==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=22-JAN-2012 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER INHIBITOR 08-MAY-03 1OGQ . COMPND 2 MOLECULE: POLYGALACTURONASE INHIBITING PROTEIN; . SOURCE 2 ORGANISM_SCIENTIFIC: PHASEOLUS VULGARIS; . AUTHOR A.DI MATTEO,L.FEDERICI,B.MATTEI,G.SALVI,K.A.JOHNSON, . 313 1 4 4 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 13617.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 199 63.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 69 22.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 5 1.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 16 5.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 54 17.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 13 4.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 3 11 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 3 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 1 A E 0 0 141 0, 0.0 30,-0.0 0, 0.0 32,-0.0 0.000 360.0 360.0 360.0 138.0 68.2 60.3 35.4 2 2 A L + 0 0 78 2,-0.1 30,-0.0 3,-0.0 0, 0.0 0.862 360.0 103.3 -74.4 -34.5 68.8 57.5 32.9 3 3 A a S S- 0 0 2 1,-0.1 48,-0.1 2,-0.1 47,-0.0 -0.144 80.9-115.1 -50.9 127.4 65.2 57.1 31.8 4 4 A N > - 0 0 39 46,-0.5 4,-2.7 1,-0.2 5,-0.2 -0.446 18.2-130.5 -67.5 131.8 64.6 58.8 28.4 5 5 A P H > S+ 0 0 79 0, 0.0 4,-2.0 0, 0.0 -1,-0.2 0.860 106.1 47.5 -53.1 -36.1 62.2 61.7 28.8 6 6 A Q H > S+ 0 0 124 2,-0.2 4,-2.0 1,-0.2 5,-0.2 0.930 112.1 48.2 -77.5 -35.4 60.0 60.5 25.9 7 7 A D H > S+ 0 0 0 2,-0.2 4,-2.6 1,-0.2 5,-0.2 0.916 110.7 54.4 -64.5 -42.5 59.8 56.9 27.1 8 8 A K H X S+ 0 0 21 -4,-2.7 4,-2.5 1,-0.2 5,-0.2 0.955 109.6 45.1 -55.9 -48.7 58.9 58.3 30.6 9 9 A Q H X S+ 0 0 109 -4,-2.0 4,-2.0 -5,-0.2 -1,-0.2 0.893 112.4 51.4 -69.2 -33.7 56.0 60.3 29.3 10 10 A A H X S+ 0 0 6 -4,-2.0 4,-2.8 64,-0.2 -1,-0.2 0.906 111.0 48.0 -67.1 -42.8 54.7 57.5 27.2 11 11 A L H X S+ 0 0 0 -4,-2.6 4,-2.3 2,-0.2 -2,-0.2 0.941 112.4 48.0 -62.5 -47.9 54.8 55.0 30.1 12 12 A L H X S+ 0 0 22 -4,-2.5 4,-2.2 -5,-0.2 -2,-0.2 0.880 112.8 50.7 -63.0 -29.5 53.0 57.5 32.4 13 13 A Q H X S+ 0 0 89 -4,-2.0 4,-3.4 -5,-0.2 -2,-0.2 0.923 107.3 51.8 -70.4 -40.6 50.5 58.1 29.6 14 14 A I H X S+ 0 0 0 -4,-2.8 4,-0.9 1,-0.2 -2,-0.2 0.949 110.6 50.0 -57.7 -48.1 49.9 54.3 29.2 15 15 A K H ><>S+ 0 0 29 -4,-2.3 5,-2.2 2,-0.2 3,-0.8 0.940 113.2 44.6 -55.1 -50.6 49.3 54.2 32.9 16 16 A K H ><5S+ 0 0 130 -4,-2.2 3,-2.1 1,-0.2 -2,-0.2 0.902 109.1 57.3 -62.7 -40.6 46.8 57.1 32.8 17 17 A D H 3<5S+ 0 0 55 -4,-3.4 -1,-0.2 1,-0.3 -2,-0.2 0.684 105.4 51.7 -66.2 -13.1 45.1 55.6 29.7 18 18 A L T <<5S- 0 0 4 -4,-0.9 -1,-0.3 -3,-0.8 -2,-0.2 0.263 129.9 -95.7-107.8 12.5 44.5 52.4 31.8 19 19 A G T < 5 - 0 0 25 -3,-2.1 -3,-0.2 1,-0.2 -2,-0.2 0.776 59.4 -80.8 85.6 25.4 42.9 54.4 34.6 20 20 A N < - 0 0 83 -5,-2.2 -1,-0.2 -6,-0.2 -4,-0.2 0.891 64.7-155.4 44.6 57.8 46.0 54.7 36.8 21 21 A P > - 0 0 6 0, 0.0 3,-2.0 0, 0.0 -1,-0.1 -0.242 22.2-121.6 -62.3 148.7 45.5 51.2 38.2 22 22 A T G > S+ 0 0 118 1,-0.3 3,-2.3 39,-0.2 4,-0.2 0.852 110.3 69.8 -60.9 -29.2 47.0 50.4 41.6 23 23 A T G 3 S+ 0 0 52 37,-0.5 -1,-0.3 1,-0.3 3,-0.2 0.654 101.3 46.8 -63.0 -14.7 49.0 47.6 39.9 24 24 A L G X S+ 0 0 2 -3,-2.0 3,-2.1 1,-0.1 -1,-0.3 0.192 75.3 113.8-113.0 25.1 51.1 50.3 38.2 25 25 A S T < + 0 0 65 -3,-2.3 -1,-0.1 1,-0.3 -2,-0.1 0.657 65.0 69.4 -72.8 -10.5 51.7 52.4 41.3 26 26 A S T 3 S+ 0 0 36 -3,-0.2 2,-1.7 -4,-0.2 -1,-0.3 0.530 73.7 95.1 -74.5 -12.4 55.4 51.7 41.1 27 27 A W < + 0 0 1 -3,-2.1 -1,-0.1 11,-0.1 11,-0.1 -0.660 62.3 168.8 -83.0 86.8 55.6 53.9 37.9 28 28 A L > - 0 0 72 -2,-1.7 3,-2.5 1,-0.1 5,-0.1 -0.861 44.4-141.4-106.4 130.0 56.6 57.0 39.8 29 29 A P T 3 S+ 0 0 78 0, 0.0 -1,-0.1 0, 0.0 4,-0.1 0.843 103.6 61.2 -55.0 -27.7 57.8 60.3 38.3 30 30 A T T 3 S+ 0 0 124 2,-0.1 2,-0.3 -3,-0.0 -3,-0.0 0.396 99.2 62.5 -80.4 -1.1 60.2 60.6 41.2 31 31 A T S < S- 0 0 40 -3,-2.5 2,-0.6 -5,-0.0 0, 0.0 -0.931 92.2-100.1-126.9 157.2 62.1 57.3 40.4 32 32 A D > > - 0 0 31 -2,-0.3 3,-2.4 1,-0.1 5,-0.5 -0.650 20.4-148.9 -81.0 120.7 64.1 56.3 37.3 33 33 A a T 3 5S+ 0 0 0 -2,-0.6 3,-0.4 1,-0.3 5,-0.3 0.692 96.7 56.0 -57.9 -20.7 62.2 54.1 34.9 34 34 A b T 3 5S+ 0 0 3 1,-0.2 9,-0.3 8,-0.1 -1,-0.3 0.501 86.8 79.4 -90.7 -5.6 65.4 52.4 33.9 35 35 A N T < 5S- 0 0 76 -3,-2.4 -1,-0.2 7,-0.1 -2,-0.1 0.273 105.1-106.9 -98.5 28.1 66.5 51.3 37.4 36 36 A R T 5S+ 0 0 162 -3,-0.4 4,-0.1 5,-0.3 -3,-0.1 0.547 95.1 100.7 71.4 17.2 64.2 48.2 37.8 37 37 A T < + 0 0 82 -5,-0.5 2,-0.8 2,-0.1 -4,-0.1 0.586 57.8 88.5-102.5 -16.5 61.7 49.6 40.3 38 38 A W S > S- 0 0 2 -6,-0.3 3,-2.1 -5,-0.3 -11,-0.1 -0.783 93.4-113.2 -81.9 116.3 59.0 50.3 37.6 39 39 A L T 3 S- 0 0 107 -2,-0.8 -2,-0.1 1,-0.3 17,-0.1 -0.250 92.6 -0.0 -53.0 127.5 57.1 47.0 37.5 40 40 A G T 3 S+ 0 0 23 1,-0.2 16,-2.3 -4,-0.1 2,-0.5 0.512 104.4 117.6 77.4 6.7 57.5 45.3 34.1 41 41 A V E < +A 55 0A 3 -3,-2.1 2,-0.3 14,-0.2 -5,-0.3 -0.934 32.4 167.1-116.5 131.2 59.8 48.0 32.6 42 42 A L E -A 54 0A 78 12,-2.1 11,-1.6 -2,-0.5 12,-1.5 -0.973 22.5-138.7-139.1 149.9 63.4 47.5 31.5 43 43 A b E -A 52 0A 14 -9,-0.3 2,-1.5 -2,-0.3 9,-0.2 -0.681 34.1 -96.7-107.0 155.1 65.8 49.6 29.4 44 44 A D + 0 0 12 7,-2.6 6,-2.3 -2,-0.3 5,-0.4 -0.605 51.2 156.7 -79.2 94.8 68.2 48.5 26.8 45 45 A T + 0 0 77 -2,-1.5 3,-0.2 3,-0.2 -1,-0.2 0.834 69.0 63.1 -81.2 -35.7 71.5 48.1 28.5 46 46 A D S S+ 0 0 155 -3,-0.2 -1,-0.1 1,-0.2 -2,-0.1 0.909 114.3 28.2 -56.5 -53.9 72.9 45.7 25.9 47 47 A T S S- 0 0 89 1,-0.0 -1,-0.2 0, 0.0 -2,-0.1 0.486 104.8-128.5 -88.5 -7.6 72.8 48.0 22.9 48 48 A Q S S+ 0 0 131 -3,-0.2 -3,-0.2 -4,-0.2 -2,-0.1 0.697 77.2 119.4 61.4 33.1 73.3 51.1 25.1 49 49 A T - 0 0 57 -5,-0.4 -4,-0.1 2,-0.1 -1,-0.1 0.759 61.8-152.7 -78.2 -31.2 70.4 53.1 23.7 50 50 A Y + 0 0 82 -6,-2.3 -46,-0.5 1,-0.2 2,-0.2 0.751 46.6 138.6 60.6 25.0 69.2 52.9 27.3 51 51 A R - 0 0 36 -7,-0.3 -7,-2.6 -48,-0.1 2,-0.4 -0.638 69.2 -88.8 -94.5 156.6 65.6 53.2 25.8 52 52 A V E +A 43 0A 0 -9,-0.2 25,-0.4 -2,-0.2 -9,-0.3 -0.526 58.3 156.7 -63.9 116.2 62.7 51.2 27.1 53 53 A N E + 0 0 25 -11,-1.6 26,-2.8 -2,-0.4 27,-1.8 0.409 56.1 53.3-126.9 3.5 62.8 48.0 25.1 54 54 A N E +Ab 42 80A 46 -12,-1.5 -12,-2.1 24,-0.2 2,-0.4 -0.982 57.2 171.0-144.3 114.5 61.0 45.5 27.3 55 55 A L E -Ab 41 81A 0 25,-2.3 27,-2.6 -2,-0.4 2,-0.5 -0.991 7.3-175.6-127.2 130.1 57.5 46.1 28.7 56 56 A D E - b 0 82A 65 -16,-2.3 2,-0.6 -2,-0.4 27,-0.2 -0.986 2.0-179.2-125.5 118.2 55.4 43.4 30.5 57 57 A L E + b 0 83A 5 25,-3.2 27,-2.5 -2,-0.5 2,-0.4 -0.964 20.9 161.9-114.2 110.8 51.8 44.3 31.5 58 58 A S E - b 0 84A 64 -2,-0.6 27,-0.2 25,-0.2 28,-0.1 -0.991 53.8 -9.2-140.6 135.4 50.3 41.4 33.3 59 59 A G + 0 0 43 25,-1.8 27,-0.2 -2,-0.4 -1,-0.1 0.842 69.0 162.2 59.2 39.4 47.3 40.7 35.6 60 60 A L - 0 0 5 24,-0.2 -37,-0.5 -3,-0.1 -1,-0.1 0.614 36.1-143.0 -72.8 -15.1 46.6 44.5 36.1 61 61 A N - 0 0 143 24,-0.3 -39,-0.2 1,-0.1 -38,-0.1 0.970 21.0-153.2 52.9 59.9 43.0 44.1 37.4 62 62 A L - 0 0 4 1,-0.1 -1,-0.1 -41,-0.1 -43,-0.1 -0.456 16.2-126.9 -66.6 143.9 41.7 47.3 35.7 63 63 A P S S- 0 0 95 0, 0.0 -1,-0.1 0, 0.0 -44,-0.1 0.597 87.0 -7.1 -68.5 -12.7 38.7 49.0 37.4 64 64 A K S S- 0 0 108 -46,-0.2 2,-0.1 24,-0.1 24,-0.1 -0.911 100.7 -59.1-168.4 169.8 36.6 48.9 34.2 65 65 A P + 0 0 60 0, 0.0 24,-0.2 0, 0.0 23,-0.1 -0.417 54.1 171.3 -62.8 141.8 37.2 48.0 30.6 66 66 A Y E -k 89 0B 51 22,-2.0 24,-2.3 -2,-0.1 2,-0.1 -0.982 27.1-123.4-143.3 148.1 39.9 50.0 28.7 67 67 A P E -k 90 0B 72 0, 0.0 24,-0.2 0, 0.0 26,-0.1 -0.409 47.9 -75.3 -82.6 174.7 41.3 49.5 25.2 68 68 A I - 0 0 9 22,-0.7 2,-0.1 24,-0.5 -50,-0.0 -0.457 63.3-113.4 -67.0 119.8 45.0 49.0 24.4 69 69 A P > - 0 0 10 0, 0.0 3,-1.6 0, 0.0 4,-0.2 -0.383 9.8-139.8 -59.6 134.1 46.3 52.6 24.8 70 70 A S G > S+ 0 0 83 1,-0.3 3,-1.6 2,-0.2 4,-0.1 0.718 95.9 80.4 -72.3 -8.1 47.5 54.2 21.6 71 71 A S G > S+ 0 0 7 1,-0.3 3,-1.9 2,-0.2 -1,-0.3 0.685 70.7 80.9 -68.6 -8.5 50.4 55.7 23.7 72 72 A L G X S+ 0 0 1 -3,-1.6 3,-1.6 1,-0.3 -1,-0.3 0.886 80.4 66.9 -65.0 -24.1 52.1 52.3 23.4 73 73 A A G < S+ 0 0 9 -3,-1.6 -1,-0.3 1,-0.3 -2,-0.2 0.698 86.9 70.1 -71.9 -12.4 53.2 53.5 20.0 74 74 A N G < S+ 0 0 87 -3,-1.9 -1,-0.3 1,-0.2 -64,-0.2 0.232 79.9 75.7 -96.1 26.2 55.4 56.1 21.8 75 75 A L X + 0 0 0 -3,-1.6 3,-2.0 1,-0.1 -1,-0.2 -0.642 61.7 170.0-126.3 71.3 57.9 53.4 23.1 76 76 A P T 3 + 0 0 40 0, 0.0 26,-0.4 0, 0.0 25,-0.2 0.583 65.4 60.8 -67.1 -10.8 59.6 53.0 19.7 77 77 A Y T 3 S+ 0 0 98 -25,-0.4 -26,-0.1 24,-0.1 23,-0.1 0.341 70.8 136.9 -98.3 5.0 62.5 50.9 20.9 78 78 A L < + 0 0 0 -3,-2.0 24,-0.4 1,-0.2 -24,-0.2 -0.274 17.7 164.3 -54.8 127.0 60.3 48.0 22.2 79 79 A N S S+ 0 0 39 -26,-2.8 25,-2.7 1,-0.3 26,-2.4 0.552 73.4 37.0-104.4 -34.3 61.8 44.6 21.3 80 80 A F E +bc 54 105A 48 -27,-1.8 -25,-2.3 24,-0.2 2,-0.4 -0.985 64.1 171.7-125.7 120.7 59.6 42.6 23.8 81 81 A L E +bc 55 106A 0 24,-2.5 26,-2.6 -2,-0.4 2,-0.5 -0.954 3.3 178.5-133.5 112.6 56.0 43.5 24.5 82 82 A Y E +bc 56 107A 61 -27,-2.6 -25,-3.2 -2,-0.4 2,-0.5 -0.969 4.9 171.5-115.1 123.5 53.9 41.2 26.7 83 83 A I E +bc 57 108A 4 24,-2.2 26,-2.4 -2,-0.5 2,-0.3 -0.985 28.1 142.7-128.2 105.0 50.2 42.2 27.5 84 84 A G E +bc 58 109A 0 -27,-2.5 -25,-1.8 -2,-0.5 26,-0.2 -0.997 38.1 26.7-156.2 151.4 48.5 39.3 29.2 85 85 A G E S+ 0 0 39 24,-1.7 2,-0.5 -2,-0.3 -24,-0.3 0.897 70.8 137.7 74.4 37.0 46.0 38.1 31.7 86 86 A I E > - c 0 111A 3 24,-1.2 3,-1.6 23,-0.4 26,-0.7 -0.879 33.1-171.6-121.4 96.0 43.9 41.3 31.8 87 87 A N T 3 S+ 0 0 125 -2,-0.5 -1,-0.1 1,-0.3 24,-0.1 0.836 84.6 50.0 -55.6 -39.0 40.2 40.5 31.9 88 88 A N T 3 S+ 0 0 46 -24,-0.1 -22,-2.0 23,-0.1 2,-0.6 0.154 79.1 110.3 -89.6 14.0 39.1 44.2 31.3 89 89 A L E < +k 66 0B 4 -3,-1.6 23,-1.8 -24,-0.2 2,-0.2 -0.841 47.4 163.2 -89.7 117.9 41.4 44.9 28.3 90 90 A V E +k 67 0B 48 -24,-2.3 -22,-0.7 -2,-0.6 23,-0.2 -0.567 19.8 58.5-124.0-175.8 39.0 45.3 25.3 91 91 A G S S- 0 0 17 21,-0.5 23,-2.5 -2,-0.2 2,-0.0 -0.143 82.0 -49.0 81.1 176.4 39.0 46.7 21.8 92 92 A P - 0 0 78 0, 0.0 -24,-0.5 0, 0.0 23,-0.2 -0.285 55.9 -93.5 -82.6 174.2 41.1 45.8 18.8 93 93 A I - 0 0 8 23,-0.4 23,-0.1 21,-0.4 -2,-0.1 -0.827 57.4-132.8 -86.2 111.0 44.9 45.5 18.3 94 94 A P > - 0 0 20 0, 0.0 3,-2.4 0, 0.0 4,-0.3 -0.432 12.6-121.9 -75.7 150.6 45.4 49.1 17.1 95 95 A P G > S+ 0 0 98 0, 0.0 3,-1.6 0, 0.0 4,-0.4 0.678 104.4 86.2 -62.1 -9.4 47.5 50.1 14.1 96 96 A A G > S+ 0 0 22 1,-0.3 3,-1.6 2,-0.2 4,-0.2 0.848 77.1 65.8 -54.3 -33.4 49.5 52.1 16.7 97 97 A I G X S+ 0 0 0 -3,-2.4 3,-2.3 1,-0.3 -1,-0.3 0.824 84.4 73.0 -66.6 -22.4 51.5 48.8 17.2 98 98 A A G < S+ 0 0 17 -3,-1.6 -1,-0.3 -4,-0.3 -2,-0.2 0.830 85.4 66.1 -63.7 -20.2 52.8 49.2 13.6 99 99 A K G < S+ 0 0 109 -3,-1.6 2,-1.8 -4,-0.4 -1,-0.3 0.643 78.0 86.9 -73.2 -13.2 54.9 52.1 15.0 100 100 A L X + 0 0 0 -3,-2.3 3,-1.5 -4,-0.2 -1,-0.2 -0.524 55.5 167.2 -89.5 73.5 56.9 49.5 17.1 101 101 A T T 3 + 0 0 80 -2,-1.8 25,-0.4 1,-0.3 -1,-0.2 0.477 66.7 52.4 -70.8 -5.8 59.3 48.7 14.2 102 102 A Q T 3 S+ 0 0 85 -26,-0.4 -1,-0.3 -24,-0.4 2,-0.2 0.255 73.7 138.4-113.9 8.6 61.8 46.8 16.3 103 103 A L < + 0 0 0 -3,-1.5 -24,-0.2 1,-0.2 -23,-0.2 -0.373 17.9 166.8 -57.0 126.9 59.5 44.3 18.0 104 104 A H S S+ 0 0 59 -25,-2.7 24,-3.3 1,-0.3 25,-2.3 0.684 71.3 31.0-101.8 -41.6 60.9 40.7 18.2 105 105 A Y E +cd 80 129A 92 -26,-2.4 -24,-2.5 23,-0.2 2,-0.5 -0.966 66.9 178.2-128.4 117.6 58.4 39.1 20.6 106 106 A L E +cd 81 130A 0 23,-2.0 25,-2.4 -2,-0.5 2,-0.4 -0.986 2.3 174.4-126.7 119.8 54.8 40.2 20.8 107 107 A Y E +cd 82 131A 55 -26,-2.6 -24,-2.2 -2,-0.5 2,-0.4 -0.991 13.0 166.7-123.0 129.9 52.2 38.7 23.1 108 108 A I E +c 83 0A 0 23,-2.9 2,-0.3 -2,-0.4 -24,-0.2 -0.901 37.7 150.5-133.2 99.9 48.6 40.0 23.6 109 109 A T E +c 84 0A 4 -26,-2.4 -24,-1.7 -2,-0.4 -23,-0.4 -0.973 41.4 17.6-143.8 149.3 47.0 37.0 25.4 110 110 A H E S+ 0 0 102 23,-1.7 -24,-1.2 -2,-0.3 2,-0.2 0.938 95.8 111.6 55.0 45.7 44.4 36.0 27.9 111 111 A T E S-c 86 0A 7 23,-0.7 -1,-0.2 -26,-0.2 -24,-0.2 -0.772 81.7-107.1-130.0-172.7 42.5 39.3 27.4 112 112 A N + 0 0 64 -23,-1.8 -21,-0.5 -26,-0.7 23,-0.1 0.121 62.8 144.4-106.9 18.8 39.3 40.5 25.9 113 113 A V - 0 0 0 -23,-0.2 23,-2.7 1,-0.1 2,-0.2 -0.297 28.6-175.0 -57.7 144.7 40.9 42.1 22.9 114 114 A S E +l 136 0C 46 -23,-2.5 -21,-0.4 21,-0.1 23,-0.2 -0.536 31.3 61.1-133.9-169.9 38.6 41.7 19.8 115 115 A G E S-l 137 0C 24 21,-0.5 23,-2.4 -2,-0.2 2,-0.2 -0.233 89.2 -34.9 74.6-172.8 38.5 42.3 16.1 116 116 A A E -l 138 0C 52 21,-0.2 -23,-0.4 1,-0.1 23,-0.2 -0.517 59.4-102.3 -87.7 154.7 40.9 40.7 13.5 117 117 A I - 0 0 3 21,-0.5 23,-0.1 23,-0.3 -1,-0.1 -0.666 59.6-106.5 -69.5 127.4 44.5 39.9 13.8 118 118 A P > - 0 0 13 0, 0.0 3,-0.9 0, 0.0 4,-0.2 -0.264 16.8-148.5 -71.5 139.4 46.0 42.8 11.9 119 119 A D G > S+ 0 0 98 1,-0.2 3,-1.4 2,-0.1 4,-0.2 0.787 91.3 76.2 -70.1 -21.6 47.4 42.5 8.4 120 120 A F G > S+ 0 0 36 1,-0.3 3,-2.0 2,-0.1 4,-0.2 0.695 70.6 84.4 -65.3 -17.9 49.9 45.4 9.2 121 121 A L G X S+ 0 0 0 -3,-0.9 3,-2.4 1,-0.3 -1,-0.3 0.830 73.7 74.3 -58.8 -24.1 52.1 43.1 11.3 122 122 A S G < S+ 0 0 13 -3,-1.4 -1,-0.3 1,-0.3 -2,-0.1 0.736 87.0 62.6 -62.0 -20.4 53.9 41.9 8.1 123 123 A Q G < S+ 0 0 122 -3,-2.0 2,-1.4 -4,-0.2 -1,-0.3 0.574 80.4 86.8 -81.4 -8.4 55.7 45.2 7.9 124 124 A I X - 0 0 2 -3,-2.4 3,-1.9 -4,-0.2 -1,-0.2 -0.686 59.6-178.3 -93.5 83.9 57.5 44.6 11.2 125 125 A K T 3 S+ 0 0 106 -2,-1.4 25,-0.5 1,-0.3 -1,-0.2 0.662 71.0 64.0 -62.8 -18.4 60.4 42.7 9.8 126 126 A T T 3 S+ 0 0 28 -25,-0.4 -1,-0.3 -3,-0.1 -24,-0.1 0.567 71.4 130.4 -81.5 -8.1 62.1 42.0 13.2 127 127 A L < + 0 0 0 -3,-1.9 23,-0.3 -6,-0.2 -23,-0.2 -0.231 22.3 166.1 -52.8 125.3 59.2 39.8 14.4 128 128 A V + 0 0 26 -24,-3.3 24,-3.0 1,-0.4 25,-1.3 0.677 67.3 14.8-109.0 -40.5 60.4 36.4 15.8 129 129 A T E -de 105 153A 31 -25,-2.3 -23,-2.0 23,-0.2 2,-0.4 -0.998 56.4-164.5-140.2 146.6 57.2 35.3 17.7 130 130 A L E -de 106 154A 2 23,-1.6 25,-2.0 -2,-0.4 2,-0.4 -0.995 8.6-179.9-123.6 123.3 53.6 36.3 17.7 131 131 A D E +de 107 155A 28 -25,-2.4 -23,-2.9 -2,-0.4 25,-0.2 -0.936 19.2 151.1-127.2 109.4 51.2 35.1 20.5 132 132 A F + 0 0 0 23,-2.5 3,-0.4 -2,-0.4 5,-0.2 -0.166 32.2 146.7-119.1 36.9 47.6 36.3 20.3 133 133 A S + 0 0 7 22,-0.3 -23,-1.7 1,-0.2 25,-0.2 -0.386 52.0 16.1 -84.9 152.1 46.0 33.3 22.1 134 134 A Y S S+ 0 0 90 23,-2.4 -23,-0.7 -25,-0.2 -1,-0.2 0.852 92.7 109.4 63.3 54.4 43.0 33.2 24.4 135 135 A N S S- 0 0 17 -3,-0.4 -23,-0.2 23,-0.4 -21,-0.1 -0.212 82.9 -92.5-123.3-139.2 41.4 36.5 23.5 136 136 A A E +l 114 0C 7 -23,-2.7 -21,-0.5 -2,-0.1 23,-0.1 -0.177 63.0 155.8-130.4 33.3 38.2 37.4 21.6 137 137 A L E +l 115 0C 0 -23,-0.2 23,-2.7 -5,-0.2 -21,-0.2 -0.424 13.7 174.6 -66.8 144.0 39.7 37.8 18.2 138 138 A S E +l 116 0C 52 -23,-2.4 -21,-0.5 21,-0.1 23,-0.2 -0.509 33.0 67.9-128.3-163.1 37.5 37.2 15.1 139 139 A G S S- 0 0 29 21,-0.3 23,-2.4 -2,-0.2 2,-0.2 -0.353 86.7 -58.9 79.1-174.2 37.9 37.6 11.3 140 140 A T - 0 0 83 21,-0.2 -23,-0.3 -23,-0.1 23,-0.1 -0.635 62.8 -79.4-104.1 169.6 40.2 35.4 9.2 141 141 A L - 0 0 3 23,-0.4 -1,-0.1 21,-0.4 23,-0.1 -0.504 49.7-112.6 -68.9 131.6 43.9 34.8 9.4 142 142 A P > - 0 0 2 0, 0.0 3,-1.2 0, 0.0 4,-0.2 -0.538 24.4-157.4 -68.8 115.2 46.0 37.6 7.8 143 143 A P G > S+ 0 0 60 0, 0.0 3,-1.4 0, 0.0 4,-0.1 0.861 79.9 68.4 -65.1 -33.6 47.6 36.1 4.7 144 144 A S G > S+ 0 0 49 1,-0.2 3,-1.6 2,-0.1 4,-0.1 0.661 75.4 81.4 -69.5 -9.1 50.5 38.6 4.5 145 145 A I G X S+ 0 0 0 -3,-1.2 3,-2.0 1,-0.3 -1,-0.2 0.680 72.1 81.3 -72.3 -8.2 52.4 37.5 7.6 146 146 A S G < S+ 0 0 19 -3,-1.4 27,-0.3 1,-0.3 -1,-0.3 0.719 82.2 65.1 -64.6 -14.5 54.0 34.6 5.7 147 147 A S G < S+ 0 0 65 -3,-1.6 -1,-0.3 -4,-0.1 -2,-0.1 0.599 70.7 117.7 -82.5 -9.7 56.5 37.1 4.2 148 148 A L X - 0 0 2 -3,-2.0 3,-0.8 1,-0.2 25,-0.5 -0.413 52.4-158.8 -65.6 123.0 58.0 37.8 7.7 149 149 A P T 3 S+ 0 0 56 0, 0.0 26,-0.2 0, 0.0 -1,-0.2 0.712 82.5 38.5 -81.5 -21.0 61.6 36.6 7.4 150 150 A N T 3 S+ 0 0 75 -25,-0.5 2,-0.4 -23,-0.3 -2,-0.1 0.339 81.6 129.6-109.6 8.0 62.6 36.1 11.0 151 151 A L < + 0 0 0 -3,-0.8 -23,-0.2 1,-0.2 -22,-0.2 -0.516 25.7 173.4 -75.2 127.0 59.3 34.5 12.3 152 152 A V - 0 0 52 -24,-3.0 25,-2.7 -2,-0.4 26,-1.3 0.657 61.1 -4.4-100.3 -24.5 59.8 31.3 14.1 153 153 A G E -ef 129 178A 6 -25,-1.3 -23,-1.6 23,-0.2 2,-0.4 -0.991 46.1-146.3-169.6 154.1 56.2 30.7 15.4 154 154 A I E -ef 130 179A 0 24,-2.0 26,-2.1 -2,-0.3 2,-0.4 -0.986 7.8-169.1-124.3 139.2 52.6 31.8 15.7 155 155 A T E +ef 131 180A 45 -25,-2.0 -23,-2.5 -2,-0.4 -22,-0.3 -0.907 26.5 147.8-128.3 93.6 50.4 31.1 18.7 156 156 A F + 0 0 0 24,-3.2 3,-0.2 -2,-0.4 5,-0.2 0.143 25.4 142.8-115.9 17.2 46.8 32.0 17.8 157 157 A D + 0 0 13 23,-0.3 -23,-2.4 1,-0.2 -22,-0.2 -0.167 51.8 27.6 -62.7 149.3 44.9 29.4 19.8 158 158 A G S S+ 0 0 15 24,-2.3 -23,-0.4 -25,-0.2 26,-0.2 0.907 88.1 104.0 75.3 43.4 41.6 30.0 21.6 159 159 A N S S- 0 0 13 24,-1.3 -1,-0.2 23,-0.4 -21,-0.1 -0.508 80.5 -97.1-123.2-144.6 39.8 32.8 19.7 160 160 A R + 0 0 117 -23,-2.7 -21,-0.3 -2,-0.2 2,-0.2 -0.090 58.7 155.5-132.7 30.7 36.9 33.0 17.3 161 161 A I - 0 0 2 -23,-0.2 24,-2.6 -5,-0.2 2,-0.2 -0.515 18.8-175.9 -67.1 133.9 38.9 33.0 14.0 162 162 A S E +m 185 0D 49 -23,-2.4 -21,-0.4 -2,-0.2 24,-0.2 -0.639 31.3 56.5-128.7 174.1 37.0 31.8 11.0 163 163 A G E S-m 186 0D 22 22,-0.7 24,-1.9 -2,-0.2 2,-0.2 -0.290 87.2 -47.7 96.8 176.5 37.5 31.1 7.4 164 164 A A E -m 187 0D 43 22,-0.2 -23,-0.4 -2,-0.1 24,-0.2 -0.455 60.2 -98.6 -82.3 158.2 40.1 28.9 5.6 165 165 A I - 0 0 2 22,-0.5 24,-0.1 24,-0.4 -1,-0.1 -0.650 51.1-109.7 -75.0 124.3 43.8 28.8 6.4 166 166 A P > - 0 0 21 0, 0.0 3,-2.0 0, 0.0 4,-0.1 -0.245 12.7-129.7 -57.8 142.8 45.4 31.0 3.7 167 167 A D G > S+ 0 0 95 1,-0.3 3,-1.9 2,-0.2 4,-0.2 0.861 105.7 70.3 -61.7 -28.8 47.5 29.1 1.1 168 168 A S G > S+ 0 0 32 1,-0.3 3,-2.3 2,-0.2 -1,-0.3 0.766 77.1 79.1 -63.9 -13.7 50.2 31.7 1.8 169 169 A Y G < S+ 0 0 0 -3,-2.0 3,-0.3 1,-0.3 -1,-0.3 0.482 84.7 63.0 -75.2 2.2 50.8 30.0 5.3 170 170 A G G < S+ 0 0 0 -3,-1.9 -1,-0.3 1,-0.2 -2,-0.2 0.466 92.7 69.0 -93.6 -4.3 52.8 27.4 3.4 171 171 A S < + 0 0 78 -3,-2.3 -2,-0.2 -4,-0.2 -1,-0.2 0.304 64.0 126.4 -97.2 5.2 55.2 30.1 2.4 172 172 A F - 0 0 12 -3,-0.3 -25,-0.1 1,-0.1 -26,-0.1 -0.308 66.3 -98.4 -59.5 154.8 56.9 30.9 5.7 173 173 A S > - 0 0 41 -25,-0.5 3,-2.0 -27,-0.3 -1,-0.1 -0.098 36.9 -93.0 -63.8 174.6 60.7 30.7 5.6 174 174 A K T 3 S+ 0 0 190 1,-0.3 -1,-0.1 23,-0.1 -2,-0.1 0.669 122.6 65.6 -66.7 -16.9 62.9 27.8 6.9 175 175 A L T 3 S+ 0 0 68 -26,-0.2 2,-0.5 -24,-0.0 -1,-0.3 0.722 79.0 97.2 -80.9 -16.0 63.1 29.5 10.3 176 176 A F < + 0 0 3 -3,-2.0 22,-0.6 1,-0.2 -24,-0.2 -0.540 39.4 149.4 -76.2 116.4 59.4 29.0 10.8 177 177 A T + 0 0 56 -25,-2.7 23,-1.8 -2,-0.5 24,-1.7 0.433 47.5 57.9-131.8 4.2 58.8 25.9 12.9 178 178 A S E +fg 153 201A 27 -26,-1.3 -24,-2.0 22,-0.2 2,-0.4 -0.964 45.0 171.0-145.9 124.9 55.7 26.3 15.1 179 179 A M E +fg 154 202A 0 22,-2.3 24,-2.5 -2,-0.4 2,-0.5 -0.949 4.3 169.6-135.3 107.1 52.1 26.9 14.2 180 180 A T E +fg 155 203A 21 -26,-2.1 -24,-3.2 -2,-0.4 -23,-0.3 -0.992 15.5 148.0-123.7 123.8 49.3 26.6 16.8 181 181 A I + 0 0 0 22,-2.8 5,-0.2 -2,-0.5 23,-0.1 -0.114 29.2 149.5-142.1 35.3 45.8 27.9 15.9 182 182 A S + 0 0 4 21,-0.4 -24,-2.3 1,-0.2 -23,-0.4 -0.177 50.8 34.2 -68.1 162.2 43.7 25.4 17.9 183 183 A R S S+ 0 0 117 22,-2.1 -24,-1.3 -26,-0.2 2,-0.2 0.977 92.4 105.6 59.0 56.3 40.3 26.2 19.4 184 184 A N S S- 0 0 13 22,-1.7 -1,-0.2 21,-0.3 -22,-0.1 -0.616 80.6 -99.2-135.7-151.7 39.0 28.5 16.7 185 185 A R E +m 162 0D 132 -24,-2.6 -22,-0.7 -2,-0.2 22,-0.1 -0.184 55.3 156.2-133.2 33.8 36.4 28.1 13.9 186 186 A L E -m 163 0D 0 -24,-0.2 22,-2.5 -5,-0.2 2,-0.2 -0.431 18.2-172.2 -65.2 146.8 38.6 27.4 10.9 187 187 A T E +mn 164 208D 60 -24,-1.9 -22,-0.5 20,-0.1 22,-0.2 -0.724 38.6 39.9-132.5 170.9 36.9 25.6 8.0 188 188 A G E S- n 0 209D 13 20,-0.6 22,-3.2 -2,-0.2 2,-0.2 -0.421 89.6 -40.2 89.2-164.5 38.1 24.1 4.7 189 189 A K E - n 0 210D 88 20,-0.2 -24,-0.4 -2,-0.1 22,-0.1 -0.643 53.7 -98.8-102.5 161.1 41.2 22.1 4.1 190 190 A I - 0 0 7 20,-0.6 25,-0.1 22,-0.6 22,-0.1 -0.653 57.2-107.7 -74.6 126.6 44.9 22.3 5.1 191 191 A P > - 0 0 0 0, 0.0 3,-2.1 0, 0.0 4,-0.2 -0.221 13.7-132.2 -60.2 138.0 46.5 24.0 2.1 192 192 A P G > S+ 0 0 98 0, 0.0 3,-1.8 0, 0.0 4,-0.1 0.824 102.9 74.5 -57.1 -27.7 48.7 21.7 -0.1 193 193 A T G > S+ 0 0 44 1,-0.3 3,-1.9 2,-0.2 4,-0.1 0.680 72.8 84.5 -63.0 -12.9 51.4 24.4 0.1 194 194 A F G X + 0 0 2 -3,-2.1 3,-1.8 1,-0.3 -1,-0.3 0.670 67.8 81.0 -65.8 -10.3 52.0 23.2 3.7 195 195 A A G < S+ 0 0 57 -3,-1.8 -1,-0.3 1,-0.3 -2,-0.2 0.777 84.4 63.4 -63.6 -22.8 54.3 20.6 2.1 196 196 A N G < S+ 0 0 123 -3,-1.9 -1,-0.3 -4,-0.1 -2,-0.2 0.653 90.2 84.3 -73.5 -17.6 56.8 23.4 2.0 197 197 A L < - 0 0 9 -3,-1.8 2,-0.3 -4,-0.1 -20,-0.1 -0.478 59.3-158.9 -88.0 161.4 56.9 23.8 5.8 198 198 A N - 0 0 77 -22,-0.6 2,-0.5 -2,-0.2 3,-0.1 -0.759 26.1-170.2-133.7 77.3 59.0 21.8 8.3 199 199 A L - 0 0 7 -2,-0.3 -21,-0.2 1,-0.2 3,-0.2 -0.708 28.5-167.9 -85.2 130.4 57.1 22.2 11.5 200 200 A A S S+ 0 0 12 -23,-1.8 24,-2.8 -2,-0.5 25,-1.9 0.791 88.1 18.6 -68.4 -40.4 58.5 21.2 14.9 201 201 A F E +gh 178 225A 67 -24,-1.7 -22,-2.3 23,-0.2 2,-0.4 -0.981 63.3 174.4-136.4 134.7 54.9 21.7 16.3 202 202 A V E +gh 179 226A 5 23,-1.8 25,-2.6 -2,-0.4 2,-0.4 -0.998 2.2 174.8-140.3 126.4 51.5 22.0 14.6 203 203 A D E +gh 180 227A 28 -24,-2.5 -22,-2.8 -2,-0.4 -21,-0.4 -0.890 18.7 148.4-131.5 105.5 48.3 22.3 16.5 204 204 A L + 0 0 0 23,-2.4 5,-0.2 -2,-0.4 24,-0.2 0.002 32.6 143.8-119.2 28.3 45.1 22.8 14.5 205 205 A S + 0 0 9 22,-0.5 -22,-2.1 1,-0.2 -21,-0.3 -0.130 53.0 28.9 -69.2 155.9 42.9 20.9 17.0 206 206 A R S S+ 0 0 92 23,-2.3 -22,-1.7 -24,-0.2 2,-0.2 0.940 92.0 105.8 57.1 57.8 39.3 21.9 17.8 207 207 A N S S- 0 0 13 23,-1.2 -1,-0.2 22,-0.3 -20,-0.1 -0.612 81.6-103.8-134.4-160.4 38.3 23.6 14.5 208 208 A M E +n 187 0D 98 -22,-2.5 -20,-0.6 -2,-0.2 23,-0.1 -0.215 59.2 155.0-124.6 42.5 36.1 22.4 11.7 209 209 A L E -n 188 0D 0 -5,-0.2 23,-2.8 -22,-0.2 2,-0.3 -0.412 22.2-163.4 -73.9 148.9 38.9 21.4 9.2 210 210 A E E +no 189 232D 110 -22,-3.2 -20,-0.6 21,-0.1 23,-0.3 -0.776 36.9 14.6-127.8 166.9 38.1 18.8 6.6 211 211 A G E S+ o 0 233D 27 21,-1.0 23,-1.9 -2,-0.3 2,-0.2 -0.259 94.3 5.5 84.2-155.3 40.0 16.6 4.2 212 212 A D + 0 0 86 21,-0.2 -22,-0.6 1,-0.1 23,-0.1 -0.522 36.3 174.0 -85.6 129.9 43.6 15.4 3.9 213 213 A A > + 0 0 0 -2,-0.2 3,-2.0 -24,-0.1 4,-0.3 0.134 50.0 113.0-111.1 14.2 46.2 16.3 6.5 214 214 A S G > + 0 0 38 1,-0.3 3,-2.4 2,-0.2 27,-0.2 0.831 63.5 72.4 -56.2 -28.8 48.9 14.1 4.9 215 215 A V G 3 S+ 0 0 30 1,-0.3 -1,-0.3 -25,-0.1 -2,-0.1 0.786 90.3 58.4 -59.6 -23.1 50.9 17.2 4.0 216 216 A L G < S+ 0 0 11 -3,-2.0 -1,-0.3 -18,-0.1 -2,-0.2 0.560 99.7 73.6 -86.4 -2.6 51.8 17.7 7.6 217 217 A F < + 0 0 14 -3,-2.4 25,-0.2 -4,-0.3 2,-0.1 -0.464 51.7 131.4-107.2 166.5 53.5 14.3 7.8 218 218 A G > - 0 0 10 23,-1.4 3,-1.0 -2,-0.2 5,-0.1 -0.416 54.4-126.1 156.5 137.5 56.8 13.0 6.3 219 219 A S T 3 S+ 0 0 92 1,-0.2 25,-0.5 -2,-0.1 -1,-0.1 0.628 111.7 59.9 -76.4 -8.4 59.8 11.0 7.3 220 220 A D T 3 S+ 0 0 127 23,-0.1 -1,-0.2 -3,-0.1 2,-0.1 0.510 90.2 94.6 -89.3 -5.9 61.9 14.0 6.0 221 221 A K S < S- 0 0 25 -3,-1.0 2,-0.7 1,-0.0 24,-0.4 -0.441 71.0-137.9 -87.4 159.4 60.4 16.4 8.5 222 222 A N + 0 0 80 -2,-0.1 2,-0.4 21,-0.1 -3,-0.1 -0.865 44.7 155.7-113.4 86.5 61.6 17.3 11.9 223 223 A T + 0 0 5 -2,-0.7 -23,-0.2 -5,-0.1 -22,-0.2 -0.981 28.1 177.6-123.9 128.5 58.4 17.3 13.9 224 224 A Q S S+ 0 0 71 -24,-2.8 23,-3.1 -2,-0.4 24,-1.6 0.781 74.3 22.7 -93.9 -42.3 57.9 16.8 17.6 225 225 A K E -hi 201 248A 67 -25,-1.9 -23,-1.8 22,-0.2 2,-0.5 -0.997 50.9-175.6-134.1 136.6 54.1 17.2 17.9 226 226 A I E +hi 202 249A 4 22,-2.3 24,-2.8 -2,-0.4 2,-0.5 -0.992 13.4 177.3-125.8 110.7 51.2 16.8 15.6 227 227 A H E +hi 203 250A 45 -25,-2.6 -23,-2.4 -2,-0.5 -22,-0.5 -0.974 20.5 143.3-120.0 110.7 47.9 17.8 17.2 228 228 A L + 0 0 0 22,-3.1 5,-0.2 -2,-0.5 3,-0.2 0.115 25.2 149.0-132.5 21.5 44.8 17.6 14.9 229 229 A A + 0 0 1 21,-0.6 -23,-2.3 1,-0.2 -22,-0.3 -0.119 55.9 23.4 -59.7 154.5 42.1 16.4 17.3 230 230 A K S S+ 0 0 74 22,-2.2 -23,-1.2 -25,-0.2 2,-0.2 0.946 90.8 106.9 54.8 61.4 38.4 17.3 16.9 231 231 A N S S- 0 0 19 22,-1.4 -1,-0.2 21,-0.3 -21,-0.1 -0.625 79.1-104.2-132.7-154.0 38.1 18.3 13.3 232 232 A S E +o 210 0D 42 -23,-2.8 -21,-1.0 -2,-0.2 2,-0.1 -0.269 59.9 154.9-132.5 44.9 36.4 16.5 10.3 233 233 A L E -o 211 0D 0 -23,-0.3 22,-2.8 -5,-0.2 2,-0.3 -0.471 18.0-178.3 -74.3 149.4 39.7 15.2 8.7 234 234 A A + 0 0 23 -23,-1.9 2,-0.3 -2,-0.1 22,-0.2 -0.946 21.2 121.4-153.6 120.6 39.6 12.2 6.4 235 235 A F - 0 0 5 -2,-0.3 22,-2.4 20,-0.2 2,-1.1 -0.945 67.3 -81.2-166.2 164.3 42.6 10.5 4.6 236 236 A D B > -p 257 0E 38 -2,-0.3 3,-1.4 1,-0.2 22,-0.2 -0.712 38.7-171.8 -82.2 99.9 44.4 7.2 4.5 237 237 A L G > S+ 0 0 3 20,-2.7 3,-1.9 -2,-1.1 -1,-0.2 0.817 76.6 71.4 -64.2 -24.8 46.7 7.3 7.5 238 238 A G G 3 S+ 0 0 26 19,-0.5 -1,-0.3 1,-0.3 24,-0.2 0.692 92.6 59.1 -66.2 -16.5 48.5 4.1 6.5 239 239 A K G < S+ 0 0 160 -3,-1.4 -1,-0.3 22,-0.1 2,-0.2 0.494 82.3 107.7 -89.9 -5.6 50.2 6.0 3.7 240 240 A V < - 0 0 16 -3,-1.9 23,-0.2 -4,-0.2 2,-0.2 -0.503 61.1-137.0 -86.2 145.6 52.0 8.6 5.8 241 241 A G - 0 0 31 -2,-0.2 -23,-1.4 -27,-0.2 2,-0.4 -0.479 24.8-138.3 -81.4 155.6 55.7 8.9 6.5 242 242 A L - 0 0 18 -25,-0.2 2,-0.2 -2,-0.2 -23,-0.1 -0.973 10.3-118.5-126.5 135.0 56.7 9.8 10.1 243 243 A S > - 0 0 5 -2,-0.4 3,-2.1 1,-0.2 -24,-0.1 -0.392 18.4-136.5 -66.4 137.1 59.3 12.1 11.6 244 244 A K T 3 S+ 0 0 133 -25,-0.5 25,-0.4 -23,-0.3 24,-0.3 0.750 103.6 61.5 -63.8 -18.7 61.8 10.3 13.7 245 245 A N T 3 S+ 0 0 46 -24,-0.4 -1,-0.3 -22,-0.1 2,-0.2 0.461 73.3 129.5 -83.7 -4.1 61.5 13.2 16.2 246 246 A L < + 0 0 1 -3,-2.1 23,-0.3 1,-0.2 -22,-0.2 -0.358 18.3 159.7 -61.8 125.3 57.8 12.7 16.9 247 247 A N + 0 0 35 -23,-3.1 24,-2.8 1,-0.3 25,-1.5 0.529 67.3 36.7-115.2 -16.2 56.9 12.5 20.6 248 248 A G E +ij 225 272A 0 -24,-1.6 -22,-2.3 23,-0.2 2,-0.4 -0.980 53.3 173.6-145.0 126.4 53.2 13.3 20.4 249 249 A L E +ij 226 273A 4 23,-2.0 25,-2.4 -2,-0.3 2,-0.5 -0.944 7.0 174.5-134.2 108.9 50.5 12.4 17.8 250 250 A D E +ij 227 274A 26 -24,-2.8 -22,-3.1 -2,-0.4 -21,-0.6 -0.919 18.8 144.9-123.4 105.7 46.9 13.3 18.6 251 251 A L + 0 0 1 23,-3.0 5,-0.2 -2,-0.5 24,-0.2 0.221 26.6 146.6-121.1 15.2 44.4 12.6 15.8 252 252 A R + 0 0 87 22,-0.6 -22,-2.2 1,-0.2 -21,-0.3 0.005 56.8 25.2 -58.4 152.8 41.3 11.7 18.0 253 253 A N S S+ 0 0 54 23,-2.1 -22,-1.4 -24,-0.2 2,-0.2 0.983 92.3 105.7 58.8 64.8 37.8 12.5 16.9 254 254 A N S S- 0 0 12 23,-2.1 -1,-0.2 22,-0.3 -20,-0.1 -0.702 79.2-105.0-143.8-161.9 38.1 12.8 13.1 255 255 A R + 0 0 113 -22,-2.8 -20,-0.2 -2,-0.2 23,-0.1 -0.213 59.9 152.9-125.9 39.2 37.1 10.5 10.2 256 256 A I - 0 0 0 -5,-0.2 23,-2.4 -22,-0.2 2,-0.2 -0.480 20.5-174.5 -74.7 140.7 40.6 9.2 9.4 257 257 A Y E +pq 236 279E 110 -22,-2.4 -20,-2.7 21,-0.1 -19,-0.5 -0.662 32.6 58.9-129.3-173.7 40.8 5.8 7.8 258 258 A G E S- q 0 280E 20 21,-0.6 23,-2.3 -22,-0.2 2,-0.2 -0.471 88.4 -47.0 89.9-167.2 43.1 3.0 6.6 259 259 A T - 0 0 67 21,-0.2 23,-0.1 -2,-0.1 -20,-0.1 -0.485 58.8 -96.3 -95.9 169.1 45.6 1.3 8.9 260 260 A L - 0 0 4 23,-0.3 -22,-0.1 21,-0.3 2,-0.1 -0.761 55.5-104.3 -75.5 139.1 48.0 2.7 11.4 261 261 A P > - 0 0 9 0, 0.0 3,-2.0 0, 0.0 4,-0.2 -0.326 14.9-133.0 -71.4 138.1 51.4 3.0 9.6 262 262 A Q G > S+ 0 0 122 1,-0.3 3,-2.4 -24,-0.2 4,-0.3 0.839 99.3 77.8 -59.4 -32.4 54.0 0.4 10.4 263 263 A G G > S+ 0 0 37 1,-0.3 3,-1.4 -23,-0.2 4,-0.4 0.673 73.9 79.5 -49.8 -23.6 56.5 3.2 10.8 264 264 A L G X S+ 0 0 2 -3,-2.0 3,-1.0 1,-0.2 25,-0.4 0.786 82.5 63.8 -59.9 -29.2 55.1 4.0 14.2 265 265 A T G < S+ 0 0 20 -3,-2.4 -1,-0.2 1,-0.2 23,-0.2 0.706 97.7 56.8 -70.8 -17.0 57.0 1.1 15.7 266 266 A Q G < S+ 0 0 142 -3,-1.4 2,-0.8 -4,-0.3 -1,-0.2 0.536 76.4 108.4 -87.2 -6.3 60.3 2.9 14.8 267 267 A L X - 0 0 5 -3,-1.0 3,-0.8 -4,-0.4 22,-0.4 -0.602 47.0-172.4 -76.8 108.3 59.6 6.1 16.7 268 268 A K T 3 S+ 0 0 126 -2,-0.8 -1,-0.2 -24,-0.3 -23,-0.1 0.703 80.8 42.7 -72.6 -24.5 61.9 6.1 19.7 269 269 A F T 3 S+ 0 0 87 -25,-0.4 2,-0.5 -23,-0.3 -1,-0.2 0.321 72.7 133.1-108.8 14.6 60.4 9.1 21.4 270 270 A L < + 0 0 1 -3,-0.8 -23,-0.2 1,-0.2 -22,-0.2 -0.544 15.6 153.6 -71.7 114.0 56.7 8.6 21.0 271 271 A H + 0 0 134 -24,-2.8 2,-0.4 -2,-0.5 -23,-0.2 0.471 59.9 40.9-119.9 -13.6 55.2 9.3 24.4 272 272 A S E +j 248 0A 50 -25,-1.5 -23,-2.0 21,-0.0 2,-0.3 -0.984 61.6 165.0-139.7 129.9 51.7 10.4 23.7 273 273 A L E +j 249 0A 10 -2,-0.4 2,-0.3 -25,-0.2 -23,-0.2 -0.981 5.5 168.8-144.5 131.0 49.4 8.8 21.1 274 274 A N E +j 250 0A 20 -25,-2.4 -23,-3.0 -2,-0.3 -22,-0.6 -0.911 15.0 151.1-146.4 116.9 45.6 9.1 20.5 275 275 A V + 0 0 1 22,-2.9 5,-0.3 -2,-0.3 23,-0.2 0.122 35.1 136.2-125.6 13.6 43.8 7.9 17.4 276 276 A S + 0 0 6 21,-0.5 -23,-2.1 1,-0.2 -22,-0.3 -0.051 56.0 33.7 -62.5 156.9 40.4 7.1 19.1 277 277 A F S S+ 0 0 102 22,-1.5 -23,-2.1 -25,-0.2 2,-0.2 0.968 94.1 105.5 59.2 56.7 37.1 8.1 17.5 278 278 A N S S- 0 0 6 22,-0.9 -1,-0.2 21,-0.2 -23,-0.1 -0.766 81.3-102.3-139.3-167.3 38.2 7.6 13.8 279 279 A N E +q 257 0E 77 -23,-2.4 -21,-0.6 -2,-0.2 22,-0.1 -0.164 61.9 149.0-113.4 32.6 37.5 4.9 11.1 280 280 A L E -q 258 0E 1 -5,-0.3 23,-2.5 -23,-0.2 22,-1.0 -0.388 21.1-176.7 -70.8 155.5 40.9 3.1 11.3 281 281 A c E +r 303 0F 45 -23,-2.3 23,-0.3 21,-0.2 -21,-0.3 -0.926 31.6 46.8-146.0 158.0 41.0 -0.7 10.6 282 282 A G E S-r 304 0F 21 21,-1.9 23,-1.8 -2,-0.3 2,-0.3 -0.309 89.9 -28.5 101.5 173.3 43.6 -3.5 10.6 283 283 A E E -r 305 0F 114 21,-0.2 -23,-0.3 -2,-0.1 23,-0.2 -0.544 59.1-120.8 -71.9 138.7 46.3 -4.7 13.0 284 284 A I - 0 0 0 21,-3.1 23,-0.1 -2,-0.3 -1,-0.1 -0.547 42.8-100.7 -69.6 129.2 47.9 -2.2 15.4 285 285 A P - 0 0 0 0, 0.0 2,-0.7 0, 0.0 -1,-0.1 -0.202 35.2-137.5 -53.0 129.2 51.6 -2.3 14.6 286 286 A Q + 0 0 77 4,-0.1 2,-0.3 -3,-0.1 -21,-0.1 -0.865 63.2 44.7 -97.9 109.6 53.4 -4.4 17.3 287 287 A G S > S+ 0 0 27 -2,-0.7 3,-1.5 1,-0.1 4,-0.3 -0.874 76.5 50.8 148.3-179.8 56.6 -2.8 18.5 288 288 A G T 3 S- 0 0 44 -2,-0.3 3,-0.3 1,-0.2 -23,-0.2 -0.197 119.8 -38.0 55.9-137.3 58.2 0.5 19.6 289 289 A N T >> S+ 0 0 36 -25,-0.4 3,-1.7 -22,-0.4 4,-0.6 0.418 108.4 108.3 -97.0 2.0 56.1 2.2 22.3 290 290 A L G X4 S+ 0 0 0 -3,-1.5 3,-0.6 1,-0.3 -1,-0.2 0.814 77.1 48.4 -52.5 -38.3 52.7 1.2 20.8 291 291 A Q G 34 S+ 0 0 57 -4,-0.3 -1,-0.3 -3,-0.3 -2,-0.1 0.551 98.1 71.4 -86.6 0.9 51.7 -1.4 23.3 292 292 A R G <4 S+ 0 0 209 -3,-1.7 -1,-0.2 2,-0.1 -2,-0.2 0.758 81.5 90.9 -81.0 -20.0 52.6 1.0 26.2 293 293 A F S << S- 0 0 29 -4,-0.6 -19,-0.0 -3,-0.6 -21,-0.0 -0.459 86.4-106.4 -80.6 141.5 49.5 3.1 25.4 294 294 A D > - 0 0 105 -2,-0.1 3,-1.8 1,-0.1 4,-0.3 -0.275 29.0-109.7 -57.3 159.6 46.2 2.4 27.1 295 295 A V G >> S+ 0 0 63 1,-0.3 3,-2.4 2,-0.2 4,-1.6 0.843 115.5 70.4 -57.7 -35.2 43.4 0.8 25.1 296 296 A S G 34 S+ 0 0 70 1,-0.3 -1,-0.3 2,-0.2 -20,-0.2 0.740 87.0 65.9 -60.0 -19.7 41.5 4.1 25.2 297 297 A A G <4 S+ 0 0 5 -3,-1.8 -22,-2.9 1,-0.2 -21,-0.5 0.670 116.0 25.9 -74.1 -15.1 44.1 5.6 22.8 298 298 A Y T <4 S+ 0 0 1 -3,-2.4 3,-0.2 -4,-0.3 -2,-0.2 0.452 97.7 112.0-123.3 -14.4 42.9 3.2 20.0 299 299 A A < + 0 0 25 -4,-1.6 -22,-1.5 1,-0.2 -21,-0.2 0.051 60.7 39.6 -65.6 165.5 39.3 2.4 20.9 300 300 A N S S+ 0 0 100 -24,-0.2 -22,-0.9 1,-0.2 -1,-0.2 0.912 83.3 128.4 64.3 38.6 36.2 3.5 19.1 301 301 A N S S- 0 0 29 -3,-0.2 -22,-0.2 -24,-0.2 -1,-0.2 -0.515 70.7-101.2-105.1-173.4 37.7 2.9 15.6 302 302 A K S S- 0 0 162 -22,-1.0 -21,-0.2 -2,-0.2 -23,-0.1 0.959 95.8 -21.7 -76.6 -59.0 36.2 0.9 12.8 303 303 A c E S+r 281 0F 57 -23,-2.5 -21,-1.9 2,-0.0 -22,-0.2 -0.066 79.4 151.9-150.7 43.8 38.1 -2.4 12.9 304 304 A L E +r 282 0F 20 -24,-0.5 2,-0.3 -23,-0.3 -21,-0.2 -0.510 17.7 168.9 -70.7 154.4 41.4 -2.1 14.7 305 305 A d E +r 283 0F 24 -23,-1.8 -21,-3.1 -2,-0.2 6,-0.2 -0.957 23.6 71.7-158.0 166.6 42.7 -5.2 16.4 306 306 A G S > S+ 0 0 4 4,-3.0 3,-2.5 -2,-0.3 5,-0.1 -0.049 80.8 4.8 101.0 150.2 45.9 -6.5 18.0 307 307 A S T 3 S+ 0 0 59 1,-0.4 -2,-0.1 -23,-0.1 -23,-0.0 -0.236 129.4 22.9 -50.3 114.0 47.5 -5.6 21.3 308 308 A P T 3 S+ 0 0 42 0, 0.0 -1,-0.4 0, 0.0 -13,-0.1 -0.987 128.8 55.7-102.8 -1.6 46.3 -3.6 23.4 309 309 A L S < S- 0 0 28 -3,-2.5 3,-0.1 1,-0.2 -4,-0.1 -0.508 107.8 -69.8 -88.8 171.1 42.9 -4.5 21.7 310 310 A P S S- 0 0 105 0, 0.0 -4,-3.0 0, 0.0 -1,-0.2 -0.159 70.3 -80.6 -55.7 155.2 41.5 -8.0 21.2 311 311 A A - 0 0 88 -6,-0.2 2,-0.1 1,-0.1 -28,-0.0 -0.080 42.8-111.7 -60.6 148.5 43.4 -10.2 18.7 312 312 A d 0 0 46 -3,-0.1 -1,-0.1 -7,-0.1 -5,-0.0 -0.491 360.0 360.0 -72.5 151.9 42.9 -9.9 15.0 313 313 A T 0 0 193 -2,-0.1 -1,-0.1 0, 0.0 -8,-0.0 -0.450 360.0 360.0 -90.7 360.0 41.1 -12.9 13.4