data_17179 ####################### # Entry information # ####################### save_entry_information _Entry.Sf_category entry_information _Entry.Sf_framecode entry_information _Entry.ID 17179 _Entry.Title ; NMR Studies of the Backbone Flexibility and Structure of Human Growth Hormone: A Comparison of High and Low pH Conformations ; _Entry.Type macromolecule _Entry.Version_type original _Entry.Submission_date 2010-09-10 _Entry.Accession_date 2010-09-10 _Entry.Last_release_date 2010-11-10 _Entry.Original_release_date 2010-11-10 _Entry.Origination author _Entry.NMR_STAR_version 3.1.1.61 _Entry.Original_NMR_STAR_version 3.0.9.13 _Entry.Experimental_method NMR _Entry.Experimental_method_subtype solution _Entry.Details . _Entry.BMRB_internal_directory_name . loop_ _Entry_author.Ordinal _Entry_author.Given_name _Entry_author.Family_name _Entry_author.First_initial _Entry_author.Middle_initials _Entry_author.Family_title _Entry_author.Entry_ID 1 Marina Kasimova . R. . 17179 2 Soren Kristensen . M. . 17179 3 Peter Howe . W.A. . 17179 4 Thorkild Christensen . . . 17179 5 Finn Matthiesen . . . 17179 6 Jorgen Petersen . . . 17179 7 Hans Sorensen . H. . 17179 8 Jens Led . J. . 17179 stop_ loop_ _Data_set.Type _Data_set.Count _Data_set.Entry_ID chemical_rates 2 17179 stop_ loop_ _Datum.Type _Datum.Count _Datum.Entry_ID 'kinetic rates' 182 17179 stop_ loop_ _Release.Release_number _Release.Format_type _Release.Format_version _Release.Date _Release.Submission_date _Release.Type _Release.Author _Release.Detail _Release.Entry_ID 1 . . 2010-11-10 2010-09-10 original author . 17179 stop_ save_ ############### # Citations # ############### save_entry_citation _Citation.Sf_category citations _Citation.Sf_framecode entry_citation _Citation.Entry_ID 17179 _Citation.ID 1 _Citation.Class 'entry citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.DOI . _Citation.PubMed_ID 12054815 _Citation.Full_citation . _Citation.Title 'NMR Studies of the Backbone Flexibility and Structure of Human Growh Hormone: A Comparison of High and Low pH Conformations' _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'J. Mol. Biol.' _Citation.Journal_name_full 'Journal of Molecular Biology' _Citation.Journal_volume 318 _Citation.Journal_issue . _Citation.Journal_ASTM . _Citation.Journal_ISSN . _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 679 _Citation.Page_last 695 _Citation.Year 2002 _Citation.Details . loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 Marina Kasimova . R. . 17179 1 2 Soren Kristensen . M. . 17179 1 3 Peter Howe . W.A. . 17179 1 4 Thorkild Christensen . . . 17179 1 5 Finn Matthiesen . . . 17179 1 6 Jorgen Petersen . . . 17179 1 7 Hans Sorensen . H. . 17179 1 8 Jens Led . J. . 17179 1 stop_ save_ ############################################# # Molecular system (assembly) description # ############################################# save_assembly _Assembly.Sf_category assembly _Assembly.Sf_framecode assembly _Assembly.Entry_ID 17179 _Assembly.ID 1 _Assembly.Name 'rhGH hydrogen exchange' _Assembly.BMRB_code . _Assembly.Number_of_components 1 _Assembly.Organic_ligands . _Assembly.Metal_ions . _Assembly.Non_standard_bonds no _Assembly.Ambiguous_conformational_states . _Assembly.Ambiguous_chem_comp_sites . _Assembly.Molecules_in_chemical_exchange . _Assembly.Paramagnetic no _Assembly.Thiol_state . _Assembly.Molecular_mass . _Assembly.Enzyme_commission_number . _Assembly.Details . _Assembly.DB_query_date . _Assembly.DB_query_revised_last_date . loop_ _Entity_assembly.ID _Entity_assembly.Entity_assembly_name _Entity_assembly.Entity_ID _Entity_assembly.Entity_label _Entity_assembly.Asym_ID _Entity_assembly.PDB_chain_ID _Entity_assembly.Experimental_data_reported _Entity_assembly.Physical_state _Entity_assembly.Conformational_isomer _Entity_assembly.Chemical_exchange_state _Entity_assembly.Magnetic_equivalence_group_code _Entity_assembly.Role _Entity_assembly.Details _Entity_assembly.Entry_ID _Entity_assembly.Assembly_ID 1 rhGH 1 $rhGH A . yes native no no . . . 17179 1 stop_ save_ #################################### # Biological polymers and ligands # #################################### save_rhGH _Entity.Sf_category entity _Entity.Sf_framecode rhGH _Entity.Entry_ID 17179 _Entity.ID 1 _Entity.BMRB_code . _Entity.Name rhGH _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code ; FPTIPLSRLFDNAMLRAHRL HQLAFDTYEEFEEAYIPKEQ KYSFLQNPQASLCFSESIPT PSNREQAQQKSNLQLLRISL LLIQSWLEPVGFLRSVFANS LVYGASDSDVYDLLKDLEEG IQTLMGRLEDGSPRTGQIFK QTYSKFDANSHNDDALLKNY GLLYCFRKDMDKVETFLRIV QCRSVEGSCGF ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states no _Entity.Ambiguous_chem_comp_sites no _Entity.Nstd_monomer no _Entity.Nstd_chirality no _Entity.Nstd_linkage no _Entity.Nonpolymer_comp_ID . _Entity.Nonpolymer_comp_label . _Entity.Number_of_monomers 191 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic no _Entity.Thiol_state 'not reported' _Entity.Src_method . _Entity.Parent_entity_ID 1 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight . _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date 2015-11-25 loop_ _Entity_db_link.Ordinal _Entity_db_link.Author_supplied _Entity_db_link.Database_code _Entity_db_link.Accession_code _Entity_db_link.Entry_mol_code _Entity_db_link.Entry_mol_name _Entity_db_link.Entry_experimental_method _Entity_db_link.Entry_structure_resolution _Entity_db_link.Entry_relation_type _Entity_db_link.Entry_details _Entity_db_link.Chimera_segment_ID _Entity_db_link.Seq_query_to_submitted_percent _Entity_db_link.Seq_subject_length _Entity_db_link.Seq_identity _Entity_db_link.Seq_positive _Entity_db_link.Seq_homology_expectation_val _Entity_db_link.Seq_align_begin _Entity_db_link.Seq_align_end _Entity_db_link.Seq_difference_details _Entity_db_link.Seq_alignment_details _Entity_db_link.Entry_ID _Entity_db_link.Entity_ID 1 yes PDB 1HGU . . . . . . . . . . . . . . . . 17179 1 2 no PDB 1HGU . "Human Growth Hormone" . . . . . 100.00 191 97.91 98.43 1.61e-134 . . . . 17179 1 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . PHE . 17179 1 2 . PRO . 17179 1 3 . THR . 17179 1 4 . ILE . 17179 1 5 . PRO . 17179 1 6 . LEU . 17179 1 7 . SER . 17179 1 8 . ARG . 17179 1 9 . LEU . 17179 1 10 . PHE . 17179 1 11 . ASP . 17179 1 12 . ASN . 17179 1 13 . ALA . 17179 1 14 . MET . 17179 1 15 . LEU . 17179 1 16 . ARG . 17179 1 17 . ALA . 17179 1 18 . HIS . 17179 1 19 . ARG . 17179 1 20 . LEU . 17179 1 21 . HIS . 17179 1 22 . GLN . 17179 1 23 . LEU . 17179 1 24 . ALA . 17179 1 25 . PHE . 17179 1 26 . ASP . 17179 1 27 . THR . 17179 1 28 . TYR . 17179 1 29 . GLU . 17179 1 30 . GLU . 17179 1 31 . PHE . 17179 1 32 . GLU . 17179 1 33 . GLU . 17179 1 34 . ALA . 17179 1 35 . TYR . 17179 1 36 . ILE . 17179 1 37 . PRO . 17179 1 38 . LYS . 17179 1 39 . GLU . 17179 1 40 . GLN . 17179 1 41 . LYS . 17179 1 42 . TYR . 17179 1 43 . SER . 17179 1 44 . PHE . 17179 1 45 . LEU . 17179 1 46 . GLN . 17179 1 47 . ASN . 17179 1 48 . PRO . 17179 1 49 . GLN . 17179 1 50 . ALA . 17179 1 51 . SER . 17179 1 52 . LEU . 17179 1 53 . CYS . 17179 1 54 . PHE . 17179 1 55 . SER . 17179 1 56 . GLU . 17179 1 57 . SER . 17179 1 58 . ILE . 17179 1 59 . PRO . 17179 1 60 . THR . 17179 1 61 . PRO . 17179 1 62 . SER . 17179 1 63 . ASN . 17179 1 64 . ARG . 17179 1 65 . GLU . 17179 1 66 . GLN . 17179 1 67 . ALA . 17179 1 68 . GLN . 17179 1 69 . GLN . 17179 1 70 . LYS . 17179 1 71 . SER . 17179 1 72 . ASN . 17179 1 73 . LEU . 17179 1 74 . GLN . 17179 1 75 . LEU . 17179 1 76 . LEU . 17179 1 77 . ARG . 17179 1 78 . ILE . 17179 1 79 . SER . 17179 1 80 . LEU . 17179 1 81 . LEU . 17179 1 82 . LEU . 17179 1 83 . ILE . 17179 1 84 . GLN . 17179 1 85 . SER . 17179 1 86 . TRP . 17179 1 87 . LEU . 17179 1 88 . GLU . 17179 1 89 . PRO . 17179 1 90 . VAL . 17179 1 91 . GLY . 17179 1 92 . PHE . 17179 1 93 . LEU . 17179 1 94 . ARG . 17179 1 95 . SER . 17179 1 96 . VAL . 17179 1 97 . PHE . 17179 1 98 . ALA . 17179 1 99 . ASN . 17179 1 100 . SER . 17179 1 101 . LEU . 17179 1 102 . VAL . 17179 1 103 . TYR . 17179 1 104 . GLY . 17179 1 105 . ALA . 17179 1 106 . SER . 17179 1 107 . ASP . 17179 1 108 . SER . 17179 1 109 . ASP . 17179 1 110 . VAL . 17179 1 111 . TYR . 17179 1 112 . ASP . 17179 1 113 . LEU . 17179 1 114 . LEU . 17179 1 115 . LYS . 17179 1 116 . ASP . 17179 1 117 . LEU . 17179 1 118 . GLU . 17179 1 119 . GLU . 17179 1 120 . GLY . 17179 1 121 . ILE . 17179 1 122 . GLN . 17179 1 123 . THR . 17179 1 124 . LEU . 17179 1 125 . MET . 17179 1 126 . GLY . 17179 1 127 . ARG . 17179 1 128 . LEU . 17179 1 129 . GLU . 17179 1 130 . ASP . 17179 1 131 . GLY . 17179 1 132 . SER . 17179 1 133 . PRO . 17179 1 134 . ARG . 17179 1 135 . THR . 17179 1 136 . GLY . 17179 1 137 . GLN . 17179 1 138 . ILE . 17179 1 139 . PHE . 17179 1 140 . LYS . 17179 1 141 . GLN . 17179 1 142 . THR . 17179 1 143 . TYR . 17179 1 144 . SER . 17179 1 145 . LYS . 17179 1 146 . PHE . 17179 1 147 . ASP . 17179 1 148 . ALA . 17179 1 149 . ASN . 17179 1 150 . SER . 17179 1 151 . HIS . 17179 1 152 . ASN . 17179 1 153 . ASP . 17179 1 154 . ASP . 17179 1 155 . ALA . 17179 1 156 . LEU . 17179 1 157 . LEU . 17179 1 158 . LYS . 17179 1 159 . ASN . 17179 1 160 . TYR . 17179 1 161 . GLY . 17179 1 162 . LEU . 17179 1 163 . LEU . 17179 1 164 . TYR . 17179 1 165 . CYS . 17179 1 166 . PHE . 17179 1 167 . ARG . 17179 1 168 . LYS . 17179 1 169 . ASP . 17179 1 170 . MET . 17179 1 171 . ASP . 17179 1 172 . LYS . 17179 1 173 . VAL . 17179 1 174 . GLU . 17179 1 175 . THR . 17179 1 176 . PHE . 17179 1 177 . LEU . 17179 1 178 . ARG . 17179 1 179 . ILE . 17179 1 180 . VAL . 17179 1 181 . GLN . 17179 1 182 . CYS . 17179 1 183 . ARG . 17179 1 184 . SER . 17179 1 185 . VAL . 17179 1 186 . GLU . 17179 1 187 . GLY . 17179 1 188 . SER . 17179 1 189 . CYS . 17179 1 190 . GLY . 17179 1 191 . PHE . 17179 1 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . PHE 1 1 17179 1 . PRO 2 2 17179 1 . THR 3 3 17179 1 . ILE 4 4 17179 1 . PRO 5 5 17179 1 . LEU 6 6 17179 1 . SER 7 7 17179 1 . ARG 8 8 17179 1 . LEU 9 9 17179 1 . PHE 10 10 17179 1 . ASP 11 11 17179 1 . ASN 12 12 17179 1 . ALA 13 13 17179 1 . MET 14 14 17179 1 . LEU 15 15 17179 1 . ARG 16 16 17179 1 . ALA 17 17 17179 1 . HIS 18 18 17179 1 . ARG 19 19 17179 1 . LEU 20 20 17179 1 . HIS 21 21 17179 1 . GLN 22 22 17179 1 . LEU 23 23 17179 1 . ALA 24 24 17179 1 . PHE 25 25 17179 1 . ASP 26 26 17179 1 . THR 27 27 17179 1 . TYR 28 28 17179 1 . GLU 29 29 17179 1 . GLU 30 30 17179 1 . PHE 31 31 17179 1 . GLU 32 32 17179 1 . GLU 33 33 17179 1 . ALA 34 34 17179 1 . TYR 35 35 17179 1 . ILE 36 36 17179 1 . PRO 37 37 17179 1 . LYS 38 38 17179 1 . GLU 39 39 17179 1 . GLN 40 40 17179 1 . LYS 41 41 17179 1 . TYR 42 42 17179 1 . SER 43 43 17179 1 . PHE 44 44 17179 1 . LEU 45 45 17179 1 . GLN 46 46 17179 1 . ASN 47 47 17179 1 . PRO 48 48 17179 1 . GLN 49 49 17179 1 . ALA 50 50 17179 1 . SER 51 51 17179 1 . LEU 52 52 17179 1 . CYS 53 53 17179 1 . PHE 54 54 17179 1 . SER 55 55 17179 1 . GLU 56 56 17179 1 . SER 57 57 17179 1 . ILE 58 58 17179 1 . PRO 59 59 17179 1 . THR 60 60 17179 1 . PRO 61 61 17179 1 . SER 62 62 17179 1 . ASN 63 63 17179 1 . ARG 64 64 17179 1 . GLU 65 65 17179 1 . GLN 66 66 17179 1 . ALA 67 67 17179 1 . GLN 68 68 17179 1 . GLN 69 69 17179 1 . LYS 70 70 17179 1 . SER 71 71 17179 1 . ASN 72 72 17179 1 . LEU 73 73 17179 1 . GLN 74 74 17179 1 . LEU 75 75 17179 1 . LEU 76 76 17179 1 . ARG 77 77 17179 1 . ILE 78 78 17179 1 . SER 79 79 17179 1 . LEU 80 80 17179 1 . LEU 81 81 17179 1 . LEU 82 82 17179 1 . ILE 83 83 17179 1 . GLN 84 84 17179 1 . SER 85 85 17179 1 . TRP 86 86 17179 1 . LEU 87 87 17179 1 . GLU 88 88 17179 1 . PRO 89 89 17179 1 . VAL 90 90 17179 1 . GLY 91 91 17179 1 . PHE 92 92 17179 1 . LEU 93 93 17179 1 . ARG 94 94 17179 1 . SER 95 95 17179 1 . VAL 96 96 17179 1 . PHE 97 97 17179 1 . ALA 98 98 17179 1 . ASN 99 99 17179 1 . SER 100 100 17179 1 . LEU 101 101 17179 1 . VAL 102 102 17179 1 . TYR 103 103 17179 1 . GLY 104 104 17179 1 . ALA 105 105 17179 1 . SER 106 106 17179 1 . ASP 107 107 17179 1 . SER 108 108 17179 1 . ASP 109 109 17179 1 . VAL 110 110 17179 1 . TYR 111 111 17179 1 . ASP 112 112 17179 1 . LEU 113 113 17179 1 . LEU 114 114 17179 1 . LYS 115 115 17179 1 . ASP 116 116 17179 1 . LEU 117 117 17179 1 . GLU 118 118 17179 1 . GLU 119 119 17179 1 . GLY 120 120 17179 1 . ILE 121 121 17179 1 . GLN 122 122 17179 1 . THR 123 123 17179 1 . LEU 124 124 17179 1 . MET 125 125 17179 1 . GLY 126 126 17179 1 . ARG 127 127 17179 1 . LEU 128 128 17179 1 . GLU 129 129 17179 1 . ASP 130 130 17179 1 . GLY 131 131 17179 1 . SER 132 132 17179 1 . PRO 133 133 17179 1 . ARG 134 134 17179 1 . THR 135 135 17179 1 . GLY 136 136 17179 1 . GLN 137 137 17179 1 . ILE 138 138 17179 1 . PHE 139 139 17179 1 . LYS 140 140 17179 1 . GLN 141 141 17179 1 . THR 142 142 17179 1 . TYR 143 143 17179 1 . SER 144 144 17179 1 . LYS 145 145 17179 1 . PHE 146 146 17179 1 . ASP 147 147 17179 1 . ALA 148 148 17179 1 . ASN 149 149 17179 1 . SER 150 150 17179 1 . HIS 151 151 17179 1 . ASN 152 152 17179 1 . ASP 153 153 17179 1 . ASP 154 154 17179 1 . ALA 155 155 17179 1 . LEU 156 156 17179 1 . LEU 157 157 17179 1 . LYS 158 158 17179 1 . ASN 159 159 17179 1 . TYR 160 160 17179 1 . GLY 161 161 17179 1 . LEU 162 162 17179 1 . LEU 163 163 17179 1 . TYR 164 164 17179 1 . CYS 165 165 17179 1 . PHE 166 166 17179 1 . ARG 167 167 17179 1 . LYS 168 168 17179 1 . ASP 169 169 17179 1 . MET 170 170 17179 1 . ASP 171 171 17179 1 . LYS 172 172 17179 1 . VAL 173 173 17179 1 . GLU 174 174 17179 1 . THR 175 175 17179 1 . PHE 176 176 17179 1 . LEU 177 177 17179 1 . ARG 178 178 17179 1 . ILE 179 179 17179 1 . VAL 180 180 17179 1 . GLN 181 181 17179 1 . CYS 182 182 17179 1 . ARG 183 183 17179 1 . SER 184 184 17179 1 . VAL 185 185 17179 1 . GLU 186 186 17179 1 . GLY 187 187 17179 1 . SER 188 188 17179 1 . CYS 189 189 17179 1 . GLY 190 190 17179 1 . PHE 191 191 17179 1 stop_ save_ #################### # Natural source # #################### save_natural_source _Entity_natural_src_list.Sf_category natural_source _Entity_natural_src_list.Sf_framecode natural_source _Entity_natural_src_list.Entry_ID 17179 _Entity_natural_src_list.ID 1 loop_ _Entity_natural_src.ID _Entity_natural_src.Entity_ID _Entity_natural_src.Entity_label _Entity_natural_src.Entity_chimera_segment_ID _Entity_natural_src.NCBI_taxonomy_ID _Entity_natural_src.Type _Entity_natural_src.Common _Entity_natural_src.Organism_name_scientific _Entity_natural_src.Organism_name_common _Entity_natural_src.Organism_acronym _Entity_natural_src.ICTVdb_decimal_code _Entity_natural_src.Superkingdom _Entity_natural_src.Kingdom _Entity_natural_src.Genus _Entity_natural_src.Species _Entity_natural_src.Strain _Entity_natural_src.Variant _Entity_natural_src.Subvariant _Entity_natural_src.Organ _Entity_natural_src.Tissue _Entity_natural_src.Tissue_fraction _Entity_natural_src.Cell_line _Entity_natural_src.Cell_type _Entity_natural_src.ATCC_number _Entity_natural_src.Organelle _Entity_natural_src.Cellular_location _Entity_natural_src.Fragment _Entity_natural_src.Fraction _Entity_natural_src.Secretion _Entity_natural_src.Plasmid _Entity_natural_src.Plasmid_details _Entity_natural_src.Gene_mnemonic _Entity_natural_src.Dev_stage _Entity_natural_src.Details _Entity_natural_src.Citation_ID _Entity_natural_src.Citation_label _Entity_natural_src.Entry_ID _Entity_natural_src.Entity_natural_src_list_ID 1 1 $rhGH . 9606 organism . 'Homo sapiens' Human . . Eukaryota Metazoa Homo sapiens . . . . . . . . . . . . . . . . . . . . . 17179 1 stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Entity_experimental_src_list.Sf_category experimental_source _Entity_experimental_src_list.Sf_framecode experimental_source _Entity_experimental_src_list.Entry_ID 17179 _Entity_experimental_src_list.ID 1 loop_ _Entity_experimental_src.ID _Entity_experimental_src.Entity_ID _Entity_experimental_src.Entity_label _Entity_experimental_src.Entity_chimera_segment_ID _Entity_experimental_src.Production_method _Entity_experimental_src.Host_org_scientific_name _Entity_experimental_src.Host_org_name_common _Entity_experimental_src.Host_org_details _Entity_experimental_src.Host_org_NCBI_taxonomy_ID _Entity_experimental_src.Host_org_genus _Entity_experimental_src.Host_org_species _Entity_experimental_src.Host_org_strain _Entity_experimental_src.Host_org_variant _Entity_experimental_src.Host_org_subvariant _Entity_experimental_src.Host_org_organ _Entity_experimental_src.Host_org_tissue _Entity_experimental_src.Host_org_tissue_fraction _Entity_experimental_src.Host_org_cell_line _Entity_experimental_src.Host_org_cell_type _Entity_experimental_src.Host_org_cellular_location _Entity_experimental_src.Host_org_organelle _Entity_experimental_src.Host_org_gene _Entity_experimental_src.Host_org_culture_collection _Entity_experimental_src.Host_org_ATCC_number _Entity_experimental_src.Vector_type _Entity_experimental_src.PDBview_host_org_vector_name _Entity_experimental_src.PDBview_plasmid_name _Entity_experimental_src.Vector_name _Entity_experimental_src.Vector_details _Entity_experimental_src.Vendor_name _Entity_experimental_src.Host_org_dev_stage _Entity_experimental_src.Details _Entity_experimental_src.Citation_ID _Entity_experimental_src.Citation_label _Entity_experimental_src.Entry_ID _Entity_experimental_src.Entity_experimental_src_list_ID 1 1 $rhGH . 'obtained from a vendor' . . . . . . . . . . . . . . . . . . . . . . . . . . 'Novo Nordisk' . . 17179 1 stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Sample.Sf_category sample _Sample.Sf_framecode sample_1 _Sample.Entry_ID 17179 _Sample.ID 1 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'pH was adjusted using DCl' _Sample.Aggregate_sample_number . _Sample.Solvent_system '99.996% H2O' _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 rhGH 'natural abundance' . . 1 $rhGH . . . 0.7 1 mM . . . . 17179 1 2 H2O 'natural abundance' . . . . . . 99.996 . . % . . . . 17179 1 stop_ save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_1 _Sample_condition_list.Entry_ID 17179 _Sample_condition_list.ID 1 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 7.0 . pH 17179 1 pressure ambient . atm 17179 1 temperature 305 . K 17179 1 stop_ save_ save_sample_conditions_2 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_2 _Sample_condition_list.Entry_ID 17179 _Sample_condition_list.ID 2 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 2.7 . pH 17179 2 pressure ambient . atm 17179 2 temperature 305 . K 17179 2 stop_ save_ ############################ # Computer software used # ############################ save_software _Software.Sf_category software _Software.Sf_framecode software _Software.Entry_ID 17179 _Software.ID 1 _Software.Name software _Software.Version . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID na . . 17179 1 stop_ loop_ _Task.Task _Task.Entry_ID _Task.Software_ID na 17179 1 stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _NMR_spectrometer.Sf_category NMR_spectrometer _NMR_spectrometer.Sf_framecode spectrometer_1 _NMR_spectrometer.Entry_ID 17179 _NMR_spectrometer.ID 1 _NMR_spectrometer.Details . _NMR_spectrometer.Manufacturer Varian _NMR_spectrometer.Model 'Unity Inova' _NMR_spectrometer.Serial_number . _NMR_spectrometer.Field_strength 500 save_ save_NMR_spectrometer_list _NMR_spectrometer_list.Sf_category NMR_spectrometer_list _NMR_spectrometer_list.Sf_framecode NMR_spectrometer_list _NMR_spectrometer_list.Entry_ID 17179 _NMR_spectrometer_list.ID 1 loop_ _NMR_spectrometer_view.ID _NMR_spectrometer_view.Name _NMR_spectrometer_view.Manufacturer _NMR_spectrometer_view.Model _NMR_spectrometer_view.Serial_number _NMR_spectrometer_view.Field_strength _NMR_spectrometer_view.Details _NMR_spectrometer_view.Citation_ID _NMR_spectrometer_view.Citation_label _NMR_spectrometer_view.Entry_ID _NMR_spectrometer_view.NMR_spectrometer_list_ID 1 spectrometer_1 Varian 'Unity Inova' . 500 . . . 17179 1 stop_ save_ ############################# # NMR applied experiments # ############################# save_experiment_list _Experiment_list.Sf_category experiment_list _Experiment_list.Sf_framecode experiment_list _Experiment_list.Entry_ID 17179 _Experiment_list.ID 1 _Experiment_list.Details . loop_ _Experiment.ID _Experiment.Name _Experiment.Raw_data_flag _Experiment.NMR_spec_expt_ID _Experiment.NMR_spec_expt_label _Experiment.MS_expt_ID _Experiment.MS_expt_label _Experiment.SAXS_expt_ID _Experiment.SAXS_expt_label _Experiment.FRET_expt_ID _Experiment.FRET_expt_label _Experiment.EMR_expt_ID _Experiment.EMR_expt_label _Experiment.Sample_ID _Experiment.Sample_label _Experiment.Sample_state _Experiment.Sample_volume _Experiment.Sample_volume_units _Experiment.Sample_condition_list_ID _Experiment.Sample_condition_list_label _Experiment.Sample_spinning_rate _Experiment.Sample_angle _Experiment.NMR_tube_type _Experiment.NMR_spectrometer_ID _Experiment.NMR_spectrometer_label _Experiment.NMR_spectrometer_probe_ID _Experiment.NMR_spectrometer_probe_label _Experiment.NMR_spectral_processing_ID _Experiment.NMR_spectral_processing_label _Experiment.Mass_spectrometer_ID _Experiment.Mass_spectrometer_label _Experiment.Xray_instrument_ID _Experiment.Xray_instrument_label _Experiment.Fluorescence_instrument_ID _Experiment.Fluorescence_instrument_label _Experiment.EMR_instrument_ID _Experiment.EMR_instrument_label _Experiment.Chromatographic_system_ID _Experiment.Chromatographic_system_label _Experiment.Chromatographic_column_ID _Experiment.Chromatographic_column_label _Experiment.Entry_ID _Experiment.Experiment_list_ID 1 'HN exchange' no . . . . . . . . . . 1 $sample_1 isotropic . . 2 $sample_conditions_2 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17179 1 2 'HN exchange' no . . . . . . . . . . 1 $sample_1 isotropic . . 1 $sample_conditions_1 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17179 1 stop_ save_ save_Chemical_rate_list_1 _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list_1 _Chemical_rate_list.Entry_ID 17179 _Chemical_rate_list.ID 1 _Chemical_rate_list.Sample_condition_list_ID 2 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_2 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 1 'HN exchange' 1 $sample_1 isotropic 17179 1 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 8 8 ARG . . . kex 0.77 . . 0.33 h-1 . . . . . 17179 1 2 1 . 1 1 9 9 LEU . . . kex 0.16 . . 0.02 h-1 . . . . . 17179 1 3 1 . 1 1 10 10 PHE . . . kex 0.074 . . 0.008 h-1 . . . . . 17179 1 4 1 . 1 1 11 11 ASP . . . kex 0.42 . . 0.08 h-1 . . . . . 17179 1 5 1 . 1 1 12 12 ASN . . . kex 0.038 . . 0.006 h-1 . . . . . 17179 1 6 1 . 1 1 13 13 ALA . . . kex 0.13 . . 0.02 h-1 . . . . . 17179 1 7 1 . 1 1 14 14 MET . . . kex 0.09 . . 0.01 h-1 . . . . . 17179 1 8 1 . 1 1 15 15 LEU . . . kex 0.072 . . 0.006 h-1 . . . . . 17179 1 9 1 . 1 1 16 16 ARG . . . kex 0.09 . . 0.01 h-1 . . . . . 17179 1 10 1 . 1 1 17 17 ALA . . . kex 0.151 . . 0.025 h-1 . . . . . 17179 1 11 1 . 1 1 19 19 ARG . . . kex 0.23 . . 0.03 h-1 . . . . . 17179 1 12 1 . 1 1 20 20 LEU . . . kex 0.036 . . 0.003 h-1 . . . . . 17179 1 13 1 . 1 1 23 23 LEU . . . kex 0.12 . . 0.02 h-1 . . . . . 17179 1 14 1 . 1 1 24 24 ALA . . . kex 0.27 . . 0.08 h-1 . . . . . 17179 1 15 1 . 1 1 32 32 GLU . . . kex 0.076 . . 0.006 h-1 . . . . . 17179 1 16 1 . 1 1 34 34 ALA . . . kex 0.31 . . 0.06 h-1 . . . . . 17179 1 17 1 . 1 1 47 47 ASN . . . kex 0.100 . . 0.015 h-1 . . . . . 17179 1 18 1 . 1 1 49 49 GLN . . . kex 0.09 . . 0.04 h-1 . . . . . 17179 1 19 1 . 1 1 60 60 THR . . . kex 0.047 . . 0.006 h-1 . . . . . 17179 1 20 1 . 1 1 77 77 ARG . . . kex 0.043 . . 0.005 h-1 . . . . . 17179 1 21 1 . 1 1 78 78 ILE . . . kex 0.038 . . 0.004 h-1 . . . . . 17179 1 22 1 . 1 1 79 79 SER . . . kex 0.038 . . 0.004 h-1 . . . . . 17179 1 23 1 . 1 1 80 80 LEU . . . kex 0.032 . . 0.005 h-1 . . . . . 17179 1 24 1 . 1 1 81 81 LEU . . . kex 0.022 . . 0.005 h-1 . . . . . 17179 1 25 1 . 1 1 82 82 LEU . . . kex 0.015 . . 0.006 h-1 . . . . . 17179 1 26 1 . 1 1 83 83 ILE . . . kex 0.020 . . 0.006 h-1 . . . . . 17179 1 27 1 . 1 1 84 84 GLN . . . kex 0.026 . . 0.004 h-1 . . . . . 17179 1 28 1 . 1 1 85 85 SER . . . kex 0.064 . . 0.007 h-1 . . . . . 17179 1 29 1 . 1 1 92 92 PHE . . . kex 0.070 . . 0.012 h-1 . . . . . 17179 1 30 1 . 1 1 93 93 LEU . . . kex 0.039 . . 0.005 h-1 . . . . . 17179 1 31 1 . 1 1 94 94 ARG . . . kex 0.22 . . 0.09 h-1 . . . . . 17179 1 32 1 . 1 1 96 96 VAL . . . kex 0.44 . . 0.23 h-1 . . . . . 17179 1 33 1 . 1 1 105 105 ALA . . . kex 0.023 . . 0.004 h-1 . . . . . 17179 1 34 1 . 1 1 107 107 ASP . . . kex 0.032 . . 0.009 h-1 . . . . . 17179 1 35 1 . 1 1 111 111 TYR . . . kex 0.20 . . 0.02 h-1 . . . . . 17179 1 36 1 . 1 1 113 113 LEU . . . kex 0.054 . . 0.005 h-1 . . . . . 17179 1 37 1 . 1 1 114 114 LEU . . . kex 0.040 . . 0.010 h-1 . . . . . 17179 1 38 1 . 1 1 116 116 ASP . . . kex 0.079 . . 0.006 h-1 . . . . . 17179 1 39 1 . 1 1 117 117 LEU . . . kex 0.016 . . 0.004 h-1 . . . . . 17179 1 40 1 . 1 1 118 118 GLU . . . kex 0.022 . . 0.004 h-1 . . . . . 17179 1 41 1 . 1 1 119 119 GLU . . . kex 0.037 . . 0.005 h-1 . . . . . 17179 1 42 1 . 1 1 120 120 GLY . . . kex 0.041 . . 0.004 h-1 . . . . . 17179 1 43 1 . 1 1 121 121 ILE . . . kex 0.037 . . 0.005 h-1 . . . . . 17179 1 44 1 . 1 1 122 122 GLN . . . kex 0.033 . . 0.004 h-1 . . . . . 17179 1 45 1 . 1 1 123 123 THR . . . kex 0.074 . . 0.005 h-1 . . . . . 17179 1 46 1 . 1 1 125 125 MET . . . kex 0.048 . . 0.011 h-1 . . . . . 17179 1 47 1 . 1 1 126 126 GLY . . . kex 0.14 . . 0.02 h-1 . . . . . 17179 1 48 1 . 1 1 127 127 ARG . . . kex 0.11 . . 0.02 h-1 . . . . . 17179 1 49 1 . 1 1 137 137 GLN . . . kex 0.08 . . 0.02 h-1 . . . . . 17179 1 50 1 . 1 1 138 138 ILE . . . kex 0.082 . . 0.007 h-1 . . . . . 17179 1 51 1 . 1 1 144 144 SER . . . kex 0.051 . . 0.007 h-1 . . . . . 17179 1 52 1 . 1 1 154 154 ASP . . . kex 0.12 . . 0.04 h-1 . . . . . 17179 1 53 1 . 1 1 158 158 LYS . . . kex 0.17 . . 0.08 h-1 . . . . . 17179 1 54 1 . 1 1 162 162 LEU . . . kex 0.14 . . 0.06 h-1 . . . . . 17179 1 55 1 . 1 1 171 171 ASP . . . kex 0.62 . . 0.25 h-1 . . . . . 17179 1 56 1 . 1 1 172 172 LYS . . . kex 0.065 . . 0.011 h-1 . . . . . 17179 1 57 1 . 1 1 173 173 VAL . . . kex 0.034 . . 0.005 h-1 . . . . . 17179 1 58 1 . 1 1 174 174 GLU . . . kex 0.030 . . 0.004 h-1 . . . . . 17179 1 59 1 . 1 1 175 175 THR . . . kex 0.039 . . 0.005 h-1 . . . . . 17179 1 60 1 . 1 1 176 176 PHE . . . kex 0.032 . . 0.008 h-1 . . . . . 17179 1 61 1 . 1 1 177 177 LEU . . . kex 0.051 . . 0.004 h-1 . . . . . 17179 1 62 1 . 1 1 178 178 ARG . . . kex 0.038 . . 0.004 h-1 . . . . . 17179 1 63 1 . 1 1 179 179 ILE . . . kex 0.056 . . 0.005 h-1 . . . . . 17179 1 64 1 . 1 1 180 180 VAL . . . kex 0.021 . . 0.007 h-1 . . . . . 17179 1 65 1 . 1 1 181 181 GLN . . . kex 0.066 . . 0.009 h-1 . . . . . 17179 1 66 1 . 1 1 182 182 CYS . . . kex 0.16 . . 0.03 h-1 . . . . . 17179 1 67 1 . 1 1 183 183 ARG . . . kex 0.32 . . 0.08 h-1 . . . . . 17179 1 68 1 . 1 1 184 184 SER . . . kex 0.30 . . 0.04 h-1 . . . . . 17179 1 69 1 . 1 1 185 185 VAL . . . kex 0.42 . . 0.07 h-1 . . . . . 17179 1 70 1 . 1 1 8 8 ARG . . . P 23.7 . . 10.2 . . . . . . 17179 1 71 1 . 1 1 9 9 LEU . . . P 31.6 . . 3.9 . . . . . . 17179 1 72 1 . 1 1 10 10 PHE . . . P 80.8 . . 8.7 . . . . . . 17179 1 73 1 . 1 1 11 11 ASP . . . P 94.5 . . 18.0 . . . . . . 17179 1 74 1 . 1 1 12 12 ASN . . . P 2325 . . 367 . . . . . . 17179 1 75 1 . 1 1 13 13 ALA . . . P 201.0 . . 30.9 . . . . . . 17179 1 76 1 . 1 1 14 14 MET . . . P 115.2 . . 12.8 . . . . . . 17179 1 77 1 . 1 1 15 15 LEU . . . P 63.45 . . 5.29 . . . . . . 17179 1 78 1 . 1 1 16 16 ARG . . . P 90.3 . . 10.0 . . . . . . 17179 1 79 1 . 1 1 17 17 ALA . . . P 126.0 . . 20.9 . . . . . . 17179 1 80 1 . 1 1 19 19 ARG . . . P 250.2 . . 32.6 . . . . . . 17179 1 81 1 . 1 1 20 20 LEU . . . P 140.3 . . 11.7 . . . . . . 17179 1 82 1 . 1 1 23 23 LEU . . . P 43.00 . . 7.17 . . . . . . 17179 1 83 1 . 1 1 24 24 ALA . . . P 59.0 . . 17.5 . . . . . . 17179 1 84 1 . 1 1 32 32 GLU . . . P 201.1 . . 15.9 . . . . . . 17179 1 85 1 . 1 1 34 34 ALA . . . P 82.1 . . 15.9 . . . . . . 17179 1 86 1 . 1 1 47 47 ASN . . . P 361.4 . . 54.2 . . . . . . 17179 1 87 1 . 1 1 49 49 GLN . . . P 89.1 . . 39.6 . . . . . . 17179 1 88 1 . 1 1 60 60 THR . . . P 107.2 . . 13.7 . . . . . . 17179 1 89 1 . 1 1 77 77 ARG . . . P 189.1 . . 22.0 . . . . . . 17179 1 90 1 . 1 1 78 78 ILE . . . P 80.69 . . 8.49 . . . . . . 17179 1 91 1 . 1 1 79 79 SER . . . P 290.2 . . 30.6 . . . . . . 17179 1 92 1 . 1 1 80 80 LEU . . . P 167.5 . . 26.2 . . . . . . 17179 1 93 1 . 1 1 81 81 LEU . . . P 193.7 . . 44.0 . . . . . . 17179 1 94 1 . 1 1 82 82 LEU . . . P 284 . . 114 . . . . . . 17179 1 95 1 . 1 1 83 83 ILE . . . P 111.5 . . 33.4 . . . . . . 17179 1 96 1 . 1 1 84 84 GLN . . . P 232.8 . . 35.8 . . . . . . 17179 1 97 1 . 1 1 85 85 SER . . . P 450.0 . . 49.2 . . . . . . 17179 1 98 1 . 1 1 92 92 PHE . . . P 126.7 . . 21.7 . . . . . . 17179 1 99 1 . 1 1 93 93 LEU . . . P 93.95 . . 12.0 . . . . . . 17179 1 100 1 . 1 1 94 94 ARG . . . P 36.96 . . 15.1 . . . . . . 17179 1 101 1 . 1 1 96 96 VAL . . . P 8.92 . . 4.66 . . . . . . 17179 1 102 1 . 1 1 105 105 ALA . . . P 1580 . . 275 . . . . . . 17179 1 103 1 . 1 1 107 107 ASP . . . P 2140 . . 602 . . . . . . 17179 1 104 1 . 1 1 111 111 TYR . . . P 28.80 . . 2.88 . . . . . . 17179 1 105 1 . 1 1 113 113 LEU . . . P 193.8 . . 17.9 . . . . . . 17179 1 106 1 . 1 1 114 114 LEU . . . P 107.9 . . 27.3 . . . . . . 17179 1 107 1 . 1 1 116 116 ASP . . . P 578.9 . . 44.0 . . . . . . 17179 1 108 1 . 1 1 117 117 LEU . . . P 654 . . 164 . . . . . . 17179 1 109 1 . 1 1 118 118 GLU . . . P 470.4 . . 85.5 . . . . . . 17179 1 110 1 . 1 1 119 119 GLU . . . P 856 . . 116 . . . . . . 17179 1 111 1 . 1 1 120 120 GLY . . . P 896.3 . . 87.4 . . . . . . 17179 1 112 1 . 1 1 121 121 ILE . . . P 138.3 . . 18.7 . . . . . . 17179 1 113 1 . 1 1 122 122 GLN . . . P 183.4 . . 22.2 . . . . . . 17179 1 114 1 . 1 1 123 123 THR . . . P 144.8 . . 9.8 . . . . . . 17179 1 115 1 . 1 1 125 125 MET . . . P 142.6 . . 32.7 . . . . . . 17179 1 116 1 . 1 1 126 126 GLY . . . P 154.2 . . 22.0 . . . . . . 17179 1 117 1 . 1 1 127 127 ARG . . . P 172.9 . . 31.4 . . . . . . 17179 1 118 1 . 1 1 137 137 GLN . . . P 257.6 . . 64.4 . . . . . . 17179 1 119 1 . 1 1 138 138 ILE . . . P 37.60 . . 3.21 . . . . . . 17179 1 120 1 . 1 1 144 144 SER . . . P 405.0 . . 55.6 . . . . . . 17179 1 121 1 . 1 1 154 154 ASP . . . P 1138 . . 379 . . . . . . 17179 1 122 1 . 1 1 158 158 LYS . . . P 41.80 . . 19.7 . . . . . . 17179 1 123 1 . 1 1 162 162 LEU . . . P 69.42 . . 29.8 . . . . . . 17179 1 124 1 . 1 1 171 171 ASP . . . P 72.16 . . 29.1 . . . . . . 17179 1 125 1 . 1 1 172 172 LYS . . . P 437.4 . . 74.0 . . . . . . 17179 1 126 1 . 1 1 173 173 VAL . . . P 96.7 . . 14.2 . . . . . . 17179 1 127 1 . 1 1 174 174 GLU . . . P 356.6 . . 47.6 . . . . . . 17179 1 128 1 . 1 1 175 175 THR . . . P 406.2 . . 52.1 . . . . . . 17179 1 129 1 . 1 1 176 176 PHE . . . P 247.7 . . 61.9 . . . . . . 17179 1 130 1 . 1 1 177 177 LEU . . . P 71.85 . . 5.63 . . . . . . 17179 1 131 1 . 1 1 178 178 ARG . . . P 214.0 . . 22.5 . . . . . . 17179 1 132 1 . 1 1 179 179 ILE . . . P 54.76 . . 4.89 . . . . . . 17179 1 133 1 . 1 1 180 180 VAL . . . P 73.77 . . 24.6 . . . . . . 17179 1 134 1 . 1 1 181 181 GLN . . . P 127.7 . . 17.4 . . . . . . 17179 1 135 1 . 1 1 182 182 CYS . . . P 253.0 . . 47.4 . . . . . . 17179 1 136 1 . 1 1 183 183 ARG . . . P 78.37 . . 19.6 . . . . . . 17179 1 137 1 . 1 1 184 184 SER . . . P 98.93 . . 13.2 . . . . . . 17179 1 138 1 . 1 1 185 185 VAL . . . P 9.34 . . 1.56 . . . . . . 17179 1 stop_ save_ save_Chemical_rate_list_2 _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list_2 _Chemical_rate_list.Entry_ID 17179 _Chemical_rate_list.ID 2 _Chemical_rate_list.Sample_condition_list_ID 1 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_1 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 2 'HN exchange' 1 $sample_1 isotropic 17179 2 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 17 17 ALA . . . kex 0.15 . . 0.04 h-1 . . . . . 17179 2 2 1 . 1 1 23 23 LEU . . . kex 0.124 . . 0.016 h-1 . . . . . 17179 2 3 1 . 1 1 24 24 ALA . . . kex 0.42 . . 0.15 h-1 . . . . . 17179 2 4 1 . 1 1 28 28 TYR . . . kex 0.026 . . 0.008 h-1 . . . . . 17179 2 5 1 . 1 1 45 45 LEU . . . kex 0.014 . . 0.009 h-1 . . . . . 17179 2 6 1 . 1 1 52 52 LEU . . . kex 0.320 . . 0.273 h-1 . . . . . 17179 2 7 1 . 1 1 60 60 THR . . . kex 0.023 . . 0.004 h-1 . . . . . 17179 2 8 1 . 1 1 83 83 ILE . . . kex 0.025 . . 0.004 h-1 . . . . . 17179 2 9 1 . 1 1 86 86 TRP . . . kex 0.014 . . 0.003 h-1 . . . . . 17179 2 10 1 . 1 1 93 93 LEU . . . kex 0.046 . . 0.012 h-1 . . . . . 17179 2 11 1 . 1 1 98 98 ALA . . . kex 0.065 . . 0.006 h-1 . . . . . 17179 2 12 1 . 1 1 117 117 LEU . . . kex 0.025 . . 0.002 h-1 . . . . . 17179 2 13 1 . 1 1 119 119 GLU . . . kex 0.23 . . 0.05 h-1 . . . . . 17179 2 14 1 . 1 1 124 124 LEU . . . kex 0.35 . . 0.30 h-1 . . . . . 17179 2 15 1 . 1 1 125 125 MET . . . kex 0.057 . . 0.005 h-1 . . . . . 17179 2 16 1 . 1 1 132 132 SER . . . kex 0.28 . . 0.05 h-1 . . . . . 17179 2 17 1 . 1 1 171 171 ASP . . . kex 0.064 . . 0.008 h-1 . . . . . 17179 2 18 1 . 1 1 172 172 LYS . . . kex 0.043 . . 0.006 h-1 . . . . . 17179 2 19 1 . 1 1 174 174 GLU . . . kex 0.004 . . 0.003 h-1 . . . . . 17179 2 20 1 . 1 1 175 175 THR . . . kex 0.11 . . 0.02 h-1 . . . . . 17179 2 21 1 . 1 1 179 179 ILE . . . kex 0.049 . . 0.005 h-1 . . . . . 17179 2 22 1 . 1 1 181 181 GLN . . . kex 0.092 . . 0.016 h-1 . . . . . 17179 2 23 1 . 1 1 17 17 ALA . . . P 209236 . . 55796 . . . . . . 17179 2 24 1 . 1 1 23 23 LEU . . . P 63578 . . 8201 . . . . . . 17179 2 25 1 . 1 1 24 24 ALA . . . P 27118 . . 9459 . . . . . . 17179 2 26 1 . 1 1 28 28 TYR . . . P 679091 . . 190783 . . . . . . 17179 2 27 1 . 1 1 45 45 LEU . . . P 407943 . . 26300 . . . . . . 17179 2 28 1 . 1 1 52 52 LEU . . . P 31015 . . 26463 . . . . . . 17179 2 29 1 . 1 1 60 60 THR . . . P 402717 . . 70160 . . . . . . 17179 2 30 1 . 1 1 83 83 ILE . . . P 86854 . . 13874 . . . . . . 17179 2 31 1 . 1 1 86 86 TRP . . . P 1048576 . . 225338 . . . . . . 17179 2 32 1 . 1 1 93 93 LEU . . . P 124157 . . 32361 . . . . . . 17179 2 33 1 . 1 1 98 98 ALA . . . P 334052 . . 30855 . . . . . . 17179 2 34 1 . 1 1 117 117 LEU . . . P 131458 . . 10500 . . . . . . 17179 2 35 1 . 1 1 119 119 GLU . . . P 17989 . . 3911 . . . . . . 17179 2 36 1 . 1 1 124 124 LEU . . . P 22525 . . 19309 . . . . . . 17179 2 37 1 . 1 1 125 125 MET . . . P 199919 . . 17537 . . . . . . 17179 2 38 1 . 1 1 132 132 SER . . . P 234191 . . 41814 . . . . . . 17179 2 39 1 . 1 1 171 171 ASP . . . P 190787 . . 23833 . . . . . . 17179 2 40 1 . 1 1 172 172 LYS . . . P 265008 . . 36944 . . . . . . 17179 2 41 1 . 1 1 174 174 GLU . . . P 1058444 . . 79040 . . . . . . 17179 2 42 1 . 1 1 175 175 THR . . . P 10394 . . 11842 . . . . . . 17179 2 43 1 . 1 1 179 179 ILE . . . P 119270 . . 12160 . . . . . . 17179 2 44 1 . 1 1 181 181 GLN . . . P 170978 . . 29748 . . . . . . 17179 2 stop_ save_