data_5382 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; 1H, 13C, and 15N backbone resonance assignment of the C-terminal domain of EPSP synthase ; _BMRB_accession_number 5382 _BMRB_flat_file_name bmr5382.str _Entry_type original _Submission_date 2002-06-04 _Accession_date 2002-06-04 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Kim Hak Jun . 2 Young John K. . 3 Helms Gregory L. . 4 Evans Jeremy N.S. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 404 "13C chemical shifts" 384 "15N chemical shifts" 194 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2002-12-23 original author . stop_ _Original_release_date 2002-12-23 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; Letter to the Editor: 1H, 13C, and 15N backbone resonance assignments of the C-terminal domain of 5'-enolpyruvylshikimate-3-phosphate synthase ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID ? loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Kim Hak Jun . 2 Young John K. . 3 Helms Gregory L. . 4 Evans Jeremy N.S. . stop_ _Journal_abbreviation 'J. Biomol. NMR' _Journal_volume 24 _Journal_issue 3 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 269 _Page_last 270 _Year 2002 _Details . loop_ _Keyword 'backbone assignments' 'EPSP synthase' glyphosate phosphoenolpyruvate 'protein engineering' stop_ save_ ####################################### # Cited references within the entry # ####################################### save_ref_1 _Saveframe_category citation _Citation_full ; Stauffer, M.E., Young, J.K., Helms, G.L.., and Evans, J.N.S. FEBS Letters 499 (2001), 182-186. ; _Citation_title 'Chemical shift mapping of shikimate-3-phosphate binding to the isolated N-terminal domain of 5-enolpyruvylshikimate-3-phosphate synthase.' _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 11418136 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Stauffer 'M E' E. . 2 Young 'J K' K. . 3 Helms 'G L' L. . 4 Evans 'J N' N. . stop_ _Journal_abbreviation 'FEBS Lett.' _Journal_name_full 'FEBS letters' _Journal_volume 499 _Journal_issue 1-2 _Journal_CSD . _Book_title . _Book_chapter_title . _Book_volume . _Book_series . _Book_publisher . _Book_publisher_city . _Book_ISBN . _Conference_title . _Conference_site . _Conference_state_province . _Conference_country . _Conference_start_date . _Conference_end_date . _Conference_abstract_number . _Thesis_institution . _Thesis_institution_city . _Thesis_institution_country . _Page_first 182 _Page_last 186 _Year 2001 _Details ; To facilitate evaluation of enzyme-ligand complexes in solution, we have isolated the 26-kDa N-terminal domain of 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase for analysis by NMR spectroscopy. The isolated domain is capable of binding the substrate shikimate-3-phosphate (S3P), and this letter reports the localization of the S3P binding site using chemical shift mapping. Based on the NMR data, we propose that Ser23, Arg27, Ser197, and Tyr200 are directly involved in S3P binding. We also describe changes in the observed nuclear Overhauser effects (NOEs) that are consistent with a partial conformational change in the N-terminal domain upon S3P binding. ; save_ ################################## # Molecular system description # ################################## save_system_EPSP_synthase _Saveframe_category molecular_system _Mol_system_name 'the C-terminal domain of EPSP synthase' _Abbreviation_common 'EPSP synthase' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'C-terminal domain of EPSP synthase' $EPSPS stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state monomer _System_paramagnetic no _System_thiol_state 'not reported' _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_EPSPS _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common 'EPSP synthase' _Abbreviation_common EPSPS _Molecular_mass 22980 _Mol_thiol_state 'not reported' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 211 _Mol_residue_sequence ; MESLTLQPIARVDGTINLPG SGGEGDASSASTFLAAAAIK GGTVKVTGIGRNSMQGDIRF ADVLEKMGATICWGDDTISC TRGELNAIDMDMNHIPDAAM TIATAALFAKGTTTLRNITN WRVKETDRLFAMATELRKVG AEVEEGHDTIRITPPEKLNF AEIATTNDHRMAMCFSLVAL SDTPVTILDPKCTAKTFPDT FEQLARISQAA ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 1 MET 2 2 GLU 3 3 SER 4 4 LEU 5 5 THR 6 6 LEU 7 7 GLN 8 8 PRO 9 9 ILE 10 10 ALA 11 11 ARG 12 12 VAL 13 13 ASP 14 14 GLY 15 15 THR 16 16 ILE 17 17 ASN 18 18 LEU 19 19 PRO 20 20 GLY 21 21 SER 22 22 GLY 23 23 GLY 24 240 GLU 25 241 GLY 26 242 ASP 27 243 ALA 28 244 SER 29 245 SER 30 246 ALA 31 247 SER 32 248 THR 33 249 PHE 34 250 LEU 35 251 ALA 36 252 ALA 37 253 ALA 38 254 ALA 39 255 ILE 40 256 LYS 41 257 GLY 42 258 GLY 43 259 THR 44 260 VAL 45 261 LYS 46 262 VAL 47 263 THR 48 264 GLY 49 265 ILE 50 266 GLY 51 267 ARG 52 268 ASN 53 269 SER 54 270 MET 55 271 GLN 56 272 GLY 57 273 ASP 58 274 ILE 59 275 ARG 60 276 PHE 61 277 ALA 62 278 ASP 63 279 VAL 64 280 LEU 65 281 GLU 66 282 LYS 67 283 MET 68 284 GLY 69 285 ALA 70 286 THR 71 287 ILE 72 288 CYS 73 289 TRP 74 290 GLY 75 291 ASP 76 292 ASP 77 293 THR 78 294 ILE 79 295 SER 80 296 CYS 81 297 THR 82 298 ARG 83 299 GLY 84 300 GLU 85 301 LEU 86 302 ASN 87 303 ALA 88 304 ILE 89 305 ASP 90 306 MET 91 307 ASP 92 308 MET 93 309 ASN 94 310 HIS 95 311 ILE 96 312 PRO 97 313 ASP 98 314 ALA 99 315 ALA 100 316 MET 101 317 THR 102 318 ILE 103 319 ALA 104 320 THR 105 321 ALA 106 322 ALA 107 323 LEU 108 324 PHE 109 325 ALA 110 326 LYS 111 327 GLY 112 328 THR 113 329 THR 114 330 THR 115 331 LEU 116 332 ARG 117 333 ASN 118 334 ILE 119 335 THR 120 336 ASN 121 337 TRP 122 338 ARG 123 339 VAL 124 340 LYS 125 341 GLU 126 342 THR 127 343 ASP 128 344 ARG 129 345 LEU 130 346 PHE 131 347 ALA 132 348 MET 133 349 ALA 134 350 THR 135 351 GLU 136 352 LEU 137 353 ARG 138 354 LYS 139 355 VAL 140 356 GLY 141 357 ALA 142 358 GLU 143 359 VAL 144 360 GLU 145 361 GLU 146 362 GLY 147 363 HIS 148 364 ASP 149 365 THR 150 366 ILE 151 367 ARG 152 368 ILE 153 369 THR 154 370 PRO 155 371 PRO 156 372 GLU 157 373 LYS 158 374 LEU 159 375 ASN 160 376 PHE 161 377 ALA 162 378 GLU 163 379 ILE 164 380 ALA 165 381 THR 166 382 THR 167 383 ASN 168 384 ASP 169 385 HIS 170 386 ARG 171 387 MET 172 388 ALA 173 389 MET 174 390 CYS 175 391 PHE 176 392 SER 177 393 LEU 178 394 VAL 179 395 ALA 180 396 LEU 181 397 SER 182 398 ASP 183 399 THR 184 400 PRO 185 401 VAL 186 402 THR 187 403 ILE 188 404 LEU 189 405 ASP 190 406 PRO 191 407 LYS 192 408 CYS 193 409 THR 194 410 ALA 195 411 LYS 196 412 THR 197 413 PHE 198 414 PRO 199 415 ASP 200 416 THR 201 417 PHE 202 418 GLU 203 419 GLN 204 420 LEU 205 421 ALA 206 422 ARG 207 423 ILE 208 424 SER 209 425 GLN 210 426 ALA 211 427 ALA stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2005-12-09 save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $EPSPS 'E. coli' 562 Eubacteria . Escherichia coli stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $EPSPS 'recombinant technology' . . . . . stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $EPSPS 1.0 mM '[U-95% 13C; U-90% 15N]' Tris 10 mM . DTT 1 mM . NaN3 3 mM . D2O 50 % . stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_list _Saveframe_category NMR_spectrometer _Manufacturer unknown _Model unknown _Field_strength 0 _Details 'spectrometer information not available' save_ ####################### # Sample conditions # ####################### save_C-term_cond_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 7.8 0.2 n/a temperature 295 1 K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.0 . indirect . . . 0.251449530 DSS H 1 'methyl protons' ppm 0.0 internal direct . . . 1.0 DSS N 15 'methyl protons' ppm 0.0 . indirect . . . 0.101329118 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_Cterminal_domain_chemical_shift _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_1 stop_ _Sample_conditions_label $C-term_cond_1 _Chem_shift_reference_set_label $chemical_shift_reference _Mol_system_component_name 'C-terminal domain of EPSP synthase' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 2 2 GLU CA C 56.75 . . 2 2 2 GLU HA H 4.42 . . 3 3 3 SER N N 114.38 . . 4 3 3 SER H H 8.32 . . 5 3 3 SER CA C 56.84 . . 6 3 3 SER HA H 4.97 . . 7 3 3 SER C C 171.91 . . 8 4 4 LEU N N 122.26 . . 9 4 4 LEU H H 8.47 . . 10 4 4 LEU CA C 53.92 . . 11 4 4 LEU HA H 4.62 . . 12 4 4 LEU C C 174.66 . . 13 5 5 THR N N 124.39 . . 14 5 5 THR H H 9.06 . . 15 5 5 THR CA C 61.95 . . 16 5 5 THR HA H 5.22 . . 17 5 5 THR C C 173.86 . . 18 6 6 LEU N N 130.98 . . 19 6 6 LEU H H 9.21 . . 20 6 6 LEU CA C 53.55 . . 21 6 6 LEU HA H 4.49 . . 22 6 6 LEU C C 175.2 . . 23 7 7 GLN N N 119.49 . . 24 7 7 GLN H H 8.01 . . 25 7 7 GLN CA C 52.84 . . 26 7 7 GLN HA H 4.31 . . 27 7 7 GLN C C 173.33 . . 28 8 8 PRO CA C 63.14 . . 29 8 8 PRO HA H 4.8 . . 30 8 8 PRO C C 177.1 . . 31 9 9 ILE N N 127.5 . . 32 9 9 ILE H H 9.01 . . 33 9 9 ILE CA C 60.67 . . 34 9 9 ILE HA H 4.32 . . 35 9 9 ILE C C 175.64 . . 36 10 10 ALA N N 129.1 . . 37 10 10 ALA H H 8.66 . . 38 10 10 ALA CA C 54.14 . . 39 10 10 ALA HA H 4.03 . . 40 10 10 ALA C C 177.57 . . 41 11 11 ARG N N 116.16 . . 42 11 11 ARG H H 7.47 . . 43 11 11 ARG CA C 54.85 . . 44 11 11 ARG HA H 4.86 . . 45 11 11 ARG C C 173.66 . . 46 12 12 VAL N N 116.19 . . 47 12 12 VAL H H 7.52 . . 48 12 12 VAL CA C 58.15 . . 49 12 12 VAL HA H 5.42 . . 50 12 12 VAL C C 174.29 . . 51 13 13 ASP N N 118.87 . . 52 13 13 ASP H H 8.49 . . 53 13 13 ASP CA C 54.73 . . 54 13 13 ASP HA H 5.23 . . 55 13 13 ASP C C 174.92 . . 56 14 14 GLY N N 110.67 . . 57 14 14 GLY H H 8.79 . . 58 14 14 GLY CA C 44.77 . . 59 14 14 GLY HA2 H 3.86 . . 60 14 14 GLY HA3 H 4.7 . . 61 15 15 THR N N 116.55 . . 62 15 15 THR H H 8.48 . . 63 15 15 THR CA C 60.86 . . 64 15 15 THR HA H 5.35 . . 65 15 15 THR C C 173.25 . . 66 16 16 ILE N N 127.08 . . 67 16 16 ILE H H 9.06 . . 68 16 16 ILE CA C 57.28 . . 69 16 16 ILE HA H 4.78 . . 70 16 16 ILE C C 173.17 . . 71 17 17 ASN N N 125.22 . . 72 17 17 ASN H H 8.69 . . 73 17 17 ASN CA C 51.06 . . 74 17 17 ASN HA H 5.11 . . 75 17 17 ASN C C 174.4 . . 76 18 18 LEU N N 126.24 . . 77 18 18 LEU H H 8.34 . . 78 18 18 LEU CA C 53.14 . . 79 18 18 LEU HA H 4.29 . . 80 18 18 LEU C C 174.91 . . 81 19 19 PRO CA C 62.76 . . 82 19 19 PRO C C 177.52 . . 83 20 20 GLY N N 108.76 . . 84 20 20 GLY H H 8.31 . . 85 20 20 GLY CA C 45.36 . . 86 21 21 SER N N 115.46 . . 87 21 21 SER H H 8.29 . . 88 21 21 SER CA C 58.03 . . 89 21 21 SER C C 175.22 . . 90 22 22 GLY N N 110.91 . . 91 22 22 GLY H H 8.64 . . 92 22 22 GLY CA C 45.17 . . 93 22 22 GLY HA2 H 3.99 . . 94 23 23 GLY N N 108.94 . . 95 23 23 GLY H H 8.31 . . 96 23 23 GLY CA C 44.87 . . 97 23 23 GLY HA2 H 3.89 . . 98 23 23 GLY HA3 H 4.02 . . 99 240 24 GLU N N 120.69 . . 100 240 24 GLU H H 8.45 . . 101 240 24 GLU CA C 56.5 . . 102 240 24 GLU HA H 4.3 . . 103 240 24 GLU C C 177.2 . . 104 241 25 GLY N N 109.91 . . 105 241 25 GLY H H 8.52 . . 106 241 25 GLY CA C 45.16 . . 107 241 25 GLY HA2 H 3.93 . . 108 242 26 ASP N N 120.23 . . 109 242 26 ASP H H 8.15 . . 110 242 26 ASP CA C 53.94 . . 111 242 26 ASP HA H 4.48 . . 112 242 26 ASP C C 175.86 . . 113 243 27 ALA N N 124.17 . . 114 243 27 ALA H H 8.28 . . 115 243 27 ALA CA C 52.43 . . 116 243 27 ALA HA H 4.78 . . 117 243 27 ALA C C 177.86 . . 118 244 28 SER N N 116.68 . . 119 244 28 SER H H 8.86 . . 120 244 28 SER CA C 58.31 . . 121 244 28 SER HA H 4.39 . . 122 245 29 SER CA C 60.22 . . 123 245 29 SER C C 176.74 . . 124 246 30 ALA N N 123.04 . . 125 246 30 ALA H H 8.11 . . 126 246 30 ALA CA C 55.1 . . 127 246 30 ALA HA H 4.16 . . 128 247 31 SER CA C 61.1 . . 129 247 31 SER C C 175.46 . . 130 248 32 THR N N 120.14 . . 131 248 32 THR H H 6.08 . . 132 248 32 THR CA C 60.27 . . 133 248 32 THR HA H 4.02 . . 134 248 32 THR C C 176.58 . . 135 249 33 PHE N N 114 . . 136 249 33 PHE H H 6.64 . . 137 249 33 PHE CA C 59.94 . . 138 249 33 PHE HA H 4.03 . . 139 249 33 PHE C C 177.19 . . 140 250 34 LEU N N 116.31 . . 141 250 34 LEU H H 7.75 . . 142 250 34 LEU CA C 57.12 . . 143 250 34 LEU HA H 4.01 . . 144 250 34 LEU C C 178.74 . . 145 251 35 ALA N N 119.15 . . 146 251 35 ALA H H 8.62 . . 147 251 35 ALA CA C 54.53 . . 148 251 35 ALA HA H 3.85 . . 149 251 35 ALA C C 178.41 . . 150 252 36 ALA N N 117.52 . . 151 252 36 ALA H H 7.94 . . 152 252 36 ALA CA C 54.56 . . 153 252 36 ALA HA H 4.03 . . 154 252 36 ALA C C 179.04 . . 155 253 37 ALA N N 119.21 . . 156 253 37 ALA H H 7.18 . . 157 253 37 ALA CA C 53.65 . . 158 253 37 ALA HA H 3.62 . . 159 253 37 ALA C C 178.69 . . 160 254 38 ALA N N 119.58 . . 161 254 38 ALA H H 7.72 . . 162 254 38 ALA CA C 53.72 . . 163 254 38 ALA HA H 3.82 . . 164 254 38 ALA C C 178.53 . . 165 255 39 ILE N N 116.25 . . 166 255 39 ILE H H 7.72 . . 167 255 39 ILE CA C 63.54 . . 168 255 39 ILE HA H 4.25 . . 169 255 39 ILE C C 176.69 . . 170 256 40 LYS N N 121.27 . . 171 256 40 LYS H H 8.61 . . 172 256 40 LYS CA C 52.67 . . 173 256 40 LYS HA H 5.36 . . 174 256 40 LYS C C 177.52 . . 175 257 41 GLY N N 108.63 . . 176 257 41 GLY H H 8.3 . . 177 257 41 GLY CA C 42.24 . . 178 257 41 GLY HA2 H 3.97 . . 179 257 41 GLY HA3 H 5.08 . . 180 258 42 GLY N N 106.71 . . 181 258 42 GLY H H 7.53 . . 182 258 42 GLY CA C 45.22 . . 183 258 42 GLY HA2 H 4.08 . . 184 258 42 GLY HA3 H 5.33 . . 185 259 43 THR N N 114.35 . . 186 259 43 THR H H 8.83 . . 187 259 43 THR CA C 61.26 . . 188 259 43 THR HA H 5.48 . . 189 259 43 THR C C 174.53 . . 190 260 44 VAL N N 125.55 . . 191 260 44 VAL H H 8.8 . . 192 260 44 VAL CA C 59.76 . . 193 260 44 VAL HA H 5.24 . . 194 260 44 VAL C C 173.36 . . 195 261 45 LYS N N 128.79 . . 196 261 45 LYS H H 8.33 . . 197 261 45 LYS CA C 53.92 . . 198 261 45 LYS HA H 4.85 . . 199 261 45 LYS C C 173.98 . . 200 262 46 VAL N N 127.27 . . 201 262 46 VAL H H 9.22 . . 202 262 46 VAL CA C 60.3 . . 203 262 46 VAL HA H 5.01 . . 204 262 46 VAL C C 175.21 . . 205 263 47 THR N N 115.99 . . 206 263 47 THR H H 9.12 . . 207 263 47 THR CA C 59.6 . . 208 263 47 THR HA H 5.18 . . 209 263 47 THR C C 174.31 . . 210 264 48 GLY N N 108.08 . . 211 264 48 GLY H H 8.22 . . 212 264 48 GLY CA C 45.76 . . 213 264 48 GLY HA2 H 3.8 . . 214 264 48 GLY HA3 H 4.44 . . 215 265 49 ILE N N 120.04 . . 216 265 49 ILE H H 7.7 . . 217 265 49 ILE CA C 61.5 . . 218 265 49 ILE HA H 4.02 . . 219 266 50 GLY N N 120.55 . . 220 266 50 GLY H H 8.63 . . 221 266 50 GLY CA C 44.94 . . 222 266 50 GLY HA2 H 4.08 . . 223 266 50 GLY HA3 H 3.93 . . 224 267 51 ARG N N 119.04 . . 225 267 51 ARG H H 8.72 . . 226 267 51 ARG CA C 59.76 . . 227 267 51 ARG HA H 4.32 . . 228 268 52 ASN C C 176.28 . . 229 269 53 SER N N 115.16 . . 230 269 53 SER H H 7.77 . . 231 269 53 SER CA C 59.16 . . 232 269 53 SER HA H 4.52 . . 233 270 54 MET CA C 58.91 . . 234 270 54 MET C C 175.98 . . 235 271 55 GLN N N 118.29 . . 236 271 55 GLN H H 7.63 . . 237 271 55 GLN CA C 58.44 . . 238 271 55 GLN HA H 4.55 . . 239 271 55 GLN C C 178.51 . . 240 272 56 GLY N N 108.59 . . 241 272 56 GLY H H 8.41 . . 242 272 56 GLY CA C 46.55 . . 243 272 56 GLY HA2 H 3.89 . . 244 273 57 ASP N N 111.69 . . 245 273 57 ASP H H 6.66 . . 246 273 57 ASP CA C 55.41 . . 247 273 57 ASP HA H 5.23 . . 248 273 57 ASP C C 176.59 . . 249 274 58 ILE N N 117.63 . . 250 274 58 ILE H H 8.55 . . 251 274 58 ILE CA C 59.02 . . 252 274 58 ILE HA H 4.42 . . 253 274 58 ILE C C 177.63 . . 254 275 59 ARG N N 118.84 . . 255 275 59 ARG H H 7.66 . . 256 275 59 ARG CA C 58.44 . . 257 275 59 ARG HA H 4.22 . . 258 275 59 ARG C C 176.18 . . 259 276 60 PHE N N 122.28 . . 260 276 60 PHE H H 8.66 . . 261 276 60 PHE CA C 61.82 . . 262 276 60 PHE HA H 4.35 . . 263 276 60 PHE C C 176.54 . . 264 277 61 ALA N N 113.12 . . 265 277 61 ALA H H 8.5 . . 266 277 61 ALA CA C 55.22 . . 267 277 61 ALA HA H 4.31 . . 268 277 61 ALA C C 178.2 . . 269 278 62 ASP N N 116.91 . . 270 278 62 ASP H H 8.15 . . 271 278 62 ASP CA C 56.9 . . 272 278 62 ASP HA H 4.39 . . 273 278 62 ASP C C 178.4 . . 274 279 63 VAL N N 119.95 . . 275 279 63 VAL H H 7.37 . . 276 279 63 VAL CA C 66.4 . . 277 279 63 VAL HA H 3.48 . . 278 279 63 VAL C C 178.01 . . 279 280 64 LEU N N 116.97 . . 280 280 64 LEU H H 6.93 . . 281 280 64 LEU CA C 57.22 . . 282 280 64 LEU HA H 3.75 . . 283 280 64 LEU C C 179.57 . . 284 281 65 GLU N N 120.95 . . 285 281 65 GLU H H 8.33 . . 286 281 65 GLU CA C 58.74 . . 287 281 65 GLU HA H 4.06 . . 288 281 65 GLU C C 181.07 . . 289 282 66 LYS N N 122.41 . . 290 282 66 LYS H H 8.01 . . 291 282 66 LYS CA C 58.6 . . 292 282 66 LYS HA H 4.21 . . 293 282 66 LYS C C 179.18 . . 294 283 67 MET N N 117.39 . . 295 283 67 MET H H 7.95 . . 296 283 67 MET CA C 57.84 . . 297 283 67 MET HA H 4.06 . . 298 283 67 MET C C 175.61 . . 299 284 68 GLY N N 103.67 . . 300 284 68 GLY H H 7.65 . . 301 284 68 GLY CA C 44.94 . . 302 284 68 GLY HA2 H 3.62 . . 303 284 68 GLY HA3 H 4.61 . . 304 285 69 ALA N N 126.43 . . 305 285 69 ALA H H 8.15 . . 306 285 69 ALA CA C 51.72 . . 307 285 69 ALA HA H 4.54 . . 308 285 69 ALA C C 176.58 . . 309 286 70 THR N N 115.43 . . 310 286 70 THR H H 8.15 . . 311 286 70 THR CA C 62.13 . . 312 286 70 THR HA H 4.65 . . 313 286 70 THR C C 174.02 . . 314 287 71 ILE N N 128.43 . . 315 287 71 ILE H H 9.04 . . 316 287 71 ILE CA C 56.93 . . 317 287 71 ILE HA H 5.25 . . 318 288 72 CYS N N 122.83 . . 319 288 72 CYS H H 8.66 . . 320 288 72 CYS CA C 56.97 . . 321 288 72 CYS HA H 4.67 . . 322 288 72 CYS C C 172.17 . . 323 289 73 TRP N N 120.97 . . 324 289 73 TRP H H 8.38 . . 325 289 73 TRP CA C 56.03 . . 326 289 73 TRP HA H 4.65 . . 327 289 73 TRP C C 174.66 . . 328 290 74 GLY N N 109.22 . . 329 290 74 GLY H H 7.32 . . 330 290 74 GLY CA C 43.37 . . 331 290 74 GLY HA2 H 3.89 . . 332 290 74 GLY HA3 H 4.25 . . 333 291 75 ASP N N 120.54 . . 334 291 75 ASP H H 8.74 . . 335 291 75 ASP CA C 57.06 . . 336 291 75 ASP HA H 4.41 . . 337 291 75 ASP C C 177.33 . . 338 292 76 ASP N N 115.27 . . 339 292 76 ASP H H 7.87 . . 340 292 76 ASP CA C 52.63 . . 341 292 76 ASP HA H 4.78 . . 342 292 76 ASP C C 174.81 . . 343 293 77 THR N N 113.32 . . 344 293 77 THR H H 6.97 . . 345 293 77 THR CA C 55.78 . . 346 293 77 THR HA H 5.2 . . 347 293 77 THR C C 172.97 . . 348 294 78 ILE N N 117.65 . . 349 294 78 ILE H H 8.49 . . 350 294 78 ILE CA C 60.77 . . 351 294 78 ILE HA H 4.53 . . 352 294 78 ILE C C 174.02 . . 353 295 79 SER N N 121.63 . . 354 295 79 SER H H 9.59 . . 355 295 79 SER CA C 55.6 . . 356 295 79 SER HA H 5.73 . . 357 295 79 SER C C 172.33 . . 358 296 80 CYS N N 123.3 . . 359 296 80 CYS H H 8.81 . . 360 296 80 CYS CA C 55.56 . . 361 296 80 CYS HA H 5.46 . . 362 296 80 CYS C C 172.05 . . 363 297 81 THR N N 126.56 . . 364 297 81 THR H H 9.19 . . 365 297 81 THR CA C 60.75 . . 366 297 81 THR HA H 5.26 . . 367 297 81 THR C C 172.68 . . 368 298 82 ARG N N 126.1 . . 369 298 82 ARG H H 7.45 . . 370 298 82 ARG CA C 57.72 . . 371 298 82 ARG HA H 4.78 . . 372 298 82 ARG C C 176.68 . . 373 299 83 GLY N N 119.93 . . 374 299 83 GLY H H 9.75 . . 375 299 83 GLY CA C 46.28 . . 376 299 83 GLY HA2 H 3.81 . . 377 299 83 GLY HA3 H 4.35 . . 378 300 84 GLU N N 127.24 . . 379 300 84 GLU H H 7.94 . . 380 300 84 GLU CA C 54.7 . . 381 300 84 GLU HA H 4.51 . . 382 300 84 GLU C C 174.7 . . 383 301 85 LEU N N 121.21 . . 384 301 85 LEU H H 8.59 . . 385 301 85 LEU CA C 54.76 . . 386 301 85 LEU HA H 4.74 . . 387 301 85 LEU C C 174.18 . . 388 302 86 ASN N N 127.78 . . 389 302 86 ASN H H 10.18 . . 390 302 86 ASN CA C 52.34 . . 391 302 86 ASN HA H 5.05 . . 392 302 86 ASN C C 172.78 . . 393 303 87 ALA N N 119.22 . . 394 303 87 ALA H H 7.81 . . 395 303 87 ALA CA C 52.23 . . 396 303 87 ALA HA H 4.98 . . 397 303 87 ALA C C 177.04 . . 398 304 88 ILE N N 111.05 . . 399 304 88 ILE H H 6.86 . . 400 304 88 ILE CA C 58.06 . . 401 304 88 ILE HA H 4.66 . . 402 304 88 ILE C C 173.17 . . 403 305 89 ASP N N 120.83 . . 404 305 89 ASP H H 8.01 . . 405 305 89 ASP CA C 52.31 . . 406 305 89 ASP HA H 5.67 . . 407 305 89 ASP C C 175.56 . . 408 306 90 MET N N 120 . . 409 306 90 MET H H 8.23 . . 410 306 90 MET CA C 54.66 . . 411 306 90 MET HA H 4.77 . . 412 306 90 MET C C 173.94 . . 413 307 91 ASP N N 124.18 . . 414 307 91 ASP H H 8.47 . . 415 307 91 ASP CA C 53.79 . . 416 307 91 ASP HA H 4.88 . . 417 307 91 ASP C C 176.6 . . 418 308 92 MET N N 123.47 . . 419 308 92 MET H H 8.53 . . 420 308 92 MET CA C 52.91 . . 421 308 92 MET HA H 4.25 . . 422 308 92 MET C C 177.72 . . 423 309 93 ASN N N 119.38 . . 424 309 93 ASN H H 8.97 . . 425 309 93 ASN CA C 57.31 . . 426 309 93 ASN HA H 5.06 . . 427 312 96 PRO CA C 64.86 . . 428 312 96 PRO C C 177.48 . . 429 313 97 ASP N N 115.49 . . 430 313 97 ASP H H 8.81 . . 431 313 97 ASP CA C 54.46 . . 432 313 97 ASP HA H 4.64 . . 433 313 97 ASP C C 178.41 . . 434 314 98 ALA N N 117.52 . . 435 314 98 ALA H H 7.94 . . 436 314 98 ALA CA C 54.56 . . 437 314 98 ALA HA H 4.17 . . 438 314 98 ALA C C 179.04 . . 439 315 99 ALA N N 119.15 . . 440 315 99 ALA H H 8.62 . . 441 315 99 ALA CA C 54.53 . . 442 315 99 ALA HA H 3.85 . . 443 315 99 ALA C C 178.15 . . 444 316 100 MET N N 119.54 . . 445 316 100 MET H H 8.21 . . 446 316 100 MET CA C 59.14 . . 447 316 100 MET HA H 4.42 . . 448 316 100 MET C C 176.71 . . 449 317 101 THR N N 113.98 . . 450 317 101 THR H H 7.3 . . 451 317 101 THR CA C 65.32 . . 452 317 101 THR HA H 4.04 . . 453 317 101 THR C C 176.21 . . 454 318 102 ILE N N 119.37 . . 455 318 102 ILE H H 7.31 . . 456 318 102 ILE CA C 60.97 . . 457 318 102 ILE HA H 3.7 . . 458 318 102 ILE C C 176.33 . . 459 319 103 ALA N N 120.65 . . 460 319 103 ALA H H 7.72 . . 461 319 103 ALA CA C 55 . . 462 319 103 ALA HA H 3.8 . . 463 319 103 ALA C C 176.39 . . 464 320 104 THR N N 102.42 . . 465 320 104 THR H H 6.94 . . 466 320 104 THR CA C 64.24 . . 467 320 104 THR HA H 4.14 . . 468 320 104 THR C C 178.07 . . 469 321 105 ALA N N 124.41 . . 470 321 105 ALA H H 8.31 . . 471 321 105 ALA CA C 54.77 . . 472 321 105 ALA HA H 3.75 . . 473 321 105 ALA C C 178.89 . . 474 322 106 ALA N N 116.64 . . 475 322 106 ALA H H 8.35 . . 476 322 106 ALA CA C 53.97 . . 477 322 106 ALA HA H 3.69 . . 478 322 106 ALA C C 179.8 . . 479 323 107 LEU N N 115.76 . . 480 323 107 LEU H H 7.6 . . 481 323 107 LEU CA C 56.61 . . 482 323 107 LEU HA H 4.14 . . 483 323 107 LEU C C 176.02 . . 484 324 108 PHE N N 114.31 . . 485 324 108 PHE H H 7.94 . . 486 324 108 PHE CA C 56.98 . . 487 324 108 PHE HA H 4.46 . . 488 324 108 PHE C C 174.84 . . 489 325 109 ALA N N 123.59 . . 490 325 109 ALA H H 7.23 . . 491 325 109 ALA CA C 49.94 . . 492 325 109 ALA HA H 4.52 . . 493 325 109 ALA C C 175.81 . . 494 326 110 LYS N N 118.88 . . 495 326 110 LYS H H 8.23 . . 496 326 110 LYS CA C 55.89 . . 497 326 110 LYS HA H 4.54 . . 498 326 110 LYS C C 176.58 . . 499 327 111 GLY N N 116.97 . . 500 327 111 GLY H H 8.53 . . 501 327 111 GLY CA C 43.49 . . 502 327 111 GLY HA2 H 3.76 . . 503 327 111 GLY HA3 H 4.42 . . 504 328 112 THR N N 116.03 . . 505 328 112 THR H H 8.23 . . 506 328 112 THR CA C 62.92 . . 507 328 112 THR HA H 4.8 . . 508 328 112 THR C C 174.87 . . 509 329 113 THR N N 131.03 . . 510 329 113 THR H H 8.82 . . 511 329 113 THR CA C 62.9 . . 512 329 113 THR HA H 4.99 . . 513 329 113 THR C C 173.86 . . 514 330 114 THR N N 123.57 . . 515 330 114 THR H H 9.21 . . 516 330 114 THR CA C 61.99 . . 517 330 114 THR HA H 5.13 . . 518 330 114 THR C C 172.09 . . 519 331 115 LEU N N 124.39 . . 520 331 115 LEU H H 8.64 . . 521 331 115 LEU CA C 52.53 . . 522 331 115 LEU HA H 5.02 . . 523 331 115 LEU C C 175.1 . . 524 332 116 ARG N N 119.2 . . 525 332 116 ARG H H 8.35 . . 526 332 116 ARG CA C 54.16 . . 527 332 116 ARG HA H 4.38 . . 528 332 116 ARG C C 175.6 . . 529 333 117 ASN N N 120.64 . . 530 333 117 ASN H H 8.89 . . 531 333 117 ASN CA C 52.82 . . 532 333 117 ASN HA H 5.22 . . 533 333 117 ASN C C 175.43 . . 534 334 118 ILE N N 109.21 . . 535 334 118 ILE H H 7.85 . . 536 334 118 ILE CA C 59.83 . . 537 334 118 ILE HA H 4.37 . . 538 334 118 ILE C C 177.28 . . 539 335 119 THR N N 123.49 . . 540 335 119 THR H H 8.07 . . 541 335 119 THR CA C 56.52 . . 542 335 119 THR HA H 4.16 . . 543 335 119 THR C C 174.72 . . 544 336 120 ASN N N 113.53 . . 545 336 120 ASN H H 9.35 . . 546 336 120 ASN CA C 54.12 . . 547 336 120 ASN HA H 4.54 . . 548 337 121 TRP CA C 59.82 . . 549 337 121 TRP C C 176.74 . . 550 338 122 ARG N N 122.74 . . 551 338 122 ARG H H 8.14 . . 552 338 122 ARG CA C 56.06 . . 553 338 122 ARG HA H 4.15 . . 554 338 122 ARG C C 177.65 . . 555 339 123 VAL N N 120.54 . . 556 339 123 VAL H H 8.3 . . 557 339 123 VAL CA C 58.71 . . 558 339 123 VAL HA H 4.53 . . 559 339 123 VAL C C 176.3 . . 560 340 124 LYS N N 114.89 . . 561 340 124 LYS H H 8.49 . . 562 340 124 LYS CA C 57.96 . . 563 340 124 LYS HA H 4.14 . . 564 340 124 LYS C C 176.87 . . 565 341 125 GLU N N 116.87 . . 566 341 125 GLU H H 8.38 . . 567 341 125 GLU CA C 58.46 . . 568 341 125 GLU HA H 3.93 . . 569 341 125 GLU C C 177.62 . . 570 342 126 THR N N 111.57 . . 571 342 126 THR H H 7.38 . . 572 342 126 THR CA C 61.02 . . 573 342 126 THR HA H 4.23 . . 574 342 126 THR C C 172.71 . . 575 343 127 ASP N N 121.47 . . 576 343 127 ASP H H 8.17 . . 577 343 127 ASP CA C 54.06 . . 578 343 127 ASP HA H 4.55 . . 579 343 127 ASP C C 177.05 . . 580 344 128 ARG N N 119.87 . . 581 344 128 ARG H H 8.19 . . 582 344 128 ARG CA C 59.14 . . 583 344 128 ARG HA H 4.33 . . 584 344 128 ARG C C 176.09 . . 585 345 129 LEU N N 114.75 . . 586 345 129 LEU H H 6.95 . . 587 345 129 LEU CA C 58.36 . . 588 345 129 LEU HA H 4.24 . . 589 346 130 PHE N N 119.91 . . 590 346 130 PHE H H 7.97 . . 591 346 130 PHE CA C 61.2 . . 592 346 130 PHE HA H 4.49 . . 593 346 130 PHE C C 179.07 . . 594 347 131 ALA N N 123.07 . . 595 347 131 ALA H H 8.12 . . 596 347 131 ALA CA C 55.1 . . 597 347 131 ALA HA H 4.15 . . 598 347 131 ALA C C 178.69 . . 599 348 132 MET N N 115.02 . . 600 348 132 MET H H 8.27 . . 601 348 132 MET CA C 57.80 . . 602 348 132 MET HA H 4.2 . . 603 348 132 MET C C 178.15 . . 604 349 133 ALA N N 118.99 . . 605 349 133 ALA H H 8.22 . . 606 349 133 ALA CA C 55.89 . . 607 349 133 ALA HA H 4.42 . . 608 350 134 THR N N 112.41 . . 609 350 134 THR H H 7.7 . . 610 350 134 THR CA C 66.57 . . 611 350 134 THR HA H 4.18 . . 612 350 134 THR C C 177.32 . . 613 351 135 GLU N N 119.53 . . 614 351 135 GLU H H 8.08 . . 615 351 135 GLU CA C 58.29 . . 616 351 135 GLU HA H 4.18 . . 617 351 135 GLU C C 178.86 . . 618 352 136 LEU N N 117.87 . . 619 352 136 LEU H H 8.87 . . 620 352 136 LEU CA C 57.54 . . 621 352 136 LEU HA H 3.18 . . 622 352 136 LEU C C 180.21 . . 623 353 137 ARG N N 116.33 . . 624 353 137 ARG H H 7.75 . . 625 353 137 ARG CA C 58.89 . . 626 353 137 ARG HA H 4 . . 627 353 137 ARG C C 181.37 . . 628 354 138 LYS N N 119.23 . . 629 354 138 LYS H H 7.44 . . 630 354 138 LYS CA C 59.5 . . 631 354 138 LYS HA H 4.41 . . 632 354 138 LYS C C 179.66 . . 633 355 139 VAL N N 109.6 . . 634 355 139 VAL H H 7.11 . . 635 355 139 VAL CA C 61.89 . . 636 355 139 VAL HA H 4 . . 637 355 139 VAL C C 175.46 . . 638 356 140 GLY N N 105.6 . . 639 356 140 GLY H H 7.58 . . 640 356 140 GLY CA C 44.22 . . 641 356 140 GLY HA2 H 3.62 . . 642 356 140 GLY HA3 H 4.56 . . 643 357 141 ALA N N 120.47 . . 644 357 141 ALA H H 7.3 . . 645 357 141 ALA CA C 51.97 . . 646 357 141 ALA HA H 4.13 . . 647 357 141 ALA C C 176.15 . . 648 358 142 GLU N N 122.29 . . 649 358 142 GLU H H 8.22 . . 650 358 142 GLU CA C 55.26 . . 651 358 142 GLU HA H 5.35 . . 652 358 142 GLU C C 175.79 . . 653 359 143 VAL N N 126.97 . . 654 359 143 VAL H H 9.06 . . 655 359 143 VAL CA C 59.81 . . 656 359 143 VAL HA H 5.16 . . 657 359 143 VAL C C 175.31 . . 658 360 144 GLU N N 129.71 . . 659 360 144 GLU H H 9.09 . . 660 360 144 GLU CA C 54.13 . . 661 360 144 GLU HA H 4.62 . . 662 360 144 GLU C C 174.17 . . 663 361 145 GLU N N 128.2 . . 664 361 145 GLU H H 8.96 . . 665 361 145 GLU CA C 54.65 . . 666 361 145 GLU HA H 4.99 . . 667 361 145 GLU C C 175.34 . . 668 362 146 GLY N N 114.11 . . 669 362 146 GLY H H 7.56 . . 670 362 146 GLY CA C 42.18 . . 671 362 146 GLY HA2 H 4.01 . . 672 362 146 GLY HA3 H 4.03 . . 673 363 147 HIS N N 119.08 . . 674 363 147 HIS H H 8.73 . . 675 363 147 HIS CA C 58.01 . . 676 363 147 HIS HA H 4.09 . . 677 363 147 HIS C C 173.08 . . 678 364 148 ASP N N 119.16 . . 679 364 148 ASP H H 8.74 . . 680 364 148 ASP CA C 59.76 . . 681 364 148 ASP HA H 4.78 . . 682 364 148 ASP C C 175.9 . . 683 365 149 THR N N 128.04 . . 684 365 149 THR H H 8.29 . . 685 365 149 THR CA C 52.83 . . 686 365 149 THR HA H 4.54 . . 687 365 149 THR C C 176.4 . . 688 366 150 ILE N N 124.14 . . 689 366 150 ILE H H 8.54 . . 690 366 150 ILE CA C 58.94 . . 691 366 150 ILE HA H 4.97 . . 692 366 150 ILE C C 171.76 . . 693 367 151 ARG N N 127.3 . . 694 367 151 ARG H H 8.69 . . 695 367 151 ARG CA C 54.33 . . 696 367 151 ARG HA H 5.58 . . 697 367 151 ARG C C 175.42 . . 698 368 152 ILE N N 126.62 . . 699 368 152 ILE H H 9.67 . . 700 368 152 ILE CA C 61.13 . . 701 368 152 ILE HA H 4.38 . . 702 368 152 ILE C C 173.51 . . 703 369 153 THR N N 125 . . 704 369 153 THR H H 9.14 . . 705 369 153 THR CA C 59.18 . . 706 369 153 THR HA H 5.16 . . 707 369 153 THR C C 174.53 . . 708 371 155 PRO CA C 61.17 . . 709 371 155 PRO HA H 4.01 . . 710 371 155 PRO C C 176.23 . . 711 372 156 GLU N N 120.12 . . 712 372 156 GLU H H 8.7 . . 713 372 156 GLU CA C 58.16 . . 714 372 156 GLU HA H 4.77 . . 715 372 156 GLU C C 176.69 . . 716 373 157 LYS N N 116.08 . . 717 373 157 LYS H H 7.57 . . 718 373 157 LYS CA C 54.21 . . 719 373 157 LYS HA H 4.56 . . 720 373 157 LYS C C 174.91 . . 721 374 158 LEU N N 125.09 . . 722 374 158 LEU H H 8.76 . . 723 374 158 LEU CA C 55.04 . . 724 374 158 LEU HA H 4.49 . . 725 374 158 LEU C C 176.81 . . 726 375 159 ASN N N 117.64 . . 727 375 159 ASN H H 8.23 . . 728 375 159 ASN CA C 51.33 . . 729 375 159 ASN HA H 4.91 . . 730 375 159 ASN C C 174.51 . . 731 376 160 PHE N N 121.02 . . 732 376 160 PHE H H 8.49 . . 733 376 160 PHE CA C 56.11 . . 734 376 160 PHE HA H 4.78 . . 735 376 160 PHE C C 174.19 . . 736 377 161 ALA N N 133.92 . . 737 377 161 ALA H H 9.03 . . 738 377 161 ALA CA C 50.21 . . 739 377 161 ALA HA H 4.25 . . 740 377 161 ALA C C 173.51 . . 741 378 162 GLU N N 116.71 . . 742 378 162 GLU H H 7.72 . . 743 378 162 GLU CA C 53.91 . . 744 378 162 GLU HA H 4.55 . . 745 378 162 GLU C C 174.72 . . 746 379 163 ILE N N 125.56 . . 747 379 163 ILE H H 8.96 . . 748 379 163 ILE CA C 56.86 . . 749 379 163 ILE HA H 4.77 . . 750 379 163 ILE C C 175.49 . . 751 380 164 ALA N N 131.26 . . 752 380 164 ALA H H 7.95 . . 753 380 164 ALA CA C 51.04 . . 754 380 164 ALA HA H 4.15 . . 755 380 164 ALA C C 176.23 . . 756 381 165 THR N N 102.3 . . 757 381 165 THR H H 7.45 . . 758 381 165 THR CA C 59.76 . . 759 381 165 THR HA H 4.14 . . 760 381 165 THR C C 176.43 . . 761 382 166 THR N N 115.72 . . 762 382 166 THR H H 7.67 . . 763 382 166 THR CA C 58.76 . . 764 382 166 THR HA H 4.2 . . 765 382 166 THR C C 174.72 . . 766 383 167 ASN N N 113.34 . . 767 383 167 ASN H H 9.32 . . 768 383 167 ASN CA C 54.11 . . 769 383 167 ASN HA H 4.21 . . 770 383 167 ASN C C 174.4 . . 771 384 168 ASP N N 119.07 . . 772 384 168 ASP H H 8.45 . . 773 384 168 ASP CA C 52.71 . . 774 384 168 ASP HA H 4.54 . . 775 384 168 ASP C C 178.98 . . 776 385 169 HIS N N 123.16 . . 777 385 169 HIS H H 8.01 . . 778 385 169 HIS CA C 52.09 . . 779 385 169 HIS HA H 4.46 . . 780 385 169 HIS C C 177.86 . . 781 386 170 ARG N N 116.46 . . 782 386 170 ARG H H 8.84 . . 783 386 170 ARG CA C 58.29 . . 784 386 170 ARG HA H 4.4 . . 785 386 170 ARG C C 179.89 . . 786 387 171 MET N N 116.48 . . 787 387 171 MET H H 7.44 . . 788 387 171 MET CA C 56.56 . . 789 387 171 MET HA H 4.39 . . 790 387 171 MET C C 178.17 . . 791 388 172 ALA N N 118.68 . . 792 388 172 ALA H H 6.75 . . 793 388 172 ALA CA C 54.73 . . 794 388 172 ALA HA H 3.84 . . 795 388 172 ALA C C 177.66 . . 796 389 173 MET N N 113.43 . . 797 389 173 MET H H 7.37 . . 798 389 173 MET CA C 58.78 . . 799 389 173 MET HA H 3.03 . . 800 389 173 MET C C 179.34 . . 801 390 174 CYS N N 118.25 . . 802 390 174 CYS H H 8.66 . . 803 390 174 CYS CA C 64.6 . . 804 390 174 CYS HA H 4.01 . . 805 390 174 CYS C C 177.36 . . 806 391 175 PHE N N 115.42 . . 807 391 175 PHE H H 7.82 . . 808 391 175 PHE CA C 62.36 . . 809 391 175 PHE HA H 4.14 . . 810 391 175 PHE C C 177.34 . . 811 392 176 SER N N 116.29 . . 812 392 176 SER H H 7.52 . . 813 392 176 SER CA C 61.8 . . 814 392 176 SER HA H 4.03 . . 815 392 176 SER C C 173.66 . . 816 393 177 LEU N N 115.08 . . 817 393 177 LEU H H 6.91 . . 818 393 177 LEU CA C 55.49 . . 819 393 177 LEU HA H 3.88 . . 820 393 177 LEU C C 178.26 . . 821 394 178 VAL N N 116.85 . . 822 394 178 VAL H H 7.67 . . 823 394 178 VAL CA C 66.1 . . 824 394 178 VAL HA H 3.63 . . 825 394 178 VAL C C 176.04 . . 826 395 179 ALA N N 117.93 . . 827 395 179 ALA H H 7.14 . . 828 395 179 ALA CA C 52.77 . . 829 395 179 ALA HA H 3.89 . . 830 395 179 ALA C C 175.92 . . 831 396 180 LEU N N 119 . . 832 396 180 LEU H H 7.6 . . 833 396 180 LEU CA C 53.84 . . 834 396 180 LEU HA H 4.56 . . 835 396 180 LEU C C 176.37 . . 836 397 181 SER N N 115.64 . . 837 397 181 SER H H 8.34 . . 838 397 181 SER CA C 58.06 . . 839 397 181 SER HA H 4.37 . . 840 397 181 SER C C 172.64 . . 841 398 182 ASP N N 115.29 . . 842 398 182 ASP H H 8.04 . . 843 398 182 ASP CA C 53.44 . . 844 398 182 ASP HA H 4.7 . . 845 398 182 ASP C C 175.8 . . 846 399 183 THR N N 120.92 . . 847 399 183 THR H H 9.12 . . 848 399 183 THR CA C 58.61 . . 849 399 183 THR HA H 5.78 . . 850 400 184 PRO CA C 61.02 . . 851 400 184 PRO HA H 4.76 . . 852 400 184 PRO C C 175.4 . . 853 401 185 VAL N N 114.07 . . 854 401 185 VAL H H 8.03 . . 855 401 185 VAL CA C 60.36 . . 856 401 185 VAL HA H 4.75 . . 857 401 185 VAL C C 172.03 . . 858 402 186 THR N N 125.14 . . 859 402 186 THR H H 8.24 . . 860 402 186 THR CA C 61.32 . . 861 402 186 THR HA H 5.2 . . 862 402 186 THR C C 172.03 . . 863 403 187 ILE N N 128.6 . . 864 403 187 ILE H H 9.47 . . 865 403 187 ILE CA C 58.2 . . 866 403 187 ILE HA H 4.1 . . 867 403 187 ILE C C 175.38 . . 868 404 188 LEU N N 127.51 . . 869 404 188 LEU H H 8.57 . . 870 404 188 LEU CA C 54.54 . . 871 404 188 LEU HA H 4.44 . . 872 404 188 LEU C C 176.39 . . 873 405 189 ASP N N 116.83 . . 874 405 189 ASP H H 8.61 . . 875 405 189 ASP CA C 54.16 . . 876 405 189 ASP HA H 4.97 . . 877 405 189 ASP C C 176.33 . . 878 406 190 PRO CA C 64.52 . . 879 406 190 PRO HA H 4.45 . . 880 406 190 PRO C C 177.7 . . 881 407 191 LYS N N 118.8 . . 882 407 191 LYS H H 8.77 . . 883 407 191 LYS CA C 57.95 . . 884 407 191 LYS HA H 4.33 . . 885 407 191 LYS C C 174.68 . . 886 408 192 CYS N N 120.58 . . 887 408 192 CYS H H 8.29 . . 888 408 192 CYS CA C 60.77 . . 889 408 192 CYS HA H 4.63 . . 890 408 192 CYS C C 176.69 . . 891 409 193 THR N N 111.91 . . 892 409 193 THR H H 7.75 . . 893 409 193 THR CA C 63.39 . . 894 409 193 THR HA H 4.31 . . 895 409 193 THR C C 175.58 . . 896 410 194 ALA N N 123.31 . . 897 410 194 ALA H H 7.9 . . 898 410 194 ALA CA C 55.46 . . 899 410 194 ALA HA H 4.16 . . 900 410 194 ALA C C 177.97 . . 901 411 195 LYS N N 114.31 . . 902 411 195 LYS H H 7.76 . . 903 411 195 LYS CA C 57.65 . . 904 411 195 LYS HA H 4.14 . . 905 411 195 LYS C C 177.38 . . 906 412 196 THR N N 109.24 . . 907 412 196 THR H H 7.46 . . 908 412 196 THR CA C 62.31 . . 909 412 196 THR HA H 4.14 . . 910 412 196 THR C C 176.85 . . 911 413 197 PHE N N 120.91 . . 912 413 197 PHE H H 8.25 . . 913 413 197 PHE CA C 62.28 . . 914 413 197 PHE HA H 4.63 . . 915 414 198 PRO CA C 64.82 . . 916 414 198 PRO HA H 4.27 . . 917 414 198 PRO C C 177.48 . . 918 415 199 ASP N N 115.23 . . 919 415 199 ASP H H 8.85 . . 920 415 199 ASP CA C 52.74 . . 921 415 199 ASP HA H 3.36 . . 922 415 199 ASP C C 176.09 . . 923 416 200 THR N N 120.32 . . 924 416 200 THR H H 7.53 . . 925 416 200 THR CA C 63.03 . . 926 416 200 THR HA H 4.09 . . 927 416 200 THR C C 175.9 . . 928 417 201 PHE N N 113.99 . . 929 417 201 PHE H H 8.1 . . 930 417 201 PHE CA C 62.25 . . 931 417 201 PHE HA H 3.72 . . 932 417 201 PHE C C 179.14 . . 933 418 202 GLU N N 122.23 . . 934 418 202 GLU H H 8.06 . . 935 418 202 GLU CA C 59.29 . . 936 418 202 GLU HA H 4.09 . . 937 418 202 GLU C C 179.49 . . 938 419 203 GLN N N 120.4 . . 939 419 203 GLN H H 8.32 . . 940 419 203 GLN CA C 58.71 . . 941 419 203 GLN HA H 3.72 . . 942 419 203 GLN C C 178.16 . . 943 420 204 LEU N N 118.48 . . 944 420 204 LEU H H 8.12 . . 945 420 204 LEU CA C 57.16 . . 946 420 204 LEU HA H 3.92 . . 947 420 204 LEU C C 179.57 . . 948 421 205 ALA N N 120.69 . . 949 421 205 ALA H H 7.91 . . 950 421 205 ALA CA C 54.67 . . 951 421 205 ALA HA H 3.97 . . 952 421 205 ALA C C 180.6 . . 953 422 206 ARG N N 117.76 . . 954 422 206 ARG H H 7.74 . . 955 422 206 ARG CA C 58.88 . . 956 422 206 ARG HA H 4.12 . . 957 422 206 ARG C C 178.61 . . 958 423 207 ILE N N 108.16 . . 959 423 207 ILE H H 7.29 . . 960 423 207 ILE CA C 61.11 . . 961 423 207 ILE HA H 4.61 . . 962 423 207 ILE C C 175.16 . . 963 424 208 SER N N 118.45 . . 964 424 208 SER H H 7.36 . . 965 424 208 SER CA C 59.45 . . 966 424 208 SER HA H 4.02 . . 967 424 208 SER C C 173.32 . . 968 425 209 GLN N N 122.72 . . 969 425 209 GLN H H 8.6 . . 970 425 209 GLN CA C 53.58 . . 971 425 209 GLN HA H 4.26 . . 972 425 209 GLN C C 175.27 . . 973 426 210 ALA N N 126.33 . . 974 426 210 ALA H H 8.6 . . 975 426 210 ALA CA C 52.43 . . 976 426 210 ALA HA H 4.31 . . 977 426 210 ALA C C 176.78 . . 978 427 211 ALA N N 127.52 . . 979 427 211 ALA H H 8 . . 980 427 211 ALA CA C 53.56 . . 981 427 211 ALA HA H 3.98 . . 982 427 211 ALA C C 182.31 . . stop_ save_