==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=3-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 31-JAN-07 2OQ5 . COMPND 2 MOLECULE: TRANSMEMBRANE PROTEASE, SERINE 11E; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR O.J.P.KYRIELEIS,R.HUBER,E.L.MADISON,JACOB U. . 232 1 3 3 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 10467.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 143 61.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 2 0.9 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 77 33.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 4 1.7 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 16 6.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 28 12.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 9 3.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 2 2 4 3 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 16 A I 0 0 0 0, 0.0 2,-0.4 0, 0.0 3,-0.4 0.000 360.0 360.0 360.0 127.7 -2.6 17.5 28.5 2 17 A V B +A 176 0A 22 174,-3.4 174,-1.7 1,-0.2 127,-0.1 -0.889 360.0 7.6-104.4 133.1 -5.4 17.3 30.9 3 18 A G S S+ 0 0 56 -2,-0.4 139,-0.3 125,-0.3 -1,-0.2 0.738 102.4 123.2 72.8 25.2 -6.3 14.0 32.6 4 19 A G - 0 0 12 -3,-0.4 2,-0.3 137,-0.1 137,-0.2 -0.341 52.9-124.6-107.3-171.6 -3.3 12.2 31.3 5 20 A T E -B 140 0B 82 135,-2.1 135,-2.4 -2,-0.1 2,-0.1 -0.943 29.8 -95.7-134.9 156.0 -0.3 10.3 32.6 6 21 A E E -B 139 0B 119 -2,-0.3 2,-0.2 133,-0.2 133,-0.2 -0.393 42.7-137.8 -70.0 146.3 3.5 10.5 32.2 7 22 A V - 0 0 1 131,-2.0 2,-0.2 51,-0.2 131,-0.1 -0.682 5.7-120.7-107.9 162.5 5.1 8.3 29.6 8 23 A E > - 0 0 141 -2,-0.2 3,-1.5 1,-0.1 4,-0.4 -0.589 45.1 -86.4 -93.5 158.6 8.2 6.2 29.4 9 24 A E T 3 S+ 0 0 108 1,-0.2 -1,-0.1 -2,-0.2 92,-0.0 -0.429 113.3 26.3 -67.0 135.3 10.9 6.8 26.8 10 25 A G T 3 S+ 0 0 35 91,-0.4 -1,-0.2 -2,-0.1 92,-0.0 0.267 89.7 101.5 97.5 -11.4 10.2 5.0 23.5 11 26 A E S < S+ 0 0 88 -3,-1.5 -2,-0.1 1,-0.3 90,-0.0 0.890 98.8 17.7 -72.2 -40.2 6.4 4.9 23.8 12 27 A W S > S+ 0 0 20 -4,-0.4 3,-1.7 89,-0.1 -1,-0.3 -0.612 73.9 171.5-133.3 72.2 5.8 7.8 21.4 13 28 A P T 3 S+ 0 0 6 0, 0.0 90,-0.5 0, 0.0 44,-0.2 0.626 70.7 62.0 -57.7 -21.2 9.1 8.2 19.5 14 29 A W T 3 S+ 0 0 9 88,-0.2 16,-2.3 90,-0.1 91,-0.1 0.501 74.8 117.2 -87.2 -6.3 7.7 10.8 17.0 15 30 A Q E < -J 29 0C 2 -3,-1.7 42,-0.7 14,-0.2 2,-0.3 -0.406 41.3-177.6 -67.1 136.0 6.9 13.5 19.6 16 31 A A E -JK 28 56C 0 12,-2.1 12,-1.4 40,-0.2 2,-0.5 -0.937 20.8-141.8-133.3 153.5 8.8 16.7 19.2 17 32 A S E -JK 27 55C 0 38,-2.3 38,-2.1 -2,-0.3 2,-0.5 -0.977 13.5-150.1-115.2 128.6 8.9 19.9 21.2 18 33 A L E -JK 26 54C 0 8,-3.5 7,-2.9 -2,-0.5 8,-1.6 -0.904 17.6-169.0-101.3 123.8 9.2 23.2 19.3 19 34 A Q E -JK 24 53C 2 34,-3.0 34,-2.2 -2,-0.5 2,-0.6 -0.942 16.1-155.8-120.2 135.6 11.0 25.9 21.3 20 36 A W E > S-JK 23 52C 20 3,-2.4 3,-1.7 -2,-0.4 32,-0.2 -0.955 88.4 -13.6-107.5 120.2 11.4 29.6 20.6 21 37 A D T 3 S- 0 0 85 30,-2.4 -1,-0.2 -2,-0.6 31,-0.1 0.874 133.5 -51.8 54.4 38.0 14.5 31.1 22.2 22 38 A G T 3 S+ 0 0 51 29,-0.4 2,-0.5 -3,-0.2 -1,-0.3 0.504 114.8 113.4 80.4 4.8 14.7 27.9 24.3 23 39 A S E < S-J 20 0C 75 -3,-1.7 -3,-2.4 0, 0.0 -1,-0.2 -0.945 70.7-114.5-115.9 129.8 11.1 27.9 25.6 24 40 A H E +J 19 0C 23 -2,-0.5 -5,-0.3 -5,-0.2 110,-0.2 -0.339 46.1 153.0 -59.4 128.6 8.6 25.3 24.7 25 41 A R E + 0 0 116 -7,-2.9 2,-0.3 1,-0.4 155,-0.3 0.615 59.4 9.0-127.4 -29.0 5.7 26.7 22.7 26 42 A a E -J 18 0C 7 -8,-1.6 -8,-3.5 155,-0.1 -1,-0.4 -0.980 59.6-122.7-154.0 160.2 4.3 23.9 20.6 27 43 A G E -J 17 0C 0 155,-3.0 12,-0.4 -2,-0.3 2,-0.3 -0.526 28.5-179.1 -96.1 169.4 4.4 20.2 19.8 28 44 A A E -J 16 0C 0 -12,-1.4 -12,-2.1 -2,-0.2 2,-0.4 -0.948 20.3-124.9-159.4 168.5 5.2 18.7 16.5 29 45 A T E -JL 15 37C 0 8,-2.4 8,-2.4 -2,-0.3 2,-0.5 -0.989 17.3-127.2-130.7 132.6 5.4 15.2 14.9 30 46 A L E + L 0 36C 3 -16,-2.3 75,-1.9 -2,-0.4 6,-0.2 -0.651 34.0 163.6 -77.6 120.6 8.3 13.6 13.1 31 47 A I E + 0 0 2 4,-2.4 2,-0.3 -2,-0.5 5,-0.2 0.532 68.5 7.7-112.6 -12.4 7.1 12.3 9.7 32 48 A N E > S- L 0 35C 47 3,-1.4 3,-0.7 71,-0.0 -1,-0.3 -0.936 89.2 -89.5-157.8 168.1 10.5 11.9 8.0 33 49 A A T 3 S+ 0 0 41 -2,-0.3 63,-2.2 1,-0.2 61,-0.1 0.778 128.9 22.5 -58.3 -25.2 14.2 12.1 9.0 34 50 A T T 3 S+ 0 0 34 61,-0.2 58,-2.6 59,-0.1 2,-0.4 0.262 112.1 81.7-126.4 11.8 14.2 15.8 8.2 35 51 A W E < -LM 32 91C 21 -3,-0.7 -4,-2.4 56,-0.2 -3,-1.4 -0.965 45.3-175.5-129.8 138.6 10.5 16.8 8.4 36 52 A L E -LM 30 90C 1 54,-2.4 54,-2.4 -2,-0.4 2,-0.4 -0.929 13.6-150.2-121.5 146.7 8.1 17.7 11.1 37 53 A V E +LM 29 89C 0 -8,-2.4 -8,-2.4 -2,-0.3 52,-0.2 -0.942 32.1 145.6-115.8 139.1 4.4 18.4 10.8 38 54 A S E - M 0 88C 2 50,-2.6 50,-2.2 -2,-0.4 2,-0.3 -0.722 48.6 -63.0-149.1-161.9 2.8 20.9 13.2 39 55 A A > - 0 0 0 -12,-0.4 3,-1.0 48,-0.3 4,-0.3 -0.780 31.5-133.8-100.2 145.9 0.0 23.5 13.4 40 56 A A G > S+ 0 0 1 -2,-0.3 3,-1.9 1,-0.2 4,-0.1 0.870 102.9 64.3 -63.1 -37.7 0.1 26.7 11.4 41 57 A H G > S+ 0 0 52 1,-0.3 3,-0.9 2,-0.2 4,-0.4 0.694 87.3 71.3 -63.3 -16.4 -0.9 28.8 14.4 42 58 A a G < S+ 0 0 9 -3,-1.0 4,-0.3 1,-0.2 -1,-0.3 0.751 105.7 39.1 -68.9 -23.1 2.4 27.9 16.1 43 60 A F G < S+ 0 0 8 -3,-1.9 -1,-0.2 -4,-0.3 -2,-0.2 0.203 84.8 102.4-113.6 16.5 4.2 30.1 13.6 44 61 A T S < S+ 0 0 44 -3,-0.9 3,-0.2 -4,-0.1 -2,-0.1 0.913 99.2 14.5 -65.9 -47.3 1.7 33.1 13.3 45 62 A T S S+ 0 0 102 -4,-0.4 2,-0.9 1,-0.2 -1,-0.1 0.854 128.4 48.6 -96.8 -46.3 3.7 35.5 15.5 46 63 A Y + 0 0 77 -4,-0.3 -1,-0.2 1,-0.1 -2,-0.0 -0.829 62.9 150.7-101.2 97.6 7.2 34.0 15.8 47 64 A K + 0 0 155 -2,-0.9 -1,-0.1 -3,-0.2 25,-0.1 0.357 27.2 113.0-111.9 5.7 8.2 33.1 12.2 48 64AA N > - 0 0 83 1,-0.2 3,-1.6 23,-0.0 4,-0.3 -0.714 51.9-156.2 -83.1 111.9 12.0 33.3 12.1 49 64BA P G > S+ 0 0 35 0, 0.0 3,-1.5 0, 0.0 20,-0.7 0.814 86.8 67.5 -54.7 -35.4 13.4 29.8 11.6 50 64CA A G 3 S+ 0 0 85 1,-0.3 -2,-0.0 18,-0.1 20,-0.0 0.702 100.7 47.4 -61.8 -22.8 16.7 30.7 13.2 51 64DA R G < S+ 0 0 125 -3,-1.6 -30,-2.4 -30,-0.0 2,-0.4 0.412 97.0 86.7-101.1 2.5 15.2 31.2 16.6 52 64EA W E < +K 20 0C 2 -3,-1.5 17,-0.9 -4,-0.3 2,-0.3 -0.813 52.9 179.2-102.1 140.0 13.2 27.9 16.6 53 65 A T E -KN 19 68C 41 -34,-2.2 -34,-3.0 -2,-0.4 2,-0.4 -0.956 15.8-144.7-136.2 154.2 14.7 24.6 17.7 54 66 A A E -KN 18 67C 0 13,-3.0 13,-2.6 -2,-0.3 2,-0.3 -0.957 14.4-170.9-122.0 139.7 13.1 21.1 18.0 55 67 A S E -KN 17 66C 1 -38,-2.1 -38,-2.3 -2,-0.4 2,-0.3 -0.936 5.5-153.5-129.3 154.8 13.9 18.5 20.6 56 68 A F E +KN 16 65C 1 9,-1.8 8,-1.2 -2,-0.3 9,-0.6 -0.788 46.1 56.3-124.3 166.8 13.0 14.9 21.0 57 69 A G S S- 0 0 9 -42,-0.7 6,-0.1 -2,-0.3 -2,-0.1 -0.568 93.9 -63.4 107.5-172.6 12.5 12.4 23.8 58 69AA V S S+ 0 0 17 -2,-0.2 80,-3.1 79,-0.1 2,-0.3 0.477 112.0 52.8 -94.5 -3.5 10.2 12.4 26.8 59 74 A T B -P 137 0D 26 -3,-0.2 5,-0.3 78,-0.2 78,-0.2 -0.953 55.6-156.5-133.1 151.1 11.7 15.5 28.5 60 75 A I S > S+ 0 0 29 76,-1.8 3,-0.8 -2,-0.3 -1,-0.1 0.792 93.4 63.9 -87.8 -33.5 12.5 19.0 27.5 61 76 A K T 3 S+ 0 0 154 75,-0.4 2,-2.3 1,-0.3 76,-0.0 0.970 113.5 20.9 -57.3 -90.9 15.2 19.2 30.3 62 77 A P T 3 S- 0 0 96 0, 0.0 -1,-0.3 0, 0.0 -3,-0.2 -0.451 91.4-160.5 -84.1 75.3 17.9 16.6 29.4 63 78 A S < - 0 0 38 -2,-2.3 3,-0.2 -3,-0.8 -6,-0.1 -0.282 16.3-142.8 -54.4 128.8 16.9 16.6 25.7 64 79 A K S S- 0 0 95 -8,-1.2 2,-0.3 -5,-0.3 -1,-0.1 0.881 80.3 -13.1 -60.5 -40.9 18.1 13.5 23.9 65 80 A M E -N 56 0C 40 -9,-0.6 -9,-1.8 2,-0.0 2,-0.3 -0.967 62.5-154.0-162.9 146.6 18.8 15.5 20.8 66 81 A K E -N 55 0C 101 -2,-0.3 2,-0.3 -11,-0.2 -11,-0.2 -0.900 8.5-169.4-123.7 155.9 18.0 18.9 19.4 67 82 A R E -N 54 0C 49 -13,-2.6 -13,-3.0 -2,-0.3 2,-0.2 -0.975 17.3-128.7-142.5 151.8 17.8 20.2 15.8 68 83 A G E -N 53 0C 24 -2,-0.3 25,-2.5 -15,-0.2 2,-0.5 -0.485 27.8-113.5 -94.0 169.7 17.5 23.6 14.2 69 85 A L E -O 92 0C 14 -17,-0.9 23,-0.2 -20,-0.7 -17,-0.2 -0.924 24.7-178.1-108.7 132.1 14.9 24.6 11.7 70 86 A R E S+ 0 0 157 21,-3.0 2,-0.3 -2,-0.5 22,-0.2 0.803 70.9 4.9 -93.4 -33.4 15.9 25.4 8.1 71 87 A R E -O 91 0C 106 20,-1.1 20,-2.2 -22,-0.1 2,-0.4 -0.996 55.3-152.1-155.9 148.1 12.5 26.3 6.7 72 88 A I E -O 90 0C 36 -2,-0.3 2,-0.5 18,-0.2 18,-0.2 -0.996 10.5-167.9-126.2 128.2 8.8 26.7 7.8 73 89 A I E -O 89 0C 21 16,-3.1 16,-2.5 -2,-0.4 2,-0.3 -0.973 3.8-170.9-120.3 118.0 5.9 26.1 5.5 74 90 A V E -O 88 0C 51 -2,-0.5 14,-0.2 14,-0.2 12,-0.1 -0.840 38.5 -93.1-105.8 143.8 2.4 27.3 6.5 75 91 A H > - 0 0 14 12,-1.9 3,-1.7 -2,-0.3 -1,-0.0 -0.334 29.8-131.5 -58.2 133.6 -0.7 26.3 4.5 76 92 A E T 3 S+ 0 0 116 1,-0.3 -1,-0.1 3,-0.0 -2,-0.0 0.742 105.0 51.5 -56.1 -31.5 -1.6 29.0 1.9 77 93 A K T 3 S+ 0 0 138 8,-0.1 2,-0.3 2,-0.0 -1,-0.3 0.453 82.0 111.8 -89.2 -2.0 -5.2 29.0 3.0 78 94 A Y < + 0 0 29 -3,-1.7 2,-0.3 7,-0.2 7,-0.1 -0.561 41.8 177.6 -73.7 134.6 -4.5 29.5 6.7 79 95 A K > - 0 0 158 5,-0.4 3,-1.8 -2,-0.3 5,-0.2 -0.858 29.3-103.5-144.8 103.4 -5.6 32.9 7.9 80 96 A H T 3 S+ 0 0 108 1,-0.3 3,-0.1 -2,-0.3 -2,-0.0 -0.368 102.2 26.2 -60.9 143.2 -5.3 34.0 11.6 81 97 A P T 3 S+ 0 0 99 0, 0.0 -1,-0.3 0, 0.0 -40,-0.0 -0.971 106.6 87.9 -85.1 5.1 -7.5 34.2 13.7 82 98 A S < - 0 0 67 -3,-1.8 -3,-0.2 1,-0.1 0, 0.0 -0.305 66.2-146.4 -62.3 150.3 -9.5 31.5 11.7 83 99 A H > + 0 0 73 -3,-0.1 3,-0.8 -5,-0.1 -1,-0.1 0.459 58.7 116.4 -97.7 -4.4 -8.7 27.9 12.6 84 100 A D T 3 S+ 0 0 27 1,-0.2 -5,-0.4 -5,-0.2 3,-0.2 -0.363 79.8 12.9 -68.2 144.8 -9.3 26.4 9.2 85 101 A Y T 3 S+ 0 0 38 1,-0.2 2,-2.0 -7,-0.1 -10,-0.3 0.856 78.2 174.6 57.7 39.9 -6.3 24.7 7.4 86 102 A D < + 0 0 0 -3,-0.8 2,-0.3 78,-0.1 -1,-0.2 -0.497 29.9 118.3 -79.5 77.0 -4.3 24.8 10.6 87 103 A I + 0 0 0 -2,-2.0 -12,-1.9 -48,-0.3 2,-0.3 -0.997 33.6 175.3-145.9 144.3 -1.2 22.9 9.4 88 104 A S E -MO 38 74C 0 -50,-2.2 -50,-2.6 -2,-0.3 2,-0.4 -0.960 16.6-146.2-144.2 159.8 2.5 23.6 9.0 89 105 A L E -MO 37 73C 0 -16,-2.5 -16,-3.1 -2,-0.3 2,-0.4 -0.970 10.0-164.4-127.9 142.8 5.7 21.8 8.0 90 106 A A E -MO 36 72C 2 -54,-2.4 -54,-2.4 -2,-0.4 2,-0.5 -0.995 10.5-146.5-132.7 125.3 9.2 22.4 9.3 91 107 A E E -MO 35 71C 27 -20,-2.2 -21,-3.0 -2,-0.4 -20,-1.1 -0.814 22.1-129.9 -91.9 127.6 12.3 21.1 7.7 92 108 A L E - 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