==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=5-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER GROWTH FACTOR 29-JUL-97 2VPF . COMPND 2 MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR Y.A.MULLER,A.M.DE VOS . 762 8 31 24 7 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 42294.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 479 62.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 32 4.2 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 264 34.6 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 7 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 65 8.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 45 5.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 64 8.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 8 0 0 2 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 1 6 1 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 13 A E 0 0 147 0, 0.0 162,-0.3 0, 0.0 2,-0.1 0.000 360.0 360.0 360.0 62.9 23.2 3.5 -1.9 2 14 A V - 0 0 45 160,-0.1 2,-0.5 1,-0.1 162,-0.2 -0.332 360.0-121.8 -66.5 137.0 21.2 6.7 -1.8 3 15 A V B -a 164 0A 17 160,-2.6 162,-2.7 -2,-0.1 2,-0.1 -0.723 34.7-119.5 -79.9 125.3 18.1 6.9 -4.1 4 16 A K > - 0 0 129 -2,-0.5 4,-2.3 160,-0.2 3,-0.4 -0.408 16.9-114.9 -70.7 144.1 18.6 9.8 -6.4 5 17 A F H > S+ 0 0 24 1,-0.2 4,-2.4 2,-0.2 5,-0.2 0.800 112.9 46.2 -45.1 -55.0 16.1 12.7 -6.5 6 18 A M H > S+ 0 0 114 1,-0.2 4,-2.5 2,-0.2 -1,-0.2 0.867 112.5 52.5 -66.9 -32.1 14.7 12.2 -10.0 7 19 A D H > S+ 0 0 86 -3,-0.4 4,-2.1 2,-0.2 -2,-0.2 0.919 112.1 44.1 -63.7 -45.8 14.3 8.5 -9.4 8 20 A V H X S+ 0 0 0 -4,-2.3 4,-1.4 2,-0.2 -2,-0.2 0.895 113.6 51.8 -64.8 -43.4 12.3 8.9 -6.2 9 21 A Y H X S+ 0 0 48 -4,-2.4 4,-1.6 -5,-0.2 3,-0.4 0.936 111.2 46.2 -58.3 -47.5 10.2 11.6 -7.8 10 22 A Q H < S+ 0 0 141 -4,-2.5 -1,-0.2 1,-0.2 -2,-0.2 0.871 113.8 49.5 -65.2 -36.3 9.3 9.5 -10.8 11 23 A R H < S+ 0 0 82 -4,-2.1 -1,-0.2 -5,-0.2 -2,-0.2 0.713 114.1 42.8 -72.4 -29.6 8.5 6.4 -8.5 12 24 A S H < S+ 0 0 0 -4,-1.4 36,-2.0 -3,-0.4 -1,-0.2 0.725 85.3 113.5 -91.5 -19.8 6.2 8.2 -6.1 13 25 A Y B < S-d 48 0B 83 -4,-1.6 36,-0.2 34,-0.2 33,-0.1 -0.250 87.6 -73.1 -61.5 130.6 4.2 10.3 -8.6 14 26 A a S S+ 0 0 9 34,-2.4 33,-0.2 31,-0.1 76,-0.2 0.196 78.7 131.2 -17.0 110.7 0.5 9.5 -8.9 15 27 A H E -E 46 0C 59 31,-2.1 31,-1.5 -3,-0.2 2,-0.3 -0.979 63.8 -74.0-163.9 164.0 0.1 6.1 -10.8 16 28 A P E +E 45 0C 34 0, 0.0 2,-0.3 0, 0.0 29,-0.2 -0.553 55.4 177.1 -67.4 127.2 -1.8 2.8 -10.5 17 29 A I E -E 44 0C 21 27,-2.5 27,-2.0 -2,-0.3 2,-0.2 -0.984 39.3 -94.7-135.0 143.6 -0.1 0.6 -7.8 18 30 A E E -E 43 0C 68 -2,-0.3 2,-0.4 25,-0.2 25,-0.2 -0.382 49.8-177.7 -58.9 124.2 -0.9 -2.8 -6.4 19 31 A T E -E 42 0C 49 23,-2.9 23,-3.1 -2,-0.2 2,-0.6 -0.973 26.3-130.0-130.0 131.5 -3.0 -2.2 -3.2 20 32 A L E -E 41 0C 38 -2,-0.4 2,-0.5 21,-0.2 125,-0.2 -0.745 31.5-168.8 -92.3 117.3 -4.4 -4.8 -0.7 21 33 A V E -E 40 0C 8 19,-2.9 19,-1.8 -2,-0.6 2,-0.1 -0.928 22.6-119.8-116.8 132.6 -8.1 -4.1 -0.2 22 34 A D E > -E 39 0C 59 -2,-0.5 4,-1.0 17,-0.2 17,-0.3 -0.350 17.2-147.1 -70.5 133.8 -10.4 -5.6 2.4 23 35 A I H >> S+ 0 0 0 15,-2.5 4,-1.3 2,-0.2 3,-0.6 0.915 96.0 52.9 -71.4 -45.4 -13.3 -7.5 0.9 24 36 A F H 34 S+ 0 0 90 14,-0.4 3,-0.3 1,-0.3 6,-0.2 0.893 104.7 58.6 -59.4 -36.5 -16.0 -6.7 3.5 25 37 A Q H 34 S+ 0 0 121 1,-0.2 -1,-0.3 2,-0.2 -2,-0.2 0.889 111.5 41.0 -54.4 -41.0 -15.1 -3.0 3.0 26 38 A E H << S+ 0 0 65 -4,-1.0 -1,-0.2 -3,-0.6 -2,-0.2 0.644 126.5 35.1 -81.3 -19.3 -16.1 -3.5 -0.7 27 39 A Y >< + 0 0 62 -4,-1.3 3,-2.1 -3,-0.3 -1,-0.2 -0.467 67.7 162.7-132.3 61.3 -19.1 -5.7 0.1 28 40 A P T 3 S+ 0 0 67 0, 0.0 3,-0.2 0, 0.0 -1,-0.1 0.744 71.2 62.7 -62.7 -13.7 -20.6 -4.3 3.4 29 41 A D T 3 S+ 0 0 141 1,-0.2 2,-0.6 2,-0.1 3,-0.3 0.570 81.7 83.2 -92.4 -0.4 -24.0 -6.0 3.0 30 42 A E X + 0 0 40 -3,-2.1 3,-1.5 1,-0.2 -1,-0.2 -0.190 51.8 140.8 -96.1 50.3 -22.3 -9.4 3.2 31 43 A I T 3 + 0 0 118 -2,-0.6 -1,-0.2 1,-0.3 -2,-0.1 0.775 60.9 61.8 -61.9 -27.7 -22.3 -9.3 7.1 32 44 A E T 3 S+ 0 0 86 -3,-0.3 2,-0.3 40,-0.1 -1,-0.3 0.468 98.7 70.5 -81.8 -0.9 -23.2 -13.0 7.5 33 45 A Y < - 0 0 54 -3,-1.5 2,-0.4 39,-0.1 39,-0.2 -0.879 61.0-155.7-120.6 148.7 -20.0 -14.1 5.8 34 46 A I E -F 71 0D 88 37,-2.4 37,-2.8 -2,-0.3 2,-0.3 -0.906 28.5-139.1-113.9 137.1 -16.3 -14.1 6.6 35 47 A F E -F 70 0D 16 -2,-0.4 35,-0.2 35,-0.2 -11,-0.1 -0.847 6.0-126.1-102.0 152.3 -14.1 -14.2 3.4 36 48 A K E S+F 69 0D 48 33,-2.2 33,-2.9 -2,-0.3 2,-0.1 -0.985 105.4 25.9-141.3 117.4 -10.9 -16.1 2.7 37 49 A P S S- 0 0 0 0, 0.0 -1,-0.2 0, 0.0 70,-0.1 0.738 89.0-155.0 -70.6 164.5 -8.7 -14.6 1.8 38 50 A S S S+ 0 0 31 -2,-0.1 -15,-2.5 69,-0.1 -14,-0.4 0.524 75.0 34.8 -84.2 -12.0 -10.1 -11.5 3.6 39 51 A b E S-E 22 0C 7 -17,-0.3 -17,-0.2 -16,-0.1 71,-0.1 -0.916 70.0-148.5-135.4 165.4 -8.4 -9.0 1.3 40 52 A V E -E 21 0C 0 -19,-1.8 -19,-2.9 -2,-0.3 2,-0.7 -0.985 22.3-113.6-138.7 145.4 -7.4 -8.9 -2.4 41 53 A P E +E 20 0C 2 0, 0.0 2,-0.4 0, 0.0 -21,-0.2 -0.722 44.4 171.6 -76.7 111.1 -4.6 -7.3 -4.5 42 54 A L E -E 19 0C 1 -23,-3.1 -23,-2.9 -2,-0.7 2,-0.4 -0.979 39.7-116.5-124.1 144.9 -6.0 -4.6 -6.8 43 55 A M E +E 18 0C 65 -2,-0.4 44,-2.1 -25,-0.2 2,-0.3 -0.615 50.0 167.0 -74.0 116.1 -4.4 -2.0 -9.0 44 56 A R E -E 17 0C 37 -27,-2.0 -27,-2.5 -2,-0.4 -29,-0.1 -0.997 43.1 -94.8-135.9 145.2 -5.5 1.3 -7.4 45 57 A c E +E 16 0C 26 -2,-0.3 2,-0.3 -29,-0.2 -31,-0.1 -0.326 59.7 149.9 -59.8 139.8 -4.4 4.9 -7.8 46 58 A G E +E 15 0C 19 -31,-1.5 -31,-2.1 -33,-0.1 2,-0.1 -0.978 18.5 63.7-162.4 167.8 -1.7 5.9 -5.2 47 59 A G S S- 0 0 27 -2,-0.3 9,-0.2 -33,-0.2 2,-0.2 -0.497 75.5 -58.0 101.0-172.6 1.3 8.1 -4.7 48 60 A d B -d 13 0B 16 -36,-2.0 -34,-2.4 -2,-0.1 2,-0.2 -0.669 28.5-138.7-121.5 165.4 1.5 11.9 -4.6 49 61 A e - 0 0 14 5,-0.3 87,-0.3 -2,-0.2 7,-0.1 -0.624 38.8-100.3-108.6 170.6 0.8 15.0 -6.6 50 62 A N S S+ 0 0 76 -2,-0.2 2,-0.3 85,-0.1 -1,-0.0 0.628 99.8 13.3 -77.2 -8.9 3.0 18.2 -6.9 51 63 A D S > S- 0 0 94 3,-0.0 3,-1.4 83,-0.0 -2,-0.1 -0.966 79.3-107.3-152.3 164.5 1.0 20.3 -4.4 52 64 A E T 3 S+ 0 0 165 -2,-0.3 43,-0.1 1,-0.3 -2,-0.0 0.454 110.6 71.1 -72.9 -1.9 -1.7 19.8 -1.7 53 65 A G T 3 S+ 0 0 41 41,-0.1 42,-2.5 2,-0.0 2,-0.3 0.526 94.4 70.8 -87.0 -6.3 -4.4 21.5 -3.9 54 66 A L E < - G 0 94D 45 -3,-1.4 2,-0.3 40,-0.3 -5,-0.3 -0.859 63.1-164.3-111.0 147.7 -4.2 18.3 -6.1 55 67 A E E - G 0 93D 90 38,-2.7 38,-2.5 -2,-0.3 2,-0.6 -0.945 26.7-115.4-130.7 152.4 -5.4 14.7 -5.6 56 68 A a E + G 0 92D 30 -2,-0.3 36,-0.2 -9,-0.2 -41,-0.1 -0.806 45.5 171.3 -89.9 109.4 -4.5 11.5 -7.5 57 69 A V E - G 0 91D 36 34,-2.5 34,-2.4 -2,-0.6 2,-0.2 -0.890 34.6-100.9-131.3 150.6 -7.7 10.2 -9.1 58 70 A P E + G 0 90D 41 0, 0.0 32,-0.3 0, 0.0 3,-0.1 -0.512 27.9 175.1 -70.4 140.3 -8.6 7.4 -11.6 59 71 A T E S+ 0 0 59 30,-2.7 2,-0.3 1,-0.4 31,-0.2 0.220 75.4 35.6-121.7 0.1 -9.3 8.3 -15.3 60 72 A E E S- G 0 89D 89 29,-1.0 28,-2.6 2,-0.0 29,-1.3 -0.903 70.3-179.8-156.5 127.1 -9.8 4.8 -16.6 61 73 A E E + G 0 87D 105 -2,-0.3 2,-0.3 26,-0.3 26,-0.2 -0.893 6.3 168.0-133.0 161.9 -11.3 1.8 -14.7 62 74 A S E - 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