data_15792 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; talin-F2F3 ; _BMRB_accession_number 15792 _BMRB_flat_file_name bmr15792.str _Entry_type original _Submission_date 2008-06-02 _Accession_date 2008-06-02 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Goksoy Esen . . 2 Wang Xiaoxia . . 3 Qin Jun . . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 173 "15N chemical shifts" 173 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2008-07-28 original author . stop_ _Original_release_date 2008-07-28 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title 'Structural basis for the autoinhibition of talin in regulating integrin activation' _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 18614051 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Goksoy Esen . . 2 Ma Yan-Qing . . 3 Wang Xiaoxia . . 4 Kong Xiangming . . 5 Perera Dhanuja . . 6 Plow Edward F. . 7 Qin Jun . . stop_ _Journal_abbreviation 'Mol. Cell' _Journal_volume 31 _Journal_issue 1 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 124 _Page_last 133 _Year 2008 _Details . save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name talin-F2F3 _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label talin-F2F3 $talin-F2F3 stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state ? _System_paramagnetic no _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_talin-F2F3 _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common talin-F2F3 _Molecular_mass . _Mol_thiol_state 'all free' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 201 _Mol_residue_sequence ; DSRDPVQLNLLYVQARDDIL NGSHPVSFDKACEFAGFQCQ IQFGPHNEQKHKAGFLDLKD FLPKEYVKQKGERKIFQAHK NCGQMSEIEAKVRYVKLARS LKTYGVSFFLVKEKMKGKNK LVPRLLGITKECVMRVDEKT KEVIQEWSLTNIKRWAASPK SFTLDFGDYQDGYYSVQTTE GEQIAQLIAGYIDIILKKKK S ; loop_ _Residue_seq_code _Residue_label 1 ASP 2 SER 3 ARG 4 ASP 5 PRO 6 VAL 7 GLN 8 LEU 9 ASN 10 LEU 11 LEU 12 TYR 13 VAL 14 GLN 15 ALA 16 ARG 17 ASP 18 ASP 19 ILE 20 LEU 21 ASN 22 GLY 23 SER 24 HIS 25 PRO 26 VAL 27 SER 28 PHE 29 ASP 30 LYS 31 ALA 32 CYS 33 GLU 34 PHE 35 ALA 36 GLY 37 PHE 38 GLN 39 CYS 40 GLN 41 ILE 42 GLN 43 PHE 44 GLY 45 PRO 46 HIS 47 ASN 48 GLU 49 GLN 50 LYS 51 HIS 52 LYS 53 ALA 54 GLY 55 PHE 56 LEU 57 ASP 58 LEU 59 LYS 60 ASP 61 PHE 62 LEU 63 PRO 64 LYS 65 GLU 66 TYR 67 VAL 68 LYS 69 GLN 70 LYS 71 GLY 72 GLU 73 ARG 74 LYS 75 ILE 76 PHE 77 GLN 78 ALA 79 HIS 80 LYS 81 ASN 82 CYS 83 GLY 84 GLN 85 MET 86 SER 87 GLU 88 ILE 89 GLU 90 ALA 91 LYS 92 VAL 93 ARG 94 TYR 95 VAL 96 LYS 97 LEU 98 ALA 99 ARG 100 SER 101 LEU 102 LYS 103 THR 104 TYR 105 GLY 106 VAL 107 SER 108 PHE 109 PHE 110 LEU 111 VAL 112 LYS 113 GLU 114 LYS 115 MET 116 LYS 117 GLY 118 LYS 119 ASN 120 LYS 121 LEU 122 VAL 123 PRO 124 ARG 125 LEU 126 LEU 127 GLY 128 ILE 129 THR 130 LYS 131 GLU 132 CYS 133 VAL 134 MET 135 ARG 136 VAL 137 ASP 138 GLU 139 LYS 140 THR 141 LYS 142 GLU 143 VAL 144 ILE 145 GLN 146 GLU 147 TRP 148 SER 149 LEU 150 THR 151 ASN 152 ILE 153 LYS 154 ARG 155 TRP 156 ALA 157 ALA 158 SER 159 PRO 160 LYS 161 SER 162 PHE 163 THR 164 LEU 165 ASP 166 PHE 167 GLY 168 ASP 169 TYR 170 GLN 171 ASP 172 GLY 173 TYR 174 TYR 175 SER 176 VAL 177 GLN 178 THR 179 THR 180 GLU 181 GLY 182 GLU 183 GLN 184 ILE 185 ALA 186 GLN 187 LEU 188 ILE 189 ALA 190 GLY 191 TYR 192 ILE 193 ASP 194 ILE 195 ILE 196 LEU 197 LYS 198 LYS 199 LYS 200 LYS 201 SER stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2015-08-05 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value BMRB 16930 F2 52.24 120 100.00 100.00 3.62e-70 BMRB 16932 F2F3 100.00 216 100.00 100.00 3.60e-145 PDB 1MIX "Crystal Structure Of A Ferm Domain Of Talin" 97.51 206 96.94 98.47 8.12e-139 PDB 1MIZ "Crystal Structure Of An Integrin Beta3-Talin Chimera" 97.51 201 96.94 98.47 8.47e-139 PDB 1Y19 "Structural Basis For Phosphatidylinositol Phosphate Kinase Type I-Gamma Binding To Talin At Focal Adhesions" 98.01 202 100.00 100.00 4.49e-142 PDB 3IVF "Crystal Structure Of The Talin Head Ferm Domain" 97.51 371 100.00 100.00 1.06e-140 PDB 4F7G "Crystal Structure Of Talin Autoinhibition Complex" 99.50 222 100.00 100.00 7.53e-145 DBJ BAA82979 "KIAA1027 protein [Homo sapiens]" 100.00 2550 99.50 100.00 3.53e-131 DBJ BAC30516 "unnamed protein product [Mus musculus]" 97.01 300 100.00 100.00 1.58e-141 DBJ BAC65702 "mKIAA1027 protein [Mus musculus]" 100.00 2564 100.00 100.00 1.35e-131 DBJ BAE27781 "unnamed protein product [Mus musculus]" 100.00 2541 100.00 100.00 1.30e-131 DBJ BAG09941 "talin-1 [synthetic construct]" 100.00 2541 99.50 100.00 3.48e-131 EMBL CAA39588 "talin [Mus musculus]" 100.00 2541 100.00 100.00 1.05e-131 GB AAD13152 "talin [Homo sapiens]" 100.00 2541 99.50 100.00 2.92e-131 GB AAF23322 "talin [Homo sapiens]" 100.00 2541 99.50 100.00 2.92e-131 GB AAF27330 "talin [Homo sapiens]" 100.00 2540 99.50 100.00 3.48e-131 GB AAH42923 "Talin 1 [Homo sapiens]" 100.00 2541 99.50 100.00 3.13e-131 GB AAI22767 "TLN1 protein [Bos taurus]" 99.50 407 99.50 100.00 1.21e-142 PRF 1617167A talin 100.00 2541 100.00 100.00 1.05e-131 REF NP_001034114 "talin-1 [Rattus norvegicus]" 100.00 2541 100.00 100.00 1.17e-131 REF NP_001192357 "talin-1 [Bos taurus]" 100.00 2541 99.50 100.00 3.13e-131 REF NP_006280 "talin-1 [Homo sapiens]" 100.00 2541 99.50 100.00 3.48e-131 REF NP_035732 "talin-1 [Mus musculus]" 100.00 2541 100.00 100.00 1.30e-131 REF NP_989854 "talin-1 [Gallus gallus]" 100.00 2541 97.01 98.51 6.81e-127 SP P26039 "RecName: Full=Talin-1" 100.00 2541 100.00 100.00 1.30e-131 SP P54939 "RecName: Full=Talin-1" 100.00 2541 97.01 98.51 6.81e-127 SP Q9Y490 "RecName: Full=Talin-1" 100.00 2541 99.50 100.00 3.48e-131 TPG DAA26829 "TPA: talin 1 [Bos taurus]" 100.00 2541 99.50 100.00 3.13e-131 stop_ save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $talin-F2F3 Human 9606 Eukaryota Metazoa Homo sapiens stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $talin-F2F3 'recombinant technology' . Escherichia coli . pET15b stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $talin-F2F3 0.2 mM '[U-100% 15N]' NaCl 150 mM . H2O 90 % 'natural abundance' D2O 10 % . stop_ save_ ############################ # Computer software used # ############################ save_PIPP _Saveframe_category software _Name PIPP _Version . loop_ _Vendor _Address _Electronic_address Garrett . . stop_ loop_ _Task 'chemical shift assignment' stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model Avance _Field_strength 900 _Details . save_ ############################# # NMR applied experiments # ############################# save_2D_1H-15N_HSQC_1 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-15N HSQC' _Sample_label $sample_1 save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units 'ionic strength' 0.15 . M pH 6.8 . pH pressure 1 . atm temperature 298 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS H 1 'methyl protons' ppm 0 external indirect . . . 1.0 'liquid anhydrous ammonia' N 15 nitrogen ppm 119.0 external indirect . . . 1.0 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chem_shift_list_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Experiment_label '2D 1H-15N HSQC' stop_ loop_ _Sample_label $sample_1 stop_ _Sample_conditions_label $sample_conditions_1 _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name talin-F2F3 _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 205 1 ASP H H 8.5 . 1 2 205 1 ASP N N 124.23 . 1 3 207 3 ARG H H 8.24 . 1 4 207 3 ARG N N 120.91 . 1 5 208 4 ASP H H 7.89 . 1 6 208 4 ASP N N 118.66 . 1 7 210 6 VAL H H 8.02 . 1 8 210 6 VAL N N 121.03 . 1 9 211 7 GLN H H 7.63 . 1 10 211 7 GLN N N 120.81 . 1 11 212 8 LEU H H 8.34 . 1 12 212 8 LEU N N 119.69 . 1 13 213 9 ASN H H 7.96 . 1 14 213 9 ASN N N 115.75 . 1 15 214 10 LEU H H 7.59 . 1 16 214 10 LEU N N 118.31 . 1 17 215 11 LEU H H 7.94 . 1 18 215 11 LEU N N 119.44 . 1 19 216 12 TYR H H 8.57 . 1 20 216 12 TYR N N 118.92 . 1 21 217 13 VAL H H 8.46 . 1 22 217 13 VAL N N 118.09 . 1 23 218 14 GLN H H 7.28 . 1 24 218 14 GLN N N 116.59 . 1 25 219 15 ALA H H 7.85 . 1 26 219 15 ALA N N 120.42 . 1 27 220 16 ARG H H 8.69 . 1 28 220 16 ARG N N 119.44 . 1 29 221 17 ASP H H 8.76 . 1 30 221 17 ASP N N 120.4 . 1 31 222 18 ASP H H 7.74 . 1 32 222 18 ASP N N 118.67 . 1 33 223 19 ILE H H 7.58 . 1 34 223 19 ILE N N 123.93 . 1 35 224 20 LEU H H 9.15 . 1 36 224 20 LEU N N 120.48 . 1 37 225 21 ASN H H 8.74 . 1 38 225 21 ASN N N 114.32 . 1 39 226 22 GLY H H 7.51 . 1 40 226 22 GLY N N 107.54 . 1 41 227 23 SER H H 8.46 . 1 42 227 23 SER N N 118.09 . 1 43 228 24 HIS H H 7.63 . 1 44 228 24 HIS N N 120.39 . 1 45 232 28 PHE H H 9.24 . 1 46 232 28 PHE N N 123.91 . 1 47 233 29 ASP H H 8.48 . 1 48 233 29 ASP N N 117.29 . 1 49 234 30 LYS H H 7.64 . 1 50 234 30 LYS N N 119.51 . 1 51 235 31 ALA H H 9.23 . 1 52 235 31 ALA N N 121.53 . 1 53 236 32 CYS H H 7.74 . 1 54 236 32 CYS N N 115.69 . 1 55 237 33 GLU H H 7.27 . 1 56 237 33 GLU N N 121.72 . 1 57 238 34 PHE H H 8.73 . 1 58 238 34 PHE N N 119.02 . 1 59 239 35 ALA H H 8.32 . 1 60 239 35 ALA N N 120.02 . 1 61 240 36 GLY H H 8.17 . 1 62 240 36 GLY N N 107.32 . 1 63 241 37 PHE H H 7.38 . 1 64 241 37 PHE N N 119.39 . 1 65 242 38 GLN H H 9.18 . 1 66 242 38 GLN N N 121.97 . 1 67 243 39 CYS H H 8.89 . 1 68 243 39 CYS N N 118 . 1 69 244 40 GLN H H 7.68 . 1 70 244 40 GLN N N 123.26 . 1 71 245 41 ILE H H 8.34 . 1 72 245 41 ILE N N 119.69 . 1 73 246 42 GLN H H 8.32 . 1 74 246 42 GLN N N 115.92 . 1 75 247 43 PHE H H 8.99 . 1 76 247 43 PHE N N 115.13 . 1 77 248 44 GLY H H 7.71 . 1 78 248 44 GLY N N 111.37 . 1 79 250 46 HIS H H 8.95 . 1 80 250 46 HIS N N 124.38 . 1 81 251 47 ASN H H 10.12 . 1 82 251 47 ASN N N 130.88 . 1 83 252 48 GLU H H 9.19 . 1 84 252 48 GLU N N 125.93 . 1 85 253 49 GLN H H 7.62 . 1 86 253 49 GLN N N 114.71 . 1 87 254 50 LYS H H 6.86 . 1 88 254 50 LYS N N 116.39 . 1 89 255 51 HIS H H 7.83 . 1 90 255 51 HIS N N 122.36 . 1 91 256 52 LYS H H 6.65 . 1 92 256 52 LYS N N 118.28 . 1 93 257 53 ALA H H 8.44 . 1 94 257 53 ALA N N 122.1 . 1 95 258 54 GLY H H 10.15 . 1 96 258 54 GLY N N 114.49 . 1 97 259 55 PHE H H 8.63 . 1 98 259 55 PHE N N 121.79 . 1 99 260 56 LEU H H 8.05 . 1 100 260 56 LEU N N 115.91 . 1 101 261 57 ASP H H 8.77 . 1 102 261 57 ASP N N 123.31 . 1 103 262 58 LEU H H 8.63 . 1 104 262 58 LEU N N 124.96 . 1 105 263 59 LYS H H 8.38 . 1 106 263 59 LYS N N 116.47 . 1 107 264 60 ASP H H 8.05 . 1 108 264 60 ASP N N 117.75 . 1 109 265 61 PHE H H 7.54 . 1 110 265 61 PHE N N 115.04 . 1 111 266 62 LEU H H 7.51 . 1 112 266 62 LEU N N 118.18 . 1 113 268 64 LYS H H 8.58 . 1 114 268 64 LYS N N 123.24 . 1 115 269 65 GLU H H 9.16 . 1 116 269 65 GLU N N 116.72 . 1 117 270 66 TYR H H 8.05 . 1 118 270 66 TYR N N 117.75 . 1 119 271 67 VAL H H 7.34 . 1 120 271 67 VAL N N 119.55 . 1 121 272 68 LYS H H 8.4 . 1 122 272 68 LYS N N 118.2 . 1 123 273 69 GLN H H 7.54 . 1 124 273 69 GLN N N 118.94 . 1 125 274 70 LYS H H 8.42 . 1 126 274 70 LYS N N 118.59 . 1 127 275 71 GLY H H 8.45 . 1 128 275 71 GLY N N 106.7 . 1 129 276 72 GLU H H 8.91 . 1 130 276 72 GLU N N 121.32 . 1 131 277 73 ARG H H 8.51 . 1 132 277 73 ARG N N 116.51 . 1 133 278 74 LYS H H 7.54 . 1 134 278 74 LYS N N 119.63 . 1 135 279 75 ILE H H 8.11 . 1 136 279 75 ILE N N 122.45 . 1 137 280 76 PHE H H 8.51 . 1 138 280 76 PHE N N 118.01 . 1 139 281 77 GLN H H 8.04 . 1 140 281 77 GLN N N 120.35 . 1 141 282 78 ALA H H 7.52 . 1 142 282 78 ALA N N 122.74 . 1 143 283 79 HIS H H 8.97 . 1 144 283 79 HIS N N 120.2 . 1 145 284 80 LYS H H 8.63 . 1 146 284 80 LYS N N 122.27 . 1 147 285 81 ASN H H 8.07 . 1 148 285 81 ASN N N 117.99 . 1 149 286 82 CYS H H 7.73 . 1 150 286 82 CYS N N 117.01 . 1 151 287 83 GLY H H 7.93 . 1 152 287 83 GLY N N 108.83 . 1 153 288 84 GLN H H 8.99 . 1 154 288 84 GLN N N 124.48 . 1 155 289 85 MET H H 7.41 . 1 156 289 85 MET N N 121.37 . 1 157 290 86 SER H H 9 . 1 158 290 86 SER N N 122.3 . 1 159 291 87 GLU H H 8.9 . 1 160 291 87 GLU N N 121.29 . 1 161 292 88 ILE H H 7.7 . 1 162 292 88 ILE N N 116.48 . 1 163 302 98 ALA H H 8.34 . 1 164 302 98 ALA N N 121.2 . 1 165 303 99 ARG H H 7.86 . 1 166 303 99 ARG N N 119 . 1 167 307 103 THR H H 7.4 . 1 168 307 103 THR N N 116.07 . 1 169 308 104 TYR H H 7.61 . 1 170 308 104 TYR N N 124.57 . 1 171 309 105 GLY H H 8.32 . 1 172 309 105 GLY N N 116.92 . 1 173 310 106 VAL H H 7.08 . 1 174 310 106 VAL N N 121.76 . 1 175 311 107 SER H H 7.51 . 1 176 311 107 SER N N 122.1 . 1 177 312 108 PHE H H 8.69 . 1 178 312 108 PHE N N 123.23 . 1 179 313 109 PHE H H 9.23 . 1 180 313 109 PHE N N 119.35 . 1 181 314 110 LEU H H 9.44 . 1 182 314 110 LEU N N 127.12 . 1 183 315 111 VAL H H 9.34 . 1 184 315 111 VAL N N 123.58 . 1 185 316 112 LYS H H 8.43 . 1 186 316 112 LYS N N 116.55 . 1 187 317 113 GLU H H 9.26 . 1 188 317 113 GLU N N 123.46 . 1 189 318 114 LYS H H 8.87 . 1 190 318 114 LYS N N 124.14 . 1 191 319 115 MET H H 8.95 . 1 192 319 115 MET N N 127.07 . 1 193 320 116 LYS H H 8.65 . 1 194 320 116 LYS N N 125.11 . 1 195 322 118 LYS H H 7.74 . 1 196 322 118 LYS N N 118.67 . 1 197 330 126 LEU H H 9.79 . 1 198 330 126 LEU N N 127.93 . 1 199 331 127 GLY H H 9.79 . 1 200 331 127 GLY N N 114.4 . 1 201 332 128 ILE H H 8.74 . 1 202 332 128 ILE N N 123.59 . 1 203 333 129 THR H H 9.07 . 1 204 333 129 THR N N 121.76 . 1 205 334 130 LYS H H 7.64 . 1 206 334 130 LYS N N 113.05 . 1 207 335 131 GLU H H 7.97 . 1 208 335 131 GLU N N 111.96 . 1 209 336 132 CYS H H 8.09 . 1 210 336 132 CYS N N 118.99 . 1 211 337 133 VAL H H 8.81 . 1 212 337 133 VAL N N 118.21 . 1 213 338 134 MET H H 9.82 . 1 214 338 134 MET N N 122.42 . 1 215 339 135 ARG H H 8.75 . 1 216 339 135 ARG N N 122.17 . 1 217 340 136 VAL H H 9.54 . 1 218 340 136 VAL N N 126.41 . 1 219 341 137 ASP H H 8.74 . 1 220 341 137 ASP N N 128.36 . 1 221 342 138 GLU H H 9.44 . 1 222 342 138 GLU N N 128.74 . 1 223 343 139 LYS H H 8.78 . 1 224 343 139 LYS N N 119.42 . 1 225 344 140 THR H H 8.75 . 1 226 344 140 THR N N 109.7 . 1 227 345 141 LYS H H 7.85 . 1 228 345 141 LYS N N 117.05 . 1 229 346 142 GLU H H 7.51 . 1 230 346 142 GLU N N 116.42 . 1 231 347 143 VAL H H 8.84 . 1 232 347 143 VAL N N 124.45 . 1 233 348 144 ILE H H 9 . 1 234 348 144 ILE N N 128.42 . 1 235 349 145 GLN H H 7.43 . 1 236 349 145 GLN N N 118.26 . 1 237 350 146 GLU H H 8.15 . 1 238 350 146 GLU N N 123.12 . 1 239 351 147 TRP H H 9.38 . 1 240 351 147 TRP N N 122.33 . 1 241 352 148 SER H H 8.81 . 1 242 352 148 SER N N 117.44 . 1 243 353 149 LEU H H 8.22 . 1 244 353 149 LEU N N 126.74 . 1 245 354 150 THR H H 7.83 . 1 246 354 150 THR N N 105.77 . 1 247 355 151 ASN H H 7.77 . 1 248 355 151 ASN N N 118.19 . 1 249 356 152 ILE H H 7.38 . 1 250 356 152 ILE N N 119.39 . 1 251 357 153 LYS H H 9.02 . 1 252 357 153 LYS N N 128.14 . 1 253 358 154 ARG H H 7.94 . 1 254 358 154 ARG N N 114.91 . 1 255 359 155 TRP H H 7.34 . 1 256 359 155 TRP N N 117.8 . 1 257 360 156 ALA H H 8.37 . 1 258 360 156 ALA N N 120.6 . 1 259 361 157 ALA H H 9.01 . 1 260 361 157 ALA N N 124.55 . 1 261 362 158 SER H H 8.99 . 1 262 362 158 SER N N 120.84 . 1 263 364 160 LYS H H 8.37 . 1 264 364 160 LYS N N 120.61 . 1 265 365 161 SER H H 7.78 . 1 266 365 161 SER N N 115.08 . 1 267 366 162 PHE H H 8.67 . 1 268 366 162 PHE N N 119.65 . 1 269 367 163 THR H H 7.99 . 1 270 367 163 THR N N 122.64 . 1 271 368 164 LEU H H 9.02 . 1 272 368 164 LEU N N 124.28 . 1 273 369 165 ASP H H 8 . 1 274 369 165 ASP N N 120.12 . 1 275 370 166 PHE H H 8.95 . 1 276 370 166 PHE N N 124.38 . 1 277 371 167 GLY H H 9.09 . 1 278 371 167 GLY N N 110.54 . 1 279 372 168 ASP H H 8.52 . 1 280 372 168 ASP N N 122.18 . 1 281 373 169 TYR H H 8.16 . 1 282 373 169 TYR N N 120.35 . 1 283 374 170 GLN H H 8.19 . 1 284 374 170 GLN N N 119.51 . 1 285 375 171 ASP H H 8.32 . 1 286 375 171 ASP N N 120.02 . 1 287 376 172 GLY H H 8.14 . 1 288 376 172 GLY N N 109.66 . 1 289 377 173 TYR H H 7.97 . 1 290 377 173 TYR N N 120.44 . 1 291 378 174 TYR H H 8.74 . 1 292 378 174 TYR N N 124.88 . 1 293 379 175 SER H H 8.32 . 1 294 379 175 SER N N 122.12 . 1 295 380 176 VAL H H 8.87 . 1 296 380 176 VAL N N 117.04 . 1 297 381 177 GLN H H 9.19 . 1 298 381 177 GLN N N 121 . 1 299 382 178 THR H H 7.99 . 1 300 382 178 THR N N 121.37 . 1 301 383 179 THR H H 8.76 . 1 302 383 179 THR N N 118.16 . 1 303 384 180 GLU H H 9.19 . 1 304 384 180 GLU N N 124.32 . 1 305 385 181 GLY H H 9.28 . 1 306 385 181 GLY N N 110.73 . 1 307 386 182 GLU H H 8.83 . 1 308 386 182 GLU N N 119.69 . 1 309 387 183 GLN H H 7.48 . 1 310 387 183 GLN N N 119.49 . 1 311 388 184 ILE H H 7.53 . 1 312 388 184 ILE N N 121.48 . 1 313 389 185 ALA H H 8.27 . 1 314 389 185 ALA N N 119.68 . 1 315 390 186 GLN H H 7.63 . 1 316 390 186 GLN N N 115.31 . 1 317 391 187 LEU H H 7.33 . 1 318 391 187 LEU N N 121.32 . 1 319 392 188 ILE H H 7.79 . 1 320 392 188 ILE N N 117.8 . 1 321 393 189 ALA H H 7.81 . 1 322 393 189 ALA N N 111.32 . 1 323 394 190 GLY H H 7.57 . 1 324 394 190 GLY N N 103.81 . 1 325 395 191 TYR H H 7.61 . 1 326 395 191 TYR N N 121.21 . 1 327 396 192 ILE H H 8.83 . 1 328 396 192 ILE N N 123.05 . 1 329 397 193 ASP H H 7.96 . 1 330 397 193 ASP N N 120.15 . 1 331 398 194 ILE H H 7.65 . 1 332 398 194 ILE N N 121.44 . 1 333 399 195 ILE H H 7.61 . 1 334 399 195 ILE N N 121.21 . 1 335 400 196 LEU H H 8.25 . 1 336 400 196 LEU N N 120.07 . 1 337 401 197 LYS H H 7.79 . 1 338 401 197 LYS N N 119.07 . 1 339 402 198 LYS H H 7.88 . 1 340 402 198 LYS N N 120.66 . 1 341 403 199 LYS H H 7.81 . 1 342 403 199 LYS N N 119.76 . 1 343 404 200 LYS H H 7.36 . 1 344 404 200 LYS N N 123.26 . 1 345 405 201 SER H H 7.99 . 1 346 405 201 SER N N 123.14 . 1 stop_ save_