data_17464 ####################### # Entry information # ####################### save_entry_information _Entry.Sf_category entry_information _Entry.Sf_framecode entry_information _Entry.ID 17464 _Entry.Title ; Solution Structure of Acidic Fibroblast Growth Factor Bound to 1,3,6-Naphthalenetrisulfonate: A Minimal Model for the Anti-tumoral Action of Suramins and Suradistas ; _Entry.Type macromolecule _Entry.Version_type original _Entry.Submission_date 2011-02-11 _Entry.Accession_date 2011-02-11 _Entry.Last_release_date 2012-06-06 _Entry.Original_release_date 2012-06-06 _Entry.Origination author _Entry.NMR_STAR_version 3.1.1.61 _Entry.Original_NMR_STAR_version 3.1 _Entry.Experimental_method NMR _Entry.Experimental_method_subtype solution _Entry.Details . _Entry.BMRB_internal_directory_name . loop_ _Entry_author.Ordinal _Entry_author.Given_name _Entry_author.Family_name _Entry_author.First_initial _Entry_author.Middle_initials _Entry_author.Family_title _Entry_author.Entry_ID 1 Rosa Lozano . M. . 17464 2 M. Jimenez . A. . 17464 3 Jorge Santoro . . . 17464 4 Manuel Rico . . . 17464 5 Guillermo Gimenez-Gallego . . . 17464 stop_ loop_ _Data_set.Type _Data_set.Count _Data_set.Entry_ID chemical_rates 1 17464 stop_ loop_ _Datum.Type _Datum.Count _Datum.Entry_ID 'kinetic rates' 1 17464 stop_ loop_ _Release.Release_number _Release.Format_type _Release.Format_version _Release.Date _Release.Submission_date _Release.Type _Release.Author _Release.Detail _Release.Entry_ID 1 . . 2012-06-06 2011-02-11 original author . 17464 stop_ save_ ############### # Citations # ############### save_entry_citation _Citation.Sf_category citations _Citation.Sf_framecode entry_citation _Citation.Entry_ID 17464 _Citation.ID 1 _Citation.Class 'entry citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.DOI . _Citation.PubMed_ID . _Citation.Full_citation . _Citation.Title 'Solution Structure of Acidic Fibroblast Growth Factor Bound to 1,3,6-Naphthalenetrisulfonate: A Minimal Model for the Anti-tumoral Action of Suramins and Suradistas' _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'J. Mol. Biol.' _Citation.Journal_name_full . _Citation.Journal_volume 281 _Citation.Journal_issue . _Citation.Journal_ASTM . _Citation.Journal_ISSN . _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 899 _Citation.Page_last 915 _Citation.Year 1998 _Citation.Details . loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 Rosa Lozano . M. . 17464 1 2 M. Jimenez . A. . 17464 1 3 Jorge Santoro . . . 17464 1 4 Manuel Rico . . . 17464 1 5 Guillermo Gimenez-Gallego . . . 17464 1 stop_ save_ ############################################# # Molecular system (assembly) description # ############################################# save_assembly _Assembly.Sf_category assembly _Assembly.Sf_framecode assembly _Assembly.Entry_ID 17464 _Assembly.ID 1 _Assembly.Name 'FGF/NTS complex' _Assembly.BMRB_code . _Assembly.Number_of_components 2 _Assembly.Organic_ligands . _Assembly.Metal_ions . _Assembly.Non_standard_bonds no _Assembly.Ambiguous_conformational_states . _Assembly.Ambiguous_chem_comp_sites . _Assembly.Molecules_in_chemical_exchange . _Assembly.Paramagnetic yes _Assembly.Thiol_state . _Assembly.Molecular_mass . _Assembly.Enzyme_commission_number . _Assembly.Details . _Assembly.DB_query_date . _Assembly.DB_query_revised_last_date . loop_ _Entity_assembly.ID _Entity_assembly.Entity_assembly_name _Entity_assembly.Entity_ID _Entity_assembly.Entity_label _Entity_assembly.Asym_ID _Entity_assembly.PDB_chain_ID _Entity_assembly.Experimental_data_reported _Entity_assembly.Physical_state _Entity_assembly.Conformational_isomer _Entity_assembly.Chemical_exchange_state _Entity_assembly.Magnetic_equivalence_group_code _Entity_assembly.Role _Entity_assembly.Details _Entity_assembly.Entry_ID _Entity_assembly.Assembly_ID 1 FGF 1 $FGF A . yes native no no . . . 17464 1 2 NTS 2 $NTS B . yes native no no . . . 17464 1 stop_ save_ #################################### # Biological polymers and ligands # #################################### save_FGF _Entity.Sf_category entity _Entity.Sf_framecode FGF _Entity.Entry_ID 17464 _Entity.ID 1 _Entity.BMRB_code . _Entity.Name FGF _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code ; KKPKLLYCSNGGHFLRILPD GTVDGTRDRSDQHIQLQLSA ESVGEVYIKSTETGQYLAMD TDGLLYGSQTPNEECLFLER LEENHYNTYISKKHAEKNWF VGLKKNGSCKRGPRTHYGQK AILFLPLPVSSD ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states yes _Entity.Ambiguous_chem_comp_sites yes _Entity.Nstd_monomer yes _Entity.Nstd_chirality yes _Entity.Nstd_linkage yes _Entity.Nonpolymer_comp_ID NTS _Entity.Nonpolymer_comp_label $chem_comp_NTS _Entity.Number_of_monomers 132 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic yes _Entity.Thiol_state 'not reported' _Entity.Src_method . _Entity.Parent_entity_ID 1 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight . _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date 2015-11-25 loop_ _Entity_db_link.Ordinal _Entity_db_link.Author_supplied _Entity_db_link.Database_code _Entity_db_link.Accession_code _Entity_db_link.Entry_mol_code _Entity_db_link.Entry_mol_name _Entity_db_link.Entry_experimental_method _Entity_db_link.Entry_structure_resolution _Entity_db_link.Entry_relation_type _Entity_db_link.Entry_details _Entity_db_link.Chimera_segment_ID _Entity_db_link.Seq_query_to_submitted_percent _Entity_db_link.Seq_subject_length _Entity_db_link.Seq_identity _Entity_db_link.Seq_positive _Entity_db_link.Seq_homology_expectation_val _Entity_db_link.Seq_align_begin _Entity_db_link.Seq_align_end _Entity_db_link.Seq_difference_details _Entity_db_link.Seq_alignment_details _Entity_db_link.Entry_ID _Entity_db_link.Entity_ID 1 no BMRB 15783 . FGF-1 . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 2 no BMRB 15960 . FGF-1 . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 3 no BMRB 16493 . aFGF . . . . . 100.00 132 100.00 100.00 1.76e-92 . . . . 17464 1 4 no BMRB 16494 . aFGF . . . . . 100.00 132 100.00 100.00 1.76e-92 . . . . 17464 1 5 no BMRB 16502 . aFGF . . . . . 100.00 132 100.00 100.00 1.76e-92 . . . . 17464 1 6 no BMRB 17674 . FGF1 . . . . . 97.73 130 100.00 100.00 2.70e-90 . . . . 17464 1 7 no PDB 1AXM . "Heparin-Linked Biologically-Active Dimer Of Fibroblast Growth Factor" . . . . . 100.00 135 99.24 99.24 3.99e-91 . . . . 17464 1 8 no PDB 1DJS . "Ligand-binding Portion Of Fibroblast Growth Factor Receptor 2 In Complex With Fgf1" . . . . . 100.00 135 99.24 99.24 3.99e-91 . . . . 17464 1 9 no PDB 1DZC . "High Resolution Structure Of Acidic Fibroblast Growth Factor. Mutant Fgf-4-ala-(23-154), 24 Nmr Structures" . . . . . 96.97 131 100.00 100.00 9.08e-90 . . . . 17464 1 10 no PDB 1DZD . "High Resolution Structure Of Acidic Fibroblast Growth Factor (27-154), 24 Nmr Structures" . . . . . 96.21 127 100.00 100.00 7.31e-89 . . . . 17464 1 11 no PDB 1E0O . "Crystal Structure Of A Ternary Fgf1-Fgfr2-Heparin Complex" . . . . . 100.00 140 100.00 100.00 5.30e-92 . . . . 17464 1 12 no PDB 1EVT . "Crystal Structure Of Fgf1 In Complex With The Extracellular Ligand Binding Domain Of Fgf Receptor 1 (Fgfr1)" . . . . . 100.00 134 100.00 100.00 1.92e-92 . . . . 17464 1 13 no PDB 1HKN . "A Complex Between Acidic Fibroblast Growth Factor And 5- Amino-2-Naphthalenesulfonate" . . . . . 100.00 139 100.00 100.00 4.80e-92 . . . . 17464 1 14 no PDB 1JQZ . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag." . . . . . 100.00 146 100.00 100.00 9.59e-92 . . . . 17464 1 15 no PDB 1JT3 . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Histidine Tag And Leu 73 Replaced By Val (L73v)" . . . . . 100.00 146 99.24 100.00 1.85e-91 . . . . 17464 1 16 no PDB 1JT4 . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag And Val 109 Replaced By Leu (v109l)" . . . . . 100.00 146 99.24 100.00 3.19e-91 . . . . 17464 1 17 no PDB 1JT5 . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag And Leu 73 Replaced By Val And Val 109 R" . . . . . 100.00 146 98.48 100.00 8.42e-91 . . . . 17464 1 18 no PDB 1JT7 . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag And Leu 44 Replaced By Phe And Leu 73 Re" . . . . . 100.00 146 97.73 99.24 2.33e-90 . . . . 17464 1 19 no PDB 1JTC . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag And Leu 44 Replaced By Phe (L44f)" . . . . . 100.00 146 99.24 99.24 2.62e-91 . . . . 17464 1 20 no PDB 1JY0 . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag And Cys 117 Replaced With Val (C117v)" . . . . . 100.00 146 99.24 99.24 8.06e-91 . . . . 17464 1 21 no PDB 1K5U . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag With His93 Replaced By Gly (H93g)" . . . . . 100.00 146 99.24 99.24 2.83e-90 . . . . 17464 1 22 no PDB 1K5V . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag With Asn106 Replaced By Gly (N106g)" . . . . . 100.00 146 99.24 99.24 9.60e-91 . . . . 17464 1 23 no PDB 1M16 . "Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form With Amino Terminal His Tag And Leu 44 Replaced With Phe (L44f), Leu" . . . . . 100.00 146 96.97 98.48 2.28e-89 . . . . 17464 1 24 no PDB 1P63 . "Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form With Amino Terminal His Tag And Leu111 Replaced With Ile (L111i)" . . . . . 100.00 144 99.24 100.00 1.71e-91 . . . . 17464 1 25 no PDB 1PZZ . "Crystal Structure Of Fgf-1, V51n Mutant" . . . . . 100.00 146 99.24 99.24 1.14e-90 . . . . 17464 1 26 no PDB 1Q03 . "Crystal Structure Of Fgf-1, S50gV51G MUTANT" . . . . . 100.00 146 98.48 98.48 7.81e-90 . . . . 17464 1 27 no PDB 1Q04 . "Crystal Structure Of Fgf-1, S50e/v51n" . . . . . 100.00 146 98.48 98.48 4.19e-90 . . . . 17464 1 28 no PDB 1RG8 . "Human Acidic Fibroblast Growth Factor (Hafgf-1) At 1.10 Angstrom Resolution (140 Amino Acid Form)" . . . . . 100.00 146 100.00 100.00 9.59e-92 . . . . 17464 1 29 no PDB 1RML . "Nmr Study Of Acid Fibroblast Growth Factor Bound To 1,3,6- Naphthalene Trisulphonate, 26 Structures" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 30 no PDB 1RY7 . "Crystal Structure Of The 3 Ig Form Of Fgfr3c In Complex With Fgf1" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 31 no PDB 1YTO . "Crystal Structure Of Gly19 Deletion Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 145 99.24 99.24 4.02e-89 . . . . 17464 1 32 no PDB 1Z2V . "Crystal Structure Of Glu60 Deletion Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 145 99.24 99.24 3.34e-89 . . . . 17464 1 33 no PDB 1Z4S . "Crystal Structure Of Gly19 And Glu60 Deletion Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 144 98.48 98.48 1.12e-86 . . . . 17464 1 34 no PDB 2AFG . "2.0 Angstrom X-Ray Structure Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 140 100.00 100.00 5.30e-92 . . . . 17464 1 35 no PDB 2AQZ . "Crystal Structure Of Fgf-1, S17tN18TG19 DELETION MUTANT" . . . . . 100.00 145 97.73 98.48 4.79e-88 . . . . 17464 1 36 no PDB 2AXM . "Heparin-Linked Biologically-Active Dimer Of Fibroblast Growth Factor" . . . . . 100.00 135 100.00 100.00 2.49e-92 . . . . 17464 1 37 no PDB 2ERM . "Solution Structure Of A Biologically Active Human Fgf-1 Monomer, Complexed To A Hexasaccharide Heparin-Analogue" . . . . . 100.00 139 100.00 100.00 4.80e-92 . . . . 17464 1 38 no PDB 2HW9 . "Crystal Structure Of Lys12cysCYS117VAL MUTANT OF HUMAN Acidic Fibroblast Growth Factor At 1.60 Angstrom Resolution" . . . . . 100.00 146 98.48 98.48 3.13e-89 . . . . 17464 1 39 no PDB 2HWA . "Crystal Structure Of Lys12thrCYS117VAL MUTANT OF HUMAN Acidic Fibroblast Growth Factor At 1.65 Angstrom Resolution" . . . . . 100.00 146 98.48 98.48 4.89e-90 . . . . 17464 1 40 no PDB 2HWM . "Crystal Structure Of Lys12valCYS117VAL MUTANT OF HUMAN Acidic Fibroblast Growth Factor At 1.60 Angstrom Resolution" . . . . . 100.00 146 98.48 98.48 8.16e-90 . . . . 17464 1 41 no PDB 2HZ9 . "Crystal Structure Of Lys12valASN95VALCYS117VAL MUTANT OF Human Acidic Fibroblast Growth Factor At 1.70 Angstrom Resolution" . . . . . 100.00 146 97.73 97.73 1.41e-88 . . . . 17464 1 42 no PDB 2J3P . "Crystal Structure Of Rat Fgf1 At 1.4 A" . . . . . 100.00 134 96.97 97.73 8.69e-90 . . . . 17464 1 43 no PDB 2K43 . "Acidic Fibroblast Growth Factor Solution Structure In The Fgf-1-C2a Binary Complex: Key Component In The Fibroblast Growthfacto" . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 44 no PDB 2K4A . "Fgf-1-C2a Binary Complex Structure: A Key Component In The Fibroblast Growthfactor Non-Classical Pathway" . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 45 no PDB 2K8R . "Solution Structure Of Human Acidic Fibroblast Growth Factor In Complex With Anti-Angiogenic Drug Inositol Hexaphosphate (Ip6)" . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 46 no PDB 2KI4 . "Fgf1-S100a13 Complex Structure: Key Component In Non-Classic Way Of Fgf1" . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 47 no PDB 2KI6 . "The Fgf1-S100a13-C2a Hetero-Hexameric Complex Structure: A C In The Non-Classical Pathway For Fgf1 Secretion" . . . . . 100.00 133 100.00 100.00 2.00e-92 . . . . 17464 1 48 no PDB 2NTD . "Human Fibroblast Growth Factor-1 (140 Amino Acid Form) With Cys117valPRO134CYS MUTATIONS" . . . . . 100.00 146 98.48 98.48 6.22e-89 . . . . 17464 1 49 no PDB 2Q9X . "Crystal Structure Of Highly Stable Mutant Q40p/s47i/h93g Of Human Fibroblast Growth Factor-1" . . . . . 100.00 140 97.73 97.73 1.22e-88 . . . . 17464 1 50 no PDB 2RQ9 . "Solution Structure Of Human Acidic Fibroblast Growth Factor (Afgf) In The Presence Of A Protein Stabilizer Ndsb-New" . . . . . 100.00 143 100.00 100.00 2.14e-92 . . . . 17464 1 51 no PDB 2UUS . "Crystal Structure Of The Rat Fgf1-sucrose Octasulfate (sos) Complex" . . . . . 98.48 132 96.92 97.69 3.30e-88 . . . . 17464 1 52 no PDB 3B9U . "Crystal Structure Of L26nD28NH93G MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 97.73 98.48 1.68e-88 . . . . 17464 1 53 no PDB 3BA4 . "Crystal Structure Of L26d Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 1.29e-90 . . . . 17464 1 54 no PDB 3BA5 . "Crystal Structure Of D28a Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 7.72e-91 . . . . 17464 1 55 no PDB 3BA7 . "Crystal Structure Of L26nD28A MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 98.48 98.48 1.08e-89 . . . . 17464 1 56 no PDB 3BAD . "Crystal Structure Of D70aH93G MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 98.48 98.48 2.93e-89 . . . . 17464 1 57 no PDB 3BAG . "Crystal Structure Of K112nN114A MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 98.48 98.48 4.33e-90 . . . . 17464 1 58 no PDB 3BAH . "Crystal Structure Of K112n Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 3.37e-91 . . . . 17464 1 59 no PDB 3BAO . "Crystal Structure Of L26n Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 1.17e-90 . . . . 17464 1 60 no PDB 3BAQ . "Crystal Structure Of L26a Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 4.05e-91 . . . . 17464 1 61 no PDB 3BAU . "Crystal Structure Of K12vL26DD28A MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 97.73 97.73 1.20e-88 . . . . 17464 1 62 no PDB 3BAV . "Crystal Structure Of L26aD28N MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 98.48 99.24 1.83e-90 . . . . 17464 1 63 no PDB 3BB2 . "Crystal Structure Of L26dD28N MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 98.48 99.24 6.35e-90 . . . . 17464 1 64 no PDB 3CQA . "Crystal Structure Of Human Fibroblast Growth Factor-1 With Mutations Glu81ala And Lys101ala" . . . . . 100.00 144 98.48 98.48 1.45e-90 . . . . 17464 1 65 no PDB 3CRG . "Crystal Structure Of Human Fibroblast Growth Factor-1 With Mutations Glu81ala, Glu82asn And Lys101ala" . . . . . 100.00 146 97.73 97.73 1.17e-89 . . . . 17464 1 66 no PDB 3CRH . "Crystal Structure Of Human Fibroblast Growth Factor-1 With Mutations Glu81ser And Lys101ala" . . . . . 100.00 146 98.48 98.48 1.89e-90 . . . . 17464 1 67 no PDB 3CRI . "Crystal Structure Of Human Fibroblast Growth Factor-1 With Mutations Glu81ser, Glu82asn And Lys101ala" . . . . . 100.00 146 97.73 97.73 1.06e-89 . . . . 17464 1 68 no PDB 3CU1 . "Crystal Structure Of 2:2:2 Fgfr2d2:fgf1:sos Complex" . . . . . 97.73 131 100.00 100.00 3.29e-90 . . . . 17464 1 69 no PDB 3FGM . "Crystal Structure Of L44fC83TC117VF132W MUTANT OF HUMAN Acidic Fibroblast Growth Factor" . . . . . 100.00 146 96.97 97.73 2.96e-88 . . . . 17464 1 70 no PDB 3FJ8 . "Crystal Structure Of C117i Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 1.12e-90 . . . . 17464 1 71 no PDB 3FJ9 . "Crystal Structure Of F85w Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 100.00 6.41e-91 . . . . 17464 1 72 no PDB 3FJA . "Crystal Structure Of F132w Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 100.00 6.41e-91 . . . . 17464 1 73 no PDB 3FJB . "Crystal Structure Of V31i Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 100.00 1.77e-91 . . . . 17464 1 74 no PDB 3FJC . "Crystal Structure Of L44w Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 6.62e-91 . . . . 17464 1 75 no PDB 3FJD . "Crystal Structure Of L44fF132W MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 98.48 99.24 2.00e-90 . . . . 17464 1 76 no PDB 3FJE . "Crystal Structure Of C83s Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 8.70e-91 . . . . 17464 1 77 no PDB 3FJF . "Crystal Structure Of C83t Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 9.71e-91 . . . . 17464 1 78 no PDB 3FJH . "Crystal Structure Of C83a Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 6.27e-91 . . . . 17464 1 79 no PDB 3FJI . "Crystal Structure Of K12vC83IC117V MUTANT OF HUMAN ACIDIC Fibroblast Growth Factor" . . . . . 100.00 146 97.73 97.73 9.42e-89 . . . . 17464 1 80 no PDB 3FJJ . "Crystal Structure Of C83v Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 8.06e-91 . . . . 17464 1 81 no PDB 3FJK . "Crystal Structure Of A66c Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 7.00e-91 . . . . 17464 1 82 no PDB 3HAL . "Crystal Structure Of Rabbit Acidic Fibroblast Growth Factor" . . . . . 100.00 146 97.73 98.48 1.85e-89 . . . . 17464 1 83 no PDB 3HOM . "Crystal Structure Of Oxidized A66c Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 7.00e-91 . . . . 17464 1 84 no PDB 3JUT . "Acidic Fibroblast Growth Factor (Fgf-1) Complexed With Gentisic Acid" . . . . . 98.48 130 100.00 100.00 5.08e-91 . . . . 17464 1 85 no PDB 3K1X . "Acidic Fibroblast Growth Factor (Fgf-1) Complexed With Dobes" . . . . . 98.48 130 100.00 100.00 5.08e-91 . . . . 17464 1 86 no PDB 3OJ2 . "Crystal Structure Of Fgf1 Complexed With The Ectodomain Of Fgfr2b Harboring The A172f Pfeiffer Syndrome Mutation" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 87 no PDB 3OJM . "Crystal Structure Of Fgf1 Complexed With The Ectodomain Of Fgfr2b Harboring P253r Apert Mutation" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 88 no PDB 3OJV . "Crystal Structure Of Fgf1 Complexed With The Ectodomain Of Fgfr1c Exhibiting An Ordered Ligand Specificity-Determining Betac'-B" . . . . . 100.00 136 100.00 100.00 1.59e-92 . . . . 17464 1 89 no PDB 3UD7 . "Crystal Structure Analysis Of Fgf1-disaccharide(ni21) Complexes" . . . . . 100.00 141 100.00 100.00 3.91e-92 . . . . 17464 1 90 no PDB 3UD8 . "Crystal Structure Analysis Of Fgf1-disaccharide(ni22) Complex" . . . . . 100.00 141 100.00 100.00 3.91e-92 . . . . 17464 1 91 no PDB 3UD9 . "Crystal Structure Analysis Of Fgf1-disaccharide(ni23) Complex" . . . . . 100.00 141 100.00 100.00 3.91e-92 . . . . 17464 1 92 no PDB 3UDA . "Crystal Structure Analysis Of Fgf1-disaccharide(ni24) Complex" . . . . . 100.00 141 100.00 100.00 3.91e-92 . . . . 17464 1 93 no PDB 4J23 . "Low Resolution Crystal Structure Of The Fgfr2d2d3/fgf1/sr128545 Complex" . . . . . 100.00 138 100.00 100.00 2.91e-92 . . . . 17464 1 94 no PDB 4Q91 . "Crystal Structure Of C16a/k12v/c117v/p134v Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 96.97 96.97 1.17e-87 . . . . 17464 1 95 no PDB 4Q9G . "Crystal Structure Of K12v/c16s/c117v/p134v Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 96.97 96.97 1.63e-87 . . . . 17464 1 96 no PDB 4Q9P . "Crystal Structure Of C16t/k12v/c117v/p134v Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 96.97 96.97 1.61e-87 . . . . 17464 1 97 no PDB 4QAL . "Crystal Structure Of C117a Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 6.27e-91 . . . . 17464 1 98 no PDB 4QBC . "Crystal Structure Of C117t Mutant Of Human Acidic Fibroblast Growth Factor In Sodium Formate Buffer" . . . . . 100.00 146 99.24 99.24 9.71e-91 . . . . 17464 1 99 no PDB 4QBV . "Crystal Structure Of C117t Mutant Of Human Acidic Fibroblast Growth Factor In Sodium Citrate Buffer" . . . . . 100.00 146 99.24 99.24 1.13e-90 . . . . 17464 1 100 no PDB 4QC4 . "Crystal Structure Of C117s Mutant Of Human Acidic Fibroblast Growth Factor" . . . . . 100.00 146 99.24 99.24 8.70e-91 . . . . 17464 1 101 no DBJ BAC29035 . "unnamed protein product [Mus musculus]" . . . . . 100.00 155 96.97 97.73 5.97e-90 . . . . 17464 1 102 no DBJ BAF82451 . "unnamed protein product [Homo sapiens]" . . . . . 100.00 154 99.24 99.24 7.84e-90 . . . . 17464 1 103 no DBJ BAG35227 . "unnamed protein product [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 104 no DBJ BAI46827 . "fibroblast growth factor 1 [synthetic construct]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 105 no EMBL CAA32448 . "unnamed protein product [Rattus norvegicus]" . . . . . 100.00 155 96.97 97.73 5.97e-90 . . . . 17464 1 106 no EMBL CAA36206 . "unnamed protein product [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 107 no EMBL CAA42869 . "acidic fibroblast growth factor [Sus scrofa]" . . . . . 97.73 152 97.67 98.45 6.45e-88 . . . . 17464 1 108 no EMBL CAA46661 . "acidic fibroblast growth factor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 109 no EMBL CAI29610 . "hypothetical protein [Pongo abelii]" . . . . . 100.00 214 100.00 100.00 1.57e-91 . . . . 17464 1 110 no GB AAA37618 . "acidic fibroblast growth factor [Mus musculus]" . . . . . 100.00 155 96.97 97.73 5.97e-90 . . . . 17464 1 111 no GB AAA52446 . "acidic fibroblast growth factor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 112 no GB AAA52638 . "heparin-binding growth factor 1, partial [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 113 no GB AAA79245 . "beta-endothelial cell growth factor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 114 no GB AAB29057 . "acidic fibroblast growth factor, partial [Homo sapiens]" . . . . . 99.24 154 100.00 100.00 1.56e-91 . . . . 17464 1 115 no PRF 1605206A . "acidic fibroblast growth factor" . . . . . 100.00 156 100.00 100.00 1.47e-92 . . . . 17464 1 116 no REF NP_000791 . "fibroblast growth factor 1 isoform 1 precursor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 117 no REF NP_001127073 . "fibroblast growth factor 1 [Pongo abelii]" . . . . . 100.00 214 100.00 100.00 1.57e-91 . . . . 17464 1 118 no REF NP_001138364 . "fibroblast growth factor 1 isoform 1 precursor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 119 no REF NP_001138406 . "fibroblast growth factor 1 isoform 1 precursor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 120 no REF NP_001138407 . "fibroblast growth factor 1 isoform 1 precursor [Homo sapiens]" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 121 no SP P05230 . "RecName: Full=Fibroblast growth factor 1; Short=FGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; AltName: Full" . . . . . 100.00 155 100.00 100.00 1.85e-92 . . . . 17464 1 122 no SP P20002 . "RecName: Full=Fibroblast growth factor 1; Short=FGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; AltName: Full" . . . . . 97.73 152 97.67 98.45 6.45e-88 . . . . 17464 1 123 no SP P34004 . "RecName: Full=Fibroblast growth factor 1; Short=FGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; AltName: Full" . . . . . 100.00 155 97.73 97.73 2.66e-90 . . . . 17464 1 124 no SP P61148 . "RecName: Full=Fibroblast growth factor 1; Short=FGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; AltName: Full" . . . . . 100.00 155 96.97 97.73 5.97e-90 . . . . 17464 1 125 no SP P61149 . "RecName: Full=Fibroblast growth factor 1; Short=FGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; AltName: Full" . . . . . 100.00 155 96.97 97.73 5.97e-90 . . . . 17464 1 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . LYS . 17464 1 2 . LYS . 17464 1 3 . PRO . 17464 1 4 . LYS . 17464 1 5 . LEU . 17464 1 6 . LEU . 17464 1 7 . TYR . 17464 1 8 . CYS . 17464 1 9 . SER . 17464 1 10 . ASN . 17464 1 11 . GLY . 17464 1 12 . GLY . 17464 1 13 . HIS . 17464 1 14 . PHE . 17464 1 15 . LEU . 17464 1 16 . ARG . 17464 1 17 . ILE . 17464 1 18 . LEU . 17464 1 19 . PRO . 17464 1 20 . ASP . 17464 1 21 . GLY . 17464 1 22 . THR . 17464 1 23 . VAL . 17464 1 24 . ASP . 17464 1 25 . GLY . 17464 1 26 . THR . 17464 1 27 . ARG . 17464 1 28 . ASP . 17464 1 29 . ARG . 17464 1 30 . SER . 17464 1 31 . ASP . 17464 1 32 . GLN . 17464 1 33 . HIS . 17464 1 34 . ILE . 17464 1 35 . GLN . 17464 1 36 . LEU . 17464 1 37 . GLN . 17464 1 38 . LEU . 17464 1 39 . SER . 17464 1 40 . ALA . 17464 1 41 . GLU . 17464 1 42 . SER . 17464 1 43 . VAL . 17464 1 44 . GLY . 17464 1 45 . GLU . 17464 1 46 . VAL . 17464 1 47 . TYR . 17464 1 48 . ILE . 17464 1 49 . LYS . 17464 1 50 . SER . 17464 1 51 . THR . 17464 1 52 . GLU . 17464 1 53 . THR . 17464 1 54 . GLY . 17464 1 55 . GLN . 17464 1 56 . TYR . 17464 1 57 . LEU . 17464 1 58 . ALA . 17464 1 59 . MET . 17464 1 60 . ASP . 17464 1 61 . THR . 17464 1 62 . ASP . 17464 1 63 . GLY . 17464 1 64 . LEU . 17464 1 65 . LEU . 17464 1 66 . TYR . 17464 1 67 . GLY . 17464 1 68 . SER . 17464 1 69 . GLN . 17464 1 70 . THR . 17464 1 71 . PRO . 17464 1 72 . ASN . 17464 1 73 . GLU . 17464 1 74 . GLU . 17464 1 75 . CYS . 17464 1 76 . LEU . 17464 1 77 . PHE . 17464 1 78 . LEU . 17464 1 79 . GLU . 17464 1 80 . ARG . 17464 1 81 . LEU . 17464 1 82 . GLU . 17464 1 83 . GLU . 17464 1 84 . ASN . 17464 1 85 . HIS . 17464 1 86 . TYR . 17464 1 87 . ASN . 17464 1 88 . THR . 17464 1 89 . TYR . 17464 1 90 . ILE . 17464 1 91 . SER . 17464 1 92 . LYS . 17464 1 93 . LYS . 17464 1 94 . HIS . 17464 1 95 . ALA . 17464 1 96 . GLU . 17464 1 97 . LYS . 17464 1 98 . ASN . 17464 1 99 . TRP . 17464 1 100 . PHE . 17464 1 101 . VAL . 17464 1 102 . GLY . 17464 1 103 . LEU . 17464 1 104 . LYS . 17464 1 105 . LYS . 17464 1 106 . ASN . 17464 1 107 . GLY . 17464 1 108 . SER . 17464 1 109 . CYS . 17464 1 110 . LYS . 17464 1 111 . ARG . 17464 1 112 . GLY . 17464 1 113 . PRO . 17464 1 114 . ARG . 17464 1 115 . THR . 17464 1 116 . HIS . 17464 1 117 . TYR . 17464 1 118 . GLY . 17464 1 119 . GLN . 17464 1 120 . LYS . 17464 1 121 . ALA . 17464 1 122 . ILE . 17464 1 123 . LEU . 17464 1 124 . PHE . 17464 1 125 . LEU . 17464 1 126 . PRO . 17464 1 127 . LEU . 17464 1 128 . PRO . 17464 1 129 . VAL . 17464 1 130 . SER . 17464 1 131 . SER . 17464 1 132 . ASP . 17464 1 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . LYS 1 1 17464 1 . LYS 2 2 17464 1 . PRO 3 3 17464 1 . LYS 4 4 17464 1 . LEU 5 5 17464 1 . LEU 6 6 17464 1 . TYR 7 7 17464 1 . CYS 8 8 17464 1 . SER 9 9 17464 1 . ASN 10 10 17464 1 . GLY 11 11 17464 1 . GLY 12 12 17464 1 . HIS 13 13 17464 1 . PHE 14 14 17464 1 . LEU 15 15 17464 1 . ARG 16 16 17464 1 . ILE 17 17 17464 1 . LEU 18 18 17464 1 . PRO 19 19 17464 1 . ASP 20 20 17464 1 . GLY 21 21 17464 1 . THR 22 22 17464 1 . VAL 23 23 17464 1 . ASP 24 24 17464 1 . GLY 25 25 17464 1 . THR 26 26 17464 1 . ARG 27 27 17464 1 . ASP 28 28 17464 1 . ARG 29 29 17464 1 . SER 30 30 17464 1 . ASP 31 31 17464 1 . GLN 32 32 17464 1 . HIS 33 33 17464 1 . ILE 34 34 17464 1 . GLN 35 35 17464 1 . LEU 36 36 17464 1 . GLN 37 37 17464 1 . LEU 38 38 17464 1 . SER 39 39 17464 1 . ALA 40 40 17464 1 . GLU 41 41 17464 1 . SER 42 42 17464 1 . VAL 43 43 17464 1 . GLY 44 44 17464 1 . GLU 45 45 17464 1 . VAL 46 46 17464 1 . TYR 47 47 17464 1 . ILE 48 48 17464 1 . LYS 49 49 17464 1 . SER 50 50 17464 1 . THR 51 51 17464 1 . GLU 52 52 17464 1 . THR 53 53 17464 1 . GLY 54 54 17464 1 . GLN 55 55 17464 1 . TYR 56 56 17464 1 . LEU 57 57 17464 1 . ALA 58 58 17464 1 . MET 59 59 17464 1 . ASP 60 60 17464 1 . THR 61 61 17464 1 . ASP 62 62 17464 1 . GLY 63 63 17464 1 . LEU 64 64 17464 1 . LEU 65 65 17464 1 . TYR 66 66 17464 1 . GLY 67 67 17464 1 . SER 68 68 17464 1 . GLN 69 69 17464 1 . THR 70 70 17464 1 . PRO 71 71 17464 1 . ASN 72 72 17464 1 . GLU 73 73 17464 1 . GLU 74 74 17464 1 . CYS 75 75 17464 1 . LEU 76 76 17464 1 . PHE 77 77 17464 1 . LEU 78 78 17464 1 . GLU 79 79 17464 1 . ARG 80 80 17464 1 . LEU 81 81 17464 1 . GLU 82 82 17464 1 . GLU 83 83 17464 1 . ASN 84 84 17464 1 . HIS 85 85 17464 1 . TYR 86 86 17464 1 . ASN 87 87 17464 1 . THR 88 88 17464 1 . TYR 89 89 17464 1 . ILE 90 90 17464 1 . SER 91 91 17464 1 . LYS 92 92 17464 1 . LYS 93 93 17464 1 . HIS 94 94 17464 1 . ALA 95 95 17464 1 . GLU 96 96 17464 1 . LYS 97 97 17464 1 . ASN 98 98 17464 1 . TRP 99 99 17464 1 . PHE 100 100 17464 1 . VAL 101 101 17464 1 . GLY 102 102 17464 1 . LEU 103 103 17464 1 . LYS 104 104 17464 1 . LYS 105 105 17464 1 . ASN 106 106 17464 1 . GLY 107 107 17464 1 . SER 108 108 17464 1 . CYS 109 109 17464 1 . LYS 110 110 17464 1 . ARG 111 111 17464 1 . GLY 112 112 17464 1 . PRO 113 113 17464 1 . ARG 114 114 17464 1 . THR 115 115 17464 1 . HIS 116 116 17464 1 . TYR 117 117 17464 1 . GLY 118 118 17464 1 . GLN 119 119 17464 1 . LYS 120 120 17464 1 . ALA 121 121 17464 1 . ILE 122 122 17464 1 . LEU 123 123 17464 1 . PHE 124 124 17464 1 . LEU 125 125 17464 1 . PRO 126 126 17464 1 . LEU 127 127 17464 1 . PRO 128 128 17464 1 . VAL 129 129 17464 1 . SER 130 130 17464 1 . SER 131 131 17464 1 . ASP 132 132 17464 1 stop_ save_ save_NTS _Entity.Sf_category entity _Entity.Sf_framecode NTS _Entity.Entry_ID 17464 _Entity.ID 2 _Entity.BMRB_code . _Entity.Name NTS _Entity.Type non-polymer _Entity.Polymer_common_type . _Entity.Polymer_type . _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code . _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states no _Entity.Ambiguous_chem_comp_sites no _Entity.Nstd_monomer . _Entity.Nstd_chirality no _Entity.Nstd_linkage no _Entity.Nonpolymer_comp_ID NTS _Entity.Nonpolymer_comp_label $chem_comp_NTS _Entity.Number_of_monomers . _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic no _Entity.Thiol_state 'not present' _Entity.Src_method . _Entity.Parent_entity_ID 2 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight . _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date . loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . NTS . 17464 2 stop_ save_ #################### # Natural source # #################### save_natural_source _Entity_natural_src_list.Sf_category natural_source _Entity_natural_src_list.Sf_framecode natural_source _Entity_natural_src_list.Entry_ID 17464 _Entity_natural_src_list.ID 1 loop_ _Entity_natural_src.ID _Entity_natural_src.Entity_ID _Entity_natural_src.Entity_label _Entity_natural_src.Entity_chimera_segment_ID _Entity_natural_src.NCBI_taxonomy_ID _Entity_natural_src.Type _Entity_natural_src.Common _Entity_natural_src.Organism_name_scientific _Entity_natural_src.Organism_name_common _Entity_natural_src.Organism_acronym _Entity_natural_src.ICTVdb_decimal_code _Entity_natural_src.Superkingdom _Entity_natural_src.Kingdom _Entity_natural_src.Genus _Entity_natural_src.Species _Entity_natural_src.Strain _Entity_natural_src.Variant _Entity_natural_src.Subvariant _Entity_natural_src.Organ _Entity_natural_src.Tissue _Entity_natural_src.Tissue_fraction _Entity_natural_src.Cell_line _Entity_natural_src.Cell_type _Entity_natural_src.ATCC_number _Entity_natural_src.Organelle _Entity_natural_src.Cellular_location _Entity_natural_src.Fragment _Entity_natural_src.Fraction _Entity_natural_src.Secretion _Entity_natural_src.Plasmid _Entity_natural_src.Plasmid_details _Entity_natural_src.Gene_mnemonic _Entity_natural_src.Dev_stage _Entity_natural_src.Details _Entity_natural_src.Citation_ID _Entity_natural_src.Citation_label _Entity_natural_src.Entry_ID _Entity_natural_src.Entity_natural_src_list_ID 1 1 $FGF . 9606 organism . 'Homo sapiens' human . . Eukaryota Metazoa Homo sapiens . . . . . . . . . . . . . . . . . . . . . 17464 1 stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Entity_experimental_src_list.Sf_category experimental_source _Entity_experimental_src_list.Sf_framecode experimental_source _Entity_experimental_src_list.Entry_ID 17464 _Entity_experimental_src_list.ID 1 loop_ _Entity_experimental_src.ID _Entity_experimental_src.Entity_ID _Entity_experimental_src.Entity_label _Entity_experimental_src.Entity_chimera_segment_ID _Entity_experimental_src.Production_method _Entity_experimental_src.Host_org_scientific_name _Entity_experimental_src.Host_org_name_common _Entity_experimental_src.Host_org_details _Entity_experimental_src.Host_org_NCBI_taxonomy_ID _Entity_experimental_src.Host_org_genus _Entity_experimental_src.Host_org_species _Entity_experimental_src.Host_org_strain _Entity_experimental_src.Host_org_variant _Entity_experimental_src.Host_org_subvariant _Entity_experimental_src.Host_org_organ _Entity_experimental_src.Host_org_tissue _Entity_experimental_src.Host_org_tissue_fraction _Entity_experimental_src.Host_org_cell_line _Entity_experimental_src.Host_org_cell_type _Entity_experimental_src.Host_org_cellular_location _Entity_experimental_src.Host_org_organelle _Entity_experimental_src.Host_org_gene _Entity_experimental_src.Host_org_culture_collection _Entity_experimental_src.Host_org_ATCC_number _Entity_experimental_src.Vector_type _Entity_experimental_src.PDBview_host_org_vector_name _Entity_experimental_src.PDBview_plasmid_name _Entity_experimental_src.Vector_name _Entity_experimental_src.Vector_details _Entity_experimental_src.Vendor_name _Entity_experimental_src.Host_org_dev_stage _Entity_experimental_src.Details _Entity_experimental_src.Citation_ID _Entity_experimental_src.Citation_label _Entity_experimental_src.Entry_ID _Entity_experimental_src.Entity_experimental_src_list_ID 1 1 $FGF . 'recombinant technology' 'Escherichia coli' . . . Escherichia coli . . . . . . . . . . . . . . . . pMG47 . . . . . . 17464 1 stop_ save_ ################################# # Polymer residues and ligands # ################################# save_chem_comp_NTS _Chem_comp.Sf_category chem_comp _Chem_comp.Sf_framecode chem_comp_NTS _Chem_comp.Entry_ID 17464 _Chem_comp.ID NTS _Chem_comp.Provenance . _Chem_comp.Name 'NAPHTHALENE TRISULFONATE' _Chem_comp.Type non-polymer _Chem_comp.BMRB_code . _Chem_comp.PDB_code NTS _Chem_comp.Ambiguous_flag no _Chem_comp.Initial_date 1999-07-08 _Chem_comp.Modified_date 2008-10-14 _Chem_comp.Release_status REL _Chem_comp.Replaced_by . _Chem_comp.Replaces . _Chem_comp.One_letter_code . _Chem_comp.Three_letter_code NTS _Chem_comp.Number_atoms_all . _Chem_comp.Number_atoms_nh . _Chem_comp.PubChem_code . _Chem_comp.Subcomponent_list . _Chem_comp.InChI_code . _Chem_comp.Mon_nstd_flag . _Chem_comp.Mon_nstd_class . _Chem_comp.Mon_nstd_details . _Chem_comp.Mon_nstd_parent . _Chem_comp.Mon_nstd_parent_comp_ID . _Chem_comp.Std_deriv_one_letter_code . _Chem_comp.Std_deriv_three_letter_code . _Chem_comp.Std_deriv_BMRB_code . _Chem_comp.Std_deriv_PDB_code . _Chem_comp.Std_deriv_chem_comp_name . _Chem_comp.Synonyms . _Chem_comp.Formal_charge -3 _Chem_comp.Paramagnetic no _Chem_comp.Aromatic yes _Chem_comp.Formula 'C10 H5 O9 S3' _Chem_comp.Formula_weight 365.336 _Chem_comp.Formula_mono_iso_wt_nat . _Chem_comp.Formula_mono_iso_wt_13C . _Chem_comp.Formula_mono_iso_wt_15N . _Chem_comp.Formula_mono_iso_wt_13C_15N . _Chem_comp.Image_file_name . _Chem_comp.Image_file_format . _Chem_comp.Topo_file_name . _Chem_comp.Topo_file_format . _Chem_comp.Struct_file_name . _Chem_comp.Struct_file_format . _Chem_comp.Stereochem_param_file_name . _Chem_comp.Stereochem_param_file_format . _Chem_comp.Model_details . _Chem_comp.Model_erf . _Chem_comp.Model_source . _Chem_comp.Model_coordinates_details . _Chem_comp.Model_coordinates_missing_flag no _Chem_comp.Ideal_coordinates_details . _Chem_comp.Ideal_coordinates_missing_flag no _Chem_comp.Model_coordinates_db_code 1RML _Chem_comp.Processing_site RCSB _Chem_comp.Vendor . _Chem_comp.Vendor_product_code . _Chem_comp.Details ; Information obtained from PDB's Chemical Component Dictionary at http://wwpdb-remediation.rutgers.edu/downloads.html Downloaded on Wed Feb 16 17:27:39 2011 ; _Chem_comp.DB_query_date . _Chem_comp.DB_last_query_revised_last_date . loop_ _Chem_comp_descriptor.Descriptor _Chem_comp_descriptor.Type _Chem_comp_descriptor.Program _Chem_comp_descriptor.Program_version _Chem_comp_descriptor.Entry_ID _Chem_comp_descriptor.Comp_ID c1cc2c(cc1S(=O)(=O)[O-])cc(cc2S(=O)(=O)[O-])S(=O)(=O)[O-] SMILES 'OpenEye OEToolkits' 1.5.0 17464 NTS c1cc2c(cc1S(=O)(=O)[O-])cc(cc2S(=O)(=O)[O-])S(=O)(=O)[O-] SMILES_CANONICAL 'OpenEye OEToolkits' 1.5.0 17464 NTS InChI=1/C10H8O9S3/c11-20(12,13)7-1-2-9-6(3-7)4-8(21(14,15)16)5-10(9)22(17,18)19/h1-5H,(H,11,12,13)(H,14,15,16)(H,17,18,19)/p-3/fC10H5O9S3/q-3 InChI InChI 1.02b 17464 NTS [O-]S(=O)(=O)c1cc2c(cc1)c(cc(c2)S([O-])(=O)=O)S([O-])(=O)=O SMILES ACDLabs 10.04 17464 NTS [O-][S](=O)(=O)c1ccc2c(c1)cc(cc2[S]([O-])(=O)=O)[S]([O-])(=O)=O SMILES CACTVS 3.341 17464 NTS [O-][S](=O)(=O)c1ccc2c(c1)cc(cc2[S]([O-])(=O)=O)[S]([O-])(=O)=O SMILES_CANONICAL CACTVS 3.341 17464 NTS ZPBSAMLXSQCSOX-JWHHDUTECU InChIKey InChI 1.02b 17464 NTS stop_ loop_ _Chem_comp_identifier.Identifier _Chem_comp_identifier.Type _Chem_comp_identifier.Program _Chem_comp_identifier.Program_version _Chem_comp_identifier.Entry_ID _Chem_comp_identifier.Comp_ID naphthalene-1,3,6-trisulfonate 'SYSTEMATIC NAME' ACDLabs 10.04 17464 NTS naphthalene-1,3,6-trisulfonate 'SYSTEMATIC NAME' 'OpenEye OEToolkits' 1.5.0 17464 NTS stop_ loop_ _Chem_comp_atom.Atom_ID _Chem_comp_atom.BMRB_code _Chem_comp_atom.PDB_atom_ID _Chem_comp_atom.Alt_atom_ID _Chem_comp_atom.Auth_atom_ID _Chem_comp_atom.Type_symbol _Chem_comp_atom.Isotope_number _Chem_comp_atom.Chirality _Chem_comp_atom.Stereo_config _Chem_comp_atom.Charge _Chem_comp_atom.Partial_charge _Chem_comp_atom.Oxidation_number _Chem_comp_atom.Unpaired_electron_number _Chem_comp_atom.Align _Chem_comp_atom.Aromatic_flag _Chem_comp_atom.Leaving_atom_flag _Chem_comp_atom.Substruct_code _Chem_comp_atom.Ionizable _Chem_comp_atom.Drawing_2D_coord_x _Chem_comp_atom.Drawing_2D_coord_y _Chem_comp_atom.Model_Cartn_x _Chem_comp_atom.Model_Cartn_x_esd _Chem_comp_atom.Model_Cartn_y _Chem_comp_atom.Model_Cartn_y_esd _Chem_comp_atom.Model_Cartn_z _Chem_comp_atom.Model_Cartn_z_esd _Chem_comp_atom.Model_Cartn_x_ideal _Chem_comp_atom.Model_Cartn_y_ideal _Chem_comp_atom.Model_Cartn_z_ideal _Chem_comp_atom.PDBX_ordinal _Chem_comp_atom.Details _Chem_comp_atom.Entry_ID _Chem_comp_atom.Comp_ID C1 . C1 . . C . . N 0 . . . . yes no . . . . 15.880 . -2.603 . -1.223 . -1.200 1.184 0.000 1 . 17464 NTS C2 . C2 . . C . . N 0 . . . . yes no . . . . 16.444 . -3.861 . -1.008 . -2.213 0.275 0.000 2 . 17464 NTS C3 . C3 . . C . . N 0 . . . . yes no . . . . 15.774 . -5.011 . -1.421 . -1.948 -1.094 0.000 3 . 17464 NTS C4 . C4 . . C . . N 0 . . . . yes no . . . . 14.536 . -4.903 . -2.051 . -0.670 -1.560 0.000 4 . 17464 NTS C5 . C5 . . C . . N 0 . . . . yes no . . . . 12.727 . -3.553 . -2.900 . 1.736 -1.096 -0.005 5 . 17464 NTS C6 . C6 . . C . . N 0 . . . . yes no . . . . 12.147 . -2.306 . -3.123 . 2.748 -0.186 0.000 6 . 17464 NTS C7 . C7 . . C . . N 0 . . . . yes no . . . . 12.810 . -1.151 . -2.713 . 2.484 1.182 0.000 7 . 17464 NTS C8 . C8 . . C . . N 0 . . . . yes no . . . . 14.050 . -1.245 . -2.081 . 1.205 1.649 0.000 8 . 17464 NTS C9 . C9 . . C . . N 0 . . . . yes no . . . . 14.638 . -2.492 . -1.854 . 0.133 0.740 0.000 9 . 17464 NTS C10 . C10 . . C . . N 0 . . . . yes no . . . . 13.968 . -3.647 . -2.268 . 0.402 -0.651 0.000 10 . 17464 NTS O11 . O11 . . O . . N 0 . . . . no no . . . . 15.658 . 0.030 . 0.094 . -1.476 3.346 1.385 11 . 17464 NTS O12 . O12 . . O . . N 0 . . . . no no . . . . 17.627 . -0.350 . -2.053 . -0.552 3.539 -0.840 12 . 17464 NTS O13 . O13 . . O . . N -1 . . . . no no . . . . 18.030 . -1.640 . 0.556 . -2.900 3.050 -0.545 13 . 17464 NTS O31 . O31 . . O . . N 0 . . . . no no . . . . 17.830 . -6.916 . -2.338 . -3.602 -2.503 1.396 14 . 17464 NTS O32 . O32 . . O . . N 0 . . . . no no . . . . 15.254 . -7.917 . -1.337 . -4.386 -1.584 -0.697 15 . 17464 NTS O33 . O33 . . O . . N -1 . . . . no no . . . . 17.196 . -6.718 . 0.526 . -2.818 -3.423 -0.697 16 . 17464 NTS O61 . O61 . . O . . N 0 . . . . no no . . . . 9.311 . -1.589 . -2.760 . 4.808 -0.878 1.396 17 . 17464 NTS O62 . O62 . . O . . N 0 . . . . no no . . . . 10.038 . -3.808 . -4.544 . 5.193 0.267 -0.698 18 . 17464 NTS O63 . O63 . . O . . N -1 . . . . no no . . . . 10.639 . -1.032 . -5.322 . 4.423 -2.024 -0.697 19 . 17464 NTS S1 . S1 . . S . . N 0 . . . . no no . . . . 16.802 . -1.137 . -0.660 . -1.559 2.909 0.000 20 . 17464 NTS S3 . S3 . . S . . N 0 . . . . no no . . . . 16.515 . -6.647 . -1.139 . -3.289 -2.237 0.000 21 . 17464 NTS S6 . S6 . . S . . N 0 . . . . no no . . . . 10.529 . -2.185 . -3.944 . 4.418 -0.747 0.000 22 . 17464 NTS H2 . H2 . . H . . N 0 . . . . no no . . . . 17.417 . -3.951 . -0.513 . -3.236 0.619 -0.001 23 . 17464 NTS H4 . H4 . . H . . N 0 . . . . no no . . . . 14.015 . -5.812 . -2.376 . -0.480 -2.624 0.000 24 . 17464 NTS H5 . H5 . . H . . N 0 . . . . no no . . . . 12.201 . -4.458 . -3.226 . 1.956 -2.153 -0.005 25 . 17464 NTS H7 . H7 . . H . . N 0 . . . . no no . . . . 12.356 . -0.169 . -2.887 . 3.306 1.883 0.000 26 . 17464 NTS H8 . H8 . . H . . N 0 . . . . no no . . . . 14.546 . -0.320 . -1.771 . 1.015 2.712 0.000 27 . 17464 NTS stop_ loop_ _Chem_comp_bond.ID _Chem_comp_bond.Type _Chem_comp_bond.Value_order _Chem_comp_bond.Atom_ID_1 _Chem_comp_bond.Atom_ID_2 _Chem_comp_bond.Aromatic_flag _Chem_comp_bond.Stereo_config _Chem_comp_bond.Ordinal _Chem_comp_bond.Details _Chem_comp_bond.Entry_ID _Chem_comp_bond.Comp_ID 1 . DOUB C1 C2 yes N 1 . 17464 NTS 2 . SING C1 C9 yes N 2 . 17464 NTS 3 . SING C1 S1 no N 3 . 17464 NTS 4 . SING C2 C3 yes N 4 . 17464 NTS 5 . SING C2 H2 no N 5 . 17464 NTS 6 . DOUB C3 C4 yes N 6 . 17464 NTS 7 . SING C3 S3 no N 7 . 17464 NTS 8 . SING C4 C10 yes N 8 . 17464 NTS 9 . SING C4 H4 no N 9 . 17464 NTS 10 . DOUB C5 C6 yes N 10 . 17464 NTS 11 . SING C5 C10 yes N 11 . 17464 NTS 12 . SING C5 H5 no N 12 . 17464 NTS 13 . SING C6 C7 yes N 13 . 17464 NTS 14 . SING C6 S6 no N 14 . 17464 NTS 15 . DOUB C7 C8 yes N 15 . 17464 NTS 16 . SING C7 H7 no N 16 . 17464 NTS 17 . SING C8 C9 yes N 17 . 17464 NTS 18 . SING C8 H8 no N 18 . 17464 NTS 19 . DOUB C9 C10 yes N 19 . 17464 NTS 20 . DOUB O11 S1 no N 20 . 17464 NTS 21 . DOUB O12 S1 no N 21 . 17464 NTS 22 . SING O13 S1 no N 22 . 17464 NTS 23 . DOUB O31 S3 no N 23 . 17464 NTS 24 . DOUB O32 S3 no N 24 . 17464 NTS 25 . SING O33 S3 no N 25 . 17464 NTS 26 . DOUB O61 S6 no N 26 . 17464 NTS 27 . DOUB O62 S6 no N 27 . 17464 NTS 28 . SING O63 S6 no N 28 . 17464 NTS stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Sample.Sf_category sample _Sample.Sf_framecode sample_1 _Sample.Entry_ID 17464 _Sample.ID 1 _Sample.Type solution _Sample.Sub_type . _Sample.Details . _Sample.Aggregate_sample_number . _Sample.Solvent_system '100% D2O' _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 FGF 'natural abundance' . . 1 $FGF . . 22 . . mg/ml . . . . 17464 1 2 'beta mercaptoethanol' 'natural abundance' . . . . . . 1 . . mM . . . . 17464 1 3 'sodium chloride' 'natural abundance' . . . . . . 150 . . mM . . . . 17464 1 4 NTS 'natural abundance' . . 2 $NTS . . 'bound to FGF' . . mM . . . . 17464 1 5 D2O 'natural abundance' . . . . . . 100 . . % . . . . 17464 1 stop_ save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_1 _Sample_condition_list.Entry_ID 17464 _Sample_condition_list.ID 1 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 6.0 . pH 17464 1 pressure 1 . atm 17464 1 temperature 298 . K 17464 1 stop_ save_ ############################ # Computer software used # ############################ save_LSQKAB _Software.Sf_category software _Software.Sf_framecode LSQKAB _Software.Entry_ID 17464 _Software.ID 1 _Software.Name LSQKAB _Software.Version . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID '(Collaborative Computational Project, Number 4, 1994).' . . 17464 1 stop_ loop_ _Task.Task _Task.Entry_ID _Task.Software_ID 'data analysis' 17464 1 stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _NMR_spectrometer.Sf_category NMR_spectrometer _NMR_spectrometer.Sf_framecode spectrometer_1 _NMR_spectrometer.Entry_ID 17464 _NMR_spectrometer.ID 1 _NMR_spectrometer.Details . _NMR_spectrometer.Manufacturer Bruker _NMR_spectrometer.Model AMX _NMR_spectrometer.Serial_number . _NMR_spectrometer.Field_strength 600 save_ save_NMR_spectrometer_list _NMR_spectrometer_list.Sf_category NMR_spectrometer_list _NMR_spectrometer_list.Sf_framecode NMR_spectrometer_list _NMR_spectrometer_list.Entry_ID 17464 _NMR_spectrometer_list.ID 1 loop_ _NMR_spectrometer_view.ID _NMR_spectrometer_view.Name _NMR_spectrometer_view.Manufacturer _NMR_spectrometer_view.Model _NMR_spectrometer_view.Serial_number _NMR_spectrometer_view.Field_strength _NMR_spectrometer_view.Details _NMR_spectrometer_view.Citation_ID _NMR_spectrometer_view.Citation_label _NMR_spectrometer_view.Entry_ID _NMR_spectrometer_view.NMR_spectrometer_list_ID 1 spectrometer_1 Bruker AMX . 600 . . . 17464 1 stop_ save_ ############################# # NMR applied experiments # ############################# save_experiment_list _Experiment_list.Sf_category experiment_list _Experiment_list.Sf_framecode experiment_list _Experiment_list.Entry_ID 17464 _Experiment_list.ID 1 _Experiment_list.Details . loop_ _Experiment.ID _Experiment.Name _Experiment.Raw_data_flag _Experiment.NMR_spec_expt_ID _Experiment.NMR_spec_expt_label _Experiment.MS_expt_ID _Experiment.MS_expt_label _Experiment.SAXS_expt_ID _Experiment.SAXS_expt_label _Experiment.FRET_expt_ID _Experiment.FRET_expt_label _Experiment.EMR_expt_ID _Experiment.EMR_expt_label _Experiment.Sample_ID _Experiment.Sample_label _Experiment.Sample_state _Experiment.Sample_volume _Experiment.Sample_volume_units _Experiment.Sample_condition_list_ID _Experiment.Sample_condition_list_label _Experiment.Sample_spinning_rate _Experiment.Sample_angle _Experiment.NMR_tube_type _Experiment.NMR_spectrometer_ID _Experiment.NMR_spectrometer_label _Experiment.NMR_spectrometer_probe_ID _Experiment.NMR_spectrometer_probe_label _Experiment.NMR_spectral_processing_ID _Experiment.NMR_spectral_processing_label _Experiment.Mass_spectrometer_ID _Experiment.Mass_spectrometer_label _Experiment.Xray_instrument_ID _Experiment.Xray_instrument_label _Experiment.Fluorescence_instrument_ID _Experiment.Fluorescence_instrument_label _Experiment.EMR_instrument_ID _Experiment.EMR_instrument_label _Experiment.Chromatographic_system_ID _Experiment.Chromatographic_system_label _Experiment.Chromatographic_column_ID _Experiment.Chromatographic_column_label _Experiment.Entry_ID _Experiment.Experiment_list_ID 1 '2D 1H-1H TOCSY' no . . . . . . . . . . 1 $sample_1 isotropic . . 1 $sample_conditions_1 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 17464 1 stop_ save_ save_Chemical_rate_list _Chemical_rate_list.Sf_category chemical_rates _Chemical_rate_list.Sf_framecode Chemical_rate_list _Chemical_rate_list.Entry_ID 17464 _Chemical_rate_list.ID 1 _Chemical_rate_list.Sample_condition_list_ID 1 _Chemical_rate_list.Sample_condition_list_label $sample_conditions_1 _Chemical_rate_list.Details . _Chemical_rate_list.Text_data_format . _Chemical_rate_list.Text_data . loop_ _Chemical_rate_experiment.Experiment_ID _Chemical_rate_experiment.Experiment_name _Chemical_rate_experiment.Sample_ID _Chemical_rate_experiment.Sample_label _Chemical_rate_experiment.Sample_state _Chemical_rate_experiment.Entry_ID _Chemical_rate_experiment.Chemical_rate_list_ID 1 '2D 1H-1H TOCSY' 1 $sample_1 solid 17464 1 stop_ loop_ _Chemical_rate.ID _Chemical_rate.Assembly_ID _Chemical_rate.Assembly_atom_ID _Chemical_rate.Entity_assembly_ID _Chemical_rate.Entity_ID _Chemical_rate.Comp_index_ID _Chemical_rate.Seq_ID _Chemical_rate.Comp_ID _Chemical_rate.Atom_ID _Chemical_rate.Atom_type _Chemical_rate.Atom_isotope_number _Chemical_rate.Val_type _Chemical_rate.Val _Chemical_rate.Val_min _Chemical_rate.Val_max _Chemical_rate.Val_err _Chemical_rate.Val_units _Chemical_rate.Resonance_ID _Chemical_rate.Auth_entity_assembly_ID _Chemical_rate.Auth_seq_ID _Chemical_rate.Auth_comp_ID _Chemical_rate.Auth_atom_ID _Chemical_rate.Entry_ID _Chemical_rate.Chemical_rate_list_ID 1 1 . 1 1 . . . . . . kex 10 . . . s-1 . . . . . 17464 1 stop_ save_