==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=3-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER OXIDOREDUCTASE 31-MAR-07 2PDF . COMPND 2 MOLECULE: ALDOSE REDUCTASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR H.STEUBER,A.HEINE,G.KLEBE . 314 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 13843.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 202 64.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 35 11.1 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 10 3.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 1 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 14 4.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 42 13.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 84 26.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 7 2.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 3 2 1 0 0 2 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 3 2 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 2 A S 0 0 110 0, 0.0 12,-2.6 0, 0.0 13,-0.4 0.000 360.0 360.0 360.0 -15.3 -3.3 15.8 -3.9 2 3 A R E -A 12 0A 134 10,-0.3 2,-0.4 11,-0.1 8,-0.0 -0.913 360.0-145.7-126.5 154.7 -5.8 13.7 -1.9 3 4 A I E -A 11 0A 37 8,-2.6 8,-2.6 -2,-0.3 2,-0.4 -0.947 27.1-114.2-117.1 133.7 -8.5 11.2 -2.7 4 5 A L E -A 10 0A 106 -2,-0.4 6,-0.2 6,-0.2 2,-0.2 -0.517 28.7-152.5 -75.0 122.9 -11.8 10.9 -0.8 5 6 A L > - 0 0 5 4,-3.2 3,-1.8 -2,-0.4 198,-0.1 -0.480 28.9-108.9 -88.3 161.0 -12.3 7.6 1.1 6 7 A N T 3 S+ 0 0 73 1,-0.3 171,-0.1 196,-0.3 -1,-0.1 0.388 116.1 62.2 -78.8 9.6 -15.6 6.1 2.0 7 8 A N T 3 S- 0 0 65 2,-0.2 -1,-0.3 172,-0.1 3,-0.1 0.210 122.1-102.0-107.2 8.9 -15.1 7.0 5.7 8 9 A G S < S+ 0 0 60 -3,-1.8 2,-0.2 1,-0.3 -2,-0.1 0.395 84.8 119.6 88.6 -5.6 -15.1 10.7 4.9 9 10 A A - 0 0 31 144,-0.1 -4,-3.2 95,-0.1 2,-0.5 -0.585 59.6-126.4 -93.3 157.6 -11.3 11.1 5.1 10 11 A K E -A 4 0A 95 -6,-0.2 -6,-0.2 -2,-0.2 -1,-0.0 -0.880 18.8-156.7-107.0 134.5 -8.9 12.2 2.4 11 12 A M E -A 3 0A 1 -8,-2.6 -8,-2.6 -2,-0.5 2,-0.1 -0.930 23.5-115.5-111.0 122.8 -5.9 10.1 1.6 12 13 A P E -A 2 0A 13 0, 0.0 -10,-0.3 0, 0.0 246,-0.1 -0.374 18.5-143.4 -60.1 130.7 -2.7 11.6 -0.1 13 14 A I S S+ 0 0 30 -12,-2.6 245,-2.6 244,-0.1 2,-0.5 0.654 86.4 56.2 -74.1 -14.8 -2.3 10.1 -3.5 14 15 A L B S+b 258 0B 4 -13,-0.4 25,-0.5 243,-0.2 26,-0.5 -0.975 71.1 166.1-119.6 117.3 1.5 10.0 -3.2 15 16 A G E -c 40 0B 0 243,-2.8 2,-0.5 -2,-0.5 26,-0.2 -0.829 36.5-106.3-124.6 172.3 3.0 8.2 -0.3 16 17 A L E -c 41 0B 1 24,-2.4 26,-3.4 -2,-0.3 245,-0.2 -0.859 27.9-146.2 -99.3 122.1 6.4 6.8 0.9 17 18 A G E -cd 42 261B 5 243,-1.8 245,-0.7 -2,-0.5 26,-0.1 -0.532 13.1-174.0 -82.8 152.8 6.9 3.1 0.8 18 19 A T > + 0 0 0 24,-0.6 3,-1.6 -2,-0.2 2,-0.4 0.286 36.6 125.9-135.2 4.3 9.1 1.5 3.6 19 20 A W T 3 S+ 0 0 66 1,-0.3 -2,-0.1 23,-0.1 28,-0.1 -0.607 87.1 11.0 -70.8 127.6 9.5 -2.1 2.7 20 21 A K T 3 S+ 0 0 50 -2,-0.4 -1,-0.3 1,-0.3 28,-0.0 0.493 91.2 135.3 81.2 11.7 13.3 -3.0 2.5 21 22 A S < - 0 0 4 -3,-1.6 -1,-0.3 241,-0.1 5,-0.1 -0.765 55.4-131.9 -85.8 110.8 14.2 0.4 4.1 22 23 A P >> - 0 0 52 0, 0.0 4,-2.6 0, 0.0 3,-2.0 -0.240 12.2-124.0 -63.8 152.9 16.8 -0.6 6.7 23 24 A P H 3> S+ 0 0 64 0, 0.0 4,-0.6 0, 0.0 26,-0.0 0.837 114.2 70.6 -58.9 -28.0 16.4 0.8 10.3 24 25 A G H 34 S+ 0 0 75 1,-0.2 4,-0.0 2,-0.1 -3,-0.0 0.692 119.6 10.4 -45.9 -36.3 19.8 2.1 9.4 25 26 A Q H <> S+ 0 0 98 -3,-2.0 4,-2.2 2,-0.1 -1,-0.2 0.300 104.7 86.9-129.2 -13.6 18.3 4.6 6.9 26 27 A V H X S+ 0 0 0 -4,-2.6 4,-2.3 1,-0.2 5,-0.2 0.855 85.7 57.1 -76.6 -25.4 14.5 4.7 7.3 27 28 A T H X S+ 0 0 24 -4,-0.6 4,-2.3 -5,-0.2 -1,-0.2 0.953 111.4 44.2 -61.4 -48.0 14.5 7.4 10.0 28 29 A E H > S+ 0 0 92 1,-0.2 4,-2.7 2,-0.2 5,-0.3 0.907 111.5 54.0 -63.1 -43.6 16.4 9.7 7.7 29 30 A A H X S+ 0 0 1 -4,-2.2 4,-2.7 1,-0.2 -1,-0.2 0.932 110.8 45.0 -56.8 -44.1 14.2 8.8 4.7 30 31 A V H X S+ 0 0 0 -4,-2.3 4,-2.8 2,-0.2 -1,-0.2 0.924 111.4 53.0 -69.8 -40.9 11.0 9.6 6.6 31 32 A K H X S+ 0 0 39 -4,-2.3 4,-2.4 -5,-0.2 -2,-0.2 0.961 114.4 42.2 -61.3 -47.4 12.4 12.9 8.0 32 33 A V H X S+ 0 0 32 -4,-2.7 4,-2.6 2,-0.2 -1,-0.2 0.902 110.8 55.2 -63.0 -42.0 13.3 14.0 4.5 33 34 A A H X>S+ 0 0 0 -4,-2.7 5,-2.7 -5,-0.3 4,-0.9 0.963 110.8 46.6 -55.1 -48.6 10.1 12.8 2.9 34 35 A I H ><5S+ 0 0 1 -4,-2.8 3,-0.8 1,-0.2 -2,-0.2 0.905 109.6 54.7 -62.6 -41.8 8.2 14.9 5.5 35 36 A D H 3<5S+ 0 0 89 -4,-2.4 -1,-0.2 1,-0.2 -2,-0.2 0.877 111.5 43.8 -59.8 -38.7 10.5 17.9 4.8 36 37 A V H 3<5S- 0 0 58 -4,-2.6 -1,-0.2 -5,-0.1 -2,-0.2 0.553 131.1 -85.9 -90.3 -0.7 9.8 17.8 1.0 37 38 A G T <<5S+ 0 0 21 -4,-0.9 -3,-0.2 -3,-0.8 -2,-0.1 0.391 73.0 143.2 124.1 0.2 6.1 17.3 1.4 38 39 A Y < + 0 0 0 -5,-2.7 -1,-0.3 -6,-0.2 -23,-0.1 -0.517 13.4 170.7 -68.2 142.4 5.1 13.7 1.8 39 40 A R + 0 0 68 -25,-0.5 33,-3.4 -2,-0.1 2,-0.4 0.375 58.8 70.1-122.5 -8.1 2.2 13.2 4.2 40 41 A H E -ce 15 72B 0 -26,-0.5 -24,-2.4 31,-0.2 2,-0.4 -0.956 56.7-176.5-116.2 129.1 1.4 9.5 3.6 41 42 A I E -ce 16 73B 0 31,-1.7 33,-2.1 -2,-0.4 2,-0.6 -0.999 16.5-146.0-128.8 127.4 3.8 6.8 4.8 42 43 A D E +ce 17 74B 3 -26,-3.4 -24,-0.6 -2,-0.4 2,-0.2 -0.869 30.7 167.9 -99.0 124.2 3.1 3.1 4.0 43 44 A C - 0 0 0 31,-2.1 2,-0.3 -2,-0.6 3,-0.1 -0.700 18.6-170.8-126.6 170.2 4.2 0.8 6.8 44 45 A A > - 0 0 0 -2,-0.2 3,-1.7 31,-0.2 5,-0.5 -0.882 31.9-130.2-164.7 140.2 4.0 -2.8 7.9 45 46 A H G > S+ 0 0 32 31,-1.0 3,-2.1 1,-0.3 5,-0.2 0.911 111.4 60.4 -53.0 -43.4 4.9 -4.8 11.0 46 47 A V G 3 S+ 0 0 24 30,-0.3 -1,-0.3 1,-0.3 74,-0.1 0.679 89.6 70.7 -62.4 -13.7 6.5 -7.4 8.7 47 48 A Y G < S- 0 0 37 -3,-1.7 -1,-0.3 1,-0.1 -27,-0.2 0.624 94.2-143.4 -82.4 -9.1 8.9 -4.6 7.4 48 49 A Q S < S+ 0 0 152 -3,-2.1 -3,-0.1 -4,-0.3 -2,-0.1 0.703 78.3 85.6 62.6 26.7 10.7 -4.8 10.8 49 50 A N > + 0 0 1 -5,-0.5 4,-2.1 -27,-0.1 3,-0.2 0.120 42.3 113.3-139.5 11.7 11.3 -1.0 10.8 50 51 A E H > S+ 0 0 3 1,-0.2 4,-2.7 -5,-0.2 5,-0.2 0.885 76.8 58.5 -61.8 -35.1 8.1 0.6 12.3 51 52 A N H > S+ 0 0 60 1,-0.2 4,-2.0 2,-0.2 -1,-0.2 0.937 108.7 45.1 -55.2 -47.4 10.0 1.8 15.5 52 53 A E H > S+ 0 0 56 2,-0.2 4,-1.7 1,-0.2 -1,-0.2 0.822 111.1 51.6 -70.8 -34.6 12.4 3.8 13.3 53 54 A V H X S+ 0 0 0 -4,-2.1 4,-2.3 1,-0.2 3,-0.3 0.975 109.7 52.3 -61.8 -49.9 9.5 5.2 11.2 54 55 A G H X S+ 0 0 0 -4,-2.7 4,-2.7 1,-0.2 5,-0.3 0.840 104.6 56.4 -44.8 -49.4 7.9 6.2 14.5 55 56 A V H X S+ 0 0 64 -4,-2.0 4,-1.9 1,-0.2 -1,-0.2 0.906 108.5 46.4 -57.4 -43.7 11.1 7.9 15.5 56 57 A A H X S+ 0 0 0 -4,-1.7 4,-2.3 -3,-0.3 -2,-0.2 0.925 112.9 48.1 -67.3 -44.2 11.1 10.1 12.5 57 58 A I H X S+ 0 0 2 -4,-2.3 4,-1.9 1,-0.2 5,-0.3 0.951 111.6 50.5 -63.3 -42.7 7.4 11.1 12.8 58 59 A Q H X S+ 0 0 115 -4,-2.7 4,-2.0 -5,-0.2 -1,-0.2 0.928 110.5 49.3 -64.3 -37.5 7.7 11.9 16.4 59 60 A E H X S+ 0 0 70 -4,-1.9 4,-2.7 -5,-0.3 5,-0.2 0.956 110.4 48.5 -66.7 -45.8 10.7 14.1 15.8 60 61 A K H <>S+ 0 0 12 -4,-2.3 5,-2.3 2,-0.2 6,-1.0 0.817 110.2 52.8 -66.4 -26.1 9.1 16.1 13.0 61 62 A L H ><5S+ 0 0 59 -4,-1.9 3,-0.6 3,-0.2 -1,-0.2 0.898 113.0 45.4 -69.2 -43.1 5.9 16.6 15.2 62 63 A R H 3<5S+ 0 0 217 -4,-2.0 -2,-0.2 -5,-0.3 -1,-0.2 0.857 108.1 54.4 -69.0 -38.2 8.1 18.0 17.9 63 64 A E T 3<5S- 0 0 94 -4,-2.7 -1,-0.2 -5,-0.2 -2,-0.2 0.600 113.4-123.7 -69.7 -7.9 10.1 20.2 15.4 64 65 A Q T < 5S+ 0 0 174 -3,-0.6 -3,-0.2 -4,-0.2 -2,-0.1 0.779 74.4 127.7 64.8 31.9 6.7 21.5 14.5 65 66 A V S - 0 0 119 -2,-0.3 3,-1.2 -3,-0.1 4,-0.3 -0.797 31.8-111.6-105.3 159.3 0.8 18.0 12.9 68 69 A R G > S+ 0 0 25 -2,-0.3 3,-2.0 1,-0.3 -1,-0.1 0.857 113.2 61.7 -53.6 -43.3 -0.6 14.6 13.3 69 70 A E G 3 S+ 0 0 139 1,-0.3 -1,-0.3 3,-0.1 -3,-0.0 0.758 101.6 53.7 -61.6 -24.4 -3.9 15.4 11.5 70 71 A E G < S+ 0 0 86 -3,-1.2 2,-0.3 2,-0.0 -1,-0.3 0.528 95.4 84.9 -86.6 -8.4 -2.0 16.2 8.3 71 72 A L < - 0 0 3 -3,-2.0 2,-0.5 -4,-0.3 -31,-0.2 -0.714 62.2-157.7 -96.3 146.5 -0.2 12.8 8.3 72 73 A F E -e 40 0B 8 -33,-3.4 -31,-1.7 -2,-0.3 2,-0.5 -0.917 16.2-171.3-122.5 101.9 -1.9 9.7 6.8 73 74 A I E -e 41 0B 0 -2,-0.5 31,-1.8 -33,-0.2 32,-1.6 -0.861 1.7-171.1-106.6 123.9 -0.2 6.6 8.4 74 75 A V E +ef 42 105B 0 -33,-2.1 -31,-2.1 -2,-0.5 2,-0.3 -0.926 9.0 167.9-111.6 134.3 -1.0 3.2 7.0 75 76 A S E - f 0 106B 0 30,-2.0 32,-1.9 -2,-0.4 2,-0.3 -0.831 20.6-134.1-136.3-178.7 0.0 -0.2 8.4 76 77 A K E - f 0 107B 0 -2,-0.3 -31,-1.0 30,-0.3 2,-0.5 -0.996 15.4-121.1-145.4 135.7 -0.9 -3.8 7.8 77 78 A L E - f 0 108B 0 30,-2.9 32,-1.8 -2,-0.3 33,-0.4 -0.705 38.9-131.1 -74.1 115.0 -1.9 -6.9 9.8 78 79 A W > - 0 0 10 -2,-0.5 3,-1.6 31,-0.1 36,-0.1 -0.264 21.3-105.1 -72.8 162.2 0.7 -9.6 8.9 79 80 A C G > S+ 0 0 0 1,-0.3 35,-2.3 2,-0.1 3,-0.8 0.683 113.7 62.9 -58.8 -28.4 -0.5 -13.1 8.0 80 81 A T G 3 S+ 0 0 1 1,-0.2 37,-0.3 33,-0.2 -1,-0.3 0.349 100.2 55.7 -83.2 5.6 0.4 -14.8 11.3 81 82 A Y G < + 0 0 56 -3,-1.6 -1,-0.2 35,-0.1 9,-0.1 -0.087 66.2 113.9-125.0 26.3 -2.1 -12.7 13.2 82 83 A H < + 0 0 3 -3,-0.8 53,-0.2 32,-0.3 60,-0.1 0.685 46.0 106.4 -78.6 -19.7 -5.3 -13.4 11.3 83 84 A E S >> S- 0 0 42 1,-0.1 3,-2.3 -3,-0.1 4,-1.0 -0.440 80.6-124.5 -61.2 137.8 -6.9 -15.1 14.2 84 85 A K H >> S+ 0 0 95 1,-0.3 3,-0.6 2,-0.2 4,-0.5 0.836 110.0 55.6 -55.0 -35.8 -9.6 -12.8 15.7 85 86 A G H 34 S+ 0 0 78 1,-0.2 -1,-0.3 2,-0.1 4,-0.2 0.583 109.5 47.5 -72.0 -9.2 -7.9 -13.0 19.2 86 87 A L H <> S+ 0 0 68 -3,-2.3 4,-1.9 -5,-0.1 -1,-0.2 0.622 90.0 82.5-104.0 -16.9 -4.6 -11.8 17.8 87 88 A V H S+ 0 0 45 -4,-0.2 4,-2.1 1,-0.2 -1,-0.2 0.921 109.4 49.8 -55.9 -44.6 -2.6 -7.0 19.8 90 91 A A H X S+ 0 0 11 -4,-1.9 4,-1.7 2,-0.2 -1,-0.2 0.924 112.4 47.7 -62.9 -42.0 -1.0 -6.9 16.4 91 92 A C H X S+ 0 0 0 -4,-2.2 4,-2.5 1,-0.2 -2,-0.2 0.900 111.3 50.5 -65.8 -41.2 -2.5 -3.5 15.7 92 93 A Q H X S+ 0 0 94 -4,-2.9 4,-2.4 2,-0.2 -1,-0.2 0.833 106.3 55.2 -71.1 -28.2 -1.4 -2.2 19.1 93 94 A K H X S+ 0 0 97 -4,-2.1 4,-2.8 2,-0.2 5,-0.2 0.904 110.5 46.7 -62.0 -47.4 2.1 -3.4 18.6 94 95 A T H X S+ 0 0 0 -4,-1.7 4,-2.6 -5,-0.2 -2,-0.2 0.925 112.3 50.0 -59.7 -45.3 2.2 -1.4 15.4 95 96 A L H X>S+ 0 0 10 -4,-2.5 5,-1.9 2,-0.2 4,-0.9 0.912 112.5 47.0 -61.1 -43.8 0.7 1.6 17.2 96 97 A S H ><5S+ 0 0 79 -4,-2.4 3,-0.8 2,-0.2 -2,-0.2 0.960 112.9 47.9 -68.0 -46.0 3.3 1.4 20.0 97 98 A D H 3<5S+ 0 0 9 -4,-2.8 -1,-0.2 1,-0.3 -2,-0.2 0.945 114.7 45.9 -57.0 -45.3 6.2 1.0 17.6 98 99 A L H 3<5S- 0 0 1 -4,-2.6 -1,-0.3 -5,-0.2 -2,-0.2 0.625 107.8-129.3 -76.0 -9.9 5.0 3.9 15.5 99 100 A K T <<5 + 0 0 93 -4,-0.9 2,-0.3 -3,-0.8 -3,-0.2 0.810 65.2 130.6 63.8 34.6 4.4 5.9 18.7 100 101 A L < - 0 0 21 -5,-1.9 -1,-0.2 -6,-0.2 3,-0.1 -0.752 59.1-148.8-113.0 157.7 0.9 6.8 17.5 101 102 A D S S+ 0 0 126 1,-0.3 2,-0.3 -2,-0.3 -6,-0.1 0.567 85.3 17.1-105.2 -7.6 -2.5 6.5 19.1 102 103 A Y - 0 0 27 -7,-0.1 2,-0.4 3,-0.0 -1,-0.3 -0.979 64.2-137.2-153.1 156.9 -4.3 5.8 15.8 103 104 A L B -k 152 0C 0 48,-1.6 50,-2.6 -2,-0.3 51,-0.3 -0.885 13.0-144.1-105.8 146.4 -3.7 4.7 12.3 104 105 A D S S+ 0 0 12 -31,-1.8 2,-0.3 -2,-0.4 -30,-0.2 0.815 89.4 10.6 -73.4 -32.8 -5.4 6.4 9.4 105 106 A L E -f 74 0B 1 -32,-1.6 -30,-2.0 48,-0.2 2,-0.4 -0.962 62.2-170.5-151.7 130.6 -5.6 3.1 7.6 106 107 A Y E -fg 75 155B 2 48,-1.8 50,-2.2 -2,-0.3 2,-0.3 -0.992 16.7-163.5-126.3 129.8 -5.0 -0.5 8.6 107 108 A L E -fg 76 156B 0 -32,-1.9 -30,-2.9 -2,-0.4 2,-0.7 -0.845 30.2-118.4-114.9 145.1 -5.0 -3.3 6.0 108 109 A I E -fg 77 157B 1 48,-2.0 50,-1.2 -2,-0.3 -30,-0.1 -0.752 36.6-149.4 -74.1 115.5 -5.3 -7.0 6.0 109 110 A H - 0 0 9 -32,-1.8 -1,-0.2 -2,-0.7 -31,-0.1 0.908 69.7 -0.9 -66.1 -43.9 -1.9 -7.4 4.5 110 111 A W - 0 0 36 -33,-0.4 -1,-0.2 2,-0.1 49,-0.2 -0.966 68.0-124.3-138.7 149.3 -2.5 -10.7 2.5 111 112 A P S S+ 0 0 1 0, 0.0 2,-0.5 0, 0.0 197,-0.1 0.688 87.8 90.7 -69.9 -13.5 -5.8 -12.7 2.3 112 113 A T - 0 0 5 195,-0.1 2,-0.3 23,-0.0 -2,-0.1 -0.728 68.0-146.4 -90.5 122.3 -3.9 -15.8 3.5 113 114 A G - 0 0 0 -2,-0.5 19,-1.8 21,-0.3 2,-0.3 -0.676 15.2-159.7 -82.0 135.8 -3.5 -16.7 7.2 114 115 A F B -L 131 0D 4 -35,-2.3 -32,-0.3 -2,-0.3 18,-0.1 -0.832 37.7 -74.7-111.6 155.0 -0.3 -18.4 8.2 115 116 A K - 0 0 87 15,-3.0 17,-0.2 -2,-0.3 2,-0.1 -0.181 56.1-112.6 -46.4 125.7 0.4 -20.4 11.3 116 117 A P + 0 0 49 0, 0.0 2,-0.3 0, 0.0 -1,-0.1 -0.366 67.3 99.8 -69.8 145.8 0.6 -18.2 14.3 117 118 A G S S- 0 0 27 -37,-0.3 -37,-0.1 1,-0.1 -3,-0.0 -0.953 85.4 -69.6 158.9 176.6 4.0 -18.0 15.9 118 119 A K S S+ 0 0 177 -2,-0.3 2,-0.1 2,-0.0 -1,-0.1 0.901 103.4 86.3 -64.2 -39.9 7.2 -16.0 16.1 119 120 A E - 0 0 125 1,-0.1 -2,-0.1 -3,-0.1 0, 0.0 -0.421 65.0-154.6 -71.9 136.0 8.2 -16.8 12.5 120 121 A F S S+ 0 0 40 1,-0.3 -1,-0.1 -2,-0.1 -41,-0.1 0.837 93.7 32.9 -77.2 -32.3 6.7 -14.5 9.8 121 122 A F S S- 0 0 99 -42,-0.0 2,-0.3 2,-0.0 -1,-0.3 -0.728 80.5-165.9-123.5 75.0 7.0 -17.1 7.1 122 123 A P - 0 0 9 0, 0.0 8,-3.1 0, 0.0 2,-0.3 -0.486 11.7-177.9 -70.0 125.3 6.5 -20.5 8.8 123 124 A L B -M 129 0E 91 -2,-0.3 6,-0.2 6,-0.3 -2,-0.0 -0.877 19.8-127.0-118.5 149.3 7.6 -23.2 6.4 124 125 A D > - 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