==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=18-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 10-DEC-03 1UTT . COMPND 2 MOLECULE: MACROPHAGE METALLOELASTASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR R.MORALES,S.PERRIER,J.M.FLORENT,J.BELTRA,S.DUFOUR, . 159 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 8319.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 85 53.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 17 10.7 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 4 2.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 12 7.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 12 7.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 34 21.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 106 A G 0 0 96 0, 0.0 120,-0.0 0, 0.0 121,-0.0 0.000 360.0 360.0 360.0 -64.4 99.5 36.3 75.8 2 107 A P + 0 0 78 0, 0.0 2,-0.3 0, 0.0 81,-0.1 -0.276 360.0 178.5 -58.2 142.8 98.7 36.3 79.6 3 108 A V - 0 0 45 78,-0.1 2,-0.2 79,-0.1 117,-0.1 -0.997 32.0-107.1-150.8 147.4 98.9 39.8 81.2 4 109 A W - 0 0 23 115,-0.4 5,-0.0 -2,-0.3 115,-0.0 -0.512 20.0-149.7 -74.1 142.3 98.4 41.3 84.6 5 110 A R S S+ 0 0 229 -2,-0.2 2,-0.3 2,-0.0 -1,-0.1 -0.075 72.6 55.6-103.8 34.1 95.2 43.4 84.9 6 111 A K - 0 0 90 1,-0.1 -2,-0.1 0, 0.0 3,-0.0 -0.976 66.7-138.7-156.5 162.2 96.6 45.9 87.5 7 112 A H S S+ 0 0 99 -2,-0.3 36,-3.0 1,-0.1 2,-0.9 0.748 86.8 74.9 -96.7 -31.1 99.5 48.3 88.0 8 113 A Y E +a 43 0A 164 34,-0.2 2,-0.4 36,-0.1 36,-0.2 -0.762 63.9 174.4 -87.5 107.2 100.3 47.5 91.7 9 114 A I E -a 44 0A 1 34,-3.0 36,-1.7 -2,-0.9 2,-0.3 -0.949 13.7-155.8-118.2 133.0 102.0 44.2 91.7 10 115 A T E -a 45 0A 33 -2,-0.4 44,-2.5 34,-0.2 43,-0.6 -0.763 6.7-169.1-107.1 153.2 103.6 42.6 94.8 11 116 A Y E -ab 46 54A 5 34,-2.2 36,-2.4 -2,-0.3 2,-0.4 -0.957 3.3-162.4-136.3 154.4 106.4 40.1 95.2 12 117 A R E - b 0 55A 82 42,-2.1 44,-2.8 -2,-0.3 2,-1.0 -1.000 21.6-129.4-139.6 136.1 107.6 38.1 98.1 13 118 A I E - b 0 56A 13 34,-0.4 44,-0.2 -2,-0.4 3,-0.1 -0.778 20.9-167.9 -89.2 105.7 110.9 36.3 98.5 14 119 A N - 0 0 90 42,-2.4 2,-0.3 -2,-1.0 43,-0.2 0.912 66.1 -14.0 -58.0 -51.5 109.9 32.8 99.6 15 120 A N - 0 0 53 41,-0.7 2,-0.4 44,-0.0 -1,-0.2 -0.961 69.7-115.8-150.3 164.1 113.4 31.7 100.7 16 121 A Y - 0 0 49 -2,-0.3 6,-0.1 -3,-0.1 41,-0.0 -0.847 19.8-122.2-112.1 143.2 117.0 32.9 100.3 17 122 A T > - 0 0 3 -2,-0.4 3,-0.8 1,-0.1 8,-0.1 -0.548 16.5-139.2 -75.7 143.0 120.0 31.3 98.5 18 123 A P T 3 S+ 0 0 109 0, 0.0 -1,-0.1 0, 0.0 4,-0.1 0.568 92.3 82.8 -79.0 -7.5 123.0 30.8 100.9 19 124 A D T 3 S+ 0 0 46 77,-0.1 2,-0.3 75,-0.1 78,-0.0 0.781 99.8 27.2 -64.7 -30.8 125.2 31.9 98.0 20 125 A M S < S- 0 0 22 -3,-0.8 2,-0.1 79,-0.1 79,-0.1 -0.825 93.2 -92.0-128.7 167.5 124.6 35.6 98.9 21 126 A N >> - 0 0 99 -2,-0.3 4,-1.8 1,-0.1 3,-1.0 -0.492 42.1-111.7 -77.0 152.2 123.7 37.6 101.9 22 127 A R H 3> S+ 0 0 155 1,-0.3 4,-2.5 2,-0.2 3,-0.2 0.900 117.8 50.5 -50.7 -47.2 120.0 38.2 102.4 23 128 A E H 3> S+ 0 0 116 1,-0.2 4,-2.1 2,-0.2 -1,-0.3 0.760 105.3 57.6 -66.0 -24.6 120.3 41.9 101.7 24 129 A D H <> S+ 0 0 49 -3,-1.0 4,-2.5 2,-0.2 -1,-0.2 0.903 109.0 45.6 -70.5 -39.9 122.2 41.2 98.5 25 130 A V H X S+ 0 0 0 -4,-1.8 4,-2.6 -3,-0.2 5,-0.3 0.943 112.1 50.5 -66.1 -49.9 119.3 39.1 97.3 26 131 A D H X S+ 0 0 41 -4,-2.5 4,-2.3 1,-0.2 -2,-0.2 0.918 114.1 45.6 -54.9 -45.9 116.7 41.7 98.3 27 132 A Y H X S+ 0 0 145 -4,-2.1 4,-2.8 2,-0.2 5,-0.2 0.947 111.5 49.6 -64.7 -51.0 118.6 44.4 96.4 28 133 A A H X S+ 0 0 10 -4,-2.5 4,-2.0 1,-0.2 -1,-0.2 0.914 114.5 46.1 -55.0 -45.4 119.3 42.4 93.2 29 134 A I H X S+ 0 0 1 -4,-2.6 4,-2.1 2,-0.2 -1,-0.2 0.919 112.0 50.6 -65.5 -42.8 115.6 41.5 93.0 30 135 A R H X S+ 0 0 166 -4,-2.3 4,-2.1 -5,-0.3 -2,-0.2 0.911 110.9 48.9 -62.4 -41.6 114.4 45.0 93.7 31 136 A K H X S+ 0 0 38 -4,-2.8 4,-1.4 1,-0.2 -1,-0.2 0.884 108.0 55.4 -64.9 -37.1 116.7 46.4 91.0 32 137 A A H X S+ 0 0 0 -4,-2.0 4,-0.8 -5,-0.2 3,-0.2 0.913 109.4 45.6 -62.7 -43.3 115.5 43.8 88.5 33 138 A F H >X S+ 0 0 4 -4,-2.1 4,-2.3 1,-0.2 3,-0.9 0.907 107.7 58.4 -65.1 -42.1 111.9 44.9 89.1 34 139 A Q H 3X S+ 0 0 78 -4,-2.1 4,-1.9 1,-0.3 -1,-0.2 0.804 94.9 65.1 -57.6 -32.5 112.9 48.5 88.8 35 140 A V H 3< S+ 0 0 20 -4,-1.4 4,-0.3 -3,-0.2 -1,-0.3 0.909 111.0 36.7 -57.8 -40.5 114.3 47.9 85.3 36 141 A W H X< S+ 0 0 0 -3,-0.9 3,-1.3 -4,-0.8 6,-0.2 0.881 113.5 53.6 -81.4 -40.6 110.7 47.1 84.2 37 142 A S H >< S+ 0 0 35 -4,-2.3 3,-1.0 1,-0.3 -2,-0.2 0.764 98.4 69.3 -66.3 -21.9 108.8 49.7 86.2 38 143 A N T 3< S+ 0 0 108 -4,-1.9 -1,-0.3 -5,-0.2 -2,-0.2 0.726 107.7 35.0 -67.1 -22.4 111.1 52.3 84.7 39 144 A V T < S+ 0 0 26 -3,-1.3 -1,-0.2 -4,-0.3 -2,-0.2 0.130 121.0 41.9-119.9 21.1 109.5 51.8 81.3 40 145 A T S < S- 0 0 7 -3,-1.0 119,-0.2 2,-0.2 118,-0.1 -0.895 85.9-104.0-151.8 177.0 105.9 51.2 82.3 41 146 A P S S+ 0 0 36 0, 0.0 -4,-0.1 0, 0.0 118,-0.1 0.363 79.5 123.9 -89.2 4.0 103.2 52.4 84.7 42 147 A L - 0 0 4 -6,-0.2 2,-0.4 -34,-0.1 -2,-0.2 -0.356 45.1-161.8 -68.5 145.2 103.8 49.3 86.8 43 148 A K E -a 8 0A 112 -36,-3.0 -34,-3.0 -2,-0.1 2,-0.4 -0.998 3.4-158.7-130.5 129.7 104.7 49.6 90.5 44 149 A F E -a 9 0A 34 -2,-0.4 2,-0.4 -36,-0.2 -34,-0.2 -0.901 8.6-176.7-114.0 137.7 106.3 46.7 92.5 45 150 A S E -a 10 0A 62 -36,-1.7 -34,-2.2 -2,-0.4 2,-0.4 -0.995 21.6-133.0-134.1 137.4 106.3 46.3 96.2 46 151 A K E -a 11 0A 63 -2,-0.4 2,-0.3 -36,-0.2 -34,-0.2 -0.747 25.8-171.2 -89.5 130.9 107.9 43.7 98.4 47 152 A I - 0 0 38 -36,-2.4 -34,-0.4 -2,-0.4 3,-0.1 -0.896 20.9-166.7-121.1 153.7 105.7 42.1 101.1 48 153 A N S S+ 0 0 104 -2,-0.3 2,-0.3 1,-0.2 -1,-0.1 0.465 77.0 39.8-115.5 -7.9 106.6 39.8 103.9 49 154 A T S S+ 0 0 118 2,-0.1 -1,-0.2 0, 0.0 2,-0.1 -0.987 98.2 26.6-140.7 147.4 103.2 38.6 105.0 50 155 A G S S- 0 0 53 -2,-0.3 2,-0.6 -3,-0.1 -3,-0.1 -0.291 99.9 -42.3 93.5 177.5 100.2 37.7 102.9 51 156 A M - 0 0 133 -2,-0.1 2,-0.2 4,-0.0 -41,-0.1 -0.750 56.2-157.2 -88.8 119.2 99.8 36.4 99.3 52 157 A A - 0 0 11 -2,-0.6 3,-0.2 1,-0.1 -41,-0.2 -0.590 20.0-131.8 -91.3 156.0 102.1 38.1 96.9 53 158 A D S S+ 0 0 19 -43,-0.6 2,-0.6 1,-0.3 -42,-0.2 0.932 99.3 36.5 -70.2 -45.9 101.5 38.2 93.1 54 159 A I E S-b 11 0A 0 -44,-2.5 -42,-2.1 34,-0.1 2,-0.5 -0.927 74.2-163.3-114.8 112.8 105.0 37.1 92.3 55 160 A L E -b 12 0A 43 -2,-0.6 35,-2.3 -44,-0.2 2,-0.5 -0.830 8.5-150.6 -96.8 128.2 106.7 34.6 94.6 56 161 A V E -bc 13 90A 2 -44,-2.8 -42,-2.4 -2,-0.5 -41,-0.7 -0.865 20.8-180.0 -99.7 125.1 110.5 34.3 94.3 57 162 A V E - c 0 91A 22 33,-2.8 35,-3.3 -2,-0.5 2,-0.5 -0.975 22.7-153.7-131.3 140.5 111.9 30.9 95.1 58 163 A F E + c 0 92A 6 -2,-0.4 2,-0.3 33,-0.2 35,-0.2 -0.956 37.4 142.1-110.2 123.5 115.4 29.4 95.2 59 164 A A E - c 0 93A 19 33,-2.4 35,-2.0 -2,-0.5 36,-0.4 -0.992 36.7-136.2-158.9 155.9 115.4 25.6 94.6 60 165 A R - 0 0 137 -2,-0.3 33,-0.0 33,-0.3 10,-0.0 -0.746 62.9 -22.7-113.9 162.4 117.4 22.8 92.9 61 166 A G S S+ 0 0 23 -2,-0.3 8,-2.0 7,-0.1 2,-0.6 0.000 124.2 10.9 41.2-135.2 116.3 19.8 90.9 62 167 A A S S+ 0 0 92 6,-0.3 -2,-0.2 1,-0.1 6,-0.1 -0.626 70.8 165.3 -74.4 118.4 112.7 18.7 91.5 63 168 A H - 0 0 43 -2,-0.6 -1,-0.1 -4,-0.1 -2,-0.1 0.083 61.6 -74.1-127.6 25.8 111.1 21.4 93.5 64 169 A G S S+ 0 0 72 0, 0.0 -2,-0.1 0, 0.0 4,-0.0 0.435 112.5 77.2 105.4 -4.7 107.3 21.0 93.4 65 170 A D S S- 0 0 24 2,-0.0 -3,-0.0 0, 0.0 3,-0.0 0.280 97.0-112.8-122.1 10.2 106.1 22.0 90.0 66 171 A F S S+ 0 0 197 1,-0.1 2,-0.3 0, 0.0 -4,-0.1 0.627 93.8 97.9 70.3 14.9 107.1 19.0 87.9 67 172 A H - 0 0 122 -6,-0.1 -1,-0.1 0, 0.0 -4,-0.0 -0.720 63.6-162.5-132.3 79.3 109.7 21.0 85.9 68 173 A A - 0 0 59 -2,-0.3 -6,-0.3 1,-0.1 -7,-0.1 -0.285 16.1-118.5 -67.6 145.4 112.9 20.1 87.6 69 174 A F - 0 0 13 -8,-2.0 -1,-0.1 1,-0.1 3,-0.1 -0.249 20.4-126.0 -74.3 173.5 116.1 22.2 87.2 70 175 A D - 0 0 87 1,-0.4 -1,-0.1 5,-0.4 2,-0.1 0.119 42.4-103.2-113.7 20.6 119.2 20.6 85.7 71 176 A G S S- 0 0 19 4,-0.1 -1,-0.4 3,-0.0 24,-0.1 -0.315 77.5 -5.2 87.2-176.5 122.0 21.2 88.1 72 177 A K S S- 0 0 141 23,-0.1 24,-0.2 -3,-0.1 3,-0.1 -0.256 118.1 -1.1 -57.8 127.6 124.9 23.7 87.8 73 178 A G S S+ 0 0 28 1,-0.1 2,-0.5 20,-0.1 -3,-0.2 -0.218 98.9 65.4 85.6-179.0 124.8 25.6 84.5 74 179 A G S S+ 0 0 69 -2,-0.0 2,-0.4 2,-0.0 -1,-0.1 -0.529 103.7 31.8 70.5-118.5 122.4 25.3 81.6 75 180 A I - 0 0 92 -2,-0.5 -5,-0.4 1,-0.2 3,-0.1 -0.625 66.7-177.1 -74.0 127.5 118.9 26.4 82.7 76 181 A L - 0 0 31 -2,-0.4 17,-1.9 1,-0.4 2,-0.3 0.704 58.7 -32.2 -99.2 -25.2 119.4 29.1 85.4 77 182 A A E -D 92 0A 10 15,-0.2 -1,-0.4 -19,-0.0 2,-0.3 -0.962 51.5-149.5-177.4 175.3 115.8 29.7 86.3 78 183 A H E -D 91 0A 44 13,-2.2 13,-3.1 -2,-0.3 2,-0.3 -0.966 8.3-163.9-159.4 159.3 112.2 29.8 85.0 79 184 A A E -D 90 0A 20 -2,-0.3 2,-0.2 11,-0.2 11,-0.2 -0.997 20.5-117.3-151.8 148.4 109.0 31.7 85.7 80 185 A F - 0 0 62 9,-2.1 8,-0.4 6,-0.4 3,-0.1 -0.605 35.2-112.3 -87.1 146.4 105.3 31.4 85.0 81 186 A G - 0 0 33 -2,-0.2 7,-1.4 1,-0.2 8,-0.2 -0.153 60.3 -51.4 -67.8 170.9 103.4 34.1 83.0 82 187 A P S S+ 0 0 15 0, 0.0 2,-0.3 0, 0.0 -1,-0.2 -0.027 87.7 99.5 -44.4 138.8 100.8 36.4 84.6 83 188 A G - 0 0 31 4,-0.3 2,-0.1 35,-0.1 -3,-0.0 -0.884 67.2 -72.8 159.0 171.1 98.1 34.7 86.6 84 189 A S S > S+ 0 0 113 -2,-0.3 3,-2.4 2,-0.1 2,-0.3 -0.261 97.9 10.0 -82.5 175.2 96.8 33.7 90.0 85 190 A G T 3 S+ 0 0 52 1,-0.3 4,-0.1 -2,-0.1 -2,-0.1 -0.394 144.0 3.4 59.2-115.3 98.3 30.9 92.1 86 191 A I T > S+ 0 0 94 -2,-0.3 3,-2.1 2,-0.1 -6,-0.4 0.716 103.4 119.2 -75.2 -21.6 101.5 29.9 90.5 87 192 A G T < S+ 0 0 11 -3,-2.4 -4,-0.3 1,-0.3 -32,-0.2 -0.126 81.0 10.6 -48.5 135.1 101.2 32.6 87.8 88 193 A G T 3 S+ 0 0 0 -7,-1.4 -1,-0.3 -8,-0.4 30,-0.1 0.137 90.6 141.7 82.6 -21.8 104.1 35.1 87.8 89 194 A D < - 0 0 17 -3,-2.1 -9,-2.1 -8,-0.2 2,-0.5 -0.242 39.2-149.7 -58.5 139.6 106.2 33.0 90.2 90 195 A A E -cD 56 79A 2 -35,-2.3 -33,-2.8 -11,-0.2 2,-0.5 -0.954 8.8-165.2-117.0 125.8 109.9 33.0 89.5 91 196 A H E -cD 57 78A 17 -13,-3.1 -13,-2.2 -2,-0.5 2,-0.5 -0.934 3.5-158.4-113.6 130.6 112.1 30.0 90.4 92 197 A F E -cD 58 77A 1 -35,-3.3 -33,-2.4 -2,-0.5 2,-0.5 -0.933 25.8-116.9-113.2 124.8 115.9 30.2 90.6 93 198 A D E > -c 59 0A 0 -17,-1.9 3,-2.0 -2,-0.5 -33,-0.3 -0.415 19.7-158.3 -61.0 108.0 118.0 27.1 90.2 94 199 A E T 3 S+ 0 0 13 -35,-2.0 -34,-0.2 -2,-0.5 -1,-0.2 0.684 86.0 74.5 -64.0 -18.4 119.9 26.8 93.6 95 200 A D T 3 S+ 0 0 48 -36,-0.4 -1,-0.3 -24,-0.1 2,-0.2 0.633 83.5 83.3 -71.0 -10.0 122.5 24.6 91.9 96 201 A E S < S- 0 0 5 -3,-2.0 2,-0.9 -20,-0.2 -77,-0.1 -0.530 89.8-120.3 -84.6 161.1 123.8 27.8 90.3 97 202 A F - 0 0 95 -2,-0.2 8,-2.8 -78,-0.0 2,-0.2 -0.867 33.0-151.2-104.4 98.6 126.2 29.9 92.3 98 203 A W E +e 105 0B 0 -2,-0.9 2,-0.3 6,-0.2 8,-0.2 -0.471 22.7 168.7 -73.7 139.2 124.4 33.2 92.5 99 204 A T E -e 106 0B 4 6,-1.7 8,-2.1 2,-0.2 9,-0.4 -0.889 47.8-129.8-143.8 173.3 126.4 36.4 92.8 100 205 A T S S+ 0 0 85 -2,-0.3 2,-0.2 6,-0.2 6,-0.1 0.281 94.6 47.2-103.4 3.1 126.3 40.2 92.7 101 206 A H S S- 0 0 92 2,-0.2 -2,-0.2 4,-0.1 6,-0.1 -0.499 106.1 -72.6-128.9-162.7 129.3 40.1 90.3 102 207 A S S S+ 0 0 81 -2,-0.2 4,-0.1 3,-0.1 35,-0.1 0.558 99.0 89.1 -76.0 -10.9 130.7 38.6 87.1 103 208 A G S S- 0 0 24 2,-0.1 -2,-0.2 -5,-0.0 -4,-0.2 -0.402 93.8 -6.3 -84.2 167.3 131.4 35.2 88.8 104 209 A G S S- 0 0 43 -2,-0.1 2,-0.5 -6,-0.1 -6,-0.2 -0.217 122.0 -34.5 49.6-135.4 129.0 32.3 89.0 105 210 A T E -e 98 0B 14 -8,-2.8 -6,-1.7 -29,-0.0 2,-0.4 -0.982 64.8-121.8-122.4 122.4 125.6 33.5 87.7 106 211 A N E > -e 99 0B 6 -2,-0.5 4,-1.9 -8,-0.2 5,-0.2 -0.460 16.6-157.6 -66.4 118.2 124.5 37.1 88.2 107 212 A L H > S+ 0 0 0 -8,-2.1 4,-3.1 -2,-0.4 5,-0.2 0.940 88.4 52.3 -62.0 -49.7 121.2 37.1 90.1 108 213 A F H > S+ 0 0 13 -9,-0.4 4,-2.0 1,-0.2 -1,-0.2 0.926 111.2 45.5 -53.2 -52.1 120.2 40.6 89.0 109 214 A L H > S+ 0 0 12 1,-0.2 4,-1.6 2,-0.2 -1,-0.2 0.921 116.1 46.2 -59.7 -44.8 120.7 40.0 85.3 110 215 A T H X S+ 0 0 7 -4,-1.9 4,-2.6 1,-0.2 -1,-0.2 0.890 110.1 54.2 -66.0 -38.6 118.9 36.6 85.5 111 216 A A H X S+ 0 0 0 -4,-3.1 4,-2.9 1,-0.2 5,-0.3 0.854 103.4 56.2 -64.7 -35.3 116.1 38.1 87.6 112 217 A V H X S+ 0 0 0 -4,-2.0 4,-1.4 -5,-0.2 -1,-0.2 0.945 110.5 45.0 -61.5 -46.0 115.5 40.8 84.9 113 218 A H H X S+ 0 0 28 -4,-1.6 4,-1.3 2,-0.2 -2,-0.2 0.947 115.2 47.0 -61.1 -51.3 115.0 38.1 82.3 114 219 A E H X S+ 0 0 8 -4,-2.6 4,-2.4 1,-0.2 3,-0.4 0.900 109.8 51.8 -60.3 -44.0 112.7 36.0 84.6 115 220 A I H X S+ 0 0 5 -4,-2.9 4,-2.1 1,-0.3 -1,-0.2 0.828 100.9 64.0 -63.9 -29.0 110.6 38.9 85.7 116 221 A G H <>S+ 0 0 0 -4,-1.4 5,-2.6 -5,-0.3 4,-0.3 0.942 107.2 42.4 -58.0 -44.0 110.2 39.7 82.0 117 222 A H H ><5S+ 0 0 33 -4,-1.3 3,-2.0 -3,-0.4 -2,-0.2 0.928 109.0 57.6 -66.0 -46.0 108.4 36.3 81.8 118 223 A S H 3<5S+ 0 0 0 -4,-2.4 -1,-0.2 1,-0.3 -2,-0.2 0.824 107.7 49.7 -53.4 -32.4 106.5 37.0 85.1 119 224 A L T 3<5S- 0 0 0 -4,-2.1 -115,-0.4 -5,-0.2 -1,-0.3 0.520 130.8 -91.5 -86.9 -6.8 105.1 40.1 83.4 120 225 A G T < 5S+ 0 0 14 -3,-2.0 2,-0.4 -4,-0.3 -3,-0.2 0.562 79.1 134.5 111.3 8.6 104.0 38.3 80.2 121 226 A L < - 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0 0 171 -2,-0.1 -2,-0.0 2,-0.0 2,-0.0 -0.900 32.6-122.0-151.5 116.9 125.8 36.9 78.8 137 242 A Y + 0 0 72 -2,-0.3 2,-0.3 -35,-0.1 -35,-0.1 -0.312 34.1 169.9 -62.7 141.2 127.2 38.8 81.7 138 243 A V - 0 0 51 5,-0.0 5,-0.1 -2,-0.0 -29,-0.1 -0.971 43.3 -97.7-148.7 136.9 127.2 42.6 81.5 139 244 A D >> - 0 0 59 -2,-0.3 3,-1.3 1,-0.1 4,-1.1 -0.318 30.7-126.5 -57.9 139.8 128.0 45.0 84.4 140 245 A I T 34 S+ 0 0 69 1,-0.3 3,-0.4 2,-0.2 -1,-0.1 0.849 107.1 63.1 -56.5 -35.3 124.9 46.2 86.1 141 246 A N T 34 S+ 0 0 137 1,-0.2 -1,-0.3 3,-0.0 -2,-0.1 0.776 113.5 32.8 -62.9 -27.5 126.0 49.8 85.6 142 247 A T T <4 S+ 0 0 106 -3,-1.3 -1,-0.2 2,-0.0 -2,-0.2 0.477 91.1 117.8-108.6 -3.0 125.9 49.5 81.8 143 248 A F < + 0 0 39 -4,-1.1 2,-0.3 -3,-0.4 -3,-0.0 -0.360 36.6 166.5 -64.5 141.8 123.0 47.0 81.5 144 249 A R - 0 0 211 -2,-0.1 -2,-0.0 0, 0.0 -3,-0.0 -0.980 38.8-105.7-157.9 144.4 120.0 48.3 79.6 145 250 A L - 0 0 20 -2,-0.3 2,-0.2 -110,-0.1 -16,-0.1 -0.309 41.1-120.9 -63.1 153.2 116.8 46.9 78.0 146 251 A S > - 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