==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=19-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 19-AUG-04 1WOJ . COMPND 2 MOLECULE: 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR Y.SAKAMOTO,N.TANAKA,T.ICHIMIYA,T.KURIHARA,K.T.NAKAMURA . 209 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 11029.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 150 71.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 57 27.3 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 3 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 18 8.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 23 11.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 46 22.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 1.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 2 1 2 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 0 0 1 2 3 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 166 A L 0 0 62 0, 0.0 76,-0.1 0, 0.0 75,-0.0 0.000 360.0 360.0 360.0 156.6 19.3 31.1 -14.6 2 167 A P - 0 0 0 0, 0.0 68,-2.0 0, 0.0 69,-0.4 -0.155 360.0-111.6 -72.5 171.4 19.9 33.2 -11.5 3 168 A L S S- 0 0 36 205,-2.2 66,-2.5 1,-0.3 65,-2.3 0.893 98.3 -21.0 -62.9 -46.0 23.2 33.9 -9.8 4 169 A Y E -AB 67 208A 32 204,-1.5 204,-2.9 63,-0.3 -1,-0.3 -0.981 60.3-129.1-158.2 158.4 21.7 31.8 -6.9 5 170 A F E + B 0 207A 8 61,-2.2 60,-2.2 -2,-0.3 2,-0.3 -0.726 44.1 123.8 -98.3 160.7 18.4 30.7 -5.5 6 171 A G E -AB 64 206A 0 200,-2.0 200,-2.7 58,-0.3 2,-0.6 -0.974 59.9 -66.3 172.2-178.5 17.4 31.1 -1.9 7 172 A W E -AB 63 205A 0 56,-2.6 56,-2.4 -2,-0.3 2,-0.6 -0.870 42.0-157.5 -95.3 120.4 15.0 32.4 0.8 8 173 A F E -AB 62 204A 29 196,-2.8 196,-2.5 -2,-0.6 54,-0.2 -0.892 17.6-126.8-106.8 116.9 14.8 36.2 0.9 9 174 A L E - B 0 203A 4 52,-2.3 194,-0.3 -2,-0.6 52,-0.1 -0.198 22.1-110.1 -62.0 145.8 13.6 37.7 4.1 10 175 A T > - 0 0 35 192,-2.0 4,-2.8 1,-0.1 51,-0.3 -0.270 36.5-102.8 -62.5 162.4 10.7 40.2 4.3 11 176 A K H > S+ 0 0 150 1,-0.2 4,-2.3 2,-0.2 5,-0.2 0.934 122.8 46.7 -52.1 -48.4 11.6 43.7 5.2 12 177 A K H > S+ 0 0 146 1,-0.2 4,-2.1 2,-0.2 -1,-0.2 0.916 113.9 46.1 -66.2 -44.3 10.4 43.2 8.8 13 178 A S H > S+ 0 0 10 2,-0.2 4,-2.2 1,-0.2 5,-0.2 0.879 112.2 51.9 -66.1 -38.2 12.2 39.9 9.3 14 179 A S H X S+ 0 0 2 -4,-2.8 4,-2.7 1,-0.2 -2,-0.2 0.916 111.1 47.3 -61.6 -45.3 15.4 41.3 7.8 15 180 A E H X S+ 0 0 106 -4,-2.3 4,-2.0 -5,-0.2 -2,-0.2 0.871 111.6 51.6 -64.7 -38.8 15.3 44.3 10.2 16 181 A T H X S+ 0 0 67 -4,-2.1 4,-2.0 2,-0.2 -2,-0.2 0.918 115.0 40.4 -65.0 -47.0 14.6 42.0 13.2 17 182 A L H X S+ 0 0 0 -4,-2.2 4,-2.7 2,-0.2 -2,-0.2 0.886 112.9 54.5 -72.1 -40.2 17.5 39.7 12.5 18 183 A R H X S+ 0 0 63 -4,-2.7 4,-2.3 -5,-0.2 -2,-0.2 0.915 110.9 46.8 -57.0 -43.3 19.8 42.6 11.6 19 184 A K H X S+ 0 0 122 -4,-2.0 4,-2.5 2,-0.2 -2,-0.2 0.900 110.6 51.4 -67.9 -41.5 19.1 44.3 14.9 20 185 A A H X S+ 0 0 6 -4,-2.0 4,-2.2 1,-0.2 -2,-0.2 0.912 111.4 49.2 -59.9 -44.4 19.6 41.0 16.8 21 186 A G H X S+ 0 0 4 -4,-2.7 4,-2.3 2,-0.2 -2,-0.2 0.913 111.3 48.8 -57.2 -46.2 22.9 40.6 15.0 22 187 A Q H X S+ 0 0 74 -4,-2.3 4,-2.5 2,-0.2 -2,-0.2 0.912 111.0 48.9 -65.6 -44.1 24.0 44.2 15.9 23 188 A V H X S+ 0 0 36 -4,-2.5 4,-2.8 2,-0.2 5,-0.2 0.899 110.6 52.4 -61.9 -41.3 23.0 43.8 19.6 24 189 A F H X S+ 0 0 3 -4,-2.2 4,-2.8 -5,-0.2 5,-0.2 0.936 111.4 46.1 -58.3 -47.6 25.0 40.5 19.7 25 190 A L H X S+ 0 0 12 -4,-2.3 4,-2.2 2,-0.2 24,-0.4 0.891 113.5 49.4 -64.1 -40.6 28.1 42.3 18.2 26 191 A E H X S+ 0 0 82 -4,-2.5 4,-1.0 1,-0.2 -2,-0.2 0.935 116.3 41.0 -64.8 -47.8 27.7 45.2 20.6 27 192 A E H X S+ 0 0 58 -4,-2.8 4,-0.5 2,-0.2 -2,-0.2 0.878 114.1 52.0 -69.9 -38.6 27.4 43.0 23.7 28 193 A L H >< S+ 0 0 0 -4,-2.8 3,-1.3 -5,-0.2 6,-0.3 0.929 107.3 52.3 -66.3 -45.8 30.1 40.5 22.6 29 194 A G H 3< S+ 0 0 5 -4,-2.2 18,-0.3 1,-0.3 -1,-0.2 0.775 113.3 45.2 -61.5 -26.8 32.6 43.3 22.0 30 195 A N H 3< S+ 0 0 98 -4,-1.0 -1,-0.3 -3,-0.2 2,-0.2 0.476 91.2 108.7 -93.3 -4.7 31.9 44.6 25.5 31 196 A H S S+ 0 0 142 1,-0.2 4,-1.9 -2,-0.2 5,-0.1 0.847 105.9 57.0 -57.7 -38.6 35.0 40.3 29.4 33 198 A A H > S+ 0 0 14 1,-0.2 4,-0.8 2,-0.2 -1,-0.2 0.904 109.4 44.7 -60.0 -45.5 35.5 36.9 27.7 34 199 A F H >4 S+ 0 0 1 -3,-0.4 3,-0.8 -6,-0.3 -1,-0.2 0.901 109.9 55.1 -65.6 -42.2 35.9 38.6 24.3 35 200 A K H >< S+ 0 0 82 -4,-2.2 3,-1.2 1,-0.3 -2,-0.2 0.868 103.7 55.5 -61.3 -35.4 38.2 41.3 25.7 36 201 A K H 3< S+ 0 0 154 -4,-1.9 3,-0.3 1,-0.2 -1,-0.3 0.777 111.2 45.3 -65.7 -27.1 40.5 38.5 27.1 37 202 A E T XX S+ 0 0 58 -3,-0.8 3,-1.7 -4,-0.8 4,-0.6 0.197 75.1 118.4-101.7 13.5 40.8 37.0 23.6 38 203 A L H X> S+ 0 0 31 -3,-1.2 4,-2.9 1,-0.3 3,-0.5 0.777 75.0 50.7 -57.6 -34.7 41.4 40.2 21.6 39 204 A R H 34 S+ 0 0 190 -3,-0.3 -1,-0.3 1,-0.2 -2,-0.1 0.629 107.0 54.9 -80.0 -14.5 44.8 39.2 20.3 40 205 A Q H <4 S+ 0 0 90 -3,-1.7 -1,-0.2 2,-0.1 -2,-0.2 0.501 116.1 40.1 -86.6 -9.9 43.4 35.9 19.1 41 206 A F H << S+ 0 0 8 -4,-0.6 -2,-0.2 -3,-0.5 -3,-0.1 0.832 133.1 11.6-101.5 -53.7 40.8 37.9 17.2 42 207 A V < 0 0 46 -4,-2.9 -1,-0.2 -5,-0.1 -2,-0.1 -0.882 360.0 360.0-132.7 97.7 42.9 40.8 15.8 43 208 A P 0 0 160 0, 0.0 -1,-0.1 0, 0.0 -3,-0.1 0.808 360.0 360.0 -75.6 360.0 46.7 40.7 16.1 44 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 45 214 A E 0 0 212 0, 0.0 2,-0.2 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 93.4 42.2 48.5 22.5 46 215 A K - 0 0 135 1,-0.1 2,-0.4 -16,-0.0 -16,-0.1 -0.519 360.0-135.0 -69.1 134.2 38.5 47.5 22.7 47 216 A M - 0 0 43 -18,-0.3 2,-0.9 -2,-0.2 3,-0.1 -0.775 3.1-141.0-101.8 129.8 37.1 46.6 19.3 48 217 A D > - 0 0 95 -2,-0.4 4,-2.1 1,-0.2 3,-0.2 -0.800 17.3-167.3 -86.1 104.5 33.8 47.9 17.9 49 218 A L H > S+ 0 0 2 -2,-0.9 4,-2.2 -24,-0.4 -1,-0.2 0.744 82.5 61.9 -73.2 -24.3 32.6 44.7 16.1 50 219 A V H 4 S+ 0 0 23 2,-0.2 -1,-0.2 1,-0.2 -2,-0.0 0.924 111.9 40.7 -63.1 -41.7 29.8 46.5 14.2 51 220 A T H 4 S+ 0 0 89 -3,-0.2 3,-0.4 1,-0.2 -2,-0.2 0.870 110.6 57.7 -68.4 -41.9 32.6 48.5 12.6 52 221 A Y H < S+ 0 0 55 -4,-2.1 2,-1.7 1,-0.3 96,-0.4 0.912 102.4 55.3 -56.0 -45.3 34.9 45.5 12.2 53 222 A F S < S+ 0 0 3 -4,-2.2 -1,-0.3 1,-0.2 94,-0.2 -0.428 74.8 157.1 -88.3 63.4 32.2 43.7 10.2 54 223 A G + 0 0 43 -2,-1.7 2,-0.8 -3,-0.4 -1,-0.2 0.635 49.9 71.7 -73.3 -22.2 32.1 46.6 7.8 55 224 A K B +C 146 0A 96 91,-2.0 91,-2.2 -3,-0.2 -1,-0.1 -0.876 68.9 158.5 -95.5 108.1 30.7 44.8 4.7 56 225 A R - 0 0 125 -2,-0.8 89,-0.2 89,-0.2 88,-0.1 -0.914 51.3 -92.8-127.9 153.2 27.1 44.1 5.6 57 226 A P - 0 0 32 0, 0.0 4,-0.1 0, 0.0 -2,-0.0 -0.510 36.2-144.6 -56.9 129.4 23.9 43.4 3.6 58 227 A P - 0 0 134 0, 0.0 3,-0.1 0, 0.0 -3,-0.0 0.771 69.8 -28.3 -72.7 -28.0 22.3 46.8 3.1 59 228 A G S S+ 0 0 35 1,-0.4 2,-0.3 -41,-0.0 -41,-0.1 0.148 115.9 50.6-149.1 -92.4 18.6 45.7 3.4 60 229 A V - 0 0 82 -52,-0.0 -1,-0.4 1,-0.0 2,-0.2 -0.481 65.1-152.0 -72.0 128.3 17.0 42.4 2.5 61 230 A L - 0 0 0 -2,-0.3 -52,-2.3 -51,-0.3 2,-0.3 -0.560 14.9-166.5 -93.4 161.2 18.8 39.4 4.1 62 231 A H E -A 8 0A 50 81,-0.3 81,-0.6 -54,-0.2 2,-0.5 -0.983 27.1-142.0-148.1 162.1 18.8 35.9 2.6 63 232 A C E -A 7 0A 0 -56,-2.4 -56,-2.6 -2,-0.3 79,-0.2 -0.971 33.5-142.2-122.8 104.5 19.6 32.2 3.1 64 233 A T E +A 6 0A 34 -2,-0.5 -58,-0.3 77,-0.4 77,-0.3 -0.444 23.8 176.0 -68.5 141.0 21.1 30.8 -0.1 65 234 A T E + 0 0 7 -60,-2.2 2,-0.5 1,-0.3 -59,-0.2 0.707 68.0 12.9 -99.2 -78.0 20.2 27.3 -1.3 66 235 A K E - 0 0 30 54,-0.1 -61,-2.2 55,-0.1 2,-0.5 -0.896 62.9-144.2-112.1 120.2 21.9 26.6 -4.7 67 236 A F E +A 4 0A 105 -2,-0.5 -63,-0.3 -63,-0.2 -64,-0.1 -0.707 25.6 172.3 -75.0 122.9 24.6 28.8 -6.2 68 237 A C > > - 0 0 0 -65,-2.3 5,-2.3 -2,-0.5 3,-1.4 0.729 24.4-152.5-109.3 -30.3 23.9 28.7 -9.9 69 238 A D G > 5S- 0 0 50 -66,-2.5 3,-1.7 1,-0.3 -66,-0.3 0.891 75.4 -59.3 52.5 45.5 26.3 31.3 -11.5 70 239 A Y G 3 5S- 0 0 116 -68,-2.0 -1,-0.3 1,-0.3 -67,-0.2 0.735 108.8 -44.1 55.1 29.4 23.8 31.8 -14.3 71 240 A G G < 5S+ 0 0 36 -3,-1.4 6,-0.3 -69,-0.4 -1,-0.3 0.267 122.1 99.4 103.6 -8.8 24.0 28.1 -15.3 72 241 A K T < 5 + 0 0 152 -3,-1.7 -3,-0.2 -4,-0.3 -2,-0.1 0.690 58.2 90.8 -83.8 -22.9 27.8 27.6 -15.0 73 242 A A S > S+ 0 0 44 -4,-0.2 4,-2.4 -3,-0.0 5,-0.2 0.397 88.6 121.7 83.7 1.8 23.9 21.0 -11.3 76 245 A A H <> S+ 0 0 1 -3,-2.2 4,-2.6 2,-0.2 5,-0.2 0.944 75.7 45.1 -61.7 -50.8 22.4 24.5 -11.6 77 246 A E H > S+ 0 0 123 -6,-0.3 4,-1.4 -4,-0.3 -1,-0.2 0.913 113.8 49.7 -59.9 -45.1 20.1 23.6 -14.5 78 247 A E H > S+ 0 0 134 1,-0.2 4,-0.6 2,-0.2 -1,-0.2 0.901 111.9 48.7 -60.0 -44.9 19.0 20.3 -12.8 79 248 A Y H >< S+ 0 0 12 -4,-2.4 3,-1.2 1,-0.2 6,-0.2 0.934 110.9 50.4 -58.4 -48.3 18.3 22.1 -9.6 80 249 A A H 3< S+ 0 0 4 -4,-2.6 -1,-0.2 1,-0.2 -2,-0.2 0.755 106.8 55.8 -62.6 -27.8 16.2 24.8 -11.3 81 250 A Q H 3< S+ 0 0 100 -4,-1.4 -1,-0.2 -3,-0.2 -2,-0.2 0.557 78.6 122.4 -85.8 -11.7 14.1 22.2 -13.2 82 251 A Q S+ 0 0 125 1,-0.2 4,-2.5 2,-0.2 5,-0.2 0.892 106.1 57.6 -57.1 -42.6 9.2 20.1 -9.6 84 253 A V H > S+ 0 0 36 1,-0.2 4,-1.0 2,-0.2 -1,-0.2 0.847 107.0 48.3 -60.3 -35.1 9.6 20.9 -5.9 85 254 A L H > S+ 0 0 2 -3,-0.3 4,-1.7 -6,-0.2 3,-0.4 0.908 109.8 51.6 -69.1 -43.5 11.3 24.2 -6.9 86 255 A K H < S+ 0 0 118 -4,-2.1 -2,-0.2 1,-0.2 -1,-0.2 0.905 112.5 46.8 -60.9 -37.0 8.5 25.0 -9.4 87 256 A K H < S+ 0 0 139 -4,-2.5 -1,-0.2 1,-0.2 -2,-0.2 0.723 117.2 43.5 -74.0 -23.9 6.0 24.4 -6.6 88 257 A S H >< S+ 0 0 16 -4,-1.0 3,-2.1 -3,-0.4 117,-0.4 0.588 81.8 120.2 -97.5 -15.2 8.0 26.5 -4.1 89 258 A Y T 3< S+ 0 0 76 -4,-1.7 117,-0.2 1,-0.3 3,-0.1 -0.317 88.5 1.7 -65.5 130.3 8.9 29.5 -6.3 90 259 A S T 3 S+ 0 0 81 115,-2.9 -1,-0.3 1,-0.3 2,-0.2 0.432 101.9 132.4 73.5 4.2 7.5 32.8 -4.9 91 260 A K < - 0 0 115 -3,-2.1 114,-2.2 114,-0.2 2,-0.3 -0.562 58.5-116.3 -87.8 150.3 6.1 31.0 -1.9 92 261 A A E -D 204 0A 46 112,-0.2 2,-0.3 -2,-0.2 112,-0.2 -0.651 33.1-177.1 -86.5 139.0 6.5 32.2 1.7 93 262 A F E -D 203 0A 20 110,-3.1 110,-2.2 -2,-0.3 2,-0.5 -0.883 24.3-132.7-128.9 160.1 8.4 30.1 4.2 94 263 A T E -D 202 0A 81 -2,-0.3 2,-0.3 108,-0.2 108,-0.2 -0.974 25.6-162.4-116.3 112.4 9.2 30.4 7.9 95 264 A L E -D 201 0A 0 106,-2.6 106,-2.5 -2,-0.5 2,-0.5 -0.782 10.5-136.0 -97.5 144.7 12.9 29.8 8.7 96 265 A T E -DE 200 112A 33 16,-0.6 16,-2.7 -2,-0.3 2,-0.5 -0.868 11.6-163.0-103.5 126.5 14.2 29.0 12.1 97 266 A I E +DE 199 111A 0 102,-3.2 102,-2.3 -2,-0.5 14,-0.2 -0.953 12.7 173.0-107.2 125.1 17.4 30.6 13.4 98 267 A S E + 0 0 12 12,-1.7 97,-2.2 -2,-0.5 2,-0.3 0.511 60.5 10.3-109.4 -12.7 18.9 28.8 16.4 99 268 A A E -DE 194 110A 4 11,-0.8 11,-2.7 95,-0.2 2,-0.3 -0.989 53.9-140.8-162.9 154.4 22.2 30.6 16.9 100 269 A L E -DE 193 109A 0 93,-2.2 93,-2.9 -2,-0.3 2,-0.3 -0.880 25.9-166.1-114.0 154.5 24.4 33.6 15.9 101 270 A F E -DE 192 108A 2 7,-2.3 7,-1.8 -2,-0.3 2,-0.4 -0.982 13.7-161.1-144.6 154.9 28.1 33.3 15.4 102 271 A V E +DE 191 107A 0 89,-2.3 89,-2.6 -2,-0.3 5,-0.2 -0.988 14.3 165.5-132.0 135.2 31.2 35.4 15.1 103 272 A T - 0 0 3 3,-2.4 87,-0.2 -2,-0.4 86,-0.1 -0.873 55.4 -95.1-131.5 173.8 34.6 34.5 13.7 104 273 A P S S+ 0 0 35 0, 0.0 3,-0.1 0, 0.0 85,-0.1 0.656 125.5 38.3 -62.1 -13.2 37.5 36.8 12.6 105 274 A K S S+ 0 0 103 1,-0.3 42,-2.7 41,-0.1 2,-0.3 0.792 122.6 3.0-104.9 -38.4 36.1 36.6 9.1 106 275 A T E - F 0 146A 0 40,-0.2 -3,-2.4 48,-0.1 2,-0.3 -0.929 45.7-150.4-147.7 164.0 32.3 36.7 9.3 107 276 A T E +EF 102 145A 1 38,-2.3 37,-2.7 -2,-0.3 38,-1.6 -0.995 35.6 129.2-136.4 141.8 29.2 36.9 11.4 108 277 A G E -EF 101 143A 0 -7,-1.8 -7,-2.3 -2,-0.3 2,-0.4 -0.960 48.4 -81.8-168.3-170.1 25.9 35.4 10.7 109 278 A A E -EF 100 142A 0 33,-2.4 33,-2.0 -2,-0.3 2,-0.6 -0.901 31.0-129.0-115.1 136.8 22.9 33.3 11.8 110 279 A R E -EF 99 141A 63 -11,-2.7 -12,-1.7 -2,-0.4 -11,-0.8 -0.770 23.7-155.1 -82.4 122.5 22.6 29.5 11.8 111 280 A V E -E 97 0A 3 29,-2.0 2,-0.7 -2,-0.6 -14,-0.2 -0.843 4.3-156.7 -98.4 133.8 19.4 28.4 10.0 112 281 A E E -E 96 0A 83 -16,-2.7 -16,-0.6 -2,-0.4 2,-0.1 -0.917 19.3-149.1-111.9 102.6 17.9 25.0 10.9 113 282 A L - 0 0 26 -2,-0.7 -18,-0.1 24,-0.3 2,-0.1 -0.415 8.0-124.9 -75.6 145.8 15.8 23.8 8.0 114 283 A S > - 0 0 48 -2,-0.1 4,-2.1 1,-0.1 5,-0.1 -0.297 32.3-101.5 -77.6 167.8 12.7 21.7 8.3 115 284 A E T 4 S+ 0 0 166 1,-0.2 4,-0.4 2,-0.2 -1,-0.1 0.907 125.3 49.4 -57.9 -42.4 12.3 18.4 6.4 116 285 A Q T >4 S+ 0 0 123 1,-0.2 3,-1.4 2,-0.2 4,-0.2 0.919 110.5 48.9 -62.1 -47.8 10.1 20.2 3.9 117 286 A Q G >4 S+ 0 0 12 1,-0.3 3,-1.9 2,-0.2 -1,-0.2 0.818 100.3 66.4 -64.2 -30.5 12.6 23.0 3.4 118 287 A L G >< S+ 0 0 36 -4,-2.1 3,-1.2 1,-0.3 -1,-0.3 0.662 83.1 74.9 -66.4 -16.2 15.4 20.4 2.9 119 288 A Q G < S+ 0 0 99 -3,-1.4 -1,-0.3 -4,-0.4 -2,-0.2 0.739 98.8 46.7 -63.1 -23.7 13.7 19.4 -0.3 120 289 A L G < S+ 0 0 1 -3,-1.9 -1,-0.2 -4,-0.2 -2,-0.2 0.335 90.6 105.3 -97.3 2.6 15.1 22.6 -1.7 121 290 A W < - 0 0 8 -3,-1.2 -56,-0.1 -4,-0.1 -55,-0.1 -0.725 68.3-130.7 -87.5 128.2 18.6 22.0 -0.3 122 291 A P - 0 0 7 0, 0.0 3,-0.5 0, 0.0 15,-0.2 -0.302 17.6-108.3 -76.2 161.6 21.2 20.9 -2.8 123 292 A S S S+ 0 0 77 1,-0.2 13,-0.0 2,-0.1 0, 0.0 -0.454 92.7 27.5 -77.8 158.3 23.6 18.0 -2.7 124 293 A D S S+ 0 0 126 -2,-0.1 -1,-0.2 1,-0.1 0, 0.0 0.784 89.4 98.5 62.4 33.7 27.4 18.4 -2.1 125 294 A V + 0 0 26 -3,-0.5 -2,-0.1 1,-0.0 -1,-0.1 0.482 66.6 68.3-117.2 -10.6 27.3 21.7 -0.2 126 295 A D S S+ 0 0 15 -4,-0.1 8,-0.4 8,-0.1 2,-0.4 0.159 83.7 90.6 -98.4 20.9 27.6 20.4 3.4 127 296 A K + 0 0 84 1,-0.1 33,-0.1 6,-0.1 4,-0.0 -0.919 40.2 177.7-120.1 139.0 31.2 19.1 3.2 128 297 A L S S+ 0 0 58 -2,-0.4 -1,-0.1 1,-0.3 33,-0.0 0.609 87.9 19.3-100.2 -27.2 34.6 20.6 3.8 129 298 A S S > S- 0 0 32 1,-0.0 3,-1.8 0, 0.0 -1,-0.3 -0.947 88.4-105.1-134.6 161.7 36.3 17.4 3.0 130 299 A P T 3 S+ 0 0 122 0, 0.0 -1,-0.0 0, 0.0 0, 0.0 0.820 117.8 49.9 -52.0 -38.0 35.2 14.2 1.1 131 300 A T T 3 S+ 0 0 124 2,-0.0 2,-0.0 -3,-0.0 -4,-0.0 0.365 81.0 125.3 -90.0 3.7 34.8 12.1 4.2 132 301 A D < - 0 0 30 -3,-1.8 -6,-0.1 1,-0.1 -5,-0.0 -0.352 36.8-173.4 -64.3 143.4 32.6 14.7 6.1 133 302 A N + 0 0 127 -2,-0.0 -1,-0.1 31,-0.0 -6,-0.1 -0.336 23.8 150.4-136.4 49.8 29.2 13.4 7.4 134 303 A L - 0 0 20 -8,-0.4 3,-0.1 1,-0.1 4,-0.1 -0.556 58.0 -84.6 -75.2 148.4 27.5 16.5 8.8 135 304 A P > - 0 0 88 0, 0.0 3,-1.9 0, 0.0 -1,-0.1 -0.176 52.8 -90.9 -51.5 143.1 23.6 16.5 8.6 136 305 A R T 3 S+ 0 0 121 1,-0.3 -13,-0.1 2,-0.1 -18,-0.1 -0.362 116.6 27.6 -49.0 131.9 22.0 17.6 5.3 137 306 A G T > S+ 0 0 8 -15,-0.2 3,-1.7 -3,-0.1 -24,-0.3 0.431 78.0 130.4 90.6 0.2 21.4 21.4 5.6 138 307 A S T < + 0 0 8 -3,-1.9 -27,-0.1 1,-0.3 -2,-0.1 0.808 69.6 55.7 -59.1 -32.9 24.3 22.1 8.0 139 308 A R T 3 S+ 0 0 53 -29,-0.1 -1,-0.3 20,-0.1 20,-0.1 0.642 76.0 126.2 -74.1 -14.2 25.6 25.0 5.9 140 309 A A < + 0 0 0 -3,-1.7 -29,-2.0 -29,-0.1 2,-0.3 -0.209 36.8 138.9 -56.7 123.3 22.3 26.8 5.9 141 310 A H E - F 0 110A 22 -77,-0.3 2,-0.4 -31,-0.2 -77,-0.4 -0.961 51.0-126.5-156.2 167.2 22.9 30.3 7.2 142 311 A I E - F 0 109A 0 -33,-2.0 -33,-2.4 -2,-0.3 2,-0.3 -0.988 30.0-134.1-124.2 119.3 22.2 34.0 6.8 143 312 A T E + F 0 108A 21 -81,-0.6 -81,-0.3 -2,-0.4 -35,-0.3 -0.576 26.6 173.3 -73.2 133.9 25.2 36.3 6.5 144 313 A L E - 0 0 18 -37,-2.7 2,-0.3 1,-0.4 -36,-0.2 0.558 62.7 -18.1-114.7 -17.2 25.1 39.4 8.7 145 314 A G E - F 0 107A 0 -38,-1.6 -38,-2.3 -89,-0.2 -1,-0.4 -0.905 50.6-149.2 176.2 157.7 28.6 40.8 8.0 146 315 A C E -CF 55 106A 6 -91,-2.2 -91,-2.0 -2,-0.3 -40,-0.2 -0.978 28.6-108.2-136.6 145.1 32.1 40.2 6.7 147 316 A A > - 0 0 5 -42,-2.7 3,-2.0 -2,-0.3 -94,-0.1 -0.315 50.7 -94.6 -63.4 161.0 35.6 41.6 7.5 148 317 A A T 3 S+ 0 0 82 -96,-0.4 -1,-0.1 1,-0.3 -43,-0.0 0.811 121.5 37.3 -55.2 -42.3 37.0 43.9 4.8 149 318 A D T 3 S+ 0 0 146 2,-0.1 2,-0.4 -44,-0.0 -1,-0.3 0.188 97.4 104.6 -95.9 15.3 39.0 41.3 2.8 150 319 A V < - 0 0 10 -3,-2.0 2,-0.2 -45,-0.1 -4,-0.0 -0.831 64.1-135.2-109.7 134.4 36.5 38.4 3.2 151 320 A E > - 0 0 149 -2,-0.4 3,-2.0 1,-0.1 4,-0.2 -0.606 24.3-121.3 -82.7 144.7 34.0 37.1 0.6 152 321 A A T > S+ 0 0 57 1,-0.3 3,-1.9 -2,-0.2 4,-0.4 0.784 107.2 71.6 -61.2 -28.6 30.5 36.4 1.8 153 322 A V T >> S+ 0 0 79 1,-0.3 4,-1.1 2,-0.2 3,-0.7 0.769 83.0 74.0 -56.7 -23.7 30.7 32.7 0.8 154 323 A Q H <> S+ 0 0 41 -3,-2.0 4,-2.8 1,-0.2 -1,-0.3 0.753 80.0 72.4 -61.6 -25.1 33.1 32.3 3.8 155 324 A T H <> S+ 0 0 0 -3,-1.9 4,-1.8 -4,-0.2 -1,-0.2 0.918 99.0 44.6 -59.4 -44.5 30.1 32.6 6.2 156 325 A G H <> S+ 0 0 0 -3,-0.7 4,-2.4 -4,-0.4 -1,-0.2 0.872 112.7 51.5 -67.4 -38.2 28.8 29.2 5.3 157 326 A L H X S+ 0 0 45 -4,-1.1 4,-2.2 2,-0.2 -2,-0.2 0.897 108.3 52.2 -65.7 -38.6 32.3 27.7 5.5 158 327 A D H X S+ 0 0 6 -4,-2.8 4,-2.2 2,-0.2 -2,-0.2 0.898 110.0 48.9 -62.8 -40.9 32.8 29.2 8.9 159 328 A L H X S+ 0 0 3 -4,-1.8 4,-2.8 2,-0.2 5,-0.2 0.924 110.2 50.6 -66.3 -43.6 29.5 27.6 10.1 160 329 A L H X S+ 0 0 0 -4,-2.4 4,-2.3 1,-0.2 -2,-0.2 0.890 109.8 51.1 -59.9 -40.0 30.5 24.2 8.7 161 330 A E H X S+ 0 0 74 -4,-2.2 4,-2.3 2,-0.2 -1,-0.2 0.910 111.1 48.0 -63.7 -43.3 33.9 24.5 10.5 162 331 A I H X S+ 0 0 0 -4,-2.2 4,-2.1 2,-0.2 -2,-0.2 0.942 113.9 46.1 -61.2 -47.5 32.0 25.3 13.8 163 332 A L H X S+ 0 0 16 -4,-2.8 4,-2.2 1,-0.2 -2,-0.2 0.841 112.3 51.6 -68.6 -30.2 29.7 22.4 13.3 164 333 A R H X S+ 0 0 105 -4,-2.3 4,-2.1 -5,-0.2 -1,-0.2 0.897 107.3 53.0 -68.9 -41.4 32.6 20.1 12.4 165 334 A Q H <>S+ 0 0 34 -4,-2.3 5,-2.3 1,-0.2 4,-0.3 0.933 113.4 43.3 -60.0 -47.5 34.5 21.1 15.6 166 335 A E H ><5S+ 0 0 52 -4,-2.1 3,-1.2 1,-0.2 -1,-0.2 0.887 112.5 51.2 -67.2 -41.2 31.4 20.2 17.7 167 336 A K H 3<5S+ 0 0 132 -4,-2.2 -1,-0.2 1,-0.3 -2,-0.2 0.846 106.7 57.0 -64.8 -31.2 30.7 17.0 15.8 168 337 A G T 3<5S- 0 0 71 -4,-2.1 -1,-0.3 -5,-0.1 -2,-0.2 0.515 127.6 -97.4 -78.1 -8.2 34.3 16.0 16.3 169 338 A G T < 5S+ 0 0 44 -3,-1.2 2,-0.7 -4,-0.3 -3,-0.2 0.464 93.2 110.5 108.5 5.4 34.0 16.3 20.1 170 339 A S < + 0 0 66 -5,-2.3 -3,-0.1 -6,-0.2 -2,-0.1 -0.702 45.7 174.8-111.6 77.2 35.4 19.8 20.8 171 340 A R - 0 0 177 -2,-0.7 14,-0.1 -5,-0.2 -8,-0.0 -0.387 35.5 -86.0 -83.8 162.5 32.3 21.9 21.8 172 341 A G - 0 0 11 -2,-0.1 2,-0.5 1,-0.1 14,-0.2 -0.239 35.2-119.9 -67.0 151.3 32.3 25.4 23.0 173 342 A E E -G 185 0A 135 12,-2.4 12,-2.7 2,-0.0 2,-0.4 -0.818 26.3-122.4 -89.6 126.4 32.9 26.5 26.6 174 343 A E E +G 184 0A 96 -2,-0.5 10,-0.2 10,-0.2 3,-0.1 -0.568 38.3 168.2 -69.0 121.5 29.9 28.4 28.1 175 344 A V E - 0 0 41 8,-2.6 2,-0.3 -2,-0.4 9,-0.2 0.427 53.7 -53.7-117.6 -3.5 31.4 31.7 29.2 176 345 A G E -G 183 0A 7 7,-1.0 7,-2.7 -143,-0.0 2,-0.4 -0.993 56.8 -72.2 159.2-164.2 28.3 33.8 30.0 177 346 A E E +G 182 0A 141 -2,-0.3 5,-0.2 5,-0.3 2,-0.2 -0.994 33.0 178.6-134.9 129.5 24.9 35.1 28.9 178 347 A L E > -G 181 0A 24 3,-2.4 3,-1.2 -2,-0.4 2,-0.1 -0.608 53.3 -58.5-112.0-179.3 24.1 37.9 26.5 179 348 A S T 3 S+ 0 0 58 1,-0.2 -1,-0.1 -2,-0.2 -152,-0.0 -0.446 126.4 14.2 -56.8 134.0 20.7 39.2 25.3 180 349 A R T 3 S- 0 0 126 -2,-0.1 16,-3.1 15,-0.1 17,-0.6 0.128 126.9 -31.4 84.5 -18.0 18.8 36.3 23.8 181 350 A G E < S-GH 178 195A 12 -3,-1.2 -3,-2.4 14,-0.3 2,-0.3 -0.991 80.9 -28.6 172.3-160.0 21.0 33.4 25.1 182 351 A K E -GH 177 194A 92 12,-1.4 12,-2.3 -2,-0.3 2,-0.4 -0.704 45.5-137.7 -94.3 138.5 24.1 31.7 26.2 183 352 A L E -GH 176 193A 0 -7,-2.7 -8,-2.6 -2,-0.3 -7,-1.0 -0.838 18.1-166.9 -99.7 131.6 27.6 32.7 24.9 184 353 A Y E -GH 174 192A 50 8,-2.5 8,-2.2 -2,-0.4 2,-0.6 -0.962 15.0-143.1-122.2 133.9 30.1 30.0 24.0 185 354 A S E +GH 173 191A 26 -12,-2.7 -12,-2.4 -2,-0.4 6,-0.2 -0.876 17.3 178.4 -94.3 119.3 33.9 30.3 23.3 186 355 A L E - 0 0 9 4,-2.7 5,-0.2 -2,-0.6 -1,-0.1 0.461 43.7-117.3 -99.1 -4.2 34.9 28.0 20.5 187 356 A G E > S+ H 0 190A 24 3,-0.7 3,-1.2 -14,-0.1 -1,-0.2 0.085 86.6 61.4 81.6 159.0 38.6 29.2 20.5 188 357 A N T 3 S- 0 0 127 1,-0.3 3,-0.1 -3,-0.1 -147,-0.0 0.831 132.4 -49.5 57.8 39.7 40.6 30.9 17.8 189 358 A G T 3 S+ 0 0 1 1,-0.2 2,-0.4 -86,-0.1 -1,-0.3 0.517 106.0 130.5 85.4 8.3 38.4 34.0 17.5 190 359 A R E < +H 187 0A 31 -3,-1.2 -4,-2.7 -87,-0.2 -3,-0.7 -0.807 28.2 172.9-109.5 137.7 35.1 32.0 17.3 191 360 A W E -HD 185 102A 2 -89,-2.6 -89,-2.3 -2,-0.4 2,-0.4 -0.986 11.6-163.0-142.5 142.7 32.0 32.7 19.3 192 361 A M E -HD 184 101A 15 -8,-2.2 -8,-2.5 -2,-0.3 2,-0.6 -0.997 8.0-158.6-135.9 131.7 28.5 31.3 19.3 193 362 A L E -HD 183 100A 1 -93,-2.9 -93,-2.2 -2,-0.4 2,-0.5 -0.948 14.6-155.3-102.9 112.9 25.3 32.7 20.9 194 363 A T E -HD 182 99A 40 -12,-2.3 -12,-1.4 -2,-0.6 2,-0.3 -0.804 21.9-125.1 -88.5 127.9 22.7 29.9 21.2 195 364 A L E -H 181 0A 12 -97,-2.2 -14,-0.3 -2,-0.5 3,-0.2 -0.568 10.5-153.9 -80.7 132.2 19.2 31.4 21.3 196 365 A A E S+ 0 0 89 -16,-3.1 2,-0.5 -2,-0.3 -1,-0.2 0.874 96.7 32.4 -66.7 -40.2 17.0 30.6 24.3 197 366 A K E S- 0 0 177 -17,-0.6 -1,-0.3 -3,-0.1 0, 0.0 -0.984 97.4-125.7-115.3 118.1 14.0 31.3 22.0 198 367 A N E - 0 0 82 -2,-0.5 2,-0.4 -3,-0.2 -100,-0.2 -0.318 24.6-123.8 -62.0 142.4 14.7 30.4 18.4 199 368 A M E - D 0 97A 11 -102,-2.3 -102,-3.2 -182,-0.0 2,-0.5 -0.769 19.7-154.6 -89.6 134.1 14.0 33.3 16.0 200 369 A E E - D 0 96A 97 -2,-0.4 2,-0.4 -104,-0.2 -104,-0.2 -0.944 12.3-172.3-109.7 130.8 11.5 32.7 13.2 201 370 A V E - D 0 95A 1 -106,-2.5 -106,-2.6 -2,-0.5 2,-0.3 -0.946 19.9-131.0-123.5 143.6 11.8 34.8 10.1 202 371 A R E + D 0 94A 137 -2,-0.4 -192,-2.0 -108,-0.2 2,-0.3 -0.746 36.2 166.7 -91.3 140.8 9.4 35.0 7.1 203 372 A A E -BD 9 93A 0 -110,-2.2 -110,-3.1 -2,-0.3 2,-0.5 -0.993 31.0-129.3-156.9 151.6 11.1 34.7 3.7 204 373 A I E -BD 8 92A 49 -196,-2.5 -196,-2.8 -2,-0.3 2,-0.6 -0.900 22.8-128.5-108.2 132.6 10.2 34.1 -0.0 205 374 A F E +B 7 0A 0 -114,-2.2 -115,-2.9 -2,-0.5 2,-0.3 -0.673 53.7 130.5 -78.9 122.1 11.9 31.5 -2.1 206 375 A T E -B 6 0A 37 -200,-2.7 -200,-2.0 -2,-0.6 2,-0.4 -0.918 54.7 -94.1-157.4 178.0 13.1 33.1 -5.3 207 376 A G E -B 5 0A 10 -2,-0.3 2,-0.5 -202,-0.2 -202,-0.2 -0.875 26.3-148.0-105.2 143.6 16.1 33.6 -7.6 208 377 A Y E -B 4 0A 95 -204,-2.9 -205,-2.2 -2,-0.4 -204,-1.5 -0.946 8.9-171.3-112.8 128.7 18.6 36.5 -7.4 209 378 A Y 0 0 133 -2,-0.5 -1,-0.1 1,-0.4 -204,-0.0 0.302 360.0 360.0-106.1 7.2 20.1 37.7 -10.7 210 379 A G 0 0 67 -206,-0.1 -1,-0.4 0, 0.0 -206,-0.0 -0.377 360.0 360.0 100.1 360.0 22.7 40.2 -9.4