data_17461 ####################### # Entry information # ####################### save_entry_information _Entry.Sf_category entry_information _Entry.Sf_framecode entry_information _Entry.ID 17461 _Entry.Title ; Multiple Cycles of Global Unfolding of GroEL-bound Cyclophilin A Evidenced by NMR ; _Entry.Type macromolecule _Entry.Version_type original _Entry.Submission_date 2011-02-11 _Entry.Accession_date 2011-02-11 _Entry.Last_release_date 2012-06-06 _Entry.Original_release_date 2012-06-06 _Entry.Origination author _Entry.NMR_STAR_version 3.1.1.61 _Entry.Original_NMR_STAR_version 3.1 _Entry.Experimental_method NMR _Entry.Experimental_method_subtype solution _Entry.Details . _Entry.BMRB_internal_directory_name . loop_ _Entry_author.Ordinal _Entry_author.Given_name _Entry_author.Family_name _Entry_author.First_initial _Entry_author.Middle_initials _Entry_author.Family_title _Entry_author.Entry_ID 1 Sabine Nieba-Axmann . E. . 17461 2 Marcel Ottiger . . . 17461 3 Kurt Wuthrich . . . 17461 4 Andreas Pluckthun . . . 17461 stop_ loop_ _Data_set.Type _Data_set.Count _Data_set.Entry_ID chemical_rates 4 17461 stop_ loop_ _Datum.Type _Datum.Count _Datum.Entry_ID 'kinetic rates' 11 17461 stop_ loop_ _Release.Release_number _Release.Format_type _Release.Format_version _Release.Date _Release.Submission_date _Release.Type _Release.Author _Release.Detail _Release.Entry_ID 1 . . 2012-06-06 2011-02-11 original author . 17461 stop_ save_ ############### # Citations # ############### save_entry_citation _Citation.Sf_category citations _Citation.Sf_framecode entry_citation _Citation.Entry_ID 17461 _Citation.ID 1 _Citation.Class 'entry citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.DOI . _Citation.PubMed_ID . _Citation.Full_citation . _Citation.Title 'Multiple Cycles of Global Unfolding of GroEL-bound Cyclophilin A Evidenced by NMR' _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'J. Mol. Biol.' _Citation.Journal_name_full . _Citation.Journal_volume 271 _Citation.Journal_issue . _Citation.Journal_ASTM . _Citation.Journal_ISSN . _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 803 _Citation.Page_last 818 _Citation.Year 1997 _Citation.Details . loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 Sabine Nieba-Axmann . E. . 17461 1 2 Marcel Ottiger . . . 17461 1 3 Kurt Wuthrich . . . 17461 1 4 Andreas Pluckthun . . . 17461 1 stop_ save_ ############################################# # Molecular system (assembly) description # ############################################# save_assembly _Assembly.Sf_category assembly _Assembly.Sf_framecode assembly _Assembly.Entry_ID 17461 _Assembly.ID 1 _Assembly.Name GroEL _Assembly.BMRB_code . _Assembly.Number_of_components 2 _Assembly.Organic_ligands . _Assembly.Metal_ions . _Assembly.Non_standard_bonds no _Assembly.Ambiguous_conformational_states . _Assembly.Ambiguous_chem_comp_sites . _Assembly.Molecules_in_chemical_exchange . _Assembly.Paramagnetic no _Assembly.Thiol_state . _Assembly.Molecular_mass . _Assembly.Enzyme_commission_number . _Assembly.Details . _Assembly.DB_query_date . _Assembly.DB_query_revised_last_date . loop_ _Entity_assembly.ID _Entity_assembly.Entity_assembly_name _Entity_assembly.Entity_ID _Entity_assembly.Entity_label _Entity_assembly.Asym_ID _Entity_assembly.PDB_chain_ID _Entity_assembly.Experimental_data_reported _Entity_assembly.Physical_state _Entity_assembly.Conformational_isomer _Entity_assembly.Chemical_exchange_state _Entity_assembly.Magnetic_equivalence_group_code _Entity_assembly.Role _Entity_assembly.Details _Entity_assembly.Entry_ID _Entity_assembly.Assembly_ID 1 GroEL 1 $GroEL A . yes native no no . . . 17461 1 2 CypA 2 $CypA B . yes native no no . . . 17461 1 stop_ save_ #################################### # Biological polymers and ligands # #################################### save_GroEL _Entity.Sf_category entity _Entity.Sf_framecode GroEL _Entity.Entry_ID 17461 _Entity.ID 1 _Entity.BMRB_code . _Entity.Name GroEL _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code ; MAAKDVKFGNDARVKMLRGV NVLADAVKVTLGPKGRNVVL DKSFGAPTITKDGVSVAREI ELEDKFENMGAQMVKEVASK ANDAAGDGTTTATVLAQAII TEGLKAVAAGMNPMDLKRGI DKAVTVAVEELKALSVPCSD SKAIAQVGTISANSDETVGK LIAEAMDKVGKEGVITVEDG TGLQDELDVVEGMQFDRGYL SPYFINKPETGAVELESPFI LLADKKISNIREMLPVLEAV AKAGKPLLIIAEDVEGEALA TLVVNTMRGIVKVAAVKAPG FGDRRKAMLQDIATLTGGTV ISEEIGMELEKATLEDLGQA KRVVINKDTTTIIDGVGEEA AIQGRVAQIRQQIEEATSDY DREKLQERVAKLAGGVAVIK VGAATEVEMKEKKARVEDAL HATRAAVEEGVVAGGGVALI RVASKLADLRGQNEDQNVGI KVALRAMEAPLRQIVLNCGE EPSVVANTVKGGDGNYGYNA ATEEYGNMIDMGILDPTKVT RSALQYAASVAGLMITTECM VTDLPKNDAADLGAAGGMGG MGGMGGMM ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states no _Entity.Ambiguous_chem_comp_sites no _Entity.Nstd_monomer no _Entity.Nstd_chirality no _Entity.Nstd_linkage no _Entity.Nonpolymer_comp_ID . _Entity.Nonpolymer_comp_label . _Entity.Number_of_monomers 548 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic no _Entity.Thiol_state 'not reported' _Entity.Src_method . _Entity.Parent_entity_ID 1 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight . _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date 2015-11-25 loop_ _Entity_db_link.Ordinal _Entity_db_link.Author_supplied _Entity_db_link.Database_code _Entity_db_link.Accession_code _Entity_db_link.Entry_mol_code _Entity_db_link.Entry_mol_name _Entity_db_link.Entry_experimental_method _Entity_db_link.Entry_structure_resolution _Entity_db_link.Entry_relation_type _Entity_db_link.Entry_details _Entity_db_link.Chimera_segment_ID _Entity_db_link.Seq_query_to_submitted_percent _Entity_db_link.Seq_subject_length _Entity_db_link.Seq_identity _Entity_db_link.Seq_positive _Entity_db_link.Seq_homology_expectation_val _Entity_db_link.Seq_align_begin _Entity_db_link.Seq_align_end _Entity_db_link.Seq_difference_details _Entity_db_link.Seq_alignment_details _Entity_db_link.Entry_ID _Entity_db_link.Entity_ID 1 no PDB 1AON . "Crystal Structure Of The Asymmetric Chaperonin Complex GroelGROES(ADP)7" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 2 no PDB 1GR5 . "Solution Structure Of Apo Groel By Cryo-electron Microscopy" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 3 no PDB 1GRL . "The Crystal Structure Of The Bacterial Chaperonin Groel At 2.8 Angstroms" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 4 no PDB 1GRU . "Solution Structure Of Groes-Adp7-Groel-Atp7 Complex By Cryo-Em" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 5 no PDB 1J4Z . "Structural And Mechanistic Basis For Allostery In The Bacterial Chaperonin Groel; See Remark 400" . . . . . 99.82 547 99.45 99.45 0.00e+00 . . . . 17461 1 6 no PDB 1KP8 . "Structural Basis For Groel-assisted Protein Folding From The Crystal Structure Of (groel-kmgatp)14 At 2.0 A Resolution" . . . . . 99.82 547 99.63 99.63 0.00e+00 . . . . 17461 1 7 no PDB 1KPO . "Structural And Mechanistic Basis For Allostery In The Bacterial Chaperonin Groel; See Remark 400" . . . . . 99.82 547 99.45 99.45 0.00e+00 . . . . 17461 1 8 no PDB 1MNF . "Domain Motions In Groel Upon Binding Of An Oligopeptide" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 9 no PDB 1OEL . "Conformational Variability In The Refined Structure Of The Chaperonin Groel At 2.8 Angstrom Resolution" . . . . . 99.82 547 99.45 99.63 0.00e+00 . . . . 17461 1 10 no PDB 1PCQ . "Crystal Structure Of Groel-Groes" . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 11 no PDB 1PF9 . Groel-Groes-Adp . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 12 no PDB 1SS8 . Groel . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 13 no PDB 1SVT . "Crystal Structure Of Groel14-groes7-(adp-alfx)7" . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 14 no PDB 1SX3 . Groel14-(atpgammas)14 . . . . . 95.80 525 99.81 99.81 0.00e+00 . . . . 17461 1 15 no PDB 1SX4 . Groel-groes-adp7 . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 16 no PDB 1XCK . "Crystal Structure Of Apo Groel" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 17 no PDB 2C7C . "Fitted Coordinates For Groel-Atp7-Groes Cryo-Em Complex (Emd-1180)" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 18 no PDB 2C7D . "Fitted Coordinates For Groel-adp7-groes Cryo-em Complex (emd-1181)" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 19 no PDB 2C7E . "Revised Atomic Structure Fitting Into A Groel(D398a)-Atp7 Cryo-Em Map (Emd 1047)" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 20 no PDB 2CGT . "Groel-adp-gp31 Complex" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 21 no PDB 2EU1 . "Crystal Structure Of The Chaperonin Groel-E461k" . . . . . 100.00 548 99.64 99.82 0.00e+00 . . . . 17461 1 22 no PDB 2NWC . "A 3.02 Angstrom Crystal Structure Of Wild-Type Apo Groel In A Monoclinic Space Group" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 23 no PDB 2YEY . "Crystal Structure Of The Allosteric-defective Chaperonin Groel E434k Mutant" . . . . . 95.62 524 99.62 99.81 0.00e+00 . . . . 17461 1 24 no PDB 2YNJ . "Groel At Sub-Nanometer Resolution By Constrained Single Particle Tomography" . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 25 no PDB 3C9V . "C7 Symmetrized Structure Of Unliganded Groel At 4.7 Angstrom Resolution From Cryoem" . . . . . 95.99 526 99.81 99.81 0.00e+00 . . . . 17461 1 26 no PDB 3CAU . "D7 Symmetrized Structure Of Unliganded Groel At 4.2 Angstrom Resolution By Cryoem" . . . . . 95.99 526 99.43 99.62 0.00e+00 . . . . 17461 1 27 no PDB 3E76 . "Crystal Structure Of Wild-Type Groel With Bound Thallium Ions" . . . . . 99.82 547 99.82 99.82 0.00e+00 . . . . 17461 1 28 no PDB 3WVL . "Crystal Structure Of The Football-shaped Groel-groes Complex (groel: Groes2:atp14) From Escherichia Coli" . . . . . 100.00 548 99.45 99.45 0.00e+00 . . . . 17461 1 29 no PDB 3ZPZ . "Visualizing Groel-es In The Act Of Encapsulating A Non-native Substrate Protein" . . . . . 95.99 526 99.81 99.81 0.00e+00 . . . . 17461 1 30 no PDB 3ZQ0 . "Visualizing Groel-es In The Act Of Encapsulating A Non-native Substrate Protein" . . . . . 95.62 524 99.81 99.81 0.00e+00 . . . . 17461 1 31 no PDB 3ZQ1 . "Visualizing Groel-es In The Act Of Encapsulating A Non-native Substrate Protein" . . . . . 95.99 526 99.81 99.81 0.00e+00 . . . . 17461 1 32 no PDB 4AAQ . "Atp-Triggered Molecular Mechanics Of The Chaperonin Groel" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 33 no PDB 4AAR . "Atp-Triggered Molecular Mechanics Of The Chaperonin Groel" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 34 no PDB 4AAS . "Atp-triggered Molecular Mechanics Of The Chaperonin Groel" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 35 no PDB 4AAU . "Atp-Triggered Molecular Mechanics Of The Chaperonin Groel" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 36 no PDB 4AB2 . "Atp-Triggered Molecular Mechanics Of The Chaperonin Groel" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 37 no PDB 4AB3 . "Atp-triggered Molecular Mechanics Of The Chaperonin Groel" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 38 no PDB 4HEL . "Crystal Structure Analysis Of Apo-groel Structure" . . . . . 95.80 525 99.81 99.81 0.00e+00 . . . . 17461 1 39 no PDB 4KI8 . "Crystal Structure Of A Groel-adp Complex In The Relaxed Allosteric State" . . . . . 100.00 548 99.45 99.45 0.00e+00 . . . . 17461 1 40 no PDB 4PKN . "Crystal Structure Of The Football-shaped Groel-groes2-(adpbefx)14 Complex Containing Substrate Rubisco" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 41 no PDB 4PKO . "Crystal Structure Of The Football-shaped Groel-groes2-(adpbefx)14 Complex" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 42 no PDB 4WGL . "Crystal Structure Of A Groel D83a/r197a Double Mutant" . . . . . 100.00 548 99.45 99.45 0.00e+00 . . . . 17461 1 43 no PDB 4WSC . "Crystal Structure Of A Groelk105a Mutant" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 44 no DBJ BAA25209 . "similar to GroEL protein [Enterobacter intermedius]" . . . . . 98.54 539 97.22 98.52 0.00e+00 . . . . 17461 1 45 no DBJ BAA25211 . "unnamed protein product [Pluralibacter gergoviae]" . . . . . 98.54 540 97.04 98.15 0.00e+00 . . . . 17461 1 46 no DBJ BAA25229 . "unnamed protein product [Raoultella planticola]" . . . . . 98.54 540 97.41 98.70 0.00e+00 . . . . 17461 1 47 no DBJ BAA94286 . "groEL [Salmonella enterica subsp. enterica serovar Typhimurium]" . . . . . 100.00 548 98.72 99.45 0.00e+00 . . . . 17461 1 48 no DBJ BAB38547 . "chaperonin GroEL [Escherichia coli O157:H7 str. Sakai]" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 49 no EMBL CAA30698 . "unnamed protein product [Escherichia coli]" . . . . . 100.00 548 99.45 99.64 0.00e+00 . . . . 17461 1 50 no EMBL CAC16675 . "GroEL-like protein [Serratia marcescens]" . . . . . 60.04 329 96.96 98.48 0.00e+00 . . . . 17461 1 51 no EMBL CAC18572 . "GroEL-like protein [Serratia marcescens]" . . . . . 60.04 329 97.26 98.78 0.00e+00 . . . . 17461 1 52 no EMBL CAC18574 . "GroEL-like protein [Serratia marcescens]" . . . . . 60.04 329 97.26 98.78 0.00e+00 . . . . 17461 1 53 no EMBL CAC18576 . "GroEL-like protein [Serratia marcescens]" . . . . . 60.04 329 96.96 98.78 0.00e+00 . . . . 17461 1 54 no GB AAA85277 . "GroEL [Salmonella enterica subsp. enterica serovar Typhi str. Ty2]" . . . . . 100.00 548 98.72 99.45 0.00e+00 . . . . 17461 1 55 no GB AAA97042 . "GroEL protein [Escherichia coli str. K-12 substr. MG1655]" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 56 no GB AAC77103 . "Cpn60 chaperonin GroEL, large subunit of GroESL [Escherichia coli str. K-12 substr. MG1655]" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 57 no GB AAG59342 . "GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein [Escherichia coli O157:H7 str. EDL933]" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 58 no GB AAL09389 . "GroEL-like protein [Enterobacter aerogenes]" . . . . . 99.27 545 97.79 98.71 0.00e+00 . . . . 17461 1 59 no PIR AE1045 . "GroEL protein [imported] - Salmonella enterica subsp. enterica serovar Typhi (strain CT18)" . . . . . 100.00 548 98.72 99.45 0.00e+00 . . . . 17461 1 60 no PIR B86110 . "hypothetical protein mopA [imported] - Escherichia coli (strain O157:H7, substrain EDL933)" . . . . . 100.00 548 99.64 99.64 0.00e+00 . . . . 17461 1 61 no PRF 1407243B . "groEL gene" . . . . . 100.00 548 99.45 99.64 0.00e+00 . . . . 17461 1 62 no REF NP_313151 . "molecular chaperone GroEL [Escherichia coli O157:H7 str. Sakai]" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 63 no REF NP_418567 . "Cpn60 chaperonin GroEL, large subunit of GroESL [Escherichia coli str. K-12 substr. MG1655]" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 64 no REF NP_458769 . "GroEL protein [Salmonella enterica subsp. enterica serovar Typhi str. CT18]" . . . . . 100.00 548 98.72 99.45 0.00e+00 . . . . 17461 1 65 no REF NP_463194 . "chaperonin GroEL [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]" . . . . . 100.00 548 98.72 99.45 0.00e+00 . . . . 17461 1 66 no REF NP_710008 . "molecular chaperone GroEL [Shigella flexneri 2a str. 301]" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 67 no SP A1AJ51 . "RecName: Full=60 kDa chaperonin 1; AltName: Full=GroEL protein 1; AltName: Full=Protein Cpn60 1" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 68 no SP A7ZV12 . "RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 69 no SP A8A7N9 . "RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60" . . . . . 100.00 548 99.82 99.82 0.00e+00 . . . . 17461 1 70 no SP A8AMQ6 . "RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60" . . . . . 100.00 548 97.45 98.72 0.00e+00 . . . . 17461 1 71 no SP A9MFR9 . "RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60" . . . . . 100.00 548 98.54 99.27 0.00e+00 . . . . 17461 1 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . MET . 17461 1 2 . ALA . 17461 1 3 . ALA . 17461 1 4 . LYS . 17461 1 5 . ASP . 17461 1 6 . VAL . 17461 1 7 . LYS . 17461 1 8 . PHE . 17461 1 9 . GLY . 17461 1 10 . ASN . 17461 1 11 . ASP . 17461 1 12 . ALA . 17461 1 13 . ARG . 17461 1 14 . VAL . 17461 1 15 . LYS . 17461 1 16 . MET . 17461 1 17 . LEU . 17461 1 18 . ARG . 17461 1 19 . GLY . 17461 1 20 . VAL . 17461 1 21 . ASN . 17461 1 22 . VAL . 17461 1 23 . LEU . 17461 1 24 . ALA . 17461 1 25 . ASP . 17461 1 26 . ALA . 17461 1 27 . VAL . 17461 1 28 . LYS . 17461 1 29 . VAL . 17461 1 30 . THR . 17461 1 31 . LEU . 17461 1 32 . GLY . 17461 1 33 . PRO . 17461 1 34 . LYS . 17461 1 35 . GLY . 17461 1 36 . ARG . 17461 1 37 . ASN . 17461 1 38 . VAL . 17461 1 39 . VAL . 17461 1 40 . LEU . 17461 1 41 . ASP . 17461 1 42 . LYS . 17461 1 43 . SER . 17461 1 44 . PHE . 17461 1 45 . GLY . 17461 1 46 . ALA . 17461 1 47 . PRO . 17461 1 48 . THR . 17461 1 49 . ILE . 17461 1 50 . THR . 17461 1 51 . LYS . 17461 1 52 . ASP . 17461 1 53 . GLY . 17461 1 54 . VAL . 17461 1 55 . SER . 17461 1 56 . VAL . 17461 1 57 . ALA . 17461 1 58 . ARG . 17461 1 59 . GLU . 17461 1 60 . ILE . 17461 1 61 . GLU . 17461 1 62 . LEU . 17461 1 63 . GLU . 17461 1 64 . ASP . 17461 1 65 . LYS . 17461 1 66 . PHE . 17461 1 67 . GLU . 17461 1 68 . ASN . 17461 1 69 . MET . 17461 1 70 . GLY . 17461 1 71 . ALA . 17461 1 72 . GLN . 17461 1 73 . MET . 17461 1 74 . VAL . 17461 1 75 . LYS . 17461 1 76 . GLU . 17461 1 77 . VAL . 17461 1 78 . ALA . 17461 1 79 . SER . 17461 1 80 . LYS . 17461 1 81 . ALA . 17461 1 82 . ASN . 17461 1 83 . ASP . 17461 1 84 . ALA . 17461 1 85 . ALA . 17461 1 86 . GLY . 17461 1 87 . ASP . 17461 1 88 . GLY . 17461 1 89 . THR . 17461 1 90 . THR . 17461 1 91 . THR . 17461 1 92 . ALA . 17461 1 93 . THR . 17461 1 94 . VAL . 17461 1 95 . LEU . 17461 1 96 . ALA . 17461 1 97 . GLN . 17461 1 98 . ALA . 17461 1 99 . ILE . 17461 1 100 . ILE . 17461 1 101 . THR . 17461 1 102 . GLU . 17461 1 103 . GLY . 17461 1 104 . LEU . 17461 1 105 . LYS . 17461 1 106 . ALA . 17461 1 107 . VAL . 17461 1 108 . ALA . 17461 1 109 . ALA . 17461 1 110 . GLY . 17461 1 111 . MET . 17461 1 112 . ASN . 17461 1 113 . PRO . 17461 1 114 . MET . 17461 1 115 . ASP . 17461 1 116 . LEU . 17461 1 117 . LYS . 17461 1 118 . ARG . 17461 1 119 . GLY . 17461 1 120 . ILE . 17461 1 121 . ASP . 17461 1 122 . LYS . 17461 1 123 . ALA . 17461 1 124 . VAL . 17461 1 125 . THR . 17461 1 126 . VAL . 17461 1 127 . ALA . 17461 1 128 . VAL . 17461 1 129 . GLU . 17461 1 130 . GLU . 17461 1 131 . LEU . 17461 1 132 . LYS . 17461 1 133 . ALA . 17461 1 134 . LEU . 17461 1 135 . SER . 17461 1 136 . VAL . 17461 1 137 . PRO . 17461 1 138 . CYS . 17461 1 139 . SER . 17461 1 140 . ASP . 17461 1 141 . SER . 17461 1 142 . LYS . 17461 1 143 . ALA . 17461 1 144 . ILE . 17461 1 145 . ALA . 17461 1 146 . GLN . 17461 1 147 . VAL . 17461 1 148 . GLY . 17461 1 149 . THR . 17461 1 150 . ILE . 17461 1 151 . SER . 17461 1 152 . ALA . 17461 1 153 . ASN . 17461 1 154 . SER . 17461 1 155 . ASP . 17461 1 156 . GLU . 17461 1 157 . THR . 17461 1 158 . VAL . 17461 1 159 . GLY . 17461 1 160 . LYS . 17461 1 161 . LEU . 17461 1 162 . ILE . 17461 1 163 . ALA . 17461 1 164 . GLU . 17461 1 165 . ALA . 17461 1 166 . MET . 17461 1 167 . ASP . 17461 1 168 . LYS . 17461 1 169 . VAL . 17461 1 170 . GLY . 17461 1 171 . LYS . 17461 1 172 . GLU . 17461 1 173 . GLY . 17461 1 174 . VAL . 17461 1 175 . ILE . 17461 1 176 . THR . 17461 1 177 . VAL . 17461 1 178 . GLU . 17461 1 179 . ASP . 17461 1 180 . GLY . 17461 1 181 . THR . 17461 1 182 . GLY . 17461 1 183 . LEU . 17461 1 184 . GLN . 17461 1 185 . ASP . 17461 1 186 . GLU . 17461 1 187 . LEU . 17461 1 188 . ASP . 17461 1 189 . VAL . 17461 1 190 . VAL . 17461 1 191 . GLU . 17461 1 192 . GLY . 17461 1 193 . MET . 17461 1 194 . GLN . 17461 1 195 . PHE . 17461 1 196 . ASP . 17461 1 197 . ARG . 17461 1 198 . GLY . 17461 1 199 . TYR . 17461 1 200 . LEU . 17461 1 201 . SER . 17461 1 202 . PRO . 17461 1 203 . TYR . 17461 1 204 . PHE . 17461 1 205 . ILE . 17461 1 206 . ASN . 17461 1 207 . LYS . 17461 1 208 . PRO . 17461 1 209 . GLU . 17461 1 210 . THR . 17461 1 211 . GLY . 17461 1 212 . ALA . 17461 1 213 . VAL . 17461 1 214 . GLU . 17461 1 215 . LEU . 17461 1 216 . GLU . 17461 1 217 . SER . 17461 1 218 . PRO . 17461 1 219 . PHE . 17461 1 220 . ILE . 17461 1 221 . LEU . 17461 1 222 . LEU . 17461 1 223 . ALA . 17461 1 224 . ASP . 17461 1 225 . LYS . 17461 1 226 . LYS . 17461 1 227 . ILE . 17461 1 228 . SER . 17461 1 229 . ASN . 17461 1 230 . ILE . 17461 1 231 . ARG . 17461 1 232 . GLU . 17461 1 233 . MET . 17461 1 234 . LEU . 17461 1 235 . PRO . 17461 1 236 . VAL . 17461 1 237 . LEU . 17461 1 238 . GLU . 17461 1 239 . ALA . 17461 1 240 . VAL . 17461 1 241 . ALA . 17461 1 242 . LYS . 17461 1 243 . ALA . 17461 1 244 . GLY . 17461 1 245 . LYS . 17461 1 246 . PRO . 17461 1 247 . LEU . 17461 1 248 . LEU . 17461 1 249 . ILE . 17461 1 250 . ILE . 17461 1 251 . ALA . 17461 1 252 . GLU . 17461 1 253 . ASP . 17461 1 254 . VAL . 17461 1 255 . GLU . 17461 1 256 . GLY . 17461 1 257 . GLU . 17461 1 258 . ALA . 17461 1 259 . LEU . 17461 1 260 . ALA . 17461 1 261 . THR . 17461 1 262 . LEU . 17461 1 263 . VAL . 17461 1 264 . VAL . 17461 1 265 . ASN . 17461 1 266 . THR . 17461 1 267 . MET . 17461 1 268 . ARG . 17461 1 269 . GLY . 17461 1 270 . ILE . 17461 1 271 . VAL . 17461 1 272 . LYS . 17461 1 273 . VAL . 17461 1 274 . ALA . 17461 1 275 . ALA . 17461 1 276 . VAL . 17461 1 277 . LYS . 17461 1 278 . ALA . 17461 1 279 . PRO . 17461 1 280 . GLY . 17461 1 281 . PHE . 17461 1 282 . GLY . 17461 1 283 . ASP . 17461 1 284 . ARG . 17461 1 285 . ARG . 17461 1 286 . LYS . 17461 1 287 . ALA . 17461 1 288 . MET . 17461 1 289 . LEU . 17461 1 290 . GLN . 17461 1 291 . ASP . 17461 1 292 . ILE . 17461 1 293 . ALA . 17461 1 294 . THR . 17461 1 295 . LEU . 17461 1 296 . THR . 17461 1 297 . GLY . 17461 1 298 . GLY . 17461 1 299 . THR . 17461 1 300 . VAL . 17461 1 301 . ILE . 17461 1 302 . SER . 17461 1 303 . GLU . 17461 1 304 . GLU . 17461 1 305 . ILE . 17461 1 306 . GLY . 17461 1 307 . MET . 17461 1 308 . GLU . 17461 1 309 . LEU . 17461 1 310 . GLU . 17461 1 311 . LYS . 17461 1 312 . ALA . 17461 1 313 . THR . 17461 1 314 . LEU . 17461 1 315 . GLU . 17461 1 316 . ASP . 17461 1 317 . LEU . 17461 1 318 . GLY . 17461 1 319 . GLN . 17461 1 320 . ALA . 17461 1 321 . LYS . 17461 1 322 . ARG . 17461 1 323 . VAL . 17461 1 324 . VAL . 17461 1 325 . ILE . 17461 1 326 . ASN . 17461 1 327 . LYS . 17461 1 328 . ASP . 17461 1 329 . THR . 17461 1 330 . THR . 17461 1 331 . THR . 17461 1 332 . ILE . 17461 1 333 . ILE . 17461 1 334 . ASP . 17461 1 335 . GLY . 17461 1 336 . VAL . 17461 1 337 . GLY . 17461 1 338 . GLU . 17461 1 339 . GLU . 17461 1 340 . ALA . 17461 1 341 . ALA . 17461 1 342 . ILE . 17461 1 343 . GLN . 17461 1 344 . GLY . 17461 1 345 . ARG . 17461 1 346 . VAL . 17461 1 347 . ALA . 17461 1 348 . GLN . 17461 1 349 . ILE . 17461 1 350 . ARG . 17461 1 351 . GLN . 17461 1 352 . GLN . 17461 1 353 . ILE . 17461 1 354 . GLU . 17461 1 355 . GLU . 17461 1 356 . ALA . 17461 1 357 . THR . 17461 1 358 . SER . 17461 1 359 . ASP . 17461 1 360 . TYR . 17461 1 361 . ASP . 17461 1 362 . ARG . 17461 1 363 . GLU . 17461 1 364 . LYS . 17461 1 365 . LEU . 17461 1 366 . GLN . 17461 1 367 . GLU . 17461 1 368 . ARG . 17461 1 369 . VAL . 17461 1 370 . ALA . 17461 1 371 . LYS . 17461 1 372 . LEU . 17461 1 373 . ALA . 17461 1 374 . GLY . 17461 1 375 . GLY . 17461 1 376 . VAL . 17461 1 377 . ALA . 17461 1 378 . VAL . 17461 1 379 . ILE . 17461 1 380 . LYS . 17461 1 381 . VAL . 17461 1 382 . GLY . 17461 1 383 . ALA . 17461 1 384 . ALA . 17461 1 385 . THR . 17461 1 386 . GLU . 17461 1 387 . VAL . 17461 1 388 . GLU . 17461 1 389 . MET . 17461 1 390 . LYS . 17461 1 391 . GLU . 17461 1 392 . LYS . 17461 1 393 . LYS . 17461 1 394 . ALA . 17461 1 395 . ARG . 17461 1 396 . VAL . 17461 1 397 . GLU . 17461 1 398 . ASP . 17461 1 399 . ALA . 17461 1 400 . LEU . 17461 1 401 . HIS . 17461 1 402 . ALA . 17461 1 403 . THR . 17461 1 404 . ARG . 17461 1 405 . ALA . 17461 1 406 . ALA . 17461 1 407 . VAL . 17461 1 408 . GLU . 17461 1 409 . GLU . 17461 1 410 . GLY . 17461 1 411 . VAL . 17461 1 412 . VAL . 17461 1 413 . ALA . 17461 1 414 . GLY . 17461 1 415 . GLY . 17461 1 416 . GLY . 17461 1 417 . VAL . 17461 1 418 . ALA . 17461 1 419 . LEU . 17461 1 420 . ILE . 17461 1 421 . ARG . 17461 1 422 . VAL . 17461 1 423 . ALA . 17461 1 424 . SER . 17461 1 425 . LYS . 17461 1 426 . LEU . 17461 1 427 . ALA . 17461 1 428 . ASP . 17461 1 429 . LEU . 17461 1 430 . ARG . 17461 1 431 . GLY . 17461 1 432 . GLN . 17461 1 433 . ASN . 17461 1 434 . GLU . 17461 1 435 . ASP . 17461 1 436 . GLN . 17461 1 437 . ASN . 17461 1 438 . VAL . 17461 1 439 . GLY . 17461 1 440 . ILE . 17461 1 441 . LYS . 17461 1 442 . VAL . 17461 1 443 . ALA . 17461 1 444 . LEU . 17461 1 445 . ARG . 17461 1 446 . ALA . 17461 1 447 . MET . 17461 1 448 . GLU . 17461 1 449 . ALA . 17461 1 450 . PRO . 17461 1 451 . LEU . 17461 1 452 . ARG . 17461 1 453 . GLN . 17461 1 454 . ILE . 17461 1 455 . VAL . 17461 1 456 . LEU . 17461 1 457 . ASN . 17461 1 458 . CYS . 17461 1 459 . GLY . 17461 1 460 . GLU . 17461 1 461 . GLU . 17461 1 462 . PRO . 17461 1 463 . SER . 17461 1 464 . VAL . 17461 1 465 . VAL . 17461 1 466 . ALA . 17461 1 467 . ASN . 17461 1 468 . THR . 17461 1 469 . VAL . 17461 1 470 . LYS . 17461 1 471 . GLY . 17461 1 472 . GLY . 17461 1 473 . ASP . 17461 1 474 . GLY . 17461 1 475 . ASN . 17461 1 476 . TYR . 17461 1 477 . GLY . 17461 1 478 . TYR . 17461 1 479 . ASN . 17461 1 480 . ALA . 17461 1 481 . ALA . 17461 1 482 . THR . 17461 1 483 . GLU . 17461 1 484 . GLU . 17461 1 485 . TYR . 17461 1 486 . GLY . 17461 1 487 . ASN . 17461 1 488 . MET . 17461 1 489 . ILE . 17461 1 490 . ASP . 17461 1 491 . MET . 17461 1 492 . GLY . 17461 1 493 . ILE . 17461 1 494 . LEU . 17461 1 495 . ASP . 17461 1 496 . PRO . 17461 1 497 . THR . 17461 1 498 . LYS . 17461 1 499 . VAL . 17461 1 500 . THR . 17461 1 501 . ARG . 17461 1 502 . SER . 17461 1 503 . ALA . 17461 1 504 . LEU . 17461 1 505 . GLN . 17461 1 506 . TYR . 17461 1 507 . ALA . 17461 1 508 . ALA . 17461 1 509 . SER . 17461 1 510 . VAL . 17461 1 511 . ALA . 17461 1 512 . GLY . 17461 1 513 . LEU . 17461 1 514 . MET . 17461 1 515 . ILE . 17461 1 516 . THR . 17461 1 517 . THR . 17461 1 518 . GLU . 17461 1 519 . CYS . 17461 1 520 . MET . 17461 1 521 . VAL . 17461 1 522 . THR . 17461 1 523 . ASP . 17461 1 524 . LEU . 17461 1 525 . PRO . 17461 1 526 . LYS . 17461 1 527 . ASN . 17461 1 528 . ASP . 17461 1 529 . ALA . 17461 1 530 . ALA . 17461 1 531 . ASP . 17461 1 532 . LEU . 17461 1 533 . GLY . 17461 1 534 . ALA . 17461 1 535 . ALA . 17461 1 536 . GLY . 17461 1 537 . GLY . 17461 1 538 . MET . 17461 1 539 . GLY . 17461 1 540 . GLY . 17461 1 541 . MET . 17461 1 542 . GLY . 17461 1 543 . GLY . 17461 1 544 . MET . 17461 1 545 . GLY . 17461 1 546 . GLY . 17461 1 547 . MET . 17461 1 548 . MET . 17461 1 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . MET 1 1 17461 1 . ALA 2 2 17461 1 . ALA 3 3 17461 1 . LYS 4 4 17461 1 . ASP 5 5 17461 1 . VAL 6 6 17461 1 . LYS 7 7 17461 1 . PHE 8 8 17461 1 . GLY 9 9 17461 1 . ASN 10 10 17461 1 . ASP 11 11 17461 1 . ALA 12 12 17461 1 . ARG 13 13 17461 1 . VAL 14 14 17461 1 . LYS 15 15 17461 1 . MET 16 16 17461 1 . LEU 17 17 17461 1 . ARG 18 18 17461 1 . GLY 19 19 17461 1 . VAL 20 20 17461 1 . ASN 21 21 17461 1 . VAL 22 22 17461 1 . LEU 23 23 17461 1 . ALA 24 24 17461 1 . ASP 25 25 17461 1 . ALA 26 26 17461 1 . VAL 27 27 17461 1 . LYS 28 28 17461 1 . VAL 29 29 17461 1 . THR 30 30 17461 1 . LEU 31 31 17461 1 . GLY 32 32 17461 1 . PRO 33 33 17461 1 . LYS 34 34 17461 1 . GLY 35 35 17461 1 . ARG 36 36 17461 1 . ASN 37 37 17461 1 . VAL 38 38 17461 1 . VAL 39 39 17461 1 . LEU 40 40 17461 1 . ASP 41 41 17461 1 . LYS 42 42 17461 1 . SER 43 43 17461 1 . PHE 44 44 17461 1 . GLY 45 45 17461 1 . ALA 46 46 17461 1 . PRO 47 47 17461 1 . THR 48 48 17461 1 . ILE 49 49 17461 1 . THR 50 50 17461 1 . LYS 51 51 17461 1 . ASP 52 52 17461 1 . GLY 53 53 17461 1 . VAL 54 54 17461 1 . SER 55 55 17461 1 . VAL 56 56 17461 1 . ALA 57 57 17461 1 . ARG 58 58 17461 1 . GLU 59 59 17461 1 . ILE 60 60 17461 1 . GLU 61 61 17461 1 . LEU 62 62 17461 1 . GLU 63 63 17461 1 . ASP 64 64 17461 1 . LYS 65 65 17461 1 . PHE 66 66 17461 1 . GLU 67 67 17461 1 . ASN 68 68 17461 1 . MET 69 69 17461 1 . GLY 70 70 17461 1 . ALA 71 71 17461 1 . GLN 72 72 17461 1 . MET 73 73 17461 1 . VAL 74 74 17461 1 . LYS 75 75 17461 1 . GLU 76 76 17461 1 . VAL 77 77 17461 1 . ALA 78 78 17461 1 . SER 79 79 17461 1 . LYS 80 80 17461 1 . ALA 81 81 17461 1 . ASN 82 82 17461 1 . ASP 83 83 17461 1 . ALA 84 84 17461 1 . ALA 85 85 17461 1 . GLY 86 86 17461 1 . ASP 87 87 17461 1 . GLY 88 88 17461 1 . THR 89 89 17461 1 . THR 90 90 17461 1 . THR 91 91 17461 1 . ALA 92 92 17461 1 . THR 93 93 17461 1 . VAL 94 94 17461 1 . LEU 95 95 17461 1 . ALA 96 96 17461 1 . GLN 97 97 17461 1 . ALA 98 98 17461 1 . ILE 99 99 17461 1 . ILE 100 100 17461 1 . THR 101 101 17461 1 . GLU 102 102 17461 1 . GLY 103 103 17461 1 . LEU 104 104 17461 1 . LYS 105 105 17461 1 . ALA 106 106 17461 1 . VAL 107 107 17461 1 . ALA 108 108 17461 1 . ALA 109 109 17461 1 . GLY 110 110 17461 1 . MET 111 111 17461 1 . ASN 112 112 17461 1 . PRO 113 113 17461 1 . MET 114 114 17461 1 . ASP 115 115 17461 1 . LEU 116 116 17461 1 . LYS 117 117 17461 1 . ARG 118 118 17461 1 . GLY 119 119 17461 1 . ILE 120 120 17461 1 . ASP 121 121 17461 1 . LYS 122 122 17461 1 . ALA 123 123 17461 1 . VAL 124 124 17461 1 . THR 125 125 17461 1 . VAL 126 126 17461 1 . ALA 127 127 17461 1 . VAL 128 128 17461 1 . GLU 129 129 17461 1 . GLU 130 130 17461 1 . LEU 131 131 17461 1 . LYS 132 132 17461 1 . ALA 133 133 17461 1 . LEU 134 134 17461 1 . SER 135 135 17461 1 . VAL 136 136 17461 1 . PRO 137 137 17461 1 . CYS 138 138 17461 1 . SER 139 139 17461 1 . ASP 140 140 17461 1 . SER 141 141 17461 1 . LYS 142 142 17461 1 . ALA 143 143 17461 1 . ILE 144 144 17461 1 . ALA 145 145 17461 1 . GLN 146 146 17461 1 . VAL 147 147 17461 1 . GLY 148 148 17461 1 . THR 149 149 17461 1 . ILE 150 150 17461 1 . SER 151 151 17461 1 . ALA 152 152 17461 1 . ASN 153 153 17461 1 . SER 154 154 17461 1 . ASP 155 155 17461 1 . GLU 156 156 17461 1 . THR 157 157 17461 1 . VAL 158 158 17461 1 . GLY 159 159 17461 1 . LYS 160 160 17461 1 . LEU 161 161 17461 1 . ILE 162 162 17461 1 . ALA 163 163 17461 1 . GLU 164 164 17461 1 . ALA 165 165 17461 1 . MET 166 166 17461 1 . ASP 167 167 17461 1 . LYS 168 168 17461 1 . VAL 169 169 17461 1 . GLY 170 170 17461 1 . LYS 171 171 17461 1 . GLU 172 172 17461 1 . GLY 173 173 17461 1 . VAL 174 174 17461 1 . ILE 175 175 17461 1 . THR 176 176 17461 1 . VAL 177 177 17461 1 . GLU 178 178 17461 1 . ASP 179 179 17461 1 . GLY 180 180 17461 1 . THR 181 181 17461 1 . GLY 182 182 17461 1 . LEU 183 183 17461 1 . GLN 184 184 17461 1 . ASP 185 185 17461 1 . GLU 186 186 17461 1 . LEU 187 187 17461 1 . ASP 188 188 17461 1 . VAL 189 189 17461 1 . VAL 190 190 17461 1 . GLU 191 191 17461 1 . GLY 192 192 17461 1 . MET 193 193 17461 1 . GLN 194 194 17461 1 . PHE 195 195 17461 1 . ASP 196 196 17461 1 . ARG 197 197 17461 1 . GLY 198 198 17461 1 . TYR 199 199 17461 1 . LEU 200 200 17461 1 . SER 201 201 17461 1 . PRO 202 202 17461 1 . TYR 203 203 17461 1 . PHE 204 204 17461 1 . ILE 205 205 17461 1 . ASN 206 206 17461 1 . LYS 207 207 17461 1 . PRO 208 208 17461 1 . GLU 209 209 17461 1 . THR 210 210 17461 1 . GLY 211 211 17461 1 . ALA 212 212 17461 1 . VAL 213 213 17461 1 . GLU 214 214 17461 1 . LEU 215 215 17461 1 . GLU 216 216 17461 1 . SER 217 217 17461 1 . PRO 218 218 17461 1 . PHE 219 219 17461 1 . ILE 220 220 17461 1 . LEU 221 221 17461 1 . LEU 222 222 17461 1 . ALA 223 223 17461 1 . ASP 224 224 17461 1 . LYS 225 225 17461 1 . LYS 226 226 17461 1 . ILE 227 227 17461 1 . SER 228 228 17461 1 . ASN 229 229 17461 1 . ILE 230 230 17461 1 . ARG 231 231 17461 1 . GLU 232 232 17461 1 . MET 233 233 17461 1 . LEU 234 234 17461 1 . PRO 235 235 17461 1 . VAL 236 236 17461 1 . LEU 237 237 17461 1 . GLU 238 238 17461 1 . ALA 239 239 17461 1 . VAL 240 240 17461 1 . ALA 241 241 17461 1 . LYS 242 242 17461 1 . ALA 243 243 17461 1 . GLY 244 244 17461 1 . LYS 245 245 17461 1 . PRO 246 246 17461 1 . LEU 247 247 17461 1 . LEU 248 248 17461 1 . ILE 249 249 17461 1 . ILE 250 250 17461 1 . ALA 251 251 17461 1 . GLU 252 252 17461 1 . ASP 253 253 17461 1 . VAL 254 254 17461 1 . GLU 255 255 17461 1 . GLY 256 256 17461 1 . GLU 257 257 17461 1 . ALA 258 258 17461 1 . LEU 259 259 17461 1 . ALA 260 260 17461 1 . THR 261 261 17461 1 . LEU 262 262 17461 1 . VAL 263 263 17461 1 . VAL 264 264 17461 1 . ASN 265 265 17461 1 . THR 266 266 17461 1 . MET 267 267 17461 1 . ARG 268 268 17461 1 . GLY 269 269 17461 1 . ILE 270 270 17461 1 . VAL 271 271 17461 1 . LYS 272 272 17461 1 . VAL 273 273 17461 1 . ALA 274 274 17461 1 . ALA 275 275 17461 1 . VAL 276 276 17461 1 . LYS 277 277 17461 1 . ALA 278 278 17461 1 . PRO 279 279 17461 1 . GLY 280 280 17461 1 . PHE 281 281 17461 1 . GLY 282 282 17461 1 . ASP 283 283 17461 1 . ARG 284 284 17461 1 . ARG 285 285 17461 1 . LYS 286 286 17461 1 . ALA 287 287 17461 1 . MET 288 288 17461 1 . LEU 289 289 17461 1 . GLN 290 290 17461 1 . ASP 291 291 17461 1 . ILE 292 292 17461 1 . ALA 293 293 17461 1 . THR 294 294 17461 1 . LEU 295 295 17461 1 . THR 296 296 17461 1 . GLY 297 297 17461 1 . GLY 298 298 17461 1 . THR 299 299 17461 1 . VAL 300 300 17461 1 . ILE 301 301 17461 1 . SER 302 302 17461 1 . GLU 303 303 17461 1 . GLU 304 304 17461 1 . ILE 305 305 17461 1 . GLY 306 306 17461 1 . MET 307 307 17461 1 . GLU 308 308 17461 1 . LEU 309 309 17461 1 . GLU 310 310 17461 1 . LYS 311 311 17461 1 . ALA 312 312 17461 1 . THR 313 313 17461 1 . LEU 314 314 17461 1 . GLU 315 315 17461 1 . ASP 316 316 17461 1 . LEU 317 317 17461 1 . GLY 318 318 17461 1 . GLN 319 319 17461 1 . ALA 320 320 17461 1 . LYS 321 321 17461 1 . ARG 322 322 17461 1 . VAL 323 323 17461 1 . VAL 324 324 17461 1 . ILE 325 325 17461 1 . ASN 326 326 17461 1 . LYS 327 327 17461 1 . ASP 328 328 17461 1 . THR 329 329 17461 1 . THR 330 330 17461 1 . THR 331 331 17461 1 . ILE 332 332 17461 1 . ILE 333 333 17461 1 . ASP 334 334 17461 1 . GLY 335 335 17461 1 . VAL 336 336 17461 1 . GLY 337 337 17461 1 . GLU 338 338 17461 1 . GLU 339 339 17461 1 . ALA 340 340 17461 1 . ALA 341 341 17461 1 . ILE 342 342 17461 1 . GLN 343 343 17461 1 . GLY 344 344 17461 1 . ARG 345 345 17461 1 . VAL 346 346 17461 1 . ALA 347 347 17461 1 . GLN 348 348 17461 1 . ILE 349 349 17461 1 . ARG 350 350 17461 1 . GLN 351 351 17461 1 . GLN 352 352 17461 1 . ILE 353 353 17461 1 . GLU 354 354 17461 1 . GLU 355 355 17461 1 . ALA 356 356 17461 1 . THR 357 357 17461 1 . SER 358 358 17461 1 . ASP 359 359 17461 1 . TYR 360 360 17461 1 . ASP 361 361 17461 1 . ARG 362 362 17461 1 . GLU 363 363 17461 1 . LYS 364 364 17461 1 . LEU 365 365 17461 1 . GLN 366 366 17461 1 . GLU 367 367 17461 1 . ARG 368 368 17461 1 . VAL 369 369 17461 1 . ALA 370 370 17461 1 . LYS 371 371 17461 1 . LEU 372 372 17461 1 . ALA 373 373 17461 1 . GLY 374 374 17461 1 . GLY 375 375 17461 1 . VAL 376 376 17461 1 . ALA 377 377 17461 1 . VAL 378 378 17461 1 . ILE 379 379 17461 1 . LYS 380 380 17461 1 . VAL 381 381 17461 1 . GLY 382 382 17461 1 . ALA 383 383 17461 1 . ALA 384 384 17461 1 . THR 385 385 17461 1 . GLU 386 386 17461 1 . VAL 387 387 17461 1 . GLU 388 388 17461 1 . MET 389 389 17461 1 . LYS 390 390 17461 1 . GLU 391 391 17461 1 . LYS 392 392 17461 1 . LYS 393 393 17461 1 . ALA 394 394 17461 1 . ARG 395 395 17461 1 . VAL 396 396 17461 1 . GLU 397 397 17461 1 . ASP 398 398 17461 1 . ALA 399 399 17461 1 . LEU 400 400 17461 1 . HIS 401 401 17461 1 . ALA 402 402 17461 1 . THR 403 403 17461 1 . ARG 404 404 17461 1 . ALA 405 405 17461 1 . ALA 406 406 17461 1 . VAL 407 407 17461 1 . GLU 408 408 17461 1 . GLU 409 409 17461 1 . GLY 410 410 17461 1 . VAL 411 411 17461 1 . VAL 412 412 17461 1 . ALA 413 413 17461 1 . GLY 414 414 17461 1 . GLY 415 415 17461 1 . GLY 416 416 17461 1 . VAL 417 417 17461 1 . ALA 418 418 17461 1 . LEU 419 419 17461 1 . ILE 420 420 17461 1 . ARG 421 421 17461 1 . VAL 422 422 17461 1 . ALA 423 423 17461 1 . SER 424 424 17461 1 . LYS 425 425 17461 1 . LEU 426 426 17461 1 . ALA 427 427 17461 1 . ASP 428 428 17461 1 . LEU 429 429 17461 1 . ARG 430 430 17461 1 . GLY 431 431 17461 1 . GLN 432 432 17461 1 . ASN 433 433 17461 1 . GLU 434 434 17461 1 . ASP 435 435 17461 1 . GLN 436 436 17461 1 . ASN 437 437 17461 1 . VAL 438 438 17461 1 . GLY 439 439 17461 1 . ILE 440 440 17461 1 . LYS 441 441 17461 1 . VAL 442 442 17461 1 . ALA 443 443 17461 1 . LEU 444 444 17461 1 . ARG 445 445 17461 1 . ALA 446 446 17461 1 . MET 447 447 17461 1 . GLU 448 448 17461 1 . ALA 449 449 17461 1 . PRO 450 450 17461 1 . LEU 451 451 17461 1 . ARG 452 452 17461 1 . GLN 453 453 17461 1 . ILE 454 454 17461 1 . VAL 455 455 17461 1 . LEU 456 456 17461 1 . ASN 457 457 17461 1 . CYS 458 458 17461 1 . GLY 459 459 17461 1 . GLU 460 460 17461 1 . GLU 461 461 17461 1 . PRO 462 462 17461 1 . SER 463 463 17461 1 . VAL 464 464 17461 1 . VAL 465 465 17461 1 . ALA 466 466 17461 1 . ASN 467 467 17461 1 . THR 468 468 17461 1 . VAL 469 469 17461 1 . LYS 470 470 17461 1 . GLY 471 471 17461 1 . GLY 472 472 17461 1 . ASP 473 473 17461 1 . GLY 474 474 17461 1 . ASN 475 475 17461 1 . TYR 476 476 17461 1 . GLY 477 477 17461 1 . TYR 478 478 17461 1 . ASN 479 479 17461 1 . ALA 480 480 17461 1 . ALA 481 481 17461 1 . THR 482 482 17461 1 . GLU 483 483 17461 1 . GLU 484 484 17461 1 . TYR 485 485 17461 1 . GLY 486 486 17461 1 . ASN 487 487 17461 1 . MET 488 488 17461 1 . ILE 489 489 17461 1 . ASP 490 490 17461 1 . MET 491 491 17461 1 . GLY 492 492 17461 1 . ILE 493 493 17461 1 . LEU 494 494 17461 1 . ASP 495 495 17461 1 . PRO 496 496 17461 1 . THR 497 497 17461 1 . LYS 498 498 17461 1 . VAL 499 499 17461 1 . THR 500 500 17461 1 . ARG 501 501 17461 1 . SER 502 502 17461 1 . ALA 503 503 17461 1 . LEU 504 504 17461 1 . GLN 505 505 17461 1 . TYR 506 506 17461 1 . ALA 507 507 17461 1 . ALA 508 508 17461 1 . SER 509 509 17461 1 . VAL 510 510 17461 1 . ALA 511 511 17461 1 . GLY 512 512 17461 1 . LEU 513 513 17461 1 . MET 514 514 17461 1 . ILE 515 515 17461 1 . THR 516 516 17461 1 . THR 517 517 17461 1 . GLU 518 518 17461 1 . CYS 519 519 17461 1 . MET 520 520 17461 1 . VAL 521 521 17461 1 . THR 522 522 17461 1 . ASP 523 523 17461 1 . LEU 524 524 17461 1 . PRO 525 525 17461 1 . LYS 526 526 17461 1 . ASN 527 527 17461 1 . ASP 528 528 17461 1 . ALA 529 529 17461 1 . ALA 530 530 17461 1 . ASP 531 531 17461 1 . LEU 532 532 17461 1 . GLY 533 533 17461 1 . ALA 534 534 17461 1 . ALA 535 535 17461 1 . GLY 536 536 17461 1 . GLY 537 537 17461 1 . MET 538 538 17461 1 . GLY 539 539 17461 1 . GLY 540 540 17461 1 . MET 541 541 17461 1 . GLY 542 542 17461 1 . GLY 543 543 17461 1 . MET 544 544 17461 1 . GLY 545 545 17461 1 . GLY 546 546 17461 1 . MET 547 547 17461 1 . MET 548 548 17461 1 stop_ save_ save_CypA _Entity.Sf_category entity _Entity.Sf_framecode CypA _Entity.Entry_ID 17461 _Entity.ID 2 _Entity.BMRB_code . _Entity.Name CypA _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code ; MVNPTVFFDIAVDGEPLGRV SFELFADKVPKTAENFRALS TGEKGFGYKGSCFHRIIPGF MCQGGDFTRHNGTGGKSIYG EKFEDENFILKHTGPGILSM ANAGPNTNGSQFFICTAKTE WLDGKHVVFGKVKEGMNIVE AMERFGSRNGKTSKKITIAD CGQLE ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states no _Entity.Ambiguous_chem_comp_sites no _Entity.Nstd_monomer no _Entity.Nstd_chirality no _Entity.Nstd_linkage no _Entity.Nonpolymer_comp_ID . _Entity.Nonpolymer_comp_label . _Entity.Number_of_monomers 165 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic no _Entity.Thiol_state 'not reported' _Entity.Src_method . _Entity.Parent_entity_ID 2 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight . _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date 2015-01-30 loop_ _Entity_db_link.Ordinal _Entity_db_link.Author_supplied _Entity_db_link.Database_code _Entity_db_link.Accession_code _Entity_db_link.Entry_mol_code _Entity_db_link.Entry_mol_name _Entity_db_link.Entry_experimental_method _Entity_db_link.Entry_structure_resolution _Entity_db_link.Entry_relation_type _Entity_db_link.Entry_details _Entity_db_link.Chimera_segment_ID _Entity_db_link.Seq_query_to_submitted_percent _Entity_db_link.Seq_subject_length _Entity_db_link.Seq_identity _Entity_db_link.Seq_positive _Entity_db_link.Seq_homology_expectation_val _Entity_db_link.Seq_align_begin _Entity_db_link.Seq_align_end _Entity_db_link.Seq_difference_details _Entity_db_link.Seq_alignment_details _Entity_db_link.Entry_ID _Entity_db_link.Entity_ID 1 no BMRB 17218 . CypA . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 2 no BMRB 2208 . cyclophilin . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 3 no BMRB 25337 . CypA . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 4 no BMRB 531 . "peptidylprolyl isomerase" . . . . . 98.79 163 98.77 100.00 6.81e-114 . . . . 17461 2 5 no BMRB 532 . "peptidylprolyl isomerase" . . . . . 98.79 163 98.77 100.00 6.81e-114 . . . . 17461 2 6 no PDB 1AK4 . "Human Cyclophilin A Bound To The Amino-Terminal Domain Of Hiv-1 Capsid" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 7 no PDB 1AWQ . "Cypa Complexed With Hagpia (Pseudo-Symmetric Monomer)" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 8 no PDB 1AWR . "Cypa Complexed With Hagpia" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 9 no PDB 1AWS . "Secypa Complexed With Hagpia (Pseudo-Symmetric Monomer)" . . . . . 99.39 164 97.56 97.56 2.78e-111 . . . . 17461 2 10 no PDB 1AWT . "Secypa Complexed With Hagpia" . . . . . 99.39 164 97.56 97.56 2.78e-111 . . . . 17461 2 11 no PDB 1AWU . "Cypa Complexed With Hvgpia (Pseudo-Symmetric Monomer)" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 12 no PDB 1AWV . "Cypa Complexed With Hvgpia" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 13 no PDB 1BCK . "Human Cyclophilin A Complexed With 2-Thr Cyclosporin" . . . . . 99.39 165 100.00 100.00 1.90e-115 . . . . 17461 2 14 no PDB 1CWA . "X-Ray Structure Of A Monomeric Cyclophilin A-Cyclosporin A Crystal Complex At 2.1 Angstroms Resolution" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 15 no PDB 1CWB . "The X-Ray Structure Of (Mebm2t)1-Cyclosporin Complexed With Cyclophilin A Provides An Explanation For Its Anomalously High Immu" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 16 no PDB 1CWC . "Improved Binding Affinity For Cyclophilin A By A Cyclosporin Derivative Singly Modified At Its Effector Domain" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 17 no PDB 1CWF . "Human Cyclophilin A Complexed With 2-Val Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 18 no PDB 1CWH . "Human Cyclophilin A Complexed With 3-D-Ser Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 19 no PDB 1CWI . "Human Cyclophilin A Complexed With 2-Val 3-(N-Methyl)-D-Alanine Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 20 no PDB 1CWJ . "Human Cyclophilin A Complexed With 2-Val 3-S-Methyl-Sarcosine Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 21 no PDB 1CWK . "Human Cyclophilin A Complexed With 1-(6,7-Dihydro)mebmt 2-Val 3-D-(2- S-Methyl)sarcosine Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 22 no PDB 1CWL . "Human Cyclophilin A Complexed With 4 4-Hydroxy-Meleu Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 23 no PDB 1CWM . "Human Cyclophilin A Complexed With 4 Meile Cyclosporin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 24 no PDB 1CWO . "Human Cyclophilin A Complexed With Thr2, Leu5, D-Hiv8, Leu10 Cyclosporin" . . . . . 99.39 165 100.00 100.00 1.90e-115 . . . . 17461 2 25 no PDB 1FGL . "Cyclophilin A Complexed With A Fragment Of Hiv-1 Gag Protein" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 26 no PDB 1M63 . "Crystal Structure Of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition Of Immunophilin-Drug Complexes" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 27 no PDB 1M9C . "X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain (1-146) M-Type Complex." . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 28 no PDB 1M9D . "X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain (1-146) O-Type Chimera Complex." . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 29 no PDB 1M9E . "X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain (1-146) M-Type H87a Complex" . . . . . 99.39 164 100.00 100.00 1.14e-115 . . . . 17461 2 30 no PDB 1M9F . "X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain (1-146) M-Type H87a,A88m Complex." . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 31 no PDB 1M9X . "X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain (1-146) M-Type H87a,A88m,G89a Complex." . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 32 no PDB 1M9Y . "X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain (1-146) M-Type H87a,G89a Complex." . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 33 no PDB 1MF8 . "Crystal Structure Of Human Calcineurin Complexed With Cyclosporin A And Human Cyclophilin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 34 no PDB 1MIK . "The Role Of Water Molecules In The Structure-Based Design Of (5- Hydroxynorvaline)-2-Cyclosporin: Synthesis, Biological Activit" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 35 no PDB 1NMK . "The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-Ray Crystal Structure And Bindin" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 36 no PDB 1OCA . "Human Cyclophilin A, Unligated, Nmr, 20 Structures" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 37 no PDB 1RMH . "Recombinant Cyclophilin A From Human T Cell" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 38 no PDB 1VBS . "Structure Of Cyclophilin Complexed With (D)ala Containing Tetrapeptide" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 39 no PDB 1VBT . "Structure Of Cyclophilin Complexed With Sulfur-Substituted Tetrapeptide Aapf" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 40 no PDB 1W8L . "Enzymatic And Structural Characterization Of Non Peptide Ligand Cyclophilin Complexes" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 41 no PDB 1W8M . "Enzymatic And Structural Characterisation Of Non Peptide Ligand Cyclophilin Complexes" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 42 no PDB 1W8V . "Enzymatic And Structural Characterization Of Non Peptide Ligand Cyclophilin Complexes" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 43 no PDB 1YND . "Structure Of Human Cyclophilin A In Complex With The Novel Immunosuppressant Sanglifehrin A At 1.6a Resolution" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 44 no PDB 1ZKF . "Cyrstal Structure Of Human Cyclophilin-A In Complex With Suc-Agpf-Pna" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 45 no PDB 2ALF . "Crystal Structure Of Human Cypa Mutant K131a" . . . . . 99.39 164 98.78 99.39 3.78e-114 . . . . 17461 2 46 no PDB 2CPL . "Similarities And Differences Between Human Cyclophilin A And Other Beta-Barrel Structures. Structural Refinement At 1.63 Angstr" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 47 no PDB 2CYH . "Cyclophilin A Complexed With Dipeptide Ala-Pro" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 48 no PDB 2RMA . "Crystal Structures Of Cyclophilin A Complexed With Cyclosporin A And N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclospor" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 49 no PDB 2RMB . "Crystal Structures Of Cyclophilin A Complexed With Cyclosporin A And N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclospor" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 50 no PDB 2WLW . "Structure Of The N-Terminal Capsid Domain Of Hiv-2" . . . . . 100.00 165 98.79 99.39 9.87e-115 . . . . 17461 2 51 no PDB 2X25 . "Free Acetyl-Cypa Orthorhombic Form" . . . . . 99.39 169 98.78 99.39 6.80e-114 . . . . 17461 2 52 no PDB 2X2A . "Free Acetyl-Cypa Trigonal Form" . . . . . 100.00 165 98.79 99.39 5.78e-115 . . . . 17461 2 53 no PDB 2X2C . "Acetyl-Cypa:cyclosporine Complex" . . . . . 100.00 165 99.39 99.39 1.31e-115 . . . . 17461 2 54 no PDB 2X2D . "Acetyl-Cypa:hiv-1 N-Term Capsid Domain Complex" . . . . . 100.00 165 99.39 99.39 1.31e-115 . . . . 17461 2 55 no PDB 2X83 . "Evolutionary Basis Of Hiv Restriction By The Antiretroviral Trimcyp" . . . . . 98.79 163 98.77 99.39 3.59e-113 . . . . 17461 2 56 no PDB 2XGY . "Complex Of Rabbit Endogenous Lentivirus (Relik)capsid With Cyclophilin A" . . . . . 100.00 173 100.00 100.00 5.70e-116 . . . . 17461 2 57 no PDB 3CYH . "Cyclophilin A Complexed With Dipeptide Ser-Pro" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 58 no PDB 3CYS . "Determination Of The Nmr Solution Structure Of The Cyclophilin A- Cyclosporin A Complex" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 59 no PDB 3K0M . "Cryogenic Structure Of Cypa" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 60 no PDB 3K0N . "Room Temperature Structure Of Cypa" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 61 no PDB 3K0O . "Room Temperature Structure Of Cypa Mutant Ser99thr" . . . . . 100.00 165 99.39 100.00 7.16e-116 . . . . 17461 2 62 no PDB 3K0P . "Cryogenic Structure Of Cypa Mutant Ser99thr" . . . . . 100.00 165 99.39 100.00 7.16e-116 . . . . 17461 2 63 no PDB 3K0Q . "Cryogenic Structure Of Cypa Mutant Ser99thr (2)" . . . . . 100.00 165 99.39 100.00 7.16e-116 . . . . 17461 2 64 no PDB 3K0R . "Cryogenic Structure Of Cypa Mutant Arg55lys" . . . . . 100.00 165 99.39 100.00 8.72e-116 . . . . 17461 2 65 no PDB 3ODI . "Crystal Structure Of Cyclophilin A In Complex With Voclosporin E- Isa247" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 66 no PDB 3ODL . "Crystal Structure Of Cyclophilin A In Complex With Voclosporin Z- Isa247" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 67 no PDB 3RDD . "Human Cyclophilin A Complexed With An Inhibitor" . . . . . 100.00 184 100.00 100.00 2.73e-116 . . . . 17461 2 68 no PDB 4CYH . "Cyclophilin A Complexed With Dipeptide His-Pro" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 69 no PDB 4DGA . "Trimcyp Cyclophilin Domain From Macaca Mulatta: Hiv-1 Ca(O-Loop) Complex" . . . . . 100.00 165 98.79 99.39 9.87e-115 . . . . 17461 2 70 no PDB 4DGB . "Trimcyp Cyclophilin Domain From Macaca Mulatta: Hiv-2 Ca Cyclophilin- Binding Loop Complex" . . . . . 100.00 165 98.79 99.39 9.87e-115 . . . . 17461 2 71 no PDB 4DGC . "Trimcyp Cyclophilin Domain From Macaca Mulatta: Cyclosporin A Complex" . . . . . 100.00 165 98.79 99.39 9.87e-115 . . . . 17461 2 72 no PDB 4DGD . "Trimcyp Cyclophilin Domain From Macaca Mulatta: H70c Mutant" . . . . . 100.00 165 98.18 98.79 5.28e-113 . . . . 17461 2 73 no PDB 4DGE . "Trimcyp Cyclophilin Domain From Macaca Mulatta: H70c Mutant, Hiv-1 Ca(O-Loop) Complex" . . . . . 100.00 165 98.18 98.79 5.28e-113 . . . . 17461 2 74 no PDB 4IPZ . "Smbz Bound To Cyclophilin A" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 75 no PDB 5CYH . "Cyclophilin A Complexed With Dipeptide Gly-Pro" . . . . . 99.39 164 100.00 100.00 1.83e-115 . . . . 17461 2 76 no DBJ BAE01146 . "unnamed protein product [Macaca fascicularis]" . . . . . 63.64 105 99.05 100.00 1.03e-68 . . . . 17461 2 77 no DBJ BAE30323 . "unnamed protein product [Mus musculus]" . . . . . 99.39 164 96.95 97.56 6.16e-112 . . . . 17461 2 78 no DBJ BAE87660 . "unnamed protein product [Macaca fascicularis]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 79 no DBJ BAF82774 . "unnamed protein product [Homo sapiens]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 80 no DBJ BAF83540 . "unnamed protein product [Homo sapiens]" . . . . . 100.00 165 99.39 100.00 9.31e-116 . . . . 17461 2 81 no EMBL CAA34961 . "unnamed protein product [Cricetulus longicaudatus]" . . . . . 99.39 164 96.95 98.78 1.14e-112 . . . . 17461 2 82 no EMBL CAA37039 . "peptidylprolyl isomerase [Homo sapiens]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 83 no EMBL CAA68264 . "unnamed protein product [Homo sapiens]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 84 no EMBL CAG32988 . "PPIA [Homo sapiens]" . . . . . 100.00 165 99.39 100.00 8.35e-116 . . . . 17461 2 85 no EMBL CAH91833 . "hypothetical protein [Pongo abelii]" . . . . . 100.00 165 99.39 99.39 9.73e-116 . . . . 17461 2 86 no GB AAB81959 . "cyclophilin A [Papio hamadryas]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 87 no GB AAB81960 . "cyclophilin A [Chlorocebus aethiops]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 88 no GB AAB81961 . "cyclophilin A [Macaca mulatta]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 89 no GB AAF69142 . "cyclophilin I [Bos taurus]" . . . . . 56.97 94 98.94 100.00 3.84e-60 . . . . 17461 2 90 no GB AAF78600 . "cyclophilin A [Canis lupus familiaris]" . . . . . 94.55 156 98.72 100.00 3.07e-108 . . . . 17461 2 91 no PIR CSHYAC . "peptidylprolyl isomerase (EC 5.2.1.8) A - Chinese hamster" . . . . . 99.39 164 96.95 98.78 1.14e-112 . . . . 17461 2 92 no PRF 1503232A . "peptidyl-Pro cis trans isomerase" . . . . . 99.39 164 98.78 100.00 8.74e-115 . . . . 17461 2 93 no REF NP_001009370 . "peptidyl-prolyl cis-trans isomerase A [Felis catus]" . . . . . 99.39 164 96.95 98.78 1.33e-112 . . . . 17461 2 94 no REF NP_001027981 . "peptidyl-prolyl cis-trans isomerase A [Macaca mulatta]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 95 no REF NP_001126060 . "peptidyl-prolyl cis-trans isomerase A [Pongo abelii]" . . . . . 100.00 165 99.39 99.39 9.73e-116 . . . . 17461 2 96 no REF NP_001270275 . "uncharacterized protein LOC101866023 [Macaca fascicularis]" . . . . . 63.64 105 99.05 100.00 1.03e-68 . . . . 17461 2 97 no REF NP_001271703 . "uncharacterized protein LOC101925040 [Macaca fascicularis]" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 98 no SP P14851 . "RecName: Full=Peptidyl-prolyl cis-trans isomerase A; Short=PPIase A; AltName: Full=Cyclophilin A; AltName: Full=Cyclosporin A-b" . . . . . 99.39 164 96.95 98.78 1.14e-112 . . . . 17461 2 99 no SP P62935 . "RecName: Full=Peptidyl-prolyl cis-trans isomerase A; Short=PPIase A; AltName: Full=Cyclophilin A; AltName: Full=Cyclosporin A-b" . . . . . 99.39 164 98.78 100.00 8.74e-115 . . . . 17461 2 100 no SP P62936 . "RecName: Full=Peptidyl-prolyl cis-trans isomerase A; Short=PPIase A; AltName: Full=Cyclophilin A; AltName: Full=Cyclosporin A-b" . . . . . 99.39 164 98.78 100.00 8.74e-115 . . . . 17461 2 101 no SP P62937 . "RecName: Full=Peptidyl-prolyl cis-trans isomerase A; Short=PPIase A; AltName: Full=Cyclophilin A; AltName: Full=Cyclosporin A-b" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 102 no SP P62938 . "RecName: Full=Peptidyl-prolyl cis-trans isomerase A; Short=PPIase A; AltName: Full=Cyclophilin A; AltName: Full=Cyclosporin A-b" . . . . . 100.00 165 100.00 100.00 2.43e-116 . . . . 17461 2 103 no TPG DAA25853 . "TPA: TRIM5/cyclophilin A fusion protein-like [Bos taurus]" . . . . . 99.39 164 97.56 98.78 3.22e-113 . . . . 17461 2 104 no TPG DAA25854 . "TPA: TRIM5/cyclophilin A fusion protein-like [Bos taurus]" . . . . . 99.39 164 97.56 98.78 3.22e-113 . . . . 17461 2 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . MET . 17461 2 2 . VAL . 17461 2 3 . ASN . 17461 2 4 . PRO . 17461 2 5 . THR . 17461 2 6 . VAL . 17461 2 7 . PHE . 17461 2 8 . PHE . 17461 2 9 . ASP . 17461 2 10 . ILE . 17461 2 11 . ALA . 17461 2 12 . VAL . 17461 2 13 . ASP . 17461 2 14 . GLY . 17461 2 15 . GLU . 17461 2 16 . PRO . 17461 2 17 . LEU . 17461 2 18 . GLY . 17461 2 19 . ARG . 17461 2 20 . VAL . 17461 2 21 . SER . 17461 2 22 . PHE . 17461 2 23 . GLU . 17461 2 24 . LEU . 17461 2 25 . PHE . 17461 2 26 . ALA . 17461 2 27 . ASP . 17461 2 28 . LYS . 17461 2 29 . VAL . 17461 2 30 . PRO . 17461 2 31 . LYS . 17461 2 32 . THR . 17461 2 33 . ALA . 17461 2 34 . GLU . 17461 2 35 . ASN . 17461 2 36 . PHE . 17461 2 37 . ARG . 17461 2 38 . ALA . 17461 2 39 . LEU . 17461 2 40 . SER . 17461 2 41 . THR . 17461 2 42 . GLY . 17461 2 43 . GLU . 17461 2 44 . LYS . 17461 2 45 . GLY . 17461 2 46 . PHE . 17461 2 47 . GLY . 17461 2 48 . TYR . 17461 2 49 . LYS . 17461 2 50 . GLY . 17461 2 51 . SER . 17461 2 52 . CYS . 17461 2 53 . PHE . 17461 2 54 . HIS . 17461 2 55 . ARG . 17461 2 56 . ILE . 17461 2 57 . ILE . 17461 2 58 . PRO . 17461 2 59 . GLY . 17461 2 60 . PHE . 17461 2 61 . MET . 17461 2 62 . CYS . 17461 2 63 . GLN . 17461 2 64 . GLY . 17461 2 65 . GLY . 17461 2 66 . ASP . 17461 2 67 . PHE . 17461 2 68 . THR . 17461 2 69 . ARG . 17461 2 70 . HIS . 17461 2 71 . ASN . 17461 2 72 . GLY . 17461 2 73 . THR . 17461 2 74 . GLY . 17461 2 75 . GLY . 17461 2 76 . LYS . 17461 2 77 . SER . 17461 2 78 . ILE . 17461 2 79 . TYR . 17461 2 80 . GLY . 17461 2 81 . GLU . 17461 2 82 . LYS . 17461 2 83 . PHE . 17461 2 84 . GLU . 17461 2 85 . ASP . 17461 2 86 . GLU . 17461 2 87 . ASN . 17461 2 88 . PHE . 17461 2 89 . ILE . 17461 2 90 . LEU . 17461 2 91 . LYS . 17461 2 92 . HIS . 17461 2 93 . THR . 17461 2 94 . GLY . 17461 2 95 . PRO . 17461 2 96 . GLY . 17461 2 97 . ILE . 17461 2 98 . LEU . 17461 2 99 . SER . 17461 2 100 . MET . 17461 2 101 . ALA . 17461 2 102 . ASN . 17461 2 103 . ALA . 17461 2 104 . GLY . 17461 2 105 . PRO . 17461 2 106 . ASN . 17461 2 107 . THR . 17461 2 108 . ASN . 17461 2 109 . GLY . 17461 2 110 . SER . 17461 2 111 . GLN . 17461 2 112 . PHE . 17461 2 113 . PHE . 17461 2 114 . ILE . 17461 2 115 . CYS . 17461 2 116 . THR . 17461 2 117 . ALA . 17461 2 118 . LYS . 17461 2 119 . THR . 17461 2 120 . GLU . 17461 2 121 . TRP . 17461 2 122 . LEU . 17461 2 123 . ASP . 17461 2 124 . GLY . 17461 2 125 . LYS . 17461 2 126 . HIS . 17461 2 127 . VAL . 17461 2 128 . VAL . 17461 2 129 . PHE . 17461 2 130 . GLY . 17461 2 131 . LYS . 17461 2 132 . VAL . 17461 2 133 . LYS . 17461 2 134 . GLU . 17461 2 135 . GLY . 17461 2 136 . MET . 17461 2 137 . ASN . 17461 2 138 . ILE . 17461 2 139 . VAL . 17461 2 140 . GLU . 17461 2 141 . ALA . 17461 2 142 . MET . 17461 2 143 . GLU . 17461 2 144 . ARG . 17461 2 145 . PHE . 17461 2 146 . GLY . 17461 2 147 . SER . 17461 2 148 . ARG . 17461 2 149 . ASN . 17461 2 150 . GLY . 17461 2 151 . LYS . 17461 2 152 . THR . 17461 2 153 . SER . 17461 2 154 . LYS . 17461 2 155 . LYS . 17461 2 156 . ILE . 17461 2 157 . THR . 17461 2 158 . ILE . 17461 2 159 . ALA . 17461 2 160 . ASP . 17461 2 161 . CYS . 17461 2 162 . GLY . 17461 2 163 . GLN . 17461 2 164 . LEU . 17461 2 165 . GLU . 17461 2 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . MET 1 1 17461 2 . VAL 2 2 17461 2 . ASN 3 3 17461 2 . PRO 4 4 17461 2 . THR 5 5 17461 2 . VAL 6 6 17461 2 . PHE 7 7 17461 2 . PHE 8 8 17461 2 . ASP 9 9 17461 2 . ILE 10 10 17461 2 . ALA 11 11 17461 2 . VAL 12 12 17461 2 . ASP 13 13 17461 2 . GLY 14 14 17461 2 . GLU 15 15 17461 2 . PRO 16 16 17461 2 . LEU 17 17 17461 2 . GLY 18 18 17461 2 . ARG 19 19 17461 2 . VAL 20 20 17461 2 . SER 21 21 17461 2 . PHE 22 22 17461 2 . GLU 23 23 17461 2 . LEU 24 24 17461 2 . PHE 25 25 17461 2 . ALA 26 26 17461 2 . ASP 27 27 17461 2 . LYS 28 28 17461 2 . VAL 29 29 17461 2 . PRO 30 30 17461 2 . LYS 31 31 17461 2 . THR 32 32 17461 2 . ALA 33 33 17461 2 . GLU 34 34 17461 2 . ASN 35 35 17461 2 . PHE 36 36 17461 2 . ARG 37 37 17461 2 . ALA 38 38 17461 2 . LEU 39 39 17461 2 . SER 40 40 17461 2 . THR 41 41 17461 2 . GLY 42 42 17461 2 . GLU 43 43 17461 2 . LYS 44 44 17461 2 . GLY 45 45 17461 2 . PHE 46 46 17461 2 . GLY 47 47 17461 2 . TYR 48 48 17461 2 . LYS 49 49 17461 2 . GLY 50 50 17461 2 . SER 51 51 17461 2 . CYS 52 52 17461 2 . PHE 53 53 17461 2 . HIS 54 54 17461 2 . ARG 55 55 17461 2 . ILE 56 56 17461 2 . ILE 57 57 17461 2 . PRO 58 58 17461 2 . GLY 59 59 17461 2 . PHE 60 60 17461 2 . MET 61 61 17461 2 . CYS 62 62 17461 2 . GLN 63 63 17461 2 . GLY 64 64 17461 2 . GLY 65 65 17461 2 . ASP 66 66 17461 2 . PHE 67 67 17461 2 . THR 68 68 17461 2 . ARG 69 69 17461 2 . HIS 70 70 17461 2 . ASN 71 71 17461 2 . GLY 72 72 17461 2 . THR 73 73 17461 2 . GLY 74 74 17461 2 . GLY 75 75 17461 2 . LYS 76 76 17461 2 . SER 77 77 17461 2 . ILE 78 78 17461 2 . TYR 79 79 17461 2 . GLY 80 80 17461 2 . GLU 81 81 17461 2 . LYS 82 82 17461 2 . PHE 83 83 17461 2 . GLU 84 84 17461 2 . ASP 85 85 17461 2 . GLU 86 86 17461 2 . ASN 87 87 17461 2 . PHE 88 88 17461 2 . ILE 89 89 17461 2 . LEU 90 90 17461 2 . LYS 91 91 17461 2 . HIS 92 92 17461 2 . THR 93 93 17461 2 . GLY 94 94 17461 2 . PRO 95 95 17461 2 . GLY 96 96 17461 2 . ILE 97 97 17461 2 . LEU 98 98 17461 2 . SER 99 99 17461 2 . MET 100 100 17461 2 . ALA 101 101 17461 2 . ASN 102 102 17461 2 . ALA 103 103 17461 2 . GLY 104 104 17461 2 . PRO 105 105 17461 2 . ASN 106 106 17461 2 . THR 107 107 17461 2 . ASN 108 108 17461 2 . GLY 109 109 17461 2 . SER 110 110 17461 2 . GLN 111 111 17461 2 . PHE 112 112 17461 2 . PHE 113 113 17461 2 . ILE 114 114 17461 2 . CYS 115 115 17461 2 . THR 116 116 17461 2 . ALA 117 117 17461 2 . LYS 118 118 17461 2 . THR 119 119 17461 2 . GLU 120 120 17461 2 . TRP 121 121 17461 2 . LEU 122 122 17461 2 . ASP 123 123 17461 2 . GLY 124 124 17461 2 . LYS 125 125 17461 2 . HIS 126 126 17461 2 . VAL 127 127 17461 2 . VAL 128 128 17461 2 . PHE 129 129 17461 2 . GLY 130 130 17461 2 . LYS 131 131 17461 2 . VAL 132 132 17461 2 . LYS 133 133 17461 2 . GLU 134 134 17461 2 . GLY 135 135 17461 2 . MET 136 136 17461 2 . ASN 137 137 17461 2 . ILE 138 138 17461 2 . VAL 139 139 17461 2 . GLU 140 140 17461 2 . ALA 141 141 17461 2 . MET 142 142 17461 2 . GLU 143 143 17461 2 . ARG 144 144 17461 2 . PHE 145 145 17461 2 . GLY 146 146 17461 2 . SER 147 147 17461 2 . ARG 148 148 17461 2 . ASN 149 149 17461 2 . GLY 150 150 17461 2 . LYS 151 151 17461 2 . THR 152 152 17461 2 . SER 153 153 17461 2 . LYS 154 154 17461 2 . LYS 155 155 17461 2 . ILE 156 156 17461 2 . THR 157 157 17461 2 . ILE 158 158 17461 2 . ALA 159 159 17461 2 . ASP 160 160 17461 2 . CYS 161 161 17461 2 . GLY 162 162 17461 2 . GLN 163 163 17461 2 . LEU 164 164 17461 2 . GLU 165 165 17461 2 stop_ save_ #################### # Natural source # #################### save_natural_source _Entity_natural_src_list.Sf_category natural_source _Entity_natural_src_list.Sf_framecode natural_source _Entity_natural_src_list.Entry_ID 17461 _Entity_natural_src_list.ID 1 loop_ _Entity_natural_src.ID _Entity_natural_src.Entity_ID _Entity_natural_src.Entity_label _Entity_natural_src.Entity_chimera_segment_ID _Entity_natural_src.NCBI_taxonomy_ID _Entity_natural_src.Type _Entity_natural_src.Common _Entity_natural_src.Organism_name_scientific _Entity_natural_src.Organism_name_common _Entity_natural_src.Organism_acronym _Entity_natural_src.ICTVdb_decimal_code _Entity_natural_src.Superkingdom _Entity_natural_src.Kingdom _Entity_natural_src.Genus _Entity_natural_src.Species _Entity_natural_src.Strain _Entity_natural_src.Variant _Entity_natural_src.Subvariant _Entity_natural_src.Organ _Entity_natural_src.Tissue _Entity_natural_src.Tissue_fraction _Entity_natural_src.Cell_line _Entity_natural_src.Cell_type _Entity_natural_src.ATCC_number _Entity_natural_src.Organelle _Entity_natural_src.Cellular_location _Entity_natural_src.Fragment _Entity_natural_src.Fraction _Entity_natural_src.Secretion _Entity_natural_src.Plasmid _Entity_natural_src.Plasmid_details _Entity_natural_src.Gene_mnemonic _Entity_natural_src.Dev_stage _Entity_natural_src.Details _Entity_natural_src.Citation_ID _Entity_natural_src.Citation_label _Entity_natural_src.Entry_ID _Entity_natural_src.Entity_natural_src_list_ID 1 1 $GroEL . 562 organism . 'Escherichia coli' 'E. coli' . . Bacteria . Escherichia coli . . . . . . . . . . . . . . . . . . . . . 17461 1 2 2 $CypA . 9606 organism . 'Homo sapiens' human . . Eukaryota Metazoa Homo sapiens . . . . . . . . . . . . . . . . . . . . . 17461 1 stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Entity_experimental_src_list.Sf_category experimental_source _Entity_experimental_src_list.Sf_framecode experimental_source _Entity_experimental_src_list.Entry_ID 17461 _Entity_experimental_src_list.ID 1 loop_ _Entity_experimental_src.ID _Entity_experimental_src.Entity_ID _Entity_experimental_src.Entity_label _Entity_experimental_src.Entity_chimera_segment_ID _Entity_experimental_src.Production_method _Entity_experimental_src.Host_org_scientific_name _Entity_experimental_src.Host_org_name_common _Entity_experimental_src.Host_org_details _Entity_experimental_src.Host_org_NCBI_taxonomy_ID _Entity_experimental_src.Host_org_genus _Entity_experimental_src.Host_org_species _Entity_experimental_src.Host_org_strain _Entity_experimental_src.Host_org_variant _Entity_experimental_src.Host_org_subvariant _Entity_experimental_src.Host_org_organ _Entity_experimental_src.Host_org_tissue _Entity_experimental_src.Host_org_tissue_fraction _Entity_experimental_src.Host_org_cell_line _Entity_experimental_src.Host_org_cell_type _Entity_experimental_src.Host_org_cellular_location _Entity_experimental_src.Host_org_organelle _Entity_experimental_src.Host_org_gene _Entity_experimental_src.Host_org_culture_collection _Entity_experimental_src.Host_org_ATCC_number _Entity_experimental_src.Vector_type _Entity_experimental_src.PDBview_host_org_vector_name _Entity_experimental_src.PDBview_plasmid_name _Entity_experimental_src.Vector_name _Entity_experimental_src.Vector_details _Entity_experimental_src.Vendor_name _Entity_experimental_src.Host_org_dev_stage _Entity_experimental_src.Details _Entity_experimental_src.Citation_ID _Entity_experimental_src.Citation_label _Entity_experimental_src.Entry_ID _Entity_experimental_src.Entity_experimental_src_list_ID 1 1 $GroEL . 'recombinant technology' 'Escherichia coli' . . . Escherichia coli W3110 . . . . . . . . . . . . . . . pOF39 . . . . . . 17461 1 2 2 $CypA . 'recombinant technology' 'Escherichia coli' . . . Escherichia coli . . . . . . . . . . . . . . . . ns . . . . . . 17461 1 stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Sample.Sf_category sample _Sample.Sf_framecode sample_1 _Sample.Entry_ID 17461 _Sample.ID 1 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'CypA bound to GroEL' _Sample.Aggregate_sample_number . _Sample.Solvent_system '90% H2O/10% D2O' _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 CypA '[U-100% 15N]' . . 2 $CypA . . . 150 300 uM . . . . 17461 1 2 GroEL 'natural abundance' . . 1 $GroEL . . . 150 300 uM . . . . 17461 1 3 H2O 'natural abundance' . . . . . . 90 . . % . . . . 17461 1 4 D2O 'natural abundance' . . . . . . 10 . . % . . . . 17461 1 stop_ save_ save_sample_2 _Sample.Sf_category sample _Sample.Sf_framecode sample_2 _Sample.Entry_ID 17461 _Sample.ID 2 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'refolding; CypA bound to GroEL' _Sample.Aggregate_sample_number . _Sample.Solvent_system H2O _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 CypA '[U-100% 15N]' . . 2 $CypA . . 1 . . uM . . . . 17461 2 2 GroEL 'natural abundance' . . 1 $GroEL . . 1 . . uM . . . . 17461 2 3 MES 'natural abundance' . . . . . . 1 . . mM . . . . 17461 2 4 DTT 'natural abundance' . . . . . . 0.05 . . mM . . . . 17461 2 5 H2O 'natural abundance' . . . . . . 100 . . % . . . . 17461 2 stop_ save_ save_sample_3 _Sample.Sf_category sample _Sample.Sf_framecode sample_3 _Sample.Entry_ID 17461 _Sample.ID 3 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'refolding; CypA bound to GroEL' _Sample.Aggregate_sample_number . _Sample.Solvent_system H2O _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 CypA '[U-100% 15N]' . . 2 $CypA . . 1 . . uM . . . . 17461 3 2 GroEL 'natural abundance' . . 1 $GroEL . . 1 . . uM . . . . 17461 3 3 MES 'natural abundance' . . . . . . 1 . . mM . . . . 17461 3 4 DTT 'natural abundance' . . . . . . 0.05 . . mM . . . . 17461 3 5 'potassium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 3 6 'magnesium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 3 7 ADP 'natural abundance' . . . . . . 1 . . mM . . . . 17461 3 8 H2O 'natural abundance' . . . . . . 100 . . % . . . . 17461 3 stop_ save_ save_sample_4 _Sample.Sf_category sample _Sample.Sf_framecode sample_4 _Sample.Entry_ID 17461 _Sample.ID 4 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'refolding; CypA bound to GroEL' _Sample.Aggregate_sample_number . _Sample.Solvent_system H2O _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 CypA '[U-100% 15N]' . . 2 $CypA . . 1 . . uM . . . . 17461 4 2 GroEL 'natural abundance' . . 1 $GroEL . . 1 . . uM . . . . 17461 4 3 MES 'natural abundance' . . . . . . 1 . . mM . . . . 17461 4 4 DTT 'natural abundance' . . . . . . 0.05 . . mM . . . . 17461 4 5 'potassium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 4 6 'magnesium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 4 7 ATP 'natural abundance' . . . . . . 1 . . mM . . . . 17461 4 8 H2O 'natural abundance' . . . . . . 100 . . % . . . . 17461 4 stop_ save_ save_sample_5 _Sample.Sf_category sample _Sample.Sf_framecode sample_5 _Sample.Entry_ID 17461 _Sample.ID 5 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'refolding; CypA bound to GroEL' _Sample.Aggregate_sample_number . _Sample.Solvent_system H2O _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 CypA '[U-100% 15N]' . . 2 $CypA . . 1 . . uM . . . . 17461 5 2 GroEL 'natural abundance' . . 1 $GroEL . . 1 . . uM . . . . 17461 5 3 MES 'natural abundance' . . . . . . 1 . . mM . . . . 17461 5 4 DTT 'natural abundance' . . . . . . 0.05 . . mM . . . . 17461 5 5 'potassium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 5 6 'magnesium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 5 7 ADP 'natural abundance' . . . . . . 1 . . mM . . . . 17461 5 8 GroES 'natural abundance' . . . . . . 2 . . uM . . . . 17461 5 9 H2O 'natural abundance' . . . . . . 100 . . % . . . . 17461 5 stop_ save_ save_sample_6 _Sample.Sf_category sample _Sample.Sf_framecode sample_6 _Sample.Entry_ID 17461 _Sample.ID 6 _Sample.Type solution _Sample.Sub_type . _Sample.Details 'refolding; CypA bound to GroEL' _Sample.Aggregate_sample_number . _Sample.Solvent_system H2O _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 CypA '[U-100% 15N]' . . 2 $CypA . . 1 . . uM . . . . 17461 6 2 GroEL 'natural abundance' . . 1 $GroEL . . 1 . . uM . . . . 17461 6 3 MES 'natural abundance' . . . . . . 1 . . mM . . . . 17461 6 4 DTT 'natural abundance' . . . . . . 0.05 . . mM . . . . 17461 6 5 'potassium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 6 6 'magnesium chloride' 'natural abundance' . . . . . . 2 . . mM . . . . 17461 6 7 ATP 'natural abundance' . . . . . . 1 . . mM . . . . 17461 6 8 GroES 'natural abundance' . . . . . . 2 . . uM . . . . 17461 6 9 H2O 'natural abundance' . . . . . . 100 . . % . . . . 17461 6 stop_ save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_1 _Sample_condition_list.Entry_ID 17461 _Sample_condition_list.ID 1 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 6.0 . pH 17461 1 pressure 1 . atm 17461 1 temperature 299 . K 17461 1 stop_ save_ save_sample_conditions_2 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_2 _Sample_condition_list.Entry_ID 17461 _Sample_condition_list.ID 2 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 6.0 . pH 17461 2 pressure 1 . atm 17461 2 temperature 279 . K 17461 2 stop_ save_ save_sample_conditions_3 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_3 _Sample_condition_list.Entry_ID 17461 _Sample_condition_list.ID 3 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 6.0 . pH 17461 3 pressure 1 . atm 17461 3 temperature 289 . K 17461 3 stop_ save_ save_sample_conditions_4 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_4 _Sample_condition_list.Entry_ID 17461 _Sample_condition_list.ID 4 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 6.0 . pH 17461 4 pressure 1 . atm 17461 4 temperature 303 . K 17461 4 stop_ save_ ############################ # Computer software used # ############################ save_PROSA _Software.Sf_category software _Software.Sf_framecode PROSA _Software.Entry_ID 17461 _Software.ID 1 _Software.Name PROSA _Software.Version . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID Guntert . . 17461 1 stop_ loop_ _Task.Task _Task.Entry_ID _Task.Software_ID 'data analysis' 17461 1 processing 17461 1 stop_ save_ save_XEASY _Software.Sf_category software _Software.Sf_framecode XEASY _Software.Entry_ID 17461 _Software.ID 2 _Software.Name XEASY _Software.Version . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID 'Bartels et al.' . . 17461 2 stop_ loop_ _Task.Task _Task.Entry_ID _Task.Software_ID 'data analysis' 17461 2 processing 17461 2 stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _NMR_spectrometer.Sf_category NMR_spectrometer _NMR_spectrometer.Sf_framecode spectrometer_1 _NMR_spectrometer.Entry_ID 17461 _NMR_spectrometer.ID 1 _NMR_spectrometer.Details . _NMR_spectrometer.Manufacturer Bruker _NMR_spectrometer.Model AMX _NMR_spectrometer.Serial_number . _NMR_spectrometer.Field_strength 600 save_ save_NMR_spectrometer_list _NMR_spectrometer_list.Sf_category NMR_spectrometer_list _NMR_spectrometer_list.Sf_framecode NMR_spectrometer_list _NMR_spectrometer_list.Entry_ID 17461 _NMR_spectrometer_list.ID 1 loop_ _NMR_spectrometer_view.ID _NMR_spectrometer_view.Name _NMR_spectrometer_view.Manufacturer _NMR_spectrometer_view.Model _NMR_spectrometer_view.Serial_number _NMR_spectrometer_view.Field_strength _NMR_spectrometer_view.Details _NMR_spectrometer_view.Citation_ID _NMR_spectrometer_view.Citation_label _NMR_spectrometer_view.Entry_ID _NMR_spectrometer_view.NMR_spectrometer_list_ID 1 spectrometer_1 Bruker AMX . 600 . . . 17461 1 stop_ save_ ############################# # NMR applied experiments # ############################# save_experiment_list _Experiment_list.Sf_category experiment_list _Experiment_list.Sf_framecode experiment_list _Experiment_list.Entry_ID 17461 _Experiment_list.ID 1 _Experiment_list.Details . loop_ _Experiment.ID _Experiment.Name _Experiment.Raw_data_flag _Experiment.NMR_spec_expt_ID _Experiment.NMR_spec_expt_label _Experiment.MS_expt_ID _Experiment.MS_expt_label _Experiment.SAXS_expt_ID _Experiment.SAXS_expt_label _Experiment.FRET_expt_ID _Experiment.FRET_expt_label _Experiment.EMR_expt_ID _Experiment.EMR_expt_label _Experiment.Sample_ID _Experiment.Sample_label _Experiment.Sample_state _Experiment.Sample_volume _Experiment.Sample_volume_units _Experiment.Sample_condition_list_ID _Experiment.Sample_condition_list_label _Experiment.Sample_spinning_rate _Experiment.Sample_angle _Experiment.NMR_tube_type _Experiment.NMR_spectrometer_ID _Experiment.NMR_spectrometer_label _Experiment.NMR_spectrometer_probe_ID _Experiment.NMR_spectrometer_probe_label _Experiment.NMR_spectral_processing_ID _Experiment.NMR_spectral_processing_label _Experiment.Mass_spectrometer_ID _Experiment.Mass_spectrometer_label _Experiment.Xray_instrument_ID _Experiment.Xray_instrument_label _Experiment.Fluorescence_instrument_ID _Experiment.Fluorescence_instrument_label _Experiment.EMR_instrument_ID _Experiment.EMR_instrument_label _Experiment.Chromatographic_system_ID _Experiment.Chromatographic_system_label _Experiment.Chromatographic_column_ID _Experiment.Chromatographic_column_label _Experiment.Entry_ID _Experiment.Experiment_list_ID 1 '2D 1H-15N HSQC' no . . . . . . . . . . 1 $sample_1 isotropic . . 1 $sample_conditions_1 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 2 '2D 1H-15N HSQC' no . . . . . . . . . . 2 $sample_2 isotropic . . 2 $sample_conditions_2 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 3 '2D 1H-15N HSQC' no . . . . . . . . . . 3 $sample_3 isotropic . . 2 $sample_conditions_2 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 4 '2D 1H-15N HSQC' no . . . . . . . . . . 4 $sample_4 isotropic . . 2 $sample_conditions_2 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 5 '2D 1H-15N HSQC' no . . . . . . . . . . 5 $sample_5 isotropic . . 2 $sample_conditions_2 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 6 '2D 1H-15N HSQC' no . . . . . . . . . . 6 $sample_6 isotropic . . 2 $sample_conditions_2 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 7 '2D 1H-15N HSQC' no . . . . . . . . . . 5 $sample_5 isotropic . . 3 $sample_conditions_3 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 8 '2D 1H-15N HSQC' no . . . . . . . . . . 5 $sample_5 isotropic . . 4 $sample_conditions_4 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 9 '2D 1H-15N HSQC' no . . . . . . . . . . 6 $sample_6 isotropic . . 4 $sample_conditions_4 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17461 1 stop_ save_ save_Chemical_rate_list_1 _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list_1 _Chemical_rate_list.Entry_ID 17461 _Chemical_rate_list.ID 1 _Chemical_rate_list.Sample_condition_list_ID 1 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_1 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 1 '2D 1H-15N HSQC' 1 $sample_1 isotropic 17461 1 stop_ loop_ _Chemical_rate_software.Software_ID _Chemical_rate_software.Software_label _Chemical_rate_software.Method_ID _Chemical_rate_software.Method_label _Chemical_rate_software.Entry_ID _Chemical_rate_software.Chemical_rate_list_ID 1 $PROSA . . 17461 1 2 $XEASY . . 17461 1 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 . . . . . . 'EL rate constant' . 0.1 1.0 . min-1 . . . . . 17461 1 2 1 . 1 1 . . . . . . 'Protection factor' . 1000 100000 . . . . . . . 17461 1 3 1 . 1 1 . . . . . . 'deProtection factor' . 1000 100000 . . . . . . . 17461 1 stop_ save_ save_Chemical_rate_list_2 _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list_2 _Chemical_rate_list.Entry_ID 17461 _Chemical_rate_list.ID 2 _Chemical_rate_list.Sample_condition_list_ID 2 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_2 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 2 '2D 1H-15N HSQC' 2 $sample_2 isotropic 17461 2 3 '2D 1H-15N HSQC' 3 $sample_3 isotropic 17461 2 4 '2D 1H-15N HSQC' 4 $sample_4 isotropic 17461 2 5 '2D 1H-15N HSQC' 5 $sample_5 isotropic 17461 2 6 '2D 1H-15N HSQC' 6 $sample_6 isotropic 17461 2 stop_ loop_ _Chemical_rate_software.Software_ID _Chemical_rate_software.Software_label _Chemical_rate_software.Method_ID _Chemical_rate_software.Method_label _Chemical_rate_software.Entry_ID _Chemical_rate_software.Chemical_rate_list_ID 1 $PROSA . . 17461 2 2 $XEASY . . 17461 2 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 . . . . . . 'rate constant' 0.0014 . . 0.0003 min-1 . . . . . 17461 2 2 1 . 1 1 . . . . . . 'rate constant' 0.0035 . . 0.0007 min-1 . . . . . 17461 2 3 1 . 1 1 . . . . . . 'rate constant' 0.0048 . . 0.0007 min-1 . . . . . 17461 2 4 1 . 1 1 . . . . . . 'rate constant' 0.021 . . 0.001 min-1 . . . . . 17461 2 5 1 . 1 1 . . . . . . 'rate constant' 0.020 . . 0.001 min-1 . . . . . 17461 2 stop_ save_ save_Chemical_rate_list_3 _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list_3 _Chemical_rate_list.Entry_ID 17461 _Chemical_rate_list.ID 3 _Chemical_rate_list.Sample_condition_list_ID 3 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_3 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 7 '2D 1H-15N HSQC' 5 $sample_5 isotropic 17461 3 stop_ loop_ _Chemical_rate_software.Software_ID _Chemical_rate_software.Software_label _Chemical_rate_software.Method_ID _Chemical_rate_software.Method_label _Chemical_rate_software.Entry_ID _Chemical_rate_software.Chemical_rate_list_ID 1 $PROSA . . 17461 3 2 $XEASY . . 17461 3 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 . . . . . . 'rate constant' 0.057 . . 0.003 min-1 . . . . . 17461 3 stop_ save_ save_Chemical_rate_list_4 _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list_4 _Chemical_rate_list.Entry_ID 17461 _Chemical_rate_list.ID 4 _Chemical_rate_list.Sample_condition_list_ID 4 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_4 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 8 '2D 1H-15N HSQC' 5 $sample_5 isotropic 17461 4 9 '2D 1H-15N HSQC' 6 $sample_6 isotropic 17461 4 stop_ loop_ _Chemical_rate_software.Software_ID _Chemical_rate_software.Software_label _Chemical_rate_software.Method_ID _Chemical_rate_software.Method_label _Chemical_rate_software.Entry_ID _Chemical_rate_software.Chemical_rate_list_ID 1 $PROSA . . 17461 4 2 $XEASY . . 17461 4 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 . . . . . . 'rate constant' 0.56 . . 0.05 min-1 . . . . . 17461 4 2 1 . 1 1 . . . . . . 'rate constant' 0.72 . . 0.05 min-1 . . . . . 17461 4 stop_ save_