==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=31-JUL-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE/HYDROLASE INHIBITOR 13-JUN-11 3SFF . COMPND 2 MOLECULE: HISTONE DEACETYLASE 8; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR T.STAMS,B.VASH . 341 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 14197.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 237 69.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 39 11.4 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 6 1.8 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 21 6.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 43 12.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 110 32.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 3 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 1 0 1 1 1 1 1 0 1 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 1 1 1 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 14 A L 0 0 153 0, 0.0 95,-0.1 0, 0.0 96,-0.1 0.000 360.0 360.0 360.0 179.1 -20.7 16.4 -8.9 2 15 A V - 0 0 68 93,-0.3 96,-0.2 1,-0.1 39,-0.1 -0.654 360.0-110.1 -77.6 131.6 -18.0 19.0 -8.0 3 16 A P - 0 0 13 0, 0.0 39,-3.2 0, 0.0 2,-0.4 -0.319 24.4-123.2 -65.8 148.9 -14.6 18.1 -9.8 4 17 A V E -ab 42 99A 0 94,-2.6 96,-2.7 37,-0.2 2,-0.6 -0.795 21.8-160.9 -91.0 129.9 -11.7 16.8 -7.7 5 18 A Y E -ab 43 100A 10 37,-2.7 39,-2.6 -2,-0.4 2,-0.6 -0.975 13.3-140.2-114.7 113.1 -8.5 19.0 -8.1 6 19 A I E +a 44 0A 8 94,-2.9 2,-0.3 -2,-0.6 96,-0.3 -0.703 47.1 135.1 -78.8 115.4 -5.3 17.1 -7.0 7 20 A Y + 0 0 48 37,-2.0 -2,-0.1 -2,-0.6 3,-0.1 -0.971 24.1 155.8-163.2 147.5 -3.2 19.7 -5.2 8 21 A S > - 0 0 10 -2,-0.3 4,-2.0 37,-0.2 3,-0.2 -0.877 47.2-118.3-162.4 147.0 -1.0 20.5 -2.1 9 22 A P H > S+ 0 0 72 0, 0.0 4,-2.4 0, 0.0 5,-0.1 0.864 116.9 54.5 -61.4 -31.6 1.7 23.2 -2.0 10 23 A E H > S+ 0 0 164 2,-0.2 4,-1.9 1,-0.2 5,-0.1 0.863 107.9 49.1 -63.9 -42.6 4.3 20.4 -1.3 11 24 A Y H > S+ 0 0 12 -3,-0.2 4,-2.3 2,-0.2 -1,-0.2 0.914 113.7 45.8 -63.8 -45.4 3.2 18.5 -4.5 12 25 A V H X S+ 0 0 13 -4,-2.0 4,-2.0 2,-0.2 14,-0.2 0.916 111.8 50.8 -64.9 -43.8 3.5 21.7 -6.6 13 26 A S H X S+ 0 0 71 -4,-2.4 4,-0.5 2,-0.2 -1,-0.2 0.859 111.8 48.9 -60.7 -40.8 6.9 22.7 -5.1 14 27 A M H >< S+ 0 0 67 -4,-1.9 3,-1.3 1,-0.2 -2,-0.2 0.944 112.2 47.1 -63.7 -51.3 8.2 19.1 -5.8 15 28 A C H >< S+ 0 0 4 -4,-2.3 3,-1.6 1,-0.3 9,-0.2 0.784 101.0 66.9 -63.0 -28.9 6.9 19.2 -9.5 16 29 A D H 3< S+ 0 0 25 -4,-2.0 7,-1.6 1,-0.3 -1,-0.3 0.776 94.0 60.6 -60.7 -29.0 8.4 22.7 -10.0 17 30 A S T << S+ 0 0 75 -3,-1.3 -1,-0.3 -4,-0.5 2,-0.2 0.311 76.4 124.4 -84.0 6.9 11.9 21.1 -9.6 18 31 A L X - 0 0 18 -3,-1.6 3,-0.6 3,-0.3 6,-0.2 -0.530 68.3-115.7 -73.9 133.8 11.4 18.8 -12.7 19 32 A A T 3 S+ 0 0 77 1,-0.2 -1,-0.1 -2,-0.2 98,-0.0 0.811 99.8 20.8 -32.4 -79.6 14.1 19.2 -15.4 20 33 A K T 3 S+ 0 0 113 1,-0.2 -1,-0.2 97,-0.1 -2,-0.0 0.519 124.0 55.0 -82.4 -3.7 12.7 20.6 -18.7 21 34 A I S X S- 0 0 11 -3,-0.6 3,-1.7 -6,-0.1 4,-0.4 -0.452 72.9-178.0-124.2 54.8 9.5 22.1 -17.0 22 35 A P T 3 S- 0 0 71 0, 0.0 -5,-0.2 0, 0.0 -6,-0.1 -0.388 73.8 -6.7 -65.9 130.3 10.8 24.5 -14.2 23 36 A K T 3> S+ 0 0 113 -7,-1.6 4,-2.0 -10,-0.1 -7,-0.2 0.527 94.9 127.8 65.9 10.6 8.1 26.2 -12.2 24 37 A R H <> + 0 0 7 -3,-1.7 4,-2.2 -9,-0.2 5,-0.2 0.895 68.8 52.5 -63.8 -41.6 5.4 24.8 -14.6 25 38 A A H > S+ 0 0 10 -4,-0.4 4,-2.4 -13,-0.2 -1,-0.2 0.880 111.9 46.4 -61.6 -37.9 3.3 23.3 -11.8 26 39 A S H > S+ 0 0 22 -14,-0.2 4,-2.7 2,-0.2 -1,-0.2 0.847 111.4 52.1 -70.2 -38.6 3.2 26.7 -9.9 27 40 A M H X S+ 0 0 13 -4,-2.0 4,-1.5 2,-0.2 -2,-0.2 0.909 113.0 43.8 -64.4 -43.2 2.4 28.5 -13.2 28 41 A V H X S+ 0 0 5 -4,-2.2 4,-2.0 2,-0.2 -2,-0.2 0.949 117.9 44.0 -66.8 -52.7 -0.6 26.2 -13.9 29 42 A H H X S+ 0 0 18 -4,-2.4 4,-2.3 1,-0.2 -2,-0.2 0.898 113.6 49.8 -61.7 -45.4 -1.9 26.2 -10.3 30 43 A S H X S+ 0 0 7 -4,-2.7 4,-2.0 2,-0.2 -1,-0.2 0.798 111.2 49.2 -68.3 -27.0 -1.5 30.0 -9.8 31 44 A L H X S+ 0 0 0 -4,-1.5 4,-1.4 2,-0.2 -1,-0.2 0.905 112.4 47.4 -74.9 -41.7 -3.3 30.8 -13.1 32 45 A I H <>S+ 0 0 0 -4,-2.0 5,-2.2 2,-0.2 6,-0.5 0.876 115.8 47.0 -59.3 -42.1 -6.2 28.4 -12.2 33 46 A E H ><5S+ 0 0 94 -4,-2.3 3,-1.4 3,-0.2 -2,-0.2 0.876 107.3 55.8 -69.4 -39.0 -6.2 30.2 -8.7 34 47 A A H 3<5S+ 0 0 31 -4,-2.0 -1,-0.2 1,-0.3 -2,-0.2 0.765 108.3 48.1 -64.2 -30.8 -6.1 33.7 -10.3 35 48 A Y T 3<5S- 0 0 15 -4,-1.4 -1,-0.3 -3,-0.1 -2,-0.2 0.346 114.4-123.5 -88.8 -0.4 -9.3 32.8 -12.3 36 49 A A T X 5 + 0 0 29 -3,-1.4 3,-0.8 -5,-0.1 4,-0.3 0.672 68.2 137.3 61.1 29.7 -10.8 31.6 -8.9 37 50 A L G > < + 0 0 0 -5,-2.2 3,-1.2 1,-0.2 -4,-0.2 0.776 59.6 67.3 -72.4 -30.5 -11.5 28.0 -10.4 38 51 A H G > S+ 0 0 48 -6,-0.5 3,-1.1 1,-0.3 -1,-0.2 0.725 91.7 62.8 -60.6 -28.3 -10.2 26.2 -7.3 39 52 A K G < S+ 0 0 167 -3,-0.8 -1,-0.3 1,-0.2 -2,-0.2 0.706 102.2 51.3 -68.9 -26.4 -13.3 27.7 -5.4 40 53 A Q G < S+ 0 0 74 -3,-1.2 2,-0.3 -4,-0.3 -1,-0.2 0.249 109.5 64.5 -93.1 10.2 -15.5 25.7 -7.9 41 54 A M S < S- 0 0 14 -3,-1.1 2,-0.7 -39,-0.1 -37,-0.2 -0.879 84.6-109.5-132.5 162.9 -13.6 22.4 -7.2 42 55 A R E -a 4 0A 129 -39,-3.2 -37,-2.7 -2,-0.3 2,-0.5 -0.840 33.4-142.1 -95.2 107.6 -12.8 19.9 -4.3 43 56 A I E -a 5 0A 76 -2,-0.7 2,-0.5 -39,-0.2 -37,-0.2 -0.588 22.1-174.3 -72.6 117.8 -9.1 20.3 -3.3 44 57 A V E -a 6 0A 26 -39,-2.6 -37,-2.0 -2,-0.5 43,-0.0 -0.981 21.6-129.5-119.2 125.6 -7.8 16.8 -2.6 45 58 A K - 0 0 137 -2,-0.5 2,-0.2 -39,-0.2 -37,-0.2 -0.492 28.0-120.0 -68.9 132.6 -4.2 16.4 -1.1 46 59 A P - 0 0 24 0, 0.0 2,-0.3 0, 0.0 37,-0.2 -0.502 18.9-140.5 -75.3 141.9 -2.1 13.8 -3.1 47 60 A K - 0 0 160 35,-0.6 2,-0.3 -2,-0.2 39,-0.2 -0.747 25.4-111.8 -92.9 146.2 -0.9 10.7 -1.1 48 61 A V - 0 0 103 -2,-0.3 31,-0.2 34,-0.1 2,-0.1 -0.659 38.7-108.6 -78.2 137.7 2.7 9.6 -2.0 49 62 A A - 0 0 6 29,-2.9 2,-0.2 -2,-0.3 33,-0.1 -0.437 30.2-132.1 -70.2 139.9 2.6 6.1 -3.8 50 63 A S > - 0 0 43 -2,-0.1 4,-2.2 1,-0.1 5,-0.2 -0.478 25.9-105.5 -82.0 165.0 3.9 3.2 -1.7 51 64 A M H > S+ 0 0 49 1,-0.2 4,-2.0 2,-0.2 -1,-0.1 0.878 122.5 52.1 -56.7 -40.0 6.4 0.7 -3.1 52 65 A E H 4 S+ 0 0 142 2,-0.2 -1,-0.2 1,-0.2 4,-0.1 0.868 107.8 49.6 -66.4 -41.6 3.5 -1.9 -3.5 53 66 A E H >4 S+ 0 0 52 2,-0.2 3,-1.3 1,-0.2 4,-0.2 0.911 113.3 46.4 -66.6 -39.1 1.2 0.5 -5.4 54 67 A M H >X S+ 0 0 2 -4,-2.2 4,-2.4 1,-0.3 3,-1.5 0.892 106.9 60.3 -69.2 -32.0 4.1 1.4 -7.9 55 68 A A T 3< S+ 0 0 33 -4,-2.0 -1,-0.3 1,-0.3 -2,-0.2 0.423 79.0 85.4 -75.5 1.5 4.8 -2.4 -8.1 56 69 A T T <4 S+ 0 0 83 -3,-1.3 -1,-0.3 -4,-0.1 -2,-0.2 0.708 120.2 2.1 -72.4 -19.4 1.3 -3.0 -9.5 57 70 A F T <4 S+ 0 0 13 -3,-1.5 -2,-0.2 -4,-0.2 -3,-0.1 0.606 122.9 70.3-126.4 -55.0 3.0 -2.1 -12.8 58 71 A H S < S- 0 0 3 -4,-2.4 54,-0.2 1,-0.1 -1,-0.2 -0.390 83.1-110.4 -74.8 146.8 6.7 -1.5 -12.3 59 72 A T > - 0 0 43 52,-2.0 4,-2.3 1,-0.1 5,-0.2 -0.398 20.2-123.4 -71.4 155.0 9.1 -4.4 -11.4 60 73 A D H > S+ 0 0 91 2,-0.2 4,-2.8 1,-0.2 5,-0.2 0.935 113.4 52.2 -63.0 -44.2 10.7 -4.4 -8.0 61 74 A A H > S+ 0 0 73 1,-0.2 4,-2.7 2,-0.2 -1,-0.2 0.888 110.4 47.4 -57.9 -45.0 14.2 -4.4 -9.6 62 75 A Y H > S+ 0 0 16 2,-0.2 4,-2.3 1,-0.2 -1,-0.2 0.931 113.1 48.4 -64.7 -42.0 13.4 -1.4 -11.7 63 76 A L H X S+ 0 0 0 -4,-2.3 4,-1.8 2,-0.2 -2,-0.2 0.909 113.4 47.2 -62.1 -40.9 11.9 0.5 -8.6 64 77 A Q H X S+ 0 0 98 -4,-2.8 4,-1.8 1,-0.2 -2,-0.2 0.908 111.3 52.5 -66.3 -38.4 15.0 -0.5 -6.6 65 78 A H H X S+ 0 0 105 -4,-2.7 4,-1.9 1,-0.2 -2,-0.2 0.874 106.3 53.4 -63.3 -39.6 17.1 0.8 -9.6 66 79 A L H X S+ 0 0 0 -4,-2.3 4,-1.2 2,-0.2 8,-0.5 0.900 106.5 52.5 -61.9 -39.4 15.2 4.1 -9.5 67 80 A Q H < S+ 0 0 93 -4,-1.8 3,-0.3 1,-0.2 -2,-0.2 0.908 111.2 46.8 -60.5 -47.5 16.1 4.5 -5.8 68 81 A K H < S+ 0 0 179 -4,-1.8 -1,-0.2 1,-0.2 -2,-0.2 0.793 110.4 51.4 -66.2 -36.8 19.8 4.0 -6.5 69 82 A V H < 0 0 79 -4,-1.9 -1,-0.2 -5,-0.1 -2,-0.2 0.719 360.0 360.0 -74.6 -20.1 19.9 6.4 -9.5 70 83 A S < 0 0 55 -4,-1.2 -4,-0.0 -3,-0.3 -3,-0.0 -0.560 360.0 360.0 -74.0 360.0 18.2 9.1 -7.3 71 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 72 107 A G >> 0 0 52 0, 0.0 4,-1.4 0, 0.0 3,-0.6 0.000 360.0 360.0 360.0 11.1 15.9 12.5 -6.2 73 108 A I H 3> + 0 0 41 1,-0.2 4,-2.5 2,-0.2 5,-0.2 0.821 360.0 61.2 -59.7 -36.2 13.9 11.0 -9.1 74 109 A F H 3> S+ 0 0 30 -8,-0.5 4,-2.4 1,-0.2 -1,-0.2 0.880 105.0 48.9 -59.5 -40.0 12.4 8.2 -7.0 75 110 A D H <> S+ 0 0 94 -3,-0.6 4,-2.0 2,-0.2 -1,-0.2 0.905 111.9 46.8 -68.0 -43.6 10.7 10.8 -4.8 76 111 A Y H X S+ 0 0 58 -4,-1.4 4,-2.5 2,-0.2 5,-0.2 0.901 114.3 50.2 -60.1 -44.2 9.2 12.8 -7.8 77 112 A A H X S+ 0 0 8 -4,-2.5 4,-2.7 1,-0.2 5,-0.3 0.926 111.8 45.3 -60.1 -50.1 8.1 9.5 -9.3 78 113 A A H X S+ 0 0 4 -4,-2.4 -29,-2.9 2,-0.2 4,-1.7 0.822 114.3 49.9 -64.2 -36.3 6.3 8.3 -6.1 79 114 A A H X S+ 0 0 9 -4,-2.0 4,-1.7 -31,-0.2 -2,-0.2 0.918 115.2 41.7 -71.0 -44.9 4.7 11.8 -5.6 80 115 A I H X S+ 0 0 10 -4,-2.5 4,-1.9 2,-0.2 -2,-0.2 0.904 116.7 47.7 -68.8 -45.0 3.3 12.0 -9.2 81 116 A G H X S+ 0 0 0 -4,-2.7 4,-2.6 -5,-0.2 -2,-0.2 0.919 112.7 51.0 -61.8 -39.2 2.2 8.3 -9.3 82 117 A G H X S+ 0 0 2 -4,-1.7 4,-2.3 -5,-0.3 -35,-0.6 0.847 106.8 53.0 -64.0 -40.6 0.6 8.9 -5.9 83 118 A A H X S+ 0 0 0 -4,-1.7 4,-1.6 2,-0.2 -1,-0.2 0.876 111.5 46.1 -64.9 -39.0 -1.3 12.0 -7.2 84 119 A T H X S+ 0 0 0 -4,-1.9 4,-2.2 2,-0.2 -2,-0.2 0.921 111.9 50.8 -70.8 -41.4 -2.7 10.0 -10.1 85 120 A I H X S+ 0 0 6 -4,-2.6 4,-2.4 1,-0.2 -2,-0.2 0.893 108.2 53.3 -61.2 -41.0 -3.7 7.0 -7.8 86 121 A T H X S+ 0 0 15 -4,-2.3 4,-2.2 -39,-0.2 -1,-0.2 0.889 108.1 49.9 -60.3 -41.9 -5.4 9.5 -5.5 87 122 A A H X S+ 0 0 0 -4,-1.6 4,-2.0 2,-0.2 -2,-0.2 0.915 111.4 48.5 -64.4 -42.8 -7.5 10.9 -8.4 88 123 A A H X S+ 0 0 0 -4,-2.2 4,-2.1 1,-0.2 -2,-0.2 0.879 110.8 52.1 -62.3 -39.4 -8.4 7.3 -9.4 89 124 A Q H X S+ 0 0 41 -4,-2.4 4,-2.5 2,-0.2 -2,-0.2 0.894 107.0 51.2 -64.4 -43.6 -9.4 6.6 -5.7 90 125 A C H <>S+ 0 0 7 -4,-2.2 5,-2.0 1,-0.2 6,-0.6 0.932 112.7 47.4 -60.0 -41.8 -11.7 9.7 -5.6 91 126 A L H ><5S+ 0 0 4 -4,-2.0 3,-0.9 1,-0.2 -2,-0.2 0.864 111.7 49.7 -63.3 -42.7 -13.4 8.4 -8.8 92 127 A I H 3<5S+ 0 0 19 -4,-2.1 -2,-0.2 1,-0.2 -1,-0.2 0.903 110.2 51.2 -60.3 -46.3 -13.7 4.8 -7.3 93 128 A D T 3<5S- 0 0 108 -4,-2.5 -1,-0.2 -5,-0.1 -2,-0.2 0.366 112.8-118.4 -76.0 -0.9 -15.3 6.1 -4.1 94 129 A G T < 5S+ 0 0 49 -3,-0.9 -3,-0.2 -4,-0.3 -2,-0.1 0.618 73.9 133.1 69.5 18.6 -17.9 8.2 -6.0 95 130 A M S + c 0 266A 0 164,-2.7 3,-1.9 -2,-0.4 166,-1.2 -0.778 6.9 178.0-131.4 82.7 -3.9 15.8 -11.9 102 137 A W T 3 S+ 0 0 12 -2,-0.3 166,-0.5 -96,-0.3 -1,-0.1 0.699 78.8 63.0 -60.8 -18.2 -2.2 18.3 -14.3 103 138 A S T 3 S+ 0 0 18 164,-0.1 -1,-0.3 -3,-0.1 163,-0.1 0.389 97.1 72.5 -87.7 2.9 1.3 17.2 -13.1 104 139 A G < + 0 0 0 -3,-1.9 3,-0.1 161,-0.1 -23,-0.1 -0.051 38.3 100.6 -98.4-161.1 0.7 13.6 -14.5 105 140 A G + 0 0 2 1,-0.1 2,-2.1 161,-0.1 164,-0.2 0.743 33.0 162.0 88.5 30.0 0.6 11.9 -17.9 106 141 A W > + 0 0 50 1,-0.2 3,-1.0 14,-0.1 -1,-0.1 -0.422 13.5 166.5 -82.8 65.8 4.1 10.4 -18.0 107 142 A H T 3 + 0 0 7 -2,-2.1 42,-1.2 1,-0.2 43,-1.1 0.449 53.9 65.6 -65.4 -16.4 3.1 8.1 -20.8 108 143 A H T 3 S+ 0 0 8 7,-0.2 -1,-0.2 41,-0.2 13,-0.1 0.672 71.8 110.7 -84.7 -22.7 6.4 6.7 -22.1 109 144 A A < - 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