==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=20-DEC-2009 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER LYASE 17-JAN-05 1YK9 . COMPND 2 MOLECULE: ADENYLATE CYCLASE; . SOURCE 2 ORGANISM_SCIENTIFIC: MYCOBACTERIUM TUBERCULOSIS; . AUTHOR A.D.KETKAR,A.R.SHENOY,U.A.RAMAGOPAL,S.S.VISWESWARIAH, . 184 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 11837.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 100 54.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 3 1.6 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 29 15.8 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 20 10.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 13 7.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 26 14.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 2 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 1 1 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 245 A D 0 0 152 0, 0.0 2,-0.3 0, 0.0 108,-0.1 0.000 360.0 360.0 360.0 135.9 2.7 -11.2 -17.2 2 246 A K - 0 0 93 1,-0.1 108,-0.7 106,-0.1 0, 0.0 -0.850 360.0-172.0-125.2 161.9 6.1 -12.5 -16.2 3 247 A Y + 0 0 152 -2,-0.3 105,-1.2 106,-0.2 -1,-0.1 0.760 44.9 112.4-110.8 -73.4 8.8 -11.5 -13.6 4 248 A D S S- 0 0 85 103,-0.1 2,-0.3 1,-0.1 104,-0.1 0.088 79.9 -58.1 30.4-123.9 12.1 -13.4 -14.0 5 249 A E + 0 0 84 102,-0.2 2,-0.3 2,-0.0 -1,-0.1 -0.989 54.2 166.3-152.1 141.2 14.9 -11.1 -15.1 6 250 A A E -A 106 0A 5 100,-2.9 100,-2.4 -2,-0.3 2,-0.3 -0.983 29.5-117.9-151.9 158.9 15.6 -8.8 -18.0 7 251 A S E -A 105 0A 1 -2,-0.3 55,-2.8 98,-0.2 56,-0.4 -0.767 25.5-160.4-101.8 147.3 18.0 -6.0 -19.1 8 252 A V E -AB 104 61A 0 96,-3.5 96,-1.2 -2,-0.3 2,-0.4 -0.972 5.1-151.6-131.6 142.4 16.9 -2.5 -19.9 9 253 A L E -AB 103 60A 0 51,-2.7 51,-1.0 -2,-0.4 2,-0.4 -0.918 8.7-169.1-114.9 139.7 18.5 0.4 -21.9 10 254 A F E +AB 102 59A 30 92,-2.4 92,-3.0 -2,-0.4 2,-0.3 -0.993 9.1 174.7-129.7 131.9 17.9 4.1 -21.4 11 255 A A E +AB 101 58A 0 47,-1.7 47,-2.4 -2,-0.4 2,-0.3 -0.992 7.4 155.8-140.1 145.8 19.0 6.9 -23.7 12 256 A D E -A 100 0A 23 88,-2.0 88,-1.6 -2,-0.3 2,-0.4 -0.884 28.8-134.6-168.7 136.3 18.6 10.7 -23.9 13 257 A I E -A 99 0A 19 43,-0.3 3,-0.3 -2,-0.3 86,-0.2 -0.764 2.0-161.0 -97.6 137.4 20.5 13.7 -25.4 14 258 A V S S+ 0 0 63 84,-1.1 2,-0.5 -2,-0.4 -1,-0.1 0.628 84.7 74.4 -88.4 -15.0 21.2 16.9 -23.5 15 259 A G + 0 0 18 83,-0.2 2,-0.7 3,-0.1 -1,-0.2 -0.242 61.4 121.6 -92.3 44.5 21.8 18.8 -26.8 16 260 A F S S- 0 0 39 -2,-0.5 -1,-0.1 -3,-0.3 40,-0.1 -0.722 99.8 -52.0-110.1 79.9 18.1 19.0 -27.7 17 261 A T S S+ 0 0 29 -2,-0.7 -1,-0.1 1,-0.1 -2,-0.1 0.971 119.6 93.5 52.0 64.7 17.4 22.7 -27.9 18 262 A E + 0 0 159 -4,-0.0 -3,-0.1 0, 0.0 -1,-0.1 0.358 60.7 77.8-152.6 -20.4 18.9 23.7 -24.6 19 263 A R S S- 0 0 168 1,-0.1 -4,-0.0 -5,-0.0 -3,-0.0 0.991 120.9 -54.0 -62.4 -81.9 22.5 24.6 -25.3 20 264 A A S S+ 0 0 95 0, 0.0 -1,-0.1 0, 0.0 0, 0.0 0.194 89.5 136.8-149.9 13.6 22.3 28.2 -26.7 21 265 A S - 0 0 63 1,-0.1 0, 0.0 3,-0.0 0, 0.0 -0.258 50.8-142.2 -67.3 154.1 19.9 27.8 -29.6 22 266 A S - 0 0 122 0, 0.0 -1,-0.1 0, 0.0 0, 0.0 0.645 46.6-115.0 -89.5 -18.1 17.2 30.5 -30.3 23 267 A T - 0 0 97 1,-0.1 3,-0.0 3,-0.0 0, 0.0 0.797 34.9-163.5 81.3 108.0 14.7 27.8 -31.3 24 268 A A - 0 0 43 1,-0.1 -1,-0.1 2,-0.1 -3,-0.0 -0.950 24.5-143.4-124.9 142.6 13.4 27.8 -34.9 25 269 A P S S+ 0 0 123 0, 0.0 2,-0.4 0, 0.0 -1,-0.1 0.782 89.5 62.4 -70.4 -27.7 10.3 26.1 -36.5 26 270 A A S S- 0 0 61 1,-0.1 2,-2.8 -3,-0.0 3,-0.1 -0.808 120.0 -10.2-103.5 142.6 12.3 25.4 -39.7 27 271 A D S >> S+ 0 0 109 -2,-0.4 4,-1.0 1,-0.1 3,-0.8 -0.289 113.7 90.9 71.5 -56.5 15.4 23.2 -39.9 28 272 A L T 34 S+ 0 0 44 -2,-2.8 -1,-0.1 1,-0.2 5,-0.0 -0.102 89.7 18.2 -64.4 168.6 15.7 23.0 -36.1 29 273 A V T 34 S+ 0 0 52 1,-0.2 -1,-0.2 -3,-0.1 -2,-0.1 0.756 119.2 71.8 32.6 37.0 14.0 20.2 -34.1 30 274 A R T <> S+ 0 0 169 -3,-0.8 4,-0.5 -4,-0.1 -2,-0.2 0.449 89.0 50.5-141.2 -29.9 13.8 18.3 -37.4 31 275 A F H X S+ 0 0 83 -4,-1.0 4,-0.6 2,-0.2 -3,-0.1 0.799 114.7 46.0 -81.0 -33.1 17.4 17.3 -38.1 32 276 A L H > S+ 0 0 32 2,-0.2 4,-1.4 1,-0.2 3,-0.3 0.831 111.7 52.0 -73.1 -35.8 17.7 15.9 -34.6 33 277 A D H > S+ 0 0 83 1,-0.2 4,-0.7 2,-0.2 -2,-0.2 0.725 104.0 58.5 -71.0 -24.0 14.3 14.2 -35.1 34 278 A R H < S+ 0 0 169 -4,-0.5 -1,-0.2 2,-0.2 -2,-0.2 0.723 102.2 54.5 -76.6 -23.7 15.7 12.7 -38.3 35 279 A L H >< S+ 0 0 31 -4,-0.6 3,-1.5 -3,-0.3 4,-0.5 0.922 107.9 47.1 -72.5 -47.4 18.5 11.1 -36.3 36 280 A Y H 3X S+ 0 0 38 -4,-1.4 4,-1.1 1,-0.3 3,-0.4 0.694 103.5 64.8 -66.9 -20.4 16.0 9.3 -34.0 37 281 A S T 3< S+ 0 0 45 -4,-0.7 4,-0.4 1,-0.2 -1,-0.3 0.604 98.9 53.7 -77.6 -12.5 14.1 8.2 -37.1 38 282 A A T <> S+ 0 0 31 -3,-1.5 4,-0.9 -4,-0.2 -1,-0.2 0.579 101.5 59.8 -93.6 -14.9 17.1 6.2 -38.2 39 283 A F T 4 S+ 0 0 11 -4,-0.5 -2,-0.2 -3,-0.4 -3,-0.1 0.859 103.2 48.5 -79.9 -39.4 17.2 4.4 -34.8 40 284 A D T >< S+ 0 0 82 -4,-1.1 3,-0.5 1,-0.2 4,-0.4 0.792 110.7 52.4 -70.8 -29.6 13.7 2.9 -35.1 41 285 A E G >4 S+ 0 0 143 -4,-0.4 3,-0.5 1,-0.2 -1,-0.2 0.821 108.7 49.9 -73.0 -33.2 14.5 1.7 -38.7 42 286 A L G 3< S+ 0 0 94 -4,-0.9 -1,-0.2 1,-0.2 -2,-0.2 0.367 85.8 93.4 -86.5 3.5 17.7 -0.0 -37.4 43 287 A V G X + 0 0 15 -3,-0.5 2,-1.2 1,-0.1 3,-0.9 0.906 57.4 93.7 -60.8 -44.5 15.6 -1.7 -34.7 44 288 A D T < + 0 0 145 -3,-0.5 -1,-0.1 -4,-0.4 3,-0.1 -0.326 60.9 84.6 -57.0 91.5 15.1 -4.8 -36.8 45 289 A Q T 3 S- 0 0 105 -2,-1.2 -1,-0.2 1,-0.6 2,-0.2 0.298 95.6 -12.8-154.6 -48.4 18.0 -6.9 -35.6 46 290 A H S < S- 0 0 111 -3,-0.9 2,-1.6 2,-0.1 -1,-0.6 -0.643 98.9 -44.2-143.3-160.0 17.0 -8.8 -32.4 47 291 A G S S+ 0 0 28 -2,-0.2 17,-0.4 -3,-0.1 2,-0.3 -0.597 83.7 129.3 -81.9 83.1 14.2 -8.9 -29.7 48 292 A L + 0 0 13 -2,-1.6 2,-0.3 -5,-0.1 14,-0.1 -1.000 26.3 169.5-141.4 139.2 13.8 -5.1 -29.1 49 293 A E E -C 61 0A 117 12,-0.8 12,-1.0 -2,-0.3 2,-0.3 -0.997 35.8-109.0-150.0 145.7 10.8 -2.8 -28.9 50 294 A K E +C 60 0A 85 -2,-0.3 10,-0.2 10,-0.2 3,-0.1 -0.543 40.4 165.8 -73.8 134.3 10.1 0.8 -27.9 51 295 A I + 0 0 18 8,-1.1 2,-0.3 1,-0.4 70,-0.2 0.682 50.2 18.7-112.7 -88.1 8.0 1.0 -24.7 52 296 A E + 0 0 69 7,-0.2 7,-0.6 68,-0.1 -1,-0.4 -0.681 54.8 163.9 -97.7 146.2 7.5 4.3 -22.8 53 297 A V + 0 0 64 -2,-0.3 5,-0.1 5,-0.1 -3,-0.0 -0.776 12.5 172.5-163.4 113.5 8.2 7.8 -24.1 54 298 A S S S- 0 0 127 -2,-0.2 -1,-0.1 0, 0.0 4,-0.0 0.906 75.6 -33.2 -86.9 -49.2 7.1 11.1 -22.5 55 299 A G S S- 0 0 53 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.223 119.4 -15.7-135.0-101.1 8.9 13.7 -24.7 56 300 A D S S+ 0 0 74 -43,-0.1 -43,-0.3 -40,-0.1 2,-0.1 0.272 97.3 118.7-100.7 8.4 12.3 13.4 -26.3 57 301 A S - 0 0 20 -45,-0.1 2,-0.4 2,-0.0 -45,-0.2 -0.470 45.3-162.8 -77.5 147.4 13.4 10.4 -24.2 58 302 A Y E +B 11 0A 7 -47,-2.4 -47,-1.7 -2,-0.1 2,-0.4 -0.937 16.2 163.3-136.8 111.9 14.3 7.0 -25.9 59 303 A M E -B 10 0A 8 -7,-0.6 -8,-1.1 -2,-0.4 2,-0.4 -0.994 13.9-168.0-133.6 134.3 14.4 3.8 -23.9 60 304 A V E -BC 9 50A 1 -51,-1.0 -51,-2.7 -2,-0.4 2,-0.3 -0.977 7.8-153.8-124.6 131.1 14.4 0.2 -25.1 61 305 A V E -BC 8 49A 14 -12,-1.0 -12,-0.8 -2,-0.4 -53,-0.2 -0.734 13.6-153.5-101.7 150.8 13.9 -3.0 -22.9 62 306 A S S S+ 0 0 14 -55,-2.8 2,-0.3 -2,-0.3 6,-0.3 0.381 76.1 97.3 -98.6 0.5 15.1 -6.5 -23.7 63 307 A G + 0 0 32 -56,-0.4 -1,-0.2 4,-0.1 -15,-0.1 -0.024 55.4 157.4 -80.9 32.4 12.3 -8.0 -21.6 64 308 A V - 0 0 29 -17,-0.4 -17,-0.1 -2,-0.3 -2,-0.0 -0.187 62.9 -93.2 -56.1 151.5 10.3 -8.6 -24.8 65 309 A P S S+ 0 0 106 0, 0.0 -1,-0.1 0, 0.0 -2,-0.0 0.767 121.4 56.3 -32.9 -46.0 7.6 -11.3 -24.7 66 310 A R S S- 0 0 49 2,-0.0 2,-0.3 0, 0.0 -2,-0.2 -0.840 83.9-160.9 -97.6 102.6 10.2 -13.8 -26.0 67 311 A P - 0 0 75 0, 0.0 -4,-0.1 0, 0.0 -61,-0.0 -0.612 4.3-158.6 -89.5 142.5 13.2 -13.8 -23.7 68 312 A R > - 0 0 149 -6,-0.3 3,-0.8 -2,-0.3 6,-0.1 -0.892 27.0-121.7-117.1 148.9 16.7 -15.1 -24.7 69 313 A P T 3 S+ 0 0 115 0, 0.0 2,-0.9 0, 0.0 3,-0.4 0.874 112.0 55.2 -52.7 -41.7 19.5 -16.2 -22.3 70 314 A D T 3> + 0 0 78 1,-0.2 4,-0.6 2,-0.1 81,-0.0 -0.332 66.4 130.0 -91.5 53.1 21.8 -13.6 -23.8 71 315 A H H <> S+ 0 0 11 -2,-0.9 4,-0.6 -3,-0.8 -1,-0.2 0.788 73.1 51.6 -74.3 -28.9 19.5 -10.7 -23.1 72 316 A T H > S+ 0 0 5 -3,-0.4 4,-0.9 1,-0.2 -1,-0.2 0.792 110.2 48.8 -76.1 -30.7 22.3 -8.7 -21.5 73 317 A Q H > S+ 0 0 25 1,-0.2 4,-1.0 2,-0.2 -1,-0.2 0.581 100.6 66.8 -84.4 -12.3 24.6 -9.2 -24.5 74 318 A A H < S+ 0 0 23 -4,-0.6 4,-0.4 2,-0.2 -1,-0.2 0.786 110.3 34.0 -78.3 -29.5 21.8 -8.1 -26.9 75 319 A L H X S+ 0 0 5 -4,-0.6 4,-1.7 -3,-0.2 -2,-0.2 0.667 108.0 69.2 -94.4 -23.0 21.9 -4.6 -25.6 76 320 A A H < S+ 0 0 17 -4,-0.9 -2,-0.2 1,-0.2 4,-0.1 0.848 109.6 34.2 -64.5 -37.6 25.6 -4.6 -24.9 77 321 A D T >X S+ 0 0 33 -4,-1.0 4,-0.6 2,-0.2 3,-0.5 0.706 114.0 60.6 -87.5 -24.6 26.4 -4.7 -28.7 78 322 A F H 3> S+ 0 0 14 -4,-0.4 4,-0.6 1,-0.2 3,-0.3 0.759 98.6 57.3 -72.2 -27.5 23.3 -2.5 -29.5 79 323 A A H 3< S+ 0 0 2 -4,-1.7 4,-0.5 1,-0.2 -1,-0.2 0.629 97.5 63.5 -78.3 -14.8 24.8 0.3 -27.3 80 324 A L H <> S+ 0 0 40 -3,-0.5 4,-1.0 1,-0.2 -1,-0.2 0.758 104.4 45.3 -78.8 -27.2 27.9 0.3 -29.5 81 325 A D H X S+ 0 0 70 -4,-0.6 4,-2.4 -3,-0.3 5,-0.4 0.608 96.0 76.1 -89.7 -15.0 25.8 1.3 -32.6 82 326 A M H X S+ 0 0 1 -4,-0.6 4,-0.5 1,-0.2 -1,-0.2 0.827 110.3 28.3 -63.3 -32.2 24.0 4.0 -30.7 83 327 A T H 4 S+ 0 0 51 -4,-0.5 -2,-0.2 -3,-0.2 -1,-0.2 0.761 118.7 57.3 -96.9 -34.0 27.1 6.2 -30.9 84 328 A N H >< S+ 0 0 100 -4,-1.0 3,-0.5 1,-0.2 4,-0.3 0.930 111.4 41.3 -63.8 -48.1 28.5 4.8 -34.1 85 329 A V H >X S+ 0 0 40 -4,-2.4 2,-2.1 1,-0.3 3,-1.4 0.935 108.8 59.9 -65.9 -48.3 25.4 5.6 -36.2 86 330 A A T 3< S+ 0 0 18 -4,-0.5 -1,-0.3 -5,-0.4 13,-0.1 -0.235 98.9 62.8 -77.5 50.4 24.9 9.0 -34.5 87 331 A A T <4 S+ 0 0 44 -2,-2.1 -1,-0.2 -3,-0.5 -2,-0.2 0.425 84.7 67.1-143.3 -23.1 28.3 10.1 -35.8 88 332 A Q T <4 S+ 0 0 157 -3,-1.4 2,-1.0 -4,-0.3 3,-0.4 0.846 84.7 78.8 -73.8 -36.5 28.0 10.0 -39.6 89 333 A L < + 0 0 99 -4,-0.6 6,-0.1 1,-0.2 -1,-0.1 -0.660 51.4 116.8 -80.4 103.5 25.5 12.8 -39.8 90 334 A K + 0 0 104 -2,-1.0 5,-0.3 1,-0.4 -1,-0.2 0.547 45.2 101.5-132.6 -41.0 27.5 16.1 -39.4 91 335 A D S S+ 0 0 151 -3,-0.4 -1,-0.4 3,-0.1 2,-0.1 -0.881 72.7 33.2-104.5 133.0 27.1 18.0 -42.7 92 336 A P S S+ 0 0 72 0, 0.0 3,-0.1 0, 0.0 0, 0.0 0.581 127.1 14.0 -85.1-177.3 25.3 20.2 -43.0 93 337 A R S S- 0 0 197 -2,-0.1 2,-0.6 1,-0.1 0, 0.0 0.899 87.6-112.5 56.6 106.5 25.1 22.1 -39.7 94 338 A G + 0 0 78 -3,-0.1 -1,-0.1 1,-0.0 -3,-0.1 -0.559 44.8 169.9 -74.6 110.2 27.9 21.1 -37.3 95 339 A N - 0 0 52 -2,-0.6 -80,-0.0 -5,-0.3 -4,-0.0 -0.981 23.4-137.6-126.4 132.0 26.5 19.3 -34.3 96 340 A P - 0 0 96 0, 0.0 -81,-0.0 0, 0.0 -1,-0.0 -0.003 23.2-111.4 -72.1-176.3 28.4 17.4 -31.6 97 341 A V + 0 0 61 1,-0.1 -11,-0.0 2,-0.1 -10,-0.0 -0.709 45.7 155.4-123.5 79.0 27.5 14.1 -30.0 98 342 A P + 0 0 18 0, 0.0 -84,-1.1 0, 0.0 2,-0.3 -0.147 24.2 150.7 -93.8 38.3 26.5 14.7 -26.4 99 343 A L E -A 13 0A 11 41,-0.2 2,-0.5 -86,-0.2 -86,-0.2 -0.542 32.5-153.7 -74.9 131.5 24.3 11.5 -26.3 100 344 A R E -A 12 0A 27 -88,-1.6 -88,-2.0 -2,-0.3 2,-0.4 -0.935 11.6-173.7-113.1 124.2 24.0 9.9 -22.9 101 345 A V E -Ad 11 142A 0 40,-1.0 42,-3.2 -2,-0.5 2,-0.4 -0.954 2.4-173.8-120.9 133.7 23.4 6.2 -22.5 102 346 A G E -Ad 10 143A 0 -92,-3.0 -92,-2.4 -2,-0.4 2,-0.2 -0.989 5.0-162.2-129.4 135.1 22.7 4.2 -19.3 103 347 A L E +A 9 0A 7 40,-3.0 2,-0.3 -2,-0.4 -94,-0.2 -0.715 14.6 158.7-113.3 164.1 22.3 0.4 -18.8 104 348 A A E -A 8 0A 1 -96,-1.2 -96,-3.5 -2,-0.2 2,-0.3 -0.909 15.5-159.8-176.3 151.3 20.8 -1.8 -16.1 105 349 A T E +A 7 0A 15 -98,-0.3 -98,-0.2 -2,-0.3 42,-0.1 -0.981 35.0 89.9-141.7 153.7 19.4 -5.3 -15.5 106 350 A G E S-A 6 0A 11 -100,-2.4 -100,-2.9 -2,-0.3 2,-0.3 -0.989 72.2 -1.3 160.0-155.3 17.2 -7.0 -12.9 107 351 A P - 0 0 36 0, 0.0 19,-1.3 0, 0.0 18,-0.8 -0.490 58.1-178.5 -70.0 129.1 13.6 -7.9 -12.1 108 352 A V E -E 124 0B 14 -105,-1.2 2,-0.3 -2,-0.3 16,-0.2 -0.994 6.5-167.0-133.8 127.3 11.1 -6.5 -14.7 109 353 A V E -E 123 0B 56 14,-2.5 14,-1.8 -2,-0.4 2,-0.3 -0.880 23.3-116.5-115.5 146.4 7.3 -6.9 -14.6 110 354 A A E -E 122 0B 42 -108,-0.7 12,-0.2 -2,-0.3 11,-0.1 -0.607 20.7-161.1 -82.2 137.5 4.7 -6.2 -17.3 111 355 A G + 0 0 32 10,-0.6 10,-0.2 9,-0.6 -1,-0.1 0.956 24.9 154.6 -78.6 -85.1 2.2 -3.5 -16.7 112 356 A V - 0 0 91 8,-2.4 2,-0.5 1,-0.2 8,-0.2 0.960 28.0-159.8 46.7 90.2 -0.9 -3.8 -19.0 113 357 A V - 0 0 55 6,-1.1 6,-0.4 4,-0.2 4,-0.3 -0.876 13.8-126.9-103.2 124.1 -3.7 -2.0 -17.1 114 358 A G - 0 0 64 -2,-0.5 4,-0.1 2,-0.1 -2,-0.0 -0.484 64.7 -30.6 -71.6 134.5 -7.3 -2.8 -18.1 115 359 A S S S+ 0 0 104 -2,-0.2 2,-2.9 1,-0.2 -2,-0.0 0.181 108.2 72.8 48.3-171.6 -9.6 0.1 -18.9 116 360 A R S S+ 0 0 220 2,-0.1 2,-0.3 0, 0.0 -1,-0.2 -0.049 111.2 26.7 63.3 -39.1 -9.2 3.6 -17.4 117 361 A R S S- 0 0 38 -2,-2.9 2,-1.2 -4,-0.3 -4,-0.2 -0.934 74.0-131.3-156.9 130.2 -6.0 4.2 -19.6 118 362 A F + 0 0 214 -2,-0.3 2,-0.3 -4,-0.1 -4,-0.1 -0.670 63.3 111.1 -82.7 95.7 -4.8 2.8 -22.9 119 363 A R - 0 0 125 -2,-1.2 -6,-1.1 -6,-0.4 -2,-0.1 -0.983 47.3-166.6-164.6 151.2 -1.2 1.7 -22.1 120 364 A Y + 0 0 132 -2,-0.3 -8,-2.4 -8,-0.2 -9,-0.6 0.743 38.4 165.8-108.4 -42.4 1.1 -1.3 -21.7 121 365 A C - 0 0 28 -10,-0.2 -10,-0.6 -70,-0.2 2,-0.3 0.229 32.9-110.6 56.3-177.8 4.1 0.4 -20.1 122 366 A V E +E 110 0B 14 -12,-0.2 2,-0.3 -11,-0.1 -12,-0.2 -0.930 33.7 172.8-153.9 128.9 7.1 -1.2 -18.3 123 367 A W E +E 109 0B 184 -14,-1.8 -14,-2.5 -2,-0.3 2,-0.3 -0.940 16.3 106.5-138.1 159.9 8.0 -1.2 -14.6 124 368 A G E > S-E 108 0B 15 -2,-0.3 4,-1.0 -16,-0.2 -16,-0.2 -0.917 73.1 -73.9 158.1 179.1 10.5 -2.9 -12.2 125 369 A D H > S+ 0 0 99 -18,-0.8 4,-1.2 -2,-0.3 -17,-0.1 0.861 127.1 49.4 -69.5 -37.2 13.6 -2.4 -10.0 126 370 A A H > S+ 0 0 2 -19,-1.3 4,-0.6 1,-0.2 -1,-0.2 0.878 105.7 55.2 -69.8 -41.4 15.8 -2.3 -13.1 127 371 A V H 4 S+ 0 0 21 -20,-0.4 4,-0.3 1,-0.2 3,-0.3 0.802 107.6 51.8 -63.5 -30.1 13.7 0.2 -15.0 128 372 A N H X S+ 0 0 81 -4,-1.0 4,-0.6 1,-0.2 3,-0.5 0.843 111.7 44.3 -75.1 -36.0 14.0 2.6 -12.1 129 373 A V H < S+ 0 0 20 -4,-1.2 4,-0.4 1,-0.2 -1,-0.2 0.390 99.6 71.3 -91.6 1.9 17.8 2.4 -11.9 130 374 A A T < S+ 0 0 0 -4,-0.6 4,-0.5 -3,-0.3 -1,-0.2 0.626 95.7 53.9 -88.6 -15.2 18.3 2.7 -15.6 131 375 A S T >> S+ 0 0 35 -3,-0.5 4,-2.4 -4,-0.3 3,-0.6 0.853 98.9 57.5 -85.8 -41.5 17.3 6.4 -15.6 132 376 A R H 3X S+ 0 0 55 -4,-0.6 4,-1.9 1,-0.2 -1,-0.1 0.784 101.3 59.5 -62.6 -28.3 19.7 7.7 -12.9 133 377 A M H 34 S+ 0 0 8 -4,-0.4 -1,-0.2 2,-0.2 -2,-0.2 0.859 110.1 42.7 -65.8 -37.0 22.6 6.4 -15.0 134 378 A E H <4 S+ 0 0 21 -3,-0.6 3,-0.4 -4,-0.5 -2,-0.2 0.966 112.9 49.3 -72.3 -56.0 21.5 8.7 -17.9 135 379 A S H < S+ 0 0 74 -4,-2.4 2,-0.8 1,-0.3 -2,-0.2 0.840 114.5 47.5 -54.7 -39.0 20.7 11.8 -15.8 136 380 A T S < S+ 0 0 72 -4,-1.9 2,-0.4 -5,-0.2 -1,-0.3 -0.675 83.1 129.8-107.4 76.9 24.1 11.6 -14.1 137 381 A D - 0 0 29 -2,-0.8 -3,-0.1 -3,-0.4 5,-0.0 -0.993 41.0-148.1-133.0 137.7 26.5 11.1 -16.9 138 382 A S S > S- 0 0 66 -2,-0.4 3,-0.7 2,-0.0 2,-0.1 -0.019 70.9 -1.0 -86.7-166.7 29.8 12.9 -17.8 139 383 A V T 3 S- 0 0 119 1,-0.2 -2,-0.1 -39,-0.0 -39,-0.0 0.183 112.8 -79.8 23.2 -74.3 31.5 13.6 -21.1 140 384 A G T 3 S+ 0 0 13 -2,-0.1 -41,-0.2 -39,-0.1 -1,-0.2 0.332 86.6 123.4 151.2 49.9 28.7 11.8 -23.1 141 385 A Q < - 0 0 103 -3,-0.7 -40,-1.0 -43,-0.1 2,-0.4 -0.575 64.4 -75.3-121.7-177.8 29.4 8.1 -23.0 142 386 A I E -d 101 0A 16 36,-0.3 2,-0.6 -2,-0.2 36,-0.4 -0.693 38.3-149.9 -88.3 130.0 27.6 4.8 -21.9 143 387 A Q E -d 102 0A 9 -42,-3.2 -40,-3.0 -2,-0.4 34,-0.2 -0.883 14.1-172.2-105.2 120.6 27.3 4.1 -18.2 144 388 A V B -F 176 0C 4 32,-3.8 32,-3.7 -2,-0.6 -40,-0.1 -0.895 11.5-140.6-114.6 140.6 27.2 0.4 -17.1 145 389 A P > - 0 0 7 0, 0.0 4,-1.4 0, 0.0 30,-0.1 -0.316 31.3-100.5 -89.8 175.5 26.4 -0.9 -13.6 146 390 A D H > S+ 0 0 39 28,-0.3 4,-1.2 1,-0.2 5,-0.1 0.845 119.0 61.7 -63.7 -35.5 28.0 -3.8 -11.7 147 391 A E H >> S+ 0 0 104 1,-0.2 3,-0.9 2,-0.2 4,-0.6 0.947 109.7 38.9 -55.5 -53.4 25.1 -6.1 -12.5 148 392 A V H 34 S+ 0 0 14 1,-0.2 3,-0.4 2,-0.2 -1,-0.2 0.757 108.4 66.2 -67.2 -26.4 25.8 -5.8 -16.3 149 393 A Y H 3< S+ 0 0 81 -4,-1.4 -1,-0.2 1,-0.2 -2,-0.2 0.740 98.1 52.6 -67.7 -24.6 29.5 -6.0 -15.5 150 394 A E H << S+ 0 0 138 -4,-1.2 2,-0.9 -3,-0.9 3,-0.4 0.704 100.4 66.8 -83.2 -21.2 29.0 -9.5 -14.2 151 395 A R < + 0 0 141 -4,-0.6 -1,-0.2 -3,-0.4 -4,-0.0 -0.743 68.7 96.9-102.6 84.0 27.3 -10.5 -17.5 152 396 A L > - 0 0 35 -2,-0.9 3,-0.8 -3,-0.1 -1,-0.2 0.493 63.8-150.7-138.7 -25.7 30.1 -10.2 -20.1 153 397 A K T 3 - 0 0 141 -3,-0.4 -2,-0.1 1,-0.2 -3,-0.1 0.872 69.4 -64.3 48.0 48.0 31.4 -13.8 -20.5 154 398 A D T 3 S+ 0 0 145 1,-0.1 -1,-0.2 2,-0.1 3,-0.1 0.876 120.1 102.2 44.4 50.8 34.9 -12.5 -21.4 155 399 A D < + 0 0 73 -3,-0.8 27,-2.3 1,-0.1 2,-0.3 0.277 66.2 63.7-139.7 5.1 33.6 -10.8 -24.6 156 400 A F E -G 181 0C 21 25,-0.3 2,-0.6 2,-0.0 25,-0.2 -0.987 67.9-133.0-138.9 146.3 33.4 -7.2 -23.7 157 401 A V E + 0 0 68 23,-1.9 22,-2.1 -2,-0.3 2,-0.4 -0.877 28.5 179.4-101.1 119.8 35.8 -4.4 -22.6 158 402 A L E -G 178 0C 37 -2,-0.6 2,-0.4 20,-0.2 20,-0.2 -0.956 12.9-156.0-123.6 140.5 34.8 -2.4 -19.6 159 403 A R E -G 177 0C 184 18,-1.9 18,-1.3 -2,-0.4 2,-0.1 -0.952 23.8-114.8-119.2 133.9 36.6 0.5 -17.9 160 404 A E E +G 176 0C 132 -2,-0.4 16,-0.2 16,-0.2 14,-0.0 -0.352 31.7 173.3 -67.7 139.8 36.2 1.6 -14.3 161 405 A R - 0 0 96 14,-2.7 2,-0.3 1,-0.2 -1,-0.1 0.767 27.9-140.3-107.7 -71.0 34.7 5.0 -13.5 162 406 A G - 0 0 13 13,-0.5 13,-1.0 11,-0.1 2,-0.3 -0.999 29.3 -40.5 145.2-145.2 34.1 5.5 -9.8 163 407 A H + 0 0 103 -2,-0.3 2,-0.1 11,-0.1 11,-0.1 -0.925 42.3 166.0-127.7 149.2 31.5 6.9 -7.5 164 408 A I - 0 0 69 -2,-0.3 2,-0.4 9,-0.2 8,-0.2 -0.138 46.5 -58.7-127.0-135.7 29.3 10.1 -7.4 165 409 A N + 0 0 150 -2,-0.1 2,-0.3 6,-0.1 6,-0.1 -0.991 47.4 176.1-128.8 128.0 26.2 11.3 -5.4 166 410 A V - 0 0 40 -2,-0.4 6,-0.1 4,-0.3 0, 0.0 -0.920 22.3-175.3-129.3 153.7 22.9 9.5 -5.2 167 411 A K S S+ 0 0 214 -2,-0.3 -1,-0.1 2,-0.1 4,-0.0 0.645 86.1 50.2-113.8 -30.6 19.6 10.1 -3.3 168 412 A G S S+ 0 0 59 1,-0.1 3,-0.1 2,-0.1 -2,-0.0 0.958 119.6 31.4 -75.1 -55.6 17.6 7.0 -4.4 169 413 A K S S- 0 0 91 1,-0.1 2,-1.1 -40,-0.0 -1,-0.1 0.862 86.0-157.5 -71.6 -37.9 20.1 4.2 -3.7 170 414 A G S S+ 0 0 60 0, 0.0 2,-0.5 0, 0.0 -4,-0.3 -0.405 72.0 66.2 89.8 -56.7 21.7 6.0 -0.8 171 415 A V S S- 0 0 104 -2,-1.1 -6,-0.1 -3,-0.1 -4,-0.1 -0.882 85.1-129.9-102.6 123.2 25.0 4.1 -1.0 172 416 A M - 0 0 44 -2,-0.5 2,-0.3 -8,-0.2 -9,-0.1 -0.308 20.9-156.9 -70.3 152.8 27.1 4.6 -4.2 173 417 A R - 0 0 122 -11,-0.1 -9,-0.2 -2,-0.0 2,-0.2 -0.928 28.3 -89.8-130.5 155.2 28.4 1.7 -6.3 174 418 A T - 0 0 38 -2,-0.3 -28,-0.3 -11,-0.1 2,-0.3 -0.415 45.4-157.5 -64.9 131.4 31.3 1.3 -8.7 175 419 A W - 0 0 24 -13,-1.0 -14,-2.7 -2,-0.2 -13,-0.5 -0.785 5.9-159.3-113.4 156.4 30.3 2.1 -12.3 176 420 A Y E -FG 144 160C 31 -32,-3.7 -32,-3.8 -2,-0.3 2,-0.4 -0.799 9.4-139.2-129.1 169.7 31.8 1.0 -15.7 177 421 A L E - G 0 159C 36 -18,-1.3 -18,-1.9 -2,-0.3 2,-0.5 -0.996 16.8-133.3-134.3 129.2 31.8 2.1 -19.3 178 422 A I E + G 0 158C 20 -2,-0.4 -36,-0.3 -36,-0.4 -20,-0.2 -0.705 26.5 171.0 -85.4 123.9 31.6 -0.2 -22.4 179 423 A G E - 0 0 55 -22,-2.1 2,-0.3 -2,-0.5 -1,-0.2 0.912 58.4 -26.8 -92.4 -68.3 34.2 0.6 -25.1 180 424 A R E - 0 0 57 -23,-0.3 -23,-1.9 0, 0.0 -1,-0.4 -0.973 62.3 -99.0-149.6 160.8 34.0 -2.2 -27.7 181 425 A K E - G 0 156C 104 -2,-0.3 2,-0.5 -25,-0.2 -25,-0.3 -0.660 37.8-118.2 -85.6 135.1 33.1 -5.9 -28.0 182 426 A V + 0 0 67 -27,-2.3 2,-0.4 -2,-0.3 -1,-0.1 -0.613 38.1 174.6 -75.2 119.3 35.9 -8.5 -28.0 183 427 A A 0 0 95 -2,-0.5 -28,-0.0 1,-0.1 -2,-0.0 -0.949 360.0 360.0-131.9 112.1 35.9 -10.3 -31.3 184 428 A A 0 0 157 -2,-0.4 -1,-0.1 0, 0.0 -2,-0.0 0.783 360.0 360.0 -85.3 360.0 38.7 -12.9 -32.1