==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-SEP-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER TRANSFERASE 30-AUG-13 4MI0 . COMPND 2 MOLECULE: HISTONE-LYSINE N-METHYLTRANSFERASE EZH2; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR A.DONG,H.ZENG,H.HE,A.WERNIMONT,C.BOUNTRA,C.H.ARROWSMITH,A.M. . 208 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 12014.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 105 50.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 9 4.3 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 33 15.9 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 13 6.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 20 9.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 15 7.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 3 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 3 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 2 0 2 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 520 A Y 0 0 95 0, 0.0 185,-0.0 0, 0.0 23,-0.0 0.000 360.0 360.0 360.0 165.6 25.8 25.1 9.4 2 521 A Q - 0 0 153 14,-0.1 2,-0.1 15,-0.0 23,-0.1 -0.729 360.0-139.8 -82.9 106.3 28.8 22.6 9.0 3 522 A P - 0 0 72 0, 0.0 2,-0.2 0, 0.0 25,-0.1 -0.436 14.6-126.0 -71.5 142.7 29.6 22.2 5.2 4 523 A C - 0 0 2 21,-0.1 25,-3.1 -2,-0.1 26,-0.2 -0.501 25.6-179.6 -86.0 156.0 30.5 18.7 3.9 5 524 A D + 0 0 112 23,-0.2 23,-0.0 -2,-0.2 25,-0.0 -0.709 21.4 143.5-158.7 94.6 33.6 18.0 1.9 6 525 A H > - 0 0 32 3,-0.2 3,-1.7 -2,-0.2 -2,-0.0 -0.746 44.3-138.6-138.0 79.1 34.2 14.4 0.8 7 526 A P T 3 S+ 0 0 103 0, 0.0 23,-0.1 0, 0.0 -2,-0.1 -0.159 79.2 2.5 -49.6 133.4 35.9 14.6 -2.7 8 527 A R T 3 S+ 0 0 115 1,-0.2 22,-0.0 0, 0.0 0, 0.0 0.608 110.2 103.2 63.6 21.8 34.7 12.2 -5.4 9 528 A Q < - 0 0 113 -3,-1.7 -3,-0.2 3,-0.0 -1,-0.2 -0.985 68.9-125.8-129.0 140.8 32.0 10.7 -3.1 10 529 A P - 0 0 92 0, 0.0 2,-1.6 0, 0.0 4,-0.1 -0.175 36.4 -93.1 -75.4 176.1 28.3 11.5 -3.2 11 530 A C S S+ 0 0 25 3,-0.1 2,-0.1 2,-0.1 24,-0.1 -0.696 76.9 136.0 -90.4 80.3 26.2 12.7 -0.2 12 531 A D S > S- 0 0 69 -2,-1.6 3,-2.1 24,-0.0 6,-0.3 -0.182 74.1 -50.0-105.0-153.5 25.1 9.3 0.9 13 532 A S T 3 S+ 0 0 105 1,-0.3 -2,-0.1 5,-0.1 0, 0.0 0.580 135.2 54.1 -58.0 -19.1 24.9 7.5 4.4 14 533 A S T 3 S+ 0 0 91 -4,-0.1 -1,-0.3 4,-0.0 -3,-0.1 0.430 83.2 102.1 -96.7 -5.8 28.5 8.5 5.1 15 534 A C S <> S- 0 0 1 -3,-2.1 4,-2.6 1,-0.1 3,-0.4 -0.702 70.5-139.6 -81.0 128.2 28.0 12.3 4.5 16 535 A P H > S+ 0 0 52 0, 0.0 4,-2.2 0, 0.0 -1,-0.1 0.770 102.9 56.6 -60.6 -25.8 27.6 14.3 7.8 17 536 A C H 4>S+ 0 0 10 2,-0.2 5,-2.9 1,-0.1 4,-0.3 0.924 111.5 41.9 -66.7 -45.1 24.8 16.5 6.3 18 537 A V H >45S+ 0 0 47 -3,-0.4 3,-1.0 -6,-0.3 -1,-0.1 0.914 116.2 49.4 -65.9 -48.5 22.7 13.3 5.5 19 538 A I H 3<5S+ 0 0 109 -4,-2.6 -2,-0.2 -7,-0.2 -1,-0.2 0.896 113.2 45.8 -58.2 -45.4 23.6 11.7 8.9 20 539 A A T 3<5S- 0 0 60 -4,-2.2 -1,-0.2 -5,-0.2 -2,-0.2 0.475 113.7-121.7 -81.2 1.5 22.6 14.9 10.8 21 540 A Q T < 5 + 0 0 177 -3,-1.0 2,-0.3 -4,-0.3 -3,-0.2 0.883 67.9 128.8 59.8 46.7 19.4 15.2 8.7 22 541 A N < - 0 0 95 -5,-2.9 -1,-0.2 -6,-0.1 2,-0.2 -0.893 61.8-104.3-124.2 158.2 20.2 18.6 7.3 23 542 A F - 0 0 85 -2,-0.3 14,-0.2 1,-0.1 2,-0.1 -0.520 37.1-108.4 -76.8 151.3 20.2 20.0 3.7 24 543 A C B -a 37 0A 1 12,-2.0 14,-0.8 -2,-0.2 2,-0.2 -0.478 44.1-149.7 -69.9 144.2 23.5 20.5 2.0 25 544 A E > - 0 0 31 -2,-0.1 3,-2.6 12,-0.1 -21,-0.1 -0.694 30.4 -80.7-116.5 174.8 24.1 24.3 1.8 26 545 A K T 3 S+ 0 0 66 1,-0.3 159,-0.1 -2,-0.2 -2,-0.0 0.787 127.1 47.2 -39.6 -48.8 25.8 26.8 -0.6 27 546 A F T 3 S+ 0 0 57 157,-0.2 -1,-0.3 2,-0.0 -3,-0.0 0.488 82.3 114.5 -83.0 -2.4 29.3 26.1 0.9 28 547 A C < - 0 0 6 -3,-2.6 -23,-0.2 1,-0.1 -4,-0.0 -0.340 67.6-135.0 -63.3 149.5 29.1 22.2 0.9 29 548 A Q + 0 0 130 -25,-3.1 -24,-0.1 3,-0.0 -1,-0.1 0.357 69.7 106.8 -94.0 7.9 31.7 20.8 -1.5 30 549 A C S S- 0 0 21 -26,-0.2 4,-0.0 1,-0.2 -26,-0.0 -0.229 83.7 -67.7 -74.5 171.3 29.3 18.3 -3.1 31 550 A S > - 0 0 73 1,-0.1 3,-2.1 2,-0.1 -1,-0.2 -0.193 37.0-119.2 -57.8 153.2 27.9 18.7 -6.7 32 551 A S T 3 S+ 0 0 111 1,-0.3 -1,-0.1 -3,-0.1 -2,-0.1 0.722 119.5 56.1 -64.3 -22.9 25.4 21.5 -7.5 33 552 A E T 3 S+ 0 0 172 3,-0.0 -1,-0.3 2,-0.0 -2,-0.1 0.238 76.7 144.0 -94.1 7.7 23.1 18.6 -8.4 34 553 A C X - 0 0 20 -3,-2.1 3,-1.6 1,-0.2 -10,-0.1 -0.314 49.8-142.1 -52.6 128.8 23.5 17.0 -4.9 35 554 A Q T 3 S+ 0 0 132 1,-0.3 -1,-0.2 -24,-0.1 -3,-0.0 0.630 98.9 63.2 -67.6 -20.0 20.1 15.4 -4.1 36 555 A N T 3 S+ 0 0 37 2,-0.1 -12,-2.0 -13,-0.1 -1,-0.3 0.423 83.4 101.4 -86.9 -0.2 20.6 16.5 -0.4 37 556 A R B < S-a 24 0A 51 -3,-1.6 -12,-0.1 -14,-0.2 -5,-0.0 -0.470 89.7 -91.5 -79.8 156.9 20.5 20.3 -1.5 38 557 A F - 0 0 20 -14,-0.8 -1,-0.1 1,-0.1 -2,-0.1 -0.497 30.4-146.4 -70.1 128.1 17.4 22.4 -0.9 39 558 A P - 0 0 97 0, 0.0 -1,-0.1 0, 0.0 2,-0.1 0.638 27.8-143.5 -72.4 -13.2 15.2 22.3 -4.2 40 559 A G - 0 0 6 26,-0.1 2,-0.3 13,-0.1 26,-0.1 -0.450 28.1 -75.4 78.9-160.3 13.9 25.9 -3.8 41 560 A C - 0 0 6 21,-0.2 27,-0.4 -2,-0.1 26,-0.4 -0.872 15.0-153.5-133.5 169.8 10.3 26.6 -4.9 42 561 A R + 0 0 146 -2,-0.3 2,-0.1 24,-0.1 24,-0.1 -0.244 42.7 155.5-135.3 39.1 8.2 27.1 -8.0 43 562 A C - 0 0 25 1,-0.1 3,-0.1 4,-0.0 -2,-0.1 -0.332 51.3-126.9 -64.7 154.1 5.5 29.4 -6.4 44 563 A K S S- 0 0 126 1,-0.2 2,-0.2 -2,-0.1 -1,-0.1 0.875 77.1 -55.3 -66.0 -42.3 3.4 31.8 -8.6 45 564 A A S S+ 0 0 35 25,-0.0 2,-1.8 35,-0.0 -1,-0.2 -0.910 110.1 58.8-179.1-174.1 4.4 34.8 -6.3 46 565 A Q B -b 82 0B 69 35,-3.6 37,-2.2 23,-0.3 23,-0.0 -0.474 50.7-168.1 70.9 -68.7 4.3 35.9 -2.6 47 566 A C + 0 0 4 -2,-1.8 -1,-0.2 35,-0.2 14,-0.1 0.855 53.5 115.1 54.1 36.2 6.4 32.9 -1.0 48 567 A N + 0 0 77 -3,-0.2 2,-0.3 6,-0.0 -1,-0.1 0.023 58.6 61.6-129.0 27.2 5.1 34.3 2.5 49 568 A T S > S- 0 0 71 0, 0.0 3,-2.3 0, 0.0 7,-0.3 -0.900 97.0 -94.6-144.7 165.1 3.0 31.4 3.7 50 569 A K T 3 S+ 0 0 52 1,-0.3 6,-0.1 -2,-0.3 7,-0.0 0.541 114.8 77.7 -65.1 -6.0 3.6 27.6 4.6 51 570 A Q T 3 S+ 0 0 161 4,-0.0 -1,-0.3 1,-0.0 3,-0.1 0.675 81.7 80.3 -74.6 -17.9 2.5 26.8 1.0 52 571 A C S <> S- 0 0 1 -3,-2.3 4,-2.8 1,-0.1 5,-0.2 -0.825 74.3-152.3 -90.0 119.1 6.0 28.0 0.0 53 572 A P H > S+ 0 0 60 0, 0.0 4,-1.9 0, 0.0 -1,-0.1 0.861 97.5 51.9 -56.0 -36.9 8.7 25.3 0.6 54 573 A C H 4>S+ 0 0 2 2,-0.2 5,-1.7 1,-0.2 3,-0.3 0.981 112.3 43.8 -65.0 -52.1 11.3 28.0 1.2 55 574 A Y H >45S+ 0 0 35 1,-0.2 3,-1.5 -6,-0.2 -1,-0.2 0.885 112.5 53.0 -57.3 -45.0 9.2 29.9 3.7 56 575 A L H 3<5S+ 0 0 117 -4,-2.8 -1,-0.2 -7,-0.3 -2,-0.2 0.886 109.0 49.5 -60.0 -37.5 8.3 26.6 5.5 57 576 A A T 3<5S- 0 0 42 -4,-1.9 -1,-0.3 -3,-0.3 -2,-0.2 0.275 118.6-113.0 -85.6 8.5 12.0 25.7 5.8 58 577 A V T < 5S+ 0 0 51 -3,-1.5 123,-1.8 1,-0.2 2,-0.3 0.945 76.5 128.0 57.4 51.8 12.8 29.2 7.3 59 578 A R B < -c 181 0C 31 -5,-1.7 -1,-0.2 121,-0.2 123,-0.2 -0.990 60.2-125.2-132.8 144.1 14.8 30.2 4.2 60 579 A E - 0 0 10 121,-2.7 123,-0.2 -2,-0.3 25,-0.2 -0.477 46.9 -89.0 -79.0 161.0 14.6 33.2 1.9 61 580 A C - 0 0 0 23,-2.1 122,-0.2 -2,-0.1 -1,-0.1 -0.314 39.3-131.0 -67.0 152.2 14.2 32.3 -1.8 62 581 A D >> - 0 0 45 1,-0.1 4,-3.2 120,-0.1 3,-1.1 -0.956 2.3-142.6-110.3 126.8 17.4 31.9 -3.8 63 582 A P T 34 S+ 0 0 41 0, 0.0 9,-0.1 0, 0.0 -1,-0.1 0.795 103.4 48.6 -60.7 -26.2 17.7 33.8 -7.1 64 583 A D T 34 S+ 0 0 77 1,-0.1 3,-0.1 7,-0.1 -3,-0.0 0.593 125.3 27.2 -86.3 -15.7 19.6 30.8 -8.7 65 584 A L T <4 S+ 0 0 68 -3,-1.1 2,-1.2 1,-0.2 -1,-0.1 0.692 108.4 65.3-114.7 -37.9 17.0 28.2 -7.5 66 585 A C < + 0 0 1 -4,-3.2 6,-0.6 1,-0.2 5,-0.3 -0.772 62.4 162.0 -94.3 81.1 13.6 29.9 -7.2 67 586 A L + 0 0 105 -2,-1.2 -1,-0.2 -26,-0.4 -25,-0.1 0.412 64.3 35.7 -84.3 -7.2 13.3 30.7 -10.9 68 587 A T S S+ 0 0 75 -27,-0.4 -1,-0.1 -3,-0.1 -26,-0.1 0.702 96.4 70.3-121.8 -28.9 9.5 31.4 -11.1 69 588 A C S S- 0 0 1 -28,-0.2 -23,-0.3 -24,-0.1 -2,-0.1 0.627 113.1 -96.7 -64.9 -24.5 8.2 33.2 -8.0 70 589 A G S > S+ 0 0 3 -4,-0.3 3,-0.8 11,-0.2 12,-0.3 0.339 91.9 121.5 115.6 2.5 10.0 36.5 -8.9 71 590 A A T 3 S+ 0 0 0 -5,-0.3 -4,-0.1 1,-0.2 -7,-0.1 0.846 75.1 53.8 -62.6 -34.8 13.1 35.9 -6.7 72 591 A A T 3 S+ 0 0 31 -6,-0.6 2,-1.9 1,-0.2 -1,-0.2 0.647 85.6 84.2 -74.8 -16.9 15.4 36.1 -9.8 73 592 A D X + 0 0 66 -3,-0.8 3,-1.5 1,-0.2 -1,-0.2 -0.406 53.4 154.4 -84.7 59.8 13.9 39.6 -10.8 74 593 A H T 3 + 0 0 129 -2,-1.9 -1,-0.2 1,-0.3 -2,-0.1 0.625 60.6 67.3 -66.3 -18.6 16.4 41.3 -8.4 75 594 A W T 3 S+ 0 0 182 -3,-0.2 2,-0.3 2,-0.0 -1,-0.3 0.646 84.2 89.2 -75.4 -21.1 16.3 44.6 -10.4 76 595 A D < + 0 0 52 -3,-1.5 3,-0.0 1,-0.1 4,-0.0 -0.662 41.3 163.3 -82.7 135.9 12.6 45.1 -9.3 77 596 A S + 0 0 119 -2,-0.3 2,-0.4 1,-0.1 3,-0.3 0.504 50.0 85.3-125.2 -16.6 12.0 47.0 -6.1 78 597 A K S S- 0 0 66 1,-0.2 3,-0.1 0, 0.0 -1,-0.1 -0.831 110.0 -20.0-101.1 130.6 8.3 48.0 -6.4 79 598 A N S S- 0 0 159 -2,-0.4 -1,-0.2 1,-0.1 4,-0.1 0.866 88.3-151.7 42.1 50.0 5.3 45.7 -5.3 80 599 A V - 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