==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 16-MAY-07 2PYU . COMPND 2 MOLECULE: INOSINE TRIPHOSPHATE PYROPHOSPHATASE RDGB; . SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; . AUTHOR A.U.SINGER,M.PROUDFOOT,T.SKARINA,A.SAVCHENKO,A.F.YAKUNIN . 208 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 10988.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 138 66.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 9 4.3 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 30 14.4 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 13 6.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 27 13.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 51 24.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 3 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 1 0 0 0 1 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 2 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 -11 A H 0 0 221 0, 0.0 207,-0.1 0, 0.0 2,-0.1 0.000 360.0 360.0 360.0 -44.1 18.3 -27.2 28.1 2 -10 A H - 0 0 73 204,-0.1 4,-0.1 144,-0.0 206,-0.1 0.118 360.0 -99.6 143.5 140.1 14.7 -26.3 27.6 3 -9 A S - 0 0 76 141,-0.2 3,-0.4 1,-0.1 143,-0.0 0.139 40.3 -77.6 -76.4 174.3 11.7 -26.6 29.8 4 -8 A S S S+ 0 0 83 1,-0.2 -1,-0.1 2,-0.1 134,-0.1 -0.206 95.2 50.6 -63.7 151.5 8.7 -28.9 30.1 5 -7 A G S S+ 0 0 34 2,-0.4 -1,-0.2 71,-0.0 -2,-0.1 0.570 73.6 101.4 99.0 13.3 5.6 -29.1 27.9 6 -6 A L S S+ 0 0 11 -3,-0.4 -2,-0.1 1,-0.2 8,-0.1 0.685 91.1 24.1 -95.2 -25.4 7.1 -29.2 24.5 7 -5 A V S S- 0 0 48 6,-0.0 -2,-0.4 31,-0.0 -1,-0.2 -0.976 90.7-104.6-130.3 154.2 6.6 -32.9 24.1 8 -4 A P - 0 0 20 0, 0.0 2,-0.4 0, 0.0 6,-0.1 -0.514 25.2-126.3 -80.1 148.6 4.0 -35.2 25.8 9 -3 A R S S- 0 0 197 -2,-0.2 2,-0.1 28,-0.0 28,-0.0 -0.740 75.1-101.6-118.7 77.5 5.2 -37.6 28.6 10 -2 A G S S+ 0 0 54 -2,-0.4 4,-0.1 2,-0.2 -1,-0.0 -0.923 95.3 67.6 179.0 41.9 3.9 -39.6 26.9 11 -1 A S S S+ 0 0 117 -2,-0.1 26,-0.0 2,-0.1 -2,-0.0 0.766 96.0 69.7 -95.1 -37.2 1.8 -42.3 25.2 12 0 A H S S- 0 0 109 1,-0.1 2,-0.3 0, 0.0 -2,-0.2 -0.131 88.6-110.8 -60.2 164.6 -0.9 -39.7 24.1 13 1 A M - 0 0 105 -6,-0.1 2,-0.5 25,-0.0 25,-0.2 -0.690 18.8-138.7 -94.1 152.8 -0.3 -37.1 21.4 14 2 A Q E -a 38 0A 70 23,-2.9 25,-3.5 -2,-0.3 2,-0.4 -0.985 19.2-134.9-108.6 123.4 -0.1 -33.3 22.3 15 3 A K E -a 39 0A 84 -2,-0.5 2,-0.4 23,-0.2 25,-0.2 -0.660 25.8-177.8 -76.0 134.1 -2.0 -31.2 19.7 16 4 A V E -a 40 0A 0 23,-2.6 25,-2.3 -2,-0.4 2,-0.4 -0.999 21.0-134.5-134.6 129.1 0.0 -28.1 18.6 17 5 A V E -ab 41 77A 0 59,-2.1 61,-2.2 -2,-0.4 2,-0.5 -0.697 13.1-144.4 -86.9 128.4 -1.3 -25.4 16.2 18 6 A L E -ab 42 78A 6 23,-2.8 2,-2.3 -2,-0.4 25,-1.9 -0.868 20.6-124.6 -87.7 127.7 1.1 -24.4 13.5 19 7 A A S S+ 0 0 6 59,-3.2 2,-0.3 -2,-0.5 61,-0.2 -0.288 83.6 65.4 -74.1 60.2 0.7 -20.6 12.7 20 8 A T - 0 0 28 -2,-2.3 23,-1.4 59,-0.1 24,-0.8 -0.941 66.9-143.2-161.0 161.5 0.1 -20.9 9.0 21 9 A G + 0 0 37 -2,-0.3 2,-0.7 22,-0.2 21,-0.1 0.218 61.7 128.9-109.6 6.4 -2.7 -22.4 6.8 22 10 A N > - 0 0 76 1,-0.2 4,-2.2 2,-0.1 5,-0.2 -0.452 48.9-158.2 -65.1 111.1 -0.0 -23.5 4.4 23 11 A V H > S+ 0 0 100 -2,-0.7 4,-3.1 1,-0.2 5,-0.2 0.845 88.3 54.4 -59.5 -38.7 -0.6 -27.2 3.8 24 12 A G H > S+ 0 0 43 2,-0.2 4,-2.7 1,-0.2 -1,-0.2 0.956 111.4 44.5 -59.1 -52.1 3.0 -28.0 2.6 25 13 A K H > S+ 0 0 57 1,-0.2 4,-2.4 2,-0.2 5,-0.2 0.879 115.5 49.3 -57.4 -42.6 4.5 -26.5 5.7 26 14 A V H X S+ 0 0 20 -4,-2.2 4,-3.0 2,-0.2 5,-0.3 0.906 111.4 47.8 -65.5 -45.9 1.9 -28.3 7.9 27 15 A R H X S+ 0 0 189 -4,-3.1 4,-1.9 2,-0.2 -2,-0.2 0.934 114.0 48.4 -56.2 -47.1 2.5 -31.7 6.1 28 16 A E H X S+ 0 0 71 -4,-2.7 4,-1.6 -5,-0.2 -2,-0.2 0.930 118.4 37.9 -61.0 -49.4 6.3 -31.2 6.5 29 17 A L H X S+ 0 0 0 -4,-2.4 4,-2.3 2,-0.2 5,-0.3 0.934 113.8 52.9 -73.3 -44.5 6.2 -30.3 10.2 30 18 A A H X S+ 0 0 27 -4,-3.0 4,-1.3 1,-0.2 -1,-0.2 0.897 111.6 49.8 -55.1 -41.3 3.4 -32.7 11.2 31 19 A S H < S+ 0 0 81 -4,-1.9 4,-0.4 -5,-0.3 -1,-0.2 0.856 112.7 45.3 -66.2 -38.0 5.4 -35.5 9.6 32 20 A L H < S+ 0 0 55 -4,-1.6 -1,-0.2 1,-0.2 -2,-0.2 0.810 120.0 38.5 -74.0 -34.1 8.7 -34.6 11.4 33 21 A L H ><>S+ 0 0 0 -4,-2.3 5,-2.0 1,-0.2 3,-1.1 0.539 90.1 90.5 -99.2 -15.4 7.2 -34.1 14.9 34 22 A S G ><5S+ 0 0 61 -4,-1.3 3,-2.6 -5,-0.3 -1,-0.2 0.926 85.5 54.2 -39.7 -56.0 4.7 -37.0 14.7 35 23 A D G 3 5S+ 0 0 148 -4,-0.4 -1,-0.3 1,-0.3 -2,-0.1 0.716 102.0 57.6 -60.6 -26.8 7.4 -39.2 16.2 36 24 A F G < 5S- 0 0 36 -3,-1.1 -1,-0.3 2,-0.1 -2,-0.2 0.294 124.5-102.4 -84.4 3.8 7.8 -36.9 19.2 37 25 A G T < 5S+ 0 0 8 -3,-2.6 -23,-2.9 1,-0.3 2,-0.5 0.672 75.7 141.4 85.9 17.7 4.1 -37.3 19.9 38 26 A L E < -a 14 0A 3 -5,-2.0 2,-0.9 -25,-0.2 -1,-0.3 -0.844 41.1-155.2-103.0 129.1 3.1 -33.9 18.5 39 27 A D E -a 15 0A 60 -25,-3.5 -23,-2.6 -2,-0.5 2,-0.4 -0.860 20.0-157.3-102.5 97.8 -0.2 -33.7 16.6 40 28 A I E +a 16 0A 13 -2,-0.9 2,-0.4 -25,-0.2 -23,-0.2 -0.699 14.6 178.8 -89.8 130.7 0.4 -30.6 14.3 41 29 A V E -a 17 0A 17 -25,-2.3 -23,-2.8 -2,-0.4 2,-0.1 -0.979 31.5-111.0-134.3 136.4 -2.7 -28.8 13.0 42 30 A A E > -a 18 0A 6 -2,-0.4 4,-0.8 -25,-0.2 3,-0.4 -0.359 22.3-130.0 -61.2 142.8 -2.9 -25.7 10.8 43 31 A Q T 4>S+ 0 0 14 -25,-1.9 5,-2.7 -23,-1.4 3,-0.3 0.795 107.9 64.3 -65.9 -25.9 -4.2 -22.6 12.6 44 32 A T T >45S+ 0 0 74 -24,-0.8 3,-2.1 -26,-0.2 -1,-0.2 0.905 94.2 58.8 -65.6 -39.5 -6.7 -22.3 9.7 45 33 A D T 345S+ 0 0 118 -3,-0.4 -1,-0.2 1,-0.3 -2,-0.2 0.811 107.5 48.8 -54.9 -31.1 -8.4 -25.6 10.6 46 34 A L T 3<5S- 0 0 74 -4,-0.8 -1,-0.3 -3,-0.3 -2,-0.2 0.148 123.3-105.5 -97.1 13.6 -9.1 -24.1 14.0 47 35 A G T < 5 + 0 0 55 -3,-2.1 2,-0.5 1,-0.2 -3,-0.2 0.640 63.8 156.9 77.0 16.7 -10.5 -20.9 12.6 48 36 A V < - 0 0 5 -5,-2.7 -1,-0.2 -6,-0.1 2,-0.1 -0.609 30.0-147.6 -77.2 123.9 -7.5 -18.6 13.4 49 37 A D - 0 0 134 -2,-0.5 -1,-0.0 1,-0.1 -6,-0.0 -0.443 36.6 -77.5 -77.7 161.9 -7.3 -15.5 11.2 50 38 A S - 0 0 108 -2,-0.1 2,-0.3 1,-0.1 -1,-0.1 -0.326 45.0-129.9 -56.5 135.9 -3.9 -14.0 10.2 51 39 A A - 0 0 25 -3,-0.1 2,-0.5 1,-0.0 -1,-0.1 -0.683 25.9-105.1 -79.1 146.6 -2.1 -12.0 12.8 52 40 A E - 0 0 161 -2,-0.3 2,-1.5 12,-0.1 3,-0.1 -0.597 28.1-135.9 -69.0 116.9 -0.8 -8.6 12.0 53 41 A E + 0 0 79 -2,-0.5 8,-0.1 1,-0.2 -1,-0.1 -0.597 44.3 152.5 -87.3 92.3 3.0 -8.8 11.7 54 42 A T + 0 0 104 -2,-1.5 -1,-0.2 6,-0.1 2,-0.1 0.370 32.3 108.0-101.0 -2.5 4.0 -5.7 13.6 55 43 A G - 0 0 8 -3,-0.1 6,-0.0 1,-0.1 -2,-0.0 -0.377 62.0-142.0 -85.3 161.6 7.5 -6.7 14.8 56 44 A L S S+ 0 0 127 -2,-0.1 2,-0.3 38,-0.0 39,-0.3 0.437 82.9 48.5-103.1 3.5 10.7 -5.3 13.6 57 45 A T S > S- 0 0 64 1,-0.1 4,-2.4 38,-0.1 5,-0.2 -0.921 83.9-116.5-134.9 157.8 12.6 -8.7 13.7 58 46 A F H > S+ 0 0 27 -2,-0.3 4,-2.6 1,-0.2 5,-0.3 0.943 118.0 53.2 -60.0 -45.2 12.0 -12.2 12.4 59 47 A I H > S+ 0 0 69 1,-0.2 4,-2.5 2,-0.2 5,-0.3 0.931 109.2 48.3 -59.0 -46.1 12.0 -13.4 16.1 60 48 A E H > S+ 0 0 93 1,-0.2 4,-2.4 2,-0.2 -1,-0.2 0.934 114.1 46.2 -61.7 -44.5 9.4 -10.8 17.1 61 49 A N H X S+ 0 0 2 -4,-2.4 4,-2.2 2,-0.2 -1,-0.2 0.899 111.9 50.6 -61.4 -41.6 7.1 -11.6 14.2 62 50 A A H X S+ 0 0 0 -4,-2.6 4,-2.0 1,-0.2 -2,-0.2 0.906 113.6 46.2 -66.1 -40.3 7.4 -15.5 14.8 63 51 A I H X S+ 0 0 34 -4,-2.5 4,-2.9 -5,-0.3 5,-0.2 0.917 110.7 51.8 -67.3 -41.8 6.6 -14.9 18.4 64 52 A L H X S+ 0 0 50 -4,-2.4 4,-1.8 -5,-0.3 -1,-0.2 0.879 112.8 46.4 -61.1 -40.4 3.6 -12.6 17.6 65 53 A K H X S+ 0 0 34 -4,-2.2 4,-2.1 2,-0.2 -1,-0.2 0.882 112.8 47.9 -70.1 -36.9 2.2 -15.2 15.2 66 54 A A H X S+ 0 0 0 -4,-2.0 4,-2.1 2,-0.2 -2,-0.2 0.904 111.4 51.5 -70.4 -44.6 2.7 -18.1 17.6 67 55 A R H X S+ 0 0 102 -4,-2.9 4,-2.4 2,-0.2 5,-0.2 0.887 108.6 50.9 -59.1 -41.8 1.1 -16.1 20.5 68 56 A H H X S+ 0 0 58 -4,-1.8 4,-2.4 -5,-0.2 5,-0.2 0.944 112.8 45.1 -62.6 -52.5 -2.0 -15.2 18.4 69 57 A A H X S+ 0 0 0 -4,-2.1 4,-1.8 1,-0.2 6,-0.4 0.878 115.1 47.7 -56.6 -43.9 -2.6 -18.8 17.4 70 58 A A H X S+ 0 0 2 -4,-2.1 4,-2.2 2,-0.2 5,-0.4 0.871 112.3 50.9 -65.4 -38.8 -2.0 -20.1 20.9 71 59 A K H < S+ 0 0 159 -4,-2.4 -2,-0.2 -5,-0.2 -3,-0.2 0.940 114.4 41.7 -69.1 -37.8 -4.4 -17.4 22.4 72 60 A V H < S+ 0 0 78 -4,-2.4 -1,-0.2 -5,-0.2 -2,-0.2 0.802 127.1 31.4 -80.4 -26.3 -7.3 -18.2 20.0 73 61 A T H < S- 0 0 30 -4,-1.8 -2,-0.2 -5,-0.2 -1,-0.2 0.596 93.4-132.5-103.1 -21.7 -7.0 -22.0 20.2 74 62 A A S < S+ 0 0 94 -4,-2.2 -3,-0.1 1,-0.3 -4,-0.1 0.726 70.0 120.2 63.4 26.2 -5.7 -22.4 23.8 75 63 A L S S- 0 0 28 -6,-0.4 -1,-0.3 -5,-0.4 -2,-0.2 -0.796 77.3 -95.7-110.3 158.4 -3.1 -24.8 22.3 76 64 A P - 0 0 13 0, 0.0 -59,-2.1 0, 0.0 2,-0.4 -0.380 52.2-146.9 -62.0 154.3 0.7 -24.7 22.4 77 65 A A E -bC 17 137A 0 60,-2.6 60,-3.0 -61,-0.2 2,-0.4 -0.989 21.3-160.3-141.0 139.2 1.8 -23.0 19.1 78 66 A I E +bC 18 136A 0 -61,-2.2 -59,-3.2 -2,-0.4 2,-0.3 -0.945 20.9 170.4-109.3 137.3 4.7 -23.2 16.6 79 67 A A E - C 0 135A 0 56,-2.0 56,-3.0 -2,-0.4 2,-0.3 -0.974 15.7-155.9-138.6 161.8 5.3 -20.3 14.1 80 68 A D E - C 0 134A 9 -2,-0.3 2,-0.3 -61,-0.2 54,-0.2 -0.818 3.6-167.4-126.2 161.5 8.1 -19.3 11.7 81 69 A A E + C 0 133A 6 52,-1.3 52,-3.3 -2,-0.3 2,-0.3 -0.923 18.9 171.7-144.8 136.0 9.2 -16.0 10.3 82 70 A S E + C 0 132A 49 -2,-0.3 2,-0.3 50,-0.2 50,-0.2 -0.940 7.5 135.7-141.5 160.8 11.6 -15.9 7.3 83 71 A G E - C 0 131A 9 48,-1.7 48,-2.8 -2,-0.3 2,-0.4 -0.974 49.2 -82.5 174.1-176.7 13.1 -13.4 4.8 84 72 A L E - C 0 130A 0 10,-0.4 10,-2.9 -2,-0.3 2,-0.5 -0.937 32.6-164.8-112.3 133.3 16.2 -12.2 3.0 85 73 A A E -DC 93 129A 12 44,-2.7 44,-1.9 -2,-0.4 2,-0.5 -0.981 4.5-158.4-124.7 117.2 18.6 -9.8 4.8 86 74 A V E > > - C 0 128A 0 6,-2.8 5,-2.6 -2,-0.5 3,-1.1 -0.861 10.5-146.0 -99.6 123.5 21.3 -8.0 2.7 87 75 A D G > 5S+ 0 0 102 40,-1.5 3,-2.0 -2,-0.5 -1,-0.1 0.895 97.1 49.9 -55.0 -53.3 24.3 -6.8 4.6 88 76 A V G 3 5S+ 0 0 65 39,-0.5 -1,-0.3 37,-0.4 38,-0.1 0.763 110.4 53.1 -60.6 -19.3 25.0 -3.6 2.6 89 77 A L G X 5S- 0 0 47 -3,-1.1 3,-1.2 3,-0.3 -1,-0.3 0.099 121.0-106.9-102.3 20.6 21.3 -2.6 3.0 90 78 A G T < 5S- 0 0 79 -3,-2.0 -3,-0.2 1,-0.2 -2,-0.1 0.705 82.2 -43.4 60.4 24.4 21.4 -3.1 6.8 91 79 A G T 3 S+D 85 0A 2 0, 0.0 3,-2.3 0, 0.0 -1,-0.3 -0.919 92.4 133.5 -62.7 -28.8 14.4 -6.4 2.7 94 82 A G G > S+ 0 0 9 -10,-2.9 3,-1.8 1,-0.3 -10,-0.4 -0.371 80.1 2.3 65.8-134.7 14.3 -8.1 6.1 95 83 A I G 3 S+ 0 0 23 -39,-0.3 -1,-0.3 1,-0.3 3,-0.3 0.584 133.1 60.4 -64.9 -9.4 10.9 -8.2 7.7 96 84 A Y G X S+ 0 0 115 -3,-2.3 3,-0.5 1,-0.2 4,-0.3 0.267 70.5 115.5 -97.5 13.3 9.6 -6.5 4.5 97 85 A S G X S+ 0 0 9 -3,-1.8 3,-0.9 1,-0.2 4,-0.2 0.872 78.2 41.6 -48.5 -50.4 10.7 -9.4 2.3 98 86 A A G 3 S+ 0 0 86 -3,-0.3 -1,-0.2 1,-0.2 3,-0.2 0.833 127.4 32.5 -73.1 -22.7 7.2 -10.5 1.2 99 87 A R G X S+ 0 0 104 -3,-0.5 3,-2.4 1,-0.1 -1,-0.2 0.029 78.3 129.5-122.1 21.4 6.0 -6.9 0.7 100 88 A Y T < S+ 0 0 30 -3,-0.9 -1,-0.1 -4,-0.3 -2,-0.1 0.824 77.8 41.7 -58.7 -37.5 9.2 -5.3 -0.4 101 89 A S T 3 S- 0 0 35 1,-0.3 -1,-0.3 -4,-0.2 2,-0.2 0.197 115.7-121.6 -99.1 18.2 7.8 -3.6 -3.5 102 90 A G X + 0 0 36 -3,-2.4 3,-1.3 -6,-0.2 -1,-0.3 -0.536 63.1 6.7 96.7-151.8 4.7 -2.6 -1.7 103 91 A E T 3 S+ 0 0 172 1,-0.3 -4,-0.0 -2,-0.2 0, 0.0 -0.521 133.4 23.3 -72.3 139.3 1.0 -3.1 -2.1 104 92 A D T 3 S+ 0 0 123 -2,-0.2 -1,-0.3 1,-0.2 2,-0.1 0.831 89.6 170.0 66.1 26.1 0.5 -5.6 -4.9 105 93 A A < - 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