data_6163 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; Backbone 1H, 13C, 15N assignment of the bHLHZip domain of the oncogenic transcription factor v-myc in complex with its authentic binding partner max ; _BMRB_accession_number 6163 _BMRB_flat_file_name bmr6163.str _Entry_type original _Submission_date 2004-04-02 _Accession_date 2004-04-02 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Baminger Bettina . . 2 Ludwiczek Martin L. . 3 Hoffmann Bernd . . 4 Kontaxis Georg . . 5 Bister Klaus . . 6 Konrat Robert . . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 88 "13C chemical shifts" 95 "15N chemical shifts" 88 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2004-12-16 original author . stop_ _Original_release_date 2004-12-16 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title 'Letter to the editor: Backbone assignment of the dimerization and DNA-binding domain of the oncogenic transcription factor v-Myc in complex with its authentic binding partner Max' _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID ? loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Baminger Bettina . . 2 Ludwiczek Martin L. . 3 Hoffmann Bernd . . 4 Kontaxis Georg . . 5 Bister Klaus . . 6 Konrat Robert . . stop_ _Journal_abbreviation 'J. Biomol. NMR' _Journal_volume 30 _Journal_issue 3 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 361 _Page_last 362 _Year 2004 _Details . loop_ _Keyword v-myc 'oncogenic transcription factor' '4-helix bundle' stop_ save_ ################################## # Molecular system description # ################################## save_system_v-myc_max _Saveframe_category molecular_system _Mol_system_name 'v-myc/max heterodimer' _Abbreviation_common v-myc/max _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label v-myc $v-myc max $max stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state dimer _System_paramagnetic no _System_thiol_state 'all free' loop_ _Biological_function 'transcription factor' stop_ _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_v-myc _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common v-myc _Abbreviation_common v-myc _Molecular_mass 12357 _Mol_thiol_state 'all free' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 103 _Mol_residue_sequence ; SNNRKCSSPRTLDSEENDKR RTHNVLERQRRNELKLRFFA LRDQIPEVANNEKAPKVVIL KKATEYVLSLQSDEHKLIAE KEQLRRRREQLKHNLEQLRN SRA ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 314 SER 2 315 ASN 3 316 ASN 4 317 ARG 5 318 LYS 6 319 CYS 7 320 SER 8 321 SER 9 322 PRO 10 323 ARG 11 324 THR 12 325 LEU 13 326 ASP 14 327 SER 15 328 GLU 16 329 GLU 17 330 ASN 18 331 ASP 19 332 LYS 20 333 ARG 21 334 ARG 22 335 THR 23 336 HIS 24 337 ASN 25 338 VAL 26 339 LEU 27 340 GLU 28 341 ARG 29 342 GLN 30 343 ARG 31 344 ARG 32 345 ASN 33 346 GLU 34 347 LEU 35 348 LYS 36 349 LEU 37 350 ARG 38 351 PHE 39 352 PHE 40 353 ALA 41 354 LEU 42 355 ARG 43 356 ASP 44 357 GLN 45 358 ILE 46 359 PRO 47 360 GLU 48 361 VAL 49 362 ALA 50 363 ASN 51 364 ASN 52 365 GLU 53 366 LYS 54 367 ALA 55 368 PRO 56 369 LYS 57 370 VAL 58 371 VAL 59 372 ILE 60 373 LEU 61 374 LYS 62 375 LYS 63 376 ALA 64 377 THR 65 378 GLU 66 379 TYR 67 380 VAL 68 381 LEU 69 382 SER 70 383 LEU 71 384 GLN 72 385 SER 73 386 ASP 74 387 GLU 75 388 HIS 76 389 LYS 77 390 LEU 78 391 ILE 79 392 ALA 80 393 GLU 81 394 LYS 82 395 GLU 83 396 GLN 84 397 LEU 85 398 ARG 86 399 ARG 87 400 ARG 88 401 ARG 89 402 GLU 90 403 GLN 91 404 LEU 92 405 LYS 93 406 HIS 94 407 ASN 95 408 LEU 96 409 GLU 97 410 GLN 98 411 LEU 99 412 ARG 100 413 ASN 101 414 SER 102 415 ARG 103 416 ALA stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2014-10-19 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value PDB 1AN2 "Recognition By Max Of Its Cognate Dna Through A Dimeric B/hlh/z Domain" 92.47 86 98.84 98.84 1.58e-51 PDB 1HLO "The Crystal Structure Of An Intact Human Max-Dna Complex: New Insights Into Mechanisms Of Transcriptional Control" 76.34 80 98.59 98.59 4.28e-41 PDB 1NKP "Crystal Structure Of Myc-Max Recognizing Dna" 86.02 83 98.75 98.75 1.99e-47 PDB 1NLW "Crystal Structure Of Mad-Max Recognizing Dna" 81.72 76 98.68 98.68 1.18e-44 DBJ BAA03337 "Max [Rattus norvegicus]" 98.92 160 97.83 97.83 2.11e-55 DBJ BAA03338 "Max [Rattus norvegicus]" 98.92 151 97.83 97.83 1.97e-55 DBJ BAA07038 "Max [Felis catus]" 98.92 160 97.83 97.83 2.07e-55 DBJ BAC37914 "unnamed protein product [Mus musculus]" 98.92 151 97.83 97.83 2.06e-55 DBJ BAE00858 "unnamed protein product [Macaca fascicularis]" 98.92 151 97.83 97.83 1.83e-55 EMBL CAA42827 "max [Homo sapiens]" 82.80 103 98.70 98.70 1.44e-45 EMBL CAA47337 "max [Homo sapiens]" 98.92 160 97.83 97.83 2.07e-55 EMBL CAA47338 "max [Homo sapiens]" 82.80 103 98.70 98.70 1.44e-45 EMBL CAA47339 "max [Homo sapiens]" 82.80 134 98.70 98.70 8.56e-46 EMBL CAG46988 "MAX [Homo sapiens]" 82.80 94 98.70 98.70 1.75e-45 GB AAA16834 "max [Gallus gallus]" 98.92 160 98.91 98.91 5.37e-56 GB AAA36200 "helix-loop-helix zipper protein [Homo sapiens]" 98.92 151 97.83 97.83 1.83e-55 GB AAA36201 "helix-loop-helix zipper protein [Homo sapiens]" 98.92 160 97.83 97.83 2.07e-55 GB AAB35748 "dMax [Mus sp.]" 60.22 124 98.21 98.21 5.28e-29 GB AAH03525 "MYC associated factor X [Homo sapiens]" 98.92 151 97.83 97.83 1.83e-55 REF NP_001009866 "protein max [Felis catus]" 98.92 160 97.83 97.83 2.07e-55 REF NP_001139648 "protein max isoform 2 [Mus musculus]" 98.92 151 97.83 97.83 2.06e-55 REF NP_001248298 "protein max [Macaca mulatta]" 98.92 151 97.83 97.83 1.83e-55 REF NP_001272145 "uncharacterized protein LOC101866471 [Macaca fascicularis]" 98.92 151 97.83 97.83 1.83e-55 REF NP_002373 "protein max isoform a [Homo sapiens]" 98.92 160 97.83 97.83 2.07e-55 SP P52162 "RecName: Full=Protein max; AltName: Full=Myc-associated factor X [Gallus gallus]" 98.92 160 98.91 98.91 5.37e-56 SP P52164 "RecName: Full=Protein max; AltName: Full=Myc-associated factor X [Rattus norvegicus]" 98.92 160 97.83 97.83 2.11e-55 SP P61244 "RecName: Full=Protein max; AltName: Full=Class D basic helix-loop-helix protein 4; Short=bHLHd4; AltName: Full=Myc-associated f" 98.92 160 97.83 97.83 2.07e-55 SP P61245 "RecName: Full=Protein max; AltName: Full=Myc-associated factor X [Felis catus]" 98.92 160 97.83 97.83 2.07e-55 stop_ save_ save_max _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common max _Abbreviation_common max _Molecular_mass 10927 _Mol_thiol_state 'all free' _Details . _Residue_count 93 _Mol_residue_sequence ; MADKRAHHNALERKRRDHIK DSFHSLRDSVFSLQGEKASR AQILDKATEYIQYMRRKNHT HQQDIDDLKRQNALLEQQVR ALEKARSSAQLQA ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 21 MET 2 22 ALA 3 23 ASP 4 24 LYS 5 25 ARG 6 26 ALA 7 27 HIS 8 28 HIS 9 29 ASN 10 30 ALA 11 31 LEU 12 32 GLU 13 33 ARG 14 34 LYS 15 35 ARG 16 36 ARG 17 37 ASP 18 38 HIS 19 39 ILE 20 40 LYS 21 41 ASP 22 42 SER 23 43 PHE 24 44 HIS 25 45 SER 26 46 LEU 27 47 ARG 28 48 ASP 29 49 SER 30 50 VAL 31 51 PHE 32 52 SER 33 53 LEU 34 54 GLN 35 55 GLY 36 56 GLU 37 57 LYS 38 58 ALA 39 59 SER 40 60 ARG 41 61 ALA 42 62 GLN 43 63 ILE 44 64 LEU 45 65 ASP 46 66 LYS 47 67 ALA 48 68 THR 49 69 GLU 50 70 TYR 51 71 ILE 52 72 GLN 53 73 TYR 54 74 MET 55 75 ARG 56 76 ARG 57 77 LYS 58 78 ASN 59 79 HIS 60 80 THR 61 81 HIS 62 82 GLN 63 83 GLN 64 84 ASP 65 85 ILE 66 86 ASP 67 87 ASP 68 88 LEU 69 89 LYS 70 90 ARG 71 91 GLN 72 92 ASN 73 93 ALA 74 94 LEU 75 95 LEU 76 96 GLU 77 97 GLN 78 98 GLN 79 99 VAL 80 100 ARG 81 101 ALA 82 102 LEU 83 103 GLU 84 104 LYS 85 105 ALA 86 106 ARG 87 107 SER 88 108 SER 89 109 ALA 90 110 GLN 91 111 LEU 92 112 GLN 93 113 ALA stop_ _Sequence_homology_query_date 2008-08-19 _Sequence_homology_query_revised_last_date 2008-08-19 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value SWISS-PROT P52162 'Protein max (Myc-associated factor X)' 98.92 160 98.91 98.91 1.17e-44 REF XP_001514941 'PREDICTED: similar to helix-loop-helix zipper protein [Ornithorhynchus anatinus]' 98.92 258 98.91 98.91 3.31e-45 REF XP_001369712 'PREDICTED: similar to max isoform 2 [Monodelphis domestica]' 82.80 103 98.70 98.70 4.41e-36 REF XP_001103369 'PREDICTED: similar to MAX protein isoform c [Macaca mulatta]' 82.80 103 98.70 98.70 4.83e-36 REF NP_660092 'MAX protein isoform e [Homo sapiens]' 82.80 134 98.70 98.70 1.47e-36 REF NP_660088 'MAX protein isoform c [Homo sapiens]' 82.80 103 98.70 98.70 4.41e-36 GenBank EAW80899 'MYC associated factor X, isoform CRA_b [Homo sapiens]' 82.80 134 98.70 98.70 1.47e-36 GenBank AAQ57210 'MAX protein [Homo sapiens]' 82.80 94 98.70 98.70 6.26e-36 GenBank AAH36092 'MAX protein [Homo sapiens]' 82.80 134 98.70 98.70 1.76e-36 GenBank AAB35748 'dMax; variant Myc-associated factor X protein [Mus sp.]' 60.22 124 98.21 98.21 1.63e-23 GenBank AAA16834 max 98.92 160 98.91 98.91 1.17e-44 EMBL CAG46988 'MAX [Homo sapiens]' 82.80 94 98.70 98.70 6.26e-36 EMBL CAA47339 'max [Homo sapiens]' 82.80 134 98.70 98.70 1.47e-36 EMBL CAA47338 'max [Homo sapiens]' 82.80 103 98.70 98.70 4.41e-36 EMBL CAA42827 'max [Homo sapiens]' 82.80 103 98.70 98.70 4.41e-36 DBJ BAF85319 'unnamed protein product [Homo sapiens]' 82.80 134 98.70 98.70 1.47e-36 DBJ BAF83618 'unnamed protein product [Homo sapiens]' 82.80 103 98.70 98.70 4.41e-36 PDB 1NLW 'Crystal Structure Of Mad-Max Recognizing Dna' 81.72 76 98.68 98.68 3.99e-35 PDB 1NKP 'Crystal Structure Of Myc-Max Recognizing Dna' 86.02 83 98.75 98.75 2.56e-37 PDB 1HLO 'The Crystal Structure Of An Intact Human Max-Dna Complex: New Insights Into Mechanisms Of Transcriptional Control' 76.34 80 98.59 98.59 1.98e-32 PDB 1AN2 'Recognition By Max Of Its Cognate Dna Through A Dimeric BHLHZ DOMAIN' 92.47 86 98.84 98.84 1.73e-40 stop_ save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $v-myc 'E. coli' 562 Eubacteria . Escherichia coli $max 'E. coli' 562 Eubacteria . Escherichia coli stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $v-myc 'recombinant technology' 'E. coli' Escherichia coli . . $max 'recombinant technology' 'E. coli' Escherichia coli . . stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $v-myc 1.1 mM '[U-2H; U-15N; U-13C]' $max 1.1 mM . stop_ save_ ############################ # Computer software used # ############################ save_NMRView _Saveframe_category software _Name NMRView _Version 5.0.4 loop_ _Task 'analysis of NMR datasets' stop_ _Details ; NMRView: A computer program for the visualization and analysis of NMR data (1994) B. A. Johnson and R. A. Blevins, J. Biomolecular NMR 4:603-614. ; save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_NMR_spectrometer _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model Unity_Inova _Field_strength 800 _Details . save_ ############################# # NMR applied experiments # ############################# save_HNCA_1 _Saveframe_category NMR_applied_experiment _Experiment_name HNCA _Sample_label $sample_1 save_ save_HNCACB_2 _Saveframe_category NMR_applied_experiment _Experiment_name HNCACB _Sample_label $sample_1 save_ save_HNCO_3 _Saveframe_category NMR_applied_experiment _Experiment_name HNCO _Sample_label $sample_1 save_ save_1H-15N_NOESY_4 _Saveframe_category NMR_applied_experiment _Experiment_name '1H-15N NOESY' _Sample_label $sample_1 save_ ####################### # Sample conditions # ####################### save_cond_v-Myc_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 6.5 0.2 pH temperature 313 1 K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio _Indirect_shift_ratio_citation_label _Correction_value_citation_label water H 1 protons ppm 4.63 internal direct . . . 1 $entry_citation $entry_citation water C 13 protons ppm 4.63 internal indirect cylindrical internal perpendicular 0.252 $entry_citation $entry_citation water N 15 protons ppm 4.63 internal indirect cylindrical internal parallel 0.101 $entry_citation $entry_citation stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_chemical_shift_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_1 stop_ _Sample_conditions_label $cond_v-Myc_1 _Chem_shift_reference_set_label $chemical_shift_reference _Mol_system_component_name v-myc _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 314 1 SER CA C 61.317 0.1 . 2 315 2 ASN N N 124.416 0.1 . 3 315 2 ASN H H 8.296 0.1 . 4 315 2 ASN CA C 55.070 0.1 . 5 319 6 CYS CA C 58.073 0.1 . 6 320 7 SER N N 117.207 0.1 . 7 320 7 SER H H 7.965 0.1 . 8 320 7 SER CA C 55.533 0.1 . 9 321 8 SER N N 118.903 0.1 . 10 321 8 SER H H 8.203 0.1 . 11 321 8 SER CA C 56.232 0.1 . 12 322 9 PRO CA C 63.113 0.1 . 13 323 10 ARG N N 121.235 0.1 . 14 323 10 ARG H H 8.311 0.1 . 15 323 10 ARG CA C 55.839 0.1 . 16 324 11 THR N N 115.722 0.1 . 17 324 11 THR H H 8.084 0.1 . 18 324 11 THR CA C 61.447 0.1 . 19 325 12 LEU N N 124.416 0.1 . 20 325 12 LEU H H 8.255 0.1 . 21 325 12 LEU CA C 55.178 0.1 . 22 326 13 ASP N N 121.235 0.1 . 23 326 13 ASP H H 8.259 0.1 . 24 326 13 ASP CA C 54.404 0.1 . 25 327 14 SER N N 115.935 0.1 . 26 327 14 SER H H 8.133 0.1 . 27 327 14 SER CA C 58.677 0.1 . 28 328 15 GLU N N 122.719 0.1 . 29 328 15 GLU H H 8.381 0.1 . 30 328 15 GLU CA C 57.029 0.1 . 31 329 16 GLU N N 121.023 0.1 . 32 329 16 GLU H H 8.387 0.1 . 33 329 16 GLU CA C 57.034 0.1 . 34 330 17 ASN N N 118.903 0.1 . 35 330 17 ASN H H 8.236 0.1 . 36 330 17 ASN CA C 53.985 0.1 . 37 331 18 ASP N N 120.811 0.1 . 38 331 18 ASP H H 8.227 0.1 . 39 331 18 ASP CA C 55.001 0.1 . 40 332 19 LYS N N 121.447 0.1 . 41 332 19 LYS H H 8.134 0.1 . 42 332 19 LYS CA C 57.100 0.1 . 43 333 20 ARG N N 119.751 0.1 . 44 333 20 ARG H H 8.076 0.1 . 45 333 20 ARG CA C 56.788 0.1 . 46 334 21 ARG N N 120.599 0.1 . 47 334 21 ARG H H 8.046 0.1 . 48 334 21 ARG CA C 56.604 0.1 . 49 335 22 THR N N 114.238 0.1 . 50 335 22 THR H H 7.991 0.1 . 51 335 22 THR CA C 62.328 0.1 . 52 337 24 ASN CA C 53.743 0.1 . 53 338 25 VAL N N 121.235 0.1 . 54 338 25 VAL H H 8.093 0.1 . 55 338 25 VAL CA C 64.006 0.1 . 56 339 26 LEU N N 123.143 0.1 . 57 339 26 LEU H H 8.065 0.1 . 58 339 26 LEU CA C 56.316 0.1 . 59 340 27 GLU N N 120.811 0.1 . 60 340 27 GLU H H 8.152 0.1 . 61 340 27 GLU CA C 57.807 0.1 . 62 341 28 ARG N N 120.387 0.1 . 63 341 28 ARG H H 8.038 0.1 . 64 341 28 ARG CA C 57.871 0.1 . 65 342 29 GLN N N 119.963 0.1 . 66 342 29 GLN H H 8.146 0.1 . 67 342 29 GLN CA C 57.334 0.1 . 68 343 30 ARG N N 120.811 0.1 . 69 343 30 ARG H H 8.235 0.1 . 70 343 30 ARG CA C 57.570 0.1 . 71 347 34 LEU CA C 56.557 0.1 . 72 348 35 LYS N N 121.023 0.1 . 73 348 35 LYS H H 7.882 0.1 . 74 348 35 LYS CA C 60.172 0.1 . 75 349 36 LEU N N 116.571 0.1 . 76 349 36 LEU H H 7.959 0.1 . 77 349 36 LEU CA C 57.479 0.1 . 78 350 37 ARG N N 119.751 0.1 . 79 350 37 ARG H H 7.715 0.1 . 80 350 37 ARG CA C 58.354 0.1 . 81 351 38 PHE N N 121.235 0.1 . 82 351 38 PHE H H 8.536 0.1 . 83 351 38 PHE CA C 63.255 0.1 . 84 352 39 PHE N N 118.691 0.1 . 85 352 39 PHE H H 8.092 0.1 . 86 352 39 PHE CA C 58.048 0.1 . 87 353 40 ALA N N 121.023 0.1 . 88 353 40 ALA H H 7.854 0.1 . 89 353 40 ALA CA C 54.580 0.1 . 90 354 41 LEU N N 118.267 0.1 . 91 354 41 LEU H H 7.388 0.1 . 92 354 41 LEU CA C 57.441 0.1 . 93 355 42 ARG N N 118.267 0.1 . 94 355 42 ARG H H 8.309 0.1 . 95 355 42 ARG CA C 59.016 0.1 . 96 356 43 ASP N N 113.390 0.1 . 97 356 43 ASP H H 7.783 0.1 . 98 356 43 ASP CA C 55.800 0.1 . 99 357 44 GLN N N 117.207 0.1 . 100 357 44 GLN H H 7.885 0.1 . 101 357 44 GLN CA C 54.474 0.1 . 102 358 45 ILE N N 121.023 0.1 . 103 358 45 ILE H H 7.610 0.1 . 104 358 45 ILE CA C 57.456 0.1 . 105 359 46 PRO CA C 65.775 0.1 . 106 360 47 GLU N N 113.602 0.1 . 107 360 47 GLU H H 8.638 0.1 . 108 360 47 GLU CA C 59.296 0.1 . 109 361 48 VAL N N 134.592 0.1 . 110 361 48 VAL H H 7.442 0.1 . 111 361 48 VAL CA C 60.196 0.1 . 112 362 49 ALA N N 125.264 0.1 . 113 362 49 ALA H H 7.766 0.1 . 114 362 49 ALA CA C 54.135 0.1 . 115 363 50 ASN N N 113.814 0.1 . 116 363 50 ASN H H 8.861 0.1 . 117 363 50 ASN CA C 54.186 0.1 . 118 364 51 ASN N N 117.207 0.1 . 119 364 51 ASN H H 7.791 0.1 . 120 364 51 ASN CA C 51.841 0.1 . 121 365 52 GLU N N 124.628 0.1 . 122 365 52 GLU H H 8.713 0.1 . 123 365 52 GLU CA C 57.716 0.1 . 124 366 53 LYS N N 116.995 0.1 . 125 366 53 LYS H H 7.978 0.1 . 126 366 53 LYS CA C 55.006 0.1 . 127 367 54 ALA N N 124.840 0.1 . 128 367 54 ALA H H 7.089 0.1 . 129 367 54 ALA CA C 50.144 0.1 . 130 369 56 LYS CA C 60.497 0.1 . 131 370 57 VAL N N 114.662 0.1 . 132 370 57 VAL H H 8.517 0.1 . 133 370 57 VAL CA C 65.467 0.1 . 134 371 58 VAL N N 121.023 0.1 . 135 371 58 VAL H H 6.640 0.1 . 136 371 58 VAL CA C 65.526 0.1 . 137 372 59 ILE N N 119.963 0.1 . 138 372 59 ILE H H 7.857 0.1 . 139 372 59 ILE CA C 66.364 0.1 . 140 373 60 LEU N N 116.147 0.1 . 141 373 60 LEU H H 7.925 0.1 . 142 373 60 LEU CA C 57.944 0.1 . 143 374 61 LYS N N 121.659 0.1 . 144 374 61 LYS H H 8.261 0.1 . 145 374 61 LYS CA C 59.825 0.1 . 146 375 62 LYS N N 118.479 0.1 . 147 375 62 LYS H H 8.976 0.1 . 148 375 62 LYS CA C 57.418 0.1 . 149 376 63 ALA N N 123.567 0.1 . 150 376 63 ALA H H 8.809 0.1 . 151 376 63 ALA CA C 55.431 0.1 . 152 377 64 THR N N 116.147 0.1 . 153 377 64 THR H H 7.841 0.1 . 154 377 64 THR CA C 67.019 0.1 . 155 378 65 GLU N N 118.903 0.1 . 156 378 65 GLU H H 7.887 0.1 . 157 378 65 GLU CA C 59.213 0.1 . 158 379 66 TYR N N 121.871 0.1 . 159 379 66 TYR H H 8.618 0.1 . 160 379 66 TYR CA C 59.565 0.1 . 161 380 67 VAL N N 120.599 0.1 . 162 380 67 VAL H H 8.840 0.1 . 163 380 67 VAL CA C 67.681 0.1 . 164 381 68 LEU N N 118.691 0.1 . 165 381 68 LEU H H 7.957 0.1 . 166 381 68 LEU CA C 57.776 0.1 . 167 382 69 SER N N 118.903 0.1 . 168 382 69 SER H H 8.391 0.1 . 169 382 69 SER CA C 61.507 0.1 . 170 383 70 LEU N N 123.780 0.1 . 171 383 70 LEU H H 8.550 0.1 . 172 383 70 LEU CA C 57.792 0.1 . 173 384 71 GLN N N 118.267 0.1 . 174 384 71 GLN H H 7.854 0.1 . 175 384 71 GLN CA C 58.496 0.1 . 176 385 72 SER N N 116.783 0.1 . 177 385 72 SER H H 8.222 0.1 . 178 385 72 SER CA C 61.241 0.1 . 179 386 73 ASP N N 123.143 0.1 . 180 386 73 ASP H H 8.941 0.1 . 181 386 73 ASP CA C 57.084 0.1 . 182 387 74 GLU N N 121.023 0.1 . 183 387 74 GLU H H 8.038 0.1 . 184 387 74 GLU CA C 60.267 0.1 . 185 388 75 HIS N N 115.298 0.1 . 186 388 75 HIS H H 7.660 0.1 . 187 388 75 HIS CA C 59.036 0.1 . 188 389 76 LYS N N 120.599 0.1 . 189 389 76 LYS H H 7.845 0.1 . 190 389 76 LYS CA C 59.336 0.1 . 191 390 77 LEU N N 122.719 0.1 . 192 390 77 LEU H H 8.536 0.1 . 193 390 77 LEU CA C 57.451 0.1 . 194 391 78 ILE N N 119.963 0.1 . 195 391 78 ILE H H 8.535 0.1 . 196 391 78 ILE CA C 65.523 0.1 . 197 392 79 ALA N N 122.083 0.1 . 198 392 79 ALA H H 7.601 0.1 . 199 392 79 ALA CA C 54.860 0.1 . 200 393 80 GLU N N 121.235 0.1 . 201 393 80 GLU H H 8.010 0.1 . 202 393 80 GLU CA C 59.104 0.1 . 203 394 81 LYS N N 120.599 0.1 . 204 394 81 LYS H H 8.566 0.1 . 205 394 81 LYS CA C 60.166 0.1 . 206 395 82 GLU N N 117.843 0.1 . 207 395 82 GLU H H 8.247 0.1 . 208 395 82 GLU CA C 58.719 0.1 . 209 396 83 GLN N N 120.175 0.1 . 210 396 83 GLN H H 7.879 0.1 . 211 396 83 GLN CA C 58.840 0.1 . 212 397 84 LEU N N 121.447 0.1 . 213 397 84 LEU H H 8.373 0.1 . 214 397 84 LEU CA C 57.554 0.1 . 215 398 85 ARG N N 122.507 0.1 . 216 398 85 ARG H H 8.671 0.1 . 217 398 85 ARG CA C 59.723 0.1 . 218 399 86 ARG N N 121.235 0.1 . 219 399 86 ARG H H 8.271 0.1 . 220 399 86 ARG CA C 58.388 0.1 . 221 400 87 ARG N N 121.023 0.1 . 222 400 87 ARG H H 7.999 0.1 . 223 400 87 ARG CA C 58.736 0.1 . 224 401 88 ARG N N 120.811 0.1 . 225 401 88 ARG H H 8.161 0.1 . 226 401 88 ARG CA C 59.336 0.1 . 227 402 89 GLU N N 120.811 0.1 . 228 402 89 GLU H H 8.148 0.1 . 229 402 89 GLU CA C 59.994 0.1 . 230 403 90 GLN N N 116.995 0.1 . 231 403 90 GLN H H 7.845 0.1 . 232 403 90 GLN CA C 58.653 0.1 . 233 404 91 LEU N N 121.659 0.1 . 234 404 91 LEU H H 8.694 0.1 . 235 404 91 LEU CA C 57.964 0.1 . 236 405 92 LYS N N 118.903 0.1 . 237 405 92 LYS H H 8.646 0.1 . 238 405 92 LYS CA C 59.979 0.1 . 239 406 93 HIS N N 118.903 0.1 . 240 406 93 HIS H H 8.111 0.1 . 241 406 93 HIS CA C 58.795 0.1 . 242 407 94 ASN N N 120.175 0.1 . 243 407 94 ASN H H 8.502 0.1 . 244 407 94 ASN CA C 55.725 0.1 . 245 408 95 LEU N N 121.235 0.1 . 246 408 95 LEU H H 8.525 0.1 . 247 408 95 LEU CA C 58.061 0.1 . 248 409 96 GLU N N 118.585 0.1 . 249 409 96 GLU H H 7.937 0.1 . 250 409 96 GLU CA C 58.986 0.1 . 251 410 97 GLN N N 117.843 0.1 . 252 410 97 GLN H H 7.907 0.1 . 253 410 97 GLN CA C 58.085 0.1 . 254 411 98 LEU N N 119.963 0.1 . 255 411 98 LEU H H 7.935 0.1 . 256 411 98 LEU CA C 56.818 0.1 . 257 412 99 ARG N N 118.903 0.1 . 258 412 99 ARG H H 8.174 0.1 . 259 412 99 ARG CA C 58.167 0.1 . 260 413 100 ASN N N 116.995 0.1 . 261 413 100 ASN H H 7.830 0.1 . 262 413 100 ASN CA C 53.424 0.1 . 263 414 101 SER N N 115.510 0.1 . 264 414 101 SER H H 7.837 0.1 . 265 414 101 SER CA C 58.603 0.1 . 266 415 102 ARG N N 122.931 0.1 . 267 415 102 ARG H H 8.118 0.1 . 268 415 102 ARG CA C 54.579 0.1 . 269 416 103 ALA N N 130.776 0.1 . 270 416 103 ALA H H 7.837 0.1 . 271 416 103 ALA CA C 55.620 0.1 . stop_ save_