==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=7-AUG-2011 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER CHAPERONE 08-MAY-09 2WI6 . COMPND 2 MOLECULE: HEAT SHOCK PROTEIN, HSP90-ALPHA; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR P.A.BROUGH,X.BARRIL,J.BORGOGNONI,P.CHENE,N.G.M.DAVIES,B.DAVI . 208 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 10530.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 159 76.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 4 1.9 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 42 20.2 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 22 10.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 31 14.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 55 26.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 3 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 0 0 1 1 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 0 1 1 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 16 A E 0 0 218 0, 0.0 158,-0.6 0, 0.0 2,-0.5 0.000 360.0 360.0 360.0 -73.3 37.0 27.8 38.8 2 17 A V E -A 158 0A 63 156,-0.1 2,-0.4 154,-0.0 156,-0.2 -0.938 360.0-161.6-103.8 114.7 38.6 27.0 35.4 3 18 A E E -A 157 0A 91 154,-2.9 154,-2.0 -2,-0.5 2,-0.5 -0.830 6.1-151.7 -93.2 136.4 41.3 24.3 35.4 4 19 A T E -A 156 0A 103 -2,-0.4 2,-0.3 152,-0.2 152,-0.2 -0.931 16.4-177.2-108.6 126.7 43.7 24.1 32.4 5 20 A F E -A 155 0A 56 150,-3.6 150,-2.2 -2,-0.5 2,-0.5 -0.815 23.1-121.6-122.0 155.5 45.2 20.7 31.4 6 21 A A E -A 154 0A 81 -2,-0.3 148,-0.3 148,-0.2 3,-0.1 -0.839 28.0-118.6 -96.1 130.1 47.7 19.6 28.7 7 22 A F - 0 0 11 146,-3.6 2,-0.2 -2,-0.5 87,-0.1 -0.378 39.4-101.2 -52.9 136.5 46.8 17.1 26.2 8 23 A Q >> - 0 0 44 85,-2.5 4,-2.2 1,-0.1 3,-0.9 -0.493 42.7-106.4 -55.7 134.7 48.9 14.1 26.5 9 24 A A H 3> S+ 0 0 75 1,-0.3 4,-1.3 2,-0.2 5,-0.2 0.782 116.4 50.2 -43.1 -44.3 51.6 14.5 23.6 10 25 A E H 3> S+ 0 0 66 1,-0.2 4,-3.1 2,-0.2 3,-0.4 0.929 110.6 47.8 -60.1 -47.9 50.1 11.8 21.3 11 26 A I H <> S+ 0 0 1 -3,-0.9 4,-2.8 1,-0.3 5,-0.2 0.902 111.5 52.2 -60.6 -41.6 46.5 13.2 21.5 12 27 A A H X S+ 0 0 28 -4,-2.2 4,-2.2 2,-0.2 -1,-0.3 0.842 110.4 47.2 -64.9 -27.5 47.8 16.6 20.8 13 28 A Q H X S+ 0 0 98 -4,-1.3 4,-2.7 -3,-0.4 -2,-0.2 0.944 111.5 51.3 -84.0 -37.9 49.7 15.3 17.7 14 29 A L H X S+ 0 0 0 -4,-3.1 4,-2.9 1,-0.2 5,-0.2 0.915 110.2 48.7 -56.6 -52.2 46.7 13.5 16.5 15 30 A M H X S+ 0 0 3 -4,-2.8 4,-2.6 2,-0.2 5,-0.3 0.952 110.8 51.4 -52.4 -52.1 44.6 16.6 16.8 16 31 A S H X S+ 0 0 62 -4,-2.2 4,-1.8 -5,-0.2 -2,-0.2 0.904 110.1 48.8 -49.3 -48.7 47.4 18.5 15.0 17 32 A L H X S+ 0 0 51 -4,-2.7 4,-3.4 2,-0.2 -2,-0.2 0.940 112.3 49.2 -57.4 -49.5 47.3 15.9 12.2 18 33 A I H < S+ 0 0 3 -4,-2.9 -2,-0.2 1,-0.3 -1,-0.2 0.842 114.5 43.8 -64.1 -37.0 43.5 16.1 12.0 19 34 A I H < S+ 0 0 64 -4,-2.6 -1,-0.3 -5,-0.2 -2,-0.2 0.789 123.8 35.8 -79.7 -23.9 43.5 19.9 11.8 20 35 A N H < S+ 0 0 118 -4,-1.8 2,-0.2 -5,-0.3 -2,-0.2 0.673 87.3 98.6-105.0 -22.9 46.4 20.0 9.3 21 36 A T S < S- 0 0 55 -4,-3.4 2,-0.4 -5,-0.2 -4,-0.0 -0.505 76.6-124.4 -68.3 130.0 46.0 17.1 7.0 22 37 A F + 0 0 180 -2,-0.2 2,-0.3 2,-0.0 -2,-0.1 -0.671 51.2 152.0 -69.5 126.4 44.3 18.2 3.7 23 38 A Y - 0 0 32 -2,-0.4 3,-0.1 105,-0.1 -2,-0.0 -0.785 31.6-164.4-165.5 111.1 41.3 15.9 3.6 24 39 A S S S+ 0 0 95 -2,-0.3 2,-2.2 1,-0.2 3,-0.2 0.757 72.3 81.4 -79.7 -25.7 38.0 16.7 1.9 25 40 A N > + 0 0 63 1,-0.2 3,-1.2 2,-0.1 -1,-0.2 -0.262 52.3 149.3 -79.5 53.7 35.6 14.1 3.2 26 41 A K T > + 0 0 39 -2,-2.2 3,-1.6 1,-0.3 -1,-0.2 0.635 48.0 83.2 -65.6 -16.5 35.0 16.0 6.5 27 42 A E T >> + 0 0 13 1,-0.3 3,-1.1 -3,-0.2 4,-0.7 0.533 66.4 84.7 -72.5 -9.2 31.4 14.9 7.1 28 43 A I H <> S+ 0 0 1 -3,-1.2 4,-1.8 1,-0.2 -1,-0.3 0.629 71.4 81.3 -66.4 -10.5 32.6 11.6 8.7 29 44 A F H <> S+ 0 0 1 -3,-1.6 4,-1.9 1,-0.2 -1,-0.2 0.888 87.0 54.3 -62.9 -36.0 32.8 13.6 12.0 30 45 A L H <> S+ 0 0 3 -3,-1.1 4,-3.6 1,-0.3 5,-0.4 0.923 105.1 51.1 -68.5 -46.0 29.1 13.3 12.6 31 46 A R H X S+ 0 0 54 -4,-0.7 4,-2.6 1,-0.2 -1,-0.3 0.927 107.9 54.0 -60.0 -38.9 29.0 9.6 12.3 32 47 A E H X S+ 0 0 10 -4,-1.8 4,-2.2 1,-0.2 -2,-0.2 0.940 114.8 40.2 -62.1 -39.6 31.8 9.5 14.9 33 48 A L H X S+ 0 0 4 -4,-1.9 4,-2.2 2,-0.2 -2,-0.2 0.894 114.3 50.6 -75.2 -45.1 29.8 11.6 17.4 34 49 A I H X S+ 0 0 0 -4,-3.6 4,-2.0 1,-0.2 -1,-0.2 0.931 112.5 49.7 -55.7 -41.5 26.5 10.0 16.7 35 50 A S H X S+ 0 0 41 -4,-2.6 4,-2.2 -5,-0.4 -2,-0.2 0.930 106.2 53.4 -70.2 -38.7 28.3 6.7 17.3 36 51 A N H X S+ 0 0 65 -4,-2.2 4,-1.8 -5,-0.2 -1,-0.2 0.919 110.0 52.3 -52.2 -44.3 30.0 7.8 20.6 37 52 A S H X S+ 0 0 4 -4,-2.2 4,-1.8 2,-0.2 5,-0.3 0.934 105.2 51.6 -58.1 -50.8 26.5 8.7 21.7 38 53 A S H >X S+ 0 0 15 -4,-2.0 4,-3.4 1,-0.2 3,-0.5 0.957 109.0 51.1 -56.5 -49.5 24.9 5.3 20.9 39 54 A D H 3X S+ 0 0 90 -4,-2.2 4,-3.0 1,-0.2 -1,-0.2 0.904 110.2 51.3 -48.6 -44.7 27.7 3.5 22.9 40 55 A A H 3X S+ 0 0 18 -4,-1.8 41,-1.8 2,-0.2 4,-0.9 0.749 111.4 45.5 -69.6 -27.8 26.9 5.8 25.8 41 56 A L H < S+ 0 0 181 -4,-2.5 3,-1.5 -5,-0.3 -2,-0.2 0.976 108.3 43.7 -66.0 -56.0 23.3 -1.9 30.4 47 62 A E H >< S+ 0 0 45 -4,-1.4 3,-1.1 1,-0.3 -1,-0.2 0.689 103.2 66.2 -64.0 -21.5 23.5 -0.7 33.9 48 63 A S T 3< S+ 0 0 8 -4,-1.7 3,-0.3 1,-0.2 -1,-0.3 0.260 87.1 70.5 -88.1 16.2 19.8 -0.1 34.3 49 64 A L T < S+ 0 0 152 -3,-1.5 -1,-0.2 1,-0.2 -2,-0.2 0.281 106.7 38.1-103.7 6.5 19.2 -3.8 33.9 50 65 A T S < S+ 0 0 115 -3,-1.1 -1,-0.2 1,-0.2 -2,-0.1 -0.434 136.4 17.4-145.4 61.2 20.7 -4.2 37.3 51 66 A D > - 0 0 60 -3,-0.3 3,-1.8 2,-0.0 4,-0.2 0.419 62.5-166.6 132.7 66.0 19.3 -1.1 39.0 52 67 A P T 3 S+ 0 0 106 0, 0.0 -4,-0.1 0, 0.0 3,-0.1 0.251 79.5 91.0 -64.6 25.8 16.4 0.2 36.9 53 68 A S T > + 0 0 55 1,-0.1 3,-0.7 2,-0.1 -5,-0.1 0.423 63.5 70.8 -98.8 -5.2 17.2 3.0 39.3 54 69 A K G X S+ 0 0 62 -3,-1.8 3,-0.8 1,-0.2 -1,-0.1 0.676 85.5 67.6 -90.6 -14.4 19.7 4.9 37.1 55 70 A L G > S+ 0 0 33 -4,-0.2 3,-0.8 1,-0.2 -1,-0.2 0.210 71.9 97.7 -83.4 14.5 17.0 6.0 34.7 56 71 A D G < S+ 0 0 127 -3,-0.7 -1,-0.2 1,-0.2 -2,-0.1 0.770 82.1 49.5 -73.8 -23.1 15.7 8.2 37.5 57 72 A S G < S- 0 0 39 -3,-0.8 -1,-0.2 -4,-0.1 -2,-0.1 0.316 139.0 -21.7 -95.0 3.5 17.6 11.2 36.0 58 73 A G < - 0 0 42 -3,-0.8 2,-1.2 108,-0.1 -3,-0.1 0.134 50.8-175.1-166.2 -71.4 16.1 10.5 32.6 59 74 A K + 0 0 145 -5,-0.1 2,-0.7 20,-0.1 -3,-0.1 -0.262 59.9 100.8 75.5 -50.3 14.7 7.4 31.0 60 75 A E - 0 0 140 -2,-1.2 2,-1.2 -5,-0.1 -1,-0.1 -0.597 62.5-156.2 -75.7 112.3 14.1 8.7 27.4 61 76 A L + 0 0 36 -2,-0.7 2,-0.2 17,-0.1 -1,-0.1 -0.611 38.2 129.7 -94.1 81.1 17.1 7.2 25.6 62 77 A H - 0 0 37 -2,-1.2 17,-1.6 139,-0.1 2,-0.4 -0.709 50.4-131.9-133.0 176.0 17.7 9.5 22.5 63 78 A I E -Bc 78 203A 0 139,-2.5 141,-2.3 -2,-0.2 2,-0.4 -0.992 21.6-166.5-131.2 120.8 20.1 11.6 20.4 64 79 A N E -Bc 77 204A 20 13,-2.4 13,-2.8 -2,-0.4 2,-0.5 -0.880 9.1-153.1-105.7 144.1 19.2 15.2 19.2 65 80 A L E -Bc 76 205A 0 139,-2.9 141,-2.8 -2,-0.4 11,-0.2 -0.976 14.7-172.8-116.6 123.9 21.0 17.2 16.6 66 81 A I E -B 75 0A 50 9,-3.0 9,-2.4 -2,-0.5 2,-0.3 -0.906 4.8-172.9-130.3 102.1 20.8 20.9 17.1 67 82 A P E -B 74 0A 9 0, 0.0 2,-0.3 0, 0.0 7,-0.2 -0.685 0.8-174.7 -87.0 141.8 22.0 23.4 14.4 68 83 A N E >> -B 73 0A 43 5,-2.5 5,-1.8 -2,-0.3 4,-0.5 -0.882 8.2-168.8-144.8 107.5 22.1 27.1 15.2 69 84 A K T 45S+ 0 0 114 -2,-0.3 3,-0.2 1,-0.3 -1,-0.1 0.812 84.9 54.1 -71.1 -32.0 23.1 29.5 12.4 70 85 A Q T 45S+ 0 0 164 1,-0.2 -1,-0.3 2,-0.1 -2,-0.0 0.823 117.5 34.7 -78.5 -28.2 23.5 32.5 14.4 71 86 A D T 45S- 0 0 96 -3,-0.4 -1,-0.2 2,-0.2 -2,-0.2 0.390 104.1-133.2 -93.5 -2.9 25.9 31.0 16.9 72 87 A R T <5 + 0 0 69 -4,-0.5 103,-2.0 -3,-0.2 2,-0.3 0.869 60.1 133.3 48.0 47.8 27.3 28.9 14.1 73 88 A T E < -BD 68 174A 10 -5,-1.8 -5,-2.5 101,-0.2 2,-0.4 -0.922 46.1-159.1-123.5 151.3 27.2 25.8 16.3 74 89 A L E -BD 67 173A 1 99,-1.7 99,-3.4 -2,-0.3 2,-0.5 -1.000 18.3-162.9-124.8 127.0 26.0 22.2 15.8 75 90 A T E -BD 66 172A 15 -9,-2.4 -9,-3.0 -2,-0.4 2,-0.6 -0.939 12.3-159.6-116.9 127.4 25.3 20.4 19.0 76 91 A I E -BD 65 171A 0 95,-2.4 95,-2.9 -2,-0.5 2,-0.4 -0.970 20.2-171.7-102.9 109.3 25.0 16.6 19.3 77 92 A V E +BD 64 170A 23 -13,-2.8 -13,-2.4 -2,-0.6 2,-0.3 -0.906 7.0 175.7-105.3 129.8 23.0 15.9 22.6 78 93 A D E -BD 63 169A 8 91,-2.3 91,-1.3 -2,-0.4 -15,-0.2 -0.963 33.4-143.4-127.6 153.1 22.6 12.4 24.1 79 94 A T + 0 0 27 -17,-1.6 89,-0.2 -2,-0.3 -20,-0.1 -0.207 62.1 128.8 -97.9 43.8 21.0 11.1 27.3 80 95 A G S S- 0 0 0 89,-0.2 -39,-0.3 -18,-0.1 -40,-0.1 0.201 78.8 -61.2 -82.9-152.4 23.7 8.4 27.6 81 96 A I - 0 0 16 -41,-1.8 59,-0.6 -44,-0.2 87,-0.2 0.730 68.0-156.9 -69.6 -22.3 25.9 7.4 30.6 82 97 A G - 0 0 5 57,-0.2 2,-0.4 85,-0.2 57,-0.2 -0.018 16.3 -92.4 69.1 176.3 27.7 10.8 30.8 83 98 A M - 0 0 27 85,-0.4 56,-0.3 62,-0.1 62,-0.3 -0.990 19.5-132.8-130.2 144.3 31.1 11.2 32.4 84 99 A T > - 0 0 17 -2,-0.4 4,-3.6 54,-0.1 5,-0.2 -0.406 45.9 -94.4 -75.6 166.8 32.4 12.1 35.9 85 100 A K H > S+ 0 0 65 1,-0.3 4,-2.4 2,-0.2 5,-0.2 0.847 130.3 47.1 -53.2 -36.3 35.1 14.8 36.1 86 101 A A H > S+ 0 0 56 2,-0.2 4,-3.1 3,-0.2 5,-0.3 0.854 111.5 49.8 -78.4 -33.2 37.8 12.1 36.1 87 102 A D H > S+ 0 0 68 -3,-0.2 4,-2.6 2,-0.2 5,-0.5 0.965 113.3 48.0 -59.2 -51.3 36.1 10.3 33.1 88 103 A L H X S+ 0 0 0 -4,-3.6 4,-1.3 1,-0.2 5,-0.3 0.939 117.0 41.2 -56.7 -52.7 36.0 13.7 31.4 89 104 A I H X S+ 0 0 29 -4,-2.4 4,-1.2 -5,-0.2 -1,-0.2 0.911 121.0 41.1 -69.3 -44.6 39.6 14.4 32.2 90 105 A N H X S+ 0 0 91 -4,-3.1 4,-1.8 1,-0.2 6,-0.3 0.981 116.6 41.9 -70.7 -56.9 41.0 11.0 31.5 91 106 A N H < S+ 0 0 92 -4,-2.6 -1,-0.2 -5,-0.3 -2,-0.2 0.646 121.0 41.3 -81.2 -0.5 39.2 9.8 28.4 92 107 A L H < S+ 0 0 13 -4,-1.3 -1,-0.2 -5,-0.5 -2,-0.2 0.693 126.1 30.0 -95.6 -23.3 39.4 13.1 26.6 93 108 A G H < S- 0 0 0 -4,-1.2 -85,-2.5 -5,-0.3 -82,-0.2 0.565 137.1 -11.3-114.8 -4.6 43.0 14.1 27.4 94 109 A T S < S+ 0 0 61 -4,-1.8 2,-1.6 -87,-0.1 -3,-0.1 0.075 91.4 96.5-154.1-108.1 44.9 10.8 27.9 95 110 A I S S+ 0 0 61 1,-0.3 3,-0.3 2,-0.2 4,-0.1 0.119 95.5 44.2 36.8 -61.0 43.2 7.3 28.1 96 111 A A > + 0 0 28 -2,-1.6 4,-0.7 -6,-0.3 -1,-0.3 -0.352 65.2 130.5-105.1 44.6 43.6 6.3 24.4 97 112 A K T 4 S+ 0 0 26 2,-0.1 4,-0.4 1,-0.1 -1,-0.2 0.745 83.8 48.3 -47.3 -25.0 47.1 7.6 24.6 98 113 A S T >> S+ 0 0 89 -3,-0.3 3,-2.0 2,-0.2 4,-1.5 0.971 101.0 52.0 -85.3 -66.2 47.1 4.1 23.0 99 114 A G H 3> S+ 0 0 12 1,-0.3 4,-1.1 2,-0.2 22,-0.2 0.585 108.4 61.5 -50.1 -9.9 44.4 3.9 20.2 100 115 A T H 3X S+ 0 0 0 -4,-0.7 4,-1.6 2,-0.2 -1,-0.3 0.735 99.1 48.1 -91.4 -31.6 46.1 7.0 18.9 101 116 A K H <> S+ 0 0 101 -3,-2.0 4,-1.6 -4,-0.4 3,-0.4 0.969 111.8 52.4 -73.1 -55.4 49.5 5.6 18.2 102 117 A A H >X S+ 0 0 36 -4,-1.5 4,-2.6 1,-0.2 3,-0.6 0.881 110.4 48.7 -36.2 -54.6 47.9 2.7 16.4 103 118 A F H 3X S+ 0 0 1 -4,-1.1 4,-1.3 1,-0.2 -1,-0.2 0.906 107.4 54.5 -59.4 -42.6 45.9 5.1 14.2 104 119 A M H 3< S+ 0 0 26 -4,-1.6 4,-0.2 -3,-0.4 -1,-0.2 0.658 112.5 41.5 -78.0 -16.1 48.9 7.2 13.3 105 120 A E H X< S+ 0 0 85 -4,-1.6 3,-3.9 -3,-0.6 6,-0.2 0.883 108.8 60.3 -80.1 -58.3 50.9 4.3 12.0 106 121 A A H 3<>S+ 0 0 25 -4,-2.6 5,-0.6 1,-0.3 -2,-0.2 0.752 91.8 70.7 -32.3 -33.0 47.8 2.9 10.4 107 122 A L T 3X5S+ 0 0 28 -4,-1.3 4,-0.6 -5,-0.2 2,-0.4 0.830 93.5 58.9 -65.7 -31.7 47.8 6.2 8.4 108 123 A Q T <45S+ 0 0 127 -3,-3.9 4,-0.1 -4,-0.2 0, 0.0 -0.853 91.3 59.2 -89.6 136.0 50.8 5.0 6.6 109 124 A A T 45S- 0 0 94 -2,-0.4 -1,-0.2 2,-0.1 3,-0.1 0.608 134.7 -79.4 101.3 31.8 49.7 1.8 4.9 110 125 A G T 45S+ 0 0 81 -3,-0.2 2,-0.4 1,-0.1 -2,-0.2 0.836 84.0 151.0 32.2 55.4 47.0 3.9 3.1 111 126 A A << - 0 0 18 -4,-0.6 2,-0.3 -5,-0.6 -1,-0.1 -0.851 32.7-151.9 -93.3 148.1 44.7 4.1 6.0 112 127 A D > - 0 0 66 -2,-0.4 3,-3.1 -3,-0.1 -4,-0.0 -0.919 27.2 -98.9-127.9 163.5 42.8 7.3 5.7 113 128 A I G > S+ 0 0 8 -2,-0.3 3,-1.8 1,-0.3 12,-0.1 0.713 111.9 73.9 -48.5 -28.4 41.2 9.6 8.3 114 129 A S G 3 S+ 0 0 29 1,-0.3 3,-0.4 2,-0.1 -1,-0.3 0.650 89.6 59.7 -68.5 -12.0 37.8 8.1 7.7 115 130 A M G X S+ 0 0 66 -3,-3.1 3,-0.8 1,-0.2 -1,-0.3 0.064 70.4 112.4-100.6 27.0 38.7 5.0 9.5 116 131 A I G X > + 0 0 0 -3,-1.8 3,-1.4 1,-0.2 5,-1.2 0.764 63.9 66.5 -67.8 -30.3 39.5 6.8 12.8 117 132 A G G > 5S+ 0 0 31 -3,-0.4 3,-1.4 1,-0.3 -1,-0.2 0.745 85.7 72.5 -65.1 -23.7 36.6 5.3 14.7 118 133 A Q G < 5S+ 0 0 134 -3,-0.8 -1,-0.3 1,-0.3 -2,-0.2 0.694 99.7 46.1 -65.9 -17.1 38.2 1.9 14.6 119 134 A F G < 5S- 0 0 64 -3,-1.4 -1,-0.3 -4,-0.2 -2,-0.2 0.305 117.1-108.2-112.5 7.8 40.8 3.0 17.1 120 135 A G T < 5S+ 0 0 61 -3,-1.4 -3,-0.2 -4,-0.1 -2,-0.1 0.701 95.7 97.9 78.0 25.2 38.4 4.7 19.6 121 136 A V > < + 0 0 4 -5,-1.2 3,-1.7 -22,-0.2 4,-0.4 0.173 34.1 122.6-130.3 22.3 39.4 8.2 18.8 122 137 A G G > + 0 0 1 1,-0.3 3,-2.2 -6,-0.2 4,-0.3 0.797 61.6 75.1 -51.4 -33.8 36.7 9.3 16.5 123 138 A F G > S+ 0 0 20 1,-0.3 3,-2.3 -91,-0.2 -1,-0.3 0.876 85.7 64.2 -52.0 -38.8 35.7 12.1 18.7 124 139 A Y G X S+ 0 0 10 -3,-1.7 3,-2.3 1,-0.3 -1,-0.3 0.734 81.6 78.2 -65.9 -17.7 38.7 14.1 17.6 125 140 A S G X> S+ 0 0 0 -3,-2.2 3,-3.0 -4,-0.4 4,-0.5 0.756 70.8 82.4 -57.8 -20.1 37.4 14.2 14.0 126 141 A A H X> S+ 0 0 0 -3,-2.3 4,-2.3 -4,-0.3 3,-1.7 0.864 79.9 69.1 -54.7 -26.4 35.1 17.0 15.3 127 142 A Y H <4 S+ 0 0 1 -3,-2.3 -1,-0.3 1,-0.3 -2,-0.2 0.680 80.1 73.9 -70.4 -15.4 38.3 19.0 14.7 128 143 A L H <4 S+ 0 0 0 -3,-3.0 -1,-0.3 -4,-0.2 -2,-0.2 0.833 118.6 15.5 -53.0 -36.9 37.8 18.5 10.8 129 144 A V H << S+ 0 0 0 -3,-1.7 47,-4.6 -4,-0.5 2,-0.4 0.688 115.4 72.3-115.5 -16.9 35.0 21.0 11.1 130 145 A A E < -E 175 0A 2 -4,-2.3 45,-0.3 45,-0.3 3,-0.1 -0.850 47.2-163.8-110.6 135.2 35.2 22.9 14.4 131 146 A E E S+ 0 0 106 43,-2.1 2,-0.3 -2,-0.4 44,-0.2 0.647 91.4 20.4 -76.4 -18.3 37.6 25.6 15.6 132 147 A K E -E 174 0A 63 42,-1.3 42,-2.7 -6,-0.1 2,-0.4 -0.986 66.8-161.1-150.2 138.6 36.4 24.9 19.1 133 148 A V E -EF 173 149A 0 16,-2.3 16,-2.3 -2,-0.3 2,-0.4 -0.990 4.2-169.5-122.5 135.0 34.6 22.0 20.8 134 149 A T E -EF 172 148A 10 38,-2.1 38,-3.5 -2,-0.4 2,-0.6 -0.983 4.3-162.9-118.7 130.7 32.7 22.1 24.1 135 150 A V E -EF 171 147A 3 12,-1.9 12,-2.6 -2,-0.4 2,-0.6 -0.942 2.4-169.8-114.0 114.0 31.5 19.0 25.9 136 151 A I E +EF 170 146A 14 34,-3.4 34,-3.7 -2,-0.6 2,-0.3 -0.915 18.2 175.0-100.2 121.3 28.8 19.4 28.5 137 152 A T E -EF 169 145A 0 8,-2.5 8,-1.7 -2,-0.6 2,-0.4 -0.927 20.3-172.6-131.2 145.9 28.4 16.1 30.5 138 153 A K E -EF 168 144A 48 30,-2.7 30,-2.7 -2,-0.3 2,-0.2 -0.940 12.1-169.6-140.9 119.1 26.3 15.0 33.6 139 154 A H - 0 0 21 4,-0.7 -57,-0.2 -2,-0.4 3,-0.1 -0.688 35.5-114.9-103.4 158.3 26.8 11.6 35.1 140 155 A N S S+ 0 0 53 -59,-0.6 -1,-0.1 -2,-0.2 -58,-0.1 0.974 114.8 49.2 -57.1 -48.2 24.8 9.8 37.7 141 156 A D S S+ 0 0 135 -3,-0.0 -1,-0.2 2,-0.0 2,-0.1 0.858 114.2 23.2 -49.3 -42.6 27.7 10.0 40.2 142 157 A D S S- 0 0 37 1,-0.3 -58,-0.0 -3,-0.1 -59,-0.0 -0.211 79.7 -65.5-129.4-172.8 28.7 13.6 39.9 143 158 A E - 0 0 111 -5,-0.1 -4,-0.7 -2,-0.1 2,-0.6 -0.091 57.8 -94.1 -65.9-179.3 28.3 17.3 39.1 144 159 A Q E -F 138 0A 16 16,-0.2 16,-3.7 -6,-0.2 2,-0.3 -0.916 48.1-168.7-105.1 122.7 27.7 18.8 35.7 145 160 A Y E -FG 137 159A 17 -8,-1.7 -8,-2.5 -2,-0.6 2,-0.5 -0.864 20.7-147.2-119.3 147.9 31.0 19.8 33.9 146 161 A A E -FG 136 158A 9 12,-2.3 12,-2.1 -2,-0.3 2,-0.3 -0.960 15.5-168.8-107.9 116.5 32.0 21.7 30.8 147 162 A W E -FG 135 157A 0 -12,-2.6 -12,-1.9 -2,-0.5 2,-0.3 -0.760 14.6-175.6 -94.8 148.8 35.1 20.5 29.0 148 163 A E E +FG 134 156A 51 8,-2.3 8,-2.7 -2,-0.3 2,-0.3 -0.984 13.0 159.6-153.3 145.6 36.5 22.8 26.3 149 164 A S E -F 133 0A 5 -16,-2.3 -16,-2.3 -2,-0.3 6,-0.1 -0.847 31.2-175.1-168.1 136.2 39.2 23.1 23.7 150 165 A S - 0 0 72 1,-0.5 5,-0.1 -2,-0.3 -18,-0.1 -0.163 60.6-119.0-107.8 31.3 40.3 24.8 20.5 151 166 A A > + 0 0 15 3,-0.2 3,-0.7 -18,-0.1 -1,-0.5 -0.278 69.2 132.0 67.5-149.6 43.3 22.4 20.4 152 167 A G T 3 S- 0 0 83 1,-0.2 -1,-0.1 -140,-0.2 3,-0.1 0.674 99.1 -59.0 70.4 18.0 46.7 24.0 20.5 153 168 A G T 3 S+ 0 0 32 1,-0.2 -146,-3.6 -141,-0.1 2,-0.3 -0.024 115.5 63.2 108.6 -28.6 48.0 21.6 23.2 154 169 A S E < -A 6 0A 51 -3,-0.7 2,-0.3 -148,-0.3 -4,-0.2 -0.851 49.1-167.3-131.2 162.7 45.5 22.1 26.1 155 170 A F E -A 5 0A 5 -150,-2.2 -150,-3.6 -2,-0.3 2,-0.4 -0.924 17.0-133.4-137.1 166.2 41.9 21.9 27.2 156 171 A T E -AG 4 148A 27 -8,-2.7 -8,-2.3 -2,-0.3 2,-0.4 -0.962 7.6-162.6-123.9 144.8 39.9 23.2 30.2 157 172 A V E +AG 3 147A 3 -154,-2.0 -154,-2.9 -2,-0.4 2,-0.3 -0.989 18.0 162.2-117.0 133.9 37.4 21.8 32.6 158 173 A R E -AG 2 146A 99 -12,-2.1 -12,-2.3 -2,-0.4 2,-0.3 -0.923 48.4 -96.3-134.3 156.4 35.1 23.9 34.8 159 174 A T E - G 0 145A 79 -158,-0.6 2,-0.5 -2,-0.3 -14,-0.3 -0.641 52.0-106.3 -73.7 137.6 31.9 22.9 36.6 160 175 A D - 0 0 39 -16,-3.7 -16,-0.2 -2,-0.3 -1,-0.1 -0.560 33.7-177.1 -77.3 119.9 28.9 23.8 34.3 161 176 A T + 0 0 139 -2,-0.5 -1,-0.1 3,-0.0 -16,-0.1 0.200 60.9 86.5 -92.0 12.5 26.9 26.8 35.5 162 177 A G S S- 0 0 33 1,-0.2 -18,-0.0 -18,-0.1 3,-0.0 0.203 91.5 -19.0 -95.7-148.7 24.5 26.3 32.5 163 178 A E - 0 0 143 2,-0.1 -1,-0.2 1,-0.0 -3,-0.0 -0.455 65.5-130.9 -58.8 100.1 21.3 24.4 31.8 164 179 A P - 0 0 104 0, 0.0 3,-0.1 0, 0.0 -26,-0.0 -0.212 29.7-164.0 -39.1 150.5 21.2 21.6 34.3 165 180 A M - 0 0 35 1,-0.1 2,-2.0 3,-0.1 -27,-0.1 -0.183 23.0-121.9-155.0 57.4 20.6 18.5 32.1 166 181 A G S S- 0 0 46 -110,-0.0 2,-0.2 -108,-0.0 -1,-0.1 -0.095 75.9 -38.8 57.9 -78.2 19.3 15.2 33.5 167 182 A R S S+ 0 0 6 -2,-2.0 2,-0.3 -89,-0.1 -28,-0.2 -0.813 94.7 56.1 176.8 143.2 22.1 12.9 32.4 168 183 A G E S- E 0 138A 0 -30,-2.7 -30,-2.7 -89,-0.2 -85,-0.4 -0.874 72.5 -67.6 122.6-163.2 24.2 12.5 29.3 169 184 A T E -DE 78 137A 14 -91,-1.3 -91,-2.3 -2,-0.3 2,-0.5 -0.998 24.4-158.5-140.8 133.9 26.6 14.5 27.2 170 185 A K E -DE 77 136A 59 -34,-3.7 -34,-3.4 -2,-0.4 2,-0.7 -0.979 8.3-162.3-111.3 123.9 26.2 17.5 24.8 171 186 A V E -DE 76 135A 13 -95,-2.9 -95,-2.4 -2,-0.5 2,-0.7 -0.922 8.0-165.5-102.7 111.2 29.0 18.1 22.2 172 187 A I E -DE 75 134A 33 -38,-3.5 -38,-2.1 -2,-0.7 2,-0.8 -0.854 3.2-158.0 -97.3 113.9 28.9 21.7 20.9 173 188 A L E -DE 74 133A 0 -99,-3.4 -99,-1.7 -2,-0.7 2,-1.0 -0.818 7.7-155.6 -94.2 117.1 30.8 22.3 17.7 174 189 A H E -DE 73 132A 41 -42,-2.7 -43,-2.1 -2,-0.8 -42,-1.3 -0.804 34.5-133.3 -84.3 103.6 31.8 25.8 17.0 175 190 A L E - E 0 130A 0 -103,-2.0 -45,-0.3 -2,-1.0 5,-0.1 -0.166 10.3-107.0 -71.2 145.7 32.1 25.4 13.3 176 191 A K > - 0 0 50 -47,-4.6 3,-2.3 1,-0.1 -1,-0.1 -0.424 41.0-107.9 -60.5 151.4 35.0 26.6 11.2 177 192 A E T 3 S+ 0 0 144 1,-0.3 3,-0.3 2,-0.1 -1,-0.1 0.648 117.9 44.2 -60.4 -21.9 33.8 29.6 9.2 178 193 A D T 3 S+ 0 0 111 1,-0.1 -1,-0.3 -49,-0.1 3,-0.1 0.092 100.7 70.8-109.3 21.6 33.8 27.8 5.9 179 194 A Q X + 0 0 15 -3,-2.3 3,-1.9 -50,-0.2 -2,-0.1 0.028 54.9 119.8-120.9 24.8 32.0 24.6 7.3 180 195 A T G > + 0 0 59 1,-0.3 3,-2.0 -3,-0.3 4,-0.2 0.636 51.8 87.5 -69.0 -6.4 28.7 26.1 7.8 181 196 A E G > S+ 0 0 75 1,-0.3 3,-1.2 2,-0.2 -1,-0.3 0.743 78.7 65.6 -57.0 -17.8 27.2 23.6 5.4 182 197 A Y G < S+ 0 0 7 -3,-1.9 -1,-0.3 1,-0.3 -2,-0.2 0.512 89.9 65.0 -89.7 -0.9 26.9 21.4 8.4 183 198 A L G < S+ 0 0 6 -3,-2.0 2,-0.4 -116,-0.1 -1,-0.3 0.408 83.8 102.8 -82.9 -8.3 24.3 23.7 9.9 184 199 A E S <> S- 0 0 79 -3,-1.2 4,-3.3 -4,-0.2 5,-0.2 -0.704 70.9-136.3-100.9 135.5 21.9 23.0 7.0 185 200 A E H > S+ 0 0 99 -2,-0.4 4,-2.6 1,-0.2 5,-0.2 0.854 103.5 40.7 -56.0 -49.0 18.9 20.8 7.3 186 201 A R H > S+ 0 0 206 2,-0.2 4,-3.1 1,-0.2 -1,-0.2 0.897 113.9 54.5 -69.6 -35.4 19.3 18.8 4.0 187 202 A R H > S+ 0 0 38 2,-0.2 4,-2.2 1,-0.2 -2,-0.2 0.973 112.3 44.2 -61.4 -48.6 23.1 18.6 4.5 188 203 A I H X S+ 0 0 3 -4,-3.3 4,-2.9 1,-0.2 5,-0.3 0.930 113.6 49.0 -64.7 -47.2 22.6 17.0 7.9 189 204 A K H X S+ 0 0 122 -4,-2.6 4,-3.0 1,-0.2 5,-0.3 0.907 109.4 53.1 -55.2 -50.2 19.8 14.7 6.8 190 205 A E H X S+ 0 0 105 -4,-3.1 4,-2.5 -5,-0.2 -1,-0.2 0.932 112.4 44.9 -51.7 -45.1 21.9 13.5 3.9 191 206 A I H X S+ 0 0 1 -4,-2.2 4,-2.7 -5,-0.2 5,-0.4 0.939 115.4 45.0 -71.2 -41.3 24.7 12.7 6.2 192 207 A V H X S+ 0 0 28 -4,-2.9 4,-2.3 2,-0.2 -1,-0.2 0.952 115.5 48.9 -58.2 -47.1 22.7 10.9 8.9 193 208 A K H < S+ 0 0 154 -4,-3.0 4,-0.3 -5,-0.3 -2,-0.2 0.902 116.1 44.0 -69.1 -33.0 20.8 9.1 6.3 194 209 A K H < S+ 0 0 120 -4,-2.5 -1,-0.2 -5,-0.3 -2,-0.2 0.879 129.2 17.3 -74.0 -41.4 24.1 8.1 4.6 195 210 A H H < S+ 0 0 58 -4,-2.7 -3,-0.2 -5,-0.2 -2,-0.2 0.538 132.1 32.6-113.9 -11.2 26.3 7.0 7.6 196 211 A S >< + 0 0 11 -4,-2.3 3,-1.1 -5,-0.4 -3,-0.1 -0.053 68.7 128.5-140.5 32.5 24.0 6.4 10.5 197 212 A Q T 3 S+ 0 0 105 -4,-0.3 -4,-0.1 1,-0.3 -1,-0.1 0.683 76.8 47.0 -72.7 -11.8 20.8 5.1 9.1 198 213 A F T 3 S+ 0 0 178 -3,-0.1 -1,-0.3 2,-0.0 2,-0.2 -0.025 72.7 142.2-123.3 37.8 20.7 2.1 11.4 199 214 A I < - 0 0 49 -3,-1.1 4,-0.1 1,-0.1 -3,-0.0 -0.502 55.1-125.2 -73.9 141.6 21.4 3.5 14.8 200 215 A G S S+ 0 0 68 -2,-0.2 -1,-0.1 2,-0.1 -2,-0.0 0.414 84.9 56.9 -66.5 2.8 19.4 1.9 17.7 201 216 A Y S S- 0 0 21 -139,-0.0 -139,-0.1 -138,-0.0 -2,-0.1 -0.942 94.1 -88.1-139.4 149.2 18.0 5.1 19.1 202 217 A P - 0 0 87 0, 0.0 -139,-2.5 0, 0.0 2,-0.5 -0.316 34.9-159.9 -63.3 144.5 15.9 7.9 17.8 203 218 A I E -c 63 0A 43 -141,-0.2 2,-0.6 -4,-0.1 -139,-0.2 -0.970 6.2-164.9-119.4 119.6 17.8 10.8 16.3 204 219 A T E -c 64 0A 65 -141,-2.3 -139,-2.9 -2,-0.5 2,-0.7 -0.901 8.2-155.2-112.7 125.7 15.9 14.0 16.1 205 220 A L E -c 65 0A 41 -2,-0.6 -139,-0.2 -141,-0.2 2,-0.1 -0.896 21.0-142.6 -94.9 117.0 17.2 16.7 13.8 206 221 A F - 0 0 80 -141,-2.8 2,-0.3 -2,-0.7 -142,-0.0 -0.464 6.2-134.3 -74.4 152.3 15.8 20.0 15.2 207 222 A V 0 0 99 -2,-0.1 -1,-0.0 -141,-0.1 0, 0.0 -0.702 360.0 360.0-105.9 158.1 14.7 22.9 13.0 208 223 A E 0 0 119 -2,-0.3 -140,-0.1 -142,-0.0 -142,-0.0 -0.675 360.0 360.0-102.8 360.0 15.7 26.4 13.6