==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=6-SEP-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER METAL TRANSPORT 13-AUG-13 2MC2 . COMPND 2 MOLECULE: RYANODINE RECEPTOR 2; . SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; . AUTHOR F.AMADOR,P.STATHOPULOS,G.SEABROOK,M.IKURA . 206 1 1 1 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 11930.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 138 67.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 70 34.0 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 3 1.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 24 11.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 12 5.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 19 9.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 6 3 1 2 2 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 12 A Q 0 0 158 0, 0.0 165,-1.7 0, 0.0 2,-0.3 0.000 360.0 360.0 360.0 109.7 4.5 18.1 -0.8 2 13 A F B -A 165 0A 53 163,-0.3 2,-0.5 165,-0.0 163,-0.3 -0.867 360.0-108.3-119.2 153.1 5.8 14.6 -1.5 3 14 A L - 0 0 0 161,-2.6 99,-2.8 -2,-0.3 2,-0.3 -0.670 39.8-164.6 -79.8 126.1 5.1 11.3 0.1 4 15 A R B > -B 101 0B 97 -2,-0.5 3,-1.2 97,-0.2 54,-0.3 -0.777 23.9 -97.9-112.8 156.6 8.1 10.1 2.1 5 16 A T T 3 S+ 0 0 2 95,-2.0 54,-0.2 -2,-0.3 94,-0.2 -0.299 108.1 27.2 -67.5 156.1 9.0 6.7 3.6 6 17 A D T 3 S+ 0 0 80 52,-2.3 2,-0.3 1,-0.3 -1,-0.2 0.417 90.8 141.5 70.9 -2.8 8.3 6.1 7.2 7 18 A D < - 0 0 46 -3,-1.2 51,-2.0 51,-0.4 2,-0.6 -0.525 56.3-124.4 -73.3 133.8 5.5 8.6 6.8 8 19 A E E +C 57 0C 101 -2,-0.3 198,-0.8 49,-0.2 2,-0.3 -0.695 46.7 160.5 -80.8 120.5 2.3 7.8 8.7 9 20 A V E -CD 56 205C 0 47,-3.2 47,-3.0 -2,-0.6 2,-0.4 -0.832 34.9-137.2-136.4 172.0 -0.5 7.8 6.2 10 21 A V E - D 0 204C 6 194,-1.8 194,-1.8 -2,-0.3 2,-0.6 -0.998 18.2-137.1-133.1 135.8 -4.1 6.6 5.6 11 22 A L E + D 0 203C 1 43,-0.4 15,-3.3 -2,-0.4 2,-0.3 -0.834 27.7 179.7 -96.8 123.6 -5.4 5.2 2.4 12 23 A Q E -ED 25 202C 31 190,-1.4 190,-2.8 -2,-0.6 2,-0.3 -0.791 11.3-168.2-120.4 163.1 -8.8 6.4 1.3 13 24 A C E -E 24 0C 2 11,-1.7 11,-2.0 -2,-0.3 2,-0.6 -0.983 25.5-119.2-151.0 139.4 -11.1 5.8 -1.7 14 25 A T E -E 23 0C 65 186,-0.4 2,-0.5 -2,-0.3 9,-0.2 -0.699 29.1-167.9 -83.8 121.4 -14.2 7.4 -3.0 15 26 A A E +E 22 0C 1 7,-2.8 7,-2.0 -2,-0.6 2,-0.4 -0.942 6.9 180.0-114.7 119.1 -17.1 5.1 -3.0 16 27 A T E +E 21 0C 76 -2,-0.5 2,-0.3 5,-0.2 5,-0.2 -0.958 14.5 138.0-122.9 136.9 -20.3 6.1 -4.8 17 28 A I E > +E 20 0C 48 3,-2.7 3,-1.2 -2,-0.4 -2,-0.0 -0.921 61.3 21.2-171.5 145.3 -23.6 4.2 -5.2 18 29 A H T 3 S- 0 0 134 -2,-0.3 3,-0.1 1,-0.3 -1,-0.0 0.867 130.0 -59.9 59.3 37.8 -27.3 4.8 -5.1 19 30 A K T 3 S+ 0 0 202 1,-0.2 2,-0.4 -3,-0.0 -1,-0.3 0.726 117.2 115.0 63.4 22.5 -26.7 8.5 -5.9 20 31 A E E < -E 17 0C 129 -3,-1.2 -3,-2.7 2,-0.0 2,-0.4 -0.987 47.3-165.1-127.6 131.9 -24.7 8.7 -2.7 21 32 A Q E +E 16 0C 134 -2,-0.4 2,-0.3 -5,-0.2 -5,-0.2 -0.907 16.0 155.3-118.8 144.4 -20.9 9.3 -2.4 22 33 A Q E -E 15 0C 51 -7,-2.0 -7,-2.8 -2,-0.4 2,-0.4 -0.941 34.1-116.0-154.0 171.9 -18.6 8.8 0.6 23 34 A K E -E 14 0C 92 -2,-0.3 18,-2.0 18,-0.2 2,-0.4 -0.945 23.9-168.4-119.4 141.1 -15.0 8.2 1.5 24 35 A L E -EF 13 40C 6 -11,-2.0 -11,-1.7 -2,-0.4 2,-0.4 -0.980 11.4-143.0-130.2 142.0 -13.5 5.2 3.1 25 36 A a E -EF 12 39C 0 14,-1.9 14,-2.1 -2,-0.4 2,-0.5 -0.858 31.9-104.3-106.4 138.2 -10.1 4.5 4.7 26 37 A L E - F 0 38C 0 -15,-3.3 -15,-0.3 -2,-0.4 12,-0.2 -0.426 50.4-176.2 -60.0 110.5 -8.3 1.2 4.5 27 38 A A E + F 0 37C 0 10,-2.8 10,-2.3 -2,-0.5 2,-0.3 -0.666 10.9 162.4-109.8 165.2 -8.8 -0.3 7.9 28 39 A A - 0 0 0 25,-0.6 2,-0.3 8,-0.2 8,-0.1 -0.978 21.9-140.6-169.9 167.1 -7.5 -3.5 9.5 29 40 A E - 0 0 34 -2,-0.3 109,-0.2 6,-0.3 83,-0.0 -0.981 18.3-135.8-140.0 150.6 -6.9 -5.3 12.7 30 41 A G S S+ 0 0 22 -2,-0.3 2,-0.3 3,-0.0 -1,-0.0 0.486 85.6 76.7 -84.1 -2.6 -4.1 -7.5 14.1 31 42 A F S > S+ 0 0 153 4,-0.1 3,-0.8 2,-0.0 2,-0.2 -0.758 90.2 5.8-108.8 156.1 -6.6 -10.0 15.5 32 43 A G T 3 S- 0 0 57 -2,-0.3 0, 0.0 1,-0.2 0, 0.0 -0.552 130.7 -16.5 80.1-141.6 -8.7 -12.6 13.8 33 44 A N T 3 S- 0 0 103 -2,-0.2 105,-0.3 2,-0.1 -1,-0.2 0.333 82.3-134.3 -81.1 7.9 -8.2 -13.3 10.1 34 45 A R < + 0 0 73 -3,-0.8 104,-1.4 1,-0.2 2,-0.2 0.745 47.1 164.6 43.1 30.0 -6.4 -9.9 10.0 35 46 A L B -G 137 0C 46 102,-0.2 102,-0.3 -4,-0.2 -6,-0.3 -0.544 35.7-120.2 -78.3 139.6 -8.4 -9.2 6.8 36 47 A C + 0 0 12 100,-2.9 156,-0.5 -2,-0.2 100,-0.2 -0.469 37.7 164.9 -80.1 150.5 -8.5 -5.6 5.7 37 48 A F E -F 27 0C 62 -10,-2.3 -10,-2.8 -2,-0.2 2,-0.4 -0.732 31.9 -96.2-145.0-168.6 -11.8 -3.7 5.3 38 49 A L E -F 26 0C 16 152,-0.6 2,-0.4 -12,-0.2 -12,-0.2 -0.962 21.0-150.1-128.6 143.9 -12.9 -0.1 4.9 39 50 A E E -F 25 0C 24 -14,-2.1 -14,-1.9 -2,-0.4 2,-0.3 -0.886 20.3-123.6-110.6 139.1 -14.1 2.5 7.4 40 51 A S E -F 24 0C 36 -2,-0.4 3,-0.2 -16,-0.2 -16,-0.2 -0.598 32.4-151.7 -77.6 140.1 -16.6 5.2 6.6 41 52 A T + 0 0 10 -18,-2.0 -18,-0.2 -2,-0.3 6,-0.1 -0.609 60.7 3.8-109.5 172.8 -15.2 8.6 7.4 42 53 A S S S+ 0 0 58 -2,-0.2 -1,-0.2 1,-0.2 5,-0.1 0.709 80.9 130.8 18.1 59.1 -16.7 12.0 8.4 43 54 A N S S+ 0 0 127 4,-0.4 -1,-0.2 -3,-0.2 -2,-0.1 0.654 77.5 30.3-102.1 -25.3 -20.2 10.5 8.6 44 55 A S S S- 0 0 114 3,-0.3 -1,-0.1 2,-0.0 -2,-0.1 -0.311 146.7 -63.5-164.7 67.9 -20.9 11.9 12.1 45 56 A K S S+ 0 0 183 -4,-0.0 2,-0.2 -3,-0.0 -4,-0.1 -0.805 102.6 16.8-149.1 40.0 -19.2 14.1 11.4 46 57 A N S S- 0 0 130 1,-0.5 -3,-0.1 0, 0.0 -2,-0.0 -0.780 91.8 -20.5-172.1 123.4 -15.5 14.3 10.6 47 58 A V S S- 0 0 74 -2,-0.2 -1,-0.5 -5,-0.1 -4,-0.4 0.239 99.4 -41.3 60.9 166.0 -12.8 11.8 9.6 48 59 A P > - 0 0 4 0, 0.0 3,-0.5 0, 0.0 -7,-0.2 -0.381 51.0-128.5 -62.8 138.9 -13.0 8.0 10.3 49 60 A P T 3 S+ 0 0 111 0, 0.0 2,-0.5 0, 0.0 3,-0.1 0.881 107.4 32.6 -54.3 -40.0 -14.5 7.1 13.7 50 61 A D T 3 + 0 0 71 1,-0.1 4,-0.4 2,-0.0 3,-0.4 -0.803 67.3 167.5-122.2 87.6 -11.5 4.8 14.2 51 62 A L X + 0 0 55 -2,-0.5 3,-0.9 -3,-0.5 -1,-0.1 0.756 69.3 73.5 -70.1 -25.8 -8.5 6.4 12.5 52 63 A S G > S+ 0 0 51 1,-0.3 3,-1.6 2,-0.2 62,-0.5 0.911 95.2 48.9 -55.7 -47.2 -6.1 4.0 14.3 53 64 A I G 3 S+ 0 0 24 -3,-0.4 -25,-0.6 1,-0.3 -1,-0.3 0.676 110.4 53.0 -68.8 -16.8 -7.1 1.0 12.2 54 65 A a G < S+ 0 0 0 -3,-0.9 2,-0.4 -4,-0.4 -43,-0.4 0.207 85.8 114.2-101.3 13.8 -6.7 3.2 9.0 55 66 A T < + 0 0 9 -3,-1.6 58,-1.4 -45,-0.1 59,-0.6 -0.740 39.4 168.6 -91.6 130.2 -3.1 4.1 10.0 56 67 A F E -CH 9 112C 0 -47,-3.0 -47,-3.2 -2,-0.4 2,-0.4 -0.920 25.3-138.9-136.8 159.9 -0.3 2.9 7.9 57 68 A V E -CH 8 111C 9 54,-1.3 54,-2.4 -2,-0.3 2,-2.3 -0.985 16.9-134.2-124.1 132.0 3.4 3.6 7.5 58 69 A L E + H 0 110C 0 -51,-2.0 -52,-2.3 -2,-0.4 -51,-0.4 -0.419 38.9 168.0 -79.9 65.7 5.3 3.9 4.2 59 70 A E E + 0 0 29 -2,-2.3 2,-0.3 50,-1.1 -1,-0.2 0.915 58.2 10.0 -44.5 -64.5 8.1 1.6 5.4 60 71 A Q E - H 0 109C 72 49,-0.7 49,-2.1 -3,-0.2 2,-0.1 -0.777 49.8-172.5-122.8 165.4 9.8 1.0 2.1 61 72 A S E + H 0 108C 2 -2,-0.3 2,-0.3 47,-0.3 47,-0.2 -0.612 25.2 157.6-156.9 86.5 9.7 2.3 -1.5 62 73 A L E - H 0 107C 19 45,-2.5 45,-2.9 -2,-0.1 2,-0.1 -0.786 45.1 -99.0-114.2 158.2 11.8 0.3 -3.9 63 74 A S E > - H 0 106C 27 -2,-0.3 4,-3.2 43,-0.3 5,-0.3 -0.426 34.5-117.3 -70.2 148.2 11.7 -0.1 -7.7 64 75 A V H > S+ 0 0 47 41,-0.6 4,-2.7 1,-0.2 5,-0.3 0.915 117.6 50.7 -51.3 -45.1 10.1 -3.3 -8.9 65 76 A R H > S+ 0 0 169 1,-0.2 4,-2.1 2,-0.2 -1,-0.2 0.944 113.1 43.5 -57.8 -52.8 13.4 -4.3 -10.4 66 77 A A H > S+ 0 0 23 2,-0.2 4,-2.6 1,-0.2 -2,-0.2 0.899 114.1 51.1 -61.7 -43.1 15.3 -3.6 -7.2 67 78 A L H X S+ 0 0 3 -4,-3.2 4,-2.3 1,-0.2 -2,-0.2 0.931 112.4 44.9 -61.5 -48.2 12.7 -5.3 -5.0 68 79 A Q H X S+ 0 0 92 -4,-2.7 4,-2.0 -5,-0.3 -1,-0.2 0.850 112.7 53.0 -65.2 -34.3 12.6 -8.5 -7.1 69 80 A E H X S+ 0 0 108 -4,-2.1 4,-2.0 -5,-0.3 -2,-0.2 0.918 108.6 49.5 -65.7 -44.1 16.4 -8.5 -7.2 70 81 A M H X S+ 0 0 96 -4,-2.6 4,-0.8 1,-0.2 -2,-0.2 0.922 113.5 45.2 -60.8 -46.8 16.6 -8.3 -3.5 71 82 A L H < S+ 0 0 39 -4,-2.3 3,-0.3 1,-0.2 -1,-0.2 0.840 111.3 54.1 -66.6 -33.8 14.1 -11.2 -3.0 72 83 A A H >X S+ 0 0 53 -4,-2.0 3,-1.0 1,-0.2 4,-0.7 0.852 106.4 51.5 -68.4 -35.2 15.9 -13.1 -5.7 73 84 A N H 3< S+ 0 0 48 -4,-2.0 -1,-0.2 1,-0.2 -2,-0.2 0.677 104.1 58.8 -75.2 -18.1 19.2 -12.7 -3.9 74 85 A T T 3< S+ 0 0 103 -4,-0.8 -1,-0.2 -3,-0.3 -2,-0.2 0.398 93.0 71.4 -90.8 1.9 17.6 -14.0 -0.7 75 86 A V T <4 S- 0 0 102 -3,-1.0 2,-0.2 1,-0.2 -2,-0.2 0.966 120.7 -11.5 -80.1 -60.5 16.7 -17.3 -2.3 76 87 A E S < S+ 0 0 180 -4,-0.7 2,-0.3 0, 0.0 -1,-0.2 -0.712 97.0 105.3-147.5 90.3 20.1 -19.0 -2.6 77 88 A K - 0 0 110 -2,-0.2 -4,-0.0 -3,-0.1 0, 0.0 -0.848 46.7-156.2-169.0 129.3 23.2 -16.8 -2.0 78 89 A S S S+ 0 0 120 -2,-0.3 2,-0.1 3,-0.0 -1,-0.1 0.782 83.5 65.9 -77.6 -28.4 25.7 -16.6 0.9 79 90 A E + 0 0 162 1,-0.1 -2,-0.0 -6,-0.0 0, 0.0 -0.338 58.4 85.1 -87.8 172.7 26.6 -13.0 -0.1 80 91 A G + 0 0 65 1,-0.2 2,-0.7 -2,-0.1 -1,-0.1 0.747 48.2 155.2 104.5 32.9 24.3 -9.9 0.0 81 92 A Q - 0 0 138 1,-0.1 -1,-0.2 -3,-0.0 3,-0.2 -0.837 24.7-172.8 -97.3 116.4 24.7 -8.8 3.6 82 93 A V S S+ 0 0 88 -2,-0.7 2,-0.7 1,-0.2 11,-0.2 0.742 81.9 56.0 -76.4 -24.5 24.1 -5.1 4.1 83 94 A D + 0 0 52 1,-0.2 -1,-0.2 7,-0.1 4,-0.1 -0.769 58.2 150.6-112.2 86.0 25.3 -5.3 7.7 84 95 A V S S+ 0 0 87 -2,-0.7 3,-0.2 2,-0.2 -1,-0.2 0.761 80.3 39.6 -86.1 -27.0 28.8 -6.7 7.7 85 96 A E S S- 0 0 113 1,-0.7 -1,-0.2 -3,-0.2 2,-0.1 0.883 107.7-145.6 -58.0 -41.4 30.0 -4.9 10.8 86 97 A K S > S+ 0 0 113 -3,-0.1 4,-2.1 0, 0.0 -1,-0.7 -0.935 79.7 35.0 -80.7 -26.1 27.2 -5.9 11.3 87 98 A W H > S+ 0 0 185 2,-0.2 4,-2.4 -3,-0.2 5,-0.2 0.920 121.9 43.8 -52.2 -57.5 26.4 -2.8 13.5 88 99 A K H > S+ 0 0 121 1,-0.2 4,-2.3 2,-0.2 5,-0.2 0.949 116.0 47.0 -57.1 -52.4 28.5 -0.2 11.7 89 100 A F H > S+ 0 0 90 1,-0.2 4,-2.2 2,-0.2 -1,-0.2 0.826 112.1 53.7 -58.9 -30.3 27.5 -1.3 8.2 90 101 A M H X S+ 0 0 93 -4,-2.1 4,-2.3 2,-0.2 -1,-0.2 0.888 107.8 48.0 -71.3 -40.4 23.9 -1.4 9.5 91 102 A M H X S+ 0 0 135 -4,-2.4 4,-2.3 2,-0.2 -2,-0.2 0.860 113.4 48.6 -68.3 -35.7 24.1 2.2 10.7 92 103 A K H X S+ 0 0 150 -4,-2.3 4,-1.8 -5,-0.2 -2,-0.2 0.917 113.4 45.8 -69.7 -44.6 25.6 3.3 7.4 93 104 A T H X S+ 0 0 59 -4,-2.2 4,-2.1 -11,-0.2 -2,-0.2 0.876 115.0 48.0 -65.9 -38.4 22.9 1.5 5.4 94 105 A A H < S+ 0 0 65 -4,-2.3 4,-0.4 2,-0.2 -2,-0.2 0.918 116.9 41.0 -68.7 -44.9 20.1 2.9 7.6 95 106 A Q H < S+ 0 0 166 -4,-2.3 -2,-0.2 1,-0.2 -1,-0.2 0.739 117.5 50.7 -74.8 -23.2 21.4 6.4 7.5 96 107 A G H < S+ 0 0 61 -4,-1.8 -2,-0.2 -5,-0.2 -1,-0.2 0.819 107.4 54.4 -83.4 -33.1 22.2 6.1 3.8 97 108 A G S < S+ 0 0 31 -4,-2.1 2,-0.3 -5,-0.1 -3,-0.1 0.927 93.4 83.0 -64.2 -98.3 18.8 4.7 2.8 98 109 A G + 0 0 21 -4,-0.4 2,-0.3 -5,-0.1 -1,-0.1 -0.920 48.5 39.9 159.9 177.3 16.0 7.0 3.9 99 110 A H S S+ 0 0 156 -2,-0.3 2,-0.3 -94,-0.2 -93,-0.1 -0.512 75.1 176.3 56.0 70.3 13.8 8.9 4.5 100 111 A R - 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