0.3 0.730 105.0 60.9 -76.1 -21.3 127.4 44.4 131.4 320 534 A S H X S+ 0 0 22 -4,-1.5 4,-2.6 2,-0.2 3,-0.9 0.993 107.2 46.2 -69.9 -67.0 124.0 32.5 125.6 329 543 A H H 3X S+ 0 0 131 -4,-2.2 4,-1.5 1,-0.3 -1,-0.2 0.741 116.1 52.6 -49.2 -23.6 121.0 31.6 127.8 330 544 A S H 3X S+ 0 0 49 -4,-1.1 4,-1.1 2,-0.2 -1,-0.3 0.849 107.6 47.3 -81.3 -39.8 119.0 32.9 124.9 331 545 A L H S+ 0 0 79 -2,-0.4 4,-1.6 -3,-0.4 -1,-0.2 0.386 115.1 44.4-144.7 -45.7 112.0 25.5 123.4 338 552 A E H < S+ 0 0 110 -4,-1.2 -2,-0.2 2,-0.2 -3,-0.1 0.619 118.8 47.5 -81.7 -14.7 111.7 24.9 119.7 339 553 A A T < S+ 0 0 77 -4,-1.7 -3,-0.2 1,-0.1 -1,-0.1 0.880 106.5 54.5 -88.1 -49.4 112.9 21.4 120.2 340 554 A Q T 4 0 0 165 -5,-0.4 -2,-0.2 1,-0.2 -4,-0.1 0.937 360.0 360.0 -46.7 -51.3 110.6 20.6 123.1 341 555 A Y < 0 0 223 -4,-1.6 -1,-0.2 0, 0.0 -4,-0.1 -0.500 360.0 360.0 -64.6 360.0 107.9 21.7 120.7